Hub : Genes

LOC120097018

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC120097018	0.05	0.03	3.1e-05	0.06	0.03	0.03	0.05	1.0e-06	8.2e-04	1.8e-04	4.7e-06
2	NAcc	gene expression	LOC120097018	0.02	0.02	5.1e-03	0	0.02	0	-0	3.3e-01	4.0e-03	1.2e-01	5.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.8	1.4	1.5	1.2	-1.1
Area under the delay curve	7.1	7.5	8.0	-2.8	2.6
BMI with tail	1.1	3.5	4.0	-1.7	2.0
BMI without tail	0.1	0.2	0.3	0.6	-0.4
Body weight	1.3	5.3	6.6	-2.6	2.0
Weight adjusted by age	0.6	0.7	1.1	-1.0	0.6
Bone surface	0.3	0.5	0.6	0.8	-0.7
Bone volume	0.1	0.2	0.3	0.5	-0.3
Breakpoint value in progressive ratio session	0.6	0.6	0.8	-0.9	0.7
Number of licking bursts	0.3	0.3	0.3	-0.6	0.6
Context. condit. distance diff. score	1.4	1.6	2.5	1.6	-0.9
Locomotion velocity, session 1	0.1	0.1	0.2	-0.2	0.4
Locomotion distance, session 1	0.1	0.1	0.1	0.3	0.3
Locomotion velocity, session 2	0.3	0.4	0.5	-0.5	0.7
Locomotion distance, session 2	0.0	0.1	0.1	0.4	-0.1
Locomotion velocity, session 3	0.8	0.9	1.4	-1.2	0.7
Locomotion distance, session 3	1.0	1.1	1.7	-1.3	0.7
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	-0.1	-0.6
Stereotopy head waving duration, day 3	0.7	0.8	1.3	-1.2	0.6
Locomotion velocity, session 7	1.5	1.6	1.7	1.3	-1.2
Locomotion distance, session 7	3.0	3.9	4.8	2.2	-1.7
Stereotopy head waving bouts, day 7	2.4	2.6	3.9	-2.0	1.2
Stereotopy head waving duration, day 7	3.2	3.9	5.9	-2.4	1.4
Locomotion velocity, session 8	0.1	0.1	0.2	-0.1	0.5
Locomotion distance, session 8	0.5	0.8	1.4	1.2	-0.4
Degree of sensitization distance	7.6	7.6	10.1	3.2	-2.3
Degree of sensitization stereotypy	2.5	2.8	3.8	-1.9	1.3
Conditioned locomotion	0.2	0.2	0.4	0.3	-0.6
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.3	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.2	0.3
Cocaine response before conditioning	0.0	0.0	0.0	0.0	0.0
Saline control response	0.0	0.0	0.0	-0.0	0.0
Bone: connectivity density	3.1	4.9	6.3	1.9	-2.5
Bone: cortical apparent density	0.2	0.2	0.3	-0.6	0.4
Bone: cortical area	1.7	2.6	3.2	-1.4	1.8
Bone: cortical porosity	2.4	2.7	3.4	-1.8	1.4
Bone: cortical porosity	2.0	2.2	2.6	-1.6	1.3
Bone: cortical thickness	2.8	4.6	5.1	-2.0	2.3
Bone: cortical thickness	2.1	2.5	3.8	-1.1	2.0
Bone: cortical tissue density	0.2	0.2	0.3	-0.5	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.6	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	-0.2
Condit. Reinf. active responses	0.2	0.2	0.2	-0.5	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.1
Incentive salience index mean	1.3	1.6	1.9	-1.4	1.2
Condit. Reinf. lever presses	1.7	2.3	2.4	-1.5	1.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	0.0
Condit. Reinf. active responses	0.2	0.3	0.4	0.6	-0.3
Condit. Reinf. inactive responses	1.7	2.1	3.1	1.7	-1.1
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.3	-0.1
Conditioned reinforcement - actives	5.9	5.9	6.5	2.6	-2.3
Conditioned reinforcement - inactives	3.0	3.4	3.4	1.8	-1.9
Conditioned locomotion	1.1	1.4	2.1	1.4	-0.8
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.2	-0.2
Patch foraging indifference point AUC	0.3	0.4	0.8	0.1	0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.2	-0.0
Delay disc. indifference point, 16s delay	4.4	4.4	5.1	-1.9	2.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.2	-1.1	0.9
Delay disc. indifference point, 24s delay	5.2	5.0	5.4	-2.2	2.3
Delay disc. indifference point, 4s delay	4.6	4.9	5.1	-2.3	2.2
Delay disc. indifference point, 8s delay	9.2	9.5	11.8	-3.4	2.7
Indifference point function ln k	0.2	0.3	0.6	-0.8	0.2
Indifference point function log k	0.2	0.3	0.6	-0.8	0.2
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.1	0.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.3	0.6
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.7	-0.0
Patch foraging total patch changes 24 sec	0.2	0.2	0.2	-0.4	0.5
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.3	0.1
Patch foraging time to switch 0 sec	0.3	0.4	0.5	0.6	-0.7
Patch foraging water rate 0 sec	0.7	1.1	1.5	-0.8	1.2
Patch foraging water rate 12 sec	0.2	0.2	0.4	-0.4	0.6
Patch foraging water rate 18 sec	4.2	5.6	6.2	-2.5	2.3
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.0	0.4
Patch foraging water rate 6 sec	1.0	1.4	1.7	-1.0	1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.4	0.5	-0.7
Distance traveled before self-admin	0.0	0.0	0.0	0.2	-0.0
Distance traveled after self-admin	0.1	0.1	0.1	0.1	0.3
Extensor digitorum longus weight	7.7	30.3	31.6	-5.4	5.6
Bone: elastic displacement	0.0	0.0	0.1	0.2	-0.3
Bone: elastic work	0.6	0.7	0.8	-0.9	0.8
Bone: endosteal estimation	0.0	0.1	0.1	0.3	-0.2
Bone: endosteal perimeter	0.3	0.6	0.6	0.7	-0.8
Epididymis fat weight	0.0	0.0	0.0	0.2	-0.2
Delta time in closed arm before/after self-admin	1.2	1.2	1.5	1.2	-0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.1	-0.4
Diff in mean of infusions in LGA sessions	4.9	5.4	8.3	-2.9	1.6
Delay discount exponential model param	8.1	8.5	9.2	3.0	-2.8
Extinction: sum of active levers before priming	0.3	0.3	0.4	0.6	-0.4
Active lever presses in extinction session 6	0.6	0.6	0.9	0.9	-0.5
Bone: final force	1.5	2.4	2.5	-1.5	1.6
Bone: final moment	1.4	2.2	2.2	-1.5	1.5
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.2	0.2
Glucose	0.2	0.2	0.4	-0.3	0.6
Heart weight	0.0	0.0	0.0	-0.2	-0.2
Delay discount hyperbolic model param	8.1	8.6	9.4	3.1	-2.8
Intermittent access intake day 1-15 change	0.6	0.6	0.8	0.5	-0.9
Intermittent access intake escalation	0.5	0.5	0.5	0.6	-0.7
Intermittent access intake escalation 2	0.3	0.3	0.5	0.3	-0.7
Intermitt. access day 1 inactive lever presses	2.0	2.1	3.0	1.1	-1.7
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	0.0	-0.8
Intermitt. access escalation Index	0.3	0.3	0.4	0.7	-0.3
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.6	0.1
Intermittent access day 15 total infusions	0.9	1.0	1.4	1.2	-0.9
Intermittent access terminal intake (last 3 days)	0.5	0.5	0.8	0.9	-0.5
Intermittent access total infusions	1.0	1.1	1.7	1.3	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	-0.4
Intermittent access total locomotion	0.0	0.0	0.0	-0.2	0.0
Intermittent access standard deviation	0.3	0.4	0.6	0.7	-0.4
Left kidney weight	1.0	2.9	4.7	-2.2	1.0
Right kidney weight	0.9	2.6	4.7	-2.2	0.7
Cocaine induced anxiety	0.2	0.2	0.3	-0.6	0.3
Post-drug Anxiety	0.3	0.4	0.4	-0.7	-0.5
Baseline Anxiety	0.1	0.1	0.2	0.2	-0.5
Tail length	0.6	1.8	2.4	1.0	-1.6
Length with tail	0.2	0.7	1.5	-1.2	0.1
Length without tail	3.3	7.1	9.7	-3.1	2.1
Times rat made contact with spout	0.0	0.0	0.0	-0.1	-0.1
Lifetime Intake	1.3	1.5	2.2	1.5	-0.9
Liver weight, left	3.1	5.0	6.4	-2.5	1.9
Liver weight, right	2.3	3.8	3.9	-2.0	1.9
Locomotor activity	2.3	3.7	5.0	-2.2	1.6
Locomotor testing distance	0.1	0.1	0.2	-0.4	-0.2
Locomotor testing rearing	0.7	1.2	1.9	0.6	-1.4
Locomotion in novel chamber	0.8	0.9	1.2	-1.1	0.8
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	0.1	1.0
Fecal boli incidents, locomotor time 1	0.7	0.8	0.9	-0.8	0.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.3	-0.7
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	0.3	-0.6
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	0.3
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.1	0.7
Distance moved, locomotor task time 1	0.4	0.5	0.6	0.6	-0.8
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.0	0.2
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.4	0.5	-0.6
Bouts of movement, locomotor time 2	2.8	3.0	3.8	-1.9	1.5
Total resting periods, locomotor time 2	3.6	3.9	4.6	-2.1	1.8
Rest time, locomotor task time 2	3.0	3.4	4.9	-1.4	2.2
Distance moved, locomotor task time 2	1.1	1.3	1.3	1.1	-1.1
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.6	-0.2
Light reinforcement 1	0.2	0.3	0.4	0.6	-0.5
Light reinforcement 2	0.3	0.4	0.4	0.6	-0.6
Bone: marrow area	0.1	0.1	0.2	0.4	-0.3
Bone: maximum diameter	0.8	1.4	1.8	-1.0	1.3
Bone: maximum force	2.0	3.5	4.1	-1.7	2.0
Bone: maximum moment	1.8	3.1	3.6	-1.6	1.9
Mean time between licks in bursts	4.2	5.9	7.9	2.0	-2.8
Mean num. licks in bursts	0.3	0.3	0.4	0.5	-0.6
Cd content in liver	0.4	0.4	0.7	0.3	-0.8
Co content in liver	1.5	1.8	2.1	-1.2	1.4
Cu content in liver	0.3	0.3	0.4	-0.6	0.5
Fe content in liver	1.5	1.8	2.2	1.2	-1.5
K content in liver	0.2	0.2	0.2	0.4	-0.4
Mg content in liver	0.5	0.5	0.6	0.7	-0.8
Mn content in liver	1.1	1.2	1.4	1.2	-1.0
Na content in liver	4.4	4.7	5.1	-2.3	2.0
Rb content in liver	1.3	1.6	1.9	1.2	-1.4
Se content in liver	0.2	0.2	0.4	0.2	-0.6
Sr content in liver	2.5	2.3	2.6	1.4	-1.6
Zn content in liver	1.1	1.3	1.9	-1.4	0.8
Bone: minimum diameter	0.7	1.3	1.7	-1.0	1.3
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.5	-0.0
Time in novel zone, hab. session 1	2.0	2.0	2.7	-1.6	1.1
Total zone transitions, hab. session 1	0.6	0.9	1.5	-0.5	1.2
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.1	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.4	0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.5	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.3	0.4
Total zone transitions, hab. session 2	0.4	0.5	0.8	-0.4	0.9
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.1	0.6
Locomotion velocity, hab. session 2	0.4	0.5	0.9	-0.2	1.0
Novel to familiar place preference ratio	0.2	0.2	0.4	0.6	-0.1
Novelty place preference	0.2	0.2	0.4	0.6	-0.2
Time in novel zone, NPP test	0.1	0.1	0.2	0.5	-0.2
Total zone transitions, NPP test	0.0	0.0	0.1	0.2	0.2
Total locomotion distance, NPP test	2.0	2.8	3.8	1.9	-1.4
Locomotion velocity, NPP test	1.9	2.8	3.8	1.9	-1.3
Intraocular pressure	2.7	3.7	3.8	1.9	-1.9
Delta distance traveled before/after self-admin	0.2	0.3	0.4	-0.4	0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.2	0.7
Parametrial fat weight	2.0	3.9	4.6	2.1	-1.8
Pavlov. Cond. lever latency	0.6	0.8	0.8	0.9	-0.8
Pavlov. Cond. magazine entry latency	0.5	0.7	1.2	-1.1	0.4
Pavlov. Cond. change in total contacts	3.0	3.2	3.6	-1.7	1.9
Pavlov. Cond. index score	1.9	2.4	3.0	-1.7	1.4
Pavlov. Cond. latency score	1.4	1.8	2.3	-1.5	1.1
Pavlov. Cond. lever contacts	0.9	1.1	1.3	-1.2	0.9
Pavlov. Cond. magazine entry number	1.5	1.9	2.5	1.6	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.5	-0.0
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	3.8	-2.0	1.6
Pavlov. Cond. response bias	2.2	2.7	3.6	-1.9	1.3
Pavlov. Cond. lever latency	0.6	0.8	1.1	1.0	-0.8
Pavlov. Cond. magazine entry latency	1.2	1.4	1.5	-1.2	1.2
Pavlov. Cond. change in total contacts	2.6	3.6	4.2	-2.1	1.7
Pavlov. Cond. index score	1.6	2.1	2.4	-1.6	1.3
Pavlov. Cond. latency score	1.2	1.6	1.9	-1.4	1.1
Pavlov. Cond. lever contacts	0.4	0.5	0.6	-0.8	0.7
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.7	-0.9
Pavlov. Cond. intertrial magazine entries	9.6	12.6	13.1	3.6	-3.5
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.2	-1.5	1.4
Pavlov. Cond. response bias	1.4	1.9	2.1	-1.5	1.3
Time in closed arm before self-admin	2.2	2.5	3.3	-1.8	1.3
Time in closed arm after self-admin	0.1	0.1	0.1	-0.4	0.4
Time in open arm before self-admin	0.8	0.9	1.4	1.2	-0.6
Time in open arm after self-admin	0.7	0.8	1.0	0.7	-1.0
Bone: periosteal estimation	0.2	0.4	0.6	-0.5	0.7
Bone: periosteal perimeter	0.0	0.0	0.1	-0.1	0.3
Bone: post-yield work	0.7	1.0	1.9	-0.1	1.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.2	0.4
Progressive ratio test 1 inactive lever presses	1.1	1.2	1.3	1.0	-1.2
Progressive ratio test 2 active lever presses	1.5	1.6	1.8	1.3	-1.2
Progressive ratio test 2 breakpoint	1.0	1.1	1.1	1.0	-1.1
Progressive ratio test 2 inactive lever presses	2.0	2.3	2.4	1.5	-1.5
Incentive Sensitization - Responses	2.2	2.2	2.5	1.4	-1.6
Incentive Sensitization - Breakpoint	2.4	2.4	2.8	1.4	-1.7
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	0.9	-0.6
Progressive ratio	1.0	1.2	1.7	-1.3	0.8
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.4	-0.2
Seeking ratio, punishment vs. effort	0.3	0.4	0.6	0.8	-0.3
Retroperitoneal fat weight	0.2	0.6	0.7	0.8	-0.8
Reaction time number correct	0.5	0.7	0.8	0.8	-0.9
Reaction time mean minus median	0.7	0.9	1.6	-1.3	0.4
Reaction time mean minus median AUC	0.2	0.3	0.6	-0.7	-0.1
Reaction time num false alarms	0.2	0.3	0.4	-0.6	0.4
Reaction time num false alarms AUC	0.3	0.4	0.5	-0.7	0.6
Reaction time trials correct on left	0.5	0.7	0.8	0.8	-0.9
Reaction time trials on left	0.7	1.0	1.0	0.9	-1.0
Reaction time mean	0.2	0.2	0.3	-0.4	-0.5
Reaction time mean AUC	0.2	0.3	0.4	-0.6	-0.4
Median of all reaction times	0.3	0.3	0.7	0.0	-0.8
Reaction time omissions	2.9	4.0	4.9	1.7	-2.2
Reaction time false alarm rate	0.7	1.0	1.0	-1.0	1.0
Reaction time premature initiation rate	0.6	0.8	0.8	-0.9	0.9
Reaction time premature initiations	0.1	0.1	0.1	-0.3	0.3
Std. dev. reaction times	0.1	0.2	0.4	-0.6	-0.1
Reaction time trials completed	0.7	1.0	1.0	0.9	-1.0
Reaction time trials AUC	0.8	1.2	1.2	1.1	-1.1
Run reversals in cocaine runway, females	0.6	0.6	1.0	1.0	-0.4
Run reversals in cocaine runway, males	4.5	4.3	5.2	-1.9	2.3
Latency to leave start box in cocaine runway	1.4	1.5	2.2	1.5	-0.9
Latency to leave start box in cocaine runway, F	0.4	0.4	0.9	0.9	-0.2
Latency to leave start box in cocaine runway, M	2.0	1.9	2.5	1.1	-1.6
Std. dev. time between licks in bursts	1.6	2.0	2.9	1.0	-1.7
Total sessions with >9 infusions	1.5	1.6	2.1	1.1	-1.4
Short access day 1 total inactive lever presses	0.3	0.3	0.5	0.7	-0.3
Short access day 10 total inactive lever presses	0.8	0.9	1.0	0.9	-1.0
Short access day 1 total infusions	3.3	3.5	4.2	2.1	-1.6
Short access day 10 total infusions	0.3	0.3	0.7	-0.0	0.8
Short access total infusions	0.3	0.4	0.5	0.7	-0.5
Short access day 1 locomotion	0.1	0.1	0.3	-0.0	-0.5
Short access day 10 total locomotion	0.4	0.5	0.9	-1.0	0.1
Short access total locomotion	0.2	0.2	0.4	-0.6	-0.2
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.6	-0.2
Compulsive drug intake	0.1	0.1	0.2	-0.4	0.3
One hour access (shock baseline)	0.7	0.9	1.3	1.2	-0.6
Social response proportion	2.8	3.0	3.0	1.7	-1.7
Social responses	3.9	5.0	5.2	2.2	-2.3
Social time	0.5	0.6	0.9	0.6	-1.0
Soleus weight	0.5	1.5	1.5	-1.2	1.2
Bone: stiffness	1.0	1.6	1.7	-1.3	1.3
Tibialis anterior weight	7.3	25.0	25.2	-5.0	5.0
Time to tail flick, vehicle, before self-admin	1.2	1.2	1.3	-1.1	1.1
Time to tail flick, vehicle, after self-admin	1.9	2.0	2.1	-1.4	1.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.4	0.3
Time to tail flick, test, after self-admin	5.7	5.9	5.9	2.4	-2.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.5	-0.3
Delta time to tail flick, test, before/after SA	5.6	5.0	5.4	2.3	-2.2
Tibia length	0.1	0.3	0.7	-0.8	0.0
Ambulatory time before self-admin	0.0	0.0	0.1	-0.0	0.2
Ambulatory time after self-admin	0.7	0.8	1.1	-0.7	1.0
Bone: tissue strength	0.1	0.1	0.3	0.1	-0.5
Total heroin consumption	0.7	0.8	0.9	-0.8	1.0
Bone: trabecular number	1.3	2.0	2.3	1.3	-1.5
Bone: trabecular spacing	2.9	3.8	4.2	-1.9	2.0
Bone: trabecular thickness	0.2	0.3	0.4	-0.4	0.6
Bone: trabecular tissue density	2.1	3.0	3.1	-1.8	1.7
Water consumed over 24 hours	1.1	1.3	1.4	-1.2	1.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.3	0.3