Hub : Genes

LOC120093824

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability LOC120093824 0.05 0.04 7.7e-04 0.02 0.03 0.02 0.02 1.6e-04 5.9e-05 4.8e-04 2.1e-04
2 PL gene expression LOC120093824 0.02 0.02 5.0e-03 0.03 0.02 0.01 0.02 2.7e-04 4.2e-03 9.0e-03 1.4e-03
3 Adipose gene expression LOC120093824 0.21 0.1 0.0e+00 0.26 0.27 0.27 0.27 4.5e-29 5.0e-30 1.8e-29 2.1e-29
4 Liver gene expression LOC120093824 0.31 0.11 0.0e+00 0.18 0.19 0.19 0.19 1.2e-19 6.9e-21 4.9e-21 1.6e-20
5 PL mRNA stability LOC120093824 0.03 0.03 9.6e-03 0.01 0.02 0.02 0.02 8.5e-03 6.0e-03 3.5e-03 4.7e-03
6 PL isoform ratio XR_005487568.2 0.04 0.03 7.6e-03 0.01 0.02 0 0.02 1.2e-02 3.9e-03 1.3e-01 5.5e-03
7 Liver mRNA stability LOC120093824 0.07 0.04 1.7e-07 0.02 0.05 0.04 0.04 2.0e-03 5.6e-06 4.4e-05 3.3e-05
8 Brain mRNA stability LOC120093824 0.04 0.03 3.9e-03 0.02 0.02 0.01 0.01 9.8e-03 5.5e-03 3.1e-02 3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.12.3-0.41.41.5-1.2-0.10.4-1.21.0
Area under the delay curve1.61.93.31.11.11.0-0.91.81.5-1.61.6
BMI with tail2.48.217.72.9-4.2-3.93.9-0.01.12.1-1.8
BMI without tail1.34.08.00.8-2.8-2.72.3-1.3-0.42.2-2.1
Body weight1.04.29.31.9-3.1-2.72.8-0.20.71.6-1.4
Weight adjusted by age1.32.04.32.1-1.7-1.81.90.41.30.6-0.4
Bone surface1.12.13.50.71.41.6-1.11.21.5-1.91.8
Bone volume1.12.03.10.31.61.7-1.40.81.1-1.81.7
Breakpoint value in progressive ratio session0.20.31.01.0-0.4-0.20.20.40.8-0.30.4
Number of licking bursts0.00.10.2-0.50.10.1-0.00.1-0.40.1-0.2
Context. condit. distance diff. score1.41.73.5-0.0-1.9-1.61.1-1.1-0.71.6-1.5
Locomotion velocity, session 10.10.10.20.5-0.2-0.30.40.20.30.1-0.1
Locomotion distance, session 11.72.13.8-0.22.01.9-1.71.10.6-1.71.6
Locomotion velocity, session 20.50.61.80.8-1.0-0.81.3-0.10.40.4-0.4
Locomotion distance, session 20.71.02.0-0.21.41.3-0.91.00.4-1.11.1
Locomotion velocity, session 31.92.24.0-2.0-0.3-0.50.8-1.8-2.01.5-1.7
Locomotion distance, session 30.10.10.4-0.60.20.1-0.3-0.5-0.60.2-0.3
Stereotopy head waving bouts, day 31.41.62.70.11.61.6-1.31.00.8-1.51.5
Stereotopy head waving duration, day 30.30.40.8-0.50.90.9-0.8-0.1-0.1-0.60.5
Locomotion velocity, session 71.21.32.4-0.6-0.9-1.30.2-1.1-1.31.5-1.5
Locomotion distance, session 70.20.30.6-0.2-0.4-0.7-0.1-0.3-0.60.8-0.7
Stereotopy head waving bouts, day 70.50.61.7-0.70.91.3-0.6-0.60.1-0.80.6
Stereotopy head waving duration, day 70.60.71.9-1.41.01.1-0.6-1.0-0.7-0.30.1
Locomotion velocity, session 81.31.52.4-0.1-1.3-1.31.5-1.6-0.61.3-1.4
Locomotion distance, session 80.30.41.10.7-1.0-0.81.00.10.50.4-0.4
Degree of sensitization distance0.80.81.81.3-1.0-1.21.00.40.80.4-0.3
Degree of sensitization stereotypy0.40.41.4-1.10.10.40.0-1.2-0.70.2-0.4
Conditioned locomotion0.40.50.8-0.1-0.9-0.80.8-0.2-0.40.8-0.8
Cocaine response after cond. corrected0.80.91.60.3-1.2-1.21.2-0.8-0.21.0-1.0
Cocaine response after cond. not corrected1.92.34.00.3-2.0-1.92.0-1.1-0.41.6-1.6
Cocaine response before conditioning0.70.82.20.4-1.5-1.21.2-0.3-0.00.8-0.8
Saline control response0.91.23.21.8-0.8-0.61.21.11.6-0.30.4
Bone: connectivity density0.40.61.5-0.71.01.2-0.6-0.50.0-0.80.6
Bone: cortical apparent density1.31.84.1-1.21.81.8-2.00.6-0.5-1.00.9
Bone: cortical area1.31.95.42.2-0.9-0.70.22.31.7-0.50.8
Bone: cortical porosity1.01.12.81.7-0.1-0.30.61.41.6-0.60.7
Bone: cortical porosity1.31.44.12.0-0.5-0.61.01.31.9-0.50.6
Bone: cortical thickness0.40.62.60.9-0.1-0.2-0.61.60.7-0.30.5
Bone: cortical thickness0.50.61.50.2-0.8-1.2-0.3-0.7-0.61.0-0.8
Bone: cortical tissue density1.21.63.6-1.21.71.7-1.90.5-0.5-0.90.8
Condit. Reinf. active minus inactive responses1.01.22.81.7-1.3-1.31.10.81.10.3-0.2
Condit. Reinf. active-inactive response ratio0.10.10.20.4-0.5-0.40.40.20.30.2-0.2
Condit. Reinf. active responses1.41.73.21.8-1.8-1.71.50.71.00.6-0.5
Condit. Reinf. inactive responses0.91.12.11.3-1.4-1.41.30.40.70.5-0.4
Incentive salience index mean1.72.15.22.3-1.8-1.61.41.21.50.3-0.1
Condit. Reinf. lever presses1.31.94.22.1-1.6-1.51.51.31.40.3-0.2
Condit. Reinf. active minus inactive responses1.31.73.71.90.50.4-0.81.21.8-1.41.6
Condit. Reinf. active-inactive response ratio0.30.40.90.90.30.1-0.60.60.7-0.60.7
Condit. Reinf. active responses1.41.96.22.5-0.3-0.3-0.01.32.1-1.11.3
Condit. Reinf. inactive responses0.60.82.41.5-0.9-0.70.60.81.1-0.20.4
Condit. Reinf. lever presses1.21.65.22.3-1.2-1.11.01.11.6-0.20.4
Condit. Reinf. lever reinforcers received1.52.16.12.5-0.2-0.1-0.21.52.1-1.21.5
Conditioned reinforcement - actives0.30.61.91.4-0.7-0.70.80.21.0-0.00.1
Conditioned reinforcement - inactives0.10.20.60.1-0.5-0.50.4-0.8-0.10.4-0.4
Conditioned locomotion1.31.73.31.2-1.8-1.81.7-0.40.51.0-0.9
Patch foraging indifference point 0 sec0.20.40.70.8-0.8-0.80.9-0.00.40.3-0.2
Patch foraging indifference point AUC2.23.16.02.00.91.1-0.41.92.4-2.12.2
Delay disc. indifference point, 0s delay2.42.66.52.5-0.6-0.40.82.42.3-1.01.1
Delay disc. indifference point, 16s delay0.60.71.10.90.40.5-0.41.01.1-0.90.9
Delay disc. indifference point, 2s delay6.47.111.22.41.92.0-1.53.33.1-3.13.2
Delay disc. indifference point, 24s delay0.30.30.90.5-0.6-0.80.90.10.10.5-0.4
Delay disc. indifference point, 4s delay1.92.04.70.91.11.2-1.02.21.4-1.61.6
Delay disc. indifference point, 8s delay0.81.01.8-0.01.31.1-1.31.00.4-1.01.0
Indifference point function ln k1.32.34.20.0-1.8-2.01.5-1.0-0.91.9-1.8
Indifference point function log k1.32.34.20.0-1.8-2.01.5-1.0-0.91.9-1.8
Patch foraging total patch changes 0 sec0.10.20.30.5-0.5-0.50.5-0.10.20.2-0.2
Patch foraging total patch changes 12 sec1.11.43.31.8-0.10.10.31.51.8-1.11.2
Patch foraging total patch changes 18 sec1.42.24.11.11.21.4-1.30.81.6-2.02.0
Patch foraging total patch changes 24 sec0.30.61.10.90.30.5-0.60.11.0-1.01.0
Patch foraging total patch changes 6 sec0.71.12.61.30.20.50.31.11.6-1.11.1
Patch foraging time to switch 0 sec0.10.20.5-0.70.40.5-0.7-0.1-0.5-0.10.0
Patch foraging water rate 0 sec0.30.71.30.2-1.1-1.10.9-0.7-0.41.0-0.9
Patch foraging water rate 12 sec0.71.53.30.8-1.7-1.81.4-0.6-0.11.3-1.2
Patch foraging water rate 18 sec2.64.05.6-0.2-2.4-2.41.9-2.2-1.22.3-2.3
Patch foraging water rate 24 sec1.11.63.1-0.6-1.1-1.21.1-1.8-1.01.5-1.5
Patch foraging water rate 6 sec0.40.61.1-0.0-1.1-1.00.8-0.6-0.50.9-0.9
Seeking ratio, delayed vs. immediate footshock0.30.40.7-0.80.70.8-0.8-0.4-0.4-0.30.2
Distance traveled before self-admin1.01.32.5-0.41.21.3-1.61.60.1-1.00.9
Distance traveled after self-admin0.20.20.6-0.8-0.00.1-0.3-0.0-0.70.3-0.4
Extensor digitorum longus weight0.31.12.00.3-1.4-1.41.1-0.8-0.31.2-1.1
Bone: elastic displacement0.30.31.0-0.41.00.9-0.4-0.20.2-0.60.4
Bone: elastic work0.10.20.40.6-0.3-0.30.60.00.6-0.00.0
Bone: endosteal estimation0.40.82.41.5-0.8-0.40.70.71.3-0.40.5
Bone: endosteal perimeter2.55.314.63.8-0.9-0.50.72.93.5-1.61.8
Epididymis fat weight1.34.39.63.1-2.6-2.52.51.31.90.7-0.4
Delta time in closed arm before/after self-admin0.20.10.30.50.20.1-0.20.40.6-0.30.4
Delta time in open arm before/after self-admin0.00.00.1-0.2-0.00.10.00.3-0.10.0-0.1
Diff in mean of infusions in LGA sessions1.11.34.22.1-1.0-1.01.10.61.6-0.20.3
Delay discount exponential model param1.21.32.2-0.8-1.0-1.00.8-1.5-1.21.3-1.4
Extinction: sum of active levers before priming0.80.81.40.90.50.6-0.81.21.1-1.01.0
Active lever presses in extinction session 61.21.22.60.8-1.6-1.51.2-0.80.21.0-1.0
Bone: final force0.40.72.80.90.00.1-0.51.70.7-0.60.7
Bone: final moment0.30.62.20.60.20.3-0.61.50.6-0.60.7
Food consumed during 24 hour testing period1.21.73.30.7-1.8-1.81.7-0.5-0.11.4-1.2
Glucose0.40.61.10.70.90.6-0.50.61.0-0.90.9
Heart weight0.60.91.3-0.5-1.1-0.90.8-0.9-0.91.1-1.1
Delay discount hyperbolic model param1.71.93.1-0.9-1.2-1.21.1-1.8-1.41.6-1.6
Intermittent access intake day 1-15 change0.30.61.00.9-1.0-1.01.0-0.40.50.4-0.4
Intermittent access intake escalation0.30.61.11.0-1.0-1.01.0-0.30.60.4-0.3
Intermittent access intake escalation 21.31.54.12.0-1.3-1.21.40.31.50.10.0
Intermitt. access day 1 inactive lever presses0.10.61.61.3-0.8-0.70.90.10.90.00.1
Intermitt. access day 15 inactive lever presses1.73.54.6-0.4-2.1-2.12.0-2.1-1.22.1-2.1
Intermitt. access escalation Index0.20.30.9-1.00.50.4-0.7-0.4-0.80.1-0.2
Intermittent access day 1 total infusions0.10.20.4-0.4-0.2-0.20.1-0.6-0.50.4-0.4
Intermittent access day 15 total infusions0.10.20.50.2-0.5-0.50.3-0.7-0.00.4-0.4
Intermittent access terminal intake (last 3 days)0.60.81.51.2-1.2-1.21.1-0.30.70.5-0.4
Intermittent access total infusions0.10.10.20.4-0.4-0.40.3-0.30.20.2-0.1
Intermittent access day 1 locomotion0.00.10.10.30.00.1-0.20.30.3-0.20.3
Intermittent access day 15 total locomotion0.40.71.51.2-1.0-0.91.00.10.80.3-0.2
Intermittent access total locomotion0.40.50.90.5-1.0-0.90.8-0.40.20.6-0.5
Intermittent access standard deviation0.40.81.4-0.5-0.8-0.80.5-1.2-0.81.0-1.1
Left kidney weight2.511.725.53.0-4.8-4.65.0-0.51.22.8-2.5
Right kidney weight4.018.438.33.2-6.2-5.76.2-1.10.93.7-3.5
Cocaine induced anxiety0.60.91.4-0.2-1.2-1.11.1-0.1-0.61.2-1.2
Post-drug Anxiety1.21.32.2-0.5-1.3-1.31.1-0.3-1.01.5-1.5
Baseline Anxiety0.20.30.6-0.60.60.6-0.8-0.4-0.3-0.30.2
Tail length0.20.91.8-1.01.31.3-1.4-0.4-0.3-0.70.5
Length with tail0.00.10.20.30.20.30.00.50.5-0.40.4
Length without tail0.41.33.31.8-0.7-0.41.21.31.6-0.50.6
Times rat made contact with spout3.03.56.9-1.8-1.2-1.20.8-2.6-2.32.1-2.2
Lifetime Intake0.10.20.30.3-0.5-0.50.4-0.40.00.4-0.3
Liver weight, left0.61.02.51.6-0.6-0.20.61.51.4-0.60.7
Liver weight, right0.20.40.70.60.30.5-0.40.60.8-0.80.8
Locomotor activity0.81.33.31.8-0.3-0.20.71.51.8-0.70.8
Locomotor testing distance0.40.71.3-0.31.11.1-1.10.60.3-0.90.8
Locomotor testing rearing2.04.07.92.40.91.0-0.62.32.8-2.22.3
Locomotion in novel chamber3.03.89.5-1.4-1.5-1.51.0-3.1-1.92.2-2.2
Locomotion in novel chamber post-restriction0.30.40.90.80.30.4-0.60.41.0-0.80.8
Fecal boli incidents, locomotor time 10.20.30.8-0.50.80.7-0.90.2-0.2-0.40.4
Change in fecal boli incidents, locomotor task0.20.20.40.5-0.5-0.60.50.10.20.4-0.3
Time >=10cm from walls, locomotor time 10.40.40.90.9-0.6-0.50.60.80.8-0.00.1
Bouts of movement, locomotor time 10.80.93.1-0.3-0.7-0.90.5-1.8-0.61.0-0.9
Total resting periods, locomotor time 10.60.73.4-0.5-0.3-0.40.0-1.8-0.70.7-0.7
Rest time, locomotor task time 11.21.45.0-1.50.0-0.1-0.1-2.2-1.50.9-1.0
Distance moved, locomotor task time 10.60.82.61.3-0.4-0.30.61.61.2-0.40.5
Vertical activity count, locomotor time 10.71.64.22.0-0.9-0.91.21.71.6-0.30.4
Time >=10cm from walls, locomotor time 20.91.42.91.6-1.4-1.41.70.51.00.5-0.4
Bouts of movement, locomotor time 20.20.30.9-0.40.60.5-1.0-0.5-0.2-0.30.3
Total resting periods, locomotor time 20.20.31.0-0.30.60.6-1.0-0.4-0.1-0.40.4
Rest time, locomotor task time 20.91.23.2-1.80.80.8-1.2-1.2-1.40.2-0.3
Distance moved, locomotor task time 21.41.74.42.1-1.3-1.31.70.81.50.10.0
Vertical activity count, locomotor time 21.42.05.02.2-1.4-1.51.90.81.50.10.0
Light reinforcement 10.40.92.41.5-1.0-0.61.10.51.3-0.20.3
Light reinforcement 21.82.87.52.7-1.9-1.51.81.22.0-0.00.2
Bone: marrow area0.30.72.11.4-0.7-0.30.60.71.3-0.50.6
Bone: maximum diameter1.22.35.52.4-1.8-1.51.12.01.50.10.1
Bone: maximum force0.20.31.20.7-0.1-0.0-0.21.10.6-0.30.4
Bone: maximum moment0.10.20.80.40.10.2-0.30.90.4-0.40.4
Mean time between licks in bursts0.81.94.0-2.01.71.7-1.8-0.3-1.3-0.50.4
Mean num. licks in bursts0.40.62.2-0.6-0.4-0.50.2-1.5-0.80.8-0.8
Cd content in liver0.50.50.90.30.80.8-0.8-0.10.6-0.90.9
Co content in liver0.40.51.11.0-0.1-0.20.90.91.1-0.30.3
Cu content in liver1.72.05.7-2.30.10.2-1.0-1.3-2.41.1-1.1
Fe content in liver0.50.61.10.80.40.5-0.51.10.9-0.80.9
K content in liver0.00.00.1-0.3-0.00.30.2-0.1-0.1-0.10.1
Mg content in liver0.70.71.40.10.71.2-0.41.00.8-1.11.0
Mn content in liver0.10.10.50.3-0.10.20.70.20.5-0.30.3
Na content in liver3.13.35.50.42.02.2-2.10.91.1-2.32.3
Rb content in liver0.40.51.00.9-0.10.20.10.91.0-0.70.7
Se content in liver0.50.61.7-0.4-0.8-0.50.7-1.3-0.50.7-0.8
Sr content in liver0.90.82.0-1.41.00.9-1.1-0.3-1.0-0.10.1
Zn content in liver0.80.83.1-1.80.60.7-0.5-0.6-1.30.3-0.4
Bone: minimum diameter0.71.33.81.9-0.8-0.70.21.71.5-0.40.6
Time in familiar zone, hab. session 11.11.01.7-1.1-0.5-0.50.9-1.3-1.21.1-1.2
Time in novel zone, hab. session 11.11.11.60.71.10.9-1.01.01.1-1.21.3
Total zone transitions, hab. session 11.82.54.4-0.42.12.1-2.00.90.5-1.81.7
Total locomotion distance, hab. session 10.60.81.30.60.70.8-0.31.11.1-1.11.1
Locomotion velocity, hab. session 10.81.22.30.80.70.9-0.41.51.2-1.31.3
Time in familiar zone, hab. session 21.81.93.1-0.5-1.4-1.61.4-1.2-1.21.8-1.7
Time in novel zone, hab. session 21.41.42.7-0.21.61.6-1.30.40.6-1.41.3
Total zone transitions, hab. session 20.10.10.1-0.2-0.3-0.30.3-0.2-0.30.3-0.3
Total locomotion distance, hab. session 20.40.51.60.6-1.0-0.81.30.20.40.5-0.4
Locomotion velocity, hab. session 20.40.51.50.8-0.9-0.71.20.40.50.3-0.3
Novel to familiar place preference ratio0.60.72.1-1.50.20.2-0.1-0.9-1.30.5-0.7
Novelty place preference0.70.82.3-1.50.10.10.2-1.0-1.30.7-0.9
Time in novel zone, NPP test1.11.13.2-1.80.10.10.1-1.3-1.60.8-1.0
Total zone transitions, NPP test0.40.61.4-0.61.01.1-1.2-0.2-0.1-0.70.6
Total locomotion distance, NPP test0.20.30.80.70.10.3-0.00.70.9-0.70.6
Locomotion velocity, NPP test0.20.30.80.7-0.10.20.10.70.9-0.60.6
Intraocular pressure0.91.33.21.80.20.0-0.41.61.6-1.01.1
Delta distance traveled before/after self-admin3.43.64.7-0.4-2.2-2.12.1-2.2-1.22.2-2.2
Delta ambulatory time before/after self-admin2.12.63.8-0.4-1.7-1.71.7-2.0-1.11.8-1.8
Parametrial fat weight0.30.61.51.2-1.0-0.80.41.00.60.10.1
Pavlov. Cond. lever latency1.21.53.0-1.71.51.4-1.6-1.1-1.1-0.30.2
Pavlov. Cond. magazine entry latency0.10.10.60.30.10.1-0.30.70.3-0.30.4
Pavlov. Cond. change in total contacts1.01.03.51.4-0.4-0.20.11.91.2-0.60.8
Pavlov. Cond. index score0.30.31.10.9-0.5-0.40.21.10.5-0.10.2
Pavlov. Cond. latency score0.40.51.31.0-0.7-0.60.51.10.6-0.00.1
Pavlov. Cond. lever contacts1.21.42.61.6-1.5-1.31.51.11.00.3-0.2
Pavlov. Cond. magazine entry number0.30.41.3-0.5-0.3-0.20.6-1.2-0.50.5-0.6
Pavlov. Cond. intertrial magazine entries0.70.82.31.5-1.0-1.11.00.31.00.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.50.8-0.3-0.2-0.01.20.6-0.30.4
Pavlov. Cond. response bias0.30.40.90.9-0.6-0.60.50.90.60.10.0
Pavlov. Cond. lever latency0.81.12.5-0.91.61.6-1.20.2-0.1-1.00.9
Pavlov. Cond. magazine entry latency0.50.61.80.8-1.4-1.10.60.60.10.6-0.4
Pavlov. Cond. change in total contacts0.60.92.61.6-0.2-0.3-0.21.31.2-0.60.8
Pavlov. Cond. index score0.50.71.81.1-1.3-1.20.70.70.40.5-0.4
Pavlov. Cond. latency score0.91.12.91.1-1.7-1.51.10.40.30.9-0.7
Pavlov. Cond. lever contacts0.81.22.71.0-1.6-1.61.2-0.30.21.0-0.8
Pavlov. Cond. magazine entry number0.70.82.2-1.01.51.3-0.8-0.6-0.3-0.60.5
Pavlov. Cond. intertrial magazine entries0.30.51.9-1.10.30.30.1-1.4-0.70.4-0.5
Pavlov. Cond. lever-magazine prob. diff.0.60.82.01.1-1.4-1.20.80.60.40.6-0.4
Pavlov. Cond. response bias0.30.41.00.9-1.0-0.90.50.50.30.4-0.3
Time in closed arm before self-admin1.92.54.41.41.01.2-0.62.11.8-1.91.9
Time in closed arm after self-admin2.52.65.12.20.50.5-0.12.32.3-1.61.8
Time in open arm before self-admin0.50.61.5-1.00.1-0.0-0.5-1.2-1.00.6-0.6
Time in open arm after self-admin0.10.10.4-0.4-0.2-0.1-0.2-0.6-0.50.4-0.4
Bone: periosteal estimation0.92.05.72.4-1.1-0.70.51.91.9-0.60.8
Bone: periosteal perimeter2.13.610.43.2-1.3-1.00.82.62.6-0.81.1
Bone: post-yield work0.50.71.9-1.10.80.9-1.40.1-0.8-0.20.2
Progressive ratio test 1 active lever presses0.60.71.5-1.1-0.2-0.2-0.1-1.1-1.20.8-0.9
Progressive ratio test 1 breakpoint0.50.61.4-1.1-0.1-0.1-0.1-1.1-1.20.8-0.8
Progressive ratio test 1 inactive lever presses0.00.10.20.4-0.3-0.30.20.20.20.1-0.1
Progressive ratio test 2 active lever presses0.50.61.10.5-1.1-1.00.9-0.80.10.7-0.6
Progressive ratio test 2 breakpoint0.40.40.80.5-0.9-0.80.7-0.70.20.5-0.5
Progressive ratio test 2 inactive lever presses0.30.61.10.9-1.1-0.90.9-0.30.60.4-0.3
Incentive Sensitization - Responses0.71.02.71.6-1.2-1.01.20.21.20.10.0
Incentive Sensitization - Breakpoint0.70.92.51.6-1.1-1.01.10.21.20.10.0
Sum of active levers in priming session hrs 5-60.10.10.30.5-0.3-0.20.10.40.4-0.10.1
Progressive ratio0.20.30.5-0.1-0.7-0.60.7-0.2-0.30.6-0.7
Food seeking constrained by brief footshock1.51.84.61.3-1.9-1.72.1-0.00.61.0-0.9
Seeking ratio, punishment vs. effort0.40.51.21.10.00.00.20.91.0-0.60.7
Retroperitoneal fat weight1.45.810.93.2-3.3-3.13.10.91.71.2-1.0
Reaction time number correct0.20.41.0-0.50.70.9-1.0-0.1-0.1-0.60.5
Reaction time mean minus median0.10.20.70.6-0.3-0.20.50.80.5-0.10.1
Reaction time mean minus median AUC0.10.10.60.2-0.4-0.30.8-0.10.10.2-0.3
Reaction time num false alarms0.00.10.20.00.10.2-0.4-0.10.2-0.20.2
Reaction time num false alarms AUC0.10.10.5-0.3-0.2-0.1-0.4-0.7-0.40.2-0.2
Reaction time trials correct on left0.20.41.0-0.50.70.9-1.0-0.1-0.1-0.60.5
Reaction time trials on left0.20.41.1-0.60.70.9-1.0-0.1-0.2-0.60.5
Reaction time mean0.50.82.0-1.4-0.00.0-0.4-1.0-1.40.7-0.8
Reaction time mean AUC0.40.71.8-1.30.10.2-0.6-0.9-1.30.5-0.6
Median of all reaction times1.31.84.3-2.1-0.10.0-0.6-1.7-2.11.1-1.2
Reaction time omissions0.30.41.0-0.90.40.3-0.8-1.0-0.80.2-0.2
Reaction time false alarm rate0.00.10.10.1-0.3-0.40.0-0.4-0.10.3-0.2
Reaction time premature initiation rate2.53.49.83.1-1.7-1.62.11.22.4-0.20.4
Reaction time premature initiations0.91.65.12.3-1.0-0.91.20.81.9-0.40.6
Std. dev. reaction times0.10.20.3-0.2-0.5-0.50.4-0.0-0.40.6-0.6
Reaction time trials completed0.20.41.1-0.60.70.9-1.0-0.1-0.2-0.60.5
Reaction time trials AUC0.10.30.7-0.50.50.7-0.8-0.1-0.2-0.40.4
Run reversals in cocaine runway, females0.30.30.6-0.7-0.2-0.30.2-0.8-0.80.7-0.7
Run reversals in cocaine runway, males1.11.11.70.61.01.1-0.91.01.1-1.31.3
Latency to leave start box in cocaine runway1.61.82.5-0.1-1.6-1.61.6-1.2-0.81.6-1.5
Latency to leave start box in cocaine runway, F4.65.37.6-1.2-2.2-2.32.2-2.6-2.12.8-2.8
Latency to leave start box in cocaine runway, M1.21.12.81.40.20.3-0.21.71.4-1.01.1
Std. dev. time between licks in bursts0.70.92.71.6-0.6-0.61.00.91.4-0.30.3
Total sessions with >9 infusions0.40.40.7-0.4-0.6-0.60.4-0.9-0.60.8-0.8
Short access day 1 total inactive lever presses2.63.46.00.3-2.4-2.42.3-1.1-0.62.1-2.0
Short access day 10 total inactive lever presses1.94.69.92.5-2.9-2.83.10.11.21.3-1.1
Short access day 1 total infusions1.01.32.0-0.3-1.2-1.31.0-1.4-0.81.4-1.3
Short access day 10 total infusions0.60.81.30.2-1.1-1.11.0-0.8-0.31.0-0.9
Short access total infusions0.50.61.00.1-1.0-1.00.8-0.8-0.30.9-0.8
Short access day 1 locomotion1.01.32.4-0.3-1.2-1.21.0-1.5-0.81.3-1.3
Short access day 10 total locomotion0.40.71.40.5-1.2-1.20.9-0.5-0.00.9-0.8
Short access total locomotion0.30.40.80.3-0.9-0.90.6-0.5-0.10.7-0.6
One hour access (0.3 mA shock)0.70.82.21.5-0.9-0.81.10.31.1-0.00.1
Compulsive drug intake0.00.00.00.20.10.10.20.10.2-0.20.2
One hour access (shock baseline)0.30.41.31.2-0.7-0.60.6-0.10.9-0.00.1
Social response proportion0.50.61.80.70.40.4-0.51.30.7-0.80.8
Social responses0.40.51.30.80.20.3-0.01.10.9-0.70.8
Social time0.81.11.9-1.0-0.6-0.80.6-1.0-1.31.3-1.4
Soleus weight0.72.04.00.4-2.0-1.91.6-1.1-0.41.5-1.5
Bone: stiffness0.10.20.8-0.00.20.3-0.60.9-0.1-0.30.3
Tibialis anterior weight0.10.30.7-0.0-0.8-0.50.3-0.8-0.30.5-0.4
Time to tail flick, vehicle, before self-admin1.01.02.21.5-1.3-1.21.30.31.00.3-0.2
Time to tail flick, vehicle, after self-admin0.30.40.80.8-0.9-0.90.9-0.20.40.4-0.3
Time to tail flick, test, before self-admin0.30.30.60.6-0.8-0.80.70.40.20.4-0.3
Time to tail flick, test, after self-admin2.82.94.30.0-2.0-2.12.1-1.6-0.81.9-1.9
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.80.80.7-0.9-0.7-0.5-0.30.2
Delta time to tail flick, test, before/after SA0.50.51.4-0.5-0.4-0.50.6-1.2-0.60.7-0.8
Tibia length0.92.46.9-0.71.92.0-2.60.4-0.1-1.51.5
Ambulatory time before self-admin0.30.40.8-0.80.50.6-0.90.8-0.6-0.10.0
Ambulatory time after self-admin0.40.51.0-0.8-0.6-0.50.2-0.5-1.00.9-0.9
Bone: tissue strength1.01.12.8-1.71.21.3-0.9-0.9-0.9-0.30.1
Total heroin consumption0.20.20.70.9-0.3-0.2-0.0-0.30.7-0.30.3
Bone: trabecular number0.50.81.7-0.71.31.3-0.8-0.90.1-0.80.7
Bone: trabecular spacing1.01.42.90.8-1.7-1.71.40.6-0.01.2-1.0
Bone: trabecular thickness0.60.71.51.10.40.4-0.20.91.2-1.01.0
Bone: trabecular tissue density1.11.74.3-0.41.51.5-2.11.3-0.1-1.21.2
Water consumed over 24 hours0.10.10.20.1-0.3-0.30.2-0.4-0.00.3-0.3
Number of responses in last shaping day0.40.41.5-0.90.30.3-0.5-1.2-0.80.2-0.3