LOC120093830

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression LOC120093830 0.02 0.02 3.2e-03 0.01 0.01 0.01 0.01 7.2e-03 7.2e-03 3.7e-02 1.1e-02
2 Liver gene expression LOC120093830 0.05 0.05 2.4e-05 0.04 0.04 0.04 0.03 4.9e-05 6.7e-05 8.0e-05 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density9.016.617.44.2-4.0
Area under the delay curve0.50.80.90.9-0.9
BMI with tail7.124.925.84.9-5.1
BMI without tail1.15.96.62.3-2.6
Body weight7.231.332.45.5-5.7
Weight adjusted by age1.44.14.51.9-2.1
Bone surface10.520.622.04.7-4.4
Bone volume7.715.316.64.1-3.7
Breakpoint value in progressive ratio session0.91.71.81.3-1.3
Number of licking bursts0.10.20.5-0.70.0
Context. condit. distance diff. score0.60.71.10.6-1.0
Locomotion velocity, session 11.01.21.5-0.91.2
Locomotion distance, session 13.34.25.0-1.82.2
Locomotion velocity, session 20.50.61.0-0.51.0
Locomotion distance, session 22.94.05.0-1.82.2
Locomotion velocity, session 34.45.05.3-2.22.3
Locomotion distance, session 35.26.06.2-2.42.5
Stereotopy head waving bouts, day 30.91.01.41.2-0.8
Stereotopy head waving duration, day 30.40.50.80.9-0.3
Locomotion velocity, session 70.10.20.3-0.50.3
Locomotion distance, session 71.21.52.1-1.50.9
Stereotopy head waving bouts, day 71.21.41.51.2-1.2
Stereotopy head waving duration, day 71.01.21.41.2-1.0
Locomotion velocity, session 80.00.00.00.1-0.0
Locomotion distance, session 81.01.41.6-1.31.1
Degree of sensitization distance0.80.81.20.7-1.1
Degree of sensitization stereotypy0.20.20.30.4-0.5
Conditioned locomotion0.00.00.00.10.1
Cocaine response after cond. corrected0.00.00.1-0.10.2
Cocaine response after cond. not corrected0.50.80.8-0.80.9
Cocaine response before conditioning3.44.14.5-2.12.0
Saline control response0.00.00.00.2-0.1
Bone: connectivity density6.410.311.03.3-3.1
Bone: cortical apparent density0.10.20.2-0.50.5
Bone: cortical area10.917.717.94.2-4.2
Bone: cortical porosity1.01.11.6-0.91.2
Bone: cortical porosity1.21.31.6-1.01.3
Bone: cortical thickness4.57.57.92.7-2.8
Bone: cortical thickness0.20.30.50.3-0.7
Bone: cortical tissue density0.20.30.3-0.60.6
Condit. Reinf. active minus inactive responses0.20.20.5-0.20.7
Condit. Reinf. active-inactive response ratio0.10.10.30.5-0.0
Condit. Reinf. active responses0.91.11.5-0.81.2
Condit. Reinf. inactive responses2.63.33.6-1.91.8
Incentive salience index mean0.00.00.00.10.1
Condit. Reinf. lever presses0.10.10.10.4-0.2
Condit. Reinf. active minus inactive responses0.00.00.0-0.10.1
Condit. Reinf. active-inactive response ratio0.30.40.4-0.60.7
Condit. Reinf. active responses0.10.20.3-0.50.3
Condit. Reinf. inactive responses0.30.50.7-0.80.5
Condit. Reinf. lever presses0.10.10.10.1-0.4
Condit. Reinf. lever reinforcers received0.40.50.7-0.80.6
Conditioned reinforcement - actives0.41.51.9-1.41.1
Conditioned reinforcement - inactives2.15.76.1-2.52.3
Conditioned locomotion0.10.20.2-0.50.3
Patch foraging indifference point 0 sec1.23.33.8-2.01.7
Patch foraging indifference point AUC0.40.91.1-1.10.8
Delay disc. indifference point, 0s delay1.01.11.31.2-0.9
Delay disc. indifference point, 16s delay0.71.01.20.9-1.1
Delay disc. indifference point, 2s delay1.11.21.41.2-1.0
Delay disc. indifference point, 24s delay0.81.41.61.1-1.2
Delay disc. indifference point, 4s delay0.30.30.30.6-0.5
Delay disc. indifference point, 8s delay1.42.32.51.5-1.6
Indifference point function ln k1.65.05.32.3-2.2
Indifference point function log k1.65.05.32.3-2.2
Patch foraging total patch changes 0 sec1.13.23.8-1.91.6
Patch foraging total patch changes 12 sec2.12.83.3-1.81.5
Patch foraging total patch changes 18 sec2.15.05.7-2.42.1
Patch foraging total patch changes 24 sec0.72.53.0-1.71.4
Patch foraging total patch changes 6 sec2.13.64.1-2.01.7
Patch foraging time to switch 0 sec1.03.73.7-1.91.9
Patch foraging water rate 0 sec1.45.45.42.3-2.3
Patch foraging water rate 12 sec1.35.35.42.3-2.3
Patch foraging water rate 18 sec0.30.60.90.6-0.9
Patch foraging water rate 24 sec3.04.34.52.1-2.0
Patch foraging water rate 6 sec4.05.96.22.5-2.4
Seeking ratio, delayed vs. immediate footshock0.00.10.10.4-0.1
Distance traveled before self-admin0.40.90.9-1.00.9
Distance traveled after self-admin0.30.40.6-0.50.8
Extensor digitorum longus weight4.517.920.33.9-4.5
Bone: elastic displacement4.55.86.8-2.22.6
Bone: elastic work0.10.10.20.20.4
Bone: endosteal estimation7.217.618.34.3-4.1
Bone: endosteal perimeter6.816.717.93.9-4.2
Epididymis fat weight0.52.63.11.8-1.4
Delta time in closed arm before/after self-admin0.00.00.0-0.10.1
Delta time in open arm before/after self-admin1.11.31.4-1.11.2
Diff in mean of infusions in LGA sessions0.61.11.31.1-0.9
Delay discount exponential model param0.60.80.8-0.80.9
Extinction: sum of active levers before priming1.11.72.01.4-1.2
Active lever presses in extinction session 61.11.11.31.1-0.9
Bone: final force10.316.718.74.3-3.9
Bone: final moment11.017.820.34.5-3.9
Food consumed during 24 hour testing period1.02.02.21.5-1.3
Glucose0.30.50.90.4-0.9
Heart weight0.10.20.30.3-0.6
Delay discount hyperbolic model param0.50.70.7-0.80.8
Intermittent access intake day 1-15 change0.00.10.1-0.4-0.2
Intermittent access intake escalation0.00.10.2-0.1-0.4
Intermittent access intake escalation 20.10.10.2-0.5-0.0
Intermitt. access day 1 inactive lever presses0.11.11.2-1.01.1
Intermitt. access day 15 inactive lever presses0.21.31.6-1.21.1
Intermitt. access escalation Index0.30.81.10.8-1.0
Intermittent access day 1 total infusions0.41.31.4-1.21.1
Intermittent access day 15 total infusions0.30.81.4-1.20.5
Intermittent access terminal intake (last 3 days)0.81.31.9-1.40.9
Intermittent access total infusions1.51.82.5-1.61.0
Intermittent access day 1 locomotion0.00.10.1-0.30.1
Intermittent access day 15 total locomotion0.00.20.3-0.5-0.1
Intermittent access total locomotion0.91.11.7-1.30.7
Intermittent access standard deviation0.10.40.6-0.80.4
Left kidney weight0.43.33.81.9-1.6
Right kidney weight2.718.819.54.4-4.3
Cocaine induced anxiety1.84.85.72.0-2.4
Post-drug Anxiety3.64.14.51.9-2.1
Baseline Anxiety0.00.00.00.10.1
Tail length0.00.00.00.1-0.2
Length with tail1.66.97.02.7-2.6
Length without tail3.417.718.54.3-4.1
Times rat made contact with spout0.10.10.1-0.30.3
Lifetime Intake1.92.33.3-1.81.2
Liver weight, left9.917.017.54.1-4.2
Liver weight, right2.64.54.82.2-2.0
Locomotor activity1.21.92.1-1.51.3
Locomotor testing distance1.94.75.4-2.32.0
Locomotor testing rearing0.93.34.3-2.11.5
Locomotion in novel chamber1.21.61.71.3-1.2
Locomotion in novel chamber post-restriction0.00.10.1-0.20.4
Fecal boli incidents, locomotor time 11.12.83.2-1.61.8
Change in fecal boli incidents, locomotor task0.60.60.90.9-0.6
Time >=10cm from walls, locomotor time 10.00.10.10.2-0.3
Bouts of movement, locomotor time 10.10.10.20.00.4
Total resting periods, locomotor time 10.50.60.9-0.50.9
Rest time, locomotor task time 10.30.50.7-0.60.8
Distance moved, locomotor task time 10.00.10.20.2-0.5
Vertical activity count, locomotor time 10.31.92.31.2-1.5
Time >=10cm from walls, locomotor time 20.41.11.3-0.91.2
Bouts of movement, locomotor time 21.03.33.41.8-1.8
Total resting periods, locomotor time 20.93.83.81.9-2.0
Rest time, locomotor task time 20.00.00.10.0-0.2
Distance moved, locomotor task time 20.10.10.2-0.20.4
Vertical activity count, locomotor time 20.00.10.10.2-0.3
Light reinforcement 11.04.55.7-2.41.8
Light reinforcement 20.51.11.3-1.11.0
Bone: marrow area7.017.217.84.2-4.1
Bone: maximum diameter4.28.59.42.7-3.1
Bone: maximum force14.027.629.95.5-5.0
Bone: maximum moment15.028.431.65.6-5.0
Mean time between licks in bursts0.10.40.6-0.40.8
Mean num. licks in bursts0.10.20.40.10.6
Cd content in liver0.80.90.9-0.91.0
Co content in liver0.10.10.3-0.50.0
Cu content in liver1.11.31.41.2-1.1
Fe content in liver1.72.12.3-1.51.3
K content in liver0.00.00.10.1-0.3
Mg content in liver0.20.20.3-0.30.5
Mn content in liver0.10.10.20.00.4
Na content in liver0.00.00.1-0.2-0.2
Rb content in liver0.00.00.0-0.1-0.2
Se content in liver1.41.62.0-1.41.2
Sr content in liver1.91.72.01.2-1.4
Zn content in liver0.80.91.0-1.00.9
Bone: minimum diameter9.518.318.54.3-4.3
Time in familiar zone, hab. session 10.40.40.6-0.40.8
Time in novel zone, hab. session 10.40.40.60.5-0.8
Total zone transitions, hab. session 10.40.50.6-0.70.7
Total locomotion distance, hab. session 10.00.00.10.10.3
Locomotion velocity, hab. session 10.00.00.00.20.1
Time in familiar zone, hab. session 20.20.20.40.6-0.2
Time in novel zone, hab. session 20.10.10.2-0.50.1
Total zone transitions, hab. session 20.40.50.6-0.60.8
Total locomotion distance, hab. session 20.20.30.6-0.30.8
Locomotion velocity, hab. session 20.10.20.3-0.10.6
Novel to familiar place preference ratio2.02.73.41.4-1.8
Novelty place preference1.62.12.71.2-1.6
Time in novel zone, NPP test1.51.82.51.1-1.6
Total zone transitions, NPP test1.62.32.8-1.41.7
Total locomotion distance, NPP test2.02.83.4-1.51.9
Locomotion velocity, NPP test1.21.72.2-1.11.5
Intraocular pressure6.710.911.5-3.23.4
Delta distance traveled before/after self-admin0.00.00.00.00.2
Delta ambulatory time before/after self-admin0.00.00.0-0.20.2
Parametrial fat weight0.92.12.5-1.61.3
Pavlov. Cond. lever latency0.10.10.20.5-0.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.20.1
Pavlov. Cond. change in total contacts0.10.10.30.1-0.5
Pavlov. Cond. index score0.10.10.20.0-0.5
Pavlov. Cond. latency score0.10.10.2-0.1-0.4
Pavlov. Cond. lever contacts0.30.40.7-0.80.3
Pavlov. Cond. magazine entry number0.00.00.00.10.2
Pavlov. Cond. intertrial magazine entries0.70.81.3-0.61.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.3-0.7
Pavlov. Cond. response bias0.10.10.2-0.40.2
Pavlov. Cond. lever latency0.10.10.10.3-0.2
Pavlov. Cond. magazine entry latency1.01.41.51.2-1.2
Pavlov. Cond. change in total contacts1.22.93.41.5-1.8
Pavlov. Cond. index score0.71.11.30.9-1.2
Pavlov. Cond. latency score0.60.91.10.9-1.0
Pavlov. Cond. lever contacts0.00.00.0-0.2-0.0
Pavlov. Cond. magazine entry number2.63.43.7-1.81.9
Pavlov. Cond. intertrial magazine entries4.49.710.3-3.03.2
Pavlov. Cond. lever-magazine prob. diff.1.01.51.81.1-1.3
Pavlov. Cond. response bias0.10.10.20.3-0.5
Time in closed arm before self-admin2.03.53.91.8-2.0
Time in closed arm after self-admin0.20.20.20.4-0.5
Time in open arm before self-admin0.00.00.0-0.2-0.1
Time in open arm after self-admin0.10.10.2-0.20.4
Bone: periosteal estimation11.928.228.45.3-5.3
Bone: periosteal perimeter9.919.619.84.4-4.4
Bone: post-yield work7.813.513.83.7-3.6
Progressive ratio test 1 active lever presses3.45.97.6-2.82.1
Progressive ratio test 1 breakpoint3.15.47.0-2.61.9
Progressive ratio test 1 inactive lever presses1.02.63.2-1.81.4
Progressive ratio test 2 active lever presses1.31.92.7-1.61.0
Progressive ratio test 2 breakpoint1.31.72.5-1.60.9
Progressive ratio test 2 inactive lever presses0.51.62.2-1.50.9
Incentive Sensitization - Responses0.10.30.40.4-0.6
Incentive Sensitization - Breakpoint0.10.20.30.2-0.5
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.1
Progressive ratio0.10.20.3-0.60.3
Food seeking constrained by brief footshock0.60.81.1-1.00.7
Seeking ratio, punishment vs. effort0.00.00.0-0.10.2
Retroperitoneal fat weight0.41.72.1-1.11.5
Reaction time number correct0.41.42.21.5-0.8
Reaction time mean minus median1.710.811.6-3.43.2
Reaction time mean minus median AUC1.17.48.0-2.82.6
Reaction time num false alarms1.32.22.3-1.41.5
Reaction time num false alarms AUC1.43.13.2-1.81.8
Reaction time trials correct on left0.41.42.21.5-0.8
Reaction time trials on left0.31.11.71.3-0.6
Reaction time mean0.40.91.0-1.00.9
Reaction time mean AUC0.20.50.6-0.80.6
Median of all reaction times0.00.00.00.1-0.2
Reaction time omissions9.515.516.3-3.84.0
Reaction time false alarm rate2.33.13.6-1.91.6
Reaction time premature initiation rate4.36.78.3-2.92.3
Reaction time premature initiations1.13.43.8-2.01.7
Std. dev. reaction times2.68.79.2-3.02.9
Reaction time trials completed0.31.11.71.3-0.6
Reaction time trials AUC0.51.82.81.7-0.9
Run reversals in cocaine runway, females0.00.00.10.1-0.3
Run reversals in cocaine runway, males1.21.31.3-1.11.1
Latency to leave start box in cocaine runway0.00.00.0-0.20.1
Latency to leave start box in cocaine runway, F0.81.01.2-1.10.9
Latency to leave start box in cocaine runway, M1.71.61.71.3-1.2
Std. dev. time between licks in bursts0.51.01.3-1.10.8
Total sessions with >9 infusions1.82.23.2-1.81.2
Short access day 1 total inactive lever presses1.02.02.6-1.61.1
Short access day 10 total inactive lever presses0.00.20.2-0.30.4
Short access day 1 total infusions0.40.71.0-1.00.7
Short access day 10 total infusions0.91.62.3-1.50.9
Short access total infusions1.82.53.7-1.91.2
Short access day 1 locomotion0.10.10.3-0.50.1
Short access day 10 total locomotion0.10.20.3-0.60.3
Short access total locomotion0.50.81.2-1.10.6
One hour access (0.3 mA shock)0.10.10.2-0.5-0.1
Compulsive drug intake0.10.10.3-0.00.5
One hour access (shock baseline)0.10.20.4-0.1-0.7
Social response proportion0.10.10.2-0.40.2
Social responses6.58.610.2-3.22.6
Social time0.00.00.00.10.2
Soleus weight0.61.81.81.3-1.4
Bone: stiffness16.830.531.15.6-5.5
Tibialis anterior weight1.44.97.11.6-2.7
Time to tail flick, vehicle, before self-admin1.72.02.5-1.31.6
Time to tail flick, vehicle, after self-admin0.00.10.10.3-0.3
Time to tail flick, test, before self-admin0.50.61.0-0.51.0
Time to tail flick, test, after self-admin0.60.70.80.9-0.7
Delta time to tail flick, vehicle, before/after SA0.50.60.70.7-0.8
Delta time to tail flick, test, before/after SA0.30.40.60.5-0.8
Tibia length7.922.122.74.6-4.8
Ambulatory time before self-admin0.82.62.6-1.61.6
Ambulatory time after self-admin0.91.51.5-1.21.2
Bone: tissue strength0.90.91.31.1-0.8
Total heroin consumption1.11.21.41.0-1.2
Bone: trabecular number5.19.610.93.3-2.9
Bone: trabecular spacing2.03.03.4-1.91.6
Bone: trabecular thickness0.00.10.1-0.30.2
Bone: trabecular tissue density0.00.00.0-0.10.1
Water consumed over 24 hours0.00.10.10.3-0.2
Number of responses in last shaping day0.10.10.2-0.4-0.4