LOC120099772

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC120099772 0.31 0.15 0.0e+00 0.28 0.28 0.28 0.28 2.4e-31 3.5e-31 1.8e-31 1.7e-31
2 pVTA gene expression LOC120099772 0.06 0.07 2.3e-03 0.03 0.01 0.02 0.02 2.3e-03 4.0e-02 8.2e-03 9.4e-03
3 Adipose mRNA stability LOC120099772 0.06 0.05 1.4e-06 0.05 0.05 0.05 0.05 7.1e-06 3.1e-06 2.3e-06 4.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.00.10.2-0.30.2
Area under the delay curve0.20.40.9-0.9-0.50.2
BMI with tail1.03.44.72.02.21.2
BMI without tail1.05.16.22.32.51.9
Body weight1.77.29.93.12.91.8
Weight adjusted by age0.10.30.60.40.80.0
Bone surface0.40.71.11.00.80.7
Bone volume0.20.30.60.80.20.6
Breakpoint value in progressive ratio session1.52.84.1-2.0-0.9-1.9
Number of licking bursts1.13.44.42.12.11.2
Context. condit. distance diff. score0.00.10.10.2-0.20.3
Locomotion velocity, session 10.40.50.9-0.5-0.9-0.5
Locomotion distance, session 10.10.10.2-0.1-0.5-0.4
Locomotion velocity, session 21.21.42.31.51.20.8
Locomotion distance, session 20.30.40.70.90.60.3
Locomotion velocity, session 30.30.40.70.60.20.8
Locomotion distance, session 30.70.71.2-1.0-1.10.3
Stereotopy head waving bouts, day 30.50.61.21.10.70.1
Stereotopy head waving duration, day 30.40.50.80.90.7-0.1
Locomotion velocity, session 70.80.91.7-0.8-1.3-0.5
Locomotion distance, session 70.10.10.30.2-0.30.5
Stereotopy head waving bouts, day 70.40.50.60.80.70.6
Stereotopy head waving duration, day 70.50.60.70.80.80.6
Locomotion velocity, session 80.10.10.4-0.1-0.60.1
Locomotion distance, session 80.00.00.00.2-0.2-0.0
Degree of sensitization distance0.50.51.01.00.70.2
Degree of sensitization stereotypy0.80.81.00.80.91.0
Conditioned locomotion0.10.10.2-0.5-0.10.1
Cocaine response after cond. corrected0.20.40.50.60.50.7
Cocaine response after cond. not corrected0.71.11.31.11.00.9
Cocaine response before conditioning1.51.82.61.61.50.8
Saline control response1.31.72.01.41.31.2
Bone: connectivity density0.00.00.00.20.10.1
Bone: cortical apparent density0.20.30.6-0.3-0.60.7
Bone: cortical area1.22.03.11.81.50.8
Bone: cortical porosity0.60.61.7-0.30.3-1.3
Bone: cortical porosity0.30.30.50.10.6-0.7
Bone: cortical thickness0.30.50.91.00.70.1
Bone: cortical thickness0.50.71.21.10.50.7
Bone: cortical tissue density0.20.40.5-0.4-0.70.7
Condit. Reinf. active minus inactive responses0.60.71.11.00.70.6
Condit. Reinf. active-inactive response ratio0.70.71.01.00.90.5
Condit. Reinf. active responses0.40.50.70.80.40.7
Condit. Reinf. inactive responses0.20.30.7-0.3-0.80.3
Incentive salience index mean0.50.61.01.00.70.6
Condit. Reinf. lever presses0.20.30.40.60.30.5
Condit. Reinf. active minus inactive responses0.10.20.30.1-0.40.6
Condit. Reinf. active-inactive response ratio0.10.20.50.2-0.30.7
Condit. Reinf. active responses0.10.20.4-0.3-0.60.2
Condit. Reinf. inactive responses0.30.40.5-0.7-0.5-0.7
Condit. Reinf. lever presses0.20.30.40.40.70.5
Condit. Reinf. lever reinforcers received0.10.10.3-0.4-0.50.1
Conditioned reinforcement - actives0.83.04.72.21.90.9
Conditioned reinforcement - inactives0.72.03.71.91.30.7
Conditioned locomotion1.11.62.41.61.50.2
Patch foraging indifference point 0 sec0.10.20.50.70.30.1
Patch foraging indifference point AUC2.66.26.82.62.42.5
Delay disc. indifference point, 0s delay0.30.40.5-0.6-0.7-0.5
Delay disc. indifference point, 16s delay0.10.10.3-0.5-0.1-0.1
Delay disc. indifference point, 2s delay0.91.01.8-1.3-0.9-0.7
Delay disc. indifference point, 24s delay0.20.30.80.00.90.1
Delay disc. indifference point, 4s delay0.30.30.60.40.30.8
Delay disc. indifference point, 8s delay0.50.81.8-1.4-0.70.1
Indifference point function ln k1.23.84.8-1.8-2.2-1.8
Indifference point function log k1.23.84.8-1.8-2.2-1.8
Patch foraging total patch changes 0 sec0.10.30.60.80.4-0.0
Patch foraging total patch changes 12 sec2.12.83.61.91.51.6
Patch foraging total patch changes 18 sec1.02.43.31.81.51.3
Patch foraging total patch changes 24 sec0.41.52.31.41.50.3
Patch foraging total patch changes 6 sec1.83.14.02.01.61.7
Patch foraging time to switch 0 sec0.72.93.4-1.8-1.5-1.7
Patch foraging water rate 0 sec0.72.84.32.11.61.2
Patch foraging water rate 12 sec0.00.10.20.20.1-0.4
Patch foraging water rate 18 sec0.00.10.20.2-0.1-0.4
Patch foraging water rate 24 sec0.00.00.00.0-0.2-0.2
Patch foraging water rate 6 sec0.71.12.21.01.50.4
Seeking ratio, delayed vs. immediate footshock1.92.74.3-1.8-2.1-0.8
Distance traveled before self-admin0.00.00.00.0-0.00.2
Distance traveled after self-admin0.30.61.1-1.1-0.7-0.4
Extensor digitorum longus weight1.56.09.83.12.41.6
Bone: elastic displacement0.81.11.4-1.0-1.0-1.2
Bone: elastic work0.10.10.20.40.3-0.4
Bone: endosteal estimation0.00.10.20.00.20.5
Bone: endosteal perimeter0.10.20.20.40.50.3
Epididymis fat weight0.10.61.2-0.6-1.1-0.6
Delta time in closed arm before/after self-admin0.70.61.0-0.7-1.0-0.6
Delta time in open arm before/after self-admin0.20.30.50.50.70.3
Diff in mean of infusions in LGA sessions0.91.73.0-1.7-1.2-0.8
Delay discount exponential model param0.20.30.60.80.3-0.3
Extinction: sum of active levers before priming0.10.10.2-0.1-0.1-0.5
Active lever presses in extinction session 60.80.81.50.61.20.7
Bone: final force0.50.91.41.01.20.3
Bone: final moment0.71.11.61.31.30.4
Food consumed during 24 hour testing period3.26.47.4-2.7-2.1-2.7
Glucose0.71.22.2-1.1-1.50.1
Heart weight0.91.42.11.51.40.5
Delay discount hyperbolic model param0.20.20.50.70.3-0.3
Intermittent access intake day 1-15 change0.00.20.40.6-0.20.1
Intermittent access intake escalation0.00.20.70.8-0.00.2
Intermittent access intake escalation 20.20.30.8-0.2-0.9-0.1
Intermitt. access day 1 inactive lever presses0.10.71.20.71.10.7
Intermitt. access day 15 inactive lever presses0.10.40.60.80.80.0
Intermitt. access escalation Index0.10.40.6-0.80.3-0.8
Intermittent access day 1 total infusions1.02.94.52.11.71.1
Intermittent access day 15 total infusions0.40.92.21.50.60.4
Intermittent access terminal intake (last 3 days)0.40.71.81.30.50.4
Intermittent access total infusions1.61.83.41.91.30.7
Intermittent access day 1 locomotion0.40.71.21.10.9-0.2
Intermittent access day 15 total locomotion0.10.30.50.70.3-0.5
Intermittent access total locomotion1.01.22.71.60.90.1
Intermittent access standard deviation0.10.50.8-0.5-0.9-0.5
Left kidney weight2.620.528.45.34.73.4
Right kidney weight2.618.125.05.04.33.2
Cocaine induced anxiety0.10.10.3-0.2-0.50.4
Post-drug Anxiety0.10.10.2-0.3-0.40.1
Baseline Anxiety0.50.81.0-1.0-0.7-1.0
Tail length0.73.64.42.12.01.6
Length with tail0.62.53.82.01.41.2
Length without tail0.20.91.71.30.90.2
Times rat made contact with spout0.30.40.4-0.6-0.6-0.6
Lifetime Intake1.82.34.02.01.50.7
Liver weight, left2.44.15.42.32.31.3
Liver weight, right1.93.43.71.91.91.7
Locomotor activity1.42.23.41.61.80.8
Locomotor testing distance0.81.93.21.61.80.2
Locomotor testing rearing2.17.910.23.23.11.9
Locomotion in novel chamber0.70.91.2-1.1-1.0-0.7
Locomotion in novel chamber post-restriction0.31.01.3-1.1-1.0-0.9
Fecal boli incidents, locomotor time 10.10.30.50.7-0.2-0.7
Change in fecal boli incidents, locomotor task0.50.50.9-1.0-0.80.1
Time >=10cm from walls, locomotor time 10.30.40.90.00.3-1.0
Bouts of movement, locomotor time 11.62.14.0-2.0-1.2-0.9
Total resting periods, locomotor time 12.42.74.5-2.1-1.6-1.1
Rest time, locomotor task time 10.30.40.7-0.3-0.8-0.7
Distance moved, locomotor task time 10.30.91.30.81.20.9
Vertical activity count, locomotor time 10.10.60.90.30.91.0
Time >=10cm from walls, locomotor time 20.00.10.10.2-0.3-0.4
Bouts of movement, locomotor time 21.75.68.2-2.9-1.5-2.5
Total resting periods, locomotor time 21.45.67.8-2.8-1.6-2.5
Rest time, locomotor task time 20.50.91.3-0.6-1.0-1.2
Distance moved, locomotor task time 21.21.62.51.01.21.6
Vertical activity count, locomotor time 20.40.81.90.20.71.4
Light reinforcement 10.20.81.30.61.2-0.9
Light reinforcement 20.51.22.41.11.50.2
Bone: marrow area0.10.10.30.10.30.5
Bone: maximum diameter2.24.46.72.22.61.2
Bone: maximum force0.20.40.60.80.80.3
Bone: maximum moment0.30.60.90.90.90.3
Mean time between licks in bursts0.00.10.1-0.00.3-0.3
Mean num. licks in bursts1.95.16.6-2.5-2.6-1.6
Cd content in liver0.40.50.6-0.5-0.7-0.8
Co content in liver0.80.91.3-1.1-0.8-0.9
Cu content in liver0.50.60.70.80.60.8
Fe content in liver2.63.24.22.11.51.8
K content in liver0.30.30.30.50.50.5
Mg content in liver0.70.81.00.81.00.8
Mn content in liver1.01.12.11.00.51.4
Na content in liver0.10.10.2-0.1-0.40.1
Rb content in liver0.00.00.00.20.20.1
Se content in liver4.95.76.22.52.52.2
Sr content in liver0.10.10.10.30.4-0.1
Zn content in liver1.92.23.91.62.00.4
Bone: minimum diameter0.30.50.80.90.60.7
Time in familiar zone, hab. session 10.30.30.60.40.2-0.8
Time in novel zone, hab. session 11.01.11.90.80.91.4
Total zone transitions, hab. session 10.00.10.10.2-0.3-0.2
Total locomotion distance, hab. session 10.50.60.8-0.7-0.8-0.9
Locomotion velocity, hab. session 11.21.71.8-1.2-1.3-1.4
Time in familiar zone, hab. session 20.20.30.50.70.5-0.1
Time in novel zone, hab. session 20.20.20.5-0.7-0.4-0.1
Total zone transitions, hab. session 20.20.30.60.80.40.0
Total locomotion distance, hab. session 20.60.81.0-0.8-0.9-1.0
Locomotion velocity, hab. session 20.30.40.5-0.6-0.7-0.7
Novel to familiar place preference ratio0.40.50.70.80.50.8
Novelty place preference0.30.40.50.70.40.6
Time in novel zone, NPP test0.30.40.60.80.50.6
Total zone transitions, NPP test0.10.20.20.40.5-0.4
Total locomotion distance, NPP test0.10.10.30.20.2-0.5
Locomotion velocity, NPP test0.10.10.20.20.2-0.5
Intraocular pressure0.20.30.7-0.3-0.8-0.1
Delta distance traveled before/after self-admin0.50.51.1-1.1-0.5-0.5
Delta ambulatory time before/after self-admin0.10.20.3-0.6-0.3-0.2
Parametrial fat weight0.20.41.00.2-0.41.0
Pavlov. Cond. lever latency0.40.50.8-0.9-0.9-0.3
Pavlov. Cond. magazine entry latency0.30.30.70.60.80.2
Pavlov. Cond. change in total contacts0.30.30.4-0.7-0.5-0.6
Pavlov. Cond. index score0.40.51.00.71.00.2
Pavlov. Cond. latency score0.20.20.50.40.7-0.2
Pavlov. Cond. lever contacts0.30.40.60.70.80.1
Pavlov. Cond. magazine entry number0.10.20.3-0.4-0.6-0.2
Pavlov. Cond. intertrial magazine entries0.00.00.10.1-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.61.10.81.10.3
Pavlov. Cond. response bias1.11.41.81.31.30.9
Pavlov. Cond. lever latency0.10.10.2-0.4-0.4-0.2
Pavlov. Cond. magazine entry latency0.00.10.10.00.4-0.2
Pavlov. Cond. change in total contacts0.20.40.6-0.7-0.8-0.4
Pavlov. Cond. index score0.00.00.1-0.10.2-0.3
Pavlov. Cond. latency score0.00.00.1-0.20.1-0.3
Pavlov. Cond. lever contacts0.20.30.40.60.60.4
Pavlov. Cond. magazine entry number0.30.40.70.60.20.8
Pavlov. Cond. intertrial magazine entries0.00.10.10.1-0.40.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.10.4-0.3
Pavlov. Cond. response bias0.00.00.00.20.20.0
Time in closed arm before self-admin0.30.50.80.90.80.3
Time in closed arm after self-admin1.41.62.1-1.4-1.1-1.2
Time in open arm before self-admin0.20.30.6-0.7-0.2-0.4
Time in open arm after self-admin0.10.10.20.10.50.2
Bone: periosteal estimation0.30.81.01.01.00.7
Bone: periosteal perimeter0.40.91.31.11.00.5
Bone: post-yield work0.20.30.5-0.7-0.6-0.3
Progressive ratio test 1 active lever presses1.93.35.42.31.71.2
Progressive ratio test 1 breakpoint1.73.04.92.21.61.2
Progressive ratio test 1 inactive lever presses1.02.74.12.01.80.9
Progressive ratio test 2 active lever presses2.33.25.72.41.90.5
Progressive ratio test 2 breakpoint2.73.56.12.52.00.5
Progressive ratio test 2 inactive lever presses0.51.73.31.81.20.6
Incentive Sensitization - Responses0.71.93.61.91.5-0.0
Incentive Sensitization - Breakpoint0.81.93.51.91.5-0.1
Sum of active levers in priming session hrs 5-60.50.40.9-1.0-0.4-0.5
Progressive ratio0.51.52.1-1.5-0.5-1.5
Food seeking constrained by brief footshock3.24.04.3-1.9-2.0-2.1
Seeking ratio, punishment vs. effort0.10.30.8-0.2-0.9-0.2
Retroperitoneal fat weight0.10.40.90.2-0.50.9
Reaction time number correct0.83.04.52.11.81.0
Reaction time mean minus median0.10.91.3-1.1-1.1-0.4
Reaction time mean minus median AUC0.00.10.2-0.4-0.5-0.0
Reaction time num false alarms3.66.27.82.82.71.8
Reaction time num false alarms AUC2.55.77.42.72.51.8
Reaction time trials correct on left0.83.04.52.11.81.0
Reaction time trials on left0.93.04.62.11.91.0
Reaction time mean0.81.72.9-1.7-1.3-0.6
Reaction time mean AUC0.51.32.2-1.5-1.1-0.6
Median of all reaction times0.81.32.5-1.6-1.1-0.5
Reaction time omissions0.10.20.40.30.60.1
Reaction time false alarm rate0.70.91.10.91.00.9
Reaction time premature initiation rate0.30.50.9-0.7-0.9-0.2
Reaction time premature initiations0.00.00.10.3-0.10.1
Std. dev. reaction times0.30.81.3-1.1-1.0-0.4
Reaction time trials completed0.93.04.62.11.91.0
Reaction time trials AUC1.14.06.02.42.11.2
Run reversals in cocaine runway, females0.40.40.5-0.7-0.6-0.7
Run reversals in cocaine runway, males0.20.20.40.60.20.5
Latency to leave start box in cocaine runway0.20.30.4-0.4-0.6-0.5
Latency to leave start box in cocaine runway, F0.00.00.10.2-0.20.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.4-0.2-0.4
Std. dev. time between licks in bursts0.20.40.70.40.70.9
Total sessions with >9 infusions2.43.04.82.21.81.1
Short access day 1 total inactive lever presses1.32.54.02.01.70.9
Short access day 10 total inactive lever presses0.21.11.3-1.2-0.7-1.1
Short access day 1 total infusions1.02.03.21.81.50.8
Short access day 10 total infusions2.74.56.02.52.41.4
Short access total infusions2.02.84.02.01.81.0
Short access day 1 locomotion2.33.85.42.31.81.7
Short access day 10 total locomotion0.10.31.0-0.10.0-1.0
Short access total locomotion0.40.61.21.10.8-0.0
One hour access (0.3 mA shock)0.10.10.30.60.1-0.3
Compulsive drug intake0.00.00.10.20.30.1
One hour access (shock baseline)0.30.91.81.30.70.6
Social response proportion0.70.91.00.81.00.9
Social responses0.81.11.71.11.30.7
Social time1.21.93.7-1.9-1.2-0.8
Soleus weight0.20.71.00.81.0-0.6
Bone: stiffness0.71.31.41.21.11.1
Tibialis anterior weight3.110.615.64.03.52.0
Time to tail flick, vehicle, before self-admin1.72.14.01.30.82.0
Time to tail flick, vehicle, after self-admin0.20.40.6-0.6-0.8-0.4
Time to tail flick, test, before self-admin1.01.22.7-0.9-1.60.0
Time to tail flick, test, after self-admin0.40.41.00.1-0.4-1.0
Delta time to tail flick, vehicle, before/after SA0.60.61.0-0.5-1.0-0.8
Delta time to tail flick, test, before/after SA0.70.91.61.31.0-0.4
Tibia length0.51.32.51.01.60.6
Ambulatory time before self-admin0.00.00.1-0.3-0.20.0
Ambulatory time after self-admin0.61.01.7-1.3-0.9-0.7
Bone: tissue strength0.40.50.7-0.7-0.5-0.8
Total heroin consumption0.20.20.30.10.60.5
Bone: trabecular number0.00.00.0-0.0-0.20.1
Bone: trabecular spacing0.00.00.00.0-0.0-0.0
Bone: trabecular thickness0.91.31.91.41.00.9
Bone: trabecular tissue density0.10.20.20.40.50.4
Water consumed over 24 hours0.40.91.1-0.8-1.0-0.9
Number of responses in last shaping day1.51.93.31.51.80.4