LOC120095301

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC120095301 0.04 0.02 7.4e-05 0.02 0.02 0.01 0.01 3.1e-03 2.1e-03 2.8e-02 1.3e-02
2 Adipose gene expression LOC120095301 0.03 0.02 1.0e-03 0.03 0.02 0.01 0.02 3.1e-04 1.9e-03 6.7e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.60.91.1-0.9-1.0
Area under the delay curve0.10.10.20.30.4
BMI with tail0.41.41.6-1.11.3
BMI without tail1.53.16.1-2.50.4
Body weight1.66.812.2-3.5-1.2
Weight adjusted by age1.11.31.31.11.1
Bone surface4.78.39.9-2.6-3.2
Bone volume3.45.75.9-2.3-2.4
Breakpoint value in progressive ratio session0.40.40.9-0.9-0.2
Number of licking bursts0.00.00.10.30.0
Context. condit. distance diff. score0.00.00.0-0.20.1
Locomotion velocity, session 10.40.40.6-0.8-0.5
Locomotion distance, session 10.10.10.1-0.40.2
Locomotion velocity, session 20.70.91.3-1.1-0.6
Locomotion distance, session 20.10.10.2-0.30.4
Locomotion velocity, session 30.91.12.00.41.4
Locomotion distance, session 30.00.00.0-0.00.1
Stereotopy head waving bouts, day 30.81.01.01.01.0
Stereotopy head waving duration, day 30.91.11.31.01.1
Locomotion velocity, session 70.10.10.20.4-0.0
Locomotion distance, session 70.00.00.0-0.1-0.1
Stereotopy head waving bouts, day 71.11.21.80.81.4
Stereotopy head waving duration, day 72.42.93.01.71.7
Locomotion velocity, session 81.11.31.6-1.0-1.2
Locomotion distance, session 80.20.20.5-0.7-0.0
Degree of sensitization distance0.30.30.5-0.3-0.7
Degree of sensitization stereotypy1.41.52.60.71.6
Conditioned locomotion0.30.30.5-0.7-0.3
Cocaine response after cond. corrected1.11.32.51.60.2
Cocaine response after cond. not corrected1.51.73.21.80.4
Cocaine response before conditioning0.20.20.50.10.7
Saline control response1.62.14.1-2.00.1
Bone: connectivity density1.32.12.7-1.2-1.6
Bone: cortical apparent density3.85.06.02.02.5
Bone: cortical area1.62.44.8-2.2-0.3
Bone: cortical porosity4.95.47.7-2.8-1.7
Bone: cortical porosity2.42.64.6-2.2-0.8
Bone: cortical thickness5.28.614.81.53.8
Bone: cortical thickness2.83.35.70.92.4
Bone: cortical tissue density3.64.75.62.02.4
Condit. Reinf. active minus inactive responses2.02.24.2-2.0-0.5
Condit. Reinf. active-inactive response ratio0.60.71.2-1.1-0.4
Condit. Reinf. active responses2.63.25.8-2.4-0.8
Condit. Reinf. inactive responses0.91.01.6-1.3-0.6
Incentive salience index mean1.72.13.8-2.0-0.5
Condit. Reinf. lever presses0.30.40.6-0.80.4
Condit. Reinf. active minus inactive responses3.34.17.1-2.7-1.0
Condit. Reinf. active-inactive response ratio1.31.42.0-1.4-0.9
Condit. Reinf. active responses5.06.911.9-3.5-1.4
Condit. Reinf. inactive responses3.13.87.4-2.7-0.5
Condit. Reinf. lever presses2.23.05.9-2.4-0.2
Condit. Reinf. lever reinforcers received4.15.89.9-3.1-1.3
Conditioned reinforcement - actives0.30.30.5-0.70.2
Conditioned reinforcement - inactives1.82.12.9-1.7-1.1
Conditioned locomotion1.92.33.7-1.9-0.9
Patch foraging indifference point 0 sec4.16.611.3-3.4-1.3
Patch foraging indifference point AUC1.61.92.8-1.7-1.0
Delay disc. indifference point, 0s delay0.91.01.61.20.6
Delay disc. indifference point, 16s delay0.20.20.50.00.7
Delay disc. indifference point, 2s delay0.10.20.30.1-0.5
Delay disc. indifference point, 24s delay0.90.81.7-1.3-0.0
Delay disc. indifference point, 4s delay1.11.11.51.20.9
Delay disc. indifference point, 8s delay0.70.70.70.80.8
Indifference point function ln k0.81.11.80.61.3
Indifference point function log k0.81.11.80.61.3
Patch foraging total patch changes 0 sec4.16.611.0-3.3-1.5
Patch foraging total patch changes 12 sec5.97.69.7-3.1-2.4
Patch foraging total patch changes 18 sec3.24.16.7-2.6-1.2
Patch foraging total patch changes 24 sec3.44.17.1-2.7-1.1
Patch foraging total patch changes 6 sec3.14.67.0-2.6-1.5
Patch foraging time to switch 0 sec0.20.30.70.8-0.0
Patch foraging water rate 0 sec1.72.74.4-2.1-1.0
Patch foraging water rate 12 sec0.91.41.61.11.3
Patch foraging water rate 18 sec0.30.40.70.30.8
Patch foraging water rate 24 sec0.20.20.30.60.4
Patch foraging water rate 6 sec0.30.50.80.40.9
Seeking ratio, delayed vs. immediate footshock0.20.20.3-0.60.2
Distance traveled before self-admin1.01.01.71.30.5
Distance traveled after self-admin0.10.20.20.40.4
Extensor digitorum longus weight0.52.13.31.81.0
Bone: elastic displacement2.22.53.31.31.8
Bone: elastic work0.10.10.2-0.40.4
Bone: endosteal estimation16.034.835.6-5.8-6.0
Bone: endosteal perimeter16.133.333.4-5.8-5.8
Epididymis fat weight0.71.71.7-1.3-1.3
Delta time in closed arm before/after self-admin0.20.20.40.2-0.6
Delta time in open arm before/after self-admin0.70.60.90.70.9
Diff in mean of infusions in LGA sessions0.90.91.40.71.2
Delay discount exponential model param0.00.00.0-0.1-0.1
Extinction: sum of active levers before priming0.20.20.3-0.60.1
Active lever presses in extinction session 61.81.82.9-1.7-0.8
Bone: final force0.71.11.6-1.3-0.7
Bone: final moment0.81.21.8-1.3-0.8
Food consumed during 24 hour testing period2.32.74.3-2.1-1.1
Glucose0.91.31.71.31.0
Heart weight0.50.71.40.31.2
Delay discount hyperbolic model param0.00.00.0-0.2-0.2
Intermittent access intake day 1-15 change1.11.12.1-0.4-1.5
Intermittent access intake escalation0.50.51.0-0.0-1.0
Intermittent access intake escalation 22.32.34.1-0.7-2.0
Intermitt. access day 1 inactive lever presses4.04.37.6-2.8-1.0
Intermitt. access day 15 inactive lever presses2.22.43.7-1.9-1.1
Intermitt. access escalation Index3.12.74.82.20.8
Intermittent access day 1 total infusions0.40.50.8-0.90.5
Intermittent access day 15 total infusions0.30.30.5-0.7-0.4
Intermittent access terminal intake (last 3 days)2.32.52.7-1.7-1.5
Intermittent access total infusions2.12.34.0-2.0-0.9
Intermittent access day 1 locomotion2.42.54.7-2.2-0.6
Intermittent access day 15 total locomotion4.95.37.6-2.8-1.7
Intermittent access total locomotion7.28.213.5-3.7-1.7
Intermittent access standard deviation1.51.62.6-1.6-0.8
Left kidney weight1.33.77.00.72.6
Right kidney weight0.71.93.50.51.9
Cocaine induced anxiety0.30.30.50.40.7
Post-drug Anxiety0.91.01.31.10.8
Baseline Anxiety1.31.41.91.40.9
Tail length1.54.76.3-2.5-1.7
Length with tail1.55.55.7-2.4-2.3
Length without tail0.41.01.8-0.3-1.4
Times rat made contact with spout0.70.80.8-0.9-0.9
Lifetime Intake2.62.95.6-2.4-0.5
Liver weight, left0.50.91.3-0.7-1.1
Liver weight, right0.40.71.11.10.5
Locomotor activity1.42.23.6-1.90.9
Locomotor testing distance2.33.87.0-2.70.8
Locomotor testing rearing2.13.26.3-2.5-0.3
Locomotion in novel chamber0.10.10.20.4-0.2
Locomotion in novel chamber post-restriction1.92.33.7-1.0-1.9
Fecal boli incidents, locomotor time 10.10.20.30.50.0
Change in fecal boli incidents, locomotor task0.00.00.00.20.2
Time >=10cm from walls, locomotor time 11.51.52.51.60.7
Bouts of movement, locomotor time 10.20.20.20.50.5
Total resting periods, locomotor time 10.20.20.40.60.3
Rest time, locomotor task time 10.50.51.01.00.1
Distance moved, locomotor task time 10.70.71.1-1.1-0.6
Vertical activity count, locomotor time 10.30.30.4-0.6-0.5
Time >=10cm from walls, locomotor time 20.20.20.30.6-0.4
Bouts of movement, locomotor time 20.30.30.50.30.7
Total resting periods, locomotor time 20.60.60.90.60.9
Rest time, locomotor task time 25.05.89.13.01.6
Distance moved, locomotor task time 21.21.41.9-1.4-1.0
Vertical activity count, locomotor time 24.04.46.9-2.6-1.4
Light reinforcement 10.71.21.8-0.81.4
Light reinforcement 20.20.30.4-0.60.5
Bone: marrow area15.633.935.1-5.7-5.9
Bone: maximum diameter4.27.69.4-3.1-2.4
Bone: maximum force1.42.54.1-2.0-0.9
Bone: maximum moment1.62.74.3-2.1-1.0
Mean time between licks in bursts0.00.10.1-0.0-0.4
Mean num. licks in bursts0.30.30.5-0.7-0.3
Cd content in liver2.12.34.02.00.7
Co content in liver0.10.10.20.4-0.1
Cu content in liver0.10.10.1-0.3-0.3
Fe content in liver0.20.20.5-0.20.7
K content in liver0.70.71.1-0.6-1.0
Mg content in liver0.40.40.90.1-0.9
Mn content in liver0.00.00.00.10.2
Na content in liver0.20.20.4-0.70.2
Rb content in liver1.41.72.61.60.9
Se content in liver1.61.92.01.41.4
Sr content in liver0.10.10.2-0.4-0.3
Zn content in liver0.20.20.40.60.2
Bone: minimum diameter12.122.727.4-5.2-4.2
Time in familiar zone, hab. session 11.31.31.8-0.8-1.4
Time in novel zone, hab. session 11.31.21.60.91.3
Total zone transitions, hab. session 10.30.40.8-0.90.2
Total locomotion distance, hab. session 10.71.02.0-1.4-0.1
Locomotion velocity, hab. session 10.81.22.2-1.5-0.3
Time in familiar zone, hab. session 22.22.32.5-1.6-1.4
Time in novel zone, hab. session 21.71.72.51.60.9
Total zone transitions, hab. session 20.20.20.4-0.70.2
Total locomotion distance, hab. session 20.50.71.3-1.1-0.3
Locomotion velocity, hab. session 20.40.50.9-1.0-0.2
Novel to familiar place preference ratio0.50.50.6-0.8-0.6
Novelty place preference0.30.30.4-0.6-0.4
Time in novel zone, NPP test0.20.20.3-0.5-0.3
Total zone transitions, NPP test0.50.71.1-0.51.1
Total locomotion distance, NPP test0.50.71.2-1.1-0.3
Locomotion velocity, NPP test0.30.50.9-0.90.2
Intraocular pressure0.40.60.7-0.80.7
Delta distance traveled before/after self-admin0.40.40.8-0.30.9
Delta ambulatory time before/after self-admin0.20.20.3-0.60.3
Parametrial fat weight0.81.73.3-0.2-1.8
Pavlov. Cond. lever latency1.41.73.51.9-0.0
Pavlov. Cond. magazine entry latency2.43.15.5-2.3-0.8
Pavlov. Cond. change in total contacts2.52.75.3-2.3-0.3
Pavlov. Cond. index score2.32.95.5-2.3-0.5
Pavlov. Cond. latency score2.02.54.9-2.2-0.3
Pavlov. Cond. lever contacts1.31.53.0-1.7-0.1
Pavlov. Cond. magazine entry number1.62.03.81.90.5
Pavlov. Cond. intertrial magazine entries1.01.32.5-1.6-0.1
Pavlov. Cond. lever-magazine prob. diff.2.02.44.8-2.2-0.3
Pavlov. Cond. response bias1.92.24.4-2.1-0.3
Pavlov. Cond. lever latency0.30.40.70.9-0.2
Pavlov. Cond. magazine entry latency2.12.53.61.91.1
Pavlov. Cond. change in total contacts0.30.40.8-0.9-0.1
Pavlov. Cond. index score0.10.10.2-0.00.5
Pavlov. Cond. latency score0.20.20.40.20.6
Pavlov. Cond. lever contacts0.30.40.8-0.90.3
Pavlov. Cond. magazine entry number2.93.64.6-2.1-1.6
Pavlov. Cond. intertrial magazine entries12.516.418.5-4.3-3.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.20.5
Pavlov. Cond. response bias0.00.10.1-0.20.3
Time in closed arm before self-admin0.80.91.70.41.3
Time in closed arm after self-admin0.30.30.50.7-0.2
Time in open arm before self-admin0.60.61.21.10.1
Time in open arm after self-admin0.00.00.00.20.1
Bone: periosteal estimation9.619.924.5-5.0-3.9
Bone: periosteal perimeter4.06.78.5-2.9-2.2
Bone: post-yield work2.93.94.1-1.9-2.0
Progressive ratio test 1 active lever presses3.03.15.9-2.4-0.6
Progressive ratio test 1 breakpoint3.94.17.9-2.8-0.5
Progressive ratio test 1 inactive lever presses3.94.38.3-2.9-0.6
Progressive ratio test 2 active lever presses3.13.45.1-2.3-1.3
Progressive ratio test 2 breakpoint3.74.25.9-2.4-1.6
Progressive ratio test 2 inactive lever presses3.54.06.5-2.5-1.2
Incentive Sensitization - Responses2.42.42.8-1.4-1.7
Incentive Sensitization - Breakpoint2.42.43.0-1.4-1.7
Sum of active levers in priming session hrs 5-60.90.91.60.41.2
Progressive ratio0.50.60.70.9-0.6
Food seeking constrained by brief footshock5.16.37.3-2.3-2.7
Seeking ratio, punishment vs. effort2.12.54.3-2.1-0.9
Retroperitoneal fat weight1.96.36.3-2.5-2.5
Reaction time number correct1.72.43.01.71.4
Reaction time mean minus median0.20.20.50.7-0.1
Reaction time mean minus median AUC0.81.11.71.30.7
Reaction time num false alarms2.33.15.6-2.4-0.8
Reaction time num false alarms AUC2.53.55.7-2.4-1.1
Reaction time trials correct on left1.72.43.01.71.4
Reaction time trials on left1.62.32.91.71.3
Reaction time mean0.40.51.01.00.3
Reaction time mean AUC0.50.71.21.10.4
Median of all reaction times0.30.40.70.90.3
Reaction time omissions0.20.30.60.3-0.8
Reaction time false alarm rate3.75.27.9-2.8-1.6
Reaction time premature initiation rate0.91.22.4-1.5-0.0
Reaction time premature initiations0.20.30.3-0.50.6
Std. dev. reaction times0.40.50.60.8-0.6
Reaction time trials completed1.62.32.91.71.3
Reaction time trials AUC1.52.22.91.71.2
Run reversals in cocaine runway, females0.30.30.60.7-0.0
Run reversals in cocaine runway, males0.20.20.30.50.3
Latency to leave start box in cocaine runway0.30.30.40.50.6
Latency to leave start box in cocaine runway, F1.11.22.00.71.4
Latency to leave start box in cocaine runway, M0.30.30.50.2-0.7
Std. dev. time between licks in bursts0.00.00.0-0.1-0.0
Total sessions with >9 infusions1.61.83.3-0.61.8
Short access day 1 total inactive lever presses0.80.81.6-1.3-0.2
Short access day 10 total inactive lever presses1.21.31.7-1.3-1.0
Short access day 1 total infusions2.02.22.2-1.51.5
Short access day 10 total infusions5.46.010.5-3.2-1.2
Short access total infusions3.23.67.2-2.70.1
Short access day 1 locomotion2.93.16.1-2.50.4
Short access day 10 total locomotion9.710.818.0-4.2-1.9
Short access total locomotion5.15.310.6-3.3-0.2
One hour access (0.3 mA shock)1.01.11.6-1.3-0.8
Compulsive drug intake1.11.11.91.40.6
One hour access (shock baseline)1.61.82.9-1.7-0.8
Social response proportion0.40.40.50.50.7
Social responses0.30.40.6-0.70.5
Social time0.10.10.20.5-0.2
Soleus weight0.20.70.9-0.70.9
Bone: stiffness0.91.42.0-1.4-0.9
Tibialis anterior weight0.20.71.2-1.1-0.3
Time to tail flick, vehicle, before self-admin0.90.91.51.2-0.6
Time to tail flick, vehicle, after self-admin0.20.20.4-0.1-0.6
Time to tail flick, test, before self-admin0.70.71.11.0-0.4
Time to tail flick, test, after self-admin0.30.30.40.50.6
Delta time to tail flick, vehicle, before/after SA2.02.02.4-1.5-1.3
Delta time to tail flick, test, before/after SA0.10.10.20.00.4
Tibia length0.30.81.60.31.3
Ambulatory time before self-admin0.50.50.91.00.3
Ambulatory time after self-admin0.10.10.1-0.10.3
Bone: tissue strength1.51.51.51.21.2
Total heroin consumption0.10.20.3-0.50.2
Bone: trabecular number0.91.51.6-1.2-1.2
Bone: trabecular spacing0.20.20.20.50.4
Bone: trabecular thickness1.11.31.5-1.2-1.0
Bone: trabecular tissue density1.42.02.21.41.5
Water consumed over 24 hours0.10.10.2-0.50.1
Number of responses in last shaping day0.60.61.0-1.00.5