LOC120098550

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC120098550	0.46	0.16	0.0e+00	0.23	0.31	0.33	0.33	1.4e-25	2.7e-35	9.3e-38	4.9e-38
2	RMTg	intron excision ratio	chr19_9161911_9166563	0.1	0.08	6.2e-03	0.11	0.05	0.07	0.09	7.9e-04	1.6e-02	6.5e-03	2.8e-03
3	Brain	gene expression	LOC120098550	0.18	0.1	1.9e-13	0.14	0.13	0.14	0.14	5.2e-13	3.2e-12	7.4e-13	4.1e-13
4	NAcc	gene expression	LOC120098550	0.12	0.09	3.9e-09	0.07	0.08	0.08	0.09	2.7e-08	1.0e-09	1.4e-09	1.3e-10
5	PL	gene expression	LOC120098550	0.07	0.05	6.2e-06	0.04	0.04	0.04	0.04	2.7e-05	6.0e-05	2.5e-05	1.6e-05
6	Adipose	gene expression	LOC120098550	0.15	0.09	4.5e-12	0.11	0.1	0.1	0.11	4.3e-12	1.2e-10	3.8e-11	8.7e-12
7	pVTA	gene expression	LOC120098550	0.16	0.09	2.5e-07	0.14	0.1	0.12	0.14	9.2e-07	3.3e-05	8.5e-06	1.7e-06
8	LHb	gene expression	LOC120098550	0.43	0.2	1.8e-06	0.26	0.27	0.24	0.25	9.2e-07	4.2e-07	1.8e-06	1.3e-06
9	RMTg	gene expression	LOC120098550	0.18	0.12	3.8e-05	0.21	0.18	0.23	0.2	2.4e-06	1.2e-05	7.9e-07	4.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.4	0.7	1.3	-0.6	1.0	-1.1	-0.4	-0.8	0.7	0.9	-0.9	0.9
Area under the delay curve	0.2	0.2	0.4	-0.2	0.1	0.5	0.5	0.5	-0.6	-0.6	0.4	-0.1
BMI with tail	0.0	0.1	0.2	0.2	0.1	-0.3	-0.4	-0.3	0.3	0.2	-0.3	0.1
BMI without tail	0.0	0.1	0.3	-0.6	-0.0	-0.2	0.4	0.2	0.1	-0.1	-0.0	-0.2
Body weight	0.1	0.5	1.9	-1.4	-0.5	-0.0	1.2	0.7	0.0	-0.0	0.1	-0.7
Weight adjusted by age	0.8	0.9	1.6	-0.7	1.0	-0.9	-0.3	-1.3	1.3	1.0	-1.0	1.0
Bone surface	0.2	0.4	0.8	-0.9	0.9	-0.6	0.2	-0.4	0.3	0.4	-0.4	0.9
Bone volume	0.3	0.5	1.3	-1.1	0.9	-0.8	0.3	-0.3	0.4	0.5	-0.5	0.8
Breakpoint value in progressive ratio session	6.0	6.6	27.9	5.3	-2.0	2.0	-3.3	0.3	-2.1	-2.0	0.9	-1.8
Number of licking bursts	0.1	0.1	0.3	0.4	-0.4	0.4	-0.2	0.5	-0.4	-0.2	0.3	-0.3
Context. condit. distance diff. score	0.4	0.5	1.0	0.6	-1.0	0.8	0.1	0.6	-0.7	-0.7	0.5	-0.9
Locomotion velocity, session 1	0.3	0.4	0.9	0.7	0.2	-0.5	-0.9	-0.9	0.4	0.4	-0.6	0.3
Locomotion distance, session 1	0.2	0.3	0.6	0.2	-0.4	0.5	0.4	0.4	-0.6	-0.8	0.6	-0.4
Locomotion velocity, session 2	0.3	0.4	1.2	1.1	-0.9	0.2	-0.7	0.1	-0.0	-0.0	0.1	-0.8
Locomotion distance, session 2	0.1	0.1	0.3	0.4	-0.3	0.3	0.1	0.1	-0.4	-0.5	0.4	-0.3
Locomotion velocity, session 3	0.3	0.3	0.8	0.8	0.2	-0.5	-0.9	-0.6	0.5	0.4	-0.4	0.2
Locomotion distance, session 3	0.1	0.1	0.2	0.0	-0.1	0.2	0.2	0.2	-0.4	-0.5	0.2	-0.2
Stereotopy head waving bouts, day 3	0.6	0.7	2.4	1.3	-0.2	-0.6	-1.6	-0.7	0.7	0.8	-0.7	0.0
Stereotopy head waving duration, day 3	0.4	0.4	1.1	0.7	0.2	-0.6	-1.1	-0.6	0.6	0.7	-0.7	0.3
Locomotion velocity, session 7	0.4	0.4	1.6	1.2	-0.7	0.0	-1.1	-0.2	-0.0	-0.0	-0.2	-0.6
Locomotion distance, session 7	0.4	0.5	1.5	0.3	-1.2	0.6	0.1	0.7	-0.5	-0.5	0.3	-1.2
Stereotopy head waving bouts, day 7	1.0	1.1	2.1	0.1	1.0	-1.3	-0.9	-1.0	1.4	1.1	-1.1	0.9
Stereotopy head waving duration, day 7	0.7	0.8	1.7	0.2	0.8	-1.2	-0.8	-0.8	1.3	1.0	-0.8	0.7
Locomotion velocity, session 8	0.8	0.9	1.4	0.4	-1.2	1.1	0.4	1.2	-0.9	-0.8	1.0	-1.1
Locomotion distance, session 8	2.3	3.3	5.0	1.3	-2.2	2.1	0.7	1.7	-1.9	-2.0	1.9	-2.0
Degree of sensitization distance	0.3	0.3	0.9	0.3	-0.9	0.5	-0.0	0.5	-0.4	-0.2	0.3	-0.9
Degree of sensitization stereotypy	1.3	1.5	2.6	-0.8	1.4	-1.6	-0.3	-1.0	1.6	1.2	-1.1	1.2
Conditioned locomotion	2.0	2.4	3.4	-0.8	1.7	-1.8	-0.7	-1.6	1.8	1.8	-1.7	1.5
Cocaine response after cond. corrected	0.9	1.0	2.3	1.5	-1.4	1.0	-0.7	0.0	-0.9	-0.7	0.5	-1.1
Cocaine response after cond. not corrected	1.6	1.8	3.9	2.0	-1.9	1.4	-0.7	0.3	-1.2	-1.1	0.9	-1.5
Cocaine response before conditioning	0.3	0.3	0.5	0.6	-0.7	0.6	-0.1	0.5	-0.5	-0.6	0.7	-0.5
Saline control response	3.0	3.9	6.4	-0.9	1.9	-2.4	-1.4	-2.3	2.1	2.2	-2.5	1.7
Bone: connectivity density	0.1	0.2	0.3	0.0	0.4	-0.5	-0.6	-0.5	0.3	0.5	-0.5	0.5
Bone: cortical apparent density	0.9	1.2	2.0	0.3	1.3	-1.0	-1.1	-1.4	0.9	0.8	-0.9	1.4
Bone: cortical area	0.2	0.3	1.4	-1.2	0.4	0.1	1.0	0.3	-0.4	-0.3	0.2	0.3
Bone: cortical porosity	0.1	0.1	0.3	-0.4	0.0	0.3	0.5	0.3	-0.3	-0.3	0.2	-0.1
Bone: cortical porosity	0.1	0.2	0.5	-0.7	0.1	0.2	0.7	0.4	-0.2	-0.2	0.2	-0.1
Bone: cortical thickness	0.1	0.2	0.6	-0.8	0.7	-0.1	0.5	-0.2	-0.2	-0.1	-0.0	0.7
Bone: cortical thickness	0.7	0.8	2.7	-1.6	0.4	0.4	1.6	0.7	-0.6	-0.6	0.6	0.3
Bone: cortical tissue density	0.8	1.0	1.7	0.3	1.2	-1.0	-1.1	-1.3	0.9	0.8	-0.8	1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.8	0.3	-0.1	0.8	0.3	-0.0	-0.1	0.2	0.2
Condit. Reinf. active-inactive response ratio	1.3	1.4	6.3	-2.5	1.1	-0.3	2.1	0.6	-0.2	-0.1	0.2	0.6
Condit. Reinf. active responses	0.0	0.1	0.2	0.4	0.0	-0.2	-0.3	-0.3	0.2	0.2	-0.1	0.1
Condit. Reinf. inactive responses	1.5	1.8	5.8	2.2	-0.3	-0.6	-2.4	-1.4	1.0	0.9	-0.9	0.1
Incentive salience index mean	0.9	1.1	1.9	-0.4	-0.8	1.0	1.3	1.4	-0.9	-1.0	1.2	-0.9
Condit. Reinf. lever presses	1.5	2.0	3.2	0.3	-1.6	1.5	1.1	1.8	-1.2	-1.3	1.7	-1.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	-0.6	0.7	-0.6	-0.3	-0.6	0.7	0.8	-0.7	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.0	-1.0	0.4	-0.1	0.6	0.0	0.2	0.3	-0.2	0.3
Condit. Reinf. active responses	1.7	2.3	3.2	-1.3	1.7	-1.6	-0.6	-1.4	1.8	1.8	-1.6	1.7
Condit. Reinf. inactive responses	0.9	1.1	1.7	-0.6	1.1	-1.2	-0.6	-0.9	1.3	1.2	-1.0	1.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.7	0.5	-0.4	-0.1	-0.4	0.4	0.4	-0.6	0.4
Condit. Reinf. lever reinforcers received	2.0	2.8	3.7	-1.7	1.9	-1.8	-0.4	-1.4	1.9	1.9	-1.7	1.8
Conditioned reinforcement - actives	0.2	0.2	0.6	-0.5	-0.3	0.2	0.8	0.4	-0.2	-0.2	0.2	-0.4
Conditioned reinforcement - inactives	0.3	0.3	0.7	-0.3	-0.3	0.5	0.8	0.6	-0.4	-0.5	0.7	-0.3
Conditioned locomotion	0.8	1.0	2.0	-0.0	1.0	-1.1	-1.0	-1.2	0.9	0.9	-1.4	0.8
Patch foraging indifference point 0 sec	0.2	0.3	0.9	-0.8	-0.3	0.4	0.9	0.8	-0.2	-0.2	0.4	-0.6
Patch foraging indifference point AUC	3.2	3.7	5.1	1.7	-2.3	2.2	0.4	1.9	-2.1	-2.1	2.1	-2.0
Delay disc. indifference point, 0s delay	0.4	0.5	2.1	-1.5	0.1	0.2	1.2	0.6	-0.3	-0.2	0.3	-0.1
Delay disc. indifference point, 16s delay	0.4	0.5	1.3	-0.6	1.1	-0.6	0.0	-0.7	0.3	0.4	-0.7	0.9
Delay disc. indifference point, 2s delay	1.7	1.9	4.1	-0.5	-1.0	1.5	1.5	2.0	-1.4	-1.5	1.5	-1.2
Delay disc. indifference point, 24s delay	1.5	1.5	3.0	-0.3	1.7	-1.2	-0.8	-1.4	0.9	1.0	-1.3	1.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.4	-0.0	0.4	0.6	0.6	-0.5	-0.5	0.4	-0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.0	-0.0	0.3	0.3	0.2	-0.5	-0.4	0.2	-0.1
Indifference point function ln k	5.5	7.7	13.2	-2.2	3.6	-3.2	-0.6	-2.5	2.8	2.7	-2.9	3.1
Indifference point function log k	5.5	7.7	13.2	-2.2	3.6	-3.2	-0.6	-2.5	2.8	2.7	-2.9	3.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.6	-0.8	0.1	-0.2	0.4	0.2	0.3	0.3	-0.2	-0.1
Patch foraging total patch changes 12 sec	2.3	3.0	5.1	1.1	-2.3	2.0	0.6	1.9	-1.7	-1.6	1.8	-2.1
Patch foraging total patch changes 18 sec	2.7	3.4	5.4	-0.5	-1.2	2.1	2.1	2.3	-2.3	-1.9	2.1	-1.4
Patch foraging total patch changes 24 sec	2.1	2.6	3.6	0.7	-1.7	1.9	0.8	1.8	-1.9	-1.8	1.7	-1.7
Patch foraging total patch changes 6 sec	1.5	2.2	3.6	0.2	-1.5	1.7	1.1	1.9	-1.5	-1.5	1.6	-1.6
Patch foraging time to switch 0 sec	1.0	1.5	2.9	1.7	-1.5	1.4	-0.6	0.7	-1.3	-1.3	1.0	-1.2
Patch foraging water rate 0 sec	0.6	1.0	4.8	-2.2	1.0	-0.5	1.5	0.2	0.4	0.4	-0.2	0.7
Patch foraging water rate 12 sec	1.4	2.2	4.1	-2.0	1.9	-1.6	0.4	-1.1	1.3	1.4	-1.4	1.8
Patch foraging water rate 18 sec	0.7	0.9	2.9	-1.7	1.1	-0.9	0.9	-0.2	0.8	0.9	-0.7	0.9
Patch foraging water rate 24 sec	0.3	0.4	1.2	-1.0	-0.5	0.3	1.1	0.7	-0.0	-0.1	0.3	-0.5
Patch foraging water rate 6 sec	0.9	1.3	5.3	-2.3	1.1	-0.9	1.2	0.2	0.9	0.9	-0.5	0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	-0.8	0.1	-0.4	0.4	0.0	0.4	0.7	-0.2	0.0
Distance traveled before self-admin	0.0	0.0	0.1	0.3	-0.0	0.2	-0.3	-0.0	-0.3	-0.4	-0.1	-0.0
Distance traveled after self-admin	0.7	0.8	1.8	0.9	-1.4	1.0	-0.2	0.7	-0.6	-0.7	0.7	-1.2
Extensor digitorum longus weight	0.1	0.5	1.2	0.1	-1.0	0.6	0.5	0.9	-0.7	-0.5	0.6	-1.1
Bone: elastic displacement	1.0	1.1	2.2	0.2	-0.5	1.4	0.9	1.0	-1.4	-1.4	1.5	-0.3
Bone: elastic work	0.8	1.0	1.7	0.4	-0.9	1.2	0.7	1.0	-1.1	-1.3	1.3	-0.6
Bone: endosteal estimation	0.2	0.5	1.5	-1.2	-0.4	0.3	1.2	0.8	-0.4	-0.4	0.3	-0.6
Bone: endosteal perimeter	0.1	0.2	0.4	-0.5	-0.4	0.3	0.6	0.5	-0.3	-0.4	0.2	-0.5
Epididymis fat weight	0.9	2.0	4.6	-0.5	-2.2	1.2	1.3	1.9	-0.6	-0.7	1.2	-2.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.0	0.2	-0.1	0.0	-0.1	-0.3
Delta time in open arm before/after self-admin	0.4	0.3	0.9	0.2	0.2	-0.6	-0.4	-0.8	1.0	0.8	-0.5	0.3
Diff in mean of infusions in LGA sessions	1.8	1.9	8.3	2.9	-1.0	0.9	-1.8	-0.1	-1.2	-1.3	0.4	-0.9
Delay discount exponential model param	0.2	0.3	0.5	0.3	-0.1	-0.6	-0.6	-0.6	0.7	0.7	-0.5	0.1
Extinction: sum of active levers before priming	1.6	1.6	2.5	1.4	-1.5	1.3	-0.2	1.0	-1.6	-1.5	0.8	-1.5
Active lever presses in extinction session 6	1.4	1.4	6.3	2.5	-0.6	0.9	-1.4	0.0	-1.0	-0.9	0.5	-0.6
Bone: final force	0.4	0.7	1.3	-1.0	0.5	-1.0	-0.3	-0.6	1.0	1.0	-1.1	0.5
Bone: final moment	0.6	1.0	1.8	-1.0	0.7	-1.3	-0.4	-0.8	1.2	1.2	-1.4	0.6
Food consumed during 24 hour testing period	0.3	0.3	0.7	0.5	0.2	-0.6	-0.8	-0.7	0.4	0.6	-0.6	0.3
Glucose	0.8	1.2	1.8	-0.4	-0.7	1.2	1.3	1.3	-1.2	-1.3	1.3	-0.7
Heart weight	1.0	1.4	6.1	-2.5	1.0	-0.7	1.9	0.1	0.5	0.6	-0.2	0.8
Delay discount hyperbolic model param	0.4	0.4	0.6	0.4	0.0	-0.7	-0.8	-0.8	0.8	0.8	-0.6	0.2
Intermittent access intake day 1-15 change	0.5	0.5	1.7	-1.0	-0.4	0.2	1.3	1.0	-0.2	-0.2	0.5	-0.5
Intermittent access intake escalation	0.5	0.5	1.7	-1.2	-0.3	0.1	1.3	1.0	-0.1	-0.1	0.5	-0.4
Intermittent access intake escalation 2	0.9	0.9	2.4	-1.0	-0.5	0.6	1.5	1.3	-0.6	-0.6	0.9	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	0.6	0.2	0.1	-0.6	-0.2	-0.0	-0.1	0.1	0.3
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	0.4	-0.6	0.6	0.2	0.4	-0.7	-0.7	0.6	-0.6
Intermitt. access escalation Index	0.7	0.6	2.7	-1.6	0.6	-0.4	1.3	-0.2	0.0	0.2	-0.1	0.6
Intermittent access day 1 total infusions	0.4	0.5	1.8	1.1	0.3	-0.4	-1.3	-0.8	0.3	0.3	-0.7	0.3
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.1	0.1	0.1	0.1	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.7	0.6	0.2	-0.4	-0.8	-0.3	0.2	0.3	-0.5	0.1
Intermittent access total infusions	0.4	0.5	1.4	0.8	0.4	-0.6	-1.2	-0.7	0.6	0.6	-0.7	0.3
Intermittent access day 1 locomotion	0.8	0.8	2.1	1.2	0.9	-0.5	-1.5	-1.2	0.1	0.2	-0.7	0.8
Intermittent access day 15 total locomotion	0.2	0.2	0.6	0.8	-0.2	0.3	-0.3	0.3	-0.4	-0.6	0.3	-0.3
Intermittent access total locomotion	0.5	0.6	1.7	0.9	0.8	-0.6	-1.3	-0.9	0.4	0.3	-0.7	0.7
Intermittent access standard deviation	0.1	0.1	0.3	-0.4	0.0	0.0	0.6	0.5	-0.1	-0.0	0.2	-0.1
Left kidney weight	1.4	3.9	6.6	-1.2	-1.5	1.9	2.6	2.5	-2.1	-1.9	2.1	-1.6
Right kidney weight	1.0	2.8	6.5	-1.8	-1.4	1.2	2.6	2.2	-1.2	-1.0	1.5	-1.5
Cocaine induced anxiety	0.4	0.5	0.9	0.4	0.9	-0.5	-0.8	-1.0	0.4	0.4	-0.5	0.9
Post-drug Anxiety	0.1	0.1	0.4	0.6	-0.4	0.4	-0.2	0.3	-0.4	-0.2	0.5	-0.3
Baseline Anxiety	0.2	0.2	0.6	-0.1	-0.7	0.2	0.4	0.8	-0.4	-0.2	0.4	-0.7
Tail length	1.0	3.1	4.1	-0.4	-2.0	1.8	1.8	1.9	-1.9	-1.7	1.7	-2.0
Length with tail	0.4	1.3	2.7	-1.4	-1.1	0.7	1.6	1.5	-0.8	-0.6	0.7	-1.3
Length without tail	0.2	0.4	1.0	-0.8	0.3	-0.8	-0.1	-0.3	0.8	1.0	-0.9	0.2
Times rat made contact with spout	0.1	0.1	0.5	-0.3	0.7	0.1	0.3	-0.2	-0.3	0.1	0.1	0.7
Lifetime Intake	0.3	0.4	1.1	0.7	0.4	-0.6	-1.0	-0.6	0.5	0.5	-0.6	0.4
Liver weight, left	0.4	0.6	1.2	0.2	-1.1	0.7	0.6	1.0	-0.3	-0.5	0.9	-1.0
Liver weight, right	0.8	1.3	3.2	0.8	-1.8	1.2	0.4	1.2	-0.7	-1.0	1.2	-1.5
Locomotor activity	0.6	1.0	3.3	-1.3	-0.3	0.7	1.8	1.0	-0.5	-0.7	1.0	-0.4
Locomotor testing distance	0.4	0.7	3.1	-1.7	0.8	-0.4	1.4	0.0	0.4	0.2	0.0	0.6
Locomotor testing rearing	1.1	1.7	6.4	-2.5	1.5	-1.0	1.5	-0.5	1.0	0.9	-0.6	1.1
Locomotion in novel chamber	0.5	0.6	1.1	-0.4	-0.6	0.8	1.1	0.8	-0.7	-0.6	1.0	-0.6
Locomotion in novel chamber post-restriction	2.1	2.5	3.9	1.3	-1.8	1.9	0.5	1.1	-2.0	-1.9	1.7	-1.5
Fecal boli incidents, locomotor time 1	0.4	0.4	1.9	1.4	-0.4	-0.0	-1.2	-0.5	-0.1	0.0	-0.3	-0.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.9	-1.0	-0.3	0.6	1.4	0.8	-0.8	-0.8	0.8	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.9	-0.7	0.6	-0.4	0.1	-0.4	-0.4	0.2	-0.5
Bouts of movement, locomotor time 1	0.9	1.0	1.6	-0.6	1.2	-1.1	-0.3	-1.2	0.9	1.1	-1.2	1.0
Total resting periods, locomotor time 1	1.7	1.9	2.7	-0.8	1.6	-1.6	-0.4	-1.6	1.4	1.5	-1.6	1.4
Rest time, locomotor task time 1	1.8	1.9	3.5	-0.0	1.5	-1.6	-1.2	-1.9	1.1	1.1	-1.8	1.3
Distance moved, locomotor task time 1	2.2	2.4	3.8	0.8	-1.9	1.8	0.7	1.9	-1.3	-1.3	1.9	-1.7
Vertical activity count, locomotor time 1	2.0	2.1	2.9	0.8	-1.6	1.7	0.6	1.7	-1.4	-1.3	1.7	-1.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.4	-0.2	-0.2	-0.7	-0.5	0.3	0.4	-0.5	-0.0
Bouts of movement, locomotor time 2	1.7	1.8	3.0	-0.1	1.3	-1.5	-1.2	-1.5	1.6	1.7	-1.4	1.2
Total resting periods, locomotor time 2	1.3	1.4	2.1	-0.2	1.2	-1.3	-0.8	-1.3	1.4	1.5	-1.2	1.1
Rest time, locomotor task time 2	0.9	1.0	2.4	-0.8	1.5	-1.2	-0.0	-1.1	0.6	0.6	-1.0	1.3
Distance moved, locomotor task time 2	1.8	2.1	3.7	1.0	-1.9	1.7	0.2	1.6	-1.4	-1.3	1.5	-1.7
Vertical activity count, locomotor time 2	0.7	0.7	1.5	0.8	-1.2	1.0	-0.1	0.8	-0.7	-0.7	0.8	-1.1
Light reinforcement 1	0.5	0.9	1.4	0.8	-0.9	1.2	0.1	0.8	-1.2	-1.2	1.0	-0.8
Light reinforcement 2	0.6	0.8	1.6	-0.3	0.5	-1.1	-0.7	-0.9	1.3	1.2	-1.0	0.5
Bone: marrow area	0.2	0.5	1.6	-1.3	-0.4	0.3	1.2	0.8	-0.4	-0.4	0.2	-0.6
Bone: maximum diameter	0.4	0.8	2.3	-1.3	-0.0	0.6	1.5	0.9	-0.8	-0.8	0.7	-0.2
Bone: maximum force	0.2	0.3	1.7	-1.3	0.1	-0.4	0.5	0.1	0.2	0.3	-0.5	-0.0
Bone: maximum moment	0.2	0.4	1.7	-1.3	0.3	-0.6	0.4	-0.1	0.3	0.4	-0.7	0.1
Mean time between licks in bursts	0.9	1.2	4.0	1.2	0.7	-0.8	-2.0	-1.1	0.8	0.9	-0.9	1.0
Mean num. licks in bursts	0.5	0.6	1.3	-0.2	1.0	-0.7	-0.4	-1.1	0.7	0.7	-0.8	0.9
Cd content in liver	0.7	0.8	2.0	-0.1	0.5	-1.2	-0.9	-0.7	1.4	1.1	-1.0	0.5
Co content in liver	0.2	0.2	0.7	-0.1	0.8	-0.3	-0.1	-0.4	0.5	0.2	-0.1	0.8
Cu content in liver	0.2	0.3	1.0	-1.0	0.6	-0.4	0.4	-0.0	0.4	0.5	-0.4	0.5
Fe content in liver	0.2	0.2	0.3	0.2	0.4	-0.4	-0.5	-0.6	0.4	0.4	-0.3	0.5
K content in liver	0.6	0.6	1.7	1.1	-1.3	0.8	-0.4	0.4	-0.5	-0.5	0.6	-1.0
Mg content in liver	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.3	-0.4	0.3	0.3	-0.4	0.2
Mn content in liver	0.5	0.5	2.0	-1.4	0.1	0.1	1.3	0.9	-0.3	-0.1	0.4	-0.1
Na content in liver	0.0	0.0	0.1	-0.2	0.1	0.1	0.0	-0.1	-0.3	-0.1	-0.1	0.1
Rb content in liver	0.5	0.6	1.3	0.6	0.4	-0.7	-1.2	-1.1	0.8	0.7	-0.7	0.6
Se content in liver	1.8	2.2	6.5	-2.0	-0.3	0.9	2.5	1.9	-1.1	-1.2	1.3	-0.6
Sr content in liver	1.1	1.0	1.5	-0.2	-0.6	1.1	1.2	1.2	-1.2	-1.1	1.2	-0.7
Zn content in liver	0.6	0.7	3.7	-1.9	0.6	-0.4	1.2	0.6	0.3	0.2	-0.0	0.3
Bone: minimum diameter	0.1	0.3	0.5	-0.3	0.2	-0.7	-0.4	-0.6	0.6	0.6	-0.7	0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	0.1	0.2	0.3	0.3	-0.1	-0.2	0.3	0.1
Time in novel zone, hab. session 1	0.6	0.5	1.0	-0.0	0.9	-0.8	-0.6	-1.0	0.5	0.7	-0.7	0.9
Total zone transitions, hab. session 1	0.2	0.3	0.7	0.8	0.4	-0.5	-0.8	-0.6	0.6	0.4	-0.2	0.6
Total locomotion distance, hab. session 1	0.2	0.3	0.9	0.9	-0.1	-0.3	-0.9	-0.6	0.6	0.3	-0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.8	0.9	-0.4	0.1	-0.7	-0.3	0.3	0.1	0.0	-0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.4	-0.3	0.7	0.2	0.3	-0.6	-0.6	0.6	-0.2
Time in novel zone, hab. session 2	1.3	1.3	2.0	-1.0	1.4	-1.4	-0.3	-1.0	1.1	1.3	-1.2	1.1
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.3	0.1	0.0	-0.2	-0.0	0.1	-0.1	0.2	0.1
Total locomotion distance, hab. session 2	0.0	0.1	0.2	0.2	-0.1	0.4	0.1	0.2	-0.2	-0.4	0.4	-0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.4	-0.3	0.4	-0.1	0.2	-0.1	-0.4	0.3	-0.2
Novel to familiar place preference ratio	1.5	1.6	6.4	-2.5	1.6	-1.1	1.2	-0.1	0.7	0.8	-0.9	1.0
Novelty place preference	1.7	1.7	5.7	-2.4	1.7	-1.3	1.0	-0.3	0.8	1.0	-1.1	1.1
Time in novel zone, NPP test	2.0	2.1	6.7	-2.6	2.0	-1.4	1.1	-0.4	0.8	1.0	-1.2	1.4
Total zone transitions, NPP test	0.2	0.2	0.7	0.8	-0.8	0.3	-0.2	0.3	0.1	-0.2	0.4	-0.6
Total locomotion distance, NPP test	0.0	0.0	0.1	0.3	-0.2	0.1	-0.2	-0.1	0.3	0.0	0.1	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.3	0.6	-0.6	0.4	-0.2	0.2	0.0	-0.3	0.3	-0.4
Intraocular pressure	0.2	0.2	0.8	-0.8	-0.1	-0.1	0.9	0.5	0.0	-0.2	0.0	-0.6
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.2	-0.1	-0.4	-0.4	-0.6	0.7	0.6	-0.4	0.0
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	0.7	-0.7	0.2	-0.4	-0.3	0.2	0.1	0.0	-0.5
Parametrial fat weight	1.5	3.0	7.2	-1.4	-1.1	1.5	2.7	2.1	-1.6	-1.5	1.9	-1.1
Pavlov. Cond. lever latency	1.4	1.7	2.7	-0.4	1.6	-1.5	-1.0	-1.6	0.9	1.2	-1.5	1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.3	0.3	-0.3	0.1	-0.2	0.4	0.4	-0.1	0.3
Pavlov. Cond. change in total contacts	1.5	1.6	2.9	-0.1	0.7	-1.5	-1.1	-1.3	1.7	1.7	-1.6	0.6
Pavlov. Cond. index score	0.0	0.0	0.1	0.0	-0.3	0.1	0.2	0.2	0.3	0.1	0.2	-0.3
Pavlov. Cond. latency score	0.3	0.3	0.7	0.3	-0.9	0.6	0.3	0.7	-0.1	-0.4	0.7	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.0	0.0	-1.0	0.7	0.6	0.9	-0.3	-0.5	0.7	-1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.2	-0.3	0.4	0.5	0.7	-0.5	-0.5	0.5	-0.4
Pavlov. Cond. intertrial magazine entries	1.7	2.0	3.5	-0.4	-1.3	1.4	1.5	1.9	-1.5	-1.5	1.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	-0.2	-0.0	-0.2	0.1	0.0	0.4	0.3	-0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.0	-0.3	0.4	0.3	-0.3	0.2
Pavlov. Cond. lever latency	0.7	0.9	3.4	1.8	-1.2	0.9	-0.6	0.4	-0.6	-0.6	0.9	-0.9
Pavlov. Cond. magazine entry latency	5.2	6.0	8.6	-0.7	-2.2	2.7	2.5	2.9	-2.7	-2.8	2.5	-2.2
Pavlov. Cond. change in total contacts	0.4	0.5	1.1	-0.6	1.1	-0.7	-0.3	-0.8	0.3	0.4	-0.8	1.0
Pavlov. Cond. index score	0.6	0.7	1.2	-0.9	-0.4	0.8	1.1	0.9	-1.0	-1.1	0.6	-0.5
Pavlov. Cond. latency score	0.8	1.0	1.6	-0.8	-0.6	0.9	1.2	1.1	-1.2	-1.2	0.8	-0.7
Pavlov. Cond. lever contacts	0.4	0.5	2.1	-1.5	0.9	-0.6	0.6	-0.2	0.2	0.2	-0.6	0.7
Pavlov. Cond. magazine entry number	3.1	3.8	6.1	0.9	1.5	-2.0	-2.2	-2.5	2.1	2.2	-2.1	1.5
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.6	0.4	0.8	-1.1	-1.1	-1.3	1.1	1.3	-1.1	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-0.8	-0.5	0.9	1.0	1.0	-1.1	-1.2	0.7	-0.6
Pavlov. Cond. response bias	0.3	0.4	2.2	-1.5	0.5	-0.0	1.0	0.4	-0.2	-0.2	-0.0	0.3
Time in closed arm before self-admin	2.4	2.7	3.8	0.9	-1.7	1.9	0.9	1.8	-1.7	-1.8	1.9	-1.7
Time in closed arm after self-admin	2.9	2.9	4.5	0.3	-1.4	2.0	1.3	2.0	-2.1	-2.1	1.9	-1.5
Time in open arm before self-admin	1.1	1.2	2.2	0.2	1.0	-1.1	-1.2	-1.5	1.0	1.2	-1.3	1.1
Time in open arm after self-admin	1.3	1.4	3.0	-0.8	0.9	-1.4	-0.1	-1.0	1.7	1.7	-1.0	0.9
Bone: periosteal estimation	0.3	0.6	2.6	-1.6	0.1	0.1	1.4	0.6	-0.4	-0.4	0.2	-0.1
Bone: periosteal perimeter	0.3	0.5	0.9	-0.6	-0.5	0.7	1.0	0.8	-0.8	-0.8	0.7	-0.5
Bone: post-yield work	0.5	0.6	1.0	-0.5	-0.6	0.8	1.0	1.0	-1.0	-0.9	0.8	-0.6
Progressive ratio test 1 active lever presses	0.6	0.6	2.9	1.7	-0.3	0.2	-1.5	-0.3	-0.3	-0.2	-0.1	-0.2
Progressive ratio test 1 breakpoint	0.7	0.7	3.3	1.8	-0.4	0.4	-1.5	-0.2	-0.4	-0.3	0.0	-0.3
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.8	0.3	0.9	-0.5	-0.8	-0.7	0.3	0.4	-0.3	0.9
Progressive ratio test 2 active lever presses	0.8	0.9	1.2	0.8	-1.1	1.0	0.0	0.9	-1.1	-1.0	0.8	-1.1
Progressive ratio test 2 breakpoint	0.7	0.8	1.0	0.9	-1.0	1.0	-0.0	0.9	-1.0	-1.0	0.8	-1.0
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	0.3	-0.5	0.5	0.2	0.6	-0.6	-0.7	0.4	-0.6
Incentive Sensitization - Responses	1.7	1.7	2.7	-0.3	-1.1	1.4	1.5	1.7	-1.3	-1.4	1.5	-1.2
Incentive Sensitization - Breakpoint	1.7	1.7	2.8	-0.2	-1.1	1.4	1.4	1.7	-1.3	-1.4	1.5	-1.2
Sum of active levers in priming session hrs 5-6	3.3	3.2	10.5	3.2	-1.8	1.7	-1.5	0.9	-1.6	-1.5	1.3	-1.6
Progressive ratio	0.4	0.5	1.7	1.3	-0.7	0.5	-0.7	0.7	-0.5	-0.4	0.6	-0.6
Food seeking constrained by brief footshock	0.2	0.2	0.7	0.9	-0.5	-0.1	-0.8	0.2	0.2	0.3	-0.1	-0.5
Seeking ratio, punishment vs. effort	0.4	0.5	0.7	-0.8	0.6	-0.8	0.0	-0.7	0.8	0.9	-0.8	0.5
Retroperitoneal fat weight	0.3	1.1	3.2	-1.5	-0.6	0.5	1.8	1.4	-0.4	-0.4	0.8	-0.8
Reaction time number correct	0.7	1.1	3.3	-1.8	1.3	-1.0	0.8	-0.4	0.9	0.8	-0.6	1.1
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2	0.3	0.1	0.1	0.2	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.2	-0.1	0.2	0.5	0.4	-0.1	-0.2	0.5	-0.2
Reaction time num false alarms	0.1	0.1	0.5	0.7	-0.4	0.1	-0.2	0.0	0.0	-0.0	0.3	-0.4
Reaction time num false alarms AUC	0.2	0.2	1.2	1.1	-0.5	-0.0	-0.5	-0.4	0.2	0.2	0.1	-0.4
Reaction time trials correct on left	0.7	1.1	3.3	-1.8	1.3	-1.0	0.8	-0.4	0.9	0.8	-0.6	1.1
Reaction time trials on left	0.7	1.1	3.5	-1.9	1.3	-0.9	0.9	-0.3	0.9	0.7	-0.5	1.1
Reaction time mean	0.4	0.5	0.9	-0.7	0.8	-0.9	-0.1	-0.4	0.9	0.9	-0.7	0.6
Reaction time mean AUC	0.4	0.6	1.0	-0.7	0.7	-1.0	-0.1	-0.5	1.0	1.0	-0.7	0.6
Median of all reaction times	0.7	1.0	1.5	-0.7	1.0	-1.2	-0.4	-0.8	1.2	1.2	-1.0	0.9
Reaction time omissions	1.7	2.3	3.5	-0.5	-1.0	1.6	1.9	1.8	-1.6	-1.6	1.8	-1.2
Reaction time false alarm rate	0.5	0.7	3.1	1.8	-1.0	0.5	-0.7	-0.0	-0.4	-0.3	0.5	-0.9
Reaction time premature initiation rate	0.8	1.1	3.2	1.8	-1.3	1.0	-0.6	0.4	-0.8	-0.9	0.7	-1.2
Reaction time premature initiations	0.1	0.2	0.4	0.7	-0.6	0.5	-0.1	0.3	-0.3	-0.5	0.4	-0.5
Std. dev. reaction times	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.2	0.2	0.1	0.1	0.1	-0.2
Reaction time trials completed	0.7	1.1	3.5	-1.9	1.3	-0.9	0.9	-0.3	0.9	0.7	-0.5	1.1
Reaction time trials AUC	1.1	1.6	5.3	-2.3	1.6	-1.1	1.1	-0.3	1.0	0.8	-0.6	1.3
Run reversals in cocaine runway, females	1.0	1.0	2.8	-1.7	1.2	-1.0	0.7	-0.1	0.9	1.0	-0.6	0.9
Run reversals in cocaine runway, males	0.3	0.3	1.4	1.2	-0.3	0.2	-1.1	-0.3	0.2	-0.0	-0.1	-0.0
Latency to leave start box in cocaine runway	1.9	2.0	4.3	1.6	-1.3	1.6	-0.3	1.1	-2.1	-1.7	1.1	-1.3
Latency to leave start box in cocaine runway, F	1.5	1.7	3.3	1.7	-1.1	1.5	-0.7	0.8	-1.8	-1.4	1.0	-1.0
Latency to leave start box in cocaine runway, M	0.8	0.7	1.5	0.8	-0.8	0.9	0.1	0.8	-1.2	-1.2	0.6	-0.9
Std. dev. time between licks in bursts	0.6	0.8	1.3	0.3	-1.0	1.1	0.3	1.1	-0.8	-0.9	1.0	-0.8
Total sessions with >9 infusions	0.1	0.1	0.3	-0.4	0.1	0.2	0.5	0.1	-0.0	-0.0	0.3	0.2
Short access day 1 total inactive lever presses	1.2	1.3	2.0	0.1	-1.1	1.3	1.1	1.0	-1.3	-1.3	1.4	-0.9
Short access day 10 total inactive lever presses	2.7	3.0	5.0	1.3	-1.9	2.2	0.5	1.6	-2.0	-1.9	1.9	-1.6
Short access day 1 total infusions	0.2	0.2	0.5	0.1	-0.1	0.5	0.6	0.1	-0.6	-0.7	0.6	0.0
Short access day 10 total infusions	1.0	1.1	3.2	1.0	0.7	-0.9	-1.8	-1.1	0.8	0.9	-1.2	0.7
Short access total infusions	0.3	0.3	1.0	0.8	0.4	-0.4	-1.0	-0.5	0.3	0.3	-0.4	0.4
Short access day 1 locomotion	0.1	0.1	0.2	0.2	0.3	-0.1	-0.2	-0.4	-0.1	-0.1	-0.1	0.4
Short access day 10 total locomotion	0.2	0.2	0.6	0.8	0.5	0.2	-0.6	-0.4	-0.2	-0.4	-0.0	0.4
Short access total locomotion	0.3	0.4	1.0	-0.1	1.0	-0.5	-0.3	-0.7	0.4	0.4	-0.5	0.9
One hour access (0.3 mA shock)	0.3	0.3	0.6	0.1	0.7	-0.7	-0.7	-0.6	0.4	0.4	-0.8	0.5
Compulsive drug intake	0.3	0.3	1.2	-1.1	0.3	-0.2	0.8	-0.0	0.2	0.2	0.0	0.4
One hour access (shock baseline)	0.1	0.1	0.4	0.3	0.2	-0.5	-0.6	-0.2	0.3	0.3	-0.5	0.0
Social response proportion	0.1	0.1	0.3	0.6	0.1	-0.1	-0.4	-0.5	0.2	0.1	-0.4	0.1
Social responses	0.3	0.4	1.1	-0.8	0.1	-0.5	0.4	-0.0	1.0	0.9	-0.4	0.2
Social time	0.8	1.1	5.2	-2.3	0.5	-0.3	1.9	0.7	0.4	0.4	0.0	0.3
Soleus weight	0.8	2.4	3.6	0.8	-1.9	1.8	0.9	1.7	-1.5	-1.6	1.6	-1.8
Bone: stiffness	1.6	2.5	3.6	-1.7	1.7	-1.8	-0.2	-1.4	1.7	1.7	-1.9	1.4
Tibialis anterior weight	0.3	0.9	1.8	-1.3	0.8	-1.3	0.1	-0.4	0.9	1.0	-1.2	0.5
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.5	-0.6	1.2	-0.1	0.6	-0.6	-0.3	-0.4	-0.0	1.1
Time to tail flick, vehicle, after self-admin	0.5	0.5	2.2	1.5	-0.8	0.8	-0.5	0.0	-0.4	-0.4	0.6	-0.7
Time to tail flick, test, before self-admin	0.9	0.9	2.3	1.3	0.6	-0.7	-1.5	-1.1	0.9	0.8	-0.5	0.7
Time to tail flick, test, after self-admin	0.4	0.4	1.4	-0.6	0.5	-0.6	0.2	-0.1	1.1	1.2	-0.1	0.5
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	3.0	1.7	-1.0	-0.0	-1.6	-0.4	0.6	0.6	-0.3	-0.6
Delta time to tail flick, test, before/after SA	0.8	0.7	3.1	-1.8	0.7	-0.6	1.1	0.1	0.6	0.8	-0.3	0.5
Tibia length	0.2	0.6	1.2	-0.1	-0.2	-0.8	-0.8	-0.7	1.0	1.0	-1.1	-0.3
Ambulatory time before self-admin	0.1	0.1	0.2	0.4	0.1	0.1	-0.4	-0.1	-0.2	-0.3	-0.1	0.1
Ambulatory time after self-admin	1.1	1.3	2.4	1.3	-1.5	1.3	-0.2	0.9	-0.9	-1.0	1.0	-1.4
Bone: tissue strength	0.1	0.1	0.4	0.6	-0.2	-0.1	-0.4	-0.2	0.1	-0.0	-0.0	-0.1
Total heroin consumption	4.2	5.0	18.1	4.3	-1.3	2.2	-2.2	0.7	-2.5	-2.3	1.5	-1.1
Bone: trabecular number	0.1	0.2	0.3	-0.1	0.4	-0.5	-0.4	-0.4	0.3	0.4	-0.4	0.5
Bone: trabecular spacing	0.5	0.6	1.4	-0.1	-1.2	0.8	0.6	1.0	-0.5	-0.5	0.7	-1.2
Bone: trabecular thickness	1.6	1.9	3.0	-1.7	1.7	-1.7	0.1	-0.9	1.2	1.4	-1.5	1.3
Bone: trabecular tissue density	0.6	0.8	1.3	-1.1	1.1	-1.0	0.2	-0.7	1.0	0.9	-1.0	0.9
Water consumed over 24 hours	0.1	0.1	0.2	0.4	0.1	0.0	-0.4	-0.4	-0.1	0.2	-0.1	0.3
Number of responses in last shaping day	0.3	0.3	1.5	-0.9	0.0	0.2	1.2	0.2	-0.2	-0.3	0.5	0.1