LOC120095195

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC120095195	0.02	0.01	1.9e-03	0.02	0.02	0.02	0.02	1.6e-03	1.7e-03	3.7e-03	3.8e-03
2	RMTg	alternative polyA	XR_005490487.1	0.51	0.13	5.1e-06	0.32	0.23	0.28	0.3	3.1e-09	9.8e-07	3.4e-08	1.2e-08
3	RMTg	alternative polyA	XR_005490486.1	0.58	0.13	7.2e-07	0.34	0.24	0.29	0.32	5.9e-10	4.7e-07	2.1e-08	3.4e-09
4	RMTg	isoform ratio	XR_005490486.1	0.48	0.15	8.0e-05	0.23	0.07	0.11	0.17	6.4e-07	5.0e-03	7.7e-04	2.1e-05
5	RMTg	isoform ratio	XR_005490487.1	0.49	0.14	6.7e-05	0.24	0.08	0.1	0.19	4.2e-07	4.5e-03	1.2e-03	8.2e-06
6	Liver	alternative polyA	XR_005490487.1	0.09	0.05	2.1e-05	0.06	0.04	0.06	0.06	4.6e-07	3.5e-05	6.4e-07	9.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.6	2.3	-1.5	-0.5	0.5	0.5	-0.5	-0.5
Area under the delay curve	2.5	2.7	3.3	0.0	-1.8	1.8	1.8	-1.8	-1.7
BMI with tail	2.1	6.7	8.5	-0.8	2.8	-2.8	-2.8	2.8	2.9
BMI without tail	2.9	6.0	6.5	-2.0	2.5	-2.5	-2.5	2.5	2.5
Body weight	1.8	7.4	12.1	-3.5	2.5	-2.5	-2.5	2.5	2.7
Weight adjusted by age	1.6	1.8	1.9	1.2	-1.4	1.4	1.4	-1.4	-1.2
Bone surface	1.2	2.1	12.2	-3.5	-0.2	0.2	0.2	-0.2	-0.1
Bone volume	1.0	1.7	9.5	-3.1	-0.4	0.4	0.4	-0.4	-0.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	-0.1	-0.3
Number of licking bursts	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.2
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.2
Locomotion velocity, session 1	0.1	0.2	0.9	-0.9	-0.1	0.1	0.1	-0.1	-0.0
Locomotion distance, session 1	0.2	0.2	0.5	-0.7	-0.4	0.4	0.4	-0.4	-0.4
Locomotion velocity, session 2	0.1	0.2	0.4	-0.7	0.3	-0.3	-0.3	0.3	0.2
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	-0.2	0.2	0.2	-0.2	-0.2
Locomotion velocity, session 3	1.0	1.1	1.5	0.7	-1.1	1.1	1.1	-1.1	-1.2
Locomotion distance, session 3	1.6	1.8	2.5	-0.1	-1.4	1.4	1.4	-1.4	-1.6
Stereotopy head waving bouts, day 3	0.5	0.6	0.7	0.8	-0.7	0.7	0.7	-0.7	-0.7
Stereotopy head waving duration, day 3	1.3	1.5	1.7	0.9	-1.3	1.3	1.3	-1.3	-1.2
Locomotion velocity, session 7	0.5	0.5	0.7	0.2	0.8	-0.8	-0.8	0.8	0.8
Locomotion distance, session 7	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Stereotopy head waving bouts, day 7	0.9	1.0	1.4	1.2	-1.0	1.0	1.0	-1.0	-0.9
Stereotopy head waving duration, day 7	2.3	2.8	4.4	2.1	-1.6	1.6	1.6	-1.6	-1.6
Locomotion velocity, session 8	0.2	0.3	1.2	-1.1	0.2	-0.2	-0.2	0.2	0.4
Locomotion distance, session 8	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	-0.1	0.2
Degree of sensitization distance	1.0	1.0	1.4	-0.4	1.0	-1.0	-1.0	1.0	1.2
Degree of sensitization stereotypy	0.7	0.7	2.1	1.5	-0.7	0.7	0.7	-0.7	-0.6
Conditioned locomotion	0.3	0.4	0.4	-0.3	0.6	-0.6	-0.6	0.6	0.6
Cocaine response after cond. corrected	0.6	0.7	1.0	0.9	-0.7	0.7	0.7	-0.7	-1.0
Cocaine response after cond. not corrected	1.2	1.3	1.7	1.3	-1.0	1.0	1.0	-1.0	-1.3
Cocaine response before conditioning	0.9	1.1	1.2	0.6	-1.1	1.1	1.1	-1.1	-1.0
Saline control response	1.8	2.4	2.8	-0.6	1.7	-1.7	-1.7	1.7	1.7
Bone: connectivity density	0.5	0.7	3.7	-1.9	-0.4	0.4	0.4	-0.4	-0.4
Bone: cortical apparent density	0.4	0.6	2.9	1.7	-0.3	0.3	0.3	-0.3	-0.3
Bone: cortical area	0.7	1.1	4.9	-2.2	0.6	-0.6	-0.6	0.6	0.6
Bone: cortical porosity	1.5	1.7	3.4	-1.8	1.2	-1.2	-1.2	1.2	1.1
Bone: cortical porosity	0.4	0.4	2.0	-1.4	0.3	-0.3	-0.3	0.3	0.2
Bone: cortical thickness	0.3	0.4	2.6	1.6	0.0	-0.0	-0.0	0.0	-0.0
Bone: cortical thickness	0.9	1.0	1.7	1.3	0.9	-0.9	-0.9	0.9	0.9
Bone: cortical tissue density	0.4	0.5	3.0	1.7	-0.2	0.2	0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.9	-0.3	0.3	0.3	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	-0.5	0.5	0.5	-0.5	-0.6
Condit. Reinf. active responses	0.3	0.3	1.9	-1.4	-0.1	0.1	0.1	-0.1	-0.2
Condit. Reinf. inactive responses	0.3	0.3	1.8	-1.4	0.0	-0.0	-0.0	0.0	-0.0
Incentive salience index mean	0.1	0.2	0.9	-0.9	0.1	-0.1	-0.1	0.1	0.0
Condit. Reinf. lever presses	0.2	0.3	0.4	0.1	0.6	-0.6	-0.6	0.6	0.6
Condit. Reinf. active minus inactive responses	1.2	1.4	3.9	-2.0	-1.0	1.0	1.0	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.9	-0.5	0.5	0.5	-0.5	-0.7
Condit. Reinf. active responses	0.8	1.1	6.3	-2.5	-0.2	0.2	0.2	-0.2	-0.2
Condit. Reinf. inactive responses	0.8	1.0	3.8	-2.0	0.6	-0.6	-0.6	0.6	0.7
Condit. Reinf. lever presses	0.5	0.7	1.5	-1.2	0.7	-0.7	-0.7	0.7	0.8
Condit. Reinf. lever reinforcers received	0.7	0.9	5.5	-2.3	-0.1	0.1	0.1	-0.1	-0.1
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	0.1	-0.0
Conditioned reinforcement - inactives	0.6	0.7	4.3	-2.1	-0.0	0.0	0.0	-0.0	-0.2
Conditioned locomotion	1.4	1.6	2.9	-1.7	1.2	-1.2	-1.2	1.2	1.0
Patch foraging indifference point 0 sec	1.4	2.3	8.7	-2.9	1.0	-1.0	-1.0	1.0	1.1
Patch foraging indifference point AUC	0.5	0.6	3.3	-1.8	0.3	-0.3	-0.3	0.3	0.2
Delay disc. indifference point, 0s delay	1.6	1.7	2.0	0.8	-1.4	1.4	1.4	-1.4	-1.3
Delay disc. indifference point, 16s delay	0.8	0.8	1.0	0.1	-1.0	1.0	1.0	-1.0	-1.0
Delay disc. indifference point, 2s delay	1.5	1.7	2.3	-0.7	-1.4	1.4	1.4	-1.4	-1.5
Delay disc. indifference point, 24s delay	0.3	0.3	1.5	-1.2	-0.2	0.2	0.2	-0.2	0.2
Delay disc. indifference point, 4s delay	2.9	3.0	3.5	1.1	-1.9	1.9	1.9	-1.9	-1.7
Delay disc. indifference point, 8s delay	2.7	2.8	3.5	0.5	-1.9	1.9	1.9	-1.9	-1.5
Indifference point function ln k	0.2	0.3	1.1	1.0	-0.4	0.4	0.4	-0.4	-0.3
Indifference point function log k	0.2	0.3	1.1	1.0	-0.4	0.4	0.4	-0.4	-0.3
Patch foraging total patch changes 0 sec	1.3	2.1	8.8	-3.0	0.9	-0.9	-0.9	0.9	1.0
Patch foraging total patch changes 12 sec	1.6	2.1	9.7	-3.1	0.8	-0.8	-0.8	0.8	0.7
Patch foraging total patch changes 18 sec	1.1	1.4	4.8	-2.2	0.8	-0.8	-0.8	0.8	0.9
Patch foraging total patch changes 24 sec	1.0	1.2	6.9	-2.6	0.2	-0.2	-0.2	0.2	0.3
Patch foraging total patch changes 6 sec	1.1	1.7	7.2	-2.7	0.7	-0.7	-0.7	0.7	0.8
Patch foraging time to switch 0 sec	0.1	0.1	0.7	0.8	0.2	-0.2	-0.2	0.2	0.2
Patch foraging water rate 0 sec	1.1	1.8	4.9	-2.2	1.1	-1.1	-1.1	1.1	1.2
Patch foraging water rate 12 sec	0.1	0.1	0.4	0.7	-0.1	0.1	0.1	-0.1	-0.0
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.1
Patch foraging water rate 24 sec	0.3	0.5	0.6	0.3	-0.7	0.7	0.7	-0.7	-0.8
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.2	-0.1	0.1	0.1	-0.1	-0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.2	0.4	-0.4	-0.4	0.4	0.2
Distance traveled before self-admin	3.1	3.3	4.4	1.2	-1.9	1.9	1.9	-1.9	-2.1
Distance traveled after self-admin	1.0	1.1	1.7	0.8	-1.0	1.0	1.0	-1.0	-1.3
Extensor digitorum longus weight	0.7	2.8	3.0	1.6	1.7	-1.7	-1.7	1.7	1.7
Bone: elastic displacement	0.5	0.6	1.9	1.4	-0.6	0.6	0.6	-0.6	-0.6
Bone: elastic work	0.6	0.8	1.0	-0.6	1.0	-1.0	-1.0	1.0	0.8
Bone: endosteal estimation	3.6	7.8	32.7	-5.7	1.7	-1.7	-1.7	1.7	1.8
Bone: endosteal perimeter	3.1	6.5	35.7	-6.0	0.8	-0.8	-0.8	0.8	0.8
Epididymis fat weight	2.3	5.3	5.7	-2.0	2.4	-2.4	-2.4	2.4	2.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	-0.4	0.4	0.4	-0.4	-0.4
Delta time in open arm before/after self-admin	0.7	0.7	0.8	0.9	-0.8	0.8	0.8	-0.8	-0.8
Diff in mean of infusions in LGA sessions	0.4	0.4	1.1	1.0	0.5	-0.5	-0.5	0.5	0.5
Delay discount exponential model param	2.0	2.1	2.6	0.2	1.6	-1.6	-1.6	1.6	1.5
Extinction: sum of active levers before priming	0.3	0.3	0.4	-0.2	0.6	-0.6	-0.6	0.6	0.3
Active lever presses in extinction session 6	0.8	0.8	1.4	-1.2	0.8	-0.8	-0.8	0.8	0.9
Bone: final force	0.4	0.7	3.4	-1.8	0.3	-0.3	-0.3	0.3	0.4
Bone: final moment	0.4	0.7	3.7	-1.9	0.3	-0.3	-0.3	0.3	0.4
Food consumed during 24 hour testing period	3.7	4.5	4.7	-2.0	2.1	-2.1	-2.1	2.1	2.2
Glucose	0.4	0.5	1.5	1.2	-0.6	0.6	0.6	-0.6	-0.6
Heart weight	0.7	1.0	1.4	0.7	-1.0	1.0	1.0	-1.0	-1.2
Delay discount hyperbolic model param	2.3	2.5	3.0	0.1	1.7	-1.7	-1.7	1.7	1.6
Intermittent access intake day 1-15 change	2.1	2.1	2.5	-0.3	1.6	-1.6	-1.6	1.6	1.6
Intermittent access intake escalation	1.3	1.3	1.5	-0.0	1.2	-1.2	-1.2	1.2	1.2
Intermittent access intake escalation 2	3.8	3.8	4.5	-1.0	2.1	-2.1	-2.1	2.1	2.1
Intermitt. access day 1 inactive lever presses	0.8	0.8	4.9	-2.2	0.1	-0.1	-0.1	0.1	-0.1
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.2	-1.5	1.3	-1.3	-1.3	1.3	1.1
Intermitt. access escalation Index	1.1	0.9	3.5	1.9	-0.7	0.7	0.7	-0.7	-0.4
Intermittent access day 1 total infusions	0.4	0.5	0.9	-0.9	-0.6	0.6	0.6	-0.6	-0.9
Intermittent access day 15 total infusions	0.4	0.5	0.5	-0.6	0.7	-0.7	-0.7	0.7	0.5
Intermittent access terminal intake (last 3 days)	1.4	1.5	3.5	-1.9	1.1	-1.1	-1.1	1.1	0.8
Intermittent access total infusions	0.6	0.7	3.8	-2.0	0.3	-0.3	-0.3	0.3	-0.1
Intermittent access day 1 locomotion	0.7	0.7	4.0	-2.0	0.3	-0.3	-0.3	0.3	-0.1
Intermittent access day 15 total locomotion	3.2	3.4	7.0	-2.7	1.7	-1.7	-1.7	1.7	1.4
Intermittent access total locomotion	3.9	4.4	12.0	-3.5	1.8	-1.8	-1.8	1.8	1.3
Intermittent access standard deviation	1.2	1.2	1.9	-1.4	1.1	-1.1	-1.1	1.1	0.9
Left kidney weight	0.3	0.9	1.4	1.2	-0.9	0.9	0.9	-0.9	-0.9
Right kidney weight	0.1	0.2	0.6	0.8	-0.3	0.3	0.3	-0.3	-0.5
Cocaine induced anxiety	0.2	0.3	0.3	0.6	-0.5	0.5	0.5	-0.5	-0.4
Post-drug Anxiety	0.9	0.9	1.0	1.0	-1.0	1.0	1.0	-1.0	-1.0
Baseline Anxiety	0.2	0.2	1.1	1.1	0.1	-0.1	-0.1	0.1	-0.2
Tail length	0.5	1.6	6.8	-2.6	0.8	-0.8	-0.8	0.8	0.8
Length with tail	0.4	1.5	8.8	-3.0	-0.3	0.3	0.3	-0.3	-0.3
Length without tail	0.1	0.2	0.9	-1.0	-0.3	0.3	0.3	-0.3	-0.2
Times rat made contact with spout	0.7	0.8	0.9	-0.9	0.9	-0.9	-0.9	0.9	0.7
Lifetime Intake	0.7	0.8	4.5	-2.1	0.3	-0.3	-0.3	0.3	-0.0
Liver weight, left	0.2	0.3	1.4	-1.2	-0.3	0.3	0.3	-0.3	-0.4
Liver weight, right	0.2	0.4	0.5	-0.2	-0.7	0.7	0.7	-0.7	-0.7
Locomotor activity	0.3	0.5	0.6	-0.6	0.8	-0.8	-0.8	0.8	0.6
Locomotor testing distance	0.3	0.5	0.6	-0.7	0.7	-0.7	-0.7	0.7	0.7
Locomotor testing rearing	2.4	3.7	4.4	-0.6	2.1	-2.1	-2.1	2.1	2.0
Locomotion in novel chamber	1.2	1.5	2.2	0.1	-1.3	1.3	1.3	-1.3	-1.5
Locomotion in novel chamber post-restriction	0.5	0.7	3.2	-1.8	-0.4	0.4	0.4	-0.4	-0.3
Fecal boli incidents, locomotor time 1	1.0	1.1	1.4	0.5	-1.2	1.2	1.2	-1.2	-0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.2	0.4	-0.4	-0.4	0.4	0.0
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.3	1.2	-1.0	1.0	1.0	-1.0	-1.1
Bouts of movement, locomotor time 1	0.5	0.5	0.6	0.3	0.8	-0.8	-0.8	0.8	0.8
Total resting periods, locomotor time 1	0.3	0.4	0.4	0.3	0.7	-0.7	-0.7	0.7	0.6
Rest time, locomotor task time 1	0.2	0.2	0.4	0.7	-0.4	0.4	0.4	-0.4	-0.4
Distance moved, locomotor task time 1	0.8	0.8	1.3	-1.0	0.8	-0.8	-0.8	0.8	1.1
Vertical activity count, locomotor time 1	0.4	0.4	0.8	-0.7	0.5	-0.5	-0.5	0.5	0.9
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.7	0.3	1.3	-1.3	-1.3	1.3	1.2
Bouts of movement, locomotor time 2	0.9	1.0	1.2	0.4	1.1	-1.1	-1.1	1.1	1.1
Total resting periods, locomotor time 2	0.2	0.3	0.5	0.7	0.5	-0.5	-0.5	0.5	0.4
Rest time, locomotor task time 2	4.6	5.3	5.6	2.4	-2.3	2.3	2.3	-2.3	-2.2
Distance moved, locomotor task time 2	4.8	5.6	7.5	-1.1	2.5	-2.5	-2.5	2.5	2.7
Vertical activity count, locomotor time 2	6.5	7.1	10.1	-1.8	2.7	-2.7	-2.7	2.7	3.2
Light reinforcement 1	0.2	0.3	0.4	-0.2	0.6	-0.6	-0.6	0.6	0.7
Light reinforcement 2	0.6	0.8	0.9	-0.6	-0.9	0.9	0.9	-0.9	-1.0
Bone: marrow area	3.5	7.7	31.5	-5.6	1.7	-1.7	-1.7	1.7	1.8
Bone: maximum diameter	1.1	2.1	11.5	-3.4	-0.4	0.4	0.4	-0.4	-0.4
Bone: maximum force	0.6	1.1	6.2	-2.5	0.2	-0.2	-0.2	0.2	0.3
Bone: maximum moment	0.7	1.2	6.6	-2.6	0.3	-0.3	-0.3	0.3	0.4
Mean time between licks in bursts	0.1	0.2	0.3	-0.5	0.4	-0.4	-0.4	0.4	0.5
Mean num. licks in bursts	0.2	0.2	0.3	-0.6	0.4	-0.4	-0.4	0.4	0.4
Cd content in liver	0.8	0.9	4.2	2.0	-0.4	0.4	0.4	-0.4	-0.5
Co content in liver	0.1	0.2	0.5	0.7	-0.3	0.3	0.3	-0.3	-0.3
Cu content in liver	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1	0.1	0.0
Fe content in liver	0.1	0.1	0.2	0.5	-0.2	0.2	0.2	-0.2	-0.3
K content in liver	0.9	0.9	1.0	-1.0	-0.9	0.9	0.9	-0.9	-0.9
Mg content in liver	0.1	0.1	0.2	-0.5	-0.3	0.3	0.3	-0.3	-0.2
Mn content in liver	1.4	1.5	1.8	-0.2	-1.4	1.4	1.4	-1.4	-1.3
Na content in liver	2.3	2.5	3.0	-0.2	-1.7	1.7	1.7	-1.7	-1.7
Rb content in liver	1.7	2.1	2.2	1.3	-1.5	1.5	1.5	-1.5	-1.5
Se content in liver	4.6	5.6	6.7	1.3	-2.5	2.5	2.5	-2.5	-2.6
Sr content in liver	0.1	0.1	0.5	-0.7	0.2	-0.2	-0.2	0.2	0.2
Zn content in liver	4.5	5.0	6.0	-0.2	-2.5	2.5	2.5	-2.5	-2.4
Bone: minimum diameter	3.3	6.1	28.7	-5.4	1.3	-1.3	-1.3	1.3	1.4
Time in familiar zone, hab. session 1	0.6	0.5	0.9	-0.9	0.7	-0.7	-0.7	0.7	0.7
Time in novel zone, hab. session 1	0.2	0.1	0.9	0.9	0.1	-0.1	-0.1	0.1	0.1
Total zone transitions, hab. session 1	0.6	0.9	1.0	-0.7	1.0	-1.0	-1.0	1.0	0.9
Total locomotion distance, hab. session 1	1.0	1.4	2.1	-1.5	1.2	-1.2	-1.2	1.2	1.1
Locomotion velocity, hab. session 1	0.7	1.0	2.3	-1.5	0.9	-0.9	-0.9	0.9	0.8
Time in familiar zone, hab. session 2	0.5	0.5	1.5	-1.2	0.6	-0.6	-0.6	0.6	0.5
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.7	-0.5	0.5	0.5	-0.5	-0.4
Total zone transitions, hab. session 2	1.0	1.3	1.6	-0.5	1.2	-1.2	-1.2	1.2	1.3
Total locomotion distance, hab. session 2	1.6	2.1	2.2	-1.2	1.5	-1.5	-1.5	1.5	1.4
Locomotion velocity, hab. session 2	1.2	1.6	1.7	-1.2	1.3	-1.3	-1.3	1.3	1.2
Novel to familiar place preference ratio	0.3	0.4	1.2	-1.1	0.4	-0.4	-0.4	0.4	0.5
Novelty place preference	0.3	0.3	0.7	-0.8	0.5	-0.5	-0.5	0.5	0.6
Time in novel zone, NPP test	0.3	0.3	0.5	-0.7	0.5	-0.5	-0.5	0.5	0.6
Total zone transitions, NPP test	0.0	0.0	0.1	-0.3	-0.2	0.2	0.2	-0.2	-0.1
Total locomotion distance, NPP test	0.7	1.0	1.7	-1.3	0.9	-0.9	-0.9	0.9	0.9
Locomotion velocity, NPP test	0.3	0.4	1.1	-1.0	0.5	-0.5	-0.5	0.5	0.4
Intraocular pressure	0.1	0.2	0.3	-0.2	-0.5	0.5	0.5	-0.5	-0.2
Delta distance traveled before/after self-admin	0.4	0.4	0.8	0.4	0.7	-0.7	-0.7	0.7	0.9
Delta ambulatory time before/after self-admin	0.4	0.4	0.8	-0.2	0.6	-0.6	-0.6	0.6	0.9
Parametrial fat weight	0.6	1.2	2.5	-1.6	1.0	-1.0	-1.0	1.0	0.7
Pavlov. Cond. lever latency	0.3	0.3	0.9	0.9	-0.5	0.5	0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	2.6	-1.6	0.0	-0.0	-0.0	0.0	-0.0
Pavlov. Cond. change in total contacts	0.3	0.3	1.5	-1.2	0.3	-0.3	-0.3	0.3	0.4
Pavlov. Cond. index score	0.3	0.4	2.2	-1.5	0.1	-0.1	-0.1	0.1	0.1
Pavlov. Cond. latency score	0.2	0.3	1.7	-1.3	0.2	-0.2	-0.2	0.2	0.2
Pavlov. Cond. lever contacts	0.7	0.8	1.0	-0.7	0.9	-0.9	-0.9	0.9	1.0
Pavlov. Cond. magazine entry number	0.5	0.6	1.5	1.2	0.6	-0.6	-0.6	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.3	-1.2	-0.3	0.3	0.3	-0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.8	-1.3	-0.1	0.1	0.1	-0.1	-0.1
Pavlov. Cond. response bias	0.2	0.3	1.5	-1.2	-0.2	0.2	0.2	-0.2	-0.2
Pavlov. Cond. lever latency	0.3	0.3	0.4	0.2	0.6	-0.6	-0.6	0.6	0.6
Pavlov. Cond. magazine entry latency	2.2	2.5	3.0	1.7	-1.6	1.6	1.6	-1.6	-1.6
Pavlov. Cond. change in total contacts	0.6	0.8	1.0	-0.2	-1.0	1.0	1.0	-1.0	-1.0
Pavlov. Cond. index score	0.7	0.9	1.0	0.5	-1.0	1.0	1.0	-1.0	-1.0
Pavlov. Cond. latency score	1.0	1.3	1.5	0.6	-1.2	1.2	1.2	-1.2	-1.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	-0.1	-0.1
Pavlov. Cond. magazine entry number	2.7	3.3	4.7	-2.2	1.7	-1.7	-1.7	1.7	1.7
Pavlov. Cond. intertrial magazine entries	7.2	9.4	21.6	-4.6	2.6	-2.6	-2.6	2.6	2.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.4	0.5	-1.2	1.2	1.2	-1.2	-1.2
Pavlov. Cond. response bias	0.2	0.2	0.3	0.1	-0.5	0.5	0.5	-0.5	-0.5
Time in closed arm before self-admin	0.1	0.1	0.7	0.8	0.1	-0.1	-0.1	0.1	0.3
Time in closed arm after self-admin	0.0	0.0	0.1	0.4	0.0	-0.0	-0.0	0.0	0.3
Time in open arm before self-admin	0.2	0.2	0.8	0.9	0.3	-0.3	-0.3	0.3	0.1
Time in open arm after self-admin	0.3	0.3	0.5	0.3	-0.6	0.6	0.6	-0.6	-0.7
Bone: periosteal estimation	2.7	5.6	24.7	-5.0	1.3	-1.3	-1.3	1.3	1.4
Bone: periosteal perimeter	1.0	1.7	9.8	-3.1	-0.2	0.2	0.2	-0.2	-0.3
Bone: post-yield work	0.7	0.9	4.9	-2.2	0.3	-0.3	-0.3	0.3	0.3
Progressive ratio test 1 active lever presses	0.8	0.8	4.7	-2.2	0.3	-0.3	-0.3	0.3	-0.1
Progressive ratio test 1 breakpoint	1.0	1.0	5.6	-2.4	0.4	-0.4	-0.4	0.4	0.0
Progressive ratio test 1 inactive lever presses	1.0	1.1	6.6	-2.6	-0.1	0.1	0.1	-0.1	-0.2
Progressive ratio test 2 active lever presses	1.2	1.3	5.0	-2.2	-0.7	0.7	0.7	-0.7	-0.8
Progressive ratio test 2 breakpoint	1.0	1.1	5.7	-2.4	-0.4	0.4	0.4	-0.4	-0.4
Progressive ratio test 2 inactive lever presses	1.3	1.4	7.2	-2.7	-0.5	0.5	0.5	-0.5	-0.7
Incentive Sensitization - Responses	0.8	0.8	3.1	-1.8	-0.6	0.6	0.6	-0.6	-0.5
Incentive Sensitization - Breakpoint	0.7	0.7	3.0	-1.7	-0.6	0.6	0.6	-0.6	-0.4
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.8	1.4	-0.2	0.2	0.2	-0.2	0.1
Progressive ratio	1.9	2.2	2.7	-0.0	-1.6	1.6	1.6	-1.6	-1.5
Food seeking constrained by brief footshock	3.0	3.7	4.7	-2.2	1.8	-1.8	-1.8	1.8	2.1
Seeking ratio, punishment vs. effort	4.1	5.0	5.9	-1.2	2.4	-2.4	-2.4	2.4	2.3
Retroperitoneal fat weight	4.2	13.9	15.0	-3.1	3.9	-3.9	-3.9	3.9	3.7
Reaction time number correct	1.4	2.1	2.3	1.2	-1.5	1.5	1.5	-1.5	-1.3
Reaction time mean minus median	0.4	0.6	0.6	0.6	0.8	-0.8	-0.8	0.8	0.7
Reaction time mean minus median AUC	0.2	0.2	1.0	1.0	-0.2	0.2	0.2	-0.2	-0.2
Reaction time num false alarms	0.7	0.9	3.3	-1.8	-0.6	0.6	0.6	-0.6	-0.8
Reaction time num false alarms AUC	0.6	0.8	4.2	-2.0	-0.3	0.3	0.3	-0.3	-0.5
Reaction time trials correct on left	1.4	2.1	2.3	1.2	-1.5	1.5	1.5	-1.5	-1.3
Reaction time trials on left	1.4	2.0	2.2	1.2	-1.5	1.5	1.5	-1.5	-1.3
Reaction time mean	0.3	0.4	1.0	1.0	-0.5	0.5	0.5	-0.5	-0.5
Reaction time mean AUC	0.2	0.3	1.7	1.3	-0.1	0.1	0.1	-0.1	-0.2
Median of all reaction times	0.4	0.5	0.8	0.9	-0.7	0.7	0.7	-0.7	-0.7
Reaction time omissions	0.0	0.1	0.2	-0.4	0.2	-0.2	-0.2	0.2	0.2
Reaction time false alarm rate	0.7	1.0	4.6	-2.1	0.5	-0.5	-0.5	0.5	0.3
Reaction time premature initiation rate	0.3	0.4	1.0	-1.0	0.6	-0.6	-0.6	0.6	0.5
Reaction time premature initiations	0.0	0.1	0.1	-0.4	-0.2	0.2	0.2	-0.2	-0.2
Std. dev. reaction times	0.1	0.2	0.2	0.5	0.4	-0.4	-0.4	0.4	0.4
Reaction time trials completed	1.4	2.0	2.2	1.2	-1.5	1.5	1.5	-1.5	-1.3
Reaction time trials AUC	1.2	1.7	1.9	1.1	-1.4	1.4	1.4	-1.4	-1.2
Run reversals in cocaine runway, females	2.4	2.3	2.9	0.4	1.7	-1.7	-1.7	1.7	1.4
Run reversals in cocaine runway, males	1.0	1.0	1.2	0.3	-1.1	1.1	1.1	-1.1	-1.1
Latency to leave start box in cocaine runway	0.1	0.1	0.5	0.7	0.2	-0.2	-0.2	0.2	0.1
Latency to leave start box in cocaine runway, F	1.0	1.1	1.3	1.2	-1.0	1.0	1.0	-1.0	-1.1
Latency to leave start box in cocaine runway, M	2.6	2.5	3.1	-0.0	1.8	-1.8	-1.8	1.8	1.6
Std. dev. time between licks in bursts	0.3	0.4	0.5	-0.1	0.7	-0.7	-0.7	0.7	0.7
Total sessions with >9 infusions	1.2	1.3	2.0	-0.1	-1.2	1.2	1.2	-1.2	-1.4
Short access day 1 total inactive lever presses	0.6	0.7	1.9	-1.4	-0.7	0.7	0.7	-0.7	-0.6
Short access day 10 total inactive lever presses	0.5	0.5	1.5	-1.2	0.6	-0.6	-0.6	0.6	0.6
Short access day 1 total infusions	1.0	1.0	1.2	-0.8	-1.1	1.1	1.1	-1.1	-1.1
Short access day 10 total infusions	2.8	3.1	9.9	-3.1	1.4	-1.4	-1.4	1.4	1.1
Short access total infusions	0.6	0.6	3.7	-1.9	0.2	-0.2	-0.2	0.2	0.0
Short access day 1 locomotion	0.7	0.8	4.0	-2.0	0.4	-0.4	-0.4	0.4	0.3
Short access day 10 total locomotion	5.3	6.0	13.2	-3.6	2.2	-2.2	-2.2	2.2	1.9
Short access total locomotion	2.4	2.5	6.4	-2.5	1.4	-1.4	-1.4	1.4	1.2
One hour access (0.3 mA shock)	0.3	0.4	1.4	-1.2	0.4	-0.4	-0.4	0.4	0.3
Compulsive drug intake	0.4	0.4	1.3	1.1	-0.5	0.5	0.5	-0.5	-0.5
One hour access (shock baseline)	0.5	0.6	2.3	-1.5	0.6	-0.6	-0.6	0.6	0.4
Social response proportion	0.1	0.1	0.4	0.7	0.0	-0.0	-0.0	0.0	0.1
Social responses	0.7	0.8	1.3	-0.1	1.0	-1.0	-1.0	1.0	1.1
Social time	0.3	0.3	0.3	0.6	-0.6	0.6	0.6	-0.6	-0.6
Soleus weight	0.4	1.1	1.3	-0.0	-1.2	1.2	1.2	-1.2	-1.2
Bone: stiffness	0.3	0.5	3.0	-1.7	0.0	-0.0	-0.0	0.0	0.1
Tibialis anterior weight	1.3	4.5	5.5	-0.9	2.3	-2.3	-2.3	2.3	2.3
Time to tail flick, vehicle, before self-admin	2.8	2.8	3.7	0.4	-1.9	1.9	1.9	-1.9	-1.5
Time to tail flick, vehicle, after self-admin	1.7	1.8	2.7	-0.6	-1.4	1.4	1.4	-1.4	-1.6
Time to tail flick, test, before self-admin	0.3	0.3	0.8	0.9	0.4	-0.4	-0.4	0.4	0.4
Time to tail flick, test, after self-admin	0.2	0.3	0.3	0.5	-0.5	0.5	0.5	-0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.7	-1.7	1.0	-1.0	-1.0	1.0	0.5
Delta time to tail flick, test, before/after SA	1.2	1.1	1.3	-0.0	-1.1	1.1	1.1	-1.1	-1.1
Tibia length	0.9	2.7	3.4	0.1	-1.8	1.8	1.8	-1.8	-1.8
Ambulatory time before self-admin	1.9	2.0	2.7	0.8	-1.5	1.5	1.5	-1.5	-1.6
Ambulatory time after self-admin	0.5	0.5	0.9	0.2	-0.7	0.7	0.7	-0.7	-0.9
Bone: tissue strength	2.2	2.1	2.4	1.0	-1.5	1.5	1.5	-1.5	-1.5
Total heroin consumption	0.5	0.6	1.4	0.0	-0.8	0.8	0.8	-0.8	-1.2
Bone: trabecular number	1.0	1.5	3.0	-1.7	-1.1	1.1	1.1	-1.1	-1.0
Bone: trabecular spacing	0.5	0.6	0.8	0.9	0.8	-0.8	-0.8	0.8	0.7
Bone: trabecular thickness	0.4	0.5	2.9	-1.7	-0.1	0.1	0.1	-0.1	-0.2
Bone: trabecular tissue density	0.4	0.6	0.7	0.7	-0.8	0.8	0.8	-0.8	-0.8
Water consumed over 24 hours	1.0	1.2	1.4	-0.7	1.2	-1.2	-1.2	1.2	1.2
Number of responses in last shaping day	0.0	0.0	0.2	-0.4	-0.0	0.0	0.0	-0.0	-0.2