Hub : Genes

LOC120096643

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC120096643 0.02 0.02 4.8e-03 0.01 0.02 0 0.01 2.0e-02 5.7e-03 2.9e-01 2.5e-02
2 Brain gene expression LOC120096643 0.03 0.02 3.3e-03 0.02 0.02 0.01 0.02 1.1e-02 2.3e-03 8.6e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.11.91.91.4-1.4
Area under the delay curve0.10.10.2-0.30.4
BMI with tail2.69.19.5-2.93.1
BMI without tail2.16.56.7-2.52.6
Body weight6.528.529.1-5.35.4
Weight adjusted by age2.53.83.9-1.92.0
Bone surface0.00.00.0-0.10.1
Bone volume0.10.10.10.3-0.3
Breakpoint value in progressive ratio session0.00.00.00.1-0.1
Number of licking bursts1.11.81.9-1.41.3
Context. condit. distance diff. score0.20.30.30.5-0.5
Locomotion velocity, session 11.21.21.31.1-1.1
Locomotion distance, session 10.50.70.70.8-0.8
Locomotion velocity, session 26.17.07.42.6-2.7
Locomotion distance, session 23.95.55.62.4-2.3
Locomotion velocity, session 30.40.40.40.7-0.6
Locomotion distance, session 30.00.00.00.1-0.0
Stereotopy head waving bouts, day 30.20.20.30.5-0.5
Stereotopy head waving duration, day 30.20.20.20.4-0.5
Locomotion velocity, session 70.50.50.6-0.70.7
Locomotion distance, session 70.30.40.50.7-0.6
Stereotopy head waving bouts, day 71.61.81.9-1.31.4
Stereotopy head waving duration, day 72.73.23.3-1.71.8
Locomotion velocity, session 81.82.22.31.4-1.5
Locomotion distance, session 82.33.43.41.8-1.9
Degree of sensitization distance1.11.21.31.0-1.1
Degree of sensitization stereotypy2.32.52.6-1.51.6
Conditioned locomotion0.00.00.00.10.0
Cocaine response after cond. corrected1.41.71.71.3-1.3
Cocaine response after cond. not corrected0.50.60.70.8-0.8
Cocaine response before conditioning0.80.91.0-1.00.9
Saline control response0.20.20.20.4-0.5
Bone: connectivity density0.81.31.31.2-1.1
Bone: cortical apparent density0.40.60.6-0.70.8
Bone: cortical area5.68.68.7-2.92.9
Bone: cortical porosity0.40.50.50.7-0.7
Bone: cortical porosity0.00.00.00.2-0.1
Bone: cortical thickness4.06.66.7-2.52.6
Bone: cortical thickness0.00.00.00.00.1
Bone: cortical tissue density0.40.50.6-0.70.8
Condit. Reinf. active minus inactive responses1.11.21.21.1-1.1
Condit. Reinf. active-inactive response ratio2.83.03.01.7-1.7
Condit. Reinf. active responses0.40.40.50.7-0.6
Condit. Reinf. inactive responses1.21.51.5-1.21.2
Incentive salience index mean0.10.10.10.3-0.2
Condit. Reinf. lever presses0.60.80.9-0.90.9
Condit. Reinf. active minus inactive responses0.30.40.5-0.70.6
Condit. Reinf. active-inactive response ratio0.10.10.10.3-0.2
Condit. Reinf. active responses0.00.00.10.2-0.3
Condit. Reinf. inactive responses0.10.10.10.3-0.4
Condit. Reinf. lever presses0.30.50.5-0.70.7
Condit. Reinf. lever reinforcers received0.00.00.0-0.0-0.0
Conditioned reinforcement - actives0.30.50.5-0.60.7
Conditioned reinforcement - inactives0.60.80.8-0.90.9
Conditioned locomotion1.01.31.4-1.11.2
Patch foraging indifference point 0 sec0.00.10.1-0.30.2
Patch foraging indifference point AUC0.20.20.30.4-0.5
Delay disc. indifference point, 0s delay0.10.10.2-0.10.4
Delay disc. indifference point, 16s delay0.10.10.10.4-0.3
Delay disc. indifference point, 2s delay0.10.10.10.3-0.2
Delay disc. indifference point, 24s delay0.00.00.1-0.10.3
Delay disc. indifference point, 4s delay0.20.20.30.5-0.4
Delay disc. indifference point, 8s delay0.80.90.9-0.91.0
Indifference point function ln k0.10.30.30.5-0.5
Indifference point function log k0.10.30.30.5-0.5
Patch foraging total patch changes 0 sec0.10.10.1-0.40.3
Patch foraging total patch changes 12 sec0.40.60.6-0.70.8
Patch foraging total patch changes 18 sec0.00.00.0-0.20.2
Patch foraging total patch changes 24 sec0.10.10.1-0.30.3
Patch foraging total patch changes 6 sec0.20.30.3-0.60.5
Patch foraging time to switch 0 sec0.71.51.7-1.11.3
Patch foraging water rate 0 sec0.30.50.7-0.80.6
Patch foraging water rate 12 sec0.00.00.0-0.1-0.0
Patch foraging water rate 18 sec0.20.30.4-0.60.5
Patch foraging water rate 24 sec0.91.21.5-1.21.0
Patch foraging water rate 6 sec1.42.12.3-1.51.4
Seeking ratio, delayed vs. immediate footshock2.02.42.61.5-1.6
Distance traveled before self-admin1.41.81.81.4-1.3
Distance traveled after self-admin0.10.20.20.5-0.3
Extensor digitorum longus weight3.212.712.9-3.63.5
Bone: elastic displacement0.80.91.0-1.01.0
Bone: elastic work4.15.45.6-2.42.3
Bone: endosteal estimation0.71.51.6-1.31.2
Bone: endosteal perimeter0.71.51.6-1.31.2
Epididymis fat weight2.06.87.1-2.62.7
Delta time in closed arm before/after self-admin0.90.80.90.9-0.9
Delta time in open arm before/after self-admin1.51.51.5-1.21.2
Diff in mean of infusions in LGA sessions1.41.71.91.4-1.2
Delay discount exponential model param0.10.10.10.2-0.3
Extinction: sum of active levers before priming0.70.80.9-0.90.9
Active lever presses in extinction session 60.00.00.00.10.0
Bone: final force4.57.27.2-2.72.7
Bone: final moment3.96.36.4-2.52.5
Food consumed during 24 hour testing period0.00.00.0-0.1-0.1
Glucose0.00.00.0-0.0-0.1
Heart weight1.01.61.6-1.31.2
Delay discount hyperbolic model param0.00.00.10.1-0.3
Intermittent access intake day 1-15 change2.75.65.62.4-2.4
Intermittent access intake escalation1.83.73.71.9-1.9
Intermittent access intake escalation 22.73.13.21.7-1.8
Intermitt. access day 1 inactive lever presses0.10.50.50.7-0.7
Intermitt. access day 15 inactive lever presses0.40.70.80.8-0.9
Intermitt. access escalation Index0.81.11.11.1-1.1
Intermittent access day 1 total infusions0.50.91.0-0.91.0
Intermittent access day 15 total infusions0.00.00.00.2-0.1
Intermittent access terminal intake (last 3 days)0.10.10.10.3-0.3
Intermittent access total infusions0.10.10.1-0.30.3
Intermittent access day 1 locomotion0.50.70.7-0.80.8
Intermittent access day 15 total locomotion0.10.20.2-0.40.5
Intermittent access total locomotion0.00.00.0-0.00.1
Intermittent access standard deviation0.30.70.70.8-0.8
Left kidney weight5.123.723.7-4.94.9
Right kidney weight3.817.517.9-4.14.2
Cocaine induced anxiety0.50.70.70.8-0.9
Post-drug Anxiety0.30.30.30.6-0.5
Baseline Anxiety1.31.51.8-1.11.3
Tail length1.03.84.0-2.01.9
Length with tail3.916.817.2-4.24.1
Length without tail3.110.010.0-3.23.1
Times rat made contact with spout0.91.11.21.0-1.1
Lifetime Intake0.10.10.1-0.40.4
Liver weight, left0.40.70.8-0.90.9
Liver weight, right3.76.56.6-2.52.6
Locomotor activity0.10.10.2-0.40.2
Locomotor testing distance0.71.31.3-1.21.1
Locomotor testing rearing1.32.62.8-1.71.6
Locomotion in novel chamber0.50.70.70.8-0.8
Locomotion in novel chamber post-restriction0.20.30.30.6-0.5
Fecal boli incidents, locomotor time 10.30.40.50.6-0.7
Change in fecal boli incidents, locomotor task0.40.40.40.6-0.7
Time >=10cm from walls, locomotor time 11.31.31.5-1.11.2
Bouts of movement, locomotor time 10.10.10.1-0.30.4
Total resting periods, locomotor time 10.10.10.1-0.30.4
Rest time, locomotor task time 11.72.22.2-1.51.4
Distance moved, locomotor task time 10.00.10.10.3-0.3
Vertical activity count, locomotor time 10.61.51.51.2-1.2
Time >=10cm from walls, locomotor time 20.50.70.8-0.80.9
Bouts of movement, locomotor time 20.00.00.00.2-0.1
Total resting periods, locomotor time 20.00.00.0-0.10.2
Rest time, locomotor task time 21.21.61.6-1.31.2
Distance moved, locomotor task time 20.60.70.70.8-0.8
Vertical activity count, locomotor time 21.82.42.51.6-1.5
Light reinforcement 12.25.35.4-2.32.3
Light reinforcement 22.94.54.6-2.12.1
Bone: marrow area0.51.21.3-1.11.1
Bone: maximum diameter4.58.48.6-2.92.9
Bone: maximum force3.46.06.1-2.52.4
Bone: maximum moment2.95.15.3-2.32.2
Mean time between licks in bursts0.61.51.71.1-1.3
Mean num. licks in bursts2.74.24.22.1-2.1
Cd content in liver0.10.10.10.3-0.3
Co content in liver0.00.10.1-0.20.2
Cu content in liver1.51.71.81.3-1.3
Fe content in liver4.85.86.02.5-2.4
K content in liver0.10.10.10.3-0.2
Mg content in liver1.01.11.1-1.01.1
Mn content in liver0.50.50.60.7-0.8
Na content in liver0.60.70.80.9-0.8
Rb content in liver0.10.10.1-0.20.3
Se content in liver0.00.00.00.1-0.0
Sr content in liver2.72.32.4-1.61.5
Zn content in liver0.40.40.5-0.70.6
Bone: minimum diameter0.91.71.8-1.31.3
Time in familiar zone, hab. session 10.70.70.70.8-0.8
Time in novel zone, hab. session 10.70.70.7-0.80.8
Total zone transitions, hab. session 10.20.20.20.5-0.5
Total locomotion distance, hab. session 10.81.11.21.1-1.1
Locomotion velocity, hab. session 10.50.70.70.8-0.8
Time in familiar zone, hab. session 23.73.94.02.0-1.9
Time in novel zone, hab. session 27.87.98.2-2.92.8
Total zone transitions, hab. session 20.10.10.1-0.30.3
Total locomotion distance, hab. session 20.00.00.0-0.20.1
Locomotion velocity, hab. session 20.00.00.0-0.10.0
Novel to familiar place preference ratio0.20.20.20.5-0.4
Novelty place preference0.10.10.10.3-0.2
Time in novel zone, NPP test0.00.00.00.1-0.1
Total zone transitions, NPP test0.10.10.10.3-0.3
Total locomotion distance, NPP test0.50.70.70.8-0.8
Locomotion velocity, NPP test0.91.21.31.1-1.1
Intraocular pressure0.40.60.6-0.80.7
Delta distance traveled before/after self-admin0.50.50.6-0.60.8
Delta ambulatory time before/after self-admin0.10.10.10.3-0.3
Parametrial fat weight0.20.50.50.7-0.6
Pavlov. Cond. lever latency0.70.90.90.9-1.0
Pavlov. Cond. magazine entry latency0.50.60.60.8-0.8
Pavlov. Cond. change in total contacts0.00.00.00.2-0.2
Pavlov. Cond. index score0.10.10.10.3-0.3
Pavlov. Cond. latency score0.00.00.00.1-0.0
Pavlov. Cond. lever contacts0.40.40.4-0.60.7
Pavlov. Cond. magazine entry number1.01.31.3-1.11.2
Pavlov. Cond. intertrial magazine entries0.40.50.5-0.70.7
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.2-0.2
Pavlov. Cond. response bias0.10.20.20.4-0.4
Pavlov. Cond. lever latency0.50.70.7-0.80.8
Pavlov. Cond. magazine entry latency1.41.71.7-1.31.3
Pavlov. Cond. change in total contacts0.00.00.0-0.10.1
Pavlov. Cond. index score0.00.00.0-0.20.1
Pavlov. Cond. latency score0.00.00.0-0.10.1
Pavlov. Cond. lever contacts1.01.31.41.1-1.2
Pavlov. Cond. magazine entry number2.12.62.71.6-1.6
Pavlov. Cond. intertrial magazine entries0.91.41.41.2-1.2
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.30.2
Pavlov. Cond. response bias0.00.00.00.2-0.2
Time in closed arm before self-admin0.10.20.2-0.50.4
Time in closed arm after self-admin0.30.30.30.5-0.5
Time in open arm before self-admin0.20.20.2-0.50.4
Time in open arm after self-admin1.41.61.6-1.21.3
Bone: periosteal estimation3.06.26.4-2.52.5
Bone: periosteal perimeter3.35.65.7-2.42.4
Bone: post-yield work0.30.40.50.6-0.7
Progressive ratio test 1 active lever presses0.81.01.0-1.01.0
Progressive ratio test 1 breakpoint0.80.91.0-0.91.0
Progressive ratio test 1 inactive lever presses0.20.30.3-0.50.5
Progressive ratio test 2 active lever presses0.00.00.0-0.00.1
Progressive ratio test 2 breakpoint0.00.00.0-0.10.1
Progressive ratio test 2 inactive lever presses0.30.40.5-0.60.7
Incentive Sensitization - Responses0.10.10.10.4-0.3
Incentive Sensitization - Breakpoint0.10.10.10.3-0.3
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.0
Progressive ratio0.10.10.1-0.30.4
Food seeking constrained by brief footshock1.21.51.5-1.21.2
Seeking ratio, punishment vs. effort0.00.00.0-0.10.0
Retroperitoneal fat weight0.31.21.4-1.01.2
Reaction time number correct1.12.12.5-1.61.3
Reaction time mean minus median0.71.71.71.3-1.3
Reaction time mean minus median AUC0.00.10.1-0.30.3
Reaction time num false alarms0.70.91.1-0.91.1
Reaction time num false alarms AUC1.32.02.3-1.31.5
Reaction time trials correct on left1.12.12.5-1.61.3
Reaction time trials on left1.01.92.2-1.51.3
Reaction time mean1.32.12.21.5-1.4
Reaction time mean AUC1.21.92.11.4-1.3
Median of all reaction times1.31.81.91.4-1.3
Reaction time omissions0.30.40.40.7-0.6
Reaction time false alarm rate0.30.40.6-0.50.8
Reaction time premature initiation rate0.00.10.1-0.20.3
Reaction time premature initiations0.50.91.0-1.00.9
Std. dev. reaction times0.51.01.01.0-0.9
Reaction time trials completed1.01.92.2-1.51.3
Reaction time trials AUC0.91.72.1-1.41.2
Run reversals in cocaine runway, females1.81.72.01.4-1.2
Run reversals in cocaine runway, males0.20.20.2-0.50.5
Latency to leave start box in cocaine runway0.91.11.1-1.01.1
Latency to leave start box in cocaine runway, F2.52.82.9-1.71.7
Latency to leave start box in cocaine runway, M0.00.00.00.1-0.1
Std. dev. time between licks in bursts0.30.30.40.5-0.6
Total sessions with >9 infusions0.00.10.1-0.20.3
Short access day 1 total inactive lever presses0.00.00.0-0.20.2
Short access day 10 total inactive lever presses0.30.70.80.8-0.9
Short access day 1 total infusions0.00.00.0-0.00.1
Short access day 10 total infusions0.00.00.0-0.10.0
Short access total infusions0.00.00.00.0-0.0
Short access day 1 locomotion0.30.40.5-0.60.7
Short access day 10 total locomotion1.22.22.31.4-1.5
Short access total locomotion0.40.50.50.7-0.7
One hour access (0.3 mA shock)0.00.00.0-0.20.2
Compulsive drug intake0.10.10.20.4-0.4
One hour access (shock baseline)0.00.00.0-0.20.2
Social response proportion0.91.01.10.9-1.1
Social responses0.10.10.2-0.40.2
Social time1.52.12.11.4-1.5
Soleus weight3.710.811.3-3.43.2
Bone: stiffness0.40.70.7-0.80.8
Tibialis anterior weight1.86.06.1-2.52.4
Time to tail flick, vehicle, before self-admin0.50.60.60.8-0.7
Time to tail flick, vehicle, after self-admin0.40.50.50.7-0.7
Time to tail flick, test, before self-admin0.10.10.1-0.30.3
Time to tail flick, test, after self-admin0.50.50.6-0.80.6
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.30.3
Delta time to tail flick, test, before/after SA0.00.00.0-0.20.0
Tibia length0.82.32.3-1.51.5
Ambulatory time before self-admin0.81.31.41.2-1.1
Ambulatory time after self-admin1.41.71.91.4-1.2
Bone: tissue strength2.12.12.4-1.61.4
Total heroin consumption0.70.80.8-0.90.9
Bone: trabecular number0.30.50.50.7-0.7
Bone: trabecular spacing1.31.81.8-1.41.3
Bone: trabecular thickness1.21.41.51.2-1.2
Bone: trabecular tissue density0.40.60.60.8-0.8
Water consumed over 24 hours0.81.11.31.0-1.1
Number of responses in last shaping day0.10.10.20.4-0.2