Hub : Genes

LOC120095200

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA XR_005490497.1 0.2 0.07 0.0e+00 0.16 0.17 0.17 0.17 1.2e-17 9.9e-19 3.0e-18 3.5e-18
2 Liver alternative polyA XR_005490496.1 0.21 0.08 0.0e+00 0.19 0.22 0.22 0.22 1.2e-20 1.4e-23 7.6e-24 8.0e-24
3 Liver gene expression LOC120095200 0.13 0.06 2.9e-15 0.12 0.11 0.11 0.12 5.4e-13 1.3e-12 1.2e-12 9.3e-13
4 Liver isoform ratio XR_005490496.1 0.09 0.04 4.6e-11 0.08 0.08 0.07 0.08 1.6e-09 1.7e-09 1.2e-08 6.8e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.10.10.30.3-0.6-0.30.3
Area under the delay curve0.40.50.50.6-0.70.7-0.7
BMI with tail0.82.64.70.8-0.62.2-2.2
BMI without tail1.63.44.61.6-1.32.1-2.1
Body weight2.711.417.02.6-2.24.1-4.1
Weight adjusted by age0.60.71.3-0.20.11.2-1.2
Bone surface1.83.15.42.0-2.31.2-1.2
Bone volume2.44.16.62.3-2.61.5-1.5
Breakpoint value in progressive ratio session0.30.30.6-0.80.7-0.30.3
Number of licking bursts0.50.60.80.7-0.60.9-0.9
Context. condit. distance diff. score0.10.10.20.3-0.30.4-0.4
Locomotion velocity, session 10.00.00.00.1-0.1-0.10.1
Locomotion distance, session 10.10.10.10.2-0.2-0.30.3
Locomotion velocity, session 20.40.40.8-0.20.2-0.90.9
Locomotion distance, session 20.50.71.3-0.40.4-1.11.1
Locomotion velocity, session 31.21.41.7-1.01.3-1.21.2
Locomotion distance, session 30.00.00.00.2-0.20.1-0.1
Stereotopy head waving bouts, day 37.89.19.9-2.92.9-3.13.1
Stereotopy head waving duration, day 33.64.35.2-1.81.9-2.32.3
Locomotion velocity, session 70.10.20.2-0.40.3-0.40.4
Locomotion distance, session 71.01.31.91.3-1.40.9-0.9
Stereotopy head waving bouts, day 73.23.64.3-2.12.0-1.81.8
Stereotopy head waving duration, day 76.07.28.2-2.92.8-2.62.6
Locomotion velocity, session 80.10.10.20.3-0.40.1-0.1
Locomotion distance, session 80.10.10.20.4-0.4-0.20.2
Degree of sensitization distance0.50.50.90.9-0.90.4-0.4
Degree of sensitization stereotypy1.41.52.1-1.51.4-1.01.0
Conditioned locomotion0.00.00.10.2-0.2-0.10.1
Cocaine response after cond. corrected0.80.90.90.8-1.00.9-0.9
Cocaine response after cond. not corrected1.01.21.21.0-1.11.1-1.1
Cocaine response before conditioning0.00.00.00.10.0-0.20.2
Saline control response0.10.10.20.20.10.5-0.5
Bone: connectivity density0.91.52.6-0.70.5-1.61.6
Bone: cortical apparent density3.24.24.5-2.12.1-2.02.0
Bone: cortical area1.52.33.51.9-1.61.2-1.2
Bone: cortical porosity3.23.54.32.1-2.01.7-1.7
Bone: cortical porosity4.65.05.62.4-2.32.1-2.1
Bone: cortical thickness2.33.85.0-1.82.2-1.81.8
Bone: cortical thickness3.44.04.5-1.72.0-2.12.1
Bone: cortical tissue density3.24.24.5-2.12.1-2.02.0
Condit. Reinf. active minus inactive responses4.85.46.72.6-2.42.1-2.1
Condit. Reinf. active-inactive response ratio1.21.31.31.1-1.11.2-1.2
Condit. Reinf. active responses4.25.17.02.6-2.51.9-1.9
Condit. Reinf. inactive responses0.60.71.41.2-1.10.4-0.4
Incentive salience index mean1.92.33.01.7-1.51.4-1.4
Condit. Reinf. lever presses0.00.00.00.10.10.1-0.1
Condit. Reinf. active minus inactive responses4.85.98.32.9-2.72.0-2.0
Condit. Reinf. active-inactive response ratio4.64.85.92.4-2.41.9-1.9
Condit. Reinf. active responses5.57.611.03.3-3.12.2-2.2
Condit. Reinf. inactive responses0.50.61.51.2-1.00.2-0.2
Condit. Reinf. lever presses2.83.85.52.3-2.01.7-1.7
Condit. Reinf. lever reinforcers received5.27.410.53.2-3.12.2-2.2
Conditioned reinforcement - actives2.12.12.7-1.21.3-1.71.7
Conditioned reinforcement - inactives0.10.10.30.6-0.40.3-0.3
Conditioned locomotion2.12.63.21.7-1.81.4-1.4
Patch foraging indifference point 0 sec3.65.88.72.9-2.42.1-2.1
Patch foraging indifference point AUC0.91.11.21.1-1.01.0-1.0
Delay disc. indifference point, 0s delay0.10.10.2-0.0-0.20.5-0.5
Delay disc. indifference point, 16s delay0.70.71.00.5-0.71.0-1.0
Delay disc. indifference point, 2s delay0.30.40.50.5-0.70.6-0.6
Delay disc. indifference point, 24s delay1.31.21.61.2-1.21.0-1.0
Delay disc. indifference point, 4s delay0.10.10.10.1-0.30.3-0.3
Delay disc. indifference point, 8s delay0.40.40.6-0.80.8-0.50.5
Indifference point function ln k1.01.42.4-0.60.7-1.51.5
Indifference point function log k1.01.42.4-0.60.7-1.51.5
Patch foraging total patch changes 0 sec3.04.97.52.7-2.21.9-1.9
Patch foraging total patch changes 12 sec4.25.46.92.6-2.32.1-2.1
Patch foraging total patch changes 18 sec1.52.02.61.6-1.21.4-1.4
Patch foraging total patch changes 24 sec3.94.77.02.7-2.31.8-1.8
Patch foraging total patch changes 6 sec8.011.813.73.7-3.33.4-3.4
Patch foraging time to switch 0 sec0.10.20.4-0.2-0.10.6-0.6
Patch foraging water rate 0 sec0.81.32.11.4-1.20.9-0.9
Patch foraging water rate 12 sec0.00.00.00.10.20.1-0.1
Patch foraging water rate 18 sec0.70.91.3-0.70.8-1.11.1
Patch foraging water rate 24 sec0.60.81.2-0.60.6-1.11.1
Patch foraging water rate 6 sec0.50.80.9-0.80.8-0.90.9
Seeking ratio, delayed vs. immediate footshock1.41.62.21.0-1.01.5-1.5
Distance traveled before self-admin0.30.30.50.1-0.40.7-0.7
Distance traveled after self-admin0.30.40.50.3-0.50.7-0.7
Extensor digitorum longus weight0.31.11.9-1.41.40.5-0.5
Bone: elastic displacement1.82.02.4-1.21.3-1.61.6
Bone: elastic work0.20.20.4-0.40.6-0.50.5
Bone: endosteal estimation16.435.741.06.2-6.45.6-5.6
Bone: endosteal perimeter17.436.142.86.4-6.55.5-5.5
Epididymis fat weight1.33.06.00.4-0.22.4-2.4
Delta time in closed arm before/after self-admin0.10.10.10.0-0.1-0.40.4
Delta time in open arm before/after self-admin2.82.73.4-1.41.5-1.81.8
Diff in mean of infusions in LGA sessions0.20.20.4-0.30.20.6-0.6
Delay discount exponential model param0.91.01.1-0.91.0-1.01.0
Extinction: sum of active levers before priming0.50.50.70.3-0.60.8-0.8
Active lever presses in extinction session 60.20.20.40.2-0.30.7-0.7
Bone: final force1.11.72.11.5-1.41.2-1.2
Bone: final moment0.91.52.01.4-1.41.0-1.0
Food consumed during 24 hour testing period0.30.40.8-0.70.9-0.40.4
Glucose0.00.00.0-0.10.00.1-0.1
Heart weight4.66.56.92.6-2.52.5-2.5
Delay discount hyperbolic model param0.70.70.8-0.80.9-0.90.9
Intermittent access intake day 1-15 change1.61.62.11.1-1.01.4-1.4
Intermittent access intake escalation1.31.31.71.0-0.91.3-1.3
Intermittent access intake escalation 22.02.02.11.4-1.31.4-1.4
Intermitt. access day 1 inactive lever presses0.40.41.01.0-0.70.3-0.3
Intermitt. access day 15 inactive lever presses0.20.30.50.10.00.7-0.7
Intermitt. access escalation Index0.10.10.1-0.40.1-0.20.2
Intermittent access day 1 total infusions0.20.20.3-0.10.4-0.50.5
Intermittent access day 15 total infusions1.11.21.31.2-0.91.2-1.2
Intermittent access terminal intake (last 3 days)1.31.41.71.3-1.11.2-1.2
Intermittent access total infusions0.10.10.40.6-0.20.2-0.2
Intermittent access day 1 locomotion1.21.21.61.3-1.01.1-1.1
Intermittent access day 15 total locomotion2.12.33.01.7-1.51.4-1.4
Intermittent access total locomotion2.93.34.52.1-1.71.7-1.7
Intermittent access standard deviation1.61.71.91.4-1.21.3-1.3
Left kidney weight0.20.50.80.9-0.50.7-0.7
Right kidney weight0.92.53.21.5-1.31.8-1.8
Cocaine induced anxiety0.20.20.4-0.40.3-0.60.6
Post-drug Anxiety0.00.10.2-0.50.1-0.00.0
Baseline Anxiety0.40.40.9-1.00.8-0.30.3
Tail length1.23.74.51.8-1.62.1-2.1
Length with tail1.76.28.02.2-1.92.8-2.8
Length without tail0.10.20.50.00.10.7-0.7
Times rat made contact with spout0.20.20.30.5-0.30.6-0.6
Lifetime Intake0.10.10.30.6-0.1-0.10.1
Liver weight, left0.30.50.7-0.50.4-0.80.8
Liver weight, right1.21.92.2-1.51.5-1.31.3
Locomotor activity0.61.01.71.3-1.00.8-0.8
Locomotor testing distance0.81.42.21.5-1.21.0-1.0
Locomotor testing rearing0.71.01.21.0-0.81.1-1.1
Locomotion in novel chamber0.10.20.2-0.40.10.5-0.5
Locomotion in novel chamber post-restriction0.00.10.1-0.10.3-0.20.2
Fecal boli incidents, locomotor time 10.91.01.20.9-1.11.0-1.0
Change in fecal boli incidents, locomotor task0.00.00.0-0.10.00.1-0.1
Time >=10cm from walls, locomotor time 11.51.61.8-1.01.3-1.41.4
Bouts of movement, locomotor time 10.10.10.20.1-0.00.4-0.4
Total resting periods, locomotor time 10.10.10.20.0-0.10.4-0.4
Rest time, locomotor task time 10.10.10.3-0.60.4-0.10.1
Distance moved, locomotor task time 10.40.50.8-0.70.9-0.50.5
Vertical activity count, locomotor time 10.20.20.2-0.40.5-0.50.5
Time >=10cm from walls, locomotor time 21.21.22.2-1.51.5-0.50.5
Bouts of movement, locomotor time 20.10.10.1-0.30.30.3-0.3
Total resting periods, locomotor time 20.00.00.1-0.20.10.3-0.3
Rest time, locomotor task time 21.51.72.1-1.51.2-1.31.3
Distance moved, locomotor task time 21.21.42.6-1.41.6-0.70.7
Vertical activity count, locomotor time 20.00.00.10.10.20.2-0.2
Light reinforcement 10.30.60.6-0.70.8-0.80.8
Light reinforcement 20.00.10.1-0.30.3-0.20.2
Bone: marrow area15.734.139.16.1-6.35.5-5.5
Bone: maximum diameter4.99.111.63.4-3.42.6-2.6
Bone: maximum force2.54.35.32.3-2.31.9-1.9
Bone: maximum moment2.44.25.32.3-2.21.8-1.8
Mean time between licks in bursts1.01.42.20.9-0.81.5-1.5
Mean num. licks in bursts0.20.20.3-0.40.4-0.60.6
Cd content in liver1.61.72.1-1.51.3-1.21.2
Co content in liver0.10.10.2-0.20.10.4-0.4
Cu content in liver0.00.10.10.3-0.40.0-0.0
Fe content in liver0.10.10.30.00.0-0.50.5
K content in liver0.30.30.5-0.20.2-0.70.7
Mg content in liver2.22.33.2-1.21.1-1.81.8
Mn content in liver1.51.72.6-1.00.9-1.61.6
Na content in liver0.50.60.8-0.60.5-0.90.9
Rb content in liver1.31.72.0-1.11.2-1.41.4
Se content in liver1.21.51.6-1.21.3-1.21.2
Sr content in liver1.51.41.61.1-1.11.3-1.3
Zn content in liver0.50.50.9-0.30.4-1.01.0
Bone: minimum diameter14.226.630.45.5-5.54.8-4.8
Time in familiar zone, hab. session 12.52.32.51.5-1.61.5-1.5
Time in novel zone, hab. session 11.41.31.4-1.11.1-1.21.2
Total zone transitions, hab. session 10.00.00.00.00.00.1-0.1
Total locomotion distance, hab. session 10.10.10.2-0.20.4-0.30.3
Locomotion velocity, hab. session 10.10.10.2-0.30.5-0.30.3
Time in familiar zone, hab. session 22.42.52.71.6-1.61.5-1.5
Time in novel zone, hab. session 24.04.04.5-1.91.9-2.12.1
Total zone transitions, hab. session 20.10.20.2-0.40.5-0.40.4
Total locomotion distance, hab. session 20.50.70.9-0.80.9-0.70.7
Locomotion velocity, hab. session 20.91.31.5-1.11.2-1.01.0
Novel to familiar place preference ratio4.74.85.02.2-2.22.2-2.2
Novelty place preference3.13.23.21.8-1.81.8-1.8
Time in novel zone, NPP test2.72.83.01.7-1.71.6-1.6
Total zone transitions, NPP test0.60.81.3-0.50.5-1.21.2
Total locomotion distance, NPP test1.01.42.0-0.80.9-1.41.4
Locomotion velocity, NPP test0.70.91.3-0.70.8-1.11.1
Intraocular pressure1.01.41.51.2-1.21.2-1.2
Delta distance traveled before/after self-admin0.80.91.0-0.80.9-1.01.0
Delta ambulatory time before/after self-admin0.00.00.00.1-0.2-0.20.2
Parametrial fat weight0.10.30.4-0.70.3-0.60.6
Pavlov. Cond. lever latency0.81.01.4-0.90.6-1.21.2
Pavlov. Cond. magazine entry latency1.31.72.11.5-1.21.3-1.3
Pavlov. Cond. change in total contacts1.61.72.01.3-1.11.4-1.4
Pavlov. Cond. index score1.41.82.01.4-1.21.4-1.4
Pavlov. Cond. latency score1.41.82.21.3-1.11.5-1.5
Pavlov. Cond. lever contacts0.70.81.30.7-0.51.1-1.1
Pavlov. Cond. magazine entry number0.91.21.3-1.11.0-1.11.1
Pavlov. Cond. intertrial magazine entries5.76.98.42.9-2.82.4-2.4
Pavlov. Cond. lever-magazine prob. diff.1.21.51.71.3-1.11.3-1.3
Pavlov. Cond. response bias0.70.80.91.0-0.81.0-1.0
Pavlov. Cond. lever latency0.81.12.1-1.41.3-0.60.6
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.1-0.10.1
Pavlov. Cond. change in total contacts0.81.11.71.3-1.30.7-0.7
Pavlov. Cond. index score1.11.42.01.4-1.40.9-0.9
Pavlov. Cond. latency score1.01.21.91.4-1.30.8-0.8
Pavlov. Cond. lever contacts0.40.51.11.0-0.90.3-0.3
Pavlov. Cond. magazine entry number0.00.00.0-0.00.10.0-0.0
Pavlov. Cond. intertrial magazine entries0.30.40.60.8-0.80.5-0.5
Pavlov. Cond. lever-magazine prob. diff.1.01.31.91.4-1.40.8-0.8
Pavlov. Cond. response bias0.40.50.91.0-0.90.4-0.4
Time in closed arm before self-admin0.00.00.0-0.10.20.0-0.0
Time in closed arm after self-admin0.10.10.10.2-0.20.3-0.3
Time in open arm before self-admin0.50.61.10.4-0.31.0-1.0
Time in open arm after self-admin0.10.10.20.1-0.10.4-0.4
Bone: periosteal estimation11.523.928.35.3-5.34.4-4.4
Bone: periosteal perimeter9.816.318.64.3-4.33.8-3.8
Bone: post-yield work3.44.75.12.2-2.32.1-2.1
Progressive ratio test 1 active lever presses0.20.20.5-0.20.7-0.40.4
Progressive ratio test 1 breakpoint0.00.00.10.10.3-0.10.1
Progressive ratio test 1 inactive lever presses0.60.71.21.1-0.70.7-0.7
Progressive ratio test 2 active lever presses0.00.00.10.00.3-0.20.2
Progressive ratio test 2 breakpoint0.10.10.1-0.00.3-0.30.3
Progressive ratio test 2 inactive lever presses0.20.20.40.7-0.40.3-0.3
Incentive Sensitization - Responses0.00.00.00.0-0.10.1-0.1
Incentive Sensitization - Breakpoint0.00.00.0-0.0-0.10.0-0.0
Sum of active levers in priming session hrs 5-60.40.40.70.3-0.30.8-0.8
Progressive ratio0.10.10.1-0.0-0.10.3-0.3
Food seeking constrained by brief footshock0.20.30.30.5-0.60.5-0.5
Seeking ratio, punishment vs. effort0.00.00.10.3-0.1-0.00.0
Retroperitoneal fat weight1.03.25.61.1-0.72.4-2.4
Reaction time number correct0.40.60.9-0.60.5-1.01.0
Reaction time mean minus median0.20.20.4-0.60.60.3-0.3
Reaction time mean minus median AUC0.20.30.3-0.50.6-0.50.5
Reaction time num false alarms3.75.16.92.6-2.51.9-1.9
Reaction time num false alarms AUC3.95.47.42.7-2.61.9-1.9
Reaction time trials correct on left0.40.60.9-0.60.5-1.01.0
Reaction time trials on left0.40.60.8-0.60.5-0.90.9
Reaction time mean0.30.40.6-0.80.7-0.60.6
Reaction time mean AUC0.50.70.9-1.00.9-0.70.7
Median of all reaction times0.40.50.6-0.70.6-0.80.8
Reaction time omissions0.10.10.2-0.30.3-0.40.4
Reaction time false alarm rate3.65.16.32.5-2.42.0-2.0
Reaction time premature initiation rate3.44.64.82.1-2.12.2-2.2
Reaction time premature initiations1.62.22.61.6-1.61.4-1.4
Std. dev. reaction times0.30.40.7-0.80.8-0.40.4
Reaction time trials completed0.40.60.8-0.60.5-0.90.9
Reaction time trials AUC0.50.71.0-0.70.6-1.01.0
Run reversals in cocaine runway, females1.01.01.9-0.50.21.4-1.4
Run reversals in cocaine runway, males0.20.20.30.1-0.40.5-0.5
Latency to leave start box in cocaine runway1.82.02.6-1.51.6-1.21.2
Latency to leave start box in cocaine runway, F0.40.50.8-0.80.9-0.40.4
Latency to leave start box in cocaine runway, M2.92.73.5-1.61.9-1.51.5
Std. dev. time between licks in bursts1.01.21.6-1.21.3-0.90.9
Total sessions with >9 infusions0.00.00.00.20.1-0.20.2
Short access day 1 total inactive lever presses0.10.10.1-0.20.4-0.30.3
Short access day 10 total inactive lever presses0.50.51.01.0-0.80.5-0.5
Short access day 1 total infusions0.50.60.8-0.30.7-0.90.9
Short access day 10 total infusions0.40.50.90.9-0.50.6-0.6
Short access total infusions0.10.10.30.6-0.1-0.20.2
Short access day 1 locomotion0.00.00.10.3-0.10.1-0.1
Short access day 10 total locomotion3.03.33.81.9-1.61.9-1.9
Short access total locomotion1.41.41.81.3-1.01.2-1.2
One hour access (0.3 mA shock)0.50.61.51.2-0.90.1-0.1
Compulsive drug intake1.61.72.21.5-1.51.0-1.0
One hour access (shock baseline)0.10.10.10.00.2-0.30.3
Social response proportion1.31.41.71.0-1.31.3-1.3
Social responses1.41.82.21.5-1.31.2-1.2
Social time1.01.41.60.9-1.31.2-1.2
Soleus weight0.72.12.91.1-1.21.7-1.7
Bone: stiffness1.72.62.81.7-1.71.6-1.6
Tibialis anterior weight0.31.12.20.2-0.11.5-1.5
Time to tail flick, vehicle, before self-admin0.10.10.20.0-0.20.4-0.4
Time to tail flick, vehicle, after self-admin1.81.92.21.1-1.51.5-1.5
Time to tail flick, test, before self-admin4.24.15.11.5-2.02.3-2.3
Time to tail flick, test, after self-admin1.92.02.21.4-1.51.4-1.4
Delta time to tail flick, vehicle, before/after SA0.30.30.60.6-0.80.4-0.4
Delta time to tail flick, test, before/after SA0.20.20.40.6-0.5-0.20.2
Tibia length0.82.43.71.1-0.91.9-1.9
Ambulatory time before self-admin0.10.10.3-0.2-0.10.5-0.5
Ambulatory time after self-admin0.20.30.40.2-0.50.6-0.6
Bone: tissue strength2.42.32.8-1.31.4-1.71.7
Total heroin consumption0.10.10.20.3-0.40.2-0.2
Bone: trabecular number0.30.40.8-0.1-0.1-0.90.9
Bone: trabecular spacing0.10.10.2-0.30.40.2-0.2
Bone: trabecular thickness1.41.72.61.5-1.61.0-1.0
Bone: trabecular tissue density0.00.00.1-0.30.30.1-0.1
Water consumed over 24 hours1.41.72.2-1.21.5-1.21.2
Number of responses in last shaping day0.10.10.2-0.30.50.3-0.3