Hub : Genes

LOC120097381

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression LOC120097381 0.66 0.16 0.0e+00 0.23 0.25 0.35 0.29 2.9e-10 6.6e-11 1.2e-15 7.6e-13
2 RMTg gene expression LOC120097381 0.37 0.15 3.9e-07 0.11 0.14 0.11 0.15 7.2e-04 1.6e-04 9.8e-04 1.1e-04
3 IL gene expression LOC120097381 0.5 0.15 1.2e-11 0.34 0.39 0.37 0.38 5.1e-09 1.9e-10 6.3e-10 5.2e-10
4 PL gene expression LOC120097381 0.35 0.11 0.0e+00 0.33 0.39 0.39 0.4 9.7e-37 2.7e-45 1.1e-45 7.2e-46
5 Eye gene expression LOC120097381 0.43 0.18 1.4e-03 0.06 0.12 0.07 0.09 4.6e-02 6.3e-03 3.0e-02 1.8e-02
6 OFC gene expression LOC120097381 0.6 0.12 4.4e-15 0.39 0.51 0.44 0.51 2.8e-10 4.1e-14 7.1e-12 3.6e-14
7 Liver gene expression LOC120097381 0.27 0.1 0.0e+00 0.19 0.18 0.19 0.19 6.6e-21 4.6e-20 1.9e-20 2.0e-20
8 LHb gene expression LOC120097381 0.55 0.14 3.0e-13 0.45 0.39 0.4 0.42 3.5e-12 2.9e-10 1.3e-10 4.3e-11
9 pVTA gene expression LOC120097381 0.21 0.09 0.0e+00 0.23 0.25 0.23 0.23 2.1e-18 6.1e-20 1.6e-18 1.4e-18
10 BLA gene expression LOC120097381 0.12 0.07 4.1e-06 0.06 0.11 0.09 0.08 2.5e-04 3.2e-06 2.7e-05 4.5e-05
11 NAcc gene expression LOC120097381 0.32 0.12 0.0e+00 0.31 0.38 0.38 0.38 3.1e-48 2.3e-61 1.9e-61 2.3e-61
12 Brain gene expression LOC120097381 0.04 0.03 2.6e-03 0.03 0.03 0.03 0.03 8.3e-04 2.2e-03 1.2e-03 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.93.5-1.6-0.8-1.3-1.4-0.8-1.6-0.9-1.0-1.2-1.6-1.8-1.9
Area under the delay curve0.10.10.6-0.10.2-0.0-0.10.3-0.10.30.3-0.3-0.4-0.3-0.8
BMI with tail3.712.822.4-4.2-2.8-3.5-3.8-2.1-3.9-2.6-2.4-3.4-4.2-4.4-4.7
BMI without tail1.54.67.5-2.3-1.7-2.1-2.3-1.1-2.3-1.4-1.5-2.4-2.7-2.5-2.7
Body weight3.515.219.8-4.4-3.8-4.2-4.2-3.4-4.0-3.7-3.6-4.2-4.4-3.6-2.9
Weight adjusted by age1.01.62.6-1.4-1.4-1.4-1.2-1.6-1.2-1.4-1.4-1.2-1.1-0.9-0.1
Bone surface6.011.014.8-3.8-3.1-3.5-3.5-3.3-3.6-3.2-3.1-3.0-3.4-3.5-2.6
Bone volume2.85.07.6-2.7-1.8-2.2-2.4-2.0-2.5-1.8-1.8-1.8-2.2-2.8-2.5
Breakpoint value in progressive ratio session3.74.45.3-2.2-2.2-2.2-2.2-2.2-2.3-2.2-2.2-1.9-1.9-2.1-1.4
Number of licking bursts0.30.50.8-0.9-0.8-0.7-0.8-0.8-0.9-0.6-0.8-0.5-0.6-0.6-0.6
Context. condit. distance diff. score1.92.23.41.61.71.61.51.81.51.71.81.41.31.10.5
Locomotion velocity, session 10.10.10.60.40.10.10.30.20.30.10.0-0.20.00.80.8
Locomotion distance, session 10.91.12.0-1.1-0.7-1.0-1.1-0.4-1.2-0.7-0.8-1.3-1.4-1.1-1.3
Locomotion velocity, session 23.43.94.9-2.1-1.8-2.1-2.1-1.7-2.2-1.8-2.0-2.1-2.2-1.8-1.6
Locomotion distance, session 21.01.42.3-1.2-1.0-1.2-1.3-0.7-1.4-0.9-1.0-1.5-1.5-1.1-1.2
Locomotion velocity, session 30.10.10.6-0.10.20.00.00.6-0.10.30.3-0.1-0.3-0.1-0.7
Locomotion distance, session 30.00.00.10.1-0.00.10.10.20.00.00.10.10.10.20.0
Stereotopy head waving bouts, day 30.40.51.40.51.00.50.51.20.70.91.10.20.00.5-0.4
Stereotopy head waving duration, day 30.60.71.70.61.20.70.61.10.91.01.30.60.40.4-0.3
Locomotion velocity, session 70.40.42.3-0.20.60.1-0.20.7-0.30.70.50.0-0.3-0.7-1.5
Locomotion distance, session 70.10.10.3-0.10.1-0.1-0.20.4-0.20.00.1-0.5-0.5-0.1-0.5
Stereotopy head waving bouts, day 70.20.21.5-0.50.2-0.1-0.3-0.1-0.40.20.10.2-0.2-0.8-1.2
Stereotopy head waving duration, day 71.21.53.0-1.4-0.8-1.1-1.3-1.1-1.3-0.8-0.9-0.8-1.1-1.7-1.7
Locomotion velocity, session 80.60.71.3-0.6-1.1-0.9-0.6-0.8-0.6-1.1-1.1-1.1-0.80.20.7
Locomotion distance, session 80.10.20.60.10.60.20.10.70.10.60.60.2-0.1-0.1-0.7
Degree of sensitization distance0.10.10.4-0.30.0-0.3-0.40.2-0.3-0.0-0.0-0.5-0.6-0.4-0.7
Degree of sensitization stereotypy1.01.12.2-1.2-0.8-0.9-1.1-1.0-1.2-0.7-0.8-0.5-0.8-1.5-1.5
Conditioned locomotion1.41.62.2-1.3-1.4-1.4-1.2-1.4-1.2-1.5-1.4-1.5-1.4-0.7-0.4
Cocaine response after cond. corrected1.51.82.81.51.41.41.51.71.41.41.31.01.01.50.9
Cocaine response after cond. not corrected1.11.32.01.21.21.11.31.41.21.21.10.80.91.30.8
Cocaine response before conditioning0.91.01.5-1.1-1.1-1.0-1.1-1.2-1.1-1.1-1.0-0.7-0.7-1.1-0.7
Saline control response3.64.86.6-2.1-2.5-2.4-2.1-2.3-2.1-2.5-2.6-2.6-2.3-1.3-0.3
Bone: connectivity density3.45.46.7-2.6-2.1-2.4-2.4-1.9-2.5-2.2-2.1-2.3-2.6-2.5-2.0
Bone: cortical apparent density0.00.10.10.1-0.3-0.0-0.2-0.3-0.1-0.4-0.4-0.10.10.00.3
Bone: cortical area0.81.31.8-1.3-1.4-1.2-1.1-1.3-1.3-1.1-1.3-0.9-1.0-0.9-0.5
Bone: cortical porosity0.30.30.6-0.7-0.4-0.6-0.6-0.4-0.5-0.3-0.3-0.6-0.7-0.8-0.6
Bone: cortical porosity0.70.81.1-1.0-0.8-1.0-1.0-0.8-0.8-0.7-0.6-1.0-1.1-1.0-0.7
Bone: cortical thickness2.13.47.0-1.4-2.6-1.9-1.5-2.2-1.8-2.2-2.6-2.0-1.5-0.50.6
Bone: cortical thickness0.40.41.10.0-1.0-0.4-0.1-0.5-0.3-0.8-1.0-0.8-0.30.51.1
Bone: cortical tissue density0.10.10.3-0.0-0.5-0.2-0.3-0.5-0.3-0.5-0.5-0.2-0.0-0.00.3
Condit. Reinf. active minus inactive responses0.20.30.5-0.4-0.3-0.5-0.6-0.3-0.7-0.3-0.5-0.6-0.6-0.6-0.7
Condit. Reinf. active-inactive response ratio0.00.00.10.10.1-0.0-0.2-0.1-0.20.1-0.2-0.1-0.1-0.3-0.2
Condit. Reinf. active responses0.20.30.9-0.5-0.2-0.4-0.5-0.1-0.7-0.1-0.4-0.3-0.5-0.7-1.0
Condit. Reinf. inactive responses0.10.10.8-0.50.1-0.1-0.20.2-0.40.20.10.1-0.3-0.5-0.9
Incentive salience index mean0.70.81.5-0.9-0.6-0.8-1.0-0.4-1.1-0.5-0.7-0.9-1.1-1.1-1.2
Condit. Reinf. lever presses0.91.32.1-1.4-0.9-1.1-1.3-0.8-1.3-0.8-0.8-0.9-1.2-1.4-1.4
Condit. Reinf. active minus inactive responses0.10.10.3-0.20.20.1-0.1-0.1-0.20.10.10.40.2-0.5-0.6
Condit. Reinf. active-inactive response ratio0.30.31.00.00.80.50.30.50.20.80.71.00.5-0.2-0.7
Condit. Reinf. active responses0.30.51.3-0.7-0.4-0.5-0.8-0.6-0.8-0.5-0.5-0.3-0.5-1.1-1.0
Condit. Reinf. inactive responses0.60.71.1-0.7-0.8-0.8-1.0-0.7-0.9-0.9-0.8-1.1-0.9-1.0-0.6
Condit. Reinf. lever presses2.73.75.0-2.2-1.9-1.9-2.1-2.1-2.2-1.8-2.0-1.5-1.7-2.1-1.6
Condit. Reinf. lever reinforcers received0.60.81.8-1.0-0.7-0.8-1.0-0.9-1.0-0.8-0.8-0.6-0.7-1.3-1.0
Conditioned reinforcement - actives0.00.10.4-0.3-0.0-0.10.1-0.6-0.00.1-0.10.60.3-0.30.1
Conditioned reinforcement - inactives2.33.46.61.82.02.01.91.51.81.91.92.62.31.10.8
Conditioned locomotion7.810.114.33.33.33.43.32.93.33.33.33.83.62.41.7
Patch foraging indifference point 0 sec0.00.00.10.10.00.1-0.00.10.1-0.10.20.10.0-0.1-0.2
Patch foraging indifference point AUC2.13.04.9-1.7-2.0-1.8-1.8-2.2-1.8-1.8-2.0-1.4-1.4-1.5-0.8
Delay disc. indifference point, 0s delay0.40.40.90.30.90.30.10.90.61.00.90.0-0.20.0-0.9
Delay disc. indifference point, 16s delay0.40.40.70.50.80.70.40.80.20.80.80.80.60.0-0.8
Delay disc. indifference point, 2s delay0.10.10.20.10.40.20.10.40.10.50.40.20.0-0.1-0.4
Delay disc. indifference point, 24s delay0.20.20.40.60.30.40.50.40.50.30.30.10.30.60.6
Delay disc. indifference point, 4s delay0.10.10.40.30.30.20.20.60.30.50.5-0.2-0.20.2-0.2
Delay disc. indifference point, 8s delay0.10.10.20.10.20.10.10.40.30.30.4-0.3-0.30.1-0.2
Indifference point function ln k6.711.716.33.63.63.63.74.03.63.53.73.03.03.22.0
Indifference point function log k6.711.716.33.63.63.63.74.03.63.53.73.03.03.22.0
Patch foraging total patch changes 0 sec0.00.00.20.3-0.00.10.10.10.2-0.20.1-0.00.10.30.4
Patch foraging total patch changes 12 sec5.16.68.0-2.6-2.8-2.7-2.8-2.6-2.8-2.6-2.8-2.5-2.5-2.4-1.6
Patch foraging total patch changes 18 sec0.71.11.6-1.1-0.9-1.1-1.2-1.0-1.3-0.9-1.1-0.9-1.0-1.1-0.9
Patch foraging total patch changes 24 sec1.22.13.2-1.3-1.8-1.6-1.4-1.8-1.3-1.8-1.7-1.5-1.3-0.80.0
Patch foraging total patch changes 6 sec1.11.72.6-1.1-1.5-1.3-1.3-1.1-1.5-1.5-1.6-1.5-1.3-0.9-0.5
Patch foraging time to switch 0 sec2.65.38.9-2.7-1.7-2.2-2.5-1.7-2.5-1.7-1.6-1.9-2.4-2.9-3.0
Patch foraging water rate 0 sec4.79.812.23.52.73.23.32.63.52.72.73.03.43.53.3
Patch foraging water rate 12 sec9.319.424.54.94.04.54.94.14.93.93.93.94.45.04.4
Patch foraging water rate 18 sec3.85.88.22.72.32.42.72.52.52.21.92.02.22.92.4
Patch foraging water rate 24 sec6.28.711.63.12.83.03.22.73.42.72.82.62.93.32.8
Patch foraging water rate 6 sec6.79.814.63.52.63.13.53.03.52.72.52.53.03.83.5
Seeking ratio, delayed vs. immediate footshock0.10.10.7-0.10.10.2-0.10.4-0.10.20.40.1-0.0-0.4-0.8
Distance traveled before self-admin1.11.42.8-1.5-0.9-1.1-1.3-1.1-1.2-0.9-0.8-0.8-1.1-1.7-1.5
Distance traveled after self-admin0.30.30.7-0.6-0.7-0.5-0.7-0.7-0.6-0.6-0.5-0.4-0.4-0.8-0.4
Extensor digitorum longus weight7.931.136.8-5.9-6.0-6.1-5.8-5.7-5.8-5.8-5.9-5.9-5.9-4.5-2.9
Bone: elastic displacement2.12.45.21.80.71.51.81.21.71.10.91.11.52.32.3
Bone: elastic work0.60.82.0-0.4-1.4-0.8-0.4-0.7-0.6-1.1-1.2-1.2-0.70.40.9
Bone: endosteal estimation0.40.82.00.01.30.60.41.20.41.11.40.70.1-0.4-1.4
Bone: endosteal perimeter0.51.12.5-0.01.50.70.41.20.41.41.51.10.3-0.6-1.6
Epididymis fat weight2.79.313.62.63.53.23.13.13.23.63.73.63.11.90.8
Delta time in closed arm before/after self-admin0.20.20.60.2-0.3-0.2-0.00.20.0-0.3-0.3-0.8-0.50.60.6
Delta time in open arm before/after self-admin0.30.30.9-0.8-0.5-0.5-0.6-0.9-0.4-0.5-0.30.0-0.1-0.9-0.5
Diff in mean of infusions in LGA sessions0.40.50.9-0.6-0.9-0.7-0.6-0.8-0.8-0.9-1.0-0.7-0.6-0.40.1
Delay discount exponential model param0.10.10.40.1-0.10.10.1-0.20.1-0.2-0.20.30.40.30.6
Extinction: sum of active levers before priming3.64.05.3-2.1-1.9-2.0-2.2-1.8-2.3-1.8-1.9-1.9-2.0-2.1-1.8
Active lever presses in extinction session 63.33.34.9-2.2-1.9-2.0-1.9-2.2-1.8-1.8-1.8-1.6-1.7-1.6-0.9
Bone: final force2.84.45.4-2.3-2.1-2.3-2.2-2.2-2.2-2.3-2.2-2.1-2.2-1.8-1.2
Bone: final moment2.54.04.9-2.2-2.0-2.2-2.1-2.0-2.1-2.2-2.1-2.0-2.1-1.7-1.1
Food consumed during 24 hour testing period0.10.10.30.0-0.10.00.1-0.50.1-0.1-0.20.30.40.30.5
Glucose1.52.45.01.22.11.51.32.21.32.12.11.40.90.5-0.6
Heart weight0.61.03.30.61.30.80.71.80.71.51.30.3-0.10.3-1.0
Delay discount hyperbolic model param0.10.10.50.1-0.10.10.1-0.20.1-0.2-0.20.30.40.30.7
Intermittent access intake day 1-15 change0.91.83.41.31.41.41.30.91.31.31.31.91.71.00.8
Intermittent access intake escalation0.71.53.11.21.21.31.20.71.21.11.21.81.60.90.8
Intermittent access intake escalation 21.21.32.71.11.21.21.10.71.21.01.21.71.50.80.7
Intermitt. access day 1 inactive lever presses0.00.20.40.60.50.50.40.30.30.40.40.60.60.20.2
Intermitt. access day 15 inactive lever presses0.81.63.51.11.61.41.31.20.91.61.21.91.50.50.0
Intermitt. access escalation Index2.43.45.01.82.22.01.72.21.92.22.11.81.71.30.5
Intermittent access day 1 total infusions1.21.94.10.72.01.31.01.80.82.01.71.60.9-0.1-1.2
Intermittent access day 15 total infusions3.65.49.82.02.82.52.32.32.02.92.43.12.51.20.4
Intermittent access terminal intake (last 3 days)3.03.97.71.52.52.11.92.01.62.62.22.82.00.8-0.1
Intermittent access total infusions2.22.65.31.12.21.71.51.81.12.31.72.21.50.4-0.5
Intermittent access day 1 locomotion1.21.53.20.81.71.20.91.60.81.81.41.50.90.2-0.7
Intermittent access day 15 total locomotion2.13.88.11.62.42.11.91.91.52.42.12.92.20.6-0.1
Intermittent access total locomotion4.15.09.81.62.92.42.02.41.73.02.63.12.20.5-0.7
Intermittent access standard deviation1.02.23.21.61.61.51.61.21.51.51.31.81.71.21.0
Left kidney weight0.52.14.41.02.01.51.21.71.42.02.11.61.10.4-0.5
Right kidney weight0.31.42.41.01.31.21.21.11.41.41.61.41.10.90.5
Cocaine induced anxiety0.10.10.2-0.4-0.3-0.3-0.3-0.4-0.3-0.2-0.1-0.0-0.1-0.5-0.3
Post-drug Anxiety0.90.91.6-1.2-1.2-1.0-0.9-1.1-1.0-1.0-0.9-0.8-0.8-0.8-0.5
Baseline Anxiety0.20.30.6-0.3-0.7-0.5-0.4-0.4-0.3-0.7-0.7-0.8-0.50.20.4
Tail length0.20.81.6-0.3-1.0-0.9-0.7-1.1-0.5-1.0-1.3-1.2-0.70.31.0
Length with tail1.46.09.3-2.2-2.9-2.7-2.3-2.8-2.2-2.9-3.1-2.9-2.4-0.90.2
Length without tail1.44.67.6-1.9-2.7-2.4-1.8-2.4-1.8-2.8-2.7-2.6-2.1-0.50.6
Times rat made contact with spout0.40.50.8-0.5-0.6-0.7-0.7-0.6-0.8-0.6-0.8-0.9-0.7-0.6-0.5
Lifetime Intake1.51.93.91.01.91.41.31.70.92.01.41.71.20.4-0.4
Liver weight, left1.11.82.41.31.41.31.41.41.51.31.31.11.11.61.1
Liver weight, right2.64.66.32.32.22.12.32.52.32.12.11.71.72.41.7
Locomotor activity3.14.87.92.61.72.22.52.22.31.81.51.82.12.82.4
Locomotor testing distance3.66.410.63.01.92.52.92.52.82.21.81.92.43.32.8
Locomotor testing rearing2.75.47.52.72.02.42.72.42.52.21.81.82.12.62.4
Locomotion in novel chamber4.76.07.92.32.82.62.52.52.52.72.82.82.51.91.0
Locomotion in novel chamber post-restriction2.23.65.61.82.22.11.91.91.82.22.12.42.11.20.4
Fecal boli incidents, locomotor time 10.10.20.5-0.5-0.1-0.2-0.3-0.6-0.4-0.0-0.20.30.1-0.7-0.7
Change in fecal boli incidents, locomotor task0.10.10.20.10.0-0.00.10.50.2-0.10.2-0.4-0.40.40.1
Time >=10cm from walls, locomotor time 10.50.52.5-0.40.70.2-0.10.50.10.80.90.70.0-0.9-1.6
Bouts of movement, locomotor time 11.31.52.9-1.2-1.5-1.2-1.3-1.7-1.0-1.4-1.2-1.0-0.8-1.3-0.4
Total resting periods, locomotor time 11.01.12.2-1.1-1.2-1.0-1.2-1.5-0.9-1.2-1.0-0.7-0.6-1.3-0.6
Rest time, locomotor task time 11.41.82.51.31.41.41.41.11.41.41.31.61.51.10.9
Distance moved, locomotor task time 10.30.41.1-0.7-0.3-0.6-0.7-0.1-0.7-0.4-0.4-0.7-0.8-0.7-1.0
Vertical activity count, locomotor time 10.41.01.41.11.11.11.01.20.91.01.01.01.00.90.5
Time >=10cm from walls, locomotor time 20.10.20.8-0.6-0.1-0.4-0.5-0.6-0.1-0.10.1-0.0-0.2-0.9-0.7
Bouts of movement, locomotor time 20.40.60.9-0.7-0.8-0.7-0.9-0.9-0.8-0.9-0.7-0.7-0.6-1.0-0.7
Total resting periods, locomotor time 20.20.40.8-0.6-0.5-0.5-0.7-0.6-0.6-0.6-0.4-0.4-0.4-0.9-0.8
Rest time, locomotor task time 21.92.53.61.41.91.71.61.71.61.81.81.71.41.10.4
Distance moved, locomotor task time 20.91.11.7-1.0-1.2-1.1-1.1-1.2-1.0-1.2-1.3-1.2-1.0-0.6-0.0
Vertical activity count, locomotor time 20.40.63.00.8-0.10.40.60.20.60.0-0.00.20.61.31.7
Light reinforcement 10.10.20.50.70.30.50.50.30.50.40.20.40.60.60.7
Light reinforcement 20.50.82.00.60.90.90.90.50.91.10.91.41.10.50.2
Bone: marrow area0.40.92.30.11.30.60.41.30.51.11.50.70.1-0.4-1.4
Bone: maximum diameter0.20.41.1-1.0-0.6-0.7-0.7-0.9-0.7-0.6-0.4-0.2-0.5-0.7-0.6
Bone: maximum force4.68.111.0-3.3-2.6-3.0-3.0-2.6-3.2-2.6-2.7-2.6-3.0-3.0-2.4
Bone: maximum moment4.27.39.9-3.1-2.5-2.9-2.9-2.5-3.0-2.5-2.5-2.5-2.9-2.8-2.3
Mean time between licks in bursts0.10.30.80.1-0.6-0.3-0.1-0.1-0.1-0.6-0.6-0.8-0.40.60.9
Mean num. licks in bursts0.20.30.60.80.70.60.70.70.60.50.60.30.40.50.4
Cd content in liver0.91.02.40.81.21.10.90.80.81.11.11.51.30.3-0.1
Co content in liver2.83.35.02.21.41.81.91.52.11.31.41.31.82.22.2
Cu content in liver0.10.10.8-0.2-0.0-0.1-0.20.1-0.50.1-0.1-0.1-0.1-0.7-0.9
Fe content in liver0.10.10.3-0.2-0.5-0.3-0.1-0.3-0.1-0.4-0.5-0.3-0.20.40.5
K content in liver0.70.71.2-0.9-0.7-0.9-0.8-0.4-0.9-0.7-0.7-1.0-1.1-0.7-0.9
Mg content in liver0.20.20.80.50.60.50.50.90.40.60.60.20.20.3-0.2
Mn content in liver3.64.05.1-2.2-2.2-2.1-2.0-2.3-2.1-2.1-2.2-1.8-1.8-1.6-1.0
Na content in liver0.20.30.6-0.4-0.7-0.5-0.3-0.8-0.2-0.7-0.6-0.4-0.30.10.5
Rb content in liver1.82.13.41.61.61.61.61.91.41.61.51.21.31.20.5
Se content in liver0.10.10.4-0.00.20.30.20.10.00.40.20.60.4-0.2-0.2
Sr content in liver2.01.73.2-1.2-1.6-1.4-1.3-1.8-1.1-1.6-1.6-1.2-1.0-0.80.1
Zn content in liver0.30.30.5-0.5-0.5-0.6-0.6-0.4-0.6-0.5-0.5-0.7-0.6-0.7-0.5
Bone: minimum diameter0.40.83.2-0.21.00.40.11.1-0.11.01.10.5-0.1-1.0-1.8
Time in familiar zone, hab. session 10.10.10.30.20.60.30.20.60.10.50.30.30.2-0.1-0.5
Time in novel zone, hab. session 10.80.82.31.00.40.70.90.61.10.40.60.40.71.41.5
Total zone transitions, hab. session 10.91.31.9-1.1-1.0-1.1-1.2-1.0-1.4-1.0-1.1-1.0-1.1-1.3-1.2
Total locomotion distance, hab. session 10.20.20.60.10.70.30.10.60.20.60.80.30.0-0.2-0.8
Locomotion velocity, hab. session 10.10.10.8-0.30.2-0.2-0.30.1-0.30.10.2-0.1-0.4-0.6-0.9
Time in familiar zone, hab. session 20.40.41.60.70.10.30.60.40.6-0.00.0-0.10.31.21.3
Time in novel zone, hab. session 20.40.41.3-0.7-0.3-0.4-0.6-0.4-0.6-0.2-0.1-0.3-0.5-1.1-1.2
Total zone transitions, hab. session 22.63.45.1-2.0-1.3-1.8-2.0-1.1-2.0-1.3-1.3-1.9-2.2-2.2-2.3
Total locomotion distance, hab. session 20.40.52.2-0.60.2-0.4-0.60.3-0.60.10.2-0.6-0.9-0.9-1.5
Locomotion velocity, hab. session 20.40.52.5-0.60.3-0.3-0.50.4-0.50.30.4-0.4-0.8-1.0-1.6
Novel to familiar place preference ratio1.71.83.4-1.6-1.1-1.3-1.5-1.5-1.5-1.1-1.1-0.8-1.1-1.8-1.5
Novelty place preference0.91.02.3-1.2-0.7-0.9-1.1-1.1-1.1-0.7-0.7-0.4-0.7-1.5-1.3
Time in novel zone, NPP test0.60.71.6-1.0-0.6-0.7-1.0-0.9-0.9-0.6-0.6-0.4-0.6-1.3-1.1
Total zone transitions, NPP test3.04.35.3-2.3-1.9-2.2-2.3-1.8-2.2-1.9-1.8-2.1-2.3-2.1-1.8
Total locomotion distance, NPP test0.30.41.2-0.7-0.2-0.5-0.7-0.0-0.6-0.2-0.1-0.7-0.9-0.8-1.1
Locomotion velocity, NPP test0.40.51.5-0.8-0.3-0.6-0.8-0.2-0.7-0.3-0.2-0.7-0.9-1.0-1.2
Intraocular pressure1.31.93.61.41.31.41.40.71.51.21.41.91.81.01.0
Delta distance traveled before/after self-admin0.50.51.71.00.20.70.80.60.60.30.30.30.71.11.3
Delta ambulatory time before/after self-admin0.30.31.40.80.00.40.50.40.40.10.00.10.41.01.2
Parametrial fat weight2.66.111.32.13.02.62.22.82.53.03.42.82.21.2-0.1
Pavlov. Cond. lever latency0.50.60.90.90.70.80.90.50.80.50.50.80.90.90.9
Pavlov. Cond. magazine entry latency0.91.13.1-1.2-0.4-0.9-1.2-0.6-1.1-0.5-0.4-0.8-1.1-1.6-1.8
Pavlov. Cond. change in total contacts0.70.72.5-1.0-0.3-0.6-0.9-0.6-0.9-0.3-0.3-0.2-0.5-1.6-1.5
Pavlov. Cond. index score0.40.51.0-0.9-0.5-0.7-0.8-0.7-0.8-0.5-0.4-0.5-0.6-1.0-0.9
Pavlov. Cond. latency score0.30.40.8-0.8-0.4-0.6-0.7-0.5-0.6-0.3-0.3-0.5-0.7-0.9-0.9
Pavlov. Cond. lever contacts0.30.30.6-0.7-0.4-0.5-0.6-0.2-0.6-0.3-0.2-0.6-0.7-0.8-0.8
Pavlov. Cond. magazine entry number0.40.61.00.80.60.70.90.90.80.60.60.40.51.00.8
Pavlov. Cond. intertrial magazine entries0.50.61.40.80.60.90.90.60.60.80.41.11.20.60.6
Pavlov. Cond. lever-magazine prob. diff.0.70.91.8-1.1-0.7-0.9-1.1-0.9-1.0-0.7-0.6-0.7-0.9-1.3-1.2
Pavlov. Cond. response bias0.30.40.8-0.8-0.6-0.6-0.8-0.7-0.7-0.5-0.5-0.4-0.5-0.9-0.7
Pavlov. Cond. lever latency0.71.01.51.21.01.01.11.21.10.91.00.60.81.00.7
Pavlov. Cond. magazine entry latency5.76.88.5-2.8-2.6-2.7-2.8-2.6-2.9-2.4-2.7-2.4-2.5-2.7-2.1
Pavlov. Cond. change in total contacts2.54.06.1-2.3-1.8-1.9-2.2-2.1-2.3-1.6-1.8-1.2-1.6-2.5-2.2
Pavlov. Cond. index score3.54.76.1-2.5-2.1-2.2-2.4-2.3-2.5-1.9-2.2-1.7-2.0-2.4-2.0
Pavlov. Cond. latency score3.14.15.5-2.3-1.9-2.0-2.2-2.1-2.3-1.7-2.0-1.6-1.8-2.2-1.9
Pavlov. Cond. lever contacts0.71.01.6-1.2-1.0-1.0-1.1-1.3-1.1-0.9-1.1-0.6-0.8-1.0-0.8
Pavlov. Cond. magazine entry number8.610.712.93.53.33.43.53.53.63.23.43.03.03.32.4
Pavlov. Cond. intertrial magazine entries1.01.51.91.21.41.31.21.21.31.21.41.31.31.10.7
Pavlov. Cond. lever-magazine prob. diff.4.25.57.1-2.6-2.3-2.4-2.6-2.5-2.7-2.1-2.4-1.9-2.1-2.5-2.0
Pavlov. Cond. response bias2.73.74.7-2.2-1.8-2.0-2.1-2.1-2.1-1.7-2.0-1.6-1.8-2.0-1.6
Time in closed arm before self-admin0.10.20.4-0.10.40.30.10.20.30.50.70.70.3-0.3-0.7
Time in closed arm after self-admin0.20.20.60.50.30.50.40.70.50.40.60.40.40.50.2
Time in open arm before self-admin0.80.82.21.30.70.70.91.10.80.60.3-0.10.41.51.3
Time in open arm after self-admin0.00.00.20.1-0.2-0.10.0-0.20.2-0.1-0.1-0.3-0.10.20.4
Bone: periosteal estimation0.20.41.5-0.9-0.1-0.5-0.5-0.2-0.6-0.10.0-0.1-0.6-0.9-1.2
Bone: periosteal perimeter0.40.71.4-1.1-0.5-0.8-0.8-0.6-0.9-0.4-0.4-0.5-0.8-1.1-1.2
Bone: post-yield work4.26.220.6-3.0-0.7-2.0-2.6-1.0-2.8-0.9-0.9-1.4-2.5-3.9-4.5
Progressive ratio test 1 active lever presses0.20.20.60.30.70.40.40.30.20.70.30.70.5-0.0-0.1
Progressive ratio test 1 breakpoint0.10.20.50.30.70.40.40.20.20.60.20.70.4-0.1-0.1
Progressive ratio test 1 inactive lever presses0.10.10.20.40.40.30.30.10.20.30.20.50.4-0.10.0
Progressive ratio test 2 active lever presses1.82.14.31.21.91.51.41.31.21.81.42.11.60.60.2
Progressive ratio test 2 breakpoint1.82.14.41.31.91.51.51.31.21.81.42.11.70.60.3
Progressive ratio test 2 inactive lever presses5.18.213.62.63.33.12.92.82.73.43.23.73.11.50.6
Incentive Sensitization - Responses0.10.10.6-0.50.1-0.2-0.3-0.1-0.50.1-0.10.1-0.2-0.6-0.8
Incentive Sensitization - Breakpoint0.10.10.5-0.20.30.0-0.10.1-0.30.30.10.40.0-0.5-0.7
Sum of active levers in priming session hrs 5-60.90.93.2-0.9-1.2-0.8-0.7-1.8-0.8-1.2-1.3-0.00.0-0.40.6
Progressive ratio2.13.37.3-2.2-1.1-1.8-1.9-1.1-1.8-1.1-1.0-1.6-2.1-2.3-2.7
Food seeking constrained by brief footshock0.10.10.2-0.0-0.4-0.2-0.1-0.1-0.3-0.4-0.4-0.3-0.20.20.2
Seeking ratio, punishment vs. effort2.63.86.92.41.31.92.11.71.91.31.21.52.02.52.6
Retroperitoneal fat weight8.938.147.56.26.86.66.46.86.46.96.96.35.95.02.7
Reaction time number correct0.10.20.6-0.2-0.5-0.4-0.2-0.6-0.2-0.5-0.7-0.4-0.20.40.8
Reaction time mean minus median2.35.67.8-2.8-2.4-2.5-2.5-2.7-2.4-2.3-2.1-2.0-2.2-2.6-1.9
Reaction time mean minus median AUC0.92.43.8-1.8-1.7-1.7-1.5-2.0-1.5-1.6-1.6-1.3-1.4-1.4-0.8
Reaction time num false alarms0.60.92.11.30.60.90.91.21.00.60.50.30.61.51.3
Reaction time num false alarms AUC0.10.20.80.6-0.10.20.30.50.3-0.1-0.1-0.30.00.90.9
Reaction time trials correct on left0.10.20.6-0.2-0.5-0.4-0.2-0.6-0.2-0.5-0.7-0.4-0.20.40.8
Reaction time trials on left0.20.30.7-0.2-0.6-0.5-0.3-0.7-0.3-0.6-0.8-0.5-0.30.40.8
Reaction time mean0.10.20.6-0.6-0.3-0.4-0.6-0.6-0.3-0.30.0-0.0-0.2-0.8-0.8
Reaction time mean AUC0.20.31.0-0.6-0.2-0.3-0.6-0.6-0.3-0.30.10.0-0.2-0.9-1.0
Median of all reaction times0.10.10.40.00.40.2-0.10.00.30.30.60.50.3-0.3-0.6
Reaction time omissions1.92.73.6-1.9-1.9-1.8-1.7-1.9-1.6-1.6-1.6-1.6-1.6-1.6-1.0
Reaction time false alarm rate0.30.41.10.90.40.70.61.00.70.50.50.20.40.90.6
Reaction time premature initiation rate1.72.34.9-1.2-1.9-1.7-1.3-1.5-1.2-1.8-1.9-2.2-1.7-0.40.4
Reaction time premature initiations2.03.66.4-1.4-2.3-2.1-1.6-2.1-1.5-2.3-2.5-2.5-1.9-0.30.7
Std. dev. reaction times0.91.72.6-1.6-1.4-1.4-1.4-1.6-1.2-1.3-0.9-0.9-1.1-1.5-1.1
Reaction time trials completed0.20.30.7-0.2-0.6-0.5-0.3-0.7-0.3-0.6-0.8-0.5-0.30.40.8
Reaction time trials AUC0.10.20.7-0.1-0.4-0.3-0.1-0.5-0.1-0.4-0.6-0.4-0.20.50.8
Run reversals in cocaine runway, females0.70.71.6-0.7-0.5-0.8-0.90.0-0.9-0.5-0.5-1.2-1.3-0.7-1.1
Run reversals in cocaine runway, males1.21.23.21.20.61.01.20.61.10.50.50.91.21.51.8
Latency to leave start box in cocaine runway0.20.21.3-0.40.1-0.1-0.30.3-0.40.20.1-0.0-0.3-0.7-1.2
Latency to leave start box in cocaine runway, F0.10.20.9-0.30.2-0.1-0.20.2-0.30.20.1-0.0-0.2-0.7-1.0
Latency to leave start box in cocaine runway, M0.20.10.4-0.5-0.4-0.3-0.3-0.0-0.6-0.2-0.3-0.2-0.4-0.3-0.5
Std. dev. time between licks in bursts0.30.51.90.80.10.40.70.60.80.10.2-0.10.21.21.4
Total sessions with >9 infusions0.20.21.0-0.60.1-0.3-0.40.1-0.60.2-0.2-0.2-0.5-0.7-1.0
Short access day 1 total inactive lever presses1.82.43.51.71.71.71.61.91.41.71.61.71.51.30.5
Short access day 10 total inactive lever presses0.30.81.61.30.90.90.91.00.70.80.60.70.81.00.6
Short access day 1 total infusions0.91.22.40.81.41.10.91.50.81.51.31.10.70.3-0.5
Short access day 10 total infusions0.40.63.3-0.40.80.0-0.20.7-0.70.80.20.3-0.3-1.0-1.8
Short access total infusions0.20.31.0-0.00.80.30.10.8-0.20.90.30.4-0.1-0.3-1.0
Short access day 1 locomotion1.01.22.31.11.41.21.11.40.71.51.01.31.00.5-0.1
Short access day 10 total locomotion0.40.71.60.51.30.80.61.00.41.20.91.10.6-0.2-0.8
Short access total locomotion0.81.02.20.71.41.00.81.20.51.51.01.30.80.1-0.6
One hour access (0.3 mA shock)6.37.39.82.73.12.92.82.82.63.02.83.12.82.01.0
Compulsive drug intake1.01.23.0-0.5-1.4-1.0-0.8-1.0-0.6-1.6-1.3-1.7-1.10.30.9
One hour access (shock baseline)4.87.312.62.43.22.92.72.72.53.32.93.52.91.40.4
Social response proportion0.70.81.3-1.0-1.0-0.9-1.0-1.1-0.9-1.1-0.8-0.7-0.8-0.9-0.6
Social responses0.10.20.4-0.2-0.6-0.4-0.2-0.5-0.3-0.6-0.6-0.4-0.20.10.4
Social time0.20.20.5-0.2-0.6-0.5-0.2-0.6-0.3-0.6-0.7-0.6-0.40.30.6
Soleus weight4.112.114.93.53.83.73.63.83.63.93.83.63.42.91.5
Bone: stiffness3.75.98.2-2.9-2.1-2.5-2.7-2.3-2.7-2.2-2.1-2.1-2.5-2.8-2.3
Tibialis anterior weight9.130.743.0-5.7-6.6-6.1-5.5-6.4-5.4-6.3-6.4-5.7-5.3-3.6-1.3
Time to tail flick, vehicle, before self-admin0.40.40.9-0.8-0.3-0.7-0.7-0.5-0.5-0.3-0.3-0.6-0.8-0.8-0.9
Time to tail flick, vehicle, after self-admin1.01.32.9-1.3-0.5-1.2-1.2-0.4-1.1-0.6-0.5-1.4-1.7-1.3-1.7
Time to tail flick, test, before self-admin1.31.33.41.01.61.21.01.80.81.51.20.90.60.6-0.5
Time to tail flick, test, after self-admin0.00.00.2-0.3-0.1-0.2-0.2-0.4-0.0-0.2-0.10.0-0.1-0.10.0
Delta time to tail flick, vehicle, before/after SA0.50.51.0-0.7-0.5-0.7-0.7-0.3-0.8-0.6-0.5-0.9-1.0-0.6-0.8
Delta time to tail flick, test, before/after SA1.01.13.8-0.8-1.4-1.0-0.7-1.9-0.4-1.4-1.1-0.6-0.2-0.21.1
Tibia length1.13.05.9-2.1-1.8-1.8-1.8-2.4-1.8-1.8-1.9-0.9-1.1-1.6-1.0
Ambulatory time before self-admin0.81.22.7-1.4-0.7-1.0-1.2-1.1-1.2-0.8-0.7-0.5-0.9-1.6-1.5
Ambulatory time after self-admin0.10.10.50.00.30.3-0.10.2-0.10.30.40.50.3-0.6-0.7
Bone: tissue strength0.00.00.1-0.20.0-0.1-0.2-0.1-0.2-0.1-0.1-0.0-0.1-0.4-0.4
Total heroin consumption5.46.37.7-2.6-2.7-2.7-2.7-2.8-2.6-2.7-2.7-2.5-2.4-2.2-1.3
Bone: trabecular number1.62.64.6-1.9-1.2-1.5-1.7-1.3-1.9-1.2-1.3-1.2-1.6-2.1-2.0
Bone: trabecular spacing0.71.01.61.30.91.01.01.01.10.90.80.60.81.20.9
Bone: trabecular thickness0.20.20.60.10.50.40.20.60.00.50.50.40.2-0.4-0.8
Bone: trabecular tissue density4.36.47.92.62.72.72.62.42.62.62.62.82.72.11.3
Water consumed over 24 hours0.70.91.6-0.8-1.1-1.0-0.9-1.2-1.0-1.1-1.3-1.1-0.8-0.6-0.2
Number of responses in last shaping day0.10.10.40.50.10.20.30.20.40.10.10.00.20.50.6