Hub : Genes

LOC120095188

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr10_90474854_90527932	0.04	0.03	3.9e-04	0.02	0.04	0.03	0.03	4.5e-03	2.8e-04	6.8e-04	7.1e-04
2	NAcc	intron excision ratio	chr10_90493678_90497362	0.03	0.02	6.7e-03	0.01	0.01	-0	0.01	3.0e-02	1.1e-02	4.3e-01	4.6e-02
3	Brain	gene expression	LOC120095188	0.06	0.03	2.4e-04	0.01	0.03	0.03	0.02	7.3e-02	8.5e-04	1.9e-03	6.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.5	0.9	1.4	1.1	-0.1	-1.2
Area under the delay curve	0.5	0.5	1.0	0.3	-1.0	0.7
BMI with tail	3.5	11.4	17.8	0.5	-4.0	4.2
BMI without tail	4.6	9.4	16.3	0.9	-3.3	4.0
Body weight	4.1	17.4	22.0	3.1	-4.7	4.6
Weight adjusted by age	0.3	0.4	0.6	0.2	-0.7	0.8
Bone surface	3.3	5.8	13.9	3.7	-1.8	-0.4
Bone volume	2.3	3.9	9.0	3.0	-1.6	-0.3
Breakpoint value in progressive ratio session	0.4	0.4	1.3	1.2	0.1	-0.0
Number of licking bursts	0.1	0.2	0.4	0.6	-0.4	-0.0
Context. condit. distance diff. score	0.3	0.3	0.6	-0.6	-0.2	0.8
Locomotion velocity, session 1	0.4	0.4	1.0	1.0	0.0	-0.5
Locomotion distance, session 1	0.0	0.1	0.1	-0.0	0.2	-0.3
Locomotion velocity, session 2	1.9	2.2	3.6	1.0	1.4	-1.9
Locomotion distance, session 2	0.7	1.0	1.6	-0.1	1.3	-1.2
Locomotion velocity, session 3	0.2	0.3	0.6	0.2	0.4	-0.8
Locomotion distance, session 3	0.3	0.4	0.6	0.7	0.0	-0.8
Stereotopy head waving bouts, day 3	0.5	0.6	0.8	-0.9	0.7	-0.7
Stereotopy head waving duration, day 3	0.4	0.4	1.0	-1.0	0.6	-0.1
Locomotion velocity, session 7	0.5	0.5	0.6	-0.6	0.7	-0.8
Locomotion distance, session 7	0.1	0.1	0.3	-0.6	0.3	-0.1
Stereotopy head waving bouts, day 7	1.3	1.4	2.3	-0.6	1.2	-1.5
Stereotopy head waving duration, day 7	3.9	4.7	6.4	-1.4	2.5	-2.4
Locomotion velocity, session 8	0.8	0.9	1.4	1.2	-0.6	1.0
Locomotion distance, session 8	0.3	0.4	0.9	-0.7	0.9	-0.1
Degree of sensitization distance	0.6	0.6	1.3	-0.7	-0.3	1.1
Degree of sensitization stereotypy	2.0	2.2	3.6	-0.6	1.6	-1.9
Conditioned locomotion	0.1	0.1	0.2	-0.4	0.1	0.4
Cocaine response after cond. corrected	0.8	0.9	1.9	0.9	-1.4	0.3
Cocaine response after cond. not corrected	1.0	1.1	1.6	1.3	-0.6	-1.1
Cocaine response before conditioning	1.8	2.2	4.3	0.3	1.4	-2.1
Saline control response	0.4	0.5	1.3	0.4	-0.3	1.1
Bone: connectivity density	0.8	1.2	1.9	1.3	0.1	-1.4
Bone: cortical apparent density	5.0	6.6	13.0	-3.6	2.3	-1.1
Bone: cortical area	2.4	3.6	5.3	2.2	-2.3	0.8
Bone: cortical porosity	12.9	14.1	33.2	5.8	-3.0	0.1
Bone: cortical porosity	10.1	11.0	23.6	4.9	-3.0	0.5
Bone: cortical thickness	0.6	1.0	2.0	-1.4	-0.1	-0.9
Bone: cortical thickness	1.8	2.1	4.2	-1.0	1.0	-2.0
Bone: cortical tissue density	5.0	6.6	12.8	-3.6	2.4	-1.1
Condit. Reinf. active minus inactive responses	0.9	1.1	2.9	1.7	-0.5	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.0	1.0	-0.1	-0.3
Condit. Reinf. active responses	0.7	0.9	2.4	1.6	-0.3	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.4	-0.1	0.5
Incentive salience index mean	0.9	1.1	2.9	1.7	-0.1	-0.6
Condit. Reinf. lever presses	0.6	0.8	1.4	0.6	0.8	-1.2
Condit. Reinf. active minus inactive responses	2.1	2.7	7.2	2.7	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	2.1	2.2	5.6	2.4	-0.5	-0.9
Condit. Reinf. active responses	1.6	2.2	6.3	2.5	-0.6	0.0
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.4	0.2	0.6
Condit. Reinf. lever presses	0.6	0.9	2.4	1.6	-0.2	-0.4
Condit. Reinf. lever reinforcers received	1.5	2.1	5.7	2.4	-0.7	0.0
Conditioned reinforcement - actives	0.8	0.8	1.6	0.3	-0.8	1.3
Conditioned reinforcement - inactives	1.0	1.1	1.6	0.9	-1.3	1.0
Conditioned locomotion	2.0	2.4	2.9	1.5	-1.7	1.4
Patch foraging indifference point 0 sec	0.5	0.9	1.4	0.9	-0.7	1.2
Patch foraging indifference point AUC	0.7	0.8	1.8	0.3	-0.7	1.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.7	0.6	-0.5
Delay disc. indifference point, 16s delay	2.1	2.2	3.7	0.9	-1.9	1.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	0.2	-0.2
Delay disc. indifference point, 24s delay	3.0	2.9	4.5	0.8	-1.9	2.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.7	-0.3	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.8	0.0	-0.1
Indifference point function ln k	0.3	0.4	1.0	-0.0	0.4	-1.0
Indifference point function log k	0.3	0.4	1.0	-0.0	0.4	-1.0
Patch foraging total patch changes 0 sec	0.9	1.5	1.7	1.3	-1.0	1.3
Patch foraging total patch changes 12 sec	0.3	0.4	1.1	0.4	0.1	1.1
Patch foraging total patch changes 18 sec	1.5	1.9	2.3	1.5	-1.3	1.2
Patch foraging total patch changes 24 sec	0.7	0.8	1.1	1.1	-0.7	0.9
Patch foraging total patch changes 6 sec	0.7	1.0	1.4	1.2	-0.9	0.9
Patch foraging time to switch 0 sec	0.3	0.5	1.0	0.2	0.6	-1.0
Patch foraging water rate 0 sec	1.2	1.9	2.6	0.9	-1.6	1.5
Patch foraging water rate 12 sec	0.2	0.2	0.7	0.1	-0.8	-0.3
Patch foraging water rate 18 sec	0.4	0.5	1.4	-0.1	0.5	-1.2
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.1	-0.2	-0.3
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.2	-0.5	-0.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.1	0.0	-0.6	1.0
Distance traveled before self-admin	1.5	1.6	2.9	1.7	-1.3	0.2
Distance traveled after self-admin	1.0	1.1	1.8	1.3	-1.2	0.3
Extensor digitorum longus weight	2.0	7.7	14.6	-2.5	-1.5	3.8
Bone: elastic displacement	0.3	0.4	1.0	-0.3	0.1	-1.0
Bone: elastic work	0.4	0.6	0.9	0.8	-1.0	-0.1
Bone: endosteal estimation	7.6	16.6	36.2	6.0	-3.3	1.6
Bone: endosteal perimeter	12.0	24.9	43.4	6.6	-4.7	3.0
Epididymis fat weight	2.1	4.9	7.6	1.1	-2.4	2.7
Delta time in closed arm before/after self-admin	0.4	0.3	0.9	0.3	0.1	-1.0
Delta time in open arm before/after self-admin	1.1	1.0	2.1	-1.4	0.6	0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.2	0.0	0.1
Delay discount exponential model param	0.7	0.7	1.2	-0.5	1.1	-0.8
Extinction: sum of active levers before priming	0.3	0.3	0.9	0.0	-0.3	0.9
Active lever presses in extinction session 6	1.9	1.9	3.2	1.8	-1.3	0.8
Bone: final force	0.8	1.3	2.1	1.4	-1.3	-0.2
Bone: final moment	0.9	1.4	2.5	1.6	-1.3	-0.3
Food consumed during 24 hour testing period	3.1	3.8	5.9	1.3	-1.9	2.4
Glucose	0.0	0.0	0.1	0.0	-0.3	0.2
Heart weight	1.5	2.1	3.2	0.8	-1.8	1.6
Delay discount hyperbolic model param	0.3	0.3	0.6	-0.4	0.8	-0.5
Intermittent access intake day 1-15 change	0.8	0.8	1.4	1.2	-0.9	0.5
Intermittent access intake escalation	0.2	0.2	0.4	0.6	-0.4	0.2
Intermittent access intake escalation 2	0.6	0.6	1.1	1.1	-0.7	0.4
Intermitt. access day 1 inactive lever presses	1.7	1.8	4.6	2.2	-0.8	-0.2
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.7	1.6	-1.0	0.2
Intermitt. access escalation Index	0.6	0.5	0.7	-0.8	0.6	-0.7
Intermittent access day 1 total infusions	1.2	1.4	2.0	0.6	-1.4	1.4
Intermittent access day 15 total infusions	1.5	1.7	2.8	0.5	-1.4	1.7
Intermittent access terminal intake (last 3 days)	2.2	2.4	3.0	1.2	-1.6	1.7
Intermittent access total infusions	1.8	2.0	2.7	1.1	-1.4	1.6
Intermittent access day 1 locomotion	3.8	3.9	4.9	1.7	-2.2	2.0
Intermittent access day 15 total locomotion	2.7	2.9	3.4	1.5	-1.7	1.9
Intermittent access total locomotion	4.2	4.8	5.1	2.2	-2.3	2.1
Intermittent access standard deviation	0.8	0.9	1.2	1.1	-0.9	0.7
Left kidney weight	0.2	0.5	1.3	0.1	-1.1	0.4
Right kidney weight	0.1	0.2	0.4	0.4	-0.7	-0.3
Cocaine induced anxiety	0.2	0.3	0.7	0.3	-0.9	-0.1
Post-drug Anxiety	0.8	0.9	2.0	0.8	-1.4	0.2
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.1	-0.1
Tail length	0.8	2.4	3.8	2.0	-1.2	1.5
Length with tail	1.2	4.2	8.5	2.9	-1.7	1.2
Length without tail	0.4	0.8	2.0	1.4	-0.4	-0.4
Times rat made contact with spout	0.5	0.6	0.9	0.9	-0.8	0.5
Lifetime Intake	1.4	1.6	2.0	1.1	-1.3	1.4
Liver weight, left	0.2	0.4	0.6	0.5	0.8	-0.6
Liver weight, right	0.2	0.4	1.0	-1.0	0.1	-0.5
Locomotor activity	0.1	0.1	0.2	0.4	0.5	-0.2
Locomotor testing distance	0.3	0.5	1.3	1.1	-0.1	0.4
Locomotor testing rearing	0.2	0.4	1.0	1.0	0.3	-0.0
Locomotion in novel chamber	0.8	1.0	2.0	1.4	-1.0	-0.1
Locomotion in novel chamber post-restriction	0.8	1.0	1.1	1.0	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.4	0.4	0.8	0.0	-0.6	0.9
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	-0.3	-0.8	0.8
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.3	-0.7	0.7	-1.1
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.8	0.1	-0.0
Total resting periods, locomotor time 1	0.2	0.2	0.6	-0.8	0.0	-0.1
Rest time, locomotor task time 1	1.2	1.3	1.6	-1.0	1.2	-1.3
Distance moved, locomotor task time 1	0.9	1.0	1.3	0.9	-1.1	1.0
Vertical activity count, locomotor time 1	0.9	1.0	1.4	1.2	-1.1	0.5
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.5	1.2	-0.1	-1.2
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.1	-0.3	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	-0.1	0.1
Rest time, locomotor task time 2	0.9	1.1	2.6	-1.6	0.7	-0.4
Distance moved, locomotor task time 2	0.4	0.5	1.2	1.1	-0.2	-0.5
Vertical activity count, locomotor time 2	0.7	0.7	2.0	1.4	-0.2	-0.3
Light reinforcement 1	0.3	0.5	0.8	-0.9	0.6	0.6
Light reinforcement 2	0.2	0.2	0.4	-0.6	0.5	0.1
Bone: marrow area	7.5	16.3	35.8	6.0	-3.3	1.5
Bone: maximum diameter	4.7	8.5	15.7	4.0	-3.0	1.1
Bone: maximum force	2.0	3.4	5.5	1.9	-2.3	1.0
Bone: maximum moment	2.0	3.4	5.2	2.0	-2.3	0.9
Mean time between licks in bursts	1.8	2.6	3.8	0.6	-2.0	1.9
Mean num. licks in bursts	0.2	0.3	0.6	-0.2	-0.4	0.8
Cd content in liver	2.4	2.6	5.1	-2.3	1.5	-0.7
Co content in liver	0.4	0.4	0.8	-0.7	0.9	-0.1
Cu content in liver	0.0	0.0	0.1	0.1	0.3	-0.1
Fe content in liver	1.7	2.0	3.0	-1.0	1.7	-1.4
K content in liver	0.4	0.4	0.6	0.4	0.8	-0.6
Mg content in liver	2.4	2.4	4.2	-1.4	2.0	-1.1
Mn content in liver	3.2	3.6	5.4	-1.0	2.3	-2.1
Na content in liver	0.7	0.7	1.3	0.2	1.1	-0.9
Rb content in liver	5.0	6.2	8.9	-2.3	3.0	-2.1
Se content in liver	1.1	1.3	3.0	-1.7	0.9	-0.2
Sr content in liver	1.6	1.4	2.4	1.3	-1.5	0.5
Zn content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.1
Bone: minimum diameter	10.3	19.3	29.7	5.5	-4.5	2.9
Time in familiar zone, hab. session 1	0.7	0.7	1.6	0.3	-0.6	1.3
Time in novel zone, hab. session 1	0.5	0.5	1.2	-0.3	0.3	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.5	0.2	-0.6	0.7
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.8	-0.4	-0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.8	0.9	-0.4	-0.1
Time in familiar zone, hab. session 2	0.5	0.5	0.9	0.6	-0.4	0.9
Time in novel zone, hab. session 2	0.6	0.6	1.3	-0.6	0.3	-1.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.5	0.4	0.3
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	0.6	0.1
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.9	0.5	0.2
Novel to familiar place preference ratio	0.9	1.0	1.6	0.9	-1.3	0.8
Novelty place preference	0.5	0.5	0.8	0.7	-0.9	0.4
Time in novel zone, NPP test	0.4	0.4	0.6	0.7	-0.8	0.1
Total zone transitions, NPP test	0.2	0.3	0.6	-0.8	0.7	-0.1
Total locomotion distance, NPP test	0.2	0.2	0.4	-0.2	0.6	-0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.5	0.1	0.3
Intraocular pressure	3.8	5.3	8.0	1.1	-2.6	2.8
Delta distance traveled before/after self-admin	0.4	0.4	0.4	-0.6	0.6	-0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	-0.6	0.6	-0.5
Parametrial fat weight	0.5	0.9	1.4	1.2	-1.1	0.4
Pavlov. Cond. lever latency	1.3	1.6	4.2	-2.1	0.5	0.6
Pavlov. Cond. magazine entry latency	1.2	1.6	4.4	2.1	-0.3	-0.4
Pavlov. Cond. change in total contacts	1.2	1.3	3.5	1.9	-0.1	-0.5
Pavlov. Cond. index score	1.3	1.6	4.5	2.1	-0.5	-0.4
Pavlov. Cond. latency score	1.1	1.4	3.9	2.0	-0.5	-0.3
Pavlov. Cond. lever contacts	1.3	1.5	4.1	2.0	-0.6	-0.4
Pavlov. Cond. magazine entry number	0.8	1.0	2.4	-1.6	-0.2	0.8
Pavlov. Cond. intertrial magazine entries	1.3	1.6	4.1	-0.0	-0.8	2.0
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	5.1	2.3	-0.7	-0.3
Pavlov. Cond. response bias	1.7	2.1	5.3	2.3	-0.2	-1.0
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	-0.2	0.3
Pavlov. Cond. magazine entry latency	0.7	0.9	1.2	-0.7	1.1	-0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.2	0.8	-0.2
Pavlov. Cond. index score	0.2	0.3	0.3	0.6	0.4	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.6	0.7	0.4	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.3	-0.3
Pavlov. Cond. magazine entry number	1.3	1.6	1.9	1.0	-1.4	1.4
Pavlov. Cond. intertrial magazine entries	7.0	9.2	9.7	3.1	-3.1	2.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.4	0.4	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	0.1	0.5	-0.5
Time in closed arm before self-admin	1.6	1.8	2.4	-0.9	1.6	-1.5
Time in closed arm after self-admin	1.8	1.8	3.1	-0.5	1.4	-1.8
Time in open arm before self-admin	1.0	1.1	2.4	0.9	-1.6	0.4
Time in open arm after self-admin	2.8	3.0	4.9	0.6	-2.0	2.2
Bone: periosteal estimation	6.6	13.6	26.9	5.2	-3.5	1.4
Bone: periosteal perimeter	6.8	11.3	19.6	4.4	-3.5	1.3
Bone: post-yield work	3.6	5.0	6.6	2.6	-2.5	1.5
Progressive ratio test 1 active lever presses	2.0	2.1	2.6	1.6	-1.4	1.3
Progressive ratio test 1 breakpoint	2.9	3.0	3.2	1.8	-1.7	1.7
Progressive ratio test 1 inactive lever presses	1.5	1.7	2.3	1.5	-1.2	1.2
Progressive ratio test 2 active lever presses	2.5	2.7	2.9	1.5	-1.7	1.7
Progressive ratio test 2 breakpoint	3.9	4.3	4.8	2.1	-2.2	1.9
Progressive ratio test 2 inactive lever presses	1.9	2.1	3.4	0.9	-1.5	1.9
Incentive Sensitization - Responses	1.8	1.8	2.0	1.3	-1.4	1.4
Incentive Sensitization - Breakpoint	1.7	1.7	1.8	1.3	-1.4	1.3
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.3	-1.2	1.0	0.1
Progressive ratio	0.0	0.1	0.1	0.1	-0.2	0.3
Food seeking constrained by brief footshock	1.0	1.2	2.3	1.5	-0.6	1.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.7	0.8	-0.3	0.3
Retroperitoneal fat weight	0.7	2.2	2.5	1.4	-1.4	1.6
Reaction time number correct	0.1	0.1	0.2	-0.3	-0.5	0.3
Reaction time mean minus median	0.1	0.1	0.2	-0.4	0.3	-0.3
Reaction time mean minus median AUC	1.0	1.4	2.0	-1.4	1.1	-0.9
Reaction time num false alarms	2.4	3.2	5.9	2.4	-1.7	1.0
Reaction time num false alarms AUC	1.9	2.6	4.9	2.2	-1.4	0.9
Reaction time trials correct on left	0.1	0.1	0.2	-0.3	-0.5	0.3
Reaction time trials on left	0.1	0.1	0.3	-0.3	-0.5	0.3
Reaction time mean	2.2	3.1	4.1	-1.1	2.0	-2.0
Reaction time mean AUC	2.9	3.9	5.1	-1.2	2.2	-2.3
Median of all reaction times	2.7	3.8	5.2	-1.1	2.2	-2.3
Reaction time omissions	0.2	0.2	0.7	0.2	0.2	-0.8
Reaction time false alarm rate	1.5	2.0	4.9	2.2	-1.0	0.5
Reaction time premature initiation rate	0.7	0.9	1.5	0.6	-1.0	1.2
Reaction time premature initiations	0.8	1.1	1.9	0.3	-1.1	1.4
Std. dev. reaction times	0.9	1.2	1.5	-0.9	1.2	-1.2
Reaction time trials completed	0.1	0.1	0.3	-0.3	-0.5	0.3
Reaction time trials AUC	0.1	0.1	0.2	-0.4	-0.4	0.3
Run reversals in cocaine runway, females	1.4	1.3	3.0	0.7	-1.7	0.7
Run reversals in cocaine runway, males	0.6	0.5	0.9	0.8	-1.0	0.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	-0.1	-0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.6	-0.7	-0.3
Latency to leave start box in cocaine runway, M	0.8	0.8	1.3	-0.9	1.1	-0.4
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.3	-0.5	0.7
Total sessions with >9 infusions	0.3	0.3	0.6	-0.6	-0.1	0.7
Short access day 1 total inactive lever presses	0.9	1.0	1.5	1.2	-1.2	0.3
Short access day 10 total inactive lever presses	0.4	0.5	0.6	0.5	-0.8	0.7
Short access day 1 total infusions	0.4	0.5	1.1	0.1	-0.5	1.0
Short access day 10 total infusions	3.0	3.3	3.5	1.9	-1.8	1.8
Short access total infusions	1.0	1.1	1.6	1.3	-0.9	1.0
Short access day 1 locomotion	3.4	3.6	5.4	1.1	-2.1	2.3
Short access day 10 total locomotion	5.9	6.6	7.0	2.6	-2.5	2.5
Short access total locomotion	3.7	3.8	4.6	1.7	-2.0	2.2
One hour access (0.3 mA shock)	0.9	1.0	1.1	1.0	-1.0	0.9
Compulsive drug intake	0.3	0.3	0.8	0.1	0.1	-0.9
One hour access (shock baseline)	0.7	0.8	1.4	0.6	-0.7	1.2
Social response proportion	1.0	1.1	1.8	0.2	-1.3	1.2
Social responses	0.1	0.2	0.3	0.3	-0.4	0.6
Social time	1.3	1.7	2.8	1.1	-1.7	1.1
Soleus weight	0.7	2.2	3.2	1.4	-1.8	1.1
Bone: stiffness	0.3	0.4	0.5	0.7	-0.7	0.5
Tibialis anterior weight	1.4	4.7	10.6	-0.1	-1.9	3.3
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.0	1.0	-0.9	-0.4
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	0.4	-0.5	0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.3	0.0	-0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.1	0.5	0.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.1	0.7	-0.4
Tibia length	0.1	0.4	0.8	0.5	-0.9	-0.1
Ambulatory time before self-admin	1.6	1.7	2.9	1.7	-1.4	0.4
Ambulatory time after self-admin	1.0	1.1	2.0	1.4	-1.1	0.0
Bone: tissue strength	0.4	0.4	0.9	-0.9	0.4	-0.5
Total heroin consumption	0.5	0.6	1.1	1.1	0.1	-0.8
Bone: trabecular number	0.7	1.2	2.2	1.5	-0.2	-1.1
Bone: trabecular spacing	0.5	0.6	0.9	-1.0	0.1	0.9
Bone: trabecular thickness	2.1	2.6	4.9	2.2	-1.7	0.1
Bone: trabecular tissue density	0.4	0.5	1.5	-1.2	0.3	-0.2
Water consumed over 24 hours	0.1	0.1	0.2	0.1	-0.4	0.2
Number of responses in last shaping day	3.2	3.3	4.8	2.2	-2.1	0.9