Hub : Genes

LOC120095206

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC120095206 0.04 0.02 3.4e-05 0.03 0.03 0.03 0.03 5.8e-04 3.5e-04 5.8e-04 3.9e-04
2 Liver gene expression LOC120095206 0.06 0.03 4.5e-04 0.04 0.03 0.03 0.02 5.4e-05 7.8e-04 6.5e-04 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.32.33.51.9-1.0
Area under the delay curve0.10.10.20.0-0.5
BMI with tail0.93.13.1-1.81.8
BMI without tail1.64.99.3-3.00.7
Body weight0.72.94.3-2.11.2
Weight adjusted by age1.32.03.2-0.91.8
Bone surface5.39.719.04.4-0.6
Bone volume3.66.512.43.5-0.8
Breakpoint value in progressive ratio session0.40.50.90.90.4
Number of licking bursts0.40.70.90.90.7
Context. condit. distance diff. score0.40.51.0-1.00.0
Locomotion velocity, session 10.70.81.20.61.1
Locomotion distance, session 10.10.20.3-0.60.0
Locomotion velocity, session 20.00.00.0-0.2-0.1
Locomotion distance, session 20.00.00.10.30.0
Locomotion velocity, session 32.32.65.2-0.12.3
Locomotion distance, session 32.42.64.50.82.1
Stereotopy head waving bouts, day 30.20.30.40.40.6
Stereotopy head waving duration, day 30.30.40.50.50.7
Locomotion velocity, session 70.50.61.21.10.1
Locomotion distance, session 70.70.91.10.91.1
Stereotopy head waving bouts, day 70.10.10.20.5-0.1
Stereotopy head waving duration, day 70.50.50.91.00.4
Locomotion velocity, session 80.30.40.70.30.8
Locomotion distance, session 80.10.10.2-0.50.1
Degree of sensitization distance0.80.81.6-0.1-1.3
Degree of sensitization stereotypy0.00.00.0-0.1-0.2
Conditioned locomotion0.50.61.2-0.01.1
Cocaine response after cond. corrected0.10.10.10.0-0.4
Cocaine response after cond. not corrected0.00.00.00.1-0.1
Cocaine response before conditioning0.40.40.90.00.9
Saline control response1.31.83.6-1.90.0
Bone: connectivity density1.92.95.82.4-0.1
Bone: cortical apparent density2.43.36.7-2.6-0.2
Bone: cortical area0.20.20.40.4-0.6
Bone: cortical porosity2.42.65.10.4-2.3
Bone: cortical porosity0.91.01.60.5-1.3
Bone: cortical thickness7.111.821.4-4.6-1.5
Bone: cortical thickness0.91.11.7-1.30.7
Bone: cortical tissue density2.43.26.4-2.5-0.1
Condit. Reinf. active minus inactive responses0.10.10.3-0.50.0
Condit. Reinf. active-inactive response ratio0.00.00.00.20.2
Condit. Reinf. active responses0.20.30.6-0.80.1
Condit. Reinf. inactive responses0.10.20.3-0.50.1
Incentive salience index mean0.00.10.1-0.30.1
Condit. Reinf. lever presses0.20.30.7-0.8-0.0
Condit. Reinf. active minus inactive responses0.00.00.00.10.1
Condit. Reinf. active-inactive response ratio0.20.20.3-0.5-0.2
Condit. Reinf. active responses0.10.10.10.40.1
Condit. Reinf. inactive responses0.20.30.30.60.5
Condit. Reinf. lever presses1.31.93.5-0.4-1.9
Condit. Reinf. lever reinforcers received0.00.10.10.30.0
Conditioned reinforcement - actives0.30.60.70.8-0.7
Conditioned reinforcement - inactives0.40.50.8-0.5-0.9
Conditioned locomotion0.40.50.7-0.6-0.8
Patch foraging indifference point 0 sec2.95.46.9-2.6-2.0
Patch foraging indifference point AUC0.50.71.1-1.1-0.5
Delay disc. indifference point, 0s delay0.10.20.3-0.5-0.1
Delay disc. indifference point, 16s delay0.20.20.40.6-0.3
Delay disc. indifference point, 2s delay0.10.10.2-0.0-0.4
Delay disc. indifference point, 24s delay0.60.60.70.9-0.7
Delay disc. indifference point, 4s delay0.10.10.1-0.40.2
Delay disc. indifference point, 8s delay0.00.10.1-0.3-0.0
Indifference point function ln k0.10.10.2-0.0-0.4
Indifference point function log k0.10.10.2-0.0-0.4
Patch foraging total patch changes 0 sec2.64.96.6-2.6-1.8
Patch foraging total patch changes 12 sec1.82.43.4-1.9-1.1
Patch foraging total patch changes 18 sec3.45.38.2-2.9-1.5
Patch foraging total patch changes 24 sec0.81.41.5-1.2-1.2
Patch foraging total patch changes 6 sec4.87.311.4-3.4-1.8
Patch foraging time to switch 0 sec0.71.51.91.41.0
Patch foraging water rate 0 sec1.83.86.8-2.6-0.9
Patch foraging water rate 12 sec0.61.32.3-1.5-0.6
Patch foraging water rate 18 sec0.50.71.0-1.00.6
Patch foraging water rate 24 sec1.92.74.3-1.1-2.1
Patch foraging water rate 6 sec0.71.11.9-1.4-0.5
Seeking ratio, delayed vs. immediate footshock1.41.72.9-1.7-0.7
Distance traveled before self-admin0.60.81.5-1.20.0
Distance traveled after self-admin0.50.71.3-1.10.2
Extensor digitorum longus weight0.10.61.10.11.1
Bone: elastic displacement1.51.73.0-1.70.7
Bone: elastic work0.30.40.7-0.90.2
Bone: endosteal estimation10.523.045.36.70.8
Bone: endosteal perimeter9.620.440.56.40.6
Epididymis fat weight1.34.59.1-3.00.1
Delta time in closed arm before/after self-admin0.00.00.00.2-0.2
Delta time in open arm before/after self-admin0.40.40.80.90.1
Diff in mean of infusions in LGA sessions0.60.71.4-1.20.1
Delay discount exponential model param0.10.20.30.00.5
Extinction: sum of active levers before priming0.91.01.91.40.3
Active lever presses in extinction session 61.41.42.81.70.1
Bone: final force1.01.63.31.8-0.0
Bone: final moment0.61.02.01.4-0.3
Food consumed during 24 hour testing period1.62.24.3-0.4-2.1
Glucose0.30.50.80.40.9
Heart weight2.74.14.4-2.1-2.0
Delay discount hyperbolic model param0.10.10.3-0.00.5
Intermittent access intake day 1-15 change0.91.92.7-1.1-1.6
Intermittent access intake escalation1.02.02.2-1.3-1.5
Intermittent access intake escalation 23.74.26.1-1.5-2.5
Intermitt. access day 1 inactive lever presses0.20.61.1-1.1-0.2
Intermitt. access day 15 inactive lever presses0.10.20.3-0.50.3
Intermitt. access escalation Index0.10.20.3-0.6-0.2
Intermittent access day 1 total infusions0.71.11.70.81.3
Intermittent access day 15 total infusions0.20.30.5-0.30.7
Intermittent access terminal intake (last 3 days)0.00.00.00.1-0.1
Intermittent access total infusions1.21.42.50.51.6
Intermittent access day 1 locomotion0.10.10.2-0.5-0.2
Intermittent access day 15 total locomotion1.01.83.5-1.9-0.1
Intermittent access total locomotion0.70.81.7-1.30.2
Intermittent access standard deviation0.40.91.7-0.21.3
Left kidney weight0.00.00.10.3-0.0
Right kidney weight0.00.10.10.3-0.2
Cocaine induced anxiety0.00.00.0-0.0-0.0
Post-drug Anxiety0.00.00.10.2-0.2
Baseline Anxiety0.20.20.40.1-0.6
Tail length0.93.74.6-2.2-1.6
Length with tail0.41.92.1-1.3-1.5
Length without tail0.10.30.50.30.7
Times rat made contact with spout1.31.52.2-1.5-0.8
Lifetime Intake0.70.81.50.51.2
Liver weight, left0.20.40.70.80.3
Liver weight, right0.20.30.7-0.00.8
Locomotor activity0.30.50.7-0.9-0.6
Locomotor testing distance1.01.83.1-1.8-0.7
Locomotor testing rearing4.38.615.4-3.9-1.3
Locomotion in novel chamber0.20.30.30.5-0.6
Locomotion in novel chamber post-restriction0.71.22.2-0.4-1.5
Fecal boli incidents, locomotor time 10.71.11.11.0-1.0
Change in fecal boli incidents, locomotor task1.21.11.2-1.0-1.1
Time >=10cm from walls, locomotor time 10.91.01.81.30.4
Bouts of movement, locomotor time 11.71.92.5-1.6-1.1
Total resting periods, locomotor time 11.01.11.1-1.0-1.1
Rest time, locomotor task time 11.11.42.8-0.3-1.7
Distance moved, locomotor task time 12.53.77.40.12.7
Vertical activity count, locomotor time 10.71.83.6-0.11.9
Time >=10cm from walls, locomotor time 20.81.11.8-1.3-0.7
Bouts of movement, locomotor time 20.60.91.0-0.9-1.0
Total resting periods, locomotor time 20.71.31.7-1.0-1.3
Rest time, locomotor task time 21.01.31.51.2-1.0
Distance moved, locomotor task time 22.42.95.3-0.72.3
Vertical activity count, locomotor time 20.81.11.3-1.01.1
Light reinforcement 10.00.00.00.2-0.1
Light reinforcement 21.72.74.22.11.0
Bone: marrow area10.322.544.26.70.8
Bone: maximum diameter5.510.320.74.5-0.1
Bone: maximum force1.62.84.42.1-1.1
Bone: maximum moment1.32.32.61.6-1.4
Mean time between licks in bursts0.10.10.20.50.3
Mean num. licks in bursts0.81.21.7-1.3-0.9
Cd content in liver0.30.30.6-0.80.2
Co content in liver1.51.72.3-1.5-1.1
Cu content in liver0.10.10.20.4-0.1
Fe content in liver0.30.40.8-0.20.9
K content in liver1.31.22.41.60.0
Mg content in liver0.80.80.90.9-1.0
Mn content in liver0.91.01.71.3-0.5
Na content in liver1.01.11.40.8-1.2
Rb content in liver0.91.02.00.11.4
Se content in liver0.20.30.40.4-0.6
Sr content in liver0.50.40.6-0.8-0.5
Zn content in liver0.60.61.21.10.0
Bone: minimum diameter5.49.818.94.3-0.8
Time in familiar zone, hab. session 14.13.97.6-0.5-2.8
Time in novel zone, hab. session 12.22.24.30.32.1
Total zone transitions, hab. session 10.40.50.6-0.8-0.7
Total locomotion distance, hab. session 10.60.90.9-0.9-1.0
Locomotion velocity, hab. session 10.10.20.3-0.50.0
Time in familiar zone, hab. session 21.01.11.1-1.0-1.1
Time in novel zone, hab. session 23.33.34.22.01.6
Total zone transitions, hab. session 20.10.10.1-0.3-0.2
Total locomotion distance, hab. session 20.20.20.5-0.7-0.0
Locomotion velocity, hab. session 20.10.20.3-0.6-0.0
Novel to familiar place preference ratio0.10.20.2-0.4-0.4
Novelty place preference0.00.00.1-0.2-0.2
Time in novel zone, NPP test0.10.10.1-0.3-0.2
Total zone transitions, NPP test0.20.30.5-0.70.3
Total locomotion distance, NPP test0.60.81.4-1.2-0.3
Locomotion velocity, NPP test0.60.81.6-1.3-0.2
Intraocular pressure0.00.10.10.10.4
Delta distance traveled before/after self-admin0.10.10.1-0.30.1
Delta ambulatory time before/after self-admin0.00.00.00.10.1
Parametrial fat weight1.12.75.22.3-0.4
Pavlov. Cond. lever latency1.82.34.52.1-0.1
Pavlov. Cond. magazine entry latency1.21.52.6-1.6-0.6
Pavlov. Cond. change in total contacts2.82.94.4-2.1-1.2
Pavlov. Cond. index score1.11.42.8-1.7-0.2
Pavlov. Cond. latency score1.31.63.1-1.8-0.3
Pavlov. Cond. lever contacts1.72.03.8-2.0-0.4
Pavlov. Cond. magazine entry number0.91.22.21.50.4
Pavlov. Cond. intertrial magazine entries0.30.30.6-0.30.8
Pavlov. Cond. lever-magazine prob. diff.0.81.01.9-1.40.0
Pavlov. Cond. response bias1.11.32.5-1.6-0.4
Pavlov. Cond. lever latency0.30.40.5-0.70.6
Pavlov. Cond. magazine entry latency0.40.50.80.3-0.9
Pavlov. Cond. change in total contacts0.71.01.80.6-1.3
Pavlov. Cond. index score0.60.81.10.7-1.0
Pavlov. Cond. latency score0.50.70.70.8-0.8
Pavlov. Cond. lever contacts0.30.40.50.5-0.7
Pavlov. Cond. magazine entry number0.30.30.6-0.10.8
Pavlov. Cond. intertrial magazine entries1.01.63.01.70.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.20.7-1.1
Pavlov. Cond. response bias0.50.60.90.6-1.0
Time in closed arm before self-admin0.00.10.1-0.30.2
Time in closed arm after self-admin0.70.71.4-1.2-0.2
Time in open arm before self-admin0.20.30.4-0.6-0.4
Time in open arm after self-admin0.30.30.60.8-0.0
Bone: periosteal estimation5.511.523.04.80.2
Bone: periosteal perimeter3.56.012.13.5-0.1
Bone: post-yield work1.72.54.32.1-0.9
Progressive ratio test 1 active lever presses0.81.01.6-1.30.7
Progressive ratio test 1 breakpoint0.70.81.3-1.10.6
Progressive ratio test 1 inactive lever presses0.50.81.4-1.2-0.4
Progressive ratio test 2 active lever presses0.40.40.5-0.60.7
Progressive ratio test 2 breakpoint0.40.50.6-0.70.7
Progressive ratio test 2 inactive lever presses0.20.20.5-0.7-0.1
Incentive Sensitization - Responses0.00.00.1-0.30.1
Incentive Sensitization - Breakpoint0.00.00.1-0.30.1
Sum of active levers in priming session hrs 5-60.20.20.3-0.6-0.0
Progressive ratio0.91.42.81.7-0.2
Food seeking constrained by brief footshock0.40.50.9-0.3-0.9
Seeking ratio, punishment vs. effort1.01.42.6-1.6-0.4
Retroperitoneal fat weight0.73.15.6-2.40.8
Reaction time number correct0.71.41.41.2-1.2
Reaction time mean minus median0.40.91.50.6-1.2
Reaction time mean minus median AUC0.92.34.22.1-0.6
Reaction time num false alarms0.40.61.21.1-0.1
Reaction time num false alarms AUC1.01.63.01.7-0.4
Reaction time trials correct on left0.71.41.41.2-1.2
Reaction time trials on left0.81.61.61.3-1.2
Reaction time mean0.00.00.0-0.0-0.1
Reaction time mean AUC0.00.00.00.1-0.0
Median of all reaction times0.00.00.1-0.10.3
Reaction time omissions1.82.62.81.7-1.6
Reaction time false alarm rate0.10.20.40.6-0.0
Reaction time premature initiation rate2.23.06.1-2.5-0.0
Reaction time premature initiations0.40.71.2-1.1-0.5
Std. dev. reaction times0.30.60.60.8-0.8
Reaction time trials completed0.81.61.61.3-1.2
Reaction time trials AUC0.71.41.41.2-1.2
Run reversals in cocaine runway, females1.31.32.2-1.50.7
Run reversals in cocaine runway, males1.61.62.90.51.7
Latency to leave start box in cocaine runway0.80.91.8-0.11.3
Latency to leave start box in cocaine runway, F1.92.23.6-0.91.9
Latency to leave start box in cocaine runway, M0.30.30.60.8-0.1
Std. dev. time between licks in bursts0.50.70.8-0.9-0.8
Total sessions with >9 infusions0.20.20.3-0.50.4
Short access day 1 total inactive lever presses0.50.71.2-0.41.1
Short access day 10 total inactive lever presses0.10.10.2-0.1-0.5
Short access day 1 total infusions0.30.30.6-0.30.7
Short access day 10 total infusions0.30.40.8-0.20.9
Short access total infusions0.20.20.40.10.6
Short access day 1 locomotion2.32.84.4-2.11.1
Short access day 10 total locomotion0.10.20.4-0.60.0
Short access total locomotion0.70.81.4-1.20.5
One hour access (0.3 mA shock)0.10.10.10.3-0.1
Compulsive drug intake0.10.20.30.60.2
One hour access (shock baseline)0.30.40.60.80.5
Social response proportion1.21.31.81.40.9
Social responses0.00.00.1-0.1-0.3
Social time0.40.51.01.00.0
Soleus weight0.31.02.01.4-0.1
Bone: stiffness1.93.05.12.2-1.0
Tibialis anterior weight0.10.40.80.9-0.2
Time to tail flick, vehicle, before self-admin0.20.20.2-0.5-0.5
Time to tail flick, vehicle, after self-admin0.30.40.80.90.3
Time to tail flick, test, before self-admin0.20.20.5-0.70.1
Time to tail flick, test, after self-admin0.20.20.3-0.3-0.6
Delta time to tail flick, vehicle, before/after SA1.00.91.41.20.7
Delta time to tail flick, test, before/after SA0.10.10.20.3-0.4
Tibia length0.41.01.7-0.61.3
Ambulatory time before self-admin0.40.71.3-1.10.1
Ambulatory time after self-admin0.50.61.1-1.10.1
Bone: tissue strength0.80.81.1-1.0-0.7
Total heroin consumption1.92.34.12.00.7
Bone: trabecular number1.62.75.32.30.2
Bone: trabecular spacing2.63.56.5-2.5-0.7
Bone: trabecular thickness1.01.32.51.6-0.2
Bone: trabecular tissue density1.82.63.5-1.3-1.9
Water consumed over 24 hours0.00.00.00.0-0.2
Number of responses in last shaping day0.80.81.6-1.30.2