Hub : Genes

LOC120096976

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC120096976	0.09	0.07	2.0e-09	0.05	0.06	0.04	0.05	2.2e-06	5.7e-07	8.2e-06	1.1e-06
2	Adipose	gene expression	LOC120096976	0.05	0.04	4.6e-06	0.03	0.03	0.03	0.03	4.2e-04	1.4e-04	2.5e-04	2.3e-04
3	NAcc	gene expression	LOC120096976	0.1	0.06	6.3e-07	0.04	0.05	0.04	0.04	2.5e-05	1.6e-06	1.4e-05	7.5e-06
4	pVTA	gene expression	LOC120096976	0.18	0.1	2.4e-06	0.11	0.13	0.13	0.13	1.6e-05	3.5e-06	2.6e-06	3.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	0.8	-0.2	-0.4	0.5	-0.9
Area under the delay curve	1.0	1.1	1.3	-1.0	-1.0	-1.1	1.1
BMI with tail	0.4	1.5	1.8	1.1	1.1	1.2	-1.3
BMI without tail	0.2	0.3	0.7	-0.4	-0.4	-0.5	0.8
Body weight	2.1	8.7	10.1	-3.2	-3.1	-3.1	2.4
Weight adjusted by age	0.3	0.3	0.7	0.5	0.4	0.8	-0.4
Bone surface	0.5	0.8	1.6	-1.1	-1.2	-0.6	-0.1
Bone volume	0.4	0.6	1.3	-1.0	-1.1	-0.5	-0.0
Breakpoint value in progressive ratio session	4.0	4.4	5.1	-2.1	-2.1	-2.3	1.8
Number of licking bursts	3.1	3.6	4.7	2.1	2.2	1.8	-1.4
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	0.1	0.2	0.0
Locomotion velocity, session 1	1.2	1.3	1.9	1.0	0.9	1.4	-1.2
Locomotion distance, session 1	0.6	0.7	1.1	-0.9	-0.8	-1.0	0.6
Locomotion velocity, session 2	0.3	0.3	0.4	0.6	0.6	0.6	-0.4
Locomotion distance, session 2	1.3	1.8	1.9	1.4	1.4	1.2	-1.3
Locomotion velocity, session 3	0.4	0.5	0.6	0.7	0.7	0.8	-0.5
Locomotion distance, session 3	3.8	4.1	5.1	-2.0	-1.9	-2.3	1.9
Stereotopy head waving bouts, day 3	1.1	1.3	1.7	1.1	1.0	1.3	-1.1
Stereotopy head waving duration, day 3	2.3	2.8	3.9	1.6	1.5	2.0	-1.5
Locomotion velocity, session 7	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.0
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.0
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	0.8	0.9	0.4	-0.0
Stereotopy head waving duration, day 7	1.4	1.7	2.6	1.5	1.6	1.2	-0.7
Locomotion velocity, session 8	4.0	4.8	5.3	2.3	2.3	2.2	-1.9
Locomotion distance, session 8	0.5	0.7	0.9	1.0	1.0	0.8	-0.7
Degree of sensitization distance	1.5	1.5	2.3	1.1	1.0	1.5	-1.3
Degree of sensitization stereotypy	0.4	0.4	0.9	0.9	1.0	0.3	-0.0
Conditioned locomotion	0.2	0.2	0.3	0.5	0.5	-0.1	0.4
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.1	0.0	-0.5	0.6
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.1	-0.0	-0.3	0.2
Cocaine response before conditioning	0.4	0.5	0.9	-0.9	-0.9	-0.6	0.0
Saline control response	0.3	0.3	0.6	-0.4	-0.3	-0.7	0.8
Bone: connectivity density	0.3	0.5	1.5	0.0	-0.1	0.9	-1.2
Bone: cortical apparent density	2.4	3.1	3.5	1.8	1.8	1.9	-1.5
Bone: cortical area	1.4	2.2	2.6	-1.5	-1.5	-1.6	1.3
Bone: cortical porosity	2.1	2.3	2.4	1.5	1.5	1.6	-1.5
Bone: cortical porosity	2.4	2.6	2.8	1.7	1.6	1.6	-1.5
Bone: cortical thickness	0.5	0.8	1.0	-0.8	-0.7	-1.0	0.9
Bone: cortical thickness	0.7	0.8	1.0	1.0	1.0	0.8	-0.6
Bone: cortical tissue density	2.8	3.6	4.1	2.0	2.0	2.0	-1.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	0.5	0.5	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.4	0.4	0.5	-0.4
Condit. Reinf. active responses	1.7	2.1	2.5	1.6	1.6	1.4	-1.2
Condit. Reinf. inactive responses	1.4	1.6	2.3	1.5	1.5	1.1	-0.9
Incentive salience index mean	0.1	0.1	0.2	0.4	0.4	0.3	-0.3
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1
Condit. Reinf. active minus inactive responses	3.3	4.1	5.0	-1.9	-1.8	-2.2	2.1
Condit. Reinf. active-inactive response ratio	1.0	1.0	2.3	-0.4	-0.2	-1.3	1.5
Condit. Reinf. active responses	4.4	6.1	6.6	-2.6	-2.5	-2.5	2.1
Condit. Reinf. inactive responses	2.9	3.6	5.6	-2.3	-2.4	-1.6	1.1
Condit. Reinf. lever presses	8.6	11.7	13.2	-3.6	-3.6	-3.5	2.9
Condit. Reinf. lever reinforcers received	4.8	6.7	7.5	-2.7	-2.6	-2.7	2.3
Conditioned reinforcement - actives	0.1	0.1	0.2	0.1	0.2	-0.4	0.5
Conditioned reinforcement - inactives	1.4	1.6	2.4	-1.2	-1.1	-1.5	1.2
Conditioned locomotion	1.8	2.1	2.7	1.6	1.6	1.4	-1.1
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.1
Patch foraging indifference point AUC	0.7	0.8	1.0	0.8	0.8	0.8	-1.0
Delay disc. indifference point, 0s delay	1.5	1.7	3.2	-0.9	-0.8	-1.5	1.8
Delay disc. indifference point, 16s delay	3.1	3.1	3.9	-1.7	-1.6	-2.0	1.8
Delay disc. indifference point, 2s delay	1.4	1.5	2.0	-1.2	-1.2	-1.0	1.4
Delay disc. indifference point, 24s delay	2.6	2.5	2.8	-1.7	-1.7	-1.5	1.5
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	-0.3	-0.2	-0.7	0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.5
Indifference point function ln k	0.7	0.9	1.1	-0.9	-0.9	-0.9	1.0
Indifference point function log k	0.7	0.9	1.1	-0.9	-0.9	-0.9	1.0
Patch foraging total patch changes 0 sec	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.2
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	-0.3	-0.3	-0.6	0.4
Patch foraging total patch changes 18 sec	0.3	0.3	0.5	0.4	0.4	0.7	-0.7
Patch foraging total patch changes 24 sec	0.6	0.7	0.9	-0.9	-0.9	-0.9	0.5
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.3
Patch foraging time to switch 0 sec	0.4	0.6	0.8	0.8	0.7	0.9	-0.6
Patch foraging water rate 0 sec	0.7	1.1	1.4	1.1	1.1	1.2	-0.7
Patch foraging water rate 12 sec	0.6	0.9	1.3	-0.9	-0.7	-1.0	1.1
Patch foraging water rate 18 sec	0.1	0.1	0.3	0.3	0.4	0.6	-0.2
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.2	-0.1	-0.5	0.8
Patch foraging water rate 6 sec	0.4	0.5	0.8	-0.9	-0.9	-0.3	0.7
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.2	-1.2	-1.2	-1.5	1.1
Distance traveled before self-admin	1.3	1.3	2.4	-0.7	-0.7	-1.6	1.4
Distance traveled after self-admin	5.6	6.2	6.6	-2.5	-2.4	-2.6	2.5
Extensor digitorum longus weight	0.2	0.7	0.8	0.9	0.9	0.9	-0.5
Bone: elastic displacement	0.0	0.0	0.0	0.0	0.0	0.1	-0.1
Bone: elastic work	1.6	2.1	2.4	-1.5	-1.5	-1.5	1.1
Bone: endosteal estimation	1.4	3.1	3.8	-1.9	-2.0	-1.8	1.2
Bone: endosteal perimeter	1.7	3.5	3.9	-2.0	-2.0	-1.9	1.6
Epididymis fat weight	0.0	0.0	0.1	0.0	0.0	0.3	-0.3
Delta time in closed arm before/after self-admin	1.1	1.1	1.8	-1.3	-1.4	-0.8	0.5
Delta time in open arm before/after self-admin	0.8	0.8	1.1	1.0	1.1	0.9	-0.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.7	-0.3	-0.3	-0.9	0.6
Delay discount exponential model param	1.0	1.1	1.1	1.0	1.0	1.0	-1.1
Extinction: sum of active levers before priming	1.8	1.8	3.0	-1.6	-1.7	-1.2	-0.0
Active lever presses in extinction session 6	2.2	2.1	3.2	-1.7	-1.8	-1.1	1.1
Bone: final force	1.2	1.9	2.4	-1.5	-1.5	-1.4	0.9
Bone: final moment	1.7	2.7	3.3	-1.8	-1.8	-1.8	1.1
Food consumed during 24 hour testing period	0.6	0.7	1.0	-1.0	-1.0	-0.8	0.5
Glucose	0.2	0.3	0.4	0.6	0.6	0.6	-0.5
Heart weight	0.5	0.7	1.7	-0.6	-0.5	-0.7	1.3
Delay discount hyperbolic model param	0.9	0.9	1.2	0.9	0.9	0.9	-1.1
Intermittent access intake day 1-15 change	1.6	1.6	1.8	-1.3	-1.3	-1.2	1.2
Intermittent access intake escalation	1.6	1.6	1.9	-1.3	-1.2	-1.1	1.4
Intermittent access intake escalation 2	2.8	2.8	3.4	-1.5	-1.4	-1.8	1.8
Intermitt. access day 1 inactive lever presses	1.9	2.1	3.7	-1.8	-1.9	-1.0	0.5
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.4	-0.9	-0.9	-0.8	1.2
Intermitt. access escalation Index	0.1	0.1	0.3	0.1	0.1	-0.3	0.5
Intermittent access day 1 total infusions	1.0	1.2	2.0	1.3	1.4	0.6	-0.7
Intermittent access day 15 total infusions	0.5	0.5	1.2	-0.2	-0.1	-0.9	1.1
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.7	-0.2	-0.0	-1.1	1.3
Intermittent access total infusions	0.2	0.2	0.4	0.3	0.4	-0.5	0.7
Intermittent access day 1 locomotion	0.5	0.5	0.7	0.8	0.9	0.5	-0.7
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.2	0.2	0.2	-0.1
Intermittent access total locomotion	0.8	0.9	1.1	1.1	1.1	0.8	-0.7
Intermittent access standard deviation	6.2	6.6	7.4	-2.6	-2.6	-2.7	2.3
Left kidney weight	1.2	3.3	4.2	-2.1	-2.1	-1.8	1.3
Right kidney weight	3.0	8.5	10.8	-3.3	-3.3	-2.9	1.9
Cocaine induced anxiety	0.3	0.3	0.6	-0.7	-0.8	-0.3	0.1
Post-drug Anxiety	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3
Baseline Anxiety	0.7	0.8	1.3	1.1	1.1	0.7	-0.4
Tail length	5.6	17.1	18.3	-4.2	-4.1	-4.3	3.9
Length with tail	8.1	29.7	33.0	-5.7	-5.6	-5.7	4.7
Length without tail	3.4	7.5	9.9	-3.1	-3.1	-2.7	1.8
Times rat made contact with spout	1.1	1.3	1.4	1.2	1.2	1.1	-1.1
Lifetime Intake	0.2	0.3	0.5	0.7	0.7	0.1	0.0
Liver weight, left	0.5	0.7	1.0	1.0	1.0	0.8	-0.6
Liver weight, right	0.0	0.1	0.1	0.3	0.3	0.2	0.1
Locomotor activity	0.6	1.0	1.2	0.9	0.9	1.1	-1.1
Locomotor testing distance	0.9	1.4	1.9	1.0	1.0	1.4	-1.4
Locomotor testing rearing	2.0	3.1	4.0	2.0	2.0	1.9	-1.0
Locomotion in novel chamber	0.1	0.1	0.3	0.1	0.1	0.2	-0.6
Locomotion in novel chamber post-restriction	0.7	0.8	1.0	-0.8	-0.8	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.9	1.0	1.4	1.1	1.0	1.2	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	0.2	0.1	-0.4
Bouts of movement, locomotor time 1	2.5	2.8	3.9	-1.4	-1.4	-1.8	2.0
Total resting periods, locomotor time 1	2.4	2.7	3.6	-1.4	-1.4	-1.7	1.9
Rest time, locomotor task time 1	0.1	0.1	0.1	0.4	0.4	-0.1	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.2	0.3	0.2	-0.3
Vertical activity count, locomotor time 1	0.6	0.6	0.9	-1.0	-1.0	-0.6	0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.7	0.7	0.8	-0.1	0.2
Bouts of movement, locomotor time 2	0.3	0.4	1.0	-0.3	-0.3	-0.5	1.0
Total resting periods, locomotor time 2	0.2	0.2	0.5	-0.2	-0.1	-0.2	0.7
Rest time, locomotor task time 2	0.1	0.1	0.1	0.1	0.2	-0.3	0.3
Distance moved, locomotor task time 2	0.3	0.3	0.4	0.6	0.7	0.5	-0.4
Vertical activity count, locomotor time 2	0.3	0.3	0.5	-0.7	-0.7	-0.5	0.4
Light reinforcement 1	0.2	0.3	0.3	0.5	0.5	0.6	-0.6
Light reinforcement 2	4.0	5.3	7.7	2.2	2.1	2.8	-2.1
Bone: marrow area	1.5	3.2	4.0	-2.0	-2.0	-1.8	1.2
Bone: maximum diameter	1.2	2.2	2.6	-1.6	-1.6	-1.5	1.3
Bone: maximum force	2.2	3.8	4.5	-2.1	-2.1	-2.1	1.4
Bone: maximum moment	2.9	4.9	5.8	-2.4	-2.3	-2.4	1.7
Mean time between licks in bursts	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.3
Mean num. licks in bursts	0.7	0.9	1.2	-1.1	-1.1	-0.9	0.6
Cd content in liver	0.1	0.2	0.3	0.1	0.1	0.5	-0.6
Co content in liver	1.5	1.8	2.7	1.0	0.9	1.6	-1.6
Cu content in liver	0.5	0.6	0.8	-0.8	-0.7	-0.9	0.6
Fe content in liver	0.0	0.1	0.1	0.2	0.1	0.3	-0.3
K content in liver	0.1	0.1	0.1	-0.2	-0.2	-0.4	0.3
Mg content in liver	0.2	0.2	0.4	0.6	0.6	0.4	-0.3
Mn content in liver	0.4	0.5	0.9	0.9	0.9	0.4	-0.4
Na content in liver	3.5	3.7	4.9	-1.7	-1.5	-2.2	2.2
Rb content in liver	0.0	0.0	0.1	-0.0	0.0	-0.1	0.3
Se content in liver	6.8	8.4	10.3	3.2	3.2	2.8	-2.3
Sr content in liver	1.0	0.9	1.0	0.9	0.9	1.0	-0.9
Zn content in liver	0.4	0.4	0.7	0.5	0.4	0.7	-0.8
Bone: minimum diameter	4.5	8.4	10.2	-2.9	-2.8	-3.2	2.7
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	-0.5	-0.6	0.5
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.8	0.9	0.5	-0.2
Total zone transitions, hab. session 1	0.2	0.2	0.6	-0.3	-0.2	-0.7	0.5
Total locomotion distance, hab. session 1	2.9	4.1	5.5	-1.9	-1.8	-2.3	1.9
Locomotion velocity, hab. session 1	1.3	1.9	2.5	-1.4	-1.4	-1.6	1.1
Time in familiar zone, hab. session 2	1.8	1.8	2.8	-1.6	-1.7	-1.1	0.8
Time in novel zone, hab. session 2	1.1	1.1	1.7	1.3	1.3	1.0	-0.6
Total zone transitions, hab. session 2	1.3	1.7	3.1	1.6	1.8	0.8	-0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.1	-0.0	-0.5	0.5
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.1	0.2	-0.3	0.2
Novel to familiar place preference ratio	0.6	0.6	1.0	-0.6	-0.5	-1.0	1.0
Novelty place preference	0.5	0.5	0.8	-0.5	-0.4	-0.9	0.9
Time in novel zone, NPP test	0.3	0.3	0.5	-0.2	-0.1	-0.7	0.7
Total zone transitions, NPP test	0.2	0.2	0.5	0.4	0.3	0.4	-0.7
Total locomotion distance, NPP test	2.3	3.2	3.9	-2.0	-2.0	-1.8	1.3
Locomotion velocity, NPP test	2.6	3.7	4.4	-2.1	-2.1	-2.0	1.4
Intraocular pressure	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.0
Delta distance traveled before/after self-admin	2.4	2.6	3.9	-1.9	-2.0	-1.1	1.2
Delta ambulatory time before/after self-admin	2.2	2.4	3.8	-1.9	-1.9	-1.1	1.0
Parametrial fat weight	1.0	2.0	3.0	1.1	1.0	1.7	-1.7
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	-0.4	-0.1	0.0
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.5	0.6	0.3	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.3	0.3	0.1	-0.0
Pavlov. Cond. index score	0.2	0.3	0.5	0.6	0.7	0.4	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	0.4	0.2	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.6	-0.7	-0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.9	0.9	0.6	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.7	0.8	0.3	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.1	0.2	0.2	-0.1	0.1
Pavlov. Cond. lever latency	4.4	6.0	7.3	2.7	2.7	2.4	-1.9
Pavlov. Cond. magazine entry latency	3.0	3.4	4.2	-2.0	-2.1	-1.8	1.5
Pavlov. Cond. change in total contacts	8.3	11.4	12.9	-3.6	-3.6	-3.4	2.9
Pavlov. Cond. index score	4.7	6.0	7.3	-2.7	-2.7	-2.4	1.9
Pavlov. Cond. latency score	4.4	5.5	6.8	-2.6	-2.6	-2.3	1.8
Pavlov. Cond. lever contacts	4.1	5.7	6.6	-2.6	-2.6	-2.4	1.9
Pavlov. Cond. magazine entry number	2.9	3.6	4.7	2.1	2.2	1.8	-1.4
Pavlov. Cond. intertrial magazine entries	2.1	2.8	3.6	1.5	1.5	1.7	-1.9
Pavlov. Cond. lever-magazine prob. diff.	4.7	6.0	7.1	-2.7	-2.7	-2.5	1.9
Pavlov. Cond. response bias	4.6	6.2	7.3	-2.7	-2.7	-2.5	2.0
Time in closed arm before self-admin	0.7	0.8	1.6	1.2	1.3	0.3	0.2
Time in closed arm after self-admin	0.6	0.7	1.1	-0.7	-0.7	-1.1	0.7
Time in open arm before self-admin	1.9	2.0	3.7	-1.8	-1.9	-1.1	0.3
Time in open arm after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.1	-0.2
Bone: periosteal estimation	1.9	3.9	4.5	-2.1	-2.1	-2.1	1.6
Bone: periosteal perimeter	2.1	3.6	4.1	-1.9	-1.8	-2.0	1.8
Bone: post-yield work	1.4	1.9	2.5	-1.6	-1.6	-1.3	0.9
Progressive ratio test 1 active lever presses	0.4	0.5	0.8	-0.7	-0.7	-0.9	0.3
Progressive ratio test 1 breakpoint	0.8	0.8	1.3	-0.9	-0.9	-1.1	0.5
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.0	-0.9	-0.9	-0.9	1.0
Progressive ratio test 2 active lever presses	0.5	0.6	1.1	-0.4	-0.4	-1.0	1.0
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	-0.3	-0.3	-0.9	0.8
Progressive ratio test 2 inactive lever presses	3.7	4.2	6.6	-1.8	-1.7	-2.6	2.0
Incentive Sensitization - Responses	0.2	0.2	0.6	-0.1	-0.0	-0.5	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.0	0.0	-0.3	0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.3
Progressive ratio	0.0	0.0	0.1	-0.0	-0.1	0.3	0.0
Food seeking constrained by brief footshock	3.3	4.0	5.0	-2.2	-2.2	-2.0	1.4
Seeking ratio, punishment vs. effort	0.9	1.1	1.9	-1.1	-1.0	-1.4	0.7
Retroperitoneal fat weight	1.7	5.7	6.5	2.6	2.6	2.5	-1.9
Reaction time number correct	0.2	0.2	0.4	0.5	0.5	0.7	-0.1
Reaction time mean minus median	0.1	0.2	0.2	-0.5	-0.5	-0.2	-0.4
Reaction time mean minus median AUC	0.2	0.2	0.3	-0.6	-0.6	-0.1	-0.5
Reaction time num false alarms	1.2	1.7	1.9	1.4	1.4	1.3	-1.1
Reaction time num false alarms AUC	1.6	2.2	2.5	1.5	1.5	1.6	-1.4
Reaction time trials correct on left	0.2	0.2	0.4	0.5	0.5	0.7	-0.1
Reaction time trials on left	0.2	0.3	0.5	0.5	0.5	0.7	-0.1
Reaction time mean	0.1	0.2	0.5	0.1	0.1	0.5	-0.7
Reaction time mean AUC	0.4	0.5	1.2	0.4	0.3	0.8	-1.1
Median of all reaction times	0.2	0.3	0.5	0.4	0.3	0.7	-0.7
Reaction time omissions	0.4	0.5	0.8	0.5	0.5	0.9	-0.9
Reaction time false alarm rate	0.7	1.0	1.1	1.0	1.0	1.0	-1.1
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.2
Reaction time premature initiations	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3
Std. dev. reaction times	0.1	0.2	0.5	-0.4	-0.4	0.1	-0.7
Reaction time trials completed	0.2	0.3	0.5	0.5	0.5	0.7	-0.1
Reaction time trials AUC	0.3	0.5	0.8	0.7	0.7	0.9	-0.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.1	-0.1	0.6	-0.4
Run reversals in cocaine runway, males	1.5	1.5	2.7	0.9	0.8	1.6	-1.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	0.1	0.3	0.1
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.5	0.5	0.9	0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.1
Std. dev. time between licks in bursts	1.2	1.5	1.9	-1.1	-1.1	-1.3	1.4
Total sessions with >9 infusions	1.3	1.5	2.0	1.4	1.4	1.1	-0.9
Short access day 1 total inactive lever presses	1.1	1.3	2.0	-0.9	-0.8	-1.2	1.4
Short access day 10 total inactive lever presses	1.8	2.0	2.6	-1.5	-1.6	-1.2	1.2
Short access day 1 total infusions	0.1	0.1	0.1	0.3	0.3	-0.2	0.3
Short access day 10 total infusions	0.9	1.0	1.9	0.9	0.9	0.8	-1.4
Short access total infusions	1.2	1.4	1.6	1.2	1.2	1.0	-1.2
Short access day 1 locomotion	2.9	3.1	4.5	1.4	1.4	2.0	-2.1
Short access day 10 total locomotion	0.3	0.3	0.5	-0.6	-0.7	-0.4	-0.6
Short access total locomotion	1.4	1.5	2.3	1.1	1.1	1.0	-1.5
One hour access (0.3 mA shock)	1.5	1.8	2.3	-1.3	-1.3	-1.5	1.3
Compulsive drug intake	1.0	1.0	2.7	-0.6	-0.5	-0.8	1.7
One hour access (shock baseline)	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.1
Social response proportion	3.9	4.3	4.8	-2.0	-2.0	-2.1	2.2
Social responses	0.5	0.6	1.2	-1.0	-1.1	-0.4	0.5
Social time	1.8	2.3	3.5	-1.8	-1.9	-1.3	1.0
Soleus weight	0.4	1.1	1.6	0.8	0.7	1.3	-1.2
Bone: stiffness	1.3	2.0	2.3	-1.5	-1.5	-1.5	1.1
Tibialis anterior weight	0.0	0.1	0.2	0.4	0.4	0.2	-0.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.9	0.9	1.0	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.2	-0.7	-0.7	-0.9	1.1
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.8	0.9	0.4	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.3	0.4	0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	-0.9	-0.9	-0.6	0.5
Delta time to tail flick, test, before/after SA	0.3	0.2	0.7	0.2	0.2	0.4	-0.8
Tibia length	1.6	4.4	5.7	-2.4	-2.4	-2.1	1.3
Ambulatory time before self-admin	0.7	0.7	1.5	-0.6	-0.5	-1.2	0.8
Ambulatory time after self-admin	6.9	7.6	9.2	-3.0	-3.0	-2.7	2.2
Bone: tissue strength	3.6	3.5	4.1	-1.9	-1.9	-2.0	1.6
Total heroin consumption	1.1	1.3	2.4	-1.1	-1.1	-1.5	0.4
Bone: trabecular number	0.3	0.5	1.0	-0.9	-1.0	-0.2	-0.3
Bone: trabecular spacing	1.3	1.7	2.5	-1.1	-0.9	-1.5	1.6
Bone: trabecular thickness	0.5	0.6	0.7	0.7	0.7	0.9	-0.8
Bone: trabecular tissue density	2.3	3.2	3.8	1.9	1.9	1.9	-1.4
Water consumed over 24 hours	0.1	0.2	0.2	-0.4	-0.5	-0.4	0.1
Number of responses in last shaping day	1.1	1.1	2.8	-0.6	-0.5	-1.7	1.1