Hub : Genes

LOC120095200

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA XR_005490497.2 0.34 0.11 0.0e+00 0.24 0.3 0.28 0.28 4.1e-26 4.9e-33 8.6e-31 9.8e-31
2 Liver alternative polyA XR_005490494.2 0.29 0.14 7.4e-07 0.06 0.05 0.03 0.05 6.5e-07 1.3e-06 4.8e-04 2.6e-06
3 pVTA alternative polyA XR_005490497.2 0.3 0.12 1.7e-04 0.06 0.05 0.05 0.05 2.7e-05 4.6e-05 1.2e-04 3.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.71.33.50.51.90.3
Area under the delay curve0.10.10.20.50.2-0.2
BMI with tail0.93.23.92.0-1.9-1.4
BMI without tail1.33.95.72.4-2.3-0.9
Body weight2.912.521.94.7-1.3-3.7
Weight adjusted by age1.11.75.00.2-2.2-0.2
Bone surface2.74.99.72.13.1-0.7
Bone volume3.25.710.62.43.3-0.9
Breakpoint value in progressive ratio session1.72.12.4-1.3-1.61.4
Number of licking bursts0.40.61.50.60.2-1.2
Context. condit. distance diff. score0.10.10.20.40.1-0.4
Locomotion velocity, session 10.20.20.60.20.10.7
Locomotion distance, session 10.60.71.90.30.31.4
Locomotion velocity, session 20.81.02.2-0.20.81.5
Locomotion distance, session 21.52.05.8-0.40.42.4
Locomotion velocity, session 32.32.66.7-0.8-0.72.6
Locomotion distance, session 30.20.30.50.30.40.7
Stereotopy head waving bouts, day 35.05.99.2-3.0-1.12.7
Stereotopy head waving duration, day 32.22.74.5-2.1-0.51.8
Locomotion velocity, session 70.10.10.2-0.30.10.4
Locomotion distance, session 71.21.52.11.31.5-0.9
Stereotopy head waving bouts, day 72.93.33.9-2.0-1.61.9
Stereotopy head waving duration, day 74.45.37.5-2.7-2.02.1
Locomotion velocity, session 80.00.00.00.10.1-0.2
Locomotion distance, session 80.71.01.80.50.91.4
Degree of sensitization distance1.01.01.50.81.2-1.0
Degree of sensitization stereotypy1.92.12.8-1.2-1.71.4
Conditioned locomotion0.30.30.80.20.90.3
Cocaine response after cond. corrected0.81.01.80.80.8-1.3
Cocaine response after cond. not corrected1.21.52.90.90.8-1.7
Cocaine response before conditioning0.00.00.0-0.00.10.0
Saline control response0.71.02.10.5-1.40.7
Bone: connectivity density1.32.03.2-0.51.61.8
Bone: cortical apparent density3.14.25.9-2.4-1.72.0
Bone: cortical area1.32.03.21.61.80.6
Bone: cortical porosity2.42.64.82.21.7-0.4
Bone: cortical porosity2.62.86.22.51.4-0.6
Bone: cortical thickness3.65.910.3-1.9-2.03.2
Bone: cortical thickness4.25.010.8-1.9-0.83.3
Bone: cortical tissue density3.24.35.9-2.4-1.82.0
Condit. Reinf. active minus inactive responses3.74.15.62.42.1-1.6
Condit. Reinf. active-inactive response ratio1.41.53.00.90.9-1.7
Condit. Reinf. active responses3.54.36.32.52.4-0.9
Condit. Reinf. inactive responses1.31.62.31.31.50.9
Incentive salience index mean1.41.72.61.61.4-0.7
Condit. Reinf. lever presses0.10.20.50.0-0.30.7
Condit. Reinf. active minus inactive responses4.15.38.02.72.8-0.6
Condit. Reinf. active-inactive response ratio3.74.25.62.32.4-1.3
Condit. Reinf. active responses5.27.310.83.23.3-0.9
Condit. Reinf. inactive responses1.31.62.81.21.70.8
Condit. Reinf. lever presses2.02.85.12.31.7-0.4
Condit. Reinf. lever reinforcers received4.96.99.93.13.1-1.1
Conditioned reinforcement - actives0.20.41.00.31.00.3
Conditioned reinforcement - inactives0.40.50.90.90.6-0.6
Conditioned locomotion2.02.54.92.21.3-1.1
Patch foraging indifference point 0 sec2.03.77.62.81.9-0.1
Patch foraging indifference point AUC0.50.71.11.00.6-0.8
Delay disc. indifference point, 0s delay0.10.10.3-0.2-0.6-0.2
Delay disc. indifference point, 16s delay0.50.51.20.6-0.2-1.1
Delay disc. indifference point, 2s delay0.10.10.20.40.30.2
Delay disc. indifference point, 24s delay1.01.11.71.31.0-0.7
Delay disc. indifference point, 4s delay0.00.00.10.0-0.00.3
Delay disc. indifference point, 8s delay0.50.50.7-0.8-0.90.4
Indifference point function ln k1.01.83.8-0.61.11.9
Indifference point function log k1.01.83.8-0.61.11.9
Patch foraging total patch changes 0 sec1.63.06.22.51.60.1
Patch foraging total patch changes 12 sec2.43.15.52.31.7-1.0
Patch foraging total patch changes 18 sec0.50.72.01.40.40.0
Patch foraging total patch changes 24 sec2.13.56.02.42.10.1
Patch foraging total patch changes 6 sec4.46.713.23.62.2-1.5
Patch foraging time to switch 0 sec0.40.81.3-0.1-1.0-1.1
Patch foraging water rate 0 sec0.71.52.31.41.50.3
Patch foraging water rate 12 sec0.10.20.50.1-0.20.7
Patch foraging water rate 18 sec0.71.23.0-0.50.41.7
Patch foraging water rate 24 sec0.81.12.6-0.50.61.6
Patch foraging water rate 6 sec0.91.33.3-0.70.11.8
Seeking ratio, delayed vs. immediate footshock0.60.71.11.0-0.4-1.0
Distance traveled before self-admin0.50.71.0-0.6-0.91.0
Distance traveled after self-admin0.10.10.20.50.0-0.3
Extensor digitorum longus weight1.66.415.7-0.9-4.0-1.7
Bone: elastic displacement2.02.44.7-1.2-1.02.2
Bone: elastic work0.70.91.8-0.2-0.91.3
Bone: endosteal estimation13.228.835.86.05.5-4.6
Bone: endosteal perimeter14.631.238.96.25.9-4.5
Epididymis fat weight1.86.18.51.3-2.9-2.9
Delta time in closed arm before/after self-admin0.20.20.5-0.40.7-0.2
Delta time in open arm before/after self-admin1.01.01.9-1.0-0.11.4
Diff in mean of infusions in LGA sessions1.11.32.7-1.0-1.70.5
Delay discount exponential model param0.30.40.6-0.8-0.50.5
Extinction: sum of active levers before priming0.30.30.40.6-0.4-0.6
Active lever presses in extinction session 60.10.10.10.2-0.00.4
Bone: final force0.61.01.81.01.30.2
Bone: final moment0.61.02.01.01.40.3
Food consumed during 24 hour testing period1.01.32.6-0.5-1.61.1
Glucose0.00.10.1-0.0-0.3-0.3
Heart weight0.71.02.91.70.2-0.3
Delay discount hyperbolic model param0.30.30.5-0.7-0.40.5
Intermittent access intake day 1-15 change1.83.79.51.30.1-3.1
Intermittent access intake escalation1.63.27.81.40.1-2.8
Intermittent access intake escalation 23.43.98.81.60.7-3.0
Intermitt. access day 1 inactive lever presses0.20.71.11.10.2-1.0
Intermitt. access day 15 inactive lever presses0.81.63.50.5-1.1-1.9
Intermitt. access escalation Index0.20.30.6-0.4-0.70.2
Intermittent access day 1 total infusions0.40.71.50.40.51.2
Intermittent access day 15 total infusions1.21.73.11.80.5-1.4
Intermittent access terminal intake (last 3 days)2.12.84.22.11.1-1.8
Intermittent access total infusions0.81.01.81.31.0-0.4
Intermittent access day 1 locomotion1.11.43.41.80.7-0.6
Intermittent access day 15 total locomotion1.52.74.42.11.4-1.2
Intermittent access total locomotion3.03.67.52.71.5-1.0
Intermittent access standard deviation2.14.510.01.80.4-3.2
Left kidney weight0.00.20.50.7-0.3-0.0
Right kidney weight0.10.40.70.9-0.7-0.1
Cocaine induced anxiety0.30.41.30.21.1-0.0
Post-drug Anxiety0.40.40.8-0.30.50.9
Baseline Anxiety1.61.92.5-1.0-1.51.6
Tail length0.62.35.72.4-0.0-1.0
Length with tail1.67.010.83.30.0-3.2
Length without tail1.24.08.61.8-0.5-2.9
Times rat made contact with spout0.10.10.20.5-0.4-0.2
Lifetime Intake0.60.71.31.10.90.3
Liver weight, left1.62.74.02.01.7-1.0
Liver weight, right0.40.71.7-0.5-1.30.1
Locomotor activity0.91.42.01.41.01.1
Locomotor testing distance0.81.42.21.50.71.2
Locomotor testing rearing0.30.71.61.20.00.7
Locomotion in novel chamber0.70.91.6-0.9-1.30.7
Locomotion in novel chamber post-restriction0.10.10.2-0.3-0.2-0.4
Fecal boli incidents, locomotor time 11.32.04.10.90.9-2.0
Change in fecal boli incidents, locomotor task0.10.10.1-0.4-0.3-0.3
Time >=10cm from walls, locomotor time 10.50.51.3-1.1-0.30.5
Bouts of movement, locomotor time 10.10.10.30.3-0.50.1
Total resting periods, locomotor time 10.20.20.30.2-0.5-0.5
Rest time, locomotor task time 10.50.70.9-0.6-0.8-1.0
Distance moved, locomotor task time 10.50.70.9-0.6-0.90.9
Vertical activity count, locomotor time 10.10.30.5-0.4-0.50.7
Time >=10cm from walls, locomotor time 21.72.55.6-1.3-2.40.4
Bouts of movement, locomotor time 20.61.02.40.0-1.60.8
Total resting periods, locomotor time 20.40.61.40.1-1.20.7
Rest time, locomotor task time 20.70.92.4-1.5-0.5-0.4
Distance moved, locomotor task time 22.12.55.0-1.2-2.21.0
Vertical activity count, locomotor time 20.20.30.80.1-0.90.4
Light reinforcement 10.71.64.6-0.5-0.42.1
Light reinforcement 20.10.10.2-0.3-0.40.3
Bone: marrow area12.627.633.95.85.3-4.5
Bone: maximum diameter4.38.012.33.03.5-1.6
Bone: maximum force1.83.14.82.12.2-0.2
Bone: maximum moment1.83.25.22.12.3-0.3
Mean time between licks in bursts0.92.35.31.1-0.5-2.3
Mean num. licks in bursts0.30.41.1-0.3-0.31.1
Cd content in liver2.02.34.5-1.2-0.9-2.1
Co content in liver0.70.82.0-0.6-1.4-0.3
Cu content in liver0.20.30.40.40.5-0.6
Fe content in liver0.50.61.30.61.10.5
K content in liver0.20.20.3-0.30.40.5
Mg content in liver1.11.21.8-1.30.21.3
Mn content in liver2.52.76.0-1.40.62.4
Na content in liver0.30.40.6-0.7-0.20.8
Rb content in liver0.70.81.7-1.3-0.30.8
Se content in liver1.11.33.1-0.9-0.31.8
Sr content in liver0.40.40.70.8-0.3-0.6
Zn content in liver0.20.30.70.20.9-0.2
Bone: minimum diameter11.420.729.25.44.7-3.3
Time in familiar zone, hab. session 12.72.64.81.41.0-2.2
Time in novel zone, hab. session 11.41.43.1-0.9-0.51.8
Total zone transitions, hab. session 10.30.40.90.3-0.60.9
Total locomotion distance, hab. session 10.60.82.1-0.1-0.51.5
Locomotion velocity, hab. session 10.50.81.9-0.2-0.61.4
Time in familiar zone, hab. session 21.92.02.41.61.3-1.4
Time in novel zone, hab. session 22.32.33.5-1.9-0.71.7
Total zone transitions, hab. session 20.81.01.5-0.1-1.21.2
Total locomotion distance, hab. session 21.41.82.7-0.7-1.51.6
Locomotion velocity, hab. session 21.82.43.3-1.0-1.61.8
Novel to familiar place preference ratio2.62.94.82.21.2-1.5
Novelty place preference1.81.93.31.81.0-1.2
Time in novel zone, NPP test1.81.93.11.81.3-1.0
Total zone transitions, NPP test1.21.75.0-0.30.02.2
Total locomotion distance, NPP test1.62.15.7-0.8-0.22.4
Locomotion velocity, NPP test1.21.74.5-0.7-0.52.1
Intraocular pressure0.60.92.11.50.70.3
Delta distance traveled before/after self-admin0.10.10.20.50.4-0.1
Delta ambulatory time before/after self-admin0.91.11.41.21.2-0.8
Parametrial fat weight0.30.81.9-0.80.0-1.4
Pavlov. Cond. lever latency0.40.51.1-1.00.6-0.4
Pavlov. Cond. magazine entry latency0.50.71.41.20.8-0.1
Pavlov. Cond. change in total contacts0.70.72.11.50.3-0.1
Pavlov. Cond. index score0.60.72.01.40.5-0.1
Pavlov. Cond. latency score0.50.72.01.40.2-0.1
Pavlov. Cond. lever contacts0.40.50.80.9-0.80.1
Pavlov. Cond. magazine entry number0.60.71.3-1.1-0.90.2
Pavlov. Cond. intertrial magazine entries3.34.07.92.81.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.60.81.91.40.70.1
Pavlov. Cond. response bias0.30.40.80.90.50.2
Pavlov. Cond. lever latency1.01.32.6-1.1-1.6-0.1
Pavlov. Cond. magazine entry latency0.10.20.20.10.5-0.5
Pavlov. Cond. change in total contacts0.81.32.51.11.6-0.1
Pavlov. Cond. index score1.11.52.61.31.6-0.4
Pavlov. Cond. latency score1.01.32.61.11.6-0.3
Pavlov. Cond. lever contacts0.81.12.11.01.40.5
Pavlov. Cond. magazine entry number0.00.00.00.1-0.10.0
Pavlov. Cond. intertrial magazine entries0.40.60.90.91.0-0.0
Pavlov. Cond. lever-magazine prob. diff.1.11.42.81.21.7-0.3
Pavlov. Cond. response bias0.81.12.31.01.50.2
Time in closed arm before self-admin0.30.40.60.3-0.80.7
Time in closed arm after self-admin0.50.61.5-0.2-1.2-0.4
Time in open arm before self-admin0.70.81.50.3-0.9-1.2
Time in open arm after self-admin0.10.10.20.40.3-0.2
Bone: periosteal estimation8.718.424.44.94.9-2.7
Bone: periosteal perimeter7.312.616.64.13.8-2.6
Bone: post-yield work2.84.26.42.51.7-1.7
Progressive ratio test 1 active lever presses0.40.50.80.9-0.40.8
Progressive ratio test 1 breakpoint0.40.50.91.0-0.30.8
Progressive ratio test 1 inactive lever presses0.81.13.31.80.2-0.1
Progressive ratio test 2 active lever presses0.10.10.20.5-0.00.3
Progressive ratio test 2 breakpoint0.10.10.30.5-0.00.3
Progressive ratio test 2 inactive lever presses0.00.10.10.4-0.2-0.0
Incentive Sensitization - Responses0.00.00.10.30.2-0.1
Incentive Sensitization - Breakpoint0.00.00.00.20.1-0.1
Sum of active levers in priming session hrs 5-60.50.50.9-0.6-1.0-0.1
Progressive ratio0.10.20.40.30.2-0.6
Food seeking constrained by brief footshock0.30.40.60.60.5-0.7
Seeking ratio, punishment vs. effort0.10.10.10.30.30.3
Retroperitoneal fat weight0.93.75.30.9-2.2-2.3
Reaction time number correct0.30.51.0-0.70.51.0
Reaction time mean minus median0.82.13.4-0.6-1.8-1.6
Reaction time mean minus median AUC0.20.50.5-0.7-0.7-0.6
Reaction time num false alarms3.34.67.62.82.5-0.1
Reaction time num false alarms AUC3.04.77.62.82.6-0.2
Reaction time trials correct on left0.30.51.0-0.70.51.0
Reaction time trials on left0.30.50.8-0.60.50.9
Reaction time mean0.50.81.2-1.1-0.8-0.7
Reaction time mean AUC0.71.11.7-1.3-1.1-0.6
Median of all reaction times0.40.61.5-1.2-0.3-0.3
Reaction time omissions0.40.61.5-0.3-0.4-1.2
Reaction time false alarm rate2.63.66.82.61.9-0.7
Reaction time premature initiation rate1.82.54.62.21.3-1.1
Reaction time premature initiations1.01.82.61.61.6-0.4
Std. dev. reaction times0.91.72.3-1.1-1.3-1.5
Reaction time trials completed0.30.50.8-0.60.50.9
Reaction time trials AUC0.30.50.7-0.70.40.9
Run reversals in cocaine runway, females2.92.96.9-0.3-2.6-1.3
Run reversals in cocaine runway, males0.10.10.30.0-0.1-0.5
Latency to leave start box in cocaine runway3.03.55.3-1.6-1.62.3
Latency to leave start box in cocaine runway, F1.51.72.4-0.8-1.41.6
Latency to leave start box in cocaine runway, M2.82.63.5-1.7-1.11.9
Std. dev. time between licks in bursts0.81.01.7-1.1-1.30.4
Total sessions with >9 infusions0.50.61.30.1-0.71.1
Short access day 1 total inactive lever presses0.30.31.00.1-0.01.0
Short access day 10 total inactive lever presses0.20.51.50.10.0-1.2
Short access day 1 total infusions1.11.44.20.1-0.12.0
Short access day 10 total infusions0.70.92.51.60.50.2
Short access total infusions0.70.91.80.70.61.4
Short access day 1 locomotion0.40.50.80.9-0.50.7
Short access day 10 total locomotion1.22.23.92.00.3-1.6
Short access total locomotion0.60.71.81.3-0.3-0.5
One hour access (0.3 mA shock)1.41.72.81.41.7-0.5
Compulsive drug intake1.31.52.41.21.6-0.8
One hour access (shock baseline)0.10.10.20.40.3-0.1
Social response proportion0.91.11.91.10.4-1.4
Social responses1.01.22.21.51.0-0.7
Social time1.11.63.80.90.3-1.9
Soleus weight0.41.32.41.5-0.2-1.2
Bone: stiffness1.11.72.81.41.7-0.7
Tibialis anterior weight0.51.84.10.7-2.0-0.9
Time to tail flick, vehicle, before self-admin0.60.71.9-0.2-0.2-1.4
Time to tail flick, vehicle, after self-admin0.10.20.20.40.5-0.4
Time to tail flick, test, before self-admin1.61.63.01.70.8-1.1
Time to tail flick, test, after self-admin1.41.51.81.21.1-1.4
Delta time to tail flick, vehicle, before/after SA0.30.30.70.30.80.1
Delta time to tail flick, test, before/after SA0.50.50.8-0.00.9-0.9
Tibia length0.51.31.51.0-1.2-1.1
Ambulatory time before self-admin1.11.72.1-1.1-1.51.4
Ambulatory time after self-admin0.00.10.10.2-0.20.3
Bone: tissue strength1.61.73.9-1.0-0.42.0
Total heroin consumption0.10.10.2-0.30.00.4
Bone: trabecular number1.01.73.4-0.11.81.4
Bone: trabecular spacing0.40.51.1-0.2-1.0-0.6
Bone: trabecular thickness1.72.14.01.42.0-0.6
Bone: trabecular tissue density0.30.51.0-0.7-1.00.1
Water consumed over 24 hours1.52.03.0-1.3-1.21.7
Number of responses in last shaping day0.91.02.6-0.2-1.6-0.6