LOC120095204

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120095204	0.04	0.03	1.9e-03	0.03	0.03	0.03	0.03	1.2e-03	1.3e-03	9.4e-04	3.9e-04
2	pVTA	gene expression	LOC120095204	0.16	0.07	5.9e-06	0.07	0.09	0.11	0.06	5.4e-04	1.2e-04	1.3e-05	2.0e-03
3	BLA	gene expression	LOC120095204	0.08	0.04	3.1e-04	0.05	0.04	0.02	0.05	8.2e-04	2.0e-03	2.2e-02	1.0e-03
4	Liver	gene expression	LOC120095204	0.29	0.08	0.0e+00	0.16	0.16	0.16	0.16	5.4e-17	4.9e-17	2.2e-17	2.5e-17
5	PL	gene expression	LOC120095204	0.06	0.03	1.8e-04	0.01	0.03	0.04	0.02	1.9e-02	1.0e-04	4.9e-05	1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	3.4	5.7	8.2	2.8	-2.1	-2.9	0.5	-2.8
Area under the delay curve	0.3	0.3	0.9	1.0	-0.6	-0.5	-0.2	-0.3
BMI with tail	2.9	9.5	14.7	-2.9	1.3	3.7	-3.1	3.8
BMI without tail	4.0	8.3	19.8	-1.0	1.6	2.3	-4.4	3.6
Body weight	2.3	9.7	19.3	-2.6	1.2	3.0	-3.5	4.4
Weight adjusted by age	1.3	1.4	3.8	-1.5	-0.3	1.9	0.2	0.9
Bone surface	6.0	10.5	16.4	3.9	-3.4	-4.0	-0.2	-3.1
Bone volume	5.7	9.7	13.8	3.7	-3.5	-3.7	-0.5	-2.9
Breakpoint value in progressive ratio session	1.3	1.5	2.6	-1.3	1.6	1.3	-0.3	1.1
Number of licking bursts	0.1	0.1	0.3	0.6	-0.3	-0.3	-0.0	-0.1
Context. condit. distance diff. score	0.1	0.1	0.3	-0.6	0.3	0.1	0.3	0.2
Locomotion velocity, session 1	0.1	0.2	0.5	-0.1	0.2	-0.0	-0.7	0.4
Locomotion distance, session 1	0.4	0.6	1.2	-1.0	-0.2	0.2	-1.1	0.7
Locomotion velocity, session 2	0.4	0.5	2.2	-0.3	0.1	0.1	-1.5	0.5
Locomotion distance, session 2	0.4	0.5	1.2	-0.9	0.1	0.5	-1.1	0.4
Locomotion velocity, session 3	2.4	2.8	5.0	-2.2	1.0	2.0	-1.4	1.5
Locomotion distance, session 3	0.2	0.3	0.7	-0.4	-0.8	-0.5	0.2	-0.5
Stereotopy head waving bouts, day 3	1.6	1.9	4.1	-1.4	2.0	1.5	1.2	0.1
Stereotopy head waving duration, day 3	0.4	0.4	0.7	-0.8	0.8	0.9	0.4	-0.0
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.1	-0.5
Locomotion distance, session 7	0.7	0.8	1.9	0.5	-1.4	-1.2	-0.4	-0.6
Stereotopy head waving bouts, day 7	0.3	0.4	1.3	-0.2	1.1	0.5	0.4	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.4	0.1	1.2	0.5	1.0	-0.6
Locomotion velocity, session 8	0.0	0.0	0.2	-0.1	-0.4	0.2	-0.1	-0.1
Locomotion distance, session 8	0.4	0.5	1.3	-1.0	0.1	0.4	-1.1	0.6
Degree of sensitization distance	0.1	0.1	0.3	0.5	-0.2	-0.3	-0.5	0.1
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.0	0.7	0.5	-0.3	0.2
Conditioned locomotion	0.2	0.3	0.7	0.5	0.1	-0.6	-0.9	0.2
Cocaine response after cond. corrected	1.4	1.6	2.7	1.6	-1.6	-1.2	0.2	-1.2
Cocaine response after cond. not corrected	1.4	1.5	2.5	1.6	-1.4	-1.4	0.2	-1.0
Cocaine response before conditioning	0.2	0.3	0.4	-0.6	0.6	0.1	-0.6	0.5
Saline control response	4.7	6.1	9.3	-2.8	2.0	2.2	-2.1	3.0
Bone: connectivity density	2.1	3.4	6.6	2.1	-1.0	-2.6	0.3	-2.2
Bone: cortical apparent density	4.4	5.7	9.4	-3.1	3.1	2.3	0.8	2.0
Bone: cortical area	1.2	1.8	7.1	-0.2	-0.6	0.1	-2.7	1.2
Bone: cortical porosity	1.5	1.7	3.1	1.8	-0.9	-1.3	-1.6	-0.1
Bone: cortical porosity	1.5	1.7	3.2	1.6	-1.2	-1.0	-1.8	-0.0
Bone: cortical thickness	8.1	13.2	19.4	-4.4	3.5	4.1	-1.9	3.8
Bone: cortical thickness	3.0	3.4	5.2	-2.3	2.3	2.0	-0.5	1.7
Bone: cortical tissue density	4.2	5.5	9.1	-3.0	3.0	2.3	0.8	1.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	-0.4	-0.4	-0.6	-1.1	1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	-0.1	0.4	-0.9	0.4	0.7
Condit. Reinf. active responses	0.8	1.0	3.0	-0.0	-0.8	-0.6	-1.7	0.9
Condit. Reinf. inactive responses	1.1	1.3	4.0	0.6	-1.5	-0.1	-2.0	-0.0
Incentive salience index mean	0.3	0.3	0.9	-0.4	0.1	-0.3	-0.7	1.0
Condit. Reinf. lever presses	0.5	0.7	1.5	-1.2	0.7	0.7	-0.1	0.9
Condit. Reinf. active minus inactive responses	3.2	3.9	5.9	1.6	-2.4	-2.3	-2.4	-0.6
Condit. Reinf. active-inactive response ratio	3.6	3.7	6.1	2.0	-2.4	-2.5	-1.2	-1.2
Condit. Reinf. active responses	3.2	4.5	9.1	1.5	-2.5	-2.2	-3.0	-0.3
Condit. Reinf. inactive responses	1.4	1.7	6.6	-0.6	-0.1	0.1	-2.6	1.1
Condit. Reinf. lever presses	1.3	1.8	6.6	-0.2	-0.2	-0.6	-2.6	1.4
Condit. Reinf. lever reinforcers received	2.6	3.7	7.9	1.3	-2.1	-2.2	-2.8	-0.0
Conditioned reinforcement - actives	1.3	1.3	2.9	1.7	-0.5	-0.6	0.2	-1.7
Conditioned reinforcement - inactives	0.9	1.0	2.0	1.4	-1.4	-0.2	-0.5	-1.0
Conditioned locomotion	1.5	1.8	4.1	0.9	-2.0	-1.6	-0.9	-0.9
Patch foraging indifference point 0 sec	3.5	5.6	18.8	-1.1	0.4	0.9	-4.3	2.6
Patch foraging indifference point AUC	0.1	0.2	0.5	-0.3	0.2	-0.1	-0.5	0.7
Delay disc. indifference point, 0s delay	0.5	0.5	1.7	0.1	-0.3	-0.8	1.3	-0.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	0.8	-0.1	0.2	-0.6	0.4
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	0.7	-0.8	-0.9	0.1	-0.7
Delay disc. indifference point, 24s delay	1.1	1.1	2.4	1.6	-0.8	-0.7	-1.2	-0.5
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	1.0	0.1	-0.4	0.2	-0.4
Delay disc. indifference point, 8s delay	0.4	0.4	0.5	-0.6	0.7	0.7	0.7	0.4
Indifference point function ln k	0.5	0.6	3.1	0.0	-0.1	0.1	-1.8	-0.3
Indifference point function log k	0.5	0.6	3.1	0.0	-0.1	0.1	-1.8	-0.3
Patch foraging total patch changes 0 sec	3.5	5.7	18.6	-1.1	0.6	1.1	-4.3	2.6
Patch foraging total patch changes 12 sec	1.4	1.8	5.4	-0.7	0.0	-0.4	-2.3	1.7
Patch foraging total patch changes 18 sec	2.9	3.7	6.8	-2.0	0.2	1.5	-2.6	2.4
Patch foraging total patch changes 24 sec	2.3	2.8	12.1	0.4	-0.5	0.0	-3.5	1.2
Patch foraging total patch changes 6 sec	3.0	4.5	13.4	-1.3	0.3	0.2	-3.7	2.7
Patch foraging time to switch 0 sec	0.9	1.3	4.9	0.6	-0.7	-0.3	2.2	-0.9
Patch foraging water rate 0 sec	2.5	4.1	10.3	-1.3	1.3	0.5	-3.2	2.5
Patch foraging water rate 12 sec	2.3	3.5	5.7	-2.4	1.6	1.5	-1.6	2.2
Patch foraging water rate 18 sec	0.5	0.7	1.5	-0.9	1.2	0.5	-0.8	0.4
Patch foraging water rate 24 sec	0.4	0.5	1.5	-1.2	0.6	0.1	-0.6	0.4
Patch foraging water rate 6 sec	1.2	1.8	4.1	-1.3	2.0	0.9	-0.7	1.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.7	-1.3	0.3	1.0	-0.6	1.3
Distance traveled before self-admin	0.3	0.3	1.0	-0.4	-0.5	-0.1	1.0	-0.3
Distance traveled after self-admin	0.3	0.3	0.9	-1.0	0.1	-0.1	0.7	0.2
Extensor digitorum longus weight	0.4	1.5	3.4	-1.3	0.3	1.9	1.4	0.6
Bone: elastic displacement	1.0	1.1	1.9	-1.3	0.9	0.9	-1.4	0.7
Bone: elastic work	1.0	1.3	3.6	-0.8	0.8	0.5	-1.9	1.1
Bone: endosteal estimation	10.1	22.1	35.2	5.9	-5.6	-5.7	-1.7	-2.9
Bone: endosteal perimeter	10.9	22.6	36.3	5.6	-6.0	-5.7	-2.3	-2.8
Epididymis fat weight	2.1	4.8	8.3	-2.0	1.9	2.9	0.1	2.9
Delta time in closed arm before/after self-admin	2.8	2.7	4.2	1.8	-1.2	-1.6	1.4	-2.0
Delta time in open arm before/after self-admin	0.3	0.3	0.7	0.7	-0.1	0.6	0.1	-0.9
Diff in mean of infusions in LGA sessions	0.6	0.7	1.2	-1.1	0.5	1.1	-0.1	0.9
Delay discount exponential model param	0.6	0.6	1.6	-1.3	0.8	0.8	0.3	0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	0.4	-0.2	-0.4	0.2
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.4	-0.2	0.1	-0.3	-0.0
Bone: final force	0.6	1.0	1.8	1.3	-0.8	-1.3	-0.8	-0.2
Bone: final moment	0.6	1.0	1.8	1.3	-0.8	-1.3	-0.9	-0.2
Food consumed during 24 hour testing period	4.4	5.3	9.4	-2.0	3.1	2.7	-0.4	2.3
Glucose	0.3	0.4	1.1	-0.3	-1.0	0.0	0.5	-0.8
Heart weight	1.8	2.5	6.2	-0.1	-2.4	-0.7	-2.5	0.2
Delay discount hyperbolic model param	0.5	0.5	1.3	-1.2	0.7	0.7	0.3	0.4
Intermittent access intake day 1-15 change	0.6	0.6	1.7	-1.3	-0.2	-0.8	0.5	0.7
Intermittent access intake escalation	0.6	0.6	0.9	-0.9	-0.4	-0.9	0.9	0.3
Intermittent access intake escalation 2	0.8	0.8	2.7	-0.6	0.1	-1.6	1.0	0.4
Intermitt. access day 1 inactive lever presses	0.9	1.0	4.1	0.1	-0.0	0.1	-2.0	0.8
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.5	-0.3	-0.1	0.7	0.5	0.1
Intermitt. access escalation Index	0.4	0.3	0.6	0.8	0.8	-0.6	-0.0	0.1
Intermittent access day 1 total infusions	0.5	0.6	2.3	0.3	-0.3	0.8	-1.5	-0.1
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.3	-0.6	-0.6	-0.5	0.3
Intermittent access terminal intake (last 3 days)	0.3	0.3	1.1	0.5	-0.4	-1.1	-0.0	-0.1
Intermittent access total infusions	0.3	0.3	1.3	-0.2	-0.1	0.0	-1.1	0.4
Intermittent access day 1 locomotion	0.5	0.5	1.3	0.2	-1.2	0.1	-1.1	-0.1
Intermittent access day 15 total locomotion	0.8	0.9	2.5	0.2	-1.6	-1.2	-0.5	-0.5
Intermittent access total locomotion	0.7	0.8	2.3	-0.7	-0.8	-0.1	-1.5	0.7
Intermittent access standard deviation	0.7	0.8	2.8	-0.6	-1.7	-0.8	-0.2	-0.2
Left kidney weight	0.4	1.1	3.3	-0.7	-0.0	1.2	-1.8	0.8
Right kidney weight	0.1	0.4	1.1	-0.4	0.2	-0.2	-0.9	1.0
Cocaine induced anxiety	0.7	0.8	1.5	0.4	-0.8	-0.9	1.0	-1.2
Post-drug Anxiety	1.2	1.3	3.2	0.2	-0.9	-1.1	1.8	-1.2
Baseline Anxiety	0.7	0.8	1.3	-0.8	1.1	1.1	0.4	0.8
Tail length	0.5	1.6	4.5	0.9	0.6	-0.4	-2.1	1.5
Length with tail	0.2	0.6	1.9	-0.2	-0.0	-0.1	-1.0	1.4
Length without tail	0.4	1.0	4.0	-0.8	-0.2	0.1	2.0	-0.3
Times rat made contact with spout	0.7	0.8	1.6	-0.5	0.6	0.6	-1.1	1.3
Lifetime Intake	0.5	0.6	2.7	-0.1	-0.3	0.3	-1.6	0.3
Liver weight, left	0.1	0.1	0.2	0.4	0.5	-0.3	0.3	-0.3
Liver weight, right	1.2	2.1	5.7	-1.1	2.4	1.2	1.3	0.6
Locomotor activity	1.1	1.8	6.0	-0.5	0.6	0.5	-2.5	1.4
Locomotor testing distance	1.9	3.2	10.4	-1.2	0.3	0.5	-3.2	2.0
Locomotor testing rearing	3.6	5.6	9.4	-2.4	1.3	1.2	-3.1	3.1
Locomotion in novel chamber	0.3	0.4	0.8	0.9	-0.4	0.4	0.6	-0.6
Locomotion in novel chamber post-restriction	0.3	0.3	0.9	0.7	1.0	0.4	-0.3	0.1
Fecal boli incidents, locomotor time 1	1.6	1.8	3.6	0.8	-1.9	-1.5	0.6	-1.4
Change in fecal boli incidents, locomotor task	0.5	0.4	1.2	-0.5	1.1	0.2	0.3	0.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	-0.2	-0.1	0.9	-0.3	-0.2
Bouts of movement, locomotor time 1	0.4	0.5	0.9	-0.6	0.4	1.0	-0.2	0.9
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	0.1	0.4	0.3	0.3
Rest time, locomotor task time 1	0.4	0.5	1.3	-0.5	-0.7	-0.1	1.1	-0.7
Distance moved, locomotor task time 1	1.4	1.6	2.9	-0.6	1.7	1.6	-0.2	1.3
Vertical activity count, locomotor time 1	1.4	1.5	3.5	-0.5	1.9	1.4	-0.2	1.3
Time >=10cm from walls, locomotor time 2	2.5	2.6	6.1	-1.3	1.7	2.5	0.2	1.5
Bouts of movement, locomotor time 2	1.9	2.1	4.5	-1.2	1.1	2.1	-0.8	1.6
Total resting periods, locomotor time 2	1.2	1.3	3.2	-1.0	0.6	1.8	-0.7	1.1
Rest time, locomotor task time 2	4.3	5.0	10.1	2.1	-1.8	-1.0	2.4	-3.2
Distance moved, locomotor task time 2	6.2	7.2	12.4	-2.4	3.5	2.9	-0.1	3.1
Vertical activity count, locomotor time 2	5.5	6.0	10.2	-2.1	3.2	2.0	-1.3	3.2
Light reinforcement 1	1.7	3.2	4.4	-2.1	1.7	1.9	-1.4	1.7
Light reinforcement 2	0.0	0.1	0.1	0.0	-0.3	0.3	-0.3	-0.1
Bone: marrow area	9.9	21.4	34.5	5.9	-5.5	-5.6	-1.5	-2.9
Bone: maximum diameter	4.2	7.7	13.3	3.3	-3.7	-3.1	-1.3	-1.8
Bone: maximum force	1.2	2.0	3.1	1.5	-1.8	-1.7	-1.3	-0.3
Bone: maximum moment	1.2	2.0	2.9	1.5	-1.7	-1.7	-1.5	-0.2
Mean time between licks in bursts	0.1	0.1	0.4	-0.1	-0.6	-0.3	0.4	0.0
Mean num. licks in bursts	0.4	0.5	0.6	-0.8	0.5	0.7	-0.6	0.8
Cd content in liver	1.7	1.9	4.5	0.7	-0.5	-1.1	2.1	-1.7
Co content in liver	0.8	0.9	1.3	1.1	-0.7	-0.7	1.0	-1.1
Cu content in liver	0.9	1.1	2.1	1.3	-1.0	-0.9	0.5	-1.4
Fe content in liver	0.1	0.1	0.2	-0.3	0.2	-0.4	-0.0	0.0
K content in liver	0.9	0.9	2.2	1.5	-0.0	-1.1	0.1	-0.9
Mg content in liver	1.0	1.0	1.7	1.3	0.7	-1.2	0.7	-1.1
Mn content in liver	1.0	1.2	2.1	1.0	-0.1	-1.5	0.7	-1.4
Na content in liver	0.4	0.4	1.1	0.2	-0.3	-0.5	0.8	-1.1
Rb content in liver	0.5	0.6	2.4	-0.4	0.4	-0.1	1.5	-0.7
Se content in liver	0.1	0.2	0.3	-0.3	0.2	0.4	0.5	-0.5
Sr content in liver	0.5	0.5	1.3	0.1	-1.0	0.1	-1.1	0.1
Zn content in liver	1.3	1.4	3.1	1.8	-0.7	-0.8	-0.2	-1.7
Bone: minimum diameter	6.7	12.5	21.6	4.2	-4.6	-3.7	-2.8	-1.4
Time in familiar zone, hab. session 1	1.0	1.0	2.0	1.0	-1.4	-1.0	0.5	-0.7
Time in novel zone, hab. session 1	1.1	1.0	1.9	-1.0	1.4	0.8	-0.7	1.0
Total zone transitions, hab. session 1	1.0	1.3	2.2	-1.3	0.7	1.0	-1.1	1.5
Total locomotion distance, hab. session 1	2.0	2.8	4.2	-2.1	1.4	1.5	-1.3	2.0
Locomotion velocity, hab. session 1	1.7	2.4	3.6	-1.8	1.4	1.4	-1.1	1.9
Time in familiar zone, hab. session 2	0.5	0.5	0.9	0.6	-1.0	-0.7	-0.9	0.1
Time in novel zone, hab. session 2	0.6	0.6	1.4	-0.2	1.1	0.4	1.2	-0.5
Total zone transitions, hab. session 2	1.2	1.5	2.7	-1.0	0.8	1.6	-1.3	1.3
Total locomotion distance, hab. session 2	3.1	4.1	5.6	-2.4	1.9	2.3	-1.1	2.2
Locomotion velocity, hab. session 2	2.8	3.8	5.5	-2.4	1.9	2.3	-0.8	2.0
Novel to familiar place preference ratio	1.7	1.7	2.8	1.4	-1.6	-1.2	-1.7	-0.1
Novelty place preference	1.4	1.4	2.5	1.3	-1.6	-1.0	-1.3	-0.3
Time in novel zone, NPP test	1.2	1.3	1.9	1.3	-1.4	-1.0	-1.4	-0.2
Total zone transitions, NPP test	1.5	2.1	2.8	-1.3	1.1	1.6	-1.7	1.4
Total locomotion distance, NPP test	3.0	4.1	5.3	-2.3	2.3	2.0	-1.2	2.2
Locomotion velocity, NPP test	3.2	4.5	6.4	-2.5	2.1	2.3	-1.3	2.2
Intraocular pressure	1.9	2.6	9.7	-1.0	-1.0	0.3	-3.1	1.2
Delta distance traveled before/after self-admin	0.8	0.9	2.0	-0.8	1.4	0.9	-0.4	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.2	0.7	-0.5	0.1	0.1
Parametrial fat weight	1.2	2.2	3.4	1.8	0.1	-1.4	1.8	-1.7
Pavlov. Cond. lever latency	1.2	1.5	3.0	1.2	-0.8	-1.0	1.1	-1.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.8	-0.8	0.8	-0.1	-0.3	1.3
Pavlov. Cond. change in total contacts	0.8	0.8	2.2	-0.5	0.5	0.3	-1.2	1.5
Pavlov. Cond. index score	0.6	0.7	1.9	-0.9	0.7	0.3	-0.5	1.4
Pavlov. Cond. latency score	0.7	0.9	2.3	-1.0	0.8	0.4	-0.6	1.5
Pavlov. Cond. lever contacts	0.9	1.0	2.1	-1.0	0.6	0.8	-0.9	1.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.6	-0.4	0.2	-0.3	-0.7
Pavlov. Cond. intertrial magazine entries	3.6	4.3	11.3	1.4	-2.8	-0.7	-3.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.5	-0.8	0.6	0.2	-0.6	1.2
Pavlov. Cond. response bias	0.3	0.3	0.9	-0.5	0.5	0.2	-0.3	0.9
Pavlov. Cond. lever latency	1.3	1.7	4.5	-1.1	1.2	1.2	2.1	0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	0.1	-0.7	0.3	0.2	-0.5
Pavlov. Cond. change in total contacts	0.7	1.0	2.3	0.4	-1.2	-1.0	-1.5	-0.2
Pavlov. Cond. index score	0.9	1.2	2.1	0.9	-1.4	-0.9	-1.3	-0.6
Pavlov. Cond. latency score	0.9	1.1	2.1	0.9	-1.5	-0.8	-1.4	-0.5
Pavlov. Cond. lever contacts	0.6	0.9	3.2	0.6	-0.4	-0.7	-1.8	0.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.9	0.0	1.0	-0.4	0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.8	0.1	-0.8	-0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.2	0.9	-1.5	-0.9	-1.2	-0.6
Pavlov. Cond. response bias	0.5	0.7	1.4	0.9	-0.7	-0.9	-1.2	-0.2
Time in closed arm before self-admin	2.3	2.6	4.2	-1.0	1.4	1.8	-2.0	1.7
Time in closed arm after self-admin	0.2	0.2	0.3	0.1	0.4	0.5	-0.5	0.4
Time in open arm before self-admin	0.8	0.8	2.9	-1.1	-0.3	0.2	1.7	0.1
Time in open arm after self-admin	0.3	0.3	1.2	-0.0	-1.1	0.1	0.5	-0.4
Bone: periosteal estimation	5.7	11.8	17.9	4.1	-4.2	-3.9	-2.6	-1.4
Bone: periosteal perimeter	5.1	8.5	17.5	3.0	-4.2	-3.2	-2.0	-1.4
Bone: post-yield work	2.1	2.9	5.8	1.9	-2.4	-2.0	-0.4	-1.1
Progressive ratio test 1 active lever presses	3.9	4.0	4.6	-1.7	2.0	2.1	-2.0	2.2
Progressive ratio test 1 breakpoint	4.2	4.4	5.6	-1.6	2.0	2.1	-2.4	2.3
Progressive ratio test 1 inactive lever presses	2.3	2.5	6.0	-0.8	1.1	1.2	-2.4	1.9
Progressive ratio test 2 active lever presses	0.2	0.2	0.6	-0.2	0.3	0.2	-0.8	0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	-0.3	0.6	0.2	-0.7	0.5
Progressive ratio test 2 inactive lever presses	0.7	0.9	1.8	1.3	-1.0	-0.6	-0.8	-0.7
Incentive Sensitization - Responses	0.4	0.5	0.9	0.7	-0.7	-0.9	0.1	-0.7
Incentive Sensitization - Breakpoint	0.5	0.5	0.9	0.7	-0.7	-1.0	0.2	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	0.3	0.3	-0.4	0.5
Progressive ratio	1.6	1.8	2.7	1.5	-1.4	-0.8	1.1	-1.7
Food seeking constrained by brief footshock	0.6	0.7	1.8	1.1	-0.5	-1.3	0.3	-0.6
Seeking ratio, punishment vs. effort	0.6	0.7	1.2	-0.7	0.9	0.2	-1.0	1.1
Retroperitoneal fat weight	1.6	5.4	10.8	-2.0	2.2	2.5	-1.1	3.3
Reaction time number correct	0.4	0.5	1.6	0.6	-0.7	-0.5	0.0	-1.3
Reaction time mean minus median	0.9	1.2	3.9	0.6	1.2	-0.1	2.0	-0.3
Reaction time mean minus median AUC	0.7	1.0	1.6	1.2	0.7	-0.7	1.3	-0.8
Reaction time num false alarms	1.6	2.2	6.1	1.0	-1.9	-0.5	-2.5	-0.2
Reaction time num false alarms AUC	1.7	2.3	4.7	1.6	-1.8	-0.9	-2.2	-0.6
Reaction time trials correct on left	0.4	0.5	1.6	0.6	-0.7	-0.5	0.0	-1.3
Reaction time trials on left	0.4	0.6	1.7	0.7	-0.6	-0.6	0.1	-1.3
Reaction time mean	0.9	1.2	4.5	-0.1	1.2	-0.5	2.1	-0.0
Reaction time mean AUC	0.9	1.2	3.8	-0.3	1.5	-0.2	1.9	0.2
Median of all reaction times	0.7	1.0	3.6	-0.4	1.0	-0.6	1.9	0.1
Reaction time omissions	0.7	1.0	3.1	0.6	1.0	-0.7	1.8	-0.4
Reaction time false alarm rate	0.8	1.1	3.2	0.8	-1.2	-0.4	-1.8	0.2
Reaction time premature initiation rate	0.5	0.7	1.6	-0.8	-0.5	0.0	-1.3	1.0
Reaction time premature initiations	0.3	0.5	1.3	-0.3	-0.8	-0.5	-1.1	0.2
Std. dev. reaction times	1.2	1.7	6.0	0.6	1.2	-0.5	2.4	-0.5
Reaction time trials completed	0.4	0.6	1.7	0.7	-0.6	-0.6	0.1	-1.3
Reaction time trials AUC	0.3	0.5	1.6	0.6	-0.5	-0.5	0.2	-1.3
Run reversals in cocaine runway, females	2.6	2.5	4.0	-1.6	1.1	2.0	1.6	1.4
Run reversals in cocaine runway, males	0.7	0.7	1.3	1.1	-1.0	-0.5	0.6	-0.7
Latency to leave start box in cocaine runway	6.1	6.6	10.9	-2.5	3.1	3.3	-0.7	2.4
Latency to leave start box in cocaine runway, F	5.9	6.5	11.5	-3.4	1.9	3.1	-1.0	2.5
Latency to leave start box in cocaine runway, M	3.3	3.2	10.2	-0.7	3.2	1.7	0.4	1.4
Std. dev. time between licks in bursts	0.6	0.7	1.2	-0.8	1.0	1.1	0.8	0.4
Total sessions with >9 infusions	1.2	1.3	4.3	-0.8	-0.2	1.0	-2.1	0.7
Short access day 1 total inactive lever presses	0.3	0.3	0.8	0.0	-0.9	0.5	-0.7	-0.3
Short access day 10 total inactive lever presses	0.3	0.3	0.6	0.5	-0.6	-0.8	-0.5	-0.2
Short access day 1 total infusions	1.7	1.8	4.1	-1.3	0.2	1.5	-2.0	0.9
Short access day 10 total infusions	1.5	1.7	5.4	-0.3	0.1	1.3	-2.3	1.1
Short access total infusions	1.3	1.5	6.0	-0.3	-0.2	0.9	-2.4	0.7
Short access day 1 locomotion	1.9	2.1	4.0	-1.2	0.9	1.4	-2.0	1.5
Short access day 10 total locomotion	0.8	0.8	2.3	-0.1	-1.5	0.3	-1.3	0.1
Short access total locomotion	1.8	1.8	3.6	-1.2	0.2	1.5	-1.9	1.4
One hour access (0.3 mA shock)	0.8	0.9	1.9	0.7	-0.6	-1.4	-1.3	-0.2
Compulsive drug intake	1.5	1.5	4.2	1.5	-0.8	-2.1	-0.3	-0.5
One hour access (shock baseline)	0.0	0.0	0.1	0.2	-0.2	0.1	0.1	-0.3
Social response proportion	1.2	1.3	2.4	1.5	-0.5	-1.5	0.9	-0.9
Social responses	0.3	0.4	0.8	-0.4	0.6	-0.2	-0.9	0.7
Social time	1.8	2.4	3.3	1.8	-1.4	-1.7	0.9	-1.7
Soleus weight	0.6	1.9	3.8	1.9	-1.9	-0.8	-0.6	-0.9
Bone: stiffness	0.6	0.9	2.0	1.4	-1.0	-1.2	0.1	-0.5
Tibialis anterior weight	0.1	0.5	1.5	-0.1	0.5	0.7	-0.4	1.2
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.7	-0.2	-1.2	-0.9	1.3	-1.2
Time to tail flick, vehicle, after self-admin	2.7	2.9	4.9	1.2	-2.2	-2.2	0.8	-1.6
Time to tail flick, test, before self-admin	3.0	2.9	6.5	2.5	-1.8	-1.7	0.7	-1.2
Time to tail flick, test, after self-admin	1.8	1.8	3.3	1.8	-1.6	-1.6	-0.2	-0.9
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	3.1	1.5	-0.8	-1.8	0.3	-1.0
Delta time to tail flick, test, before/after SA	0.9	0.8	1.4	0.6	-1.2	-1.2	-0.3	-0.9
Tibia length	0.3	0.8	2.0	-0.9	0.0	0.8	-1.0	1.4
Ambulatory time before self-admin	0.2	0.2	0.7	-0.3	-0.0	0.6	0.8	0.1
Ambulatory time after self-admin	0.3	0.3	0.6	-0.8	0.7	0.1	0.7	0.3
Bone: tissue strength	0.4	0.4	1.4	-1.2	0.5	0.6	0.1	0.1
Total heroin consumption	0.3	0.4	1.4	1.2	0.0	-0.5	0.2	-0.6
Bone: trabecular number	2.6	4.0	7.1	2.2	-1.3	-2.7	0.7	-2.4
Bone: trabecular spacing	2.1	2.8	4.0	-2.0	1.5	2.0	0.0	1.9
Bone: trabecular thickness	2.2	2.7	4.3	2.1	-1.9	-1.6	-0.9	-1.4
Bone: trabecular tissue density	1.2	1.6	2.7	-1.6	1.2	1.5	0.9	1.1
Water consumed over 24 hours	3.0	3.6	6.9	-1.8	2.6	2.2	-0.1	1.6
Number of responses in last shaping day	2.0	2.1	4.3	-1.7	0.8	2.1	-0.7	1.4