LOC120097408

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120097408	0.19	0.07	0.0e+00	0.2	0.21	0.22	0.21	1.6e-18	3.1e-19	1.2e-20	1.3e-19
2	BLA	gene expression	LOC120097408	0.23	0.15	8.6e-05	0.07	0.04	0.05	0.08	1.3e-04	2.4e-03	9.0e-04	6.8e-05
3	IL	gene expression	LOC120097408	0.43	0.18	3.2e-04	0.12	0.11	0.02	0.16	7.9e-04	1.5e-03	9.3e-02	1.4e-04
4	NAcc	gene expression	LOC120097408	0.1	0.06	1.4e-06	0.02	0.05	0.05	0.04	3.7e-03	1.4e-06	3.1e-06	1.8e-05
5	PL	gene expression	LOC120097408	0.1	0.06	1.5e-07	0.05	0.07	0.05	0.06	1.9e-06	4.5e-08	3.1e-06	4.0e-07
6	RMTg	gene expression	LOC120097408	0.19	0.12	5.6e-03	0.13	0.07	0.02	0.07	2.8e-04	5.3e-03	8.3e-02	4.9e-03
7	pVTA	gene expression	LOC120097408	0.08	0.05	3.1e-03	0.08	0.04	0.01	0.05	2.8e-04	7.7e-03	7.5e-02	3.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	0.5	0.5	0.2	-0.2	0.3	0.7	0.4	-0.7
Area under the delay curve	0.3	0.3	1.1	1.1	0.5	0.0	0.2	-0.3	0.7	-0.4
BMI with tail	0.3	1.1	3.5	-1.9	-0.8	0.9	-0.5	0.3	-1.0	1.1
BMI without tail	0.5	1.0	2.2	-1.4	0.3	1.5	0.5	1.4	-0.4	-0.4
Body weight	0.1	0.6	1.7	-1.2	-0.6	0.9	-0.0	1.3	-0.3	-0.3
Weight adjusted by age	0.3	0.3	0.7	-0.8	-0.5	0.6	-0.6	0.0	-0.3	0.6
Bone surface	0.7	1.3	3.2	-0.4	0.8	0.9	1.1	1.8	0.4	-1.6
Bone volume	0.2	0.3	1.0	0.1	-0.2	0.2	0.2	1.0	0.1	-0.8
Breakpoint value in progressive ratio session	0.8	0.9	2.9	0.1	1.7	0.3	1.1	0.3	0.9	-1.0
Number of licking bursts	3.0	3.5	9.6	3.1	0.1	-2.8	-0.1	-1.6	1.9	0.7
Context. condit. distance diff. score	1.2	1.4	3.1	-1.7	-0.5	1.7	-0.4	1.3	-1.0	-1.0
Locomotion velocity, session 1	2.3	2.5	6.0	-2.4	-0.8	1.9	-0.9	0.8	-2.4	-0.1
Locomotion distance, session 1	2.8	3.7	10.3	-2.3	-1.6	1.3	-2.0	-0.5	-3.2	1.3
Locomotion velocity, session 2	2.9	3.3	5.6	-0.1	-2.2	-0.7	-2.4	-2.1	-1.6	2.3
Locomotion distance, session 2	1.7	2.4	5.0	-1.0	-1.6	0.4	-1.9	-1.2	-2.2	1.7
Locomotion velocity, session 3	0.3	0.3	0.6	0.2	-0.5	-0.2	-0.8	-0.7	-0.5	0.7
Locomotion distance, session 3	0.6	0.7	1.7	0.2	-1.0	-0.3	-1.3	-0.8	-0.7	0.9
Stereotopy head waving bouts, day 3	0.2	0.2	0.6	0.1	0.5	-0.3	0.8	0.1	0.7	0.1
Stereotopy head waving duration, day 3	0.4	0.4	1.1	-1.0	0.5	0.8	0.8	0.7	0.1	-0.3
Locomotion velocity, session 7	3.4	3.7	7.4	-2.0	1.6	2.3	1.9	2.7	0.4	-1.8
Locomotion distance, session 7	0.7	0.9	2.4	-1.5	-0.2	1.4	0.1	1.2	-0.5	-0.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.2	0.7	-0.5	0.4	-0.6	0.2	0.3
Stereotopy head waving duration, day 7	0.7	0.8	2.0	0.5	1.4	-0.7	1.3	-0.3	1.0	-0.1
Locomotion velocity, session 8	0.0	0.0	0.1	-0.0	0.3	-0.1	0.3	-0.0	0.1	0.0
Locomotion distance, session 8	0.7	1.0	2.4	-1.4	-0.7	1.2	-0.9	0.2	-1.6	0.1
Degree of sensitization distance	0.9	0.9	1.7	-1.1	0.6	1.2	0.9	1.3	0.1	-0.8
Degree of sensitization stereotypy	0.3	0.3	0.6	0.5	0.6	-0.8	0.3	-0.7	0.3	0.4
Conditioned locomotion	1.4	1.7	3.5	1.9	1.1	-1.4	1.0	-0.2	1.9	-0.7
Cocaine response after cond. corrected	1.3	1.4	3.3	-1.8	-0.3	1.8	-0.5	0.4	-1.8	0.3
Cocaine response after cond. not corrected	1.3	1.5	3.9	-1.4	-0.8	1.3	-1.0	-0.3	-2.0	0.9
Cocaine response before conditioning	1.1	1.4	2.6	1.4	-0.7	-1.6	-0.9	-1.6	0.2	1.1
Saline control response	0.2	0.3	0.7	-0.6	-0.5	0.6	-0.5	0.3	-0.8	-0.1
Bone: connectivity density	1.5	2.4	4.5	0.1	1.9	0.5	2.1	1.7	1.3	-2.0
Bone: cortical apparent density	2.0	2.6	5.4	0.8	-1.6	-1.4	-1.6	-2.3	0.2	2.3
Bone: cortical area	0.4	0.6	1.8	0.6	-0.3	0.4	-0.1	1.4	0.1	-1.3
Bone: cortical porosity	1.1	1.2	2.7	-1.4	-0.8	1.4	-0.9	0.5	-1.6	-0.3
Bone: cortical porosity	1.4	1.5	2.9	-1.5	-0.5	1.7	-0.6	1.1	-1.6	-0.9
Bone: cortical thickness	0.5	0.9	2.8	-0.1	-0.5	1.1	-0.1	1.7	-0.2	-1.3
Bone: cortical thickness	1.5	1.7	4.6	-1.1	-2.1	1.1	-1.7	0.2	-1.4	0.5
Bone: cortical tissue density	2.0	2.7	5.7	0.8	-1.6	-1.5	-1.5	-2.4	0.2	2.3
Condit. Reinf. active minus inactive responses	0.4	0.5	1.1	-0.8	0.1	1.1	0.0	0.7	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.6	-1.1	-0.1	1.3	0.1	0.9	-0.7	-0.5
Condit. Reinf. active responses	0.7	0.8	1.7	-1.0	0.3	1.3	0.3	1.1	-0.8	-0.9
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.2	0.6	-0.1	0.5	0.3	0.2	-0.5
Incentive salience index mean	0.1	0.1	0.3	-0.2	0.2	0.5	0.1	0.3	-0.5	-0.4
Condit. Reinf. lever presses	0.6	0.8	2.2	0.5	1.5	0.1	1.2	0.6	0.4	-1.0
Condit. Reinf. active minus inactive responses	2.1	2.5	4.2	-2.1	-1.7	2.0	-1.4	0.8	-2.0	-0.0
Condit. Reinf. active-inactive response ratio	2.5	2.6	4.7	-2.0	-2.2	1.6	-1.5	0.3	-1.9	0.8
Condit. Reinf. active responses	1.6	2.2	4.2	-2.0	-1.2	1.9	-1.1	1.0	-2.0	-0.6
Condit. Reinf. inactive responses	0.5	0.6	2.2	-0.3	0.6	0.6	0.1	1.0	-0.6	-1.5
Condit. Reinf. lever presses	0.2	0.3	0.7	0.4	-0.6	-0.4	-0.9	-0.5	-0.7	-0.1
Condit. Reinf. lever reinforcers received	1.6	2.3	4.6	-1.8	-1.5	1.7	-1.4	0.8	-2.2	-0.4
Conditioned reinforcement - actives	0.6	0.6	1.4	0.0	0.7	0.1	0.7	1.2	1.0	-0.8
Conditioned reinforcement - inactives	0.3	0.3	0.7	-0.7	-0.1	0.8	0.2	0.9	0.1	-0.6
Conditioned locomotion	2.8	3.4	6.9	-0.1	2.6	0.9	2.4	1.9	1.8	-1.9
Patch foraging indifference point 0 sec	0.4	0.7	2.6	0.5	1.6	-0.2	1.0	0.3	0.4	-0.8
Patch foraging indifference point AUC	2.0	2.3	5.7	-1.9	0.5	2.4	0.3	1.6	-1.4	-1.3
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.3	0.8	0.4	0.6	0.3	0.2	-0.4
Delay disc. indifference point, 16s delay	1.0	1.0	1.9	-0.5	1.4	1.0	1.1	0.9	0.5	-1.2
Delay disc. indifference point, 2s delay	0.8	0.9	2.2	1.5	-0.1	-1.0	-0.3	-1.3	0.7	0.9
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	0.1	0.4	0.4	0.3	0.5	0.7	-0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.6	0.1	0.1	0.2	-0.1	0.8	-0.3
Delay disc. indifference point, 8s delay	0.4	0.4	1.8	1.3	-0.2	-0.3	-0.4	-0.6	0.4	-0.0
Indifference point function ln k	2.2	3.1	6.4	2.5	-0.9	-2.5	-1.0	-2.0	0.9	1.5
Indifference point function log k	2.2	3.1	6.4	2.5	-0.9	-2.5	-1.0	-2.0	0.9	1.5
Patch foraging total patch changes 0 sec	0.3	0.5	1.5	0.7	1.2	-0.4	0.6	-0.0	0.4	-0.7
Patch foraging total patch changes 12 sec	0.9	1.1	1.7	-1.3	1.2	1.2	1.0	1.0	-0.5	-1.0
Patch foraging total patch changes 18 sec	0.4	0.5	1.1	-1.0	1.0	0.8	0.3	-0.1	-0.7	0.2
Patch foraging total patch changes 24 sec	0.7	0.8	2.8	-0.5	1.7	0.7	0.9	0.6	-0.3	-1.0
Patch foraging total patch changes 6 sec	1.3	1.9	4.3	-0.8	1.4	1.2	1.3	1.8	0.1	-2.1
Patch foraging time to switch 0 sec	0.6	1.0	2.9	0.5	1.0	-0.8	1.4	0.1	1.7	0.1
Patch foraging water rate 0 sec	0.8	1.3	3.6	0.6	-1.4	-0.4	-1.9	-1.1	-1.3	0.4
Patch foraging water rate 12 sec	1.7	2.6	8.2	2.9	-1.0	-1.9	-1.3	-1.5	1.1	0.4
Patch foraging water rate 18 sec	0.9	1.2	3.7	0.9	-1.9	-1.0	-1.7	-0.5	-0.2	0.1
Patch foraging water rate 24 sec	0.6	0.8	1.7	1.0	-1.3	-1.0	-1.2	-0.7	0.2	0.4
Patch foraging water rate 6 sec	2.2	3.2	10.3	3.2	0.8	-2.1	0.5	-0.1	2.3	-1.3
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	5.0	-2.1	-1.5	2.2	-0.6	1.7	-1.7	-1.3
Distance traveled before self-admin	2.0	2.1	6.5	2.4	-0.7	-1.5	-0.1	-0.2	2.5	-0.2
Distance traveled after self-admin	2.1	2.3	6.0	1.8	1.5	-0.9	1.5	0.5	2.4	-1.2
Extensor digitorum longus weight	0.1	0.6	1.4	-0.4	-0.5	0.9	-0.4	1.2	-0.7	-0.9
Bone: elastic displacement	1.1	1.3	3.2	-1.5	0.3	1.8	0.7	1.4	-0.3	-0.9
Bone: elastic work	1.7	2.3	5.0	-1.7	-0.1	2.2	0.5	2.2	-0.5	-1.5
Bone: endosteal estimation	0.3	0.6	2.0	1.4	-0.3	-1.2	-0.3	-0.5	0.6	0.1
Bone: endosteal perimeter	0.3	0.5	1.0	1.0	0.7	-0.7	0.6	0.5	0.8	-0.8
Epididymis fat weight	0.4	1.0	2.7	-0.3	-1.3	-0.1	-1.6	-0.7	-1.1	0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.4	0.5	0.5	0.2	0.4	-0.4	-0.6
Delta time in open arm before/after self-admin	1.3	1.3	2.1	-0.6	-1.3	0.3	-1.5	-1.1	-1.1	1.4
Diff in mean of infusions in LGA sessions	0.1	0.2	0.6	-0.3	0.8	0.3	0.4	0.3	0.2	-0.1
Delay discount exponential model param	0.2	0.3	1.1	-1.0	-0.2	-0.0	0.0	0.5	-0.6	0.3
Extinction: sum of active levers before priming	0.6	0.6	1.3	-0.8	0.5	1.1	0.3	0.8	-0.1	-1.1
Active lever presses in extinction session 6	2.9	2.8	7.0	-2.5	0.4	2.6	-0.1	1.5	-1.5	-1.3
Bone: final force	0.2	0.3	0.6	0.7	-0.7	0.2	-0.6	0.7	-0.0	-0.5
Bone: final moment	0.2	0.4	0.8	0.6	-0.8	0.4	-0.6	0.9	-0.1	-0.7
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.3	0.2	-0.1	-0.2
Glucose	0.6	0.9	2.2	-1.5	-0.6	1.2	-0.5	0.1	-1.4	0.2
Heart weight	1.1	1.5	4.0	-1.3	-2.0	0.8	-1.5	0.7	-1.2	-0.2
Delay discount hyperbolic model param	0.3	0.3	1.3	-1.1	-0.0	0.1	0.2	0.6	-0.6	0.1
Intermittent access intake day 1-15 change	0.6	0.6	1.5	-0.4	0.5	1.0	0.4	1.2	-0.4	-1.1
Intermittent access intake escalation	0.7	0.7	1.5	-0.5	0.6	1.0	0.5	1.2	-0.4	-1.1
Intermittent access intake escalation 2	1.0	1.0	2.0	-0.3	1.2	0.8	1.0	1.3	-0.0	-1.4
Intermitt. access day 1 inactive lever presses	1.0	1.1	3.2	1.8	0.6	-0.8	0.3	0.2	1.5	-1.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	0.6	0.6	0.3	0.0	0.4	0.2	-0.8
Intermitt. access escalation Index	2.0	1.8	3.0	-1.0	-1.7	0.7	-1.6	-0.7	-1.7	1.4
Intermittent access day 1 total infusions	0.5	0.6	0.9	-0.7	1.0	1.0	0.9	0.7	0.7	-0.4
Intermittent access day 15 total infusions	1.4	1.6	2.6	-0.7	1.4	1.4	1.3	1.6	0.6	-1.5
Intermittent access terminal intake (last 3 days)	2.2	2.4	3.9	-0.5	1.7	1.4	1.7	2.0	1.0	-2.0
Intermittent access total infusions	1.1	1.2	2.1	-0.6	1.0	1.3	1.1	1.4	0.8	-1.3
Intermittent access day 1 locomotion	1.0	1.0	2.1	0.2	1.4	0.1	1.3	0.8	1.4	-0.7
Intermittent access day 15 total locomotion	1.9	2.0	3.8	-0.6	2.0	1.0	1.8	1.7	1.0	-1.4
Intermittent access total locomotion	2.8	3.2	6.4	0.4	2.5	0.3	2.4	1.7	2.2	-1.6
Intermittent access standard deviation	1.6	1.7	3.2	0.6	1.8	0.0	1.7	1.3	1.4	-1.3
Left kidney weight	0.3	0.9	1.7	-1.0	0.4	1.1	0.1	1.3	-0.8	-1.2
Right kidney weight	0.4	1.1	3.8	0.3	0.6	0.4	0.6	1.6	0.5	-1.9
Cocaine induced anxiety	0.9	1.1	2.4	1.6	-0.7	-1.2	-0.4	-1.0	1.0	1.0
Post-drug Anxiety	2.9	3.2	5.8	2.4	-1.6	-2.2	-1.1	-1.8	1.3	1.7
Baseline Anxiety	0.4	0.4	0.9	0.9	-0.5	-0.9	-0.7	-0.6	0.0	0.0
Tail length	0.7	2.2	5.4	0.7	1.2	0.5	1.5	2.0	1.5	-2.3
Length with tail	0.2	0.6	1.8	0.8	-0.2	-0.2	0.2	1.0	0.9	-1.3
Length without tail	0.8	1.7	3.7	1.3	-1.4	-1.9	-1.0	-1.4	0.5	1.3
Times rat made contact with spout	1.2	1.3	3.6	0.0	-1.7	-0.1	-1.9	-0.9	-1.1	0.9
Lifetime Intake	0.3	0.4	0.9	-0.5	0.4	1.0	0.4	0.8	0.4	-0.5
Liver weight, left	0.2	0.4	0.8	0.4	0.4	-0.9	0.6	-0.1	0.8	0.5
Liver weight, right	0.6	0.9	1.9	-0.0	1.1	0.2	1.4	1.2	1.0	-1.0
Locomotor activity	0.7	1.2	3.8	1.9	0.4	-1.5	0.2	-0.5	1.2	-0.6
Locomotor testing distance	0.5	0.8	2.4	1.6	0.6	-1.1	0.4	-0.2	1.0	-0.7
Locomotor testing rearing	1.0	1.6	4.5	2.1	0.8	-1.5	0.4	-0.4	1.7	-0.7
Locomotion in novel chamber	0.3	0.4	1.0	-0.9	-0.5	1.0	-0.2	0.6	-0.4	-0.1
Locomotion in novel chamber post-restriction	1.4	1.7	3.5	-1.4	-1.3	1.6	-1.0	1.0	-1.9	-0.7
Fecal boli incidents, locomotor time 1	0.4	0.4	1.6	1.3	0.4	-0.9	-0.0	-0.3	0.6	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.8	-1.3	0.1	1.3	0.0	0.4	-0.6	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.7	-0.2	0.8	-0.2	0.1	-0.2	-0.4	0.0
Bouts of movement, locomotor time 1	0.8	0.8	1.5	0.5	-1.1	-1.0	-1.0	-1.0	-0.1	1.2
Total resting periods, locomotor time 1	0.9	1.0	2.0	0.6	-1.0	-1.2	-0.8	-1.1	0.1	1.4
Rest time, locomotor task time 1	0.6	0.7	1.5	0.8	-0.5	-1.2	-0.3	-1.0	0.3	1.2
Distance moved, locomotor task time 1	0.1	0.2	0.6	0.2	0.8	-0.2	0.4	-0.2	0.3	-0.3
Vertical activity count, locomotor time 1	0.4	0.5	1.2	-0.9	1.1	0.7	0.8	-0.0	-0.0	-0.3
Time >=10cm from walls, locomotor time 2	1.5	1.6	3.3	-1.3	1.8	1.6	1.3	0.9	-0.7	-1.0
Bouts of movement, locomotor time 2	0.6	0.6	1.2	-1.1	0.4	1.1	0.6	0.9	-0.5	-0.7
Total resting periods, locomotor time 2	0.6	0.6	1.5	-1.2	0.1	1.2	0.4	0.8	-0.6	-0.5
Rest time, locomotor task time 2	0.9	1.0	2.4	0.7	-0.9	-1.4	-0.7	-1.1	0.1	1.5
Distance moved, locomotor task time 2	1.7	1.9	3.7	-0.5	1.9	0.9	1.7	1.5	0.8	-1.7
Vertical activity count, locomotor time 2	0.7	0.8	1.9	-0.7	1.4	0.9	1.1	0.6	0.4	-0.9
Light reinforcement 1	0.5	0.9	2.1	-0.1	1.4	0.3	1.3	1.0	0.2	-1.2
Light reinforcement 2	10.2	13.7	28.6	1.9	5.3	-0.3	5.0	2.7	3.7	-4.1
Bone: marrow area	0.3	0.7	2.2	1.5	-0.2	-1.3	-0.3	-0.6	0.6	0.1
Bone: maximum diameter	0.1	0.2	0.6	0.2	-0.1	0.3	-0.0	0.8	-0.2	-0.7
Bone: maximum force	0.3	0.5	1.5	0.6	-1.2	0.3	-1.0	0.6	-0.4	-0.3
Bone: maximum moment	0.3	0.6	1.5	0.5	-1.2	0.4	-1.0	0.7	-0.4	-0.5
Mean time between licks in bursts	1.0	1.5	3.1	0.1	1.6	0.6	1.8	1.2	1.0	-1.3
Mean num. licks in bursts	2.7	3.2	7.2	-2.7	-1.3	2.4	-1.2	0.7	-2.5	0.1
Cd content in liver	3.6	3.9	7.1	-1.6	-2.7	0.8	-2.3	-1.3	-2.3	2.3
Co content in liver	1.8	2.1	3.0	-1.7	-1.7	1.0	-1.3	-0.7	-1.7	1.7
Cu content in liver	0.6	0.7	1.3	1.0	1.1	-0.2	0.9	0.4	0.9	-1.1
Fe content in liver	0.2	0.3	0.9	0.1	-0.2	-0.6	-0.1	-0.9	0.1	0.8
K content in liver	1.3	1.3	4.3	2.1	0.2	-1.6	0.2	-0.4	1.2	-0.3
Mg content in liver	0.1	0.1	0.4	0.7	-0.2	-0.4	-0.1	0.1	0.2	-0.1
Mn content in liver	1.2	1.4	2.4	0.9	-1.1	-1.3	-1.1	-1.5	-0.3	1.5
Na content in liver	1.2	1.3	3.2	1.0	1.8	-0.7	1.4	0.6	1.0	-1.0
Rb content in liver	0.2	0.3	0.9	-0.8	-0.3	1.0	0.1	0.4	-0.3	-0.0
Se content in liver	0.5	0.6	1.5	0.3	1.2	-0.5	1.2	-0.1	1.1	-0.2
Sr content in liver	0.3	0.3	1.1	0.5	1.0	-0.3	0.5	0.1	0.1	-0.6
Zn content in liver	0.9	0.9	2.1	-1.5	-0.6	1.4	-0.4	0.4	-1.4	-0.0
Bone: minimum diameter	0.2	0.3	1.2	1.1	-0.0	-0.4	0.2	0.4	0.9	-0.4
Time in familiar zone, hab. session 1	0.4	0.4	1.2	0.3	0.1	-0.5	-0.1	-1.0	-0.0	1.1
Time in novel zone, hab. session 1	2.0	1.9	4.7	-1.6	0.3	1.8	0.7	2.2	-0.2	-1.6
Total zone transitions, hab. session 1	1.6	2.2	4.5	-1.2	-1.5	0.7	-1.8	-1.2	-2.1	1.6
Total locomotion distance, hab. session 1	1.0	1.4	2.7	-0.8	-1.0	0.1	-1.4	-1.2	-1.6	1.4
Locomotion velocity, hab. session 1	1.2	1.7	3.0	-0.1	-1.2	-0.5	-1.7	-1.6	-1.5	1.5
Time in familiar zone, hab. session 2	1.2	1.2	2.6	0.5	1.6	0.2	1.6	0.7	1.4	-1.0
Time in novel zone, hab. session 2	1.5	1.5	3.0	-0.9	-1.6	0.3	-1.7	-0.4	-1.7	0.8
Total zone transitions, hab. session 2	1.4	1.8	4.8	-1.0	-1.3	0.7	-1.7	-0.8	-2.2	1.1
Total locomotion distance, hab. session 2	0.3	0.4	1.3	-0.1	-0.6	0.1	-1.0	-0.5	-1.1	0.3
Locomotion velocity, hab. session 2	0.5	0.6	1.5	-0.1	-0.8	0.0	-1.2	-0.7	-1.2	0.5
Novel to familiar place preference ratio	3.3	3.4	7.6	-2.8	-1.1	2.5	-0.8	1.8	-1.9	-0.8
Novelty place preference	3.2	3.3	7.3	-2.7	-0.9	2.6	-0.5	2.0	-1.7	-1.0
Time in novel zone, NPP test	3.9	4.0	9.0	-3.0	-0.6	2.9	-0.3	2.3	-1.7	-1.3
Total zone transitions, NPP test	1.2	1.7	3.0	0.2	-1.4	-0.6	-1.7	-1.5	-1.3	1.5
Total locomotion distance, NPP test	0.7	0.9	1.6	0.2	-0.9	-0.5	-1.3	-1.1	-1.1	1.1
Locomotion velocity, NPP test	0.8	1.1	1.7	0.7	-1.0	-0.9	-1.3	-1.3	-0.7	1.2
Intraocular pressure	3.0	4.1	9.8	-2.9	-0.6	3.1	0.1	2.8	-1.2	-1.1
Delta distance traveled before/after self-admin	0.9	1.0	2.3	-0.8	1.5	0.9	1.3	0.8	-0.4	-0.7
Delta ambulatory time before/after self-admin	0.7	0.8	1.4	-1.2	1.0	1.0	1.0	0.6	-0.6	-0.5
Parametrial fat weight	0.8	1.6	3.6	-1.4	-0.4	1.9	-0.1	1.7	-0.7	-1.5
Pavlov. Cond. lever latency	1.8	2.2	4.0	-1.5	-2.0	0.2	-1.8	-0.7	-1.5	1.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	0.2	0.8	0.5	0.8	0.3	0.3	-0.8
Pavlov. Cond. change in total contacts	0.8	0.9	1.7	-0.3	1.1	0.8	1.3	0.9	0.4	-1.1
Pavlov. Cond. index score	1.3	1.6	3.4	1.1	1.8	0.0	1.6	0.5	1.2	-1.5
Pavlov. Cond. latency score	1.4	1.8	3.6	1.3	1.9	-0.2	1.7	0.4	1.3	-1.4
Pavlov. Cond. lever contacts	1.4	1.7	2.9	1.6	1.7	-0.3	1.5	0.4	1.3	-1.4
Pavlov. Cond. magazine entry number	0.9	1.2	2.2	0.3	-1.5	-1.0	-1.3	-1.0	-0.3	1.4
Pavlov. Cond. intertrial magazine entries	2.3	2.8	6.1	-1.7	-2.0	1.2	-1.9	-0.2	-2.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.3	1.0	1.8	0.0	1.7	0.4	1.2	-1.4
Pavlov. Cond. response bias	0.7	0.8	1.8	0.9	1.3	0.0	1.2	0.1	0.8	-1.0
Pavlov. Cond. lever latency	0.3	0.4	1.2	-1.1	0.2	0.9	0.3	0.8	-0.1	0.0
Pavlov. Cond. magazine entry latency	1.9	2.2	6.2	2.5	0.4	-2.2	0.2	-1.2	1.5	0.2
Pavlov. Cond. change in total contacts	0.4	0.6	1.5	0.8	1.0	-0.3	0.7	0.5	0.4	-1.2
Pavlov. Cond. index score	1.0	1.3	3.7	1.9	0.1	-1.8	0.0	-1.1	0.9	0.1
Pavlov. Cond. latency score	1.3	1.6	4.4	2.1	0.0	-2.0	-0.1	-1.2	1.0	0.3
Pavlov. Cond. lever contacts	0.3	0.5	0.9	0.9	-0.4	-0.9	-0.6	-1.0	-0.1	0.3
Pavlov. Cond. magazine entry number	1.1	1.3	3.8	-2.0	0.1	1.8	0.1	1.0	-1.0	-0.3
Pavlov. Cond. intertrial magazine entries	1.2	1.5	3.1	-1.8	-1.2	1.7	-0.8	0.8	-1.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	3.8	2.0	0.3	-1.8	0.1	-1.1	0.9	0.1
Pavlov. Cond. response bias	0.3	0.4	1.3	1.1	-0.0	-0.9	-0.2	-0.5	0.2	-0.3
Time in closed arm before self-admin	0.2	0.2	1.0	1.0	-0.3	-0.2	-0.2	-0.0	0.4	-0.2
Time in closed arm after self-admin	1.3	1.4	2.6	1.3	1.3	-0.1	1.2	1.0	1.2	-1.6
Time in open arm before self-admin	0.9	0.9	2.7	-1.6	0.5	1.4	0.1	0.4	-1.1	-0.3
Time in open arm after self-admin	2.9	3.2	5.5	-2.1	-1.4	0.9	-1.8	-1.5	-2.4	2.1
Bone: periosteal estimation	0.1	0.3	0.9	1.0	-0.5	-0.4	-0.3	0.5	0.2	-0.6
Bone: periosteal perimeter	0.3	0.5	1.7	1.3	0.0	-0.6	0.2	0.7	0.8	-0.9
Bone: post-yield work	1.1	1.5	2.5	1.0	-1.3	-0.9	-1.5	-1.6	-0.5	1.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.3	0.9	0.4	0.7	0.5	0.7	-0.2
Progressive ratio test 1 breakpoint	0.4	0.4	1.1	-0.2	1.1	0.4	0.8	0.6	0.8	-0.3
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.1	-0.5	0.6	0.9	0.3	1.0	0.0	-1.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	-0.6	0.5	0.6	0.5	0.9	0.4	-0.6
Progressive ratio test 2 breakpoint	0.3	0.4	0.8	-0.7	0.5	0.7	0.5	0.9	0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.3	0.3	0.2	0.6	-0.0	0.9	0.3	-1.2
Incentive Sensitization - Responses	0.2	0.2	0.6	-0.8	0.1	0.5	-0.2	0.3	-0.5	-0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	-0.8	0.2	0.6	-0.1	0.3	-0.6	-0.3
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.7	-1.6	0.7	1.6	0.3	0.4	-0.9	-0.5
Progressive ratio	1.0	1.2	3.6	-0.3	0.9	1.2	0.8	1.2	-0.1	-1.9
Food seeking constrained by brief footshock	1.0	1.2	3.6	0.2	-1.9	-0.3	-1.6	-1.0	-0.7	0.9
Seeking ratio, punishment vs. effort	2.5	3.1	6.1	0.6	-2.2	-1.4	-2.0	-1.9	-0.5	2.5
Retroperitoneal fat weight	1.0	3.3	7.7	-2.8	-1.8	2.1	-1.5	0.6	-2.1	0.4
Reaction time number correct	1.7	2.5	4.6	0.8	-1.6	-1.3	-1.9	-2.1	-0.8	1.9
Reaction time mean minus median	0.1	0.2	0.7	-0.3	-0.2	-0.1	-0.3	-0.6	-0.1	0.8
Reaction time mean minus median AUC	0.4	0.6	1.4	0.5	-0.3	-0.8	-0.6	-1.2	0.0	1.1
Reaction time num false alarms	1.7	2.3	5.2	-2.3	-1.4	1.5	-1.2	0.2	-2.3	0.6
Reaction time num false alarms AUC	1.6	2.2	5.5	-2.3	-1.2	1.4	-1.0	0.2	-2.2	0.6
Reaction time trials correct on left	1.7	2.5	4.6	0.8	-1.6	-1.3	-1.9	-2.1	-0.8	1.9
Reaction time trials on left	1.6	2.3	4.2	0.7	-1.6	-1.1	-1.9	-2.0	-0.8	1.8
Reaction time mean	0.6	0.9	2.3	-0.8	1.5	0.6	1.3	0.8	0.6	-0.6
Reaction time mean AUC	0.6	0.8	2.1	-0.4	1.4	0.4	1.3	0.7	0.7	-0.5
Median of all reaction times	1.2	1.6	4.2	-0.7	2.0	0.7	1.8	1.2	0.8	-1.0
Reaction time omissions	3.6	4.9	8.4	-2.8	1.8	2.9	2.0	2.7	-0.2	-2.0
Reaction time false alarm rate	1.2	1.7	5.2	-2.3	-0.2	1.7	0.1	1.2	-1.4	-0.4
Reaction time premature initiation rate	1.2	1.6	3.5	1.3	0.6	-0.5	1.1	1.4	1.6	-1.9
Reaction time premature initiations	0.6	0.8	2.6	1.6	-0.3	-1.1	0.0	0.1	1.1	-0.7
Std. dev. reaction times	0.1	0.2	0.8	-0.9	0.2	0.6	0.2	0.2	-0.2	0.1
Reaction time trials completed	1.6	2.3	4.2	0.7	-1.6	-1.1	-1.9	-2.0	-0.8	1.8
Reaction time trials AUC	1.7	2.5	4.4	0.6	-1.7	-1.1	-2.0	-2.1	-0.9	1.9
Run reversals in cocaine runway, females	0.9	0.9	1.8	-0.8	-1.4	0.2	-0.8	-0.8	-0.9	1.3
Run reversals in cocaine runway, males	0.5	0.5	0.8	0.7	-0.3	-0.8	-0.7	-0.9	-0.5	0.8
Latency to leave start box in cocaine runway	0.6	0.7	1.3	0.3	1.1	-1.0	1.0	-0.8	0.4	0.7
Latency to leave start box in cocaine runway, F	0.7	0.7	2.9	-0.0	1.7	-0.5	1.3	0.3	0.5	-0.1
Latency to leave start box in cocaine runway, M	0.5	0.5	1.2	0.4	0.7	-0.7	0.8	-1.1	0.3	0.7
Std. dev. time between licks in bursts	0.6	0.8	2.0	1.4	1.0	-0.9	0.6	-0.9	0.7	0.1
Total sessions with >9 infusions	0.2	0.2	0.5	0.0	-0.1	0.5	0.1	0.7	0.4	-0.6
Short access day 1 total inactive lever presses	0.5	0.6	1.2	-0.6	0.7	0.7	1.1	0.8	0.7	-0.5
Short access day 10 total inactive lever presses	0.4	0.4	1.8	1.4	-0.1	-0.2	-0.4	-0.2	0.4	-0.7
Short access day 1 total infusions	1.6	1.7	3.6	0.3	-1.9	-0.4	-1.6	-1.4	-0.5	1.9
Short access day 10 total infusions	0.2	0.2	0.8	0.3	0.4	-0.1	0.5	0.1	0.9	-0.1
Short access total infusions	0.1	0.2	0.5	-0.4	-0.3	0.7	-0.3	-0.1	-0.1	0.4
Short access day 1 locomotion	0.3	0.3	0.7	0.6	0.4	0.2	0.4	0.5	0.9	-0.6
Short access day 10 total locomotion	1.9	2.1	4.6	1.0	2.2	-0.4	1.7	1.2	1.4	-1.7
Short access total locomotion	1.6	1.7	3.3	-0.0	1.7	1.0	1.3	1.5	0.7	-1.8
One hour access (0.3 mA shock)	0.9	1.0	2.3	-0.7	1.0	1.1	1.0	1.5	0.5	-1.0
Compulsive drug intake	0.5	0.5	1.6	0.4	-1.3	-0.1	-1.1	-0.2	-0.5	0.5
One hour access (shock baseline)	1.6	1.8	3.1	-0.8	1.4	1.1	1.6	1.8	1.0	-1.4
Social response proportion	1.0	1.1	2.8	1.2	-0.8	-1.1	-1.0	-1.7	-0.3	0.8
Social responses	1.0	1.3	2.5	0.6	-1.5	-0.7	-1.6	-1.5	-0.8	0.8
Social time	0.1	0.2	0.5	0.4	-0.3	-0.2	-0.7	-0.6	-0.4	0.1
Soleus weight	0.2	0.5	1.1	1.0	0.5	-0.4	0.5	0.7	0.6	-1.1
Bone: stiffness	0.6	0.9	2.6	1.6	-1.0	-1.0	-1.1	-0.5	0.1	0.3
Tibialis anterior weight	0.2	0.6	2.3	-0.5	-0.1	0.8	0.3	1.5	-0.0	-0.8
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	-0.4	1.1	0.6	1.0	0.7	1.1	-0.7
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.4	-1.6	-0.5	0.6	-0.5	0.2	-0.4	0.7
Time to tail flick, test, before self-admin	1.3	1.3	3.3	0.1	1.8	0.6	1.4	0.9	0.4	-1.6
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.7	0.8	-0.8	0.2	-0.8	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	3.4	-0.5	-1.8	-0.7	-1.5	-0.9	-1.0	1.7
Delta time to tail flick, test, before/after SA	0.5	0.4	1.1	0.2	-0.7	-0.6	-0.7	-0.8	0.0	1.0
Tibia length	0.3	1.0	2.3	-1.3	-0.7	1.5	-0.5	0.9	-1.1	-0.3
Ambulatory time before self-admin	1.3	1.4	4.5	1.9	-0.5	-1.0	-0.0	-0.1	2.1	-0.2
Ambulatory time after self-admin	1.0	1.1	3.0	0.8	1.0	-0.1	1.4	0.7	1.7	-1.1
Bone: tissue strength	0.2	0.2	0.5	-0.2	-0.1	0.7	-0.1	0.6	-0.2	-0.4
Total heroin consumption	0.8	1.0	2.1	1.1	1.2	-0.1	0.7	0.3	1.2	-1.4
Bone: trabecular number	0.6	0.9	1.5	0.3	1.0	-0.1	1.2	0.9	1.1	-1.2
Bone: trabecular spacing	0.7	0.9	1.8	-0.9	0.6	1.3	0.5	1.4	-0.3	-1.0
Bone: trabecular thickness	0.1	0.1	0.5	0.3	-0.7	-0.5	-0.2	0.1	0.2	0.2
Bone: trabecular tissue density	0.7	1.0	1.6	1.1	-1.1	-0.8	-1.2	-1.2	0.1	0.8
Water consumed over 24 hours	0.5	0.6	1.2	0.8	-0.6	-0.8	-1.1	-1.0	-0.3	0.5
Number of responses in last shaping day	0.6	0.6	1.6	-0.8	-0.5	1.3	-0.1	1.1	-0.5	-0.3