Hub : Genes

LOC120094233

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	LOC120094233	0.04	0.02	3.5e-07	0.05	0.04	0.05	0.05	1.4e-08	4.2e-07	4.3e-08	9.5e-08
2	NAcc	gene expression	LOC120094233	0.02	0.01	7.8e-03	0.02	0.02	0.01	0.02	7.3e-04	1.3e-03	6.7e-03	1.4e-03
3	pVTA	gene expression	LOC120094233	0.04	0.03	7.2e-03	0.01	0.01	0	0.01	5.1e-02	7.7e-02	3.2e-01	5.1e-02
4	PL	gene expression	LOC120094233	0.02	0.01	5.0e-03	0.02	0.02	0.01	0.01	2.4e-03	3.7e-03	7.3e-03	9.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.0	3.0	-1.7	1.1	1.4	1.4
Area under the delay curve	0.5	0.6	1.3	-1.1	0.4	0.9	0.5
BMI with tail	7.1	24.6	29.9	5.5	-5.0	-4.6	-4.7
BMI without tail	4.1	12.6	19.0	4.4	-3.3	-3.7	-2.7
Body weight	3.1	13.4	18.1	4.3	-4.0	-3.2	-3.0
Weight adjusted by age	0.4	0.6	1.1	1.0	-1.1	-0.1	0.3
Bone surface	1.4	2.5	4.9	-2.2	1.4	1.3	1.1
Bone volume	1.0	1.8	3.0	-1.7	1.2	1.2	1.1
Breakpoint value in progressive ratio session	0.2	0.2	0.7	-0.1	0.3	0.4	0.8
Number of licking bursts	0.2	0.3	0.4	-0.7	0.5	0.6	0.6
Context. condit. distance diff. score	0.2	0.3	0.6	0.1	-0.8	-0.3	-0.7
Locomotion velocity, session 1	2.2	2.4	3.0	1.7	-1.3	-1.5	-1.7
Locomotion distance, session 1	5.1	6.4	8.6	2.9	-2.3	-2.1	-2.7
Locomotion velocity, session 2	6.8	7.9	10.1	2.8	-2.6	-2.6	-3.2
Locomotion distance, session 2	7.0	9.8	10.6	3.2	-3.0	-3.0	-3.3
Locomotion velocity, session 3	1.1	1.3	2.4	0.8	-1.1	-1.6	-0.9
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	-0.4	-0.5	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	0.1	-0.5	0.3
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.6	-0.4	-0.6	-0.4
Locomotion velocity, session 7	3.5	3.8	5.8	2.4	-2.2	-1.6	-1.5
Locomotion distance, session 7	0.4	0.5	1.0	1.0	-0.5	-0.7	-0.1
Stereotopy head waving bouts, day 7	0.4	0.5	1.7	-1.3	0.3	0.2	0.3
Stereotopy head waving duration, day 7	0.7	0.8	1.8	-1.3	0.7	0.7	0.6
Locomotion velocity, session 8	4.1	5.0	6.2	2.3	-1.8	-2.5	-2.3
Locomotion distance, session 8	2.7	3.9	4.8	1.8	-2.0	-1.8	-2.2
Degree of sensitization distance	0.2	0.2	0.9	0.9	-0.1	-0.1	0.1
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.6	-0.4	-0.4	-0.5
Conditioned locomotion	0.2	0.3	0.6	-0.4	0.8	0.0	0.6
Cocaine response after cond. corrected	0.3	0.4	1.1	0.6	0.2	-1.0	-0.4
Cocaine response after cond. not corrected	0.4	0.4	0.9	0.8	0.3	-0.9	-0.5
Cocaine response before conditioning	0.0	0.1	0.1	0.2	0.3	0.3	-0.0
Saline control response	2.2	2.9	3.9	2.0	-1.5	-1.9	-1.3
Bone: connectivity density	1.4	2.2	4.3	-2.1	1.2	1.1	1.4
Bone: cortical apparent density	0.0	0.0	0.0	0.2	0.2	-0.0	-0.1
Bone: cortical area	2.6	4.0	5.4	2.0	-2.3	-1.9	-1.8
Bone: cortical porosity	0.9	1.0	2.1	1.0	-1.5	-0.7	-0.6
Bone: cortical porosity	1.3	1.4	2.9	1.0	-1.7	-0.7	-1.0
Bone: cortical thickness	1.3	2.1	3.1	1.7	-1.8	-1.1	-1.2
Bone: cortical thickness	0.2	0.2	0.3	0.6	-0.3	0.1	0.5
Bone: cortical tissue density	0.0	0.0	0.0	0.1	0.2	-0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.0	-0.4	0.2	0.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.4	1.4	-1.9	-1.1	-1.0
Condit. Reinf. active responses	0.1	0.2	0.7	0.0	0.0	0.1	0.8
Condit. Reinf. inactive responses	1.4	1.8	2.7	-1.0	1.6	0.9	1.6
Incentive salience index mean	0.4	0.5	1.4	0.6	-1.2	-0.6	-0.2
Condit. Reinf. lever presses	2.6	3.7	4.2	1.9	-2.1	-2.0	-1.7
Condit. Reinf. active minus inactive responses	0.7	0.9	2.1	-0.1	0.4	1.1	1.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.7	0.1	0.2	0.7
Condit. Reinf. active responses	1.0	1.4	2.7	-0.6	0.8	1.3	1.6
Condit. Reinf. inactive responses	0.6	0.8	1.1	-0.9	0.7	1.0	0.9
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.3	0.2	0.3	0.9
Condit. Reinf. lever reinforcers received	0.8	1.2	2.5	-0.5	0.6	1.2	1.6
Conditioned reinforcement - actives	0.1	0.2	0.7	-0.4	0.8	0.1	0.2
Conditioned reinforcement - inactives	0.2	0.3	0.6	0.4	-0.2	-0.8	-0.7
Conditioned locomotion	0.2	0.2	0.4	-0.2	0.6	-0.2	0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.4	0.1	-0.4	-0.5
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.4
Delay disc. indifference point, 0s delay	1.8	2.0	3.1	-1.8	1.1	1.5	1.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.0	-0.6	0.3	-0.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.2	-0.5	-0.8	-0.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.5	0.4	0.8	0.6
Delay disc. indifference point, 4s delay	1.3	1.4	2.7	-1.6	1.2	1.0	0.5
Delay disc. indifference point, 8s delay	0.4	0.5	1.0	-1.0	0.3	0.7	0.5
Indifference point function ln k	0.1	0.1	0.2	0.4	0.0	0.4	0.5
Indifference point function log k	0.1	0.1	0.2	0.4	0.0	0.4	0.5
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	0.6	-0.2	-0.6	-0.8
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.1	-0.6	-0.2	-0.6
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.1	0.2	0.5	-0.5
Patch foraging total patch changes 24 sec	0.4	0.7	1.8	-0.9	0.4	1.4	0.2
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.5	0.4	-0.1	0.1
Patch foraging time to switch 0 sec	0.8	1.6	2.6	-1.4	1.6	0.7	1.2
Patch foraging water rate 0 sec	0.4	0.8	1.4	1.2	-1.0	-0.3	-0.7
Patch foraging water rate 12 sec	0.4	0.8	1.4	0.9	-1.2	-0.3	-0.9
Patch foraging water rate 18 sec	2.5	3.8	5.4	2.3	-1.9	-1.9	-1.6
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.4	-0.6	-0.1	0.2
Patch foraging water rate 6 sec	0.6	0.9	1.3	1.1	-1.1	-0.5	-0.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	-0.6	-0.3	-0.4	-0.2
Distance traveled before self-admin	1.2	1.5	2.0	1.3	-1.0	-1.2	-1.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	0.2	0.0	0.2
Extensor digitorum longus weight	3.0	11.9	13.9	3.7	-3.3	-3.0	-3.7
Bone: elastic displacement	1.4	1.6	2.7	1.5	-1.6	-0.7	-1.1
Bone: elastic work	0.7	1.0	2.0	1.2	-1.4	-0.5	-0.3
Bone: endosteal estimation	0.6	1.2	2.2	0.8	-1.0	-1.5	-1.0
Bone: endosteal perimeter	2.1	4.5	6.4	1.5	-2.0	-2.5	-2.3
Epididymis fat weight	0.6	1.9	3.3	1.8	-1.4	-1.4	-0.5
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.3	-0.5	-0.9	0.0
Delta time in open arm before/after self-admin	0.6	0.6	1.0	-0.6	0.9	1.0	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.6	0.2	0.2	-0.1
Delay discount exponential model param	0.4	0.5	1.0	1.0	-0.4	-0.8	-0.4
Extinction: sum of active levers before priming	0.2	0.2	0.5	0.4	-0.7	-0.2	0.2
Active lever presses in extinction session 6	0.2	0.2	0.5	0.2	-0.2	-0.3	-0.7
Bone: final force	0.1	0.2	0.3	0.1	-0.6	-0.2	0.5
Bone: final moment	0.1	0.2	0.5	0.3	-0.7	-0.2	0.6
Food consumed during 24 hour testing period	0.6	0.8	1.2	-0.5	1.1	0.9	1.0
Glucose	0.8	1.2	2.6	1.6	-1.0	-0.9	-0.7
Heart weight	0.7	1.0	1.7	1.3	-0.9	-0.9	-0.8
Delay discount hyperbolic model param	0.4	0.5	0.9	1.0	-0.5	-0.7	-0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.5	0.3	0.2	-0.2
Intermittent access intake escalation	0.1	0.2	0.4	-0.6	0.4	0.3	-0.2
Intermittent access intake escalation 2	0.9	1.0	2.1	-1.5	1.1	0.9	0.2
Intermitt. access day 1 inactive lever presses	0.2	0.9	2.3	0.5	-0.6	-0.9	-1.5
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	-0.5	0.1	-0.5	-0.3
Intermitt. access escalation Index	0.5	0.7	1.5	-0.8	1.2	0.7	0.1
Intermittent access day 1 total infusions	0.3	0.6	1.4	0.9	-0.0	-1.2	-0.3
Intermittent access day 15 total infusions	0.2	0.2	0.6	0.5	0.1	-0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.6	0.6	0.1	-0.8	-0.6
Intermittent access total infusions	0.6	0.7	1.7	1.0	-0.2	-1.3	-0.6
Intermittent access day 1 locomotion	1.2	1.5	3.6	1.2	-0.5	-1.9	-0.9
Intermittent access day 15 total locomotion	1.1	2.0	5.5	0.9	-0.7	-2.3	-1.0
Intermittent access total locomotion	1.6	1.9	5.3	1.1	-0.4	-2.3	-1.0
Intermittent access standard deviation	0.2	0.3	0.7	0.2	-0.5	-0.8	-0.5
Left kidney weight	2.8	12.8	14.4	3.8	-3.2	-3.6	-3.7
Right kidney weight	3.1	14.1	15.8	4.0	-3.2	-3.8	-3.9
Cocaine induced anxiety	0.4	0.5	1.0	-0.4	0.8	1.0	0.5
Post-drug Anxiety	0.1	0.1	0.2	-0.1	0.5	0.3	0.5
Baseline Anxiety	0.8	1.0	2.1	0.7	-0.9	-1.5	-0.5
Tail length	0.2	0.8	2.3	-0.0	0.9	0.4	1.5
Length with tail	0.0	0.1	0.2	0.4	-0.4	-0.1	0.2
Length without tail	0.3	1.0	1.9	0.6	-1.4	-0.9	-0.9
Times rat made contact with spout	0.7	0.8	1.4	0.8	-1.1	-0.5	-1.2
Lifetime Intake	0.4	0.5	1.0	0.9	-0.1	-1.0	-0.6
Liver weight, left	2.5	4.2	6.6	2.0	-1.3	-2.6	-2.1
Liver weight, right	1.9	3.4	5.5	2.2	-0.9	-2.3	-1.5
Locomotor activity	0.4	0.6	2.1	1.4	-0.1	-0.3	-0.4
Locomotor testing distance	0.1	0.1	0.5	0.7	0.1	-0.1	-0.2
Locomotor testing rearing	0.6	1.2	2.1	1.5	-0.7	-1.0	-1.0
Locomotion in novel chamber	1.6	2.0	3.2	-1.4	1.8	0.9	1.4
Locomotion in novel chamber post-restriction	0.5	0.8	1.8	-0.9	1.3	0.4	0.7
Fecal boli incidents, locomotor time 1	0.7	1.0	1.7	0.5	-0.8	-1.1	-1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.7	-0.3	-0.2	0.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.9	0.7	-0.9	-0.7	-0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	0.0	-0.2	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.4
Rest time, locomotor task time 1	2.2	2.7	4.8	1.4	-2.2	-1.0	-1.7
Distance moved, locomotor task time 1	0.5	0.7	1.7	-0.6	1.3	0.1	0.9
Vertical activity count, locomotor time 1	0.4	0.9	1.8	-0.8	1.3	0.2	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.1	-0.4	-0.1	-0.7
Bouts of movement, locomotor time 2	0.5	0.8	1.1	1.0	-1.1	-0.9	-0.6
Total resting periods, locomotor time 2	0.5	0.9	1.2	1.1	-1.1	-0.8	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.0
Distance moved, locomotor task time 2	0.5	0.5	1.2	-1.1	0.7	0.2	0.6
Vertical activity count, locomotor time 2	0.2	0.3	0.6	-0.8	0.5	0.4	0.5
Light reinforcement 1	0.0	0.1	0.2	-0.2	0.1	-0.5	0.1
Light reinforcement 2	0.1	0.1	0.3	0.0	-0.5	-0.1	0.4
Bone: marrow area	0.7	1.4	2.5	1.0	-1.1	-1.6	-1.1
Bone: maximum diameter	4.6	8.6	10.1	2.6	-2.9	-3.0	-3.2
Bone: maximum force	0.2	0.3	0.6	0.5	-0.8	-0.6	-0.2
Bone: maximum moment	0.3	0.5	0.9	0.7	-0.9	-0.7	-0.2
Mean time between licks in bursts	0.2	0.4	1.1	-0.5	-1.0	0.1	-0.6
Mean num. licks in bursts	1.2	1.8	2.2	1.4	-1.5	-1.0	-1.4
Cd content in liver	0.6	0.7	1.2	-1.0	0.6	1.1	0.6
Co content in liver	0.3	0.4	0.7	0.9	-0.8	-0.4	-0.1
Cu content in liver	0.8	0.9	1.2	-1.1	0.7	0.9	1.0
Fe content in liver	0.1	0.1	0.1	-0.2	0.3	0.3	0.3
K content in liver	1.2	1.2	2.7	0.8	-0.6	-1.6	-1.0
Mg content in liver	0.3	0.3	0.8	0.3	-0.4	-0.9	-0.3
Mn content in liver	4.0	4.4	5.6	2.0	-2.2	-2.4	-1.8
Na content in liver	0.2	0.2	0.9	0.0	0.1	-1.0	-0.0
Rb content in liver	0.1	0.1	0.3	0.3	-0.5	-0.2	-0.0
Se content in liver	0.9	1.1	1.3	-1.1	1.1	1.1	1.0
Sr content in liver	0.1	0.1	0.1	-0.2	0.1	-0.3	0.3
Zn content in liver	0.9	1.0	1.4	-0.6	1.2	1.1	0.9
Bone: minimum diameter	0.1	0.3	0.9	0.1	-0.9	-0.2	-0.3
Time in familiar zone, hab. session 1	6.4	6.2	8.1	-2.3	2.5	2.8	2.2
Time in novel zone, hab. session 1	5.0	5.0	6.6	2.4	-2.2	-2.6	-1.7
Total zone transitions, hab. session 1	4.2	5.9	7.7	2.8	-2.6	-2.1	-2.2
Total locomotion distance, hab. session 1	2.1	2.9	3.5	1.8	-1.8	-1.9	-1.3
Locomotion velocity, hab. session 1	2.5	3.6	4.5	2.0	-2.1	-1.8	-1.6
Time in familiar zone, hab. session 2	0.9	0.9	1.3	-1.0	0.8	1.1	0.9
Time in novel zone, hab. session 2	2.8	2.9	4.1	2.0	-1.6	-1.7	-1.5
Total zone transitions, hab. session 2	4.0	5.1	5.8	2.4	-2.4	-2.0	-2.1
Total locomotion distance, hab. session 2	1.6	2.1	2.7	1.7	-1.4	-1.4	-1.3
Locomotion velocity, hab. session 2	1.7	2.3	2.6	1.6	-1.5	-1.5	-1.4
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.3
Novelty place preference	0.1	0.1	0.2	0.2	-0.4	-0.1	-0.4
Time in novel zone, NPP test	0.3	0.3	0.5	0.6	-0.7	-0.3	-0.6
Total zone transitions, NPP test	9.6	13.8	17.1	4.1	-3.6	-3.4	-3.7
Total locomotion distance, NPP test	5.6	7.7	9.6	3.1	-2.6	-2.9	-2.4
Locomotion velocity, NPP test	4.0	5.6	6.8	2.6	-2.2	-2.6	-2.0
Intraocular pressure	0.7	1.0	1.3	1.1	-1.0	-0.7	-1.0
Delta distance traveled before/after self-admin	1.7	1.8	2.4	-1.4	1.2	1.5	1.3
Delta ambulatory time before/after self-admin	1.2	1.5	1.7	-1.1	1.2	1.1	1.3
Parametrial fat weight	0.1	0.2	0.5	0.7	-0.5	0.1	-0.1
Pavlov. Cond. lever latency	1.0	1.2	2.4	-1.0	1.5	0.8	1.0
Pavlov. Cond. magazine entry latency	1.7	2.2	5.3	1.0	-2.3	-1.3	-1.0
Pavlov. Cond. change in total contacts	0.7	0.7	1.2	0.4	-1.0	-1.1	-0.7
Pavlov. Cond. index score	1.3	1.7	3.7	1.1	-1.9	-0.9	-0.9
Pavlov. Cond. latency score	1.5	1.8	3.9	1.2	-2.0	-1.0	-1.1
Pavlov. Cond. lever contacts	1.3	1.6	3.0	1.1	-1.7	-1.0	-1.0
Pavlov. Cond. magazine entry number	0.6	0.7	2.3	-0.5	1.5	0.5	0.4
Pavlov. Cond. intertrial magazine entries	3.4	4.1	5.1	-1.8	2.3	1.8	2.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.2	0.9	-1.8	-0.9	-0.9
Pavlov. Cond. response bias	0.6	0.8	2.2	0.5	-1.5	-0.7	-0.5
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.5	0.6	0.1	-0.2
Pavlov. Cond. magazine entry latency	1.3	1.5	3.0	1.1	-1.7	-1.0	-1.0
Pavlov. Cond. change in total contacts	0.8	1.3	2.3	1.4	-1.5	-0.8	-0.5
Pavlov. Cond. index score	0.3	0.4	1.1	0.6	-1.0	-0.4	-0.2
Pavlov. Cond. latency score	0.4	0.5	1.2	0.7	-1.1	-0.5	-0.3
Pavlov. Cond. lever contacts	0.3	0.4	1.0	0.6	-1.0	-0.5	-0.1
Pavlov. Cond. magazine entry number	0.6	0.8	1.9	-0.5	1.4	0.7	0.6
Pavlov. Cond. intertrial magazine entries	4.6	6.9	7.8	-2.5	2.8	2.5	2.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	0.6	-1.1	-0.5	-0.2
Pavlov. Cond. response bias	0.5	0.7	1.9	0.6	-1.4	-0.8	-0.3
Time in closed arm before self-admin	0.2	0.3	0.3	0.6	0.5	0.5	-0.5
Time in closed arm after self-admin	0.6	0.7	1.0	0.9	-0.4	-1.0	-0.8
Time in open arm before self-admin	0.6	0.6	2.0	-0.6	-0.3	0.4	1.4
Time in open arm after self-admin	1.6	1.8	2.9	-1.7	1.0	1.5	1.0
Bone: periosteal estimation	1.6	3.5	4.1	1.7	-2.0	-2.0	-1.7
Bone: periosteal perimeter	2.8	4.8	5.7	2.0	-2.4	-2.2	-2.2
Bone: post-yield work	0.3	0.4	1.4	-1.2	0.1	0.1	-0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.2	-0.4	1.1	0.8	0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.5	-0.3	-0.1	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.4	-0.1	0.1	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.3	0.4	0.5	0.4
Incentive Sensitization - Responses	0.4	0.6	1.1	0.7	-1.0	-0.0	0.8
Incentive Sensitization - Breakpoint	0.4	0.5	1.1	0.7	-1.0	-0.1	0.7
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.8	0.9	-0.9	-1.3	-0.5
Progressive ratio	1.6	2.5	3.8	1.2	-2.0	-1.6	-1.5
Food seeking constrained by brief footshock	0.5	0.6	1.2	0.6	-0.9	-0.6	-1.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.4	0.5	0.5	0.3
Retroperitoneal fat weight	0.8	3.3	4.9	2.2	-2.1	-1.7	-0.8
Reaction time number correct	0.1	0.3	0.7	0.5	0.4	-0.8	0.0
Reaction time mean minus median	0.6	1.4	3.5	0.9	-0.3	-1.1	-1.9
Reaction time mean minus median AUC	0.8	2.1	4.1	1.6	-0.7	-1.2	-2.0
Reaction time num false alarms	1.0	1.4	2.4	-1.0	1.3	1.6	0.7
Reaction time num false alarms AUC	1.1	1.7	2.4	-1.3	1.6	1.5	0.6
Reaction time trials correct on left	0.1	0.3	0.7	0.5	0.4	-0.8	0.0
Reaction time trials on left	0.1	0.3	0.6	0.5	0.4	-0.8	0.0
Reaction time mean	0.4	0.7	1.7	-0.2	-0.5	-0.9	-1.3
Reaction time mean AUC	0.2	0.3	0.8	-0.5	-0.2	-0.5	-0.9
Median of all reaction times	0.2	0.4	0.6	-0.8	-0.3	-0.6	-0.6
Reaction time omissions	0.2	0.4	0.9	-0.5	0.5	0.9	-0.0
Reaction time false alarm rate	1.1	1.5	3.1	-1.3	1.1	1.8	0.5
Reaction time premature initiation rate	0.2	0.3	0.8	-0.9	0.3	0.3	0.0
Reaction time premature initiations	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.1
Std. dev. reaction times	0.4	0.8	2.4	0.2	-0.2	-0.7	-1.5
Reaction time trials completed	0.1	0.3	0.6	0.5	0.4	-0.8	0.0
Reaction time trials AUC	0.1	0.2	0.5	0.3	0.5	-0.7	0.1
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.3	0.4	0.5	0.7
Run reversals in cocaine runway, males	1.5	1.5	1.9	0.8	-1.4	-1.2	-1.3
Latency to leave start box in cocaine runway	2.2	2.5	3.2	-1.5	1.3	1.8	1.8
Latency to leave start box in cocaine runway, F	2.0	2.2	3.5	-1.2	1.4	1.9	1.4
Latency to leave start box in cocaine runway, M	0.7	0.7	1.3	-0.9	0.5	0.6	1.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.0
Total sessions with >9 infusions	0.2	0.2	0.4	0.2	0.6	0.6	0.0
Short access day 1 total inactive lever presses	0.2	0.3	0.6	0.2	0.3	-0.6	-0.8
Short access day 10 total inactive lever presses	0.4	0.9	1.7	0.5	-1.0	-0.7	-1.3
Short access day 1 total infusions	0.3	0.4	1.2	-0.4	1.1	0.6	0.0
Short access day 10 total infusions	0.6	0.7	1.3	1.2	-0.3	-1.0	-0.6
Short access total infusions	0.1	0.1	0.2	0.4	0.5	-0.0	-0.2
Short access day 1 locomotion	0.1	0.2	0.5	0.1	0.7	0.3	-0.3
Short access day 10 total locomotion	0.9	1.7	2.7	0.9	-1.1	-1.5	-1.7
Short access total locomotion	0.8	1.0	1.9	1.2	-0.5	-0.7	-1.4
One hour access (0.3 mA shock)	0.2	0.3	0.7	-0.3	0.9	0.3	0.4
Compulsive drug intake	5.0	5.9	7.0	-2.2	2.3	2.5	2.7
One hour access (shock baseline)	0.1	0.2	0.3	0.4	-0.3	-0.5	-0.3
Social response proportion	0.2	0.2	0.4	-0.6	0.4	0.6	-0.1
Social responses	0.0	0.1	0.2	-0.1	-0.2	-0.4	-0.1
Social time	0.3	0.4	0.9	-0.5	0.3	0.5	-1.0
Soleus weight	1.1	3.2	5.4	2.3	-1.8	-1.1	-1.7
Bone: stiffness	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1
Tibialis anterior weight	1.0	3.4	7.0	2.6	-1.3	-1.2	-1.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.1	-0.1	-0.3	-0.6
Time to tail flick, vehicle, after self-admin	0.8	1.0	1.9	1.4	-1.2	-0.6	-0.7
Time to tail flick, test, before self-admin	0.2	0.2	0.7	-0.2	0.2	-0.8	-0.0
Time to tail flick, test, after self-admin	0.2	0.3	0.6	0.2	-0.8	-0.6	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	1.0	-0.6	-0.1	-0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.1	-0.4	0.3	0.0
Tibia length	0.1	0.4	0.9	1.0	-0.4	-0.5	-0.3
Ambulatory time before self-admin	1.2	1.8	2.5	1.3	-1.1	-1.3	-1.6
Ambulatory time after self-admin	0.0	0.0	0.1	-0.0	0.4	0.0	0.0
Bone: tissue strength	0.1	0.1	0.2	0.4	-0.1	-0.5	-0.0
Total heroin consumption	0.4	0.4	0.9	0.7	-0.9	-0.5	0.3
Bone: trabecular number	2.0	3.3	6.3	-2.5	1.2	1.6	1.6
Bone: trabecular spacing	0.2	0.3	0.5	0.7	-0.1	-0.6	-0.6
Bone: trabecular thickness	0.2	0.3	0.8	0.4	0.3	0.3	0.9
Bone: trabecular tissue density	1.7	2.6	4.1	2.0	-1.4	-1.5	-1.4
Water consumed over 24 hours	0.0	0.0	0.1	0.1	0.1	0.2	0.4
Number of responses in last shaping day	0.7	0.8	2.2	0.4	-0.2	-0.9	-1.5