LOC120098970

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	mRNA stability	LOC120098970	0.09	0.06	5.6e-03	0.11	0.09	0.09	0.08	1.4e-03	3.2e-03	3.9e-03	5.0e-03
2	Liver	gene expression	LOC120098970	0.1	0.05	1.3e-13	0.09	0.11	0.11	0.11	1.6e-10	3.2e-12	6.2e-12	7.2e-12
3	Brain	mRNA stability	LOC120098970	0.07	0.05	2.7e-07	0.06	0.08	0.06	0.08	1.4e-06	8.0e-08	1.6e-06	1.4e-07
4	PL	mRNA stability	LOC120098970	0.06	0.04	4.1e-07	0.06	0.05	0.04	0.05	6.9e-07	2.3e-06	5.9e-05	3.7e-06
5	Liver	mRNA stability	LOC120098970	0.05	0.05	5.2e-04	0.01	0.02	0.02	0.01	5.2e-02	1.4e-03	9.4e-04	1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.6	0.9	0.8	0.9	-0.6	0.8	0.5
Area under the delay curve	0.4	0.4	0.6	-0.6	-0.4	0.7	-0.8	-0.6
BMI with tail	1.9	6.1	8.9	-2.1	-1.9	2.7	-2.4	-3.0
BMI without tail	1.3	2.6	4.1	-1.5	-1.4	1.5	-1.6	-2.0
Body weight	5.4	22.7	29.4	-5.4	-4.3	4.5	-5.3	-4.1
Weight adjusted by age	0.6	0.7	1.5	-0.9	-0.6	0.9	-1.2	-0.1
Bone surface	0.0	0.1	0.3	0.0	0.0	-0.2	-0.1	0.5
Bone volume	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2	-0.1
Breakpoint value in progressive ratio session	0.3	0.3	1.0	0.6	-0.1	-0.2	0.5	1.0
Number of licking bursts	0.8	0.9	1.6	1.0	0.5	-1.1	0.8	1.3
Context. condit. distance diff. score	1.0	1.2	2.7	1.0	0.6	-1.3	0.7	1.6
Locomotion velocity, session 1	1.1	1.1	1.8	1.1	1.4	-1.1	1.0	0.6
Locomotion distance, session 1	3.1	4.0	5.4	2.2	2.3	-2.0	2.2	1.1
Locomotion velocity, session 2	1.0	1.1	2.9	1.2	0.3	-0.9	0.6	1.7
Locomotion distance, session 2	0.8	1.1	1.5	1.0	1.2	-1.1	1.1	0.8
Locomotion velocity, session 3	0.7	0.8	2.9	-0.4	-0.3	0.6	-0.8	-1.7
Locomotion distance, session 3	0.5	0.5	0.9	1.0	0.9	-0.6	0.6	-0.4
Stereotopy head waving bouts, day 3	1.5	1.8	2.9	-1.7	-1.4	0.9	-1.5	-0.8
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.3	0.2
Locomotion velocity, session 7	0.2	0.2	0.6	0.1	0.7	-0.1	0.1	-0.8
Locomotion distance, session 7	0.9	1.1	2.5	0.8	1.6	-1.0	1.0	0.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.8	-0.4	-0.4	0.6	-0.7	-1.3
Stereotopy head waving duration, day 7	1.2	1.4	2.7	-0.8	-1.0	1.1	-1.2	-1.6
Locomotion velocity, session 8	0.4	0.5	1.6	0.2	0.1	-0.9	0.1	1.3
Locomotion distance, session 8	1.2	1.7	2.6	1.1	1.1	-1.6	1.2	1.4
Degree of sensitization distance	0.3	0.3	1.4	-0.4	-0.1	-0.1	0.0	1.2
Degree of sensitization stereotypy	0.2	0.2	0.8	0.5	0.2	0.1	-0.0	-0.9
Conditioned locomotion	2.6	3.0	5.3	-1.9	-2.3	1.6	-1.8	-0.6
Cocaine response after cond. corrected	0.6	0.6	0.8	-0.9	-0.9	0.8	-0.6	-0.7
Cocaine response after cond. not corrected	0.4	0.5	0.9	-0.9	-0.9	0.5	-0.6	-0.3
Cocaine response before conditioning	0.1	0.1	0.4	-0.1	0.0	-0.4	-0.1	0.6
Saline control response	1.0	1.3	2.2	-1.1	-1.1	1.5	-0.9	-1.0
Bone: connectivity density	0.3	0.5	0.7	0.6	0.7	-0.6	0.6	0.8
Bone: cortical apparent density	0.3	0.4	1.2	-0.7	-0.3	0.5	-0.2	-1.1
Bone: cortical area	0.2	0.2	0.8	-0.4	-0.0	0.4	-0.4	-0.9
Bone: cortical porosity	0.2	0.3	0.7	0.1	0.8	-0.2	-0.0	-0.8
Bone: cortical porosity	0.2	0.2	0.6	0.1	0.8	-0.4	0.1	-0.3
Bone: cortical thickness	0.5	0.9	2.7	0.5	1.1	0.2	0.5	-1.6
Bone: cortical thickness	0.2	0.3	0.8	0.0	-0.1	0.7	-0.1	-0.9
Bone: cortical tissue density	0.3	0.4	1.0	-0.8	-0.4	0.6	-0.3	-1.0
Condit. Reinf. active minus inactive responses	1.3	1.5	2.9	1.4	1.1	-0.8	0.9	1.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.0	0.5	0.0	0.0	0.2	1.0
Condit. Reinf. active responses	0.3	0.4	0.9	0.8	0.6	-0.2	0.3	1.0
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	0.5	-0.0	0.1	-0.1
Incentive salience index mean	0.8	1.0	2.2	1.2	0.8	-0.7	0.5	1.5
Condit. Reinf. lever presses	0.3	0.4	1.0	0.8	0.5	-0.5	0.2	1.0
Condit. Reinf. active minus inactive responses	0.8	1.0	2.0	0.7	0.8	-1.0	0.8	1.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.0	0.2	0.3	-0.7	0.4	1.0
Condit. Reinf. active responses	0.9	1.2	2.0	0.9	0.9	-1.1	1.0	1.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.1	-0.1
Condit. Reinf. lever presses	3.8	5.2	5.9	2.2	2.2	-2.3	2.4	2.4
Condit. Reinf. lever reinforcers received	1.7	2.4	3.1	1.5	1.4	-1.5	1.5	1.8
Conditioned reinforcement - actives	0.6	0.6	1.6	-0.8	0.1	0.5	-0.8	-1.3
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.1	0.6	-0.4	0.3	0.3
Conditioned locomotion	0.3	0.4	0.7	-0.9	0.0	0.6	-0.8	-0.4
Patch foraging indifference point 0 sec	0.6	1.0	2.0	-0.9	-0.6	1.0	-0.9	-1.4
Patch foraging indifference point AUC	0.2	0.3	0.8	0.3	0.0	-0.6	0.2	0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	0.2	0.0	0.1	-0.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	-0.5	0.1	0.2	-0.5	-0.9
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	0.4	0.5	-0.5	0.5	0.9
Delay disc. indifference point, 24s delay	2.0	1.9	2.5	-1.5	-0.7	1.3	-1.6	-1.6
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	-0.7	-1.0	0.9	-0.9	-0.2
Delay disc. indifference point, 8s delay	0.8	0.8	1.5	-0.8	-0.9	1.1	-1.2	-0.4
Indifference point function ln k	0.2	0.3	0.4	0.6	0.6	-0.5	0.5	0.0
Indifference point function log k	0.2	0.3	0.4	0.6	0.6	-0.5	0.5	0.0
Patch foraging total patch changes 0 sec	0.6	1.0	2.1	-0.9	-0.5	1.0	-0.8	-1.5
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.3	0.1	-0.0	0.0	-0.1
Patch foraging total patch changes 18 sec	1.0	1.3	1.8	-1.1	-1.0	1.2	-1.0	-1.4
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	0.4	0.6	-0.2	0.4	-0.3
Patch foraging total patch changes 6 sec	0.3	0.4	1.3	-0.5	-0.3	0.6	-0.3	-1.1
Patch foraging time to switch 0 sec	1.3	2.1	3.2	-1.1	-1.5	1.8	-1.3	-1.4
Patch foraging water rate 0 sec	0.2	0.3	0.6	0.1	0.8	-0.7	0.4	0.1
Patch foraging water rate 12 sec	0.2	0.2	0.4	0.2	0.6	-0.5	0.4	-0.6
Patch foraging water rate 18 sec	0.2	0.2	0.4	0.1	0.7	-0.5	0.7	0.3
Patch foraging water rate 24 sec	0.2	0.3	0.6	0.5	0.6	-0.8	0.7	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.3	0.6	-0.6	0.5	-0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.4	-0.7	0.1	-0.0	-0.3
Distance traveled before self-admin	1.0	1.1	2.3	-1.0	-1.5	0.8	-1.0	-0.5
Distance traveled after self-admin	0.5	0.5	1.6	-0.6	-1.3	0.3	-0.6	0.4
Extensor digitorum longus weight	0.4	1.7	5.1	0.9	0.6	-1.4	0.8	2.3
Bone: elastic displacement	0.3	0.4	1.2	0.1	0.9	-0.1	0.1	-1.1
Bone: elastic work	0.1	0.2	0.6	-0.0	0.4	0.2	-0.0	-0.8
Bone: endosteal estimation	2.3	5.0	8.6	-2.4	-2.9	1.9	-2.7	0.1
Bone: endosteal perimeter	1.3	2.8	5.3	-1.9	-2.3	1.2	-1.9	0.2
Epididymis fat weight	3.2	7.4	19.2	-2.0	-1.2	3.0	-1.9	-4.4
Delta time in closed arm before/after self-admin	1.6	1.6	2.0	-1.4	-1.0	1.3	-1.2	-1.4
Delta time in open arm before/after self-admin	0.9	0.8	1.0	1.0	0.9	-0.8	1.0	0.9
Diff in mean of infusions in LGA sessions	0.7	0.7	1.5	0.8	0.6	-0.7	0.8	1.2
Delay discount exponential model param	0.3	0.3	0.6	0.6	0.3	-0.6	0.8	0.6
Extinction: sum of active levers before priming	0.2	0.2	0.2	0.5	0.3	-0.4	0.5	0.3
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	0.3	0.5	-0.1	-0.2
Bone: final force	4.3	6.9	8.4	-2.6	-2.4	2.9	-2.5	-2.7
Bone: final moment	3.2	5.3	6.4	-2.3	-2.0	2.5	-2.2	-2.4
Food consumed during 24 hour testing period	0.7	0.8	1.7	-0.8	-1.3	0.8	-0.7	0.7
Glucose	0.4	0.5	1.2	0.3	0.6	-1.1	0.0	1.0
Heart weight	2.5	3.6	4.5	1.7	2.1	-2.0	1.9	1.6
Delay discount hyperbolic model param	0.1	0.1	0.3	0.3	0.2	-0.4	0.5	0.3
Intermittent access intake day 1-15 change	1.4	1.4	2.5	-1.0	-1.2	1.1	-1.0	-1.6
Intermittent access intake escalation	1.9	1.9	2.4	-1.3	-1.6	1.2	-1.4	-1.4
Intermittent access intake escalation 2	0.1	0.1	0.1	0.0	-0.2	-0.4	-0.1	0.2
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	0.0	-0.2	-0.4	0.3	-0.7
Intermitt. access day 15 inactive lever presses	1.6	1.8	2.2	-1.4	-1.5	1.1	-1.4	-1.2
Intermitt. access escalation Index	0.4	0.4	1.0	1.0	0.2	-0.5	0.6	0.5
Intermittent access day 1 total infusions	0.6	0.7	2.0	0.6	1.4	-0.7	0.6	0.5
Intermittent access day 15 total infusions	0.2	0.3	0.9	-0.3	0.1	0.4	-0.4	-1.0
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.8	-0.3	0.1	0.4	-0.5	-0.9
Intermittent access total infusions	0.1	0.2	0.7	0.1	0.8	-0.2	0.2	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.6	-0.1	0.2	-0.4	-0.1
Intermittent access day 15 total locomotion	4.8	5.2	7.2	-2.7	-2.3	2.2	-2.5	-1.5
Intermittent access total locomotion	1.6	1.9	3.2	-1.8	-1.3	1.3	-1.6	-0.5
Intermittent access standard deviation	1.5	1.6	2.4	-1.4	-1.2	1.2	-1.0	-1.5
Left kidney weight	2.9	8.1	12.0	-3.5	-2.4	2.5	-3.1	-2.5
Right kidney weight	3.3	9.1	13.1	-3.6	-3.1	2.7	-3.3	-2.2
Cocaine induced anxiety	0.1	0.1	0.3	0.1	-0.5	-0.3	0.1	0.2
Post-drug Anxiety	0.3	0.4	1.1	0.5	-0.3	-0.4	0.4	1.0
Baseline Anxiety	0.3	0.3	0.4	0.5	0.6	-0.1	0.6	0.7
Tail length	1.0	2.9	6.4	-2.5	-1.7	0.7	-2.1	-0.7
Length with tail	2.0	7.3	13.9	-3.7	-2.5	1.9	-3.2	-1.5
Length without tail	1.5	3.3	5.8	-2.4	-1.6	1.6	-2.1	-0.7
Times rat made contact with spout	1.8	2.1	2.9	1.6	1.6	-1.2	1.7	1.0
Lifetime Intake	0.1	0.1	0.3	-0.3	0.5	0.2	-0.2	-0.4
Liver weight, left	4.4	7.0	10.0	-2.9	-3.2	2.3	-3.1	-1.0
Liver weight, right	1.8	3.0	5.2	-2.0	-2.3	0.7	-2.2	0.7
Locomotor activity	0.1	0.1	0.4	-0.2	-0.7	0.1	-0.3	0.2
Locomotor testing distance	0.0	0.1	0.2	0.5	-0.3	0.0	0.2	0.1
Locomotor testing rearing	0.9	1.4	2.6	-1.2	-1.6	1.1	-1.2	-0.6
Locomotion in novel chamber	0.8	1.0	1.4	1.2	1.2	-1.0	0.9	0.7
Locomotion in novel chamber post-restriction	2.1	2.5	3.1	-1.5	-1.4	1.7	-1.8	-1.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	-0.1	-0.0	0.1	0.3	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.7	-0.3	0.2	-0.2	0.6
Time >=10cm from walls, locomotor time 1	2.0	2.0	4.0	-1.2	-2.0	1.5	-1.4	-0.7
Bouts of movement, locomotor time 1	0.3	0.3	0.8	0.4	-0.0	-0.6	0.5	0.9
Total resting periods, locomotor time 1	0.2	0.2	0.8	-0.1	-0.3	-0.4	0.2	0.9
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.3	0.0	0.0	-0.0	-0.6
Distance moved, locomotor task time 1	0.2	0.2	0.5	-0.1	-0.7	0.7	-0.6	0.1
Vertical activity count, locomotor time 1	0.9	0.9	2.0	-0.5	-1.4	1.2	-0.9	0.5
Time >=10cm from walls, locomotor time 2	4.4	4.7	6.9	-1.9	-2.2	2.6	-2.1	-1.8
Bouts of movement, locomotor time 2	0.4	0.5	1.2	-0.8	-1.1	0.2	-0.6	0.3
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.3	-0.6	-0.4	-0.1	0.8
Rest time, locomotor task time 2	0.0	0.1	0.1	-0.2	-0.2	-0.4	0.2	-0.0
Distance moved, locomotor task time 2	2.1	2.4	4.1	-1.4	-1.4	2.0	-1.7	-1.2
Vertical activity count, locomotor time 2	1.4	1.6	2.5	-1.3	-1.2	1.6	-1.4	-0.5
Light reinforcement 1	2.0	3.6	5.6	-1.6	-2.4	2.1	-1.8	-1.6
Light reinforcement 2	2.4	3.2	5.2	-1.7	-2.3	1.8	-1.7	-1.2
Bone: marrow area	2.4	5.3	8.9	-2.5	-3.0	2.0	-2.7	0.0
Bone: maximum diameter	0.2	0.3	0.6	-0.8	-0.6	0.0	-0.7	0.4
Bone: maximum force	1.3	2.3	2.8	-1.4	-1.2	1.7	-1.6	-1.7
Bone: maximum moment	0.8	1.4	1.7	-1.1	-0.8	1.3	-1.2	-1.3
Mean time between licks in bursts	1.4	2.0	5.1	0.9	0.4	-1.8	0.8	2.3
Mean num. licks in bursts	0.1	0.1	0.3	0.2	0.6	0.1	0.4	-0.4
Cd content in liver	1.7	1.9	3.2	-1.2	-0.7	1.6	-1.2	-1.8
Co content in liver	2.6	3.0	4.9	-1.2	-1.6	2.2	-1.7	-1.8
Cu content in liver	2.6	3.2	4.9	2.1	2.2	-1.4	2.0	0.7
Fe content in liver	4.6	5.5	8.2	-2.5	-1.7	2.1	-2.5	-2.9
K content in liver	1.7	1.7	2.4	1.4	1.1	-1.5	0.9	1.6
Mg content in liver	5.2	5.3	8.6	2.5	1.8	-2.4	1.7	2.9
Mn content in liver	1.2	1.3	4.9	0.6	0.0	-1.2	0.3	2.2
Na content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.2
Rb content in liver	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.4	0.3
Se content in liver	4.6	5.6	8.7	2.3	1.9	-2.8	1.6	3.0
Sr content in liver	0.1	0.0	0.1	0.2	0.2	0.1	0.2	0.4
Zn content in liver	0.1	0.1	0.3	-0.4	0.0	0.1	-0.6	-0.3
Bone: minimum diameter	0.6	1.2	1.8	-1.3	-1.3	0.8	-1.4	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.3	0.5	0.1	0.1	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.2	-0.5	0.3	-0.4	-0.1
Total zone transitions, hab. session 1	2.4	3.4	5.7	2.4	2.1	-1.7	1.8	0.7
Total locomotion distance, hab. session 1	1.8	2.5	3.9	2.0	1.8	-1.7	1.4	0.8
Locomotion velocity, hab. session 1	1.7	2.4	3.5	1.9	1.8	-1.7	1.4	0.8
Time in familiar zone, hab. session 2	0.8	0.8	1.4	0.4	0.4	-1.1	1.2	1.0
Time in novel zone, hab. session 2	0.9	0.9	1.7	-0.5	-0.4	1.3	-1.2	-0.9
Total zone transitions, hab. session 2	0.3	0.3	0.5	0.6	0.5	-0.7	0.7	-0.2
Total locomotion distance, hab. session 2	1.7	2.2	3.3	1.6	1.5	-1.8	1.6	0.8
Locomotion velocity, hab. session 2	2.1	2.8	4.3	1.7	1.7	-2.1	1.8	1.0
Novel to familiar place preference ratio	0.3	0.3	1.1	-0.2	0.1	0.6	-0.5	-1.0
Novelty place preference	0.3	0.3	0.9	-0.2	0.1	0.5	-0.5	-1.0
Time in novel zone, NPP test	0.3	0.3	0.8	-0.4	-0.0	0.5	-0.5	-0.9
Total zone transitions, NPP test	1.6	2.3	3.0	1.5	1.7	-1.6	1.7	0.7
Total locomotion distance, NPP test	1.1	1.6	2.3	1.3	1.5	-1.3	1.4	0.7
Locomotion velocity, NPP test	1.6	2.3	3.0	1.6	1.7	-1.5	1.7	0.8
Intraocular pressure	0.9	1.3	2.0	-1.1	-1.0	1.1	-1.4	-1.0
Delta distance traveled before/after self-admin	0.3	0.3	0.5	0.3	0.6	-0.5	0.6	0.7
Delta ambulatory time before/after self-admin	0.5	0.5	1.2	0.7	0.5	-0.6	0.7	1.1
Parametrial fat weight	2.2	4.3	5.8	-1.8	-2.4	2.1	-2.0	-1.9
Pavlov. Cond. lever latency	1.4	1.7	2.9	-1.7	-1.5	1.3	-0.8	-1.0
Pavlov. Cond. magazine entry latency	1.6	2.1	3.3	1.5	1.3	-1.6	1.0	1.8
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.5	-0.0	0.2	-0.6	0.1
Pavlov. Cond. index score	1.2	1.5	2.1	1.4	1.4	-1.3	0.7	1.2
Pavlov. Cond. latency score	1.0	1.3	1.8	1.3	1.2	-1.2	0.6	1.1
Pavlov. Cond. lever contacts	1.1	1.3	2.2	1.3	1.5	-1.1	0.8	0.7
Pavlov. Cond. magazine entry number	2.0	2.5	3.0	-1.7	-1.4	1.7	-1.3	-1.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.3	0.2	0.7	-0.1	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.2	1.5	1.4	-1.2	0.6	1.0
Pavlov. Cond. response bias	2.3	2.8	3.3	1.8	1.8	-1.8	1.2	1.7
Pavlov. Cond. lever latency	1.9	2.6	3.5	-1.3	-1.9	1.7	-1.7	-1.3
Pavlov. Cond. magazine entry latency	0.3	0.3	0.9	-0.9	-0.4	0.3	-0.6	0.1
Pavlov. Cond. change in total contacts	1.1	1.5	1.8	1.0	1.3	-1.2	1.3	1.2
Pavlov. Cond. index score	0.4	0.6	0.8	0.4	0.8	-0.8	0.7	0.9
Pavlov. Cond. latency score	0.3	0.3	0.6	0.2	0.6	-0.7	0.6	0.8
Pavlov. Cond. lever contacts	1.1	1.5	2.4	1.1	1.6	-1.2	1.3	0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.6	0.3	-0.2	0.3	-0.1
Pavlov. Cond. intertrial magazine entries	1.2	1.6	4.6	1.1	0.1	-1.1	0.9	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.1	0.6	-0.6	0.5	0.7
Pavlov. Cond. response bias	0.7	0.9	1.7	0.7	1.3	-1.0	0.9	0.8
Time in closed arm before self-admin	0.3	0.3	0.6	0.5	0.6	-0.5	0.4	0.8
Time in closed arm after self-admin	0.2	0.2	0.3	-0.2	0.2	0.3	-0.5	-0.6
Time in open arm before self-admin	0.3	0.3	0.4	0.5	0.6	-0.6	0.6	0.3
Time in open arm after self-admin	1.8	2.0	2.7	1.2	1.2	-1.4	1.6	1.5
Bone: periosteal estimation	1.3	2.7	3.9	-1.8	-2.0	1.5	-2.0	-0.5
Bone: periosteal perimeter	0.5	0.9	1.7	-1.1	-1.3	0.7	-1.0	-0.0
Bone: post-yield work	0.1	0.1	0.3	-0.4	-0.3	0.4	-0.5	0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	-0.1	0.7	-0.1	0.2	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	-0.0	0.7	-0.2	0.2	0.2
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.2	-0.9	-0.8	1.2	-1.0	-1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	0.1	0.2	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.1	0.3	0.1	0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	0.3	0.5	-0.5	0.2	0.7
Incentive Sensitization - Responses	0.7	0.7	1.3	1.1	0.6	-0.8	0.8	0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	0.9	0.3	-0.5	0.6	0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.0	0.6	1.0	-0.6	0.6	0.2
Progressive ratio	4.4	5.1	6.2	-2.3	-2.5	2.3	-2.2	-1.9
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.4	0.4	-0.0	0.3	-0.2
Seeking ratio, punishment vs. effort	2.6	3.1	4.8	1.6	2.2	-1.8	1.9	1.1
Retroperitoneal fat weight	1.4	4.5	6.0	-2.4	-1.8	2.0	-2.1	-2.2
Reaction time number correct	1.2	1.8	2.8	-1.3	-1.2	1.4	-0.9	-1.7
Reaction time mean minus median	0.2	0.3	0.8	-0.4	-0.6	-0.2	-0.4	0.9
Reaction time mean minus median AUC	0.2	0.3	0.9	-0.2	-0.3	-0.2	-0.3	1.0
Reaction time num false alarms	0.3	0.4	1.2	0.3	-0.1	-0.7	0.3	1.1
Reaction time num false alarms AUC	0.8	1.1	2.2	0.8	0.4	-1.3	0.8	1.5
Reaction time trials correct on left	1.2	1.8	2.8	-1.3	-1.2	1.4	-0.9	-1.7
Reaction time trials on left	1.2	1.7	2.5	-1.3	-1.2	1.4	-0.9	-1.6
Reaction time mean	0.2	0.2	0.8	-0.2	-0.5	0.0	-0.2	0.9
Reaction time mean AUC	0.2	0.3	0.7	-0.5	-0.8	0.4	-0.5	0.5
Median of all reaction times	0.1	0.2	0.4	-0.2	-0.6	0.2	-0.2	0.6
Reaction time omissions	0.2	0.2	0.6	-0.3	-0.7	-0.2	-0.1	0.7
Reaction time false alarm rate	2.0	2.8	4.6	1.5	1.2	-2.0	1.3	2.1
Reaction time premature initiation rate	0.2	0.3	0.6	0.8	0.3	-0.3	0.6	0.5
Reaction time premature initiations	0.1	0.2	0.5	-0.1	-0.5	0.7	-0.1	-0.5
Std. dev. reaction times	0.3	0.4	1.7	-0.2	-0.3	-0.5	-0.1	1.3
Reaction time trials completed	1.2	1.7	2.5	-1.3	-1.2	1.4	-0.9	-1.6
Reaction time trials AUC	1.2	1.7	2.6	-1.3	-1.2	1.4	-0.9	-1.6
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.1	0.3	0.5	-0.2	-0.3
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.2	-0.3	-0.0	-0.3	0.1
Latency to leave start box in cocaine runway	0.4	0.5	0.7	0.8	0.8	-0.7	0.8	0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	0.7	0.6	0.8	-0.8	0.8	0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.4	0.2	0.0	0.1	-0.6
Std. dev. time between licks in bursts	0.3	0.3	0.8	0.1	-0.1	-0.9	-0.0	0.9
Total sessions with >9 infusions	0.1	0.1	0.3	0.0	0.5	-0.1	0.1	0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.2	0.6	-0.4	0.0	0.2
Short access day 10 total inactive lever presses	0.2	0.3	1.2	-0.0	-1.1	0.0	-0.2	-0.4
Short access day 1 total infusions	1.5	1.6	2.9	0.9	1.7	-1.3	1.1	1.2
Short access day 10 total infusions	0.0	0.0	0.1	-0.4	0.1	-0.1	0.1	-0.1
Short access total infusions	0.1	0.1	0.4	-0.0	0.6	-0.1	0.0	-0.0
Short access day 1 locomotion	0.1	0.2	0.3	0.4	0.4	-0.5	0.4	0.2
Short access day 10 total locomotion	0.5	0.5	1.2	0.2	0.3	-1.0	0.6	1.1
Short access total locomotion	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.1	0.5
One hour access (0.3 mA shock)	0.6	0.7	1.0	0.7	1.0	-1.0	0.9	0.2
Compulsive drug intake	1.8	1.9	2.6	1.1	1.4	-1.6	1.6	1.0
One hour access (shock baseline)	0.1	0.2	0.4	-0.5	-0.2	0.4	-0.6	-0.2
Social response proportion	0.0	0.0	0.1	-0.2	0.0	-0.3	0.1	0.3
Social responses	0.1	0.1	0.3	0.2	-0.1	-0.5	0.3	0.6
Social time	0.7	0.9	2.7	0.6	-0.3	-1.0	0.4	1.6
Soleus weight	0.3	0.9	2.4	-0.7	-0.8	-0.5	-0.7	1.5
Bone: stiffness	0.9	1.5	2.2	-1.0	-1.2	1.5	-1.3	-1.0
Tibialis anterior weight	0.8	2.7	3.1	1.7	1.4	-1.6	1.8	1.7
Time to tail flick, vehicle, before self-admin	2.0	2.1	4.8	-0.8	-2.2	1.3	-1.5	-0.9
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	0.2	0.1	-0.3	0.3	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.0	-0.2	-0.1	-0.0	-0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	3.1	0.7	1.7	-0.9	1.3	0.5
Delta time to tail flick, test, before/after SA	0.8	0.8	1.3	-0.6	-0.9	1.2	-0.9	-0.7
Tibia length	2.4	6.7	9.1	-3.0	-3.0	2.3	-2.9	-1.3
Ambulatory time before self-admin	0.6	0.6	1.1	-0.9	-1.0	0.5	-0.8	-0.6
Ambulatory time after self-admin	0.2	0.2	0.6	-0.2	-0.6	-0.2	-0.1	0.8
Bone: tissue strength	0.1	0.1	0.4	-0.4	0.1	0.3	0.1	-0.6
Total heroin consumption	0.3	0.4	1.2	0.6	0.1	-0.5	0.4	1.1
Bone: trabecular number	0.7	1.1	1.7	1.1	1.3	-0.9	1.1	0.6
Bone: trabecular spacing	1.7	2.2	2.8	-1.7	-1.7	1.4	-1.5	-1.0
Bone: trabecular thickness	0.3	0.4	0.5	-0.6	-0.3	0.6	-0.7	-0.7
Bone: trabecular tissue density	0.1	0.2	0.4	-0.6	0.0	-0.1	-0.3	-0.5
Water consumed over 24 hours	1.3	1.5	2.4	1.2	0.9	-1.1	1.3	1.6
Number of responses in last shaping day	1.7	1.8	4.3	1.1	2.1	-1.4	1.0	0.7