Hub : Genes

LOC120095308

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC120095308	0.95	0.02	0.0e+00	0.56	0.58	0.58	0.57	3.6e-74	7.4e-79	5.5e-78	1.2e-77
2	Adipose	gene expression	LOC120095308	0.39	0.34	0.0e+00	0.22	0.23	0.22	0.22	8.6e-24	3.9e-25	3.3e-24	1.8e-24
3	LHb	gene expression	LOC120095308	0.19	0.13	7.9e-03	0.09	0.02	0.05	0.05	3.8e-03	1.2e-01	2.7e-02	2.7e-02
4	Brain	gene expression	LOC120095308	0.08	0.05	2.9e-04	0.04	0.04	0.04	0.04	2.2e-04	1.8e-04	2.1e-04	2.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	-0.0	0.1	-0.3	0.3
Area under the delay curve	0.8	0.8	1.3	1.1	1.1	-0.6	0.6
BMI with tail	0.1	0.2	0.5	0.1	0.2	-0.7	0.3
BMI without tail	0.3	0.5	1.0	0.1	0.3	-1.0	1.0
Body weight	1.4	6.0	8.9	-3.0	-2.8	2.3	-1.5
Weight adjusted by age	1.7	1.9	2.3	-1.4	-1.4	1.5	-1.2
Bone surface	0.3	0.5	0.7	-0.9	-0.8	0.7	-0.3
Bone volume	0.1	0.1	0.2	-0.5	-0.4	0.2	-0.1
Breakpoint value in progressive ratio session	0.7	0.7	2.1	-0.6	-0.6	-0.2	-1.5
Number of licking bursts	0.1	0.1	0.3	-0.1	-0.1	0.3	0.6
Context. condit. distance diff. score	1.4	1.7	2.6	1.1	1.1	-1.3	1.6
Locomotion velocity, session 1	0.1	0.1	0.3	0.1	0.1	0.3	-0.6
Locomotion distance, session 1	3.0	3.9	4.8	2.2	2.1	-1.7	1.8
Locomotion velocity, session 2	0.9	1.0	1.7	1.3	1.1	-0.7	0.7
Locomotion distance, session 2	1.2	1.7	1.9	1.4	1.3	-1.2	1.4
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.4	-0.1	-0.1
Locomotion distance, session 3	1.3	1.5	2.0	1.4	1.3	-1.2	0.7
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.0	-0.0	0.2	-0.3
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.2	0.1	-0.1	-0.0
Locomotion velocity, session 7	0.6	0.7	0.9	0.9	0.9	-1.0	0.6
Locomotion distance, session 7	5.6	7.1	7.9	2.8	2.7	-2.8	2.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	0.9	-0.9	-0.8	0.9	-0.5
Locomotion velocity, session 8	2.1	2.5	2.8	1.6	1.6	-1.5	1.7
Locomotion distance, session 8	3.7	5.5	7.4	2.2	2.2	-2.3	2.7
Degree of sensitization distance	0.4	0.4	0.6	0.5	0.5	-0.8	0.7
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1
Conditioned locomotion	0.3	0.3	0.7	-0.8	-0.7	0.3	0.1
Cocaine response after cond. corrected	0.1	0.1	0.5	0.0	0.0	-0.3	-0.7
Cocaine response after cond. not corrected	0.1	0.1	0.1	0.4	0.4	-0.3	-0.3
Cocaine response before conditioning	0.5	0.6	1.2	0.8	0.7	-0.2	1.1
Saline control response	1.4	1.9	2.6	-1.6	-1.5	1.4	-0.8
Bone: connectivity density	0.3	0.5	1.2	0.5	0.5	-0.6	1.1
Bone: cortical apparent density	0.9	1.2	1.7	1.3	1.2	-1.1	0.4
Bone: cortical area	4.7	7.1	9.3	-3.1	-2.9	2.6	-2.1
Bone: cortical porosity	5.0	5.4	7.5	-2.3	-2.3	2.0	-2.7
Bone: cortical porosity	3.9	4.3	5.8	-2.1	-2.0	1.6	-2.4
Bone: cortical thickness	5.6	9.2	11.3	-3.4	-3.2	2.7	-2.8
Bone: cortical thickness	1.4	1.6	2.0	-1.4	-1.3	1.0	-1.3
Bone: cortical tissue density	1.0	1.3	2.0	1.4	1.3	-1.2	0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.9	-0.8	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.4
Condit. Reinf. active responses	0.9	1.1	1.7	-1.3	-1.2	1.1	-0.5
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.2
Incentive salience index mean	0.4	0.5	0.7	-0.9	-0.8	0.7	-0.3
Condit. Reinf. lever presses	0.1	0.2	0.5	0.3	0.3	-0.1	0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.1
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.4	-1.5	-1.5	1.4	-1.1
Condit. Reinf. active responses	0.1	0.2	0.3	0.4	0.4	-0.6	0.4
Condit. Reinf. inactive responses	1.5	1.8	2.4	1.4	1.4	-1.6	0.9
Condit. Reinf. lever presses	0.7	0.9	2.0	0.8	0.8	-1.4	0.6
Condit. Reinf. lever reinforcers received	0.5	0.7	1.5	0.8	0.8	-1.2	0.6
Conditioned reinforcement - actives	0.1	0.1	0.5	0.2	0.1	0.2	0.7
Conditioned reinforcement - inactives	1.1	1.2	1.4	-1.2	-1.2	1.1	-0.9
Conditioned locomotion	0.3	0.3	0.7	-0.5	-0.6	0.9	0.1
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.2	-0.1	-0.2	-0.3
Patch foraging indifference point AUC	0.1	0.1	0.1	0.4	0.3	-0.2	0.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	0.0	0.2	0.1
Delay disc. indifference point, 16s delay	3.6	3.6	4.1	2.0	2.0	-1.8	1.8
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.2	0.1	0.1	-0.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.4	1.2	1.1	-0.4	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	0.3	-0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.2	0.2	0.5	-0.2
Indifference point function ln k	0.7	1.0	1.6	1.0	1.0	-1.3	0.7
Indifference point function log k	0.7	1.0	1.6	1.0	1.0	-1.3	0.7
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.1	0.1	-0.6	-0.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.5
Patch foraging total patch changes 18 sec	1.3	1.6	2.6	1.2	1.3	-1.6	0.9
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.3
Patch foraging total patch changes 6 sec	0.7	1.0	1.1	-1.1	-1.0	1.0	-1.0
Patch foraging time to switch 0 sec	0.0	0.1	0.1	0.3	0.3	-0.1	0.2
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.2
Patch foraging water rate 12 sec	1.0	1.5	2.9	1.0	1.0	-1.7	0.9
Patch foraging water rate 18 sec	0.3	0.5	0.8	0.4	0.5	-0.9	0.8
Patch foraging water rate 24 sec	1.0	1.4	3.3	0.8	0.9	-1.8	1.0
Patch foraging water rate 6 sec	0.3	0.4	0.7	0.5	0.5	-0.8	0.7
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.8	-0.9	-0.9	1.4	-0.4
Distance traveled before self-admin	1.5	1.6	2.5	-1.3	-1.2	0.8	-1.6
Distance traveled after self-admin	0.3	0.3	1.1	0.3	0.4	-1.0	0.2
Extensor digitorum longus weight	0.7	2.9	3.5	1.6	1.6	-1.9	1.7
Bone: elastic displacement	1.4	1.6	1.9	-1.4	-1.3	0.9	-1.4
Bone: elastic work	8.8	11.3	13.1	-3.6	-3.5	2.8	-3.5
Bone: endosteal estimation	0.5	1.0	1.4	1.0	1.0	-0.9	1.2
Bone: endosteal perimeter	0.6	1.2	1.7	-1.2	-1.1	1.3	-0.6
Epididymis fat weight	0.0	0.1	0.3	-0.5	-0.4	0.1	0.2
Delta time in closed arm before/after self-admin	0.4	0.3	0.7	-0.4	-0.5	0.9	0.5
Delta time in open arm before/after self-admin	0.4	0.4	0.5	0.7	0.7	-0.7	0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Delay discount exponential model param	0.7	0.8	1.3	-1.2	-1.1	0.6	-0.5
Extinction: sum of active levers before priming	0.6	0.6	1.8	0.7	0.6	-1.3	-0.1
Active lever presses in extinction session 6	0.4	0.4	1.4	-0.2	-0.3	-0.2	-1.2
Bone: final force	3.0	4.8	6.6	-2.6	-2.4	1.9	-1.8
Bone: final moment	3.8	6.1	8.3	-2.9	-2.7	2.1	-2.2
Food consumed during 24 hour testing period	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.3
Glucose	0.6	0.9	3.6	-0.1	-0.2	-0.0	-1.9
Heart weight	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4
Delay discount hyperbolic model param	0.7	0.8	1.3	-1.1	-1.0	0.6	-0.5
Intermittent access intake day 1-15 change	0.4	0.4	0.5	-0.7	-0.6	0.2	-0.7
Intermittent access intake escalation	0.2	0.2	0.2	-0.5	-0.5	0.2	-0.4
Intermittent access intake escalation 2	2.3	2.3	2.7	-1.6	-1.6	1.0	-1.7
Intermitt. access day 1 inactive lever presses	1.0	1.1	1.4	-1.1	-0.9	1.0	-1.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.0	0.1
Intermitt. access escalation Index	0.3	0.2	0.6	-0.2	-0.1	0.6	0.7
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.2	-0.2	0.4	-0.0
Intermittent access day 15 total infusions	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.0	-0.9	-1.0	1.0	-0.5
Intermittent access total infusions	0.1	0.1	0.3	-0.4	-0.4	0.5	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.3	0.5	0.2
Intermittent access day 15 total locomotion	0.7	0.8	1.0	-0.9	-1.0	1.0	-0.6
Intermittent access total locomotion	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.3
Intermittent access standard deviation	0.6	0.6	1.7	-0.5	-0.6	0.2	-1.3
Left kidney weight	0.8	2.3	4.1	-1.4	-1.4	2.0	-1.0
Right kidney weight	0.3	0.8	1.9	-0.8	-0.8	1.4	-0.2
Cocaine induced anxiety	5.5	6.4	8.9	-2.6	-2.5	2.0	-3.0
Post-drug Anxiety	1.0	1.1	2.6	-1.0	-0.9	0.0	-1.6
Baseline Anxiety	5.2	5.5	6.3	2.5	2.4	-2.2	2.2
Tail length	1.1	3.5	5.0	-2.2	-2.1	2.1	-0.5
Length with tail	2.8	10.1	12.5	-3.5	-3.4	3.5	-2.0
Length without tail	2.5	5.5	6.8	-2.2	-2.4	2.6	-2.1
Times rat made contact with spout	2.6	3.0	4.1	-1.8	-1.8	1.2	-2.0
Lifetime Intake	0.1	0.1	0.2	-0.2	-0.3	0.4	0.1
Liver weight, left	0.5	0.8	1.4	-0.8	-0.8	0.9	-1.2
Liver weight, right	2.7	4.5	6.8	-2.2	-2.2	2.6	-1.0
Locomotor activity	0.2	0.4	0.6	0.7	0.6	-0.8	0.3
Locomotor testing distance	0.6	1.0	1.3	1.1	1.1	-1.0	0.9
Locomotor testing rearing	0.7	1.1	1.6	1.1	1.0	-1.3	0.7
Locomotion in novel chamber	0.5	0.6	0.8	0.8	0.8	-0.4	0.9
Locomotion in novel chamber post-restriction	1.1	1.3	1.7	-1.3	-1.2	1.2	-0.8
Fecal boli incidents, locomotor time 1	0.4	0.4	0.6	0.8	0.7	-0.5	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.2	0.1	-0.7	-0.8
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.7	0.5	0.5	-1.3	1.2
Bouts of movement, locomotor time 1	0.7	0.7	1.0	1.0	1.0	-0.9	0.5
Total resting periods, locomotor time 1	0.4	0.4	0.6	0.8	0.8	-0.7	0.2
Rest time, locomotor task time 1	0.3	0.3	0.4	-0.4	-0.4	0.6	-0.7
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	-0.1	0.2	0.3
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.0	0.1	-0.6	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.3	-0.4	0.5	0.3
Bouts of movement, locomotor time 2	1.1	1.2	1.4	1.1	1.2	-1.1	0.9
Total resting periods, locomotor time 2	1.1	1.2	1.3	1.1	1.1	-1.0	1.2
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.1	-0.2	0.6	0.2
Vertical activity count, locomotor time 2	0.4	0.4	1.1	0.5	0.5	-0.5	1.0
Light reinforcement 1	0.1	0.2	0.8	0.1	0.2	-0.2	0.9
Light reinforcement 2	0.5	0.6	1.0	-1.0	-0.9	0.9	0.1
Bone: marrow area	0.5	1.1	1.4	1.0	1.0	-0.9	1.2
Bone: maximum diameter	1.5	2.7	3.6	-1.8	-1.7	1.9	-0.9
Bone: maximum force	2.5	4.4	6.0	-2.5	-2.3	2.0	-1.5
Bone: maximum moment	3.2	5.6	7.5	-2.7	-2.6	2.1	-1.9
Mean time between licks in bursts	0.9	1.2	1.6	1.3	1.3	-0.8	1.0
Mean num. licks in bursts	0.7	0.9	2.2	-0.8	-0.8	0.2	-1.5
Cd content in liver	2.3	2.6	3.3	1.8	1.7	-1.7	1.0
Co content in liver	0.2	0.3	0.6	0.5	0.5	-0.8	0.2
Cu content in liver	2.0	2.4	3.2	-1.6	-1.6	1.0	-1.8
Fe content in liver	0.7	0.8	1.0	1.0	1.0	-0.8	0.8
K content in liver	0.5	0.5	0.9	-0.8	-0.7	0.9	0.2
Mg content in liver	0.9	0.9	2.4	0.7	0.7	-0.5	1.5
Mn content in liver	0.5	0.5	0.7	-0.8	-0.8	0.8	-0.4
Na content in liver	0.2	0.2	0.3	-0.4	-0.4	0.6	-0.1
Rb content in liver	0.1	0.1	0.3	0.1	0.1	-0.5	0.6
Se content in liver	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.0
Sr content in liver	1.3	1.2	2.3	-1.0	-1.0	0.7	-1.5
Zn content in liver	0.6	0.7	1.4	-0.8	-0.8	1.2	-0.3
Bone: minimum diameter	2.4	4.4	5.9	-2.4	-2.3	1.8	-1.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	0.1	-0.4	-0.5
Time in novel zone, hab. session 1	0.0	0.0	0.2	0.1	0.1	0.0	0.4
Total zone transitions, hab. session 1	0.9	1.3	1.5	1.2	1.2	-1.2	0.8
Total locomotion distance, hab. session 1	0.5	0.7	1.1	0.8	0.9	-1.1	0.7
Locomotion velocity, hab. session 1	0.4	0.6	0.7	0.7	0.8	-0.9	0.7
Time in familiar zone, hab. session 2	0.7	0.8	1.0	0.9	0.9	-1.0	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.1	-0.1	0.2	0.2
Total zone transitions, hab. session 2	2.7	3.5	4.0	1.9	1.9	-1.7	2.0
Total locomotion distance, hab. session 2	1.3	1.7	3.0	1.1	1.2	-1.0	1.7
Locomotion velocity, hab. session 2	0.8	1.1	2.3	0.8	0.9	-0.8	1.5
Novel to familiar place preference ratio	2.6	2.7	4.0	-1.8	-1.8	0.6	-2.0
Novelty place preference	2.7	2.8	4.1	-1.8	-1.8	0.6	-2.0
Time in novel zone, NPP test	1.9	1.9	3.0	-1.5	-1.5	0.4	-1.7
Total zone transitions, NPP test	3.4	4.8	6.2	2.2	2.2	-1.8	2.5
Total locomotion distance, NPP test	2.7	3.7	5.5	1.8	1.8	-1.7	2.4
Locomotion velocity, NPP test	1.6	2.2	3.4	1.3	1.4	-1.4	1.8
Intraocular pressure	0.0	0.1	0.2	0.0	0.0	-0.5	0.1
Delta distance traveled before/after self-admin	2.2	2.3	2.9	1.5	1.5	-1.7	1.4
Delta ambulatory time before/after self-admin	2.6	2.9	3.2	1.7	1.6	-1.8	1.6
Parametrial fat weight	0.9	1.8	2.4	-1.6	-1.5	1.4	-0.9
Pavlov. Cond. lever latency	5.0	6.4	8.3	2.5	2.5	-2.9	2.1
Pavlov. Cond. magazine entry latency	4.4	5.7	5.9	-2.4	-2.3	2.3	-2.4
Pavlov. Cond. change in total contacts	1.9	2.0	3.5	-1.4	-1.4	0.9	-1.9
Pavlov. Cond. index score	5.3	6.7	7.7	-2.7	-2.7	2.8	-2.2
Pavlov. Cond. latency score	5.8	7.4	8.8	-2.8	-2.8	3.0	-2.3
Pavlov. Cond. lever contacts	2.7	3.2	4.5	-1.8	-1.8	2.1	-1.3
Pavlov. Cond. magazine entry number	5.3	6.6	7.7	2.6	2.5	-2.4	2.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.6	0.6	-0.8	0.9
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.5	7.2	-2.7	-2.6	2.6	-2.2
Pavlov. Cond. response bias	5.0	6.1	6.3	-2.5	-2.5	2.5	-2.4
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.8	-0.8	1.2	-0.8
Pavlov. Cond. magazine entry latency	4.4	5.1	6.2	2.4	2.3	-2.5	1.8
Pavlov. Cond. change in total contacts	2.1	2.9	4.4	1.7	1.7	-2.1	1.3
Pavlov. Cond. index score	2.2	2.8	4.4	1.6	1.6	-2.1	1.1
Pavlov. Cond. latency score	2.2	2.7	4.0	1.6	1.6	-2.0	1.2
Pavlov. Cond. lever contacts	0.6	0.9	1.4	0.7	0.8	-1.2	0.9
Pavlov. Cond. magazine entry number	4.1	5.0	6.7	-2.3	-2.2	2.6	-1.7
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.1	-1.0	-1.0	1.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.2	5.0	1.8	1.8	-2.2	1.2
Pavlov. Cond. response bias	1.4	2.0	3.1	1.3	1.3	-1.7	1.1
Time in closed arm before self-admin	0.1	0.2	0.6	-0.2	-0.0	-0.1	-0.8
Time in closed arm after self-admin	0.8	0.8	1.1	-0.9	-0.8	0.8	-1.1
Time in open arm before self-admin	0.2	0.2	0.5	-0.1	-0.3	0.5	0.7
Time in open arm after self-admin	0.5	0.6	0.8	0.8	0.7	-0.5	0.9
Bone: periosteal estimation	0.7	1.4	2.2	-1.5	-1.3	1.2	-0.7
Bone: periosteal perimeter	5.0	8.3	9.7	-3.1	-3.0	3.0	-2.4
Bone: post-yield work	0.5	0.6	1.0	0.8	0.8	-0.6	1.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.7	-0.6	0.4	-0.1
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.7	-0.6	0.4	-0.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.7	-0.8	-0.7	0.7	-0.3
Progressive ratio test 2 active lever presses	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.7	-0.7	-0.8	0.8	-0.7
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	-0.4	-0.4	0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.9	-0.3	-0.2	-0.6	-1.4
Progressive ratio	0.2	0.2	0.3	0.5	0.4	-0.5	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.5	-0.0	-0.1	-0.3	-0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.0
Retroperitoneal fat weight	1.3	4.1	6.6	-2.6	-2.3	1.6	-1.4
Reaction time number correct	5.4	7.8	9.9	2.6	2.7	-2.7	3.2
Reaction time mean minus median	0.4	0.6	0.6	-0.8	-0.8	0.8	-0.7
Reaction time mean minus median AUC	0.4	0.5	1.2	-0.7	-0.7	1.1	-0.2
Reaction time num false alarms	0.1	0.2	0.3	0.5	0.5	-0.4	0.2
Reaction time num false alarms AUC	0.4	0.6	0.7	0.8	0.8	-0.7	0.6
Reaction time trials correct on left	5.4	7.8	9.9	2.6	2.7	-2.7	3.2
Reaction time trials on left	5.6	8.0	10.3	2.7	2.7	-2.7	3.2
Reaction time mean	0.0	0.1	0.2	-0.1	-0.0	-0.5	0.1
Reaction time mean AUC	0.1	0.2	0.4	0.2	0.2	-0.6	0.5
Median of all reaction times	0.2	0.2	0.7	0.3	0.3	-0.8	0.4
Reaction time omissions	0.0	0.0	0.2	-0.0	0.0	0.0	0.4
Reaction time false alarm rate	0.4	0.5	1.0	-0.5	-0.5	0.7	-1.0
Reaction time premature initiation rate	0.6	0.9	1.2	1.1	1.0	-1.0	0.4
Reaction time premature initiations	3.7	5.3	5.8	2.4	2.4	-2.4	2.0
Std. dev. reaction times	0.2	0.3	0.4	0.6	0.5	-0.7	0.5
Reaction time trials completed	5.6	8.0	10.3	2.7	2.7	-2.7	3.2
Reaction time trials AUC	5.4	7.8	10.0	2.6	2.6	-2.7	3.2
Run reversals in cocaine runway, females	2.9	2.8	3.2	1.7	1.7	-1.8	1.4
Run reversals in cocaine runway, males	3.0	2.9	3.2	-1.8	-1.8	1.5	-1.7
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.7	0.7	-0.8	0.7
Latency to leave start box in cocaine runway, F	1.1	1.2	1.8	1.0	1.0	-0.9	1.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.3	-0.2	0.0	-0.4
Std. dev. time between licks in bursts	1.9	2.3	4.3	1.2	1.4	-1.3	2.1
Total sessions with >9 infusions	0.1	0.1	0.4	0.2	0.1	-0.2	0.6
Short access day 1 total inactive lever presses	0.4	0.4	1.2	0.3	0.2	0.7	1.1
Short access day 10 total inactive lever presses	1.7	1.9	2.3	-1.5	-1.4	1.2	-1.3
Short access day 1 total infusions	0.4	0.4	0.6	0.8	0.7	-0.5	0.6
Short access day 10 total infusions	0.5	0.5	0.7	-0.8	-0.7	0.8	-0.6
Short access total infusions	0.0	0.0	0.0	-0.0	-0.0	0.0	0.1
Short access day 1 locomotion	0.2	0.2	0.6	-0.3	-0.4	0.7	-0.3
Short access day 10 total locomotion	0.6	0.7	0.9	-0.8	-0.9	0.8	-0.9
Short access total locomotion	0.3	0.3	0.6	-0.4	-0.5	0.8	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.5	-0.5	0.0	-0.1
Compulsive drug intake	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0
One hour access (shock baseline)	0.2	0.2	0.5	-0.3	-0.4	0.7	0.4
Social response proportion	0.8	0.9	1.2	1.0	0.9	-1.1	0.8
Social responses	0.2	0.2	0.3	0.4	0.4	-0.5	0.6
Social time	0.4	0.5	0.9	0.6	0.6	-0.9	0.6
Soleus weight	0.6	1.8	2.7	-1.5	-1.4	1.6	-0.5
Bone: stiffness	0.2	0.4	0.6	-0.7	-0.6	0.8	-0.1
Tibialis anterior weight	0.1	0.4	0.9	0.5	0.5	-0.4	1.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.1	-0.0	0.3	0.2
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.0	0.9	0.8	0.1	1.0
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.5	-0.6	0.3	-0.6
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	0.8	0.6	-0.5	0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	0.1	-0.5	-0.1
Tibia length	9.3	26.1	32.0	-5.7	-5.4	5.0	-4.3
Ambulatory time before self-admin	2.0	2.1	2.7	-1.6	-1.4	1.0	-1.6
Ambulatory time after self-admin	0.1	0.2	0.6	0.1	0.1	-0.8	0.0
Bone: tissue strength	0.1	0.1	0.1	-0.3	-0.3	0.1	0.2
Total heroin consumption	0.6	0.7	1.8	-0.7	-0.7	0.2	-1.3
Bone: trabecular number	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.2
Bone: trabecular spacing	2.3	2.9	3.4	1.6	1.7	-1.7	1.8
Bone: trabecular thickness	2.5	3.0	4.1	-1.7	-1.7	1.4	-2.0
Bone: trabecular tissue density	0.3	0.4	0.7	0.8	0.8	-0.1	0.5
Water consumed over 24 hours	0.6	0.7	1.0	-0.8	-0.8	0.6	-1.0
Number of responses in last shaping day	1.0	1.0	2.2	-1.0	-1.0	1.5	-0.1