LOC120095141

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC120095141	0.07	0.05	1.1e-03	0.02	0.04	0.03	0.03	2.5e-02	4.1e-03	1.1e-02	6.8e-03
2	PL	gene expression	LOC120095141	0.24	0.13	2.0e-10	0.09	0.1	0.1	0.09	3.3e-10	9.3e-11	1.5e-10	2.8e-10
3	PL	mRNA stability	LOC120095141	0.03	0.02	1.3e-04	0.04	0.03	0.02	0.03	8.9e-05	2.9e-04	3.0e-03	2.3e-04
4	BLA	mRNA stability	LOC120095141	0.04	0.03	5.9e-03	0.02	0.02	0	0.02	2.5e-02	2.7e-02	3.1e-01	4.6e-02
5	IC	intron excision ratio	chr10_61333356_61336973	0.06	0.04	4.5e-03	0.06	0.05	0.04	0.05	2.1e-03	5.4e-03	9.9e-03	3.1e-03
6	IL	mRNA stability	LOC120095141	0.16	0.1	8.1e-04	0.11	0.13	0.09	0.09	1.6e-03	6.2e-04	3.7e-03	3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.7	5.0	7.1	-2.7	-2.5	2.0	2.1	2.1	-1.9
Area under the delay curve	0.6	1.0	1.5	1.2	1.1	-0.9	-0.8	-1.0	0.8
BMI with tail	0.3	1.2	2.2	-1.5	-0.7	1.4	1.0	0.8	-0.9
BMI without tail	1.0	5.1	6.3	-2.2	-1.7	2.4	2.5	2.4	-2.3
Body weight	3.0	13.1	15.3	-3.4	-3.1	3.9	3.8	3.6	-3.8
Weight adjusted by age	0.0	0.0	0.0	-0.2	0.1	0.0	0.0	0.0	0.2
Bone surface	1.3	2.7	4.4	-2.1	-1.6	1.6	1.5	1.5	-1.3
Bone volume	1.4	2.9	4.8	-2.2	-1.9	1.6	1.5	1.5	-1.4
Breakpoint value in progressive ratio session	1.1	2.0	2.3	-1.4	-1.3	1.5	1.4	1.5	-1.4
Number of licking bursts	0.1	0.3	0.5	0.6	-0.0	-0.6	-0.7	-0.7	0.3
Context. condit. distance diff. score	1.1	1.3	2.5	-1.4	-1.6	1.0	0.7	0.8	-1.1
Locomotion velocity, session 1	3.5	4.0	4.8	-2.2	-2.0	2.1	1.8	1.9	-2.0
Locomotion distance, session 1	0.1	0.1	0.3	-0.5	-0.3	0.4	0.4	0.4	-0.2
Locomotion velocity, session 2	0.4	0.4	0.7	-0.8	-0.6	0.6	0.6	0.7	-0.5
Locomotion distance, session 2	0.6	0.8	1.1	-1.1	-0.7	0.8	1.0	1.1	-0.5
Locomotion velocity, session 3	2.0	2.3	4.0	2.0	2.0	-1.2	-1.3	-1.3	1.1
Locomotion distance, session 3	0.4	0.5	1.4	0.6	1.2	-0.5	-0.5	-0.5	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	0.6	-0.5	-0.7	0.8	0.6	0.7	-0.8
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.5	0.2	-0.4	-0.7	-0.7	0.3
Locomotion velocity, session 7	0.1	0.1	0.3	-0.5	0.0	0.4	0.2	0.3	-0.1
Locomotion distance, session 7	0.3	0.3	0.8	-0.9	-0.4	0.6	0.5	0.6	-0.3
Stereotopy head waving bouts, day 7	0.9	1.1	1.4	-1.1	-1.1	1.2	0.9	0.9	-1.0
Stereotopy head waving duration, day 7	0.8	1.0	1.3	-1.1	-1.1	1.2	0.8	0.9	-0.9
Locomotion velocity, session 8	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.2	-0.1	0.1
Locomotion distance, session 8	1.7	2.5	3.5	-1.9	-1.7	1.5	1.4	1.4	-1.5
Degree of sensitization distance	1.7	1.8	2.6	-1.4	-1.6	1.2	1.3	1.3	-1.2
Degree of sensitization stereotypy	1.3	1.5	1.8	-1.3	-1.3	1.3	1.1	1.1	-1.2
Conditioned locomotion	0.3	0.3	0.5	0.6	0.3	-0.6	-0.7	-0.6	0.5
Cocaine response after cond. corrected	0.5	0.7	1.1	-0.8	-1.1	0.7	0.8	0.7	-0.9
Cocaine response after cond. not corrected	0.7	1.0	1.4	-1.0	-1.2	0.8	1.0	0.9	-1.1
Cocaine response before conditioning	0.2	0.3	0.6	-0.8	-0.3	0.6	0.4	0.5	-0.5
Saline control response	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.2	-0.2	0.3
Bone: connectivity density	3.2	5.1	7.5	-2.7	-2.3	2.1	2.3	2.3	-1.8
Bone: cortical apparent density	0.8	1.2	1.8	1.0	0.9	-1.3	-1.1	-1.1	1.2
Bone: cortical area	1.0	1.6	3.4	1.6	1.8	-1.0	-0.9	-0.9	1.1
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	0.4	0.3	0.2	-0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	-0.1	-0.1
Bone: cortical thickness	2.0	3.3	5.9	2.4	2.4	-1.5	-1.5	-1.4	1.3
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.5	0.1	-0.2	-0.1	-0.2
Bone: cortical tissue density	0.5	0.8	1.3	0.8	0.6	-1.1	-0.9	-0.8	1.0
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	0.1	0.2	0.3	0.3	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.4	0.4	0.4	0.5	0.5	-0.5
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	-0.3	0.4	0.4	0.3	-0.3
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.6	-0.6	-0.3	-0.3	-0.4	0.5
Incentive salience index mean	0.1	0.2	0.4	-0.2	0.0	0.6	0.4	0.4	-0.5
Condit. Reinf. lever presses	0.9	1.3	2.0	-1.2	-0.7	1.4	1.1	1.0	-1.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.5	-0.4	0.3	0.5	0.5	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	-0.3	0.4	0.4	0.4	-0.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1	-0.0	0.3
Condit. Reinf. inactive responses	0.3	0.5	1.0	0.1	0.6	-0.8	-0.7	-0.8	1.0
Condit. Reinf. lever presses	1.7	2.4	2.8	1.4	1.6	-1.5	-1.6	-1.7	1.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.0	0.3	-0.3	-0.1	-0.2	0.5
Conditioned reinforcement - actives	0.1	0.3	0.7	-0.9	-0.6	0.5	0.5	0.4	-0.2
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.4	-0.2	0.1	0.2	0.1	-0.1
Conditioned locomotion	0.8	1.2	2.2	1.1	1.5	-0.8	-0.9	-0.9	1.2
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	0.4	0.1	-0.1	-0.2	0.1
Patch foraging indifference point AUC	0.2	0.6	0.8	0.7	0.5	-0.9	-0.8	-0.8	0.9
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.3	-0.4	0.3	0.6	0.5	-0.3
Delay disc. indifference point, 16s delay	0.6	0.9	1.3	1.1	0.8	-0.9	-1.0	-1.0	0.8
Delay disc. indifference point, 2s delay	0.6	0.7	0.9	1.0	0.7	-0.9	-0.8	-0.9	0.7
Delay disc. indifference point, 24s delay	0.2	0.4	0.5	0.6	0.7	-0.6	-0.5	-0.6	0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.6	0.3	-0.4	-0.1	-0.4	0.2
Delay disc. indifference point, 8s delay	0.3	0.5	0.6	0.8	0.7	-0.6	-0.7	-0.8	0.5
Indifference point function ln k	0.1	0.4	0.7	-0.8	-0.5	0.7	0.5	0.5	-0.6
Indifference point function log k	0.1	0.4	0.7	-0.8	-0.5	0.7	0.5	0.5	-0.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.1	0.4	0.1	-0.1	-0.2	0.2
Patch foraging total patch changes 12 sec	0.1	0.2	0.6	0.6	0.8	-0.3	-0.2	-0.3	0.3
Patch foraging total patch changes 18 sec	0.0	0.1	0.3	0.6	0.4	-0.2	-0.2	-0.3	0.1
Patch foraging total patch changes 24 sec	0.2	0.5	1.0	0.9	1.0	-0.7	-0.4	-0.6	0.7
Patch foraging total patch changes 6 sec	0.7	1.3	1.7	0.9	1.1	-1.0	-1.3	-1.3	1.1
Patch foraging time to switch 0 sec	0.0	0.2	0.5	0.0	-0.3	0.4	0.4	0.4	-0.7
Patch foraging water rate 0 sec	0.2	0.6	1.1	0.5	0.8	-0.8	-0.6	-0.7	1.1
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	-0.1	-0.0
Patch foraging water rate 18 sec	0.4	1.0	1.8	-1.3	-1.3	1.0	0.7	0.7	-0.7
Patch foraging water rate 24 sec	0.2	0.2	0.3	0.2	0.5	-0.4	-0.6	-0.6	0.5
Patch foraging water rate 6 sec	0.7	1.0	1.4	1.0	1.2	-1.0	-0.7	-0.8	1.1
Seeking ratio, delayed vs. immediate footshock	1.8	2.6	2.8	1.7	1.7	-1.6	-1.5	-1.5	1.6
Distance traveled before self-admin	1.5	3.2	4.7	2.2	1.8	-1.9	-1.6	-1.6	1.7
Distance traveled after self-admin	0.1	0.2	0.4	0.6	0.4	-0.5	-0.4	-0.3	0.4
Extensor digitorum longus weight	1.3	5.4	9.7	-3.1	-2.5	2.0	2.3	2.2	-1.5
Bone: elastic displacement	1.1	1.3	1.7	1.1	0.9	-1.2	-1.3	-1.3	1.1
Bone: elastic work	2.8	3.7	6.8	2.3	2.6	-1.6	-1.7	-1.7	1.5
Bone: endosteal estimation	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	-0.0	0.0
Bone: endosteal perimeter	0.0	0.1	0.2	-0.4	-0.2	-0.1	0.2	0.0	0.3
Epididymis fat weight	4.9	24.5	30.6	-5.5	-5.5	4.7	4.6	4.6	-4.6
Delta time in closed arm before/after self-admin	1.1	1.0	1.6	1.1	0.5	-1.3	-1.0	-1.0	1.1
Delta time in open arm before/after self-admin	0.6	0.7	1.2	-1.0	-0.4	1.1	0.7	0.7	-0.9
Diff in mean of infusions in LGA sessions	1.0	1.8	2.1	-1.4	-1.1	1.4	1.3	1.4	-1.3
Delay discount exponential model param	0.6	0.8	1.2	-1.1	-1.0	0.8	0.6	0.9	-0.7
Extinction: sum of active levers before priming	0.2	0.4	1.0	-1.0	-0.6	0.5	0.4	0.4	-0.4
Active lever presses in extinction session 6	0.8	0.8	1.5	-1.2	-1.0	0.9	0.8	0.8	-0.7
Bone: final force	0.2	0.4	1.6	0.5	1.3	0.4	0.3	0.3	-0.2
Bone: final moment	0.2	0.4	1.8	0.5	1.4	0.3	0.2	0.1	-0.0
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.5	-0.2	0.5	0.4	0.3	-0.3
Glucose	2.7	4.2	6.1	2.5	2.2	-2.2	-1.7	-1.7	1.9
Heart weight	2.5	4.0	5.5	-1.9	-1.6	2.0	2.3	2.3	-1.8
Delay discount hyperbolic model param	0.6	0.8	1.3	-1.1	-1.1	0.8	0.6	0.9	-0.7
Intermittent access intake day 1-15 change	0.2	1.3	1.8	1.0	1.1	-1.3	-1.1	-1.1	1.4
Intermittent access intake escalation	0.3	1.6	2.2	1.1	1.3	-1.3	-1.1	-1.1	1.5
Intermittent access intake escalation 2	1.0	1.6	2.1	1.2	1.1	-1.4	-1.2	-1.3	1.4
Intermitt. access day 1 inactive lever presses	0.3	4.0	5.3	2.1	2.3	-1.9	-1.9	-1.8	2.1
Intermitt. access day 15 inactive lever presses	0.8	4.1	5.2	1.9	1.5	-2.3	-2.2	-2.2	2.1
Intermitt. access escalation Index	1.2	3.8	4.2	-1.6	-2.0	2.0	2.1	2.0	-2.0
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.2	0.1	-0.2	-0.4	-0.5	0.1
Intermittent access day 15 total infusions	0.2	0.5	0.8	0.5	0.7	-0.7	-0.7	-0.8	0.9
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.0	-0.2	0.2
Intermittent access total infusions	0.3	0.4	0.6	0.4	0.5	-0.6	-0.6	-0.8	0.6
Intermittent access day 1 locomotion	0.2	0.4	0.9	0.7	0.9	-0.4	-0.5	-0.6	0.4
Intermittent access day 15 total locomotion	0.2	0.7	1.0	0.9	1.0	-0.8	-0.6	-0.7	0.9
Intermittent access total locomotion	0.4	0.5	1.0	0.7	1.0	-0.7	-0.4	-0.6	0.8
Intermittent access standard deviation	0.5	2.6	3.4	1.2	1.3	-1.8	-1.7	-1.7	1.8
Left kidney weight	0.0	0.4	1.0	1.0	0.9	0.2	0.4	0.2	-0.4
Right kidney weight	0.1	0.5	1.0	0.4	0.3	0.7	0.9	0.8	-1.0
Cocaine induced anxiety	0.1	0.2	0.5	0.4	0.1	-0.5	-0.6	-0.7	0.4
Post-drug Anxiety	1.1	1.2	2.2	-1.1	-1.5	1.0	1.0	0.7	-1.2
Baseline Anxiety	1.3	2.2	2.6	-1.5	-1.6	1.4	1.5	1.4	-1.5
Tail length	2.0	10.7	13.6	-2.6	-2.8	3.2	3.7	3.6	-3.5
Length with tail	2.6	11.3	13.9	-2.6	-3.1	3.3	3.6	3.6	-3.7
Length without tail	0.7	3.7	4.7	-1.8	-2.1	2.0	1.8	1.7	-2.2
Times rat made contact with spout	0.2	0.2	0.8	0.6	0.9	0.1	0.1	0.1	-0.1
Lifetime Intake	0.3	0.4	0.7	0.4	0.6	-0.6	-0.7	-0.8	0.6
Liver weight, left	8.5	14.7	17.2	-3.6	-3.9	3.8	3.8	3.8	-4.1
Liver weight, right	6.5	11.4	13.1	-3.2	-3.4	3.4	3.3	3.2	-3.6
Locomotor activity	0.0	0.1	0.1	-0.2	-0.3	0.3	0.2	0.2	-0.2
Locomotor testing distance	0.0	0.0	0.1	-0.2	-0.3	0.2	0.2	0.2	-0.1
Locomotor testing rearing	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.2	-0.1	0.2
Locomotion in novel chamber	5.6	7.5	8.3	2.5	2.7	-2.9	-2.8	-2.8	2.9
Locomotion in novel chamber post-restriction	0.1	0.2	0.2	0.1	0.4	-0.4	-0.4	-0.5	0.5
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.3	-0.2	0.3	0.3	0.3	-0.3
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1	0.0	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.7	0.0	0.8	0.2	-0.2	-0.0	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.1	-0.1	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3	-0.3	0.0
Rest time, locomotor task time 1	0.5	0.8	1.5	0.6	0.4	-0.8	-1.2	-1.2	0.7
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	0.1	0.1	0.2	0.3	-0.0
Vertical activity count, locomotor time 1	0.0	0.3	0.5	-0.6	-0.2	0.5	0.7	0.7	-0.3
Time >=10cm from walls, locomotor time 2	0.3	0.9	3.1	0.9	1.8	-0.4	-0.6	-0.5	0.7
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.2	-0.3	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	-0.4	0.2	-0.0	-0.2	-0.2
Rest time, locomotor task time 2	0.1	0.2	0.8	-0.4	-0.9	0.1	-0.2	-0.2	-0.2
Distance moved, locomotor task time 2	0.6	0.8	0.9	0.9	0.9	-0.9	-0.9	-1.0	0.9
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.5	0.5	-0.3	-0.2	-0.2	0.3
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.1	0.0
Light reinforcement 2	0.3	0.7	1.6	1.3	1.0	-0.8	-0.5	-0.4	0.5
Bone: marrow area	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	-0.0	0.0
Bone: maximum diameter	0.3	0.6	1.4	0.7	1.2	-0.7	-0.4	-0.6	1.0
Bone: maximum force	0.2	0.4	1.8	0.7	1.3	0.1	0.2	0.1	0.1
Bone: maximum moment	0.2	0.5	2.0	0.8	1.4	-0.0	-0.1	-0.2	0.3
Mean time between licks in bursts	0.2	1.3	1.5	-1.0	-1.2	1.1	1.2	1.2	-1.2
Mean num. licks in bursts	0.1	0.3	0.6	-0.2	0.6	0.7	0.8	0.7	-0.4
Cd content in liver	0.2	0.2	1.0	-0.4	-1.0	-0.4	-0.0	0.1	0.2
Co content in liver	0.1	0.1	0.3	0.3	0.5	-0.2	-0.4	-0.3	0.2
Cu content in liver	0.5	0.6	1.1	1.0	1.0	-0.8	-0.5	-0.5	0.7
Fe content in liver	0.7	0.9	1.2	-0.8	-1.0	0.9	0.8	0.9	-1.1
K content in liver	0.8	0.8	1.6	-0.3	0.1	0.8	1.3	1.3	-0.8
Mg content in liver	0.1	0.1	0.2	0.1	0.5	-0.1	0.3	0.3	0.2
Mn content in liver	0.0	0.0	0.1	-0.1	0.2	-0.3	-0.2	-0.2	0.4
Na content in liver	0.6	0.7	1.3	1.1	1.0	-0.5	-0.7	-0.8	0.4
Rb content in liver	0.7	0.8	1.4	-1.2	-0.8	0.5	1.1	1.1	-0.4
Se content in liver	0.3	0.3	0.6	0.7	0.8	-0.4	-0.4	-0.5	0.4
Sr content in liver	0.1	0.1	0.3	-0.6	-0.4	0.2	-0.1	-0.1	-0.1
Zn content in liver	0.5	0.6	0.8	-0.8	-0.8	0.9	0.6	0.7	-0.9
Bone: minimum diameter	0.0	0.1	0.3	0.5	0.2	-0.1	0.0	-0.1	-0.0
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.1	0.4	-0.6	-0.7	-0.6	0.8
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.1	-0.3	0.3	0.5	0.4	-0.6
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.2	-0.1	-0.4	-0.1	0.0	0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.7	-0.5	-0.9	0.2	0.3	0.3	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.4	-0.6	0.1	0.1	0.1	-0.0
Time in familiar zone, hab. session 2	0.3	0.3	1.0	-0.8	-1.0	0.3	0.1	0.1	-0.3
Time in novel zone, hab. session 2	0.9	0.9	2.4	1.4	1.6	-0.7	-0.3	-0.3	0.6
Total zone transitions, hab. session 2	0.3	0.4	0.5	-0.7	-0.7	0.5	0.6	0.7	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.2	-0.4	-0.5	0.4	0.4	0.4	-0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.3	-0.4	0.3	0.3	0.3	-0.3
Novel to familiar place preference ratio	0.4	0.6	1.0	0.7	1.0	-0.6	-0.6	-0.7	0.9
Novelty place preference	0.1	0.2	0.4	0.3	0.6	-0.2	-0.3	-0.3	0.5
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	0.3	0.0	-0.0	-0.1	0.2
Total zone transitions, NPP test	0.0	0.1	0.1	-0.4	-0.3	-0.0	0.2	0.3	0.1
Total locomotion distance, NPP test	0.1	0.2	0.3	0.2	0.1	-0.6	-0.5	-0.4	0.5
Locomotion velocity, NPP test	0.6	0.9	1.1	0.7	0.6	-1.0	-1.1	-1.0	1.0
Intraocular pressure	0.9	1.5	2.4	1.0	0.7	-1.4	-1.3	-1.3	1.5
Delta distance traveled before/after self-admin	1.9	2.1	2.7	-1.7	-1.3	1.5	1.4	1.4	-1.4
Delta ambulatory time before/after self-admin	1.1	1.9	2.5	-1.6	-1.3	1.4	1.4	1.3	-1.3
Parametrial fat weight	7.5	17.7	22.1	-4.7	-4.5	4.0	4.0	3.9	-4.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.3	-0.2	0.5
Pavlov. Cond. magazine entry latency	0.8	1.1	1.3	-0.9	-0.8	1.1	1.1	1.1	-1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.6	0.5	-0.4	-0.3	-0.4	0.3
Pavlov. Cond. index score	0.6	0.8	1.1	-0.8	-0.5	1.0	0.9	0.9	-1.0
Pavlov. Cond. latency score	0.8	1.0	1.4	-0.8	-0.6	1.2	1.0	1.0	-1.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.1	0.1	0.4	0.3	0.2	-0.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.5	0.5	-0.6	-0.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.5	0.3	-0.7	-0.9	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.7	-0.4	0.9	0.8	0.7	-0.9
Pavlov. Cond. response bias	0.5	0.6	0.7	-0.7	-0.6	0.8	0.8	0.8	-0.8
Pavlov. Cond. lever latency	1.7	2.5	2.9	-1.7	-1.6	1.5	1.6	1.6	-1.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.9	0.8	-0.5	-0.2	-0.1	0.3
Pavlov. Cond. change in total contacts	0.5	1.2	2.4	1.4	1.6	-1.0	-0.7	-0.8	1.0
Pavlov. Cond. index score	1.6	2.5	3.4	1.8	1.7	-1.6	-1.4	-1.4	1.4
Pavlov. Cond. latency score	1.8	3.0	4.0	2.0	1.9	-1.8	-1.5	-1.5	1.6
Pavlov. Cond. lever contacts	0.7	1.1	1.4	1.2	1.1	-0.9	-1.0	-1.1	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	-1.1	-1.1	0.7	0.3	0.2	-0.5
Pavlov. Cond. intertrial magazine entries	0.5	1.0	2.0	-1.4	-1.4	1.0	0.6	0.5	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.4	3.2	1.8	1.7	-1.6	-1.4	-1.4	1.4
Pavlov. Cond. response bias	0.8	1.1	1.6	1.3	1.1	-1.0	-0.9	-0.9	0.8
Time in closed arm before self-admin	1.8	3.1	3.5	-1.8	-1.6	1.9	1.8	1.7	-1.8
Time in closed arm after self-admin	0.0	0.0	0.1	0.4	-0.1	-0.3	-0.1	-0.2	0.1
Time in open arm before self-admin	3.0	3.6	4.4	2.1	1.7	-1.9	-1.9	-2.1	1.7
Time in open arm after self-admin	1.4	1.5	2.6	1.2	1.6	-1.0	-1.1	-1.2	1.1
Bone: periosteal estimation	0.1	0.3	0.7	0.6	0.9	-0.3	-0.3	-0.4	0.4
Bone: periosteal perimeter	0.2	0.4	0.8	0.6	0.9	-0.6	-0.4	-0.5	0.7
Bone: post-yield work	0.8	1.3	1.9	-1.0	-0.9	1.2	1.3	1.4	-1.0
Progressive ratio test 1 active lever presses	0.3	0.5	0.7	0.6	0.6	-0.6	-0.8	-0.8	0.6
Progressive ratio test 1 breakpoint	0.3	0.4	0.7	0.5	0.5	-0.6	-0.7	-0.8	0.6
Progressive ratio test 1 inactive lever presses	1.3	3.3	3.9	1.8	2.0	-1.7	-1.8	-1.8	1.7
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	0.3	0.5	-0.6	-0.6	-0.8	0.8
Progressive ratio test 2 breakpoint	0.3	0.3	0.6	0.2	0.5	-0.5	-0.6	-0.8	0.8
Progressive ratio test 2 inactive lever presses	0.5	1.5	2.0	1.1	1.3	-1.2	-1.1	-1.2	1.4
Incentive Sensitization - Responses	0.0	0.0	0.2	-0.2	-0.0	-0.2	-0.1	-0.2	0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	-0.1	0.3
Sum of active levers in priming session hrs 5-6	3.0	2.8	3.3	-1.8	-1.3	1.8	1.7	1.8	-1.6
Progressive ratio	0.4	1.2	1.9	0.9	1.4	-0.9	-1.0	-1.0	1.1
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.3	-0.3	0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	-0.1	-0.7	0.3	0.4	0.4	-0.6
Retroperitoneal fat weight	0.3	1.1	3.0	-1.1	-1.7	0.8	0.6	0.6	-1.1
Reaction time number correct	0.0	0.1	0.1	-0.3	-0.1	0.4	0.1	0.1	-0.3
Reaction time mean minus median	0.0	0.3	0.9	0.4	0.1	-0.9	-0.4	-0.4	0.7
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.3	-0.5	-0.5	-0.1	-0.1	0.3
Reaction time num false alarms	0.6	1.1	1.7	0.8	0.8	-1.2	-1.1	-1.0	1.3
Reaction time num false alarms AUC	0.5	1.2	1.8	0.9	1.0	-1.2	-1.0	-0.9	1.3
Reaction time trials correct on left	0.0	0.1	0.1	-0.3	-0.1	0.4	0.1	0.1	-0.3
Reaction time trials on left	0.0	0.0	0.1	-0.3	-0.1	0.3	0.1	0.0	-0.3
Reaction time mean	0.0	0.1	0.3	0.1	-0.3	-0.5	0.2	0.2	0.2
Reaction time mean AUC	0.1	0.2	0.8	0.5	0.1	-0.9	-0.2	-0.2	0.6
Median of all reaction times	0.0	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	0.0
Reaction time omissions	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.3	0.4	-0.1
Reaction time false alarm rate	0.6	0.8	1.4	0.8	0.8	-1.0	-0.8	-0.7	1.2
Reaction time premature initiation rate	0.1	0.1	0.3	-0.6	-0.4	0.3	0.4	0.2	-0.2
Reaction time premature initiations	0.0	0.1	0.3	-0.6	-0.3	0.3	0.3	0.1	-0.2
Std. dev. reaction times	0.1	0.3	0.8	0.4	0.3	-0.9	-0.3	-0.4	0.7
Reaction time trials completed	0.0	0.0	0.1	-0.3	-0.1	0.3	0.1	0.0	-0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.2	0.0	0.3	0.1	0.0	-0.2
Run reversals in cocaine runway, females	0.8	0.9	1.4	0.7	0.5	-1.0	-1.2	-1.2	1.0
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.1	-0.2	-0.3	-0.2	-0.2	0.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1	-0.1	0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.2	-0.1	0.5	0.2	0.2	-0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	-0.4	-0.1	-0.1	0.3
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	-0.1	-0.0
Total sessions with >9 infusions	0.5	0.6	0.9	0.5	0.7	-0.8	-1.0	-1.0	0.8
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	0.3	0.2	-0.1	0.0	-0.1
Short access day 10 total inactive lever presses	0.2	1.5	3.0	1.3	1.7	-1.1	-1.0	-1.0	1.2
Short access day 1 total infusions	1.2	2.4	3.2	1.3	1.6	-1.4	-1.7	-1.8	1.5
Short access day 10 total infusions	0.5	0.9	1.2	0.7	0.7	-1.0	-1.1	-1.1	1.0
Short access total infusions	1.2	1.8	2.7	1.1	1.1	-1.2	-1.6	-1.6	1.2
Short access day 1 locomotion	2.0	3.3	4.4	1.8	2.1	-1.6	-1.9	-1.8	1.7
Short access day 10 total locomotion	0.5	2.1	3.6	1.5	1.9	-1.4	-1.2	-1.2	1.5
Short access total locomotion	3.0	4.5	6.1	2.1	2.5	-2.0	-2.0	-2.0	2.1
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.1	-0.3	0.2
Compulsive drug intake	1.0	1.5	2.1	-1.1	-1.0	1.4	1.3	1.2	-1.3
One hour access (shock baseline)	0.1	0.4	0.6	0.5	0.4	-0.7	-0.7	-0.8	0.7
Social response proportion	3.6	4.6	6.1	-2.0	-1.6	2.2	2.5	2.5	-2.1
Social responses	2.2	2.9	4.6	-1.6	-1.1	1.7	2.0	2.2	-1.5
Social time	2.4	3.8	4.3	-2.0	-1.9	1.9	2.0	2.1	-1.8
Soleus weight	4.8	14.2	15.0	-3.9	-3.7	3.8	3.8	3.8	-3.6
Bone: stiffness	1.4	2.6	3.9	-1.3	-0.8	1.8	2.0	1.9	-1.5
Tibialis anterior weight	2.8	9.7	17.4	-4.2	-3.1	3.0	2.9	2.8	-2.4
Time to tail flick, vehicle, before self-admin	3.2	4.0	5.8	-2.4	-2.1	2.0	1.9	1.9	-1.7
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	-0.5	-0.5	0.4	0.4	0.5	-0.3
Time to tail flick, test, before self-admin	0.9	1.0	1.3	-1.1	-0.8	1.1	1.2	1.0	-1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	-0.1	0.2	0.1	0.0	-0.3
Delta time to tail flick, vehicle, before/after SA	1.3	1.4	1.6	1.3	1.2	-1.2	-1.2	-1.1	1.1
Delta time to tail flick, test, before/after SA	0.7	0.8	1.1	0.8	0.7	-1.0	-1.0	-1.0	0.9
Tibia length	0.5	1.5	2.3	-0.7	-0.6	1.3	1.5	1.4	-1.4
Ambulatory time before self-admin	0.8	2.5	4.1	2.0	1.6	-1.6	-1.4	-1.4	1.3
Ambulatory time after self-admin	0.1	0.2	0.3	-0.1	-0.3	0.4	0.4	0.4	-0.6
Bone: tissue strength	0.8	0.9	2.4	1.3	1.6	-0.7	-0.3	-0.3	0.7
Total heroin consumption	4.1	4.8	5.8	-2.4	-2.0	2.2	2.2	2.3	-2.0
Bone: trabecular number	2.5	4.7	7.1	-2.7	-2.6	1.9	1.9	1.9	-1.9
Bone: trabecular spacing	0.7	1.1	2.3	1.2	1.5	-0.8	-0.7	-0.7	1.0
Bone: trabecular thickness	0.3	0.5	0.6	-0.8	-0.7	0.6	0.6	0.7	-0.6
Bone: trabecular tissue density	1.0	1.8	2.7	1.7	1.3	-1.4	-1.3	-1.2	1.2
Water consumed over 24 hours	0.1	0.1	0.3	-0.0	-0.0	0.5	0.3	0.3	-0.6
Number of responses in last shaping day	3.0	3.9	4.9	1.9	2.2	-1.8	-2.1	-2.0	1.9