Hub : Genes

LOC120093732

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120093732	0.05	0.04	1.4e-06	0.07	0.07	0.07	0.07	3.9e-07	8.3e-07	3.9e-07	3.8e-07
2	Adipose	gene expression	LOC120093732	0.04	0.03	5.3e-06	0.05	0.04	0.04	0.05	2.1e-06	1.8e-05	2.0e-05	4.6e-06
3	Brain	alternative TSS	XR_005487406.1	0.04	0.04	8.5e-03	0.02	0.01	0.01	0.02	7.4e-03	1.3e-02	1.3e-02	6.6e-03
4	Brain	alternative TSS	XR_005487407.1	0.04	0.04	7.5e-03	0.02	0.01	0.01	0.02	7.3e-03	1.9e-02	1.7e-02	6.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	7.7	12.9	18.1	3.8	-4.2	3.1	-3.1
Area under the delay curve	1.1	1.1	1.8	1.3	-1.1	0.9	-0.9
BMI with tail	4.2	13.7	18.6	4.3	-3.8	3.3	-3.3
BMI without tail	0.2	0.3	0.5	0.7	-0.5	0.5	-0.5
Body weight	6.7	28.3	33.5	5.8	-5.5	5.0	-5.0
Weight adjusted by age	3.4	3.8	4.5	1.8	-1.8	2.1	-2.1
Bone surface	9.5	16.7	21.1	4.3	-4.6	3.7	-3.7
Bone volume	6.8	11.6	15.5	3.5	-3.9	3.1	-3.0
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.5	0.4	-0.4
Number of licking bursts	0.1	0.1	0.2	-0.5	0.1	0.3	-0.4
Context. condit. distance diff. score	0.5	0.6	0.7	0.8	-0.9	0.7	-0.7
Locomotion velocity, session 1	0.5	0.6	0.9	-0.6	1.0	-0.7	0.7
Locomotion distance, session 1	3.6	4.6	5.4	-1.9	2.0	-2.3	2.3
Locomotion velocity, session 2	0.3	0.4	0.6	-0.4	0.4	-0.8	0.8
Locomotion distance, session 2	3.0	4.2	4.7	-2.0	1.9	-2.2	2.2
Locomotion velocity, session 3	3.6	4.2	4.7	-2.1	1.8	-2.2	2.2
Locomotion distance, session 3	5.2	5.7	6.2	-2.5	2.3	-2.4	2.4
Stereotopy head waving bouts, day 3	1.1	1.3	1.8	1.0	-0.9	1.3	-1.3
Stereotopy head waving duration, day 3	0.4	0.5	0.7	0.6	-0.5	0.8	-0.8
Locomotion velocity, session 7	0.0	0.0	0.0	-0.2	0.1	-0.1	0.1
Locomotion distance, session 7	0.8	1.1	1.5	-1.2	1.1	-0.9	0.9
Stereotopy head waving bouts, day 7	1.2	1.4	1.9	1.0	-0.9	1.4	-1.4
Stereotopy head waving duration, day 7	1.6	2.0	2.3	1.4	-1.2	1.5	-1.5
Locomotion velocity, session 8	0.1	0.1	0.2	0.4	-0.3	0.1	-0.1
Locomotion distance, session 8	1.4	2.0	2.7	-1.3	1.1	-1.6	1.6
Degree of sensitization distance	0.9	0.9	1.1	1.0	-0.8	1.0	-1.0
Degree of sensitization stereotypy	0.6	0.6	0.9	0.7	-0.5	0.9	-0.9
Conditioned locomotion	0.2	0.2	0.5	-0.1	0.1	0.7	-0.7
Cocaine response after cond. corrected	0.3	0.3	0.6	0.2	0.2	-0.7	0.7
Cocaine response after cond. not corrected	1.4	1.5	2.2	-0.9	1.0	-1.4	1.5
Cocaine response before conditioning	4.2	5.0	7.8	-2.8	2.2	-1.9	1.9
Saline control response	0.0	0.0	0.2	-0.4	-0.0	-0.0	0.0
Bone: connectivity density	5.1	8.0	11.7	3.1	-3.4	2.4	-2.3
Bone: cortical apparent density	0.2	0.3	0.5	-0.7	0.7	-0.4	0.4
Bone: cortical area	9.7	14.6	16.5	4.0	-4.1	3.6	-3.6
Bone: cortical porosity	1.4	1.6	2.6	-1.6	1.5	-0.9	0.8
Bone: cortical porosity	2.0	2.1	3.3	-1.8	1.8	-1.0	1.0
Bone: cortical thickness	4.0	6.5	7.8	2.7	-2.8	2.3	-2.3
Bone: cortical thickness	0.2	0.2	0.4	0.5	-0.6	0.4	-0.4
Bone: cortical tissue density	0.4	0.5	0.7	-0.8	0.9	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.4	0.3	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.3	-0.3	-0.1	0.1
Condit. Reinf. active responses	0.8	1.0	1.1	-0.9	0.9	-1.0	1.0
Condit. Reinf. inactive responses	2.4	2.9	3.7	-1.9	1.8	-1.5	1.5
Incentive salience index mean	0.0	0.0	0.1	0.1	-0.3	0.0	-0.0
Condit. Reinf. lever presses	0.3	0.3	0.6	0.5	-0.7	0.6	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	-0.5	0.4	-0.6	0.6
Condit. Reinf. active responses	0.2	0.2	0.4	-0.6	0.5	-0.3	0.3
Condit. Reinf. inactive responses	0.6	0.7	1.3	-1.1	1.0	-0.6	0.5
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	0.1	-0.2	0.1
Condit. Reinf. lever reinforcers received	0.5	0.6	0.9	-1.0	0.8	-0.7	0.7
Conditioned reinforcement - actives	1.3	1.3	1.7	-1.3	1.1	-1.1	1.1
Conditioned reinforcement - inactives	1.4	1.6	1.7	-1.2	1.3	-1.3	1.3
Conditioned locomotion	0.2	0.2	0.4	-0.6	0.5	-0.2	0.2
Patch foraging indifference point 0 sec	1.4	2.2	2.7	-1.4	1.3	-1.6	1.6
Patch foraging indifference point AUC	0.1	0.2	0.3	-0.6	0.5	-0.2	0.2
Delay disc. indifference point, 0s delay	1.7	1.8	2.1	1.4	-1.1	1.4	-1.5
Delay disc. indifference point, 16s delay	1.6	1.6	1.8	1.3	-1.3	1.2	-1.2
Delay disc. indifference point, 2s delay	0.9	1.0	1.1	1.1	-0.9	1.1	-1.0
Delay disc. indifference point, 24s delay	1.6	1.5	1.8	1.3	-1.3	1.2	-1.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.7	-0.6	0.1	-0.1
Delay disc. indifference point, 8s delay	2.7	2.8	4.0	2.0	-1.7	1.5	-1.5
Indifference point function ln k	3.6	5.0	6.1	2.5	-2.3	2.1	-2.1
Indifference point function log k	3.6	5.0	6.1	2.5	-2.3	2.1	-2.1
Patch foraging total patch changes 0 sec	1.2	2.0	2.3	-1.4	1.3	-1.5	1.5
Patch foraging total patch changes 12 sec	1.2	1.6	2.1	-1.4	1.2	-1.2	1.2
Patch foraging total patch changes 18 sec	2.6	3.4	5.0	-2.2	1.9	-1.6	1.6
Patch foraging total patch changes 24 sec	0.7	0.8	1.5	-1.2	1.0	-0.6	0.6
Patch foraging total patch changes 6 sec	2.2	3.2	3.8	-2.0	1.6	-1.8	1.8
Patch foraging time to switch 0 sec	2.8	4.3	5.5	-2.4	2.2	-1.9	1.9
Patch foraging water rate 0 sec	4.0	6.4	7.6	2.8	-2.5	2.4	-2.4
Patch foraging water rate 12 sec	3.7	5.6	5.8	2.3	-2.4	2.4	-2.4
Patch foraging water rate 18 sec	0.6	0.7	1.0	1.0	-0.9	0.8	-0.8
Patch foraging water rate 24 sec	3.2	4.5	4.8	2.2	-2.0	2.2	-2.2
Patch foraging water rate 6 sec	4.2	6.1	6.7	2.6	-2.5	2.4	-2.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.6	-0.3	-0.0	0.1
Distance traveled before self-admin	0.6	0.7	1.0	-1.0	1.0	-0.6	0.6
Distance traveled after self-admin	0.2	0.2	0.3	-0.3	0.3	-0.6	0.6
Extensor digitorum longus weight	5.2	20.3	23.1	4.8	-4.6	4.3	-4.3
Bone: elastic displacement	4.4	5.0	6.0	-2.4	2.3	-2.1	2.0
Bone: elastic work	0.1	0.1	0.3	-0.5	0.2	-0.1	0.1
Bone: endosteal estimation	6.8	14.8	15.2	3.9	-3.9	3.8	-3.8
Bone: endosteal perimeter	6.4	13.3	14.1	3.6	-3.8	3.6	-3.6
Epididymis fat weight	0.3	0.7	1.2	1.1	-0.9	0.6	-0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.4	-0.3	0.3
Delta time in open arm before/after self-admin	3.5	3.4	4.5	-2.0	2.1	-1.6	1.6
Diff in mean of infusions in LGA sessions	0.8	0.9	1.1	1.0	-1.0	0.8	-0.8
Delay discount exponential model param	0.9	0.9	1.5	-1.2	1.0	-0.8	0.8
Extinction: sum of active levers before priming	0.4	0.4	0.5	0.6	-0.5	0.7	-0.7
Active lever presses in extinction session 6	0.3	0.3	0.7	0.6	-0.8	0.2	-0.2
Bone: final force	8.8	14.2	18.1	4.0	-4.3	3.4	-3.3
Bone: final moment	8.7	14.2	18.1	4.1	-4.3	3.3	-3.3
Food consumed during 24 hour testing period	0.7	0.9	1.7	1.1	-1.3	0.6	-0.5
Glucose	0.3	0.4	0.5	0.5	-0.5	0.7	-0.7
Heart weight	0.0	0.1	0.1	-0.1	0.2	-0.3	0.3
Delay discount hyperbolic model param	0.8	0.9	1.4	-1.2	1.0	-0.8	0.7
Intermittent access intake day 1-15 change	1.2	1.2	1.4	-0.9	1.0	-1.2	1.2
Intermittent access intake escalation	0.9	0.9	1.2	-0.7	0.9	-1.1	1.1
Intermittent access intake escalation 2	1.3	1.3	1.6	-1.0	1.0	-1.3	1.3
Intermitt. access day 1 inactive lever presses	2.4	2.5	3.9	-2.0	1.8	-1.3	1.2
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.1	-1.0	1.0	-0.7	0.7
Intermitt. access escalation Index	0.1	0.1	0.2	-0.4	0.3	-0.3	0.3
Intermittent access day 1 total infusions	1.2	1.4	1.5	-1.1	1.2	-1.2	1.2
Intermittent access day 15 total infusions	2.0	2.2	2.3	-1.5	1.5	-1.5	1.5
Intermittent access terminal intake (last 3 days)	2.1	2.3	2.4	-1.5	1.5	-1.5	1.5
Intermittent access total infusions	2.0	2.3	2.4	-1.5	1.5	-1.5	1.5
Intermittent access day 1 locomotion	0.4	0.5	0.9	-1.0	0.9	-0.3	0.3
Intermittent access day 15 total locomotion	0.4	0.5	1.1	-1.0	0.7	-0.3	0.3
Intermittent access total locomotion	1.4	1.6	3.0	-1.7	1.5	-0.9	0.8
Intermittent access standard deviation	0.6	0.7	0.8	-0.6	0.8	-0.9	0.9
Left kidney weight	0.2	0.5	1.2	1.1	-0.8	0.1	-0.1
Right kidney weight	2.8	7.7	9.1	3.0	-2.8	2.6	-2.6
Cocaine induced anxiety	1.2	1.3	1.5	1.0	-1.1	1.2	-1.2
Post-drug Anxiety	4.2	4.7	5.2	2.1	-2.0	2.3	-2.3
Baseline Anxiety	1.1	1.1	1.6	1.2	-1.1	1.0	-1.0
Tail length	0.0	0.0	0.1	-0.4	0.1	0.0	-0.0
Length with tail	2.0	7.2	7.9	2.7	-2.8	2.6	-2.6
Length without tail	6.1	13.3	17.3	4.2	-3.9	3.3	-3.2
Times rat made contact with spout	0.1	0.1	0.2	0.1	-0.1	-0.4	0.4
Lifetime Intake	1.6	1.8	1.9	-1.4	1.4	-1.3	1.3
Liver weight, left	1.9	3.1	3.4	1.8	-1.8	1.7	-1.7
Liver weight, right	2.1	3.5	3.9	2.0	-1.9	1.8	-1.8
Locomotor activity	0.6	1.0	1.3	-1.1	1.1	-0.9	0.9
Locomotor testing distance	2.0	3.3	4.1	-2.0	1.9	-1.7	1.6
Locomotor testing rearing	1.4	2.2	3.4	-1.8	1.5	-1.3	1.2
Locomotion in novel chamber	0.8	0.9	1.1	1.0	-0.8	1.0	-1.0
Locomotion in novel chamber post-restriction	0.4	0.5	0.7	0.8	-0.6	0.7	-0.7
Fecal boli incidents, locomotor time 1	1.9	2.0	3.1	-0.9	1.2	-1.7	1.8
Change in fecal boli incidents, locomotor task	0.9	0.8	1.1	0.9	-0.7	1.0	-1.0
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.7	0.8	-0.7	0.5	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.4	-0.5	0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.2	0.0	-0.3	0.4
Rest time, locomotor task time 1	0.2	0.2	0.2	-0.4	0.4	-0.4	0.5
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	0.3	-0.1	0.0
Vertical activity count, locomotor time 1	0.8	0.9	1.4	1.2	-1.0	0.7	-0.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	-0.5	0.7	-0.6	0.6
Bouts of movement, locomotor time 2	3.4	3.7	3.9	1.9	-1.8	2.0	-2.0
Total resting periods, locomotor time 2	3.8	4.0	4.2	2.0	-1.9	2.0	-2.1
Rest time, locomotor task time 2	0.2	0.2	0.3	0.5	-0.6	0.4	-0.4
Distance moved, locomotor task time 2	0.4	0.4	0.7	-0.6	0.9	-0.5	0.5
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.5	-0.3	0.4	-0.4
Light reinforcement 1	1.8	3.2	5.2	-2.3	2.0	-1.4	1.3
Light reinforcement 2	0.6	0.9	1.2	-1.1	1.0	-0.8	0.8
Bone: marrow area	6.8	14.7	15.2	3.9	-3.9	3.8	-3.8
Bone: maximum diameter	4.5	8.2	8.9	3.0	-2.9	2.8	-2.8
Bone: maximum force	12.0	20.8	25.0	4.7	-5.0	4.3	-4.2
Bone: maximum moment	11.8	20.4	24.7	4.7	-5.0	4.2	-4.2
Mean time between licks in bursts	0.3	0.4	0.5	-0.7	0.7	-0.5	0.5
Mean num. licks in bursts	0.5	0.6	1.1	0.1	0.2	-1.0	1.1
Cd content in liver	0.3	0.3	0.3	-0.5	0.6	-0.6	0.6
Co content in liver	0.0	0.0	0.1	-0.3	0.1	-0.1	0.1
Cu content in liver	1.2	1.4	1.8	1.3	-1.3	1.0	-1.0
Fe content in liver	0.1	0.1	0.1	-0.2	0.2	-0.3	0.3
K content in liver	0.7	0.7	1.4	1.2	-0.9	0.6	-0.6
Mg content in liver	0.0	0.0	0.0	0.1	0.0	0.0	-0.0
Mn content in liver	0.1	0.1	0.1	0.3	-0.2	0.3	-0.3
Na content in liver	0.0	0.0	0.1	0.2	0.2	0.1	-0.1
Rb content in liver	0.0	0.0	0.0	0.1	0.2	0.0	-0.0
Se content in liver	0.4	0.5	0.6	-0.7	0.7	-0.8	0.8
Sr content in liver	1.0	0.9	1.2	1.1	-0.9	1.0	-1.0
Zn content in liver	0.4	0.5	0.9	-0.6	0.9	-0.6	0.6
Bone: minimum diameter	8.4	15.7	16.5	3.9	-4.1	4.0	-4.0
Time in familiar zone, hab. session 1	0.6	0.6	0.9	-0.4	0.7	-0.9	0.9
Time in novel zone, hab. session 1	0.8	0.7	1.2	0.3	-0.7	1.1	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.6	-0.8	0.4	-0.5	0.5
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.4	0.2	-0.2	0.3
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	0.0	-0.1	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	-0.4	0.0	-0.0
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	0.5	0.3	-0.3
Total zone transitions, hab. session 2	0.3	0.4	0.6	-0.4	0.3	-0.8	0.8
Total locomotion distance, hab. session 2	0.3	0.4	0.5	-0.5	0.5	-0.7	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.2	0.3	-0.6	0.6
Novel to familiar place preference ratio	2.3	2.3	2.9	1.1	-1.6	1.7	-1.7
Novelty place preference	1.8	1.8	2.3	0.8	-1.4	1.5	-1.5
Time in novel zone, NPP test	1.5	1.6	2.2	0.6	-1.2	1.5	-1.5
Total zone transitions, NPP test	1.4	1.9	2.4	-1.2	1.2	-1.5	1.5
Total locomotion distance, NPP test	2.3	3.2	3.6	-1.9	1.7	-1.8	1.8
Locomotion velocity, NPP test	1.4	1.9	2.1	-1.4	1.2	-1.4	1.5
Intraocular pressure	7.6	10.5	13.6	-3.7	3.5	-2.9	2.9
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	-0.2	-0.2	0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2
Parametrial fat weight	1.8	3.4	4.0	-1.4	1.9	-2.0	2.0
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.2	0.0	-0.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.1	-0.0	-0.4	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.3	0.2	-0.2
Pavlov. Cond. index score	0.1	0.2	0.3	0.3	-0.5	0.4	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	-0.5	0.3	-0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.6	0.3	-0.4	0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.0	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.7	-0.7	0.8	-0.8	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	0.7	-0.9	0.6	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	0.1	-0.4	0.4
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.2	-0.1	-0.0	0.0
Pavlov. Cond. magazine entry latency	0.5	0.6	0.8	0.6	-0.9	0.8	-0.8
Pavlov. Cond. change in total contacts	1.1	1.5	2.0	1.2	-1.4	1.2	-1.1
Pavlov. Cond. index score	0.3	0.4	0.5	0.4	-0.7	0.7	-0.7
Pavlov. Cond. latency score	0.4	0.5	0.5	0.5	-0.7	0.7	-0.7
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.6	0.4	-0.4	0.4
Pavlov. Cond. magazine entry number	1.9	2.3	2.7	-1.2	1.6	-1.7	1.6
Pavlov. Cond. intertrial magazine entries	4.0	5.2	6.1	-2.0	2.5	-2.3	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	0.6	-0.9	1.0	-1.0
Pavlov. Cond. response bias	0.0	0.1	0.2	-0.5	0.2	-0.1	0.1
Time in closed arm before self-admin	1.6	1.8	2.3	1.1	-1.3	1.5	-1.5
Time in closed arm after self-admin	0.5	0.5	0.6	0.6	-0.8	0.7	-0.7
Time in open arm before self-admin	1.2	1.3	1.6	1.1	-1.3	1.1	-1.1
Time in open arm after self-admin	0.1	0.2	0.3	-0.5	0.5	-0.2	0.2
Bone: periosteal estimation	11.2	23.2	25.1	5.0	-5.0	4.6	-4.6
Bone: periosteal perimeter	9.2	15.4	17.8	4.1	-4.2	3.7	-3.6
Bone: post-yield work	7.7	10.5	10.6	3.3	-3.2	3.2	-3.2
Progressive ratio test 1 active lever presses	2.6	2.7	3.4	-1.9	1.7	-1.5	1.5
Progressive ratio test 1 breakpoint	2.2	2.3	3.0	-1.7	1.6	-1.4	1.4
Progressive ratio test 1 inactive lever presses	1.9	2.1	2.9	-1.7	1.5	-1.3	1.3
Progressive ratio test 2 active lever presses	1.1	1.1	1.6	-1.3	1.2	-0.9	0.8
Progressive ratio test 2 breakpoint	1.5	1.7	2.4	-1.5	1.5	-1.1	1.1
Progressive ratio test 2 inactive lever presses	2.1	2.4	2.9	-1.7	1.7	-1.4	1.4
Incentive Sensitization - Responses	0.1	0.1	0.1	0.3	-0.2	0.4	-0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.1	-0.0	0.2	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.5	-0.3	0.3
Progressive ratio	0.1	0.1	0.1	0.1	-0.0	-0.4	0.4
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	0.1	-0.2	0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.0	0.0	0.3	-0.4
Retroperitoneal fat weight	0.4	1.4	2.1	-0.6	1.0	-1.4	1.5
Reaction time number correct	0.5	0.7	0.7	0.8	-0.9	0.8	-0.8
Reaction time mean minus median	9.3	12.4	13.3	-3.4	3.4	-3.6	3.6
Reaction time mean minus median AUC	6.8	8.9	9.8	-2.8	2.8	-3.1	3.1
Reaction time num false alarms	2.3	3.1	3.2	-1.7	1.8	-1.8	1.8
Reaction time num false alarms AUC	3.6	5.0	5.3	-2.1	2.2	-2.3	2.3
Reaction time trials correct on left	0.5	0.7	0.7	0.8	-0.9	0.8	-0.8
Reaction time trials on left	0.3	0.4	0.5	0.7	-0.7	0.7	-0.6
Reaction time mean	0.6	0.8	0.9	-0.9	0.9	-0.9	0.9
Reaction time mean AUC	0.4	0.6	0.6	-0.7	0.8	-0.7	0.8
Median of all reaction times	0.0	0.0	0.1	0.0	-0.2	0.3	-0.2
Reaction time omissions	9.7	13.3	14.8	-3.9	3.7	-3.5	3.5
Reaction time false alarm rate	2.8	3.9	4.2	-1.9	2.0	-2.1	2.1
Reaction time premature initiation rate	4.1	5.4	6.5	-2.5	2.5	-2.1	2.1
Reaction time premature initiations	2.4	3.3	4.1	-2.0	2.0	-1.6	1.6
Std. dev. reaction times	6.5	9.1	9.7	-3.0	2.9	-3.1	3.1
Reaction time trials completed	0.3	0.4	0.5	0.7	-0.7	0.7	-0.6
Reaction time trials AUC	0.7	1.0	1.1	1.0	-1.0	1.0	-1.0
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.5	0.3	-0.1	0.1
Run reversals in cocaine runway, males	1.3	1.2	1.7	-1.3	1.1	-1.0	1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0
Latency to leave start box in cocaine runway, F	1.4	1.5	2.3	-1.5	1.3	-1.0	1.0
Latency to leave start box in cocaine runway, M	1.7	1.6	2.5	1.6	-1.3	1.1	-1.0
Std. dev. time between licks in bursts	0.6	0.8	1.1	-1.1	1.0	-0.7	0.7
Total sessions with >9 infusions	0.2	0.2	0.4	-0.5	0.6	-0.4	0.4
Short access day 1 total inactive lever presses	0.8	0.9	1.2	-1.0	1.1	-0.8	0.8
Short access day 10 total inactive lever presses	0.3	0.3	0.6	-0.8	0.7	-0.3	0.2
Short access day 1 total infusions	0.0	0.0	0.1	0.2	-0.1	0.2	-0.1
Short access day 10 total infusions	0.5	0.6	0.7	-0.7	0.7	-0.8	0.9
Short access total infusions	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3
Short access day 1 locomotion	0.2	0.2	0.3	0.2	-0.3	0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.3	-0.4	0.4	0.5	-0.5
Short access total locomotion	0.1	0.1	0.1	-0.4	0.3	0.3	-0.3
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	0.3	-0.5	0.5
Compulsive drug intake	0.5	0.5	0.6	0.8	-0.8	0.6	-0.6
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1
Social response proportion	0.3	0.4	0.5	-0.7	0.6	-0.5	0.5
Social responses	7.9	10.2	12.5	-3.5	3.3	-2.9	2.9
Social time	0.4	0.6	0.8	-0.7	0.5	-0.9	0.9
Soleus weight	0.7	2.1	2.3	1.5	-1.3	1.5	-1.5
Bone: stiffness	14.9	23.6	27.4	5.1	-5.2	4.5	-4.5
Tibialis anterior weight	2.1	7.2	8.1	2.8	-2.6	2.6	-2.6
Time to tail flick, vehicle, before self-admin	1.3	1.4	1.6	-1.2	0.9	-1.3	1.3
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.7	0.2	-0.4	0.8	-0.8
Time to tail flick, test, before self-admin	0.6	0.6	0.9	-0.9	0.9	-0.6	0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.3	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	0.6	-0.5	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.5	0.4	0.6	0.7	-0.8	0.5	-0.5
Tibia length	7.1	20.0	21.6	4.5	-4.7	4.4	-4.4
Ambulatory time before self-admin	2.8	2.9	4.0	-2.0	1.9	-1.5	1.4
Ambulatory time after self-admin	1.1	1.3	1.5	-1.2	1.2	-1.0	1.0
Bone: tissue strength	0.6	0.6	0.7	0.6	-0.9	0.8	-0.8
Total heroin consumption	3.3	3.9	4.6	1.6	-1.9	2.1	-2.1
Bone: trabecular number	3.5	5.5	9.3	2.6	-3.0	1.7	-1.7
Bone: trabecular spacing	1.0	1.2	2.7	-1.2	1.7	-0.7	0.6
Bone: trabecular thickness	0.3	0.3	0.5	-0.5	0.1	-0.7	0.7
Bone: trabecular tissue density	0.0	0.1	0.2	-0.5	0.2	0.1	-0.1
Water consumed over 24 hours	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2
Number of responses in last shaping day	0.5	0.5	0.6	0.7	-0.7	0.8	-0.8