Hub : Genes

LOC120098586

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC120098586	0.04	0.03	2.4e-03	0.03	0.02	0.01	0.01	3.0e-04	3.0e-03	7.0e-03	7.6e-03
2	BLA	gene expression	LOC120098586	0.08	0.05	4.1e-04	0.02	0.06	0.04	0.04	1.8e-02	4.0e-04	2.1e-03	2.1e-03
3	RMTg	gene expression	LOC120098586	0.2	0.16	6.8e-03	-0.01	-0.01	-0.01	-0.01	9.7e-01	9.3e-01	5.8e-01	9.5e-01
4	Brain	gene expression	LOC120098586	0.07	0.04	4.6e-03	-0	0.02	0.03	-0	9.6e-01	5.6e-03	1.3e-03	3.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.1	1.8	3.7	1.9	-1.4	-0.8	-0.8
Area under the delay curve	0.4	0.4	1.1	-0.3	-0.3	-1.0	0.6
BMI with tail	0.6	2.0	4.1	-1.9	0.3	-0.5	2.0
BMI without tail	0.1	0.1	0.2	-0.4	0.5	0.3	-0.1
Body weight	0.0	0.2	0.4	0.2	-0.1	0.5	-0.6
Weight adjusted by age	0.3	0.4	0.7	-0.9	0.5	-0.0	0.7
Bone surface	1.0	1.8	4.0	2.0	-0.0	0.8	-1.7
Bone volume	1.2	2.0	4.3	2.1	-0.1	0.8	-1.8
Breakpoint value in progressive ratio session	0.5	0.5	1.1	-0.2	-1.1	-0.5	0.9
Number of licking bursts	1.9	2.2	4.3	0.8	-2.0	-2.1	0.2
Context. condit. distance diff. score	0.5	0.6	1.1	-1.1	0.1	-0.5	1.0
Locomotion velocity, session 1	1.0	1.1	2.1	1.4	-0.7	-0.1	-1.3
Locomotion distance, session 1	0.8	1.0	1.9	1.0	-1.4	-1.0	-0.2
Locomotion velocity, session 2	1.2	1.4	2.4	1.1	-1.5	-1.5	-0.2
Locomotion distance, session 2	0.6	0.8	1.7	0.6	-1.3	-1.1	0.2
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	0.5	0.3	-0.4
Locomotion distance, session 3	0.6	0.7	1.5	0.9	-0.4	-0.5	-1.2
Stereotopy head waving bouts, day 3	1.4	1.6	3.7	-0.9	1.9	1.4	0.1
Stereotopy head waving duration, day 3	0.4	0.5	0.8	-0.9	0.9	0.3	0.7
Locomotion velocity, session 7	0.1	0.1	0.3	-0.1	-0.2	-0.6	0.1
Locomotion distance, session 7	0.5	0.6	1.1	0.7	-1.0	-0.8	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.4	0.1	-0.2	-0.6
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.6	-0.1	-0.3	-0.5
Locomotion velocity, session 8	0.3	0.3	0.7	0.7	-0.4	0.2	-0.8
Locomotion distance, session 8	0.7	1.0	2.2	0.1	-1.3	-1.5	0.5
Degree of sensitization distance	0.1	0.1	0.3	-0.1	-0.4	0.0	0.6
Degree of sensitization stereotypy	0.1	0.1	0.2	0.1	0.0	-0.3	-0.4
Conditioned locomotion	0.1	0.1	0.2	0.4	0.1	0.4	-0.3
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.4
Cocaine response after cond. not corrected	0.3	0.3	0.5	-0.4	-0.6	-0.5	0.7
Cocaine response before conditioning	0.3	0.3	0.5	0.6	-0.7	-0.7	0.1
Saline control response	3.3	4.3	8.4	2.2	-2.9	-2.0	-0.5
Bone: connectivity density	1.8	2.8	5.9	2.4	-1.7	-0.9	-1.4
Bone: cortical apparent density	0.7	0.9	2.2	-0.7	-0.4	-1.5	0.8
Bone: cortical area	0.2	0.3	0.9	0.9	-0.4	0.1	-0.5
Bone: cortical porosity	0.8	0.9	1.5	-0.7	1.1	1.2	0.5
Bone: cortical porosity	0.9	1.0	2.2	-0.3	1.2	1.5	-0.1
Bone: cortical thickness	0.3	0.4	1.2	-0.7	0.1	-0.3	1.1
Bone: cortical thickness	5.2	6.0	10.8	-0.2	-2.9	-3.3	2.2
Bone: cortical tissue density	0.6	0.7	2.1	-0.6	-0.4	-1.4	0.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.2	0.4	-0.3	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.4	-0.1	-0.6	0.5
Condit. Reinf. active responses	0.0	0.1	0.1	0.2	0.1	-0.4	-0.1
Condit. Reinf. inactive responses	0.9	1.1	2.3	1.5	-0.5	-0.1	-1.3
Incentive salience index mean	0.3	0.3	0.8	0.7	0.3	0.1	-0.9
Condit. Reinf. lever presses	0.9	1.2	2.4	1.3	0.5	0.8	-1.6
Condit. Reinf. active minus inactive responses	0.5	0.7	0.9	0.7	0.6	1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.5	-0.3	1.0	1.2	-0.4
Condit. Reinf. active responses	0.1	0.2	0.5	0.7	-0.2	0.1	-0.4
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.1	-1.0	-0.9	0.7
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.4	-0.1	-0.4	0.7
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.5	-0.1	0.1	-0.2
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.2	0.5	0.5	0.3
Conditioned reinforcement - inactives	0.3	0.3	0.5	-0.4	0.7	0.7	-0.1
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.1
Patch foraging indifference point 0 sec	0.8	1.3	2.2	0.5	1.0	1.3	-1.5
Patch foraging indifference point AUC	0.9	1.0	1.7	1.3	-1.3	-0.6	-0.6
Delay disc. indifference point, 0s delay	0.5	0.5	1.2	0.9	-0.1	0.3	-1.1
Delay disc. indifference point, 16s delay	1.0	1.0	1.8	-1.0	-0.4	-1.1	1.3
Delay disc. indifference point, 2s delay	0.6	0.7	1.2	-1.1	0.6	-0.3	1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.7	0.3	-0.2	0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.4	-0.2	-0.5	-0.2
Delay disc. indifference point, 8s delay	0.5	0.6	1.6	-0.2	-0.5	-1.3	0.6
Indifference point function ln k	1.1	1.6	3.2	-1.4	1.8	0.9	0.5
Indifference point function log k	1.1	1.6	3.2	-1.4	1.8	0.9	0.5
Patch foraging total patch changes 0 sec	0.7	1.1	1.9	0.1	1.1	1.4	-1.1
Patch foraging total patch changes 12 sec	1.7	2.3	3.2	1.8	-1.5	-0.8	-1.7
Patch foraging total patch changes 18 sec	2.7	3.4	6.4	2.5	-1.8	-0.7	-1.9
Patch foraging total patch changes 24 sec	1.6	1.9	4.0	1.8	-0.7	0.0	-2.0
Patch foraging total patch changes 6 sec	0.4	0.6	0.9	1.0	-0.9	-0.5	-0.6
Patch foraging time to switch 0 sec	0.2	0.3	0.7	0.4	-0.9	-0.7	0.1
Patch foraging water rate 0 sec	0.3	0.5	1.4	0.0	0.8	1.2	-0.2
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.7	0.4	-0.3	0.6
Patch foraging water rate 18 sec	0.5	0.6	1.6	-0.1	1.3	0.7	-0.6
Patch foraging water rate 24 sec	0.2	0.3	0.8	-0.4	0.9	0.3	0.3
Patch foraging water rate 6 sec	1.7	2.5	5.4	2.3	-1.7	-0.8	-1.1
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	3.6	-1.4	-0.3	-1.3	1.9
Distance traveled before self-admin	0.8	0.9	1.4	-0.8	1.1	1.2	0.4
Distance traveled after self-admin	1.0	1.1	1.6	-0.9	1.3	1.2	0.6
Extensor digitorum longus weight	0.0	0.0	0.1	-0.2	-0.0	0.4	-0.2
Bone: elastic displacement	0.6	0.7	1.5	-0.6	1.2	0.9	-0.2
Bone: elastic work	0.7	0.9	1.4	-1.1	1.2	0.8	0.5
Bone: endosteal estimation	0.4	0.9	1.6	1.3	-1.2	-0.5	-0.6
Bone: endosteal perimeter	1.0	2.1	4.2	2.0	-0.5	0.6	-1.9
Epididymis fat weight	0.2	0.4	0.9	0.5	-0.6	0.1	-0.9
Delta time in closed arm before/after self-admin	0.6	0.6	1.2	-1.0	0.5	-0.1	1.1
Delta time in open arm before/after self-admin	2.8	2.7	4.5	2.1	-2.0	-0.8	-1.2
Diff in mean of infusions in LGA sessions	0.4	0.5	0.8	0.6	-0.9	-0.8	0.1
Delay discount exponential model param	0.5	0.5	1.3	0.3	0.3	1.2	-0.6
Extinction: sum of active levers before priming	0.9	0.9	2.0	-1.4	0.4	-0.4	1.2
Active lever presses in extinction session 6	0.8	0.8	1.5	-0.3	1.1	1.2	-0.5
Bone: final force	0.1	0.2	0.3	0.5	-0.2	0.5	-0.3
Bone: final moment	0.1	0.1	0.2	0.5	-0.2	0.4	-0.3
Food consumed during 24 hour testing period	5.9	7.1	12.3	3.1	-3.5	-2.3	-1.1
Glucose	1.2	1.9	4.3	0.1	1.4	2.1	-1.0
Heart weight	1.6	2.2	4.1	-1.2	-0.6	-2.0	1.7
Delay discount hyperbolic model param	0.6	0.6	1.8	0.3	0.5	1.3	-0.6
Intermittent access intake day 1-15 change	1.2	1.2	2.2	1.5	-1.2	-0.7	-0.8
Intermittent access intake escalation	1.4	1.4	2.7	1.6	-1.1	-0.6	-1.0
Intermittent access intake escalation 2	1.4	1.4	2.7	1.6	-0.8	-0.3	-1.4
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.9	0.1	1.3	1.4	-1.3
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	-0.6	0.5	0.7	0.4
Intermitt. access escalation Index	0.4	0.3	0.6	0.6	-0.8	-0.2	-0.6
Intermittent access day 1 total infusions	1.0	1.1	1.6	-1.3	1.1	0.9	0.9
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.0	0.4	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.9	-0.2	0.8	1.0	-0.1
Intermittent access total infusions	0.4	0.4	0.8	-0.5	0.8	0.9	0.3
Intermittent access day 1 locomotion	0.6	0.6	0.8	-0.9	0.9	0.8	0.6
Intermittent access day 15 total locomotion	0.5	0.5	0.8	-0.9	0.4	0.6	0.9
Intermittent access total locomotion	0.9	1.0	1.4	-1.2	0.7	0.9	1.1
Intermittent access standard deviation	0.3	0.3	0.8	0.1	0.9	0.6	-0.4
Left kidney weight	0.7	1.9	2.7	1.4	-1.6	-1.2	-1.2
Right kidney weight	0.6	1.8	2.9	1.0	-1.7	-1.4	-1.1
Cocaine induced anxiety	0.5	0.6	1.0	-0.2	0.9	1.0	-0.6
Post-drug Anxiety	0.5	0.6	1.4	-1.2	0.6	0.1	0.7
Baseline Anxiety	0.6	0.6	0.9	-0.3	-0.9	-0.9	0.9
Tail length	1.5	4.6	10.4	2.6	-0.2	1.1	-3.2
Length with tail	0.8	3.1	7.0	1.9	-0.1	1.3	-2.6
Length without tail	0.0	0.1	0.2	-0.4	-0.0	0.3	0.2
Times rat made contact with spout	0.6	0.7	1.4	-0.0	-0.8	-1.2	0.9
Lifetime Intake	0.5	0.6	1.3	-0.4	0.9	1.1	0.0
Liver weight, left	1.1	1.8	3.7	1.3	-1.9	-1.3	-0.4
Liver weight, right	0.9	1.4	2.7	1.4	-1.6	-0.9	-0.7
Locomotor activity	0.9	1.4	2.9	-0.4	-1.0	-1.2	1.7
Locomotor testing distance	0.9	1.5	2.7	-0.5	-1.1	-1.4	1.6
Locomotor testing rearing	2.8	4.4	7.9	1.4	-2.8	-2.7	0.3
Locomotion in novel chamber	2.3	2.9	5.4	-0.5	-1.7	-2.3	1.7
Locomotion in novel chamber post-restriction	0.3	0.4	1.0	0.2	0.4	0.6	-1.0
Fecal boli incidents, locomotor time 1	1.6	1.7	3.6	1.5	0.2	0.9	-1.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	0.3	-0.4	-1.0	-0.4
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.2	-0.1	-0.7	-1.1	0.8
Bouts of movement, locomotor time 1	0.3	0.3	0.7	-0.3	0.5	0.3	0.8
Total resting periods, locomotor time 1	0.6	0.6	1.0	-0.7	0.9	0.4	1.0
Rest time, locomotor task time 1	0.8	0.8	1.8	-0.8	1.3	0.7	0.6
Distance moved, locomotor task time 1	0.3	0.4	0.7	-0.1	-0.8	-0.7	0.4
Vertical activity count, locomotor time 1	2.4	2.5	4.0	2.0	-2.0	-0.7	-1.4
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.3	-1.1	0.9	0.6	0.9
Bouts of movement, locomotor time 2	0.8	0.9	1.7	-1.1	-0.1	-0.9	1.3
Total resting periods, locomotor time 2	0.6	0.7	1.3	-0.7	-0.3	-0.9	1.2
Rest time, locomotor task time 2	0.3	0.3	0.5	0.6	-0.6	-0.7	0.3
Distance moved, locomotor task time 2	1.1	1.3	2.6	-1.6	0.9	0.7	1.1
Vertical activity count, locomotor time 2	0.5	0.5	1.1	0.9	-1.0	-0.1	-0.6
Light reinforcement 1	8.8	16.0	30.8	5.6	-3.9	-1.4	-4.0
Light reinforcement 2	6.2	8.3	17.4	4.2	-2.2	0.2	-3.3
Bone: marrow area	0.4	0.9	1.5	1.2	-1.2	-0.6	-0.5
Bone: maximum diameter	0.3	0.6	0.9	0.9	0.4	0.8	-0.9
Bone: maximum force	0.2	0.3	0.8	0.4	0.3	0.9	-0.4
Bone: maximum moment	0.2	0.3	0.6	0.4	0.3	0.8	-0.5
Mean time between licks in bursts	0.4	0.6	1.7	0.1	-0.9	-1.3	0.1
Mean num. licks in bursts	0.9	1.0	2.0	-0.8	1.4	1.1	0.5
Cd content in liver	0.2	0.2	0.5	0.4	-0.4	-0.7	-0.1
Co content in liver	1.1	1.2	2.8	-1.2	1.7	0.8	0.3
Cu content in liver	0.1	0.1	0.1	-0.3	-0.1	-0.4	-0.1
Fe content in liver	1.6	2.0	3.7	-0.2	1.9	1.9	-0.6
K content in liver	0.2	0.2	0.4	-0.3	0.5	0.6	-0.2
Mg content in liver	0.8	0.8	1.5	-0.6	1.2	1.1	-0.4
Mn content in liver	0.1	0.2	0.2	0.4	0.0	0.5	-0.5
Na content in liver	0.0	0.0	0.1	-0.1	0.0	0.3	0.2
Rb content in liver	0.1	0.1	0.2	0.2	0.4	0.5	-0.4
Se content in liver	2.6	3.2	5.1	1.1	1.3	2.2	-2.3
Sr content in liver	0.2	0.2	0.2	-0.5	0.5	0.5	-0.3
Zn content in liver	0.4	0.4	0.9	-0.4	-0.6	-1.0	0.6
Bone: minimum diameter	1.0	1.8	4.0	2.0	-1.2	-0.2	-1.3
Time in familiar zone, hab. session 1	1.4	1.3	2.8	0.8	-1.4	-1.7	0.0
Time in novel zone, hab. session 1	1.5	1.5	2.3	-1.5	1.1	0.6	1.4
Total zone transitions, hab. session 1	0.2	0.3	0.7	0.6	-0.9	-0.4	0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.3	-0.6	-0.4	0.4
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.7	-0.7	-0.2	-0.2
Time in familiar zone, hab. session 2	1.5	1.5	2.2	1.5	-1.3	-1.0	-1.1
Time in novel zone, hab. session 2	2.2	2.2	4.1	-2.0	0.8	0.1	2.0
Total zone transitions, hab. session 2	1.1	1.4	2.5	1.4	-1.6	-1.2	-0.3
Total locomotion distance, hab. session 2	0.5	0.6	1.1	1.1	-1.0	-0.5	-0.3
Locomotion velocity, hab. session 2	0.4	0.6	1.2	1.1	-0.9	-0.2	-0.5
Novel to familiar place preference ratio	0.9	1.0	1.7	-0.9	-0.5	-1.0	1.3
Novelty place preference	1.1	1.1	1.9	-0.9	-0.6	-1.1	1.4
Time in novel zone, NPP test	1.3	1.3	2.7	-1.3	-0.2	-0.9	1.7
Total zone transitions, NPP test	0.9	1.3	2.8	1.7	-1.0	-0.1	-1.2
Total locomotion distance, NPP test	0.2	0.3	0.5	0.7	-0.6	-0.4	-0.2
Locomotion velocity, NPP test	0.4	0.6	1.2	1.1	-0.7	-0.1	-0.8
Intraocular pressure	1.7	2.3	5.4	-2.3	1.3	0.2	1.5
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.2	0.1	0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.5	-0.2	0.1	-0.4
Parametrial fat weight	0.3	0.6	1.6	0.7	-0.1	0.6	-1.3
Pavlov. Cond. lever latency	1.5	1.9	3.9	0.2	-1.7	-2.0	0.7
Pavlov. Cond. magazine entry latency	1.1	1.5	2.6	-1.2	1.6	1.1	0.7
Pavlov. Cond. change in total contacts	1.7	1.8	3.3	0.5	1.4	1.8	-1.3
Pavlov. Cond. index score	1.6	2.0	4.0	-0.7	2.0	1.8	-0.2
Pavlov. Cond. latency score	1.1	1.5	2.9	-0.4	1.6	1.7	-0.3
Pavlov. Cond. lever contacts	1.8	2.2	4.6	-0.4	1.9	2.1	-0.5
Pavlov. Cond. magazine entry number	2.5	3.1	6.2	1.4	-2.5	-2.0	-0.3
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.9	0.9	0.7	1.2	-1.7
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.8	-1.1	2.4	2.2	-0.0
Pavlov. Cond. response bias	2.3	2.8	5.7	-1.2	2.4	2.0	0.2
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.1	0.3	0.5	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.1	-0.2	-0.3	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.1	0.2	-0.2	0.5
Pavlov. Cond. index score	0.1	0.1	0.3	-0.0	0.1	-0.2	0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	0.0	0.2	-0.1	0.5
Pavlov. Cond. lever contacts	0.4	0.5	1.0	0.2	-0.7	-1.0	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.0	-0.4	-0.3	-0.3
Pavlov. Cond. intertrial magazine entries	1.7	2.2	3.6	1.9	-1.5	-0.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	0.1	-0.2	0.6
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.6
Time in closed arm before self-admin	0.1	0.1	0.4	0.2	0.4	-0.0	-0.6
Time in closed arm after self-admin	0.1	0.1	0.3	-0.4	0.5	0.0	0.2
Time in open arm before self-admin	0.6	0.7	1.4	-1.2	0.6	0.2	1.0
Time in open arm after self-admin	0.2	0.2	0.3	-0.1	-0.6	-0.4	0.4
Bone: periosteal estimation	0.7	1.4	2.7	1.7	-1.4	-0.6	-0.8
Bone: periosteal perimeter	1.0	1.6	3.2	1.8	-0.7	0.0	-1.7
Bone: post-yield work	0.3	0.5	0.8	0.9	-0.9	-0.5	0.1
Progressive ratio test 1 active lever presses	1.7	1.8	2.1	-1.4	1.5	1.4	1.0
Progressive ratio test 1 breakpoint	1.5	1.5	1.9	-1.3	1.4	1.3	0.9
Progressive ratio test 1 inactive lever presses	2.1	2.3	5.2	-0.4	1.8	2.3	-0.7
Progressive ratio test 2 active lever presses	0.7	0.7	1.0	-1.0	0.9	0.7	0.8
Progressive ratio test 2 breakpoint	0.7	0.7	1.2	-1.1	0.7	0.5	1.0
Progressive ratio test 2 inactive lever presses	1.3	1.5	2.6	-1.6	1.3	0.9	1.1
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.0	-0.0	-0.3	-0.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.8	0.9	-1.7	-1.0	-0.3
Progressive ratio	1.3	1.5	2.6	1.1	-1.6	-1.5	-0.2
Food seeking constrained by brief footshock	1.7	2.0	4.2	2.0	-0.6	0.5	-1.8
Seeking ratio, punishment vs. effort	1.2	1.4	3.2	0.4	1.1	1.8	-1.1
Retroperitoneal fat weight	0.2	0.5	1.0	0.7	-0.7	0.2	-1.0
Reaction time number correct	0.6	0.9	1.3	-1.1	1.1	0.5	1.0
Reaction time mean minus median	0.5	0.7	1.1	-1.1	1.1	0.8	-0.1
Reaction time mean minus median AUC	1.1	1.4	2.3	-1.5	1.5	1.1	0.2
Reaction time num false alarms	0.8	1.0	1.9	-1.1	-0.2	-1.0	1.4
Reaction time num false alarms AUC	0.8	1.0	1.7	-1.2	-0.0	-1.0	1.3
Reaction time trials correct on left	0.6	0.9	1.3	-1.1	1.1	0.5	1.0
Reaction time trials on left	0.7	0.9	1.3	-1.1	1.1	0.4	1.0
Reaction time mean	2.0	2.8	5.7	-2.4	1.6	0.7	1.6
Reaction time mean AUC	2.1	2.8	5.5	-2.4	1.6	0.7	1.6
Median of all reaction times	2.3	3.1	6.0	-2.4	1.6	0.6	1.9
Reaction time omissions	0.6	0.8	2.2	-1.5	0.7	0.4	0.5
Reaction time false alarm rate	0.2	0.3	0.6	-0.5	-0.3	-0.8	0.5
Reaction time premature initiation rate	3.7	5.0	10.8	3.3	-1.9	-0.5	-2.3
Reaction time premature initiations	1.8	2.5	5.8	2.4	-1.3	-0.4	-1.6
Std. dev. reaction times	0.7	1.0	2.0	-1.4	1.1	0.6	0.6
Reaction time trials completed	0.7	0.9	1.3	-1.1	1.1	0.4	1.0
Reaction time trials AUC	0.7	1.0	1.4	-1.2	1.1	0.4	1.1
Run reversals in cocaine runway, females	0.7	0.7	1.3	-1.1	0.6	0.6	0.8
Run reversals in cocaine runway, males	0.5	0.5	1.4	-1.2	0.4	-0.3	0.6
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.2	-0.6	-0.4	0.8
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	-0.8	0.6	0.8	0.5
Latency to leave start box in cocaine runway, M	1.9	1.8	3.8	1.5	-1.9	-1.1	-0.2
Std. dev. time between licks in bursts	1.6	1.9	3.1	1.4	-1.7	-1.5	-0.5
Total sessions with >9 infusions	3.8	4.2	7.8	-1.5	2.8	2.6	0.1
Short access day 1 total inactive lever presses	2.2	2.4	5.7	0.3	1.3	2.4	-1.5
Short access day 10 total inactive lever presses	1.6	1.7	4.0	1.2	0.4	1.1	-2.0
Short access day 1 total infusions	5.9	6.3	11.0	-1.7	3.3	3.3	-0.4
Short access day 10 total infusions	0.4	0.5	1.5	-0.2	0.6	1.2	0.1
Short access total infusions	1.3	1.5	3.7	-0.5	1.4	1.9	-0.3
Short access day 1 locomotion	3.2	3.4	6.3	-1.3	2.5	2.4	-0.2
Short access day 10 total locomotion	0.7	0.7	1.6	-1.0	0.5	0.3	1.2
Short access total locomotion	1.9	2.0	3.4	-1.3	1.8	1.6	0.5
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.2	0.3	0.2	0.4
Compulsive drug intake	0.4	0.4	1.3	0.7	0.2	0.0	-1.1
One hour access (shock baseline)	0.7	0.9	2.1	-1.0	-0.2	-0.6	1.4
Social response proportion	0.1	0.1	0.3	-0.5	-0.2	-0.4	0.2
Social responses	2.2	2.8	6.6	0.3	-2.0	-2.6	0.6
Social time	0.3	0.3	0.5	0.4	-0.5	-0.7	-0.7
Soleus weight	0.1	0.4	0.9	0.0	-0.9	-0.8	0.3
Bone: stiffness	0.2	0.2	0.6	0.5	-0.0	0.8	-0.3
Tibialis anterior weight	0.0	0.2	0.3	-0.3	0.6	0.4	-0.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.7	-0.3	-0.1	-0.6
Time to tail flick, vehicle, after self-admin	2.0	2.2	4.5	1.3	-2.1	-1.5	-0.4
Time to tail flick, test, before self-admin	2.2	2.1	3.8	-1.3	1.5	1.9	0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.4	-0.4	-0.6	-0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	0.7	-0.8	-0.2	-0.6
Delta time to tail flick, test, before/after SA	0.7	0.6	2.1	0.3	-0.6	-1.5	0.0
Tibia length	0.5	1.5	3.2	0.2	1.4	1.8	-0.9
Ambulatory time before self-admin	1.3	1.3	2.0	-1.1	1.2	1.4	0.8
Ambulatory time after self-admin	0.4	0.4	1.1	-0.3	0.6	1.1	0.2
Bone: tissue strength	1.0	1.0	1.9	-0.5	1.4	1.3	-0.3
Total heroin consumption	1.0	1.2	2.4	-0.0	-1.3	-1.5	1.0
Bone: trabecular number	0.9	1.4	3.4	1.8	-0.6	-0.1	-1.3
Bone: trabecular spacing	1.2	1.6	3.5	-1.9	0.7	0.2	1.5
Bone: trabecular thickness	0.2	0.2	0.5	0.7	-0.3	0.0	-0.4
Bone: trabecular tissue density	1.0	1.4	2.9	-1.7	0.6	0.1	1.5
Water consumed over 24 hours	1.7	2.0	3.8	1.2	-1.9	-1.7	0.1
Number of responses in last shaping day	2.5	2.6	5.4	-1.6	2.3	1.6	0.1