LOC120095206

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC120095206 0.03 0.02 6.0e-04 0.01 0.01 0.01 0.01 3.4e-02 4.5e-02 5.7e-02 3.5e-02
2 Liver gene expression LOC120095206 0.07 0.03 1.3e-04 0.02 0.04 0.01 0.02 1.1e-03 8.4e-05 1.9e-02 1.5e-03
3 NAcc gene expression LOC120095206 0.06 0.04 6.0e-03 0.03 0 0.03 0.03 6.5e-04 3.0e-01 1.7e-04 2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.01.62.6-1.5-1.60.2
Area under the delay curve0.91.01.7-1.1-1.3-0.1
BMI with tail1.03.25.12.32.00.8
BMI without tail0.30.61.40.70.01.2
Body weight0.52.02.91.61.70.8
Weight adjusted by age2.73.06.11.62.50.7
Bone surface3.56.218.2-4.3-0.40.3
Bone volume2.74.612.3-3.5-0.80.9
Breakpoint value in progressive ratio session0.30.30.8-0.30.90.1
Number of licking bursts0.50.61.5-0.31.20.3
Context. condit. distance diff. score0.60.81.31.20.21.0
Locomotion velocity, session 10.50.51.50.01.2-0.0
Locomotion distance, session 10.81.12.31.50.9-0.0
Locomotion velocity, session 20.10.20.30.2-0.6-0.4
Locomotion distance, session 20.20.20.40.50.60.1
Locomotion velocity, session 31.11.32.90.71.7-0.6
Locomotion distance, session 30.40.40.7-0.60.9-0.3
Stereotopy head waving bouts, day 30.20.30.8-0.10.90.2
Stereotopy head waving duration, day 30.40.41.0-0.31.0-0.5
Locomotion velocity, session 70.50.61.6-1.30.1-0.3
Locomotion distance, session 70.40.61.0-1.00.50.6
Stereotopy head waving bouts, day 71.51.62.50.81.3-1.6
Stereotopy head waving duration, day 71.61.93.60.21.4-1.9
Locomotion velocity, session 80.10.20.4-0.60.30.0
Locomotion distance, session 80.60.81.11.00.70.9
Degree of sensitization distance0.20.20.3-0.4-0.50.3
Degree of sensitization stereotypy1.51.62.51.11.0-1.6
Conditioned locomotion0.60.72.20.20.01.5
Cocaine response after cond. corrected0.70.82.2-0.2-0.51.5
Cocaine response after cond. not corrected0.30.30.8-0.3-0.00.9
Cocaine response before conditioning0.70.81.4-0.11.2-1.0
Saline control response0.91.22.30.8-0.91.5
Bone: connectivity density0.91.43.4-1.9-0.80.2
Bone: cortical apparent density4.25.514.93.91.0-0.8
Bone: cortical area0.81.31.90.51.31.4
Bone: cortical porosity1.01.12.3-1.5-0.9-0.3
Bone: cortical porosity1.11.22.5-1.6-1.10.1
Bone: cortical thickness6.110.030.05.5-0.1-0.3
Bone: cortical thickness1.72.04.32.10.80.9
Bone: cortical tissue density4.05.314.53.81.0-0.7
Condit. Reinf. active minus inactive responses0.91.01.21.11.00.8
Condit. Reinf. active-inactive response ratio0.30.30.50.30.70.6
Condit. Reinf. active responses1.01.21.91.41.10.6
Condit. Reinf. inactive responses0.60.71.21.10.80.5
Incentive salience index mean0.60.71.21.11.00.2
Condit. Reinf. lever presses0.50.61.71.30.1-0.5
Condit. Reinf. active minus inactive responses0.10.10.3-0.10.50.3
Condit. Reinf. active-inactive response ratio0.20.20.40.60.3-0.3
Condit. Reinf. active responses0.20.20.4-0.40.40.6
Condit. Reinf. inactive responses0.20.20.3-0.40.40.6
Condit. Reinf. lever presses0.30.40.70.2-0.70.8
Condit. Reinf. lever reinforcers received0.30.40.7-0.40.40.9
Conditioned reinforcement - actives0.90.92.7-1.7-0.3-0.1
Conditioned reinforcement - inactives0.00.10.2-0.0-0.4-0.0
Conditioned locomotion0.10.10.2-0.4-0.50.1
Patch foraging indifference point 0 sec1.01.62.51.5-1.60.2
Patch foraging indifference point AUC0.20.20.40.3-0.60.3
Delay disc. indifference point, 0s delay0.10.10.30.5-0.2-0.3
Delay disc. indifference point, 16s delay0.60.61.2-1.1-0.7-0.4
Delay disc. indifference point, 2s delay0.60.71.3-0.8-1.1-0.2
Delay disc. indifference point, 24s delay1.31.22.3-1.5-1.20.1
Delay disc. indifference point, 4s delay0.10.10.2-0.3-0.40.2
Delay disc. indifference point, 8s delay0.40.51.1-0.5-1.1-0.1
Indifference point function ln k0.30.40.50.70.7-0.2
Indifference point function log k0.30.40.50.70.7-0.2
Patch foraging total patch changes 0 sec1.01.62.21.5-1.50.6
Patch foraging total patch changes 12 sec1.21.62.40.9-1.51.2
Patch foraging total patch changes 18 sec1.82.33.51.9-1.80.4
Patch foraging total patch changes 24 sec0.60.71.00.6-0.81.0
Patch foraging total patch changes 6 sec1.72.54.72.2-1.7-0.2
Patch foraging time to switch 0 sec0.30.51.4-1.2-0.1-0.2
Patch foraging water rate 0 sec1.82.97.42.70.21.1
Patch foraging water rate 12 sec1.32.04.12.01.30.5
Patch foraging water rate 18 sec1.62.14.02.01.5-0.1
Patch foraging water rate 24 sec0.81.12.20.6-1.50.8
Patch foraging water rate 6 sec1.42.05.22.30.90.2
Seeking ratio, delayed vs. immediate footshock0.40.40.40.7-0.6-0.6
Distance traveled before self-admin0.10.10.30.6-0.10.1
Distance traveled after self-admin0.10.10.20.40.00.1
Extensor digitorum longus weight0.10.30.3-0.50.5-0.6
Bone: elastic displacement2.32.66.62.60.4-1.0
Bone: elastic work1.01.33.41.80.50.5
Bone: endosteal estimation9.420.448.9-7.02.12.8
Bone: endosteal perimeter8.016.537.9-6.22.52.3
Epididymis fat weight0.30.61.71.30.20.2
Delta time in closed arm before/after self-admin0.10.00.10.1-0.30.2
Delta time in open arm before/after self-admin0.30.30.7-0.90.1-0.1
Diff in mean of infusions in LGA sessions0.30.40.70.80.70.1
Delay discount exponential model param1.11.12.01.11.4-0.0
Extinction: sum of active levers before priming0.60.61.1-1.00.8-0.1
Active lever presses in extinction session 60.10.10.2-0.40.30.2
Bone: final force1.01.72.5-1.01.21.6
Bone: final moment0.61.01.4-0.81.01.2
Food consumed during 24 hour testing period0.50.61.50.3-1.20.4
Glucose0.50.81.6-0.20.81.3
Heart weight0.81.22.91.7-0.10.8
Delay discount hyperbolic model param1.01.01.91.11.40.0
Intermittent access intake day 1-15 change0.00.00.1-0.1-0.4-0.0
Intermittent access intake escalation0.10.10.3-0.1-0.5-0.0
Intermittent access intake escalation 20.60.61.8-0.1-1.4-0.0
Intermitt. access day 1 inactive lever presses0.70.82.31.50.30.0
Intermitt. access day 15 inactive lever presses0.30.30.90.90.3-0.0
Intermitt. access escalation Index0.00.00.10.3-0.0-0.1
Intermittent access day 1 total infusions0.40.40.9-1.00.6-0.0
Intermittent access day 15 total infusions0.20.20.4-0.60.5-0.1
Intermittent access terminal intake (last 3 days)0.30.41.1-1.10.0-0.0
Intermittent access total infusions0.30.40.7-0.70.80.0
Intermittent access day 1 locomotion0.20.20.40.70.30.1
Intermittent access day 15 total locomotion0.40.51.41.2-0.10.1
Intermittent access total locomotion0.40.40.91.00.60.1
Intermittent access standard deviation0.20.20.5-0.7-0.10.1
Left kidney weight0.10.20.5-0.7-0.30.0
Right kidney weight0.10.20.4-0.40.20.6
Cocaine induced anxiety0.30.30.91.0-0.0-0.0
Post-drug Anxiety0.00.00.10.2-0.30.0
Baseline Anxiety0.30.30.7-0.9-0.20.1
Tail length0.20.71.5-0.7-1.20.3
Length with tail0.00.10.2-0.1-0.50.1
Length without tail0.30.61.30.81.1-0.2
Times rat made contact with spout1.31.52.11.5-0.8-1.3
Lifetime Intake0.40.40.8-0.90.70.0
Liver weight, left1.11.83.6-1.90.61.3
Liver weight, right0.71.22.3-1.2-0.21.5
Locomotor activity1.21.82.71.31.01.7
Locomotor testing distance2.33.96.22.51.81.5
Locomotor testing rearing3.96.015.43.90.21.6
Locomotion in novel chamber0.10.10.1-0.3-0.1-0.3
Locomotion in novel chamber post-restriction1.11.33.4-0.3-1.8-0.7
Fecal boli incidents, locomotor time 12.93.24.6-2.1-2.1-0.7
Change in fecal boli incidents, locomotor task1.51.43.61.9-0.7-0.4
Time >=10cm from walls, locomotor time 10.80.82.2-1.50.4-0.4
Bouts of movement, locomotor time 10.60.61.20.7-1.1-0.4
Total resting periods, locomotor time 10.60.71.9-0.1-1.4-0.3
Rest time, locomotor task time 11.61.73.9-0.1-2.0-1.2
Distance moved, locomotor task time 13.03.38.50.82.90.9
Vertical activity count, locomotor time 12.93.07.71.02.80.6
Time >=10cm from walls, locomotor time 21.41.43.92.00.2-0.6
Bouts of movement, locomotor time 20.40.41.3-0.0-1.1-0.3
Total resting periods, locomotor time 20.80.82.4-0.1-1.6-0.3
Rest time, locomotor task time 22.02.33.7-1.8-1.9-0.3
Distance moved, locomotor task time 23.54.08.81.83.00.4
Vertical activity count, locomotor time 21.71.93.71.41.9-0.3
Light reinforcement 10.61.12.70.10.71.7
Light reinforcement 21.92.53.8-1.62.01.1
Bone: marrow area9.320.147.3-6.92.22.9
Bone: maximum diameter4.27.614.0-3.72.12.1
Bone: maximum force1.42.44.3-1.60.72.1
Bone: maximum moment0.91.52.8-1.30.41.7
Mean time between licks in bursts0.91.32.9-0.11.0-1.7
Mean num. licks in bursts0.81.01.80.9-1.3-0.7
Cd content in liver0.20.20.40.4-0.00.6
Co content in liver1.82.14.92.20.1-1.2
Cu content in liver0.70.81.4-1.2-0.21.0
Fe content in liver0.30.40.8-0.3-0.4-0.9
K content in liver1.61.63.5-1.90.51.1
Mg content in liver1.31.32.2-1.20.51.5
Mn content in liver1.21.33.5-1.9-0.60.4
Na content in liver1.31.43.3-1.8-0.40.9
Rb content in liver0.70.82.1-0.40.41.5
Se content in liver2.12.66.1-1.1-0.72.5
Sr content in liver1.61.42.40.8-1.1-1.6
Zn content in liver0.40.51.3-1.10.30.3
Bone: minimum diameter4.68.613.8-3.72.32.6
Time in familiar zone, hab. session 11.31.23.6-0.2-1.9-0.3
Time in novel zone, hab. session 11.81.74.20.62.00.8
Total zone transitions, hab. session 10.50.71.81.40.5-0.3
Total locomotion distance, hab. session 10.91.22.81.70.70.7
Locomotion velocity, hab. session 10.91.31.91.41.40.3
Time in familiar zone, hab. session 20.50.51.20.7-1.1-0.0
Time in novel zone, hab. session 21.51.53.3-1.01.80.5
Total zone transitions, hab. session 20.30.40.80.90.0-0.6
Total locomotion distance, hab. session 20.40.51.31.10.40.0
Locomotion velocity, hab. session 20.30.40.91.00.50.2
Novel to familiar place preference ratio0.30.40.80.50.90.2
Novelty place preference0.40.41.00.31.00.1
Time in novel zone, NPP test0.50.51.30.61.10.1
Total zone transitions, NPP test0.50.61.61.3-0.1-0.6
Total locomotion distance, NPP test1.72.35.02.20.81.1
Locomotion velocity, NPP test1.31.83.92.00.61.1
Intraocular pressure0.40.51.50.21.20.1
Delta distance traveled before/after self-admin0.10.10.30.50.2-0.1
Delta ambulatory time before/after self-admin0.00.00.0-0.10.0-0.0
Parametrial fat weight0.91.74.0-2.0-0.50.9
Pavlov. Cond. lever latency1.51.94.7-2.2-0.01.0
Pavlov. Cond. magazine entry latency1.01.32.81.7-0.70.8
Pavlov. Cond. change in total contacts2.32.57.32.70.1-0.2
Pavlov. Cond. index score1.01.33.81.9-0.10.2
Pavlov. Cond. latency score1.11.44.22.0-0.0-0.1
Pavlov. Cond. lever contacts1.21.43.41.9-0.3-0.7
Pavlov. Cond. magazine entry number1.11.43.1-1.80.4-0.9
Pavlov. Cond. intertrial magazine entries0.30.40.60.10.7-0.8
Pavlov. Cond. lever-magazine prob. diff.0.81.13.11.80.10.3
Pavlov. Cond. response bias1.11.33.71.9-0.10.5
Pavlov. Cond. lever latency0.10.10.20.4-0.4-0.2
Pavlov. Cond. magazine entry latency0.40.40.7-0.8-0.8-0.0
Pavlov. Cond. change in total contacts0.20.20.3-0.5-0.6-0.4
Pavlov. Cond. index score0.10.10.4-0.6-0.1-0.0
Pavlov. Cond. latency score0.10.20.5-0.70.2-0.0
Pavlov. Cond. lever contacts0.00.00.1-0.20.2-0.1
Pavlov. Cond. magazine entry number0.10.20.40.30.6-0.1
Pavlov. Cond. intertrial magazine entries1.72.24.4-2.10.11.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.6-0.8-0.30.1
Pavlov. Cond. response bias0.10.20.2-0.5-0.40.3
Time in closed arm before self-admin0.10.10.20.40.4-0.1
Time in closed arm after self-admin0.70.72.01.40.30.2
Time in open arm before self-admin0.10.20.50.7-0.10.0
Time in open arm after self-admin0.30.30.8-0.90.2-0.1
Bone: periosteal estimation5.110.519.6-4.42.12.7
Bone: periosteal perimeter2.84.79.4-3.11.61.5
Bone: post-yield work2.83.96.1-2.5-0.22.3
Progressive ratio test 1 active lever presses0.30.30.60.70.70.0
Progressive ratio test 1 breakpoint0.30.30.50.70.7-0.0
Progressive ratio test 1 inactive lever presses0.10.10.20.50.20.0
Progressive ratio test 2 active lever presses0.10.10.2-0.00.4-0.1
Progressive ratio test 2 breakpoint0.20.20.50.40.7-0.1
Progressive ratio test 2 inactive lever presses0.10.10.3-0.6-0.20.0
Incentive Sensitization - Responses0.10.10.4-0.6-0.2-0.1
Incentive Sensitization - Breakpoint0.10.10.2-0.5-0.2-0.1
Sum of active levers in priming session hrs 5-60.20.20.60.80.00.2
Progressive ratio1.21.44.2-2.0-0.10.2
Food seeking constrained by brief footshock0.40.51.1-0.5-1.0-0.3
Seeking ratio, punishment vs. effort0.60.72.01.4-0.4-0.2
Retroperitoneal fat weight0.20.82.21.50.1-0.4
Reaction time number correct0.81.12.6-1.6-0.60.6
Reaction time mean minus median0.70.91.2-1.0-1.1-0.7
Reaction time mean minus median AUC1.31.64.6-2.1-0.50.3
Reaction time num false alarms0.50.71.4-1.20.50.7
Reaction time num false alarms AUC1.01.43.7-1.90.00.8
Reaction time trials correct on left0.81.12.6-1.6-0.60.6
Reaction time trials on left0.81.22.9-1.7-0.60.6
Reaction time mean0.40.51.40.20.2-1.2
Reaction time mean AUC0.50.61.70.10.4-1.3
Median of all reaction times0.50.71.30.50.6-1.1
Reaction time omissions1.41.94.3-2.1-1.10.4
Reaction time false alarm rate0.10.20.3-0.60.30.4
Reaction time premature initiation rate1.62.15.42.3-0.80.5
Reaction time premature initiations0.70.91.20.8-1.11.0
Std. dev. reaction times0.30.50.8-0.9-0.6-0.5
Reaction time trials completed0.81.22.9-1.7-0.60.6
Reaction time trials AUC0.81.12.5-1.6-0.50.7
Run reversals in cocaine runway, females0.90.92.71.6-0.00.2
Run reversals in cocaine runway, males1.21.22.9-0.51.70.6
Latency to leave start box in cocaine runway1.01.01.80.91.30.7
Latency to leave start box in cocaine runway, F1.71.93.21.31.80.9
Latency to leave start box in cocaine runway, M0.00.00.10.2-0.1-0.2
Std. dev. time between licks in bursts1.11.33.10.6-0.7-1.8
Total sessions with >9 infusions0.00.10.1-0.30.30.1
Short access day 1 total inactive lever presses0.30.31.0-0.01.0-0.0
Short access day 10 total inactive lever presses0.30.41.11.10.1-0.0
Short access day 1 total infusions0.60.61.5-1.20.6-0.0
Short access day 10 total infusions0.30.30.5-0.70.70.1
Short access total infusions0.40.40.7-0.80.8-0.0
Short access day 1 locomotion0.91.02.11.40.90.1
Short access day 10 total locomotion0.00.10.10.3-0.10.3
Short access total locomotion0.30.30.91.00.20.2
One hour access (0.3 mA shock)0.10.20.3-0.50.5-0.1
Compulsive drug intake0.10.10.1-0.4-0.20.0
One hour access (shock baseline)0.40.41.3-1.10.2-0.0
Social response proportion1.61.74.3-0.60.72.1
Social responses0.10.20.50.7-0.1-0.1
Social time1.11.43.7-0.7-0.21.9
Soleus weight0.30.81.2-1.10.31.1
Bone: stiffness1.92.93.9-1.81.22.0
Tibialis anterior weight0.10.40.9-1.00.3-0.5
Time to tail flick, vehicle, before self-admin0.60.61.91.4-0.10.0
Time to tail flick, vehicle, after self-admin0.80.81.9-1.4-0.70.2
Time to tail flick, test, before self-admin0.40.40.80.50.9-0.1
Time to tail flick, test, after self-admin0.10.10.1-0.10.40.2
Delta time to tail flick, vehicle, before/after SA1.71.75.0-2.2-0.30.1
Delta time to tail flick, test, before/after SA0.70.61.4-1.2-0.70.1
Tibia length0.20.71.80.10.5-1.3
Ambulatory time before self-admin0.20.20.60.8-0.10.2
Ambulatory time after self-admin0.20.20.50.70.10.2
Bone: tissue strength1.11.12.01.1-1.40.4
Total heroin consumption1.41.75.0-2.20.2-0.1
Bone: trabecular number1.52.33.7-1.9-1.70.7
Bone: trabecular spacing0.91.23.61.9-0.0-0.2
Bone: trabecular thickness0.50.61.2-1.1-0.10.7
Bone: trabecular tissue density0.10.20.20.4-0.5-0.4
Water consumed over 24 hours0.10.20.50.7-0.1-0.3
Number of responses in last shaping day0.60.61.91.4-0.00.1