Hub : Genes

LOC120093728

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	LOC120093728	0.24	0.18	2.3e-03	0.09	0.17	0.03	0.1	1.6e-02	1.5e-03	1.1e-01	1.1e-02
2	BLA	gene expression	LOC120093728	0.09	0.07	4.0e-05	0.09	0.08	0.08	0.03	1.1e-05	3.1e-05	4.5e-05	1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	7.2	12.0	12.7	-3.6	3.4
Area under the delay curve	1.2	1.3	1.6	-1.3	1.0
BMI with tail	4.6	14.8	15.1	-3.9	3.8
BMI without tail	0.0	0.0	0.0	-0.2	0.2
Body weight	6.6	27.8	29.2	-5.4	5.1
Weight adjusted by age	1.6	1.8	2.3	-1.5	1.1
Bone surface	10.1	17.8	18.0	-4.2	4.2
Bone volume	6.2	10.6	11.2	-3.3	3.2
Breakpoint value in progressive ratio session	0.5	0.6	0.8	-0.6	0.9
Number of licking bursts	0.3	0.4	0.4	0.6	-0.6
Context. condit. distance diff. score	0.5	0.6	0.6	-0.7	0.8
Locomotion velocity, session 1	1.1	1.1	1.5	0.9	-1.2
Locomotion distance, session 1	3.5	4.4	5.1	1.9	-2.3
Locomotion velocity, session 2	0.2	0.2	0.3	0.4	-0.5
Locomotion distance, session 2	2.2	3.0	3.2	1.7	-1.8
Locomotion velocity, session 3	3.3	3.8	4.1	1.9	-2.0
Locomotion distance, session 3	4.8	5.2	5.6	2.4	-2.2
Stereotopy head waving bouts, day 3	0.8	1.0	1.0	-1.0	1.0
Stereotopy head waving duration, day 3	0.2	0.3	0.3	-0.5	0.5
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	-0.2
Locomotion distance, session 7	1.5	1.9	2.0	1.3	-1.4
Stereotopy head waving bouts, day 7	1.4	1.6	1.8	-1.1	1.3
Stereotopy head waving duration, day 7	2.4	2.9	3.3	-1.6	1.8
Locomotion velocity, session 8	0.3	0.4	0.4	-0.5	0.7
Locomotion distance, session 8	0.6	0.8	1.0	1.0	-0.8
Degree of sensitization distance	0.5	0.5	0.6	-0.8	0.6
Degree of sensitization stereotypy	1.1	1.2	1.6	-0.9	1.3
Conditioned locomotion	0.0	0.1	0.1	0.2	-0.2
Cocaine response after cond. corrected	0.0	0.1	0.1	-0.3	-0.1
Cocaine response after cond. not corrected	0.9	1.0	1.3	0.9	-1.1
Cocaine response before conditioning	5.8	7.0	8.5	2.9	-2.3
Saline control response	0.0	0.1	0.1	0.3	-0.0
Bone: connectivity density	5.8	9.1	9.3	-3.0	3.0
Bone: cortical apparent density	0.4	0.5	0.6	0.8	-0.7
Bone: cortical area	9.8	14.8	15.0	-3.9	3.8
Bone: cortical porosity	2.1	2.3	2.6	1.6	-1.4
Bone: cortical porosity	2.1	2.3	2.8	1.7	-1.3
Bone: cortical thickness	4.4	7.2	7.4	-2.6	2.7
Bone: cortical thickness	0.1	0.2	0.2	-0.5	0.3
Bone: cortical tissue density	0.5	0.7	0.8	0.9	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	0.2
Condit. Reinf. active responses	0.7	0.9	1.0	0.9	-1.0
Condit. Reinf. inactive responses	3.5	4.1	4.4	2.0	-2.1
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.5	0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	0.6	-0.9
Condit. Reinf. active responses	0.2	0.3	0.3	0.6	-0.4
Condit. Reinf. inactive responses	0.7	0.9	1.2	1.1	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.1	0.1	0.4
Condit. Reinf. lever reinforcers received	0.4	0.6	0.7	0.8	-0.7
Conditioned reinforcement - actives	1.1	1.1	1.2	1.1	-1.0
Conditioned reinforcement - inactives	0.9	1.0	1.2	0.9	-1.1
Conditioned locomotion	0.1	0.1	0.2	0.5	-0.2
Patch foraging indifference point 0 sec	1.3	2.1	2.2	1.5	-1.4
Patch foraging indifference point AUC	0.0	0.0	0.1	0.2	-0.2
Delay disc. indifference point, 0s delay	1.2	1.3	1.5	-1.2	1.1
Delay disc. indifference point, 16s delay	1.6	1.6	1.8	-1.3	1.2
Delay disc. indifference point, 2s delay	0.5	0.6	0.8	-0.9	0.6
Delay disc. indifference point, 24s delay	1.2	1.1	1.3	-1.2	1.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.7	0.4
Delay disc. indifference point, 8s delay	3.7	3.9	4.0	-2.0	1.9
Indifference point function ln k	2.7	3.7	4.0	-2.0	1.8
Indifference point function log k	2.7	3.7	4.0	-2.0	1.8
Patch foraging total patch changes 0 sec	1.1	1.9	2.1	1.5	-1.3
Patch foraging total patch changes 12 sec	0.8	1.1	1.3	1.1	-0.9
Patch foraging total patch changes 18 sec	2.6	3.3	3.9	2.0	-1.7
Patch foraging total patch changes 24 sec	1.0	1.2	1.3	1.2	-1.0
Patch foraging total patch changes 6 sec	2.3	3.4	3.6	1.8	-1.9
Patch foraging time to switch 0 sec	2.9	4.4	4.8	2.2	-2.0
Patch foraging water rate 0 sec	5.2	8.4	9.1	-2.8	3.0
Patch foraging water rate 12 sec	3.8	5.8	6.4	-2.3	2.5
Patch foraging water rate 18 sec	1.0	1.4	1.7	-1.0	1.3
Patch foraging water rate 24 sec	4.9	6.8	8.4	-2.3	2.9
Patch foraging water rate 6 sec	5.3	7.7	8.3	-2.7	2.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.5	0.4
Distance traveled before self-admin	0.9	1.0	1.1	1.0	-1.0
Distance traveled after self-admin	0.1	0.2	0.3	-0.0	0.6
Extensor digitorum longus weight	6.3	25.0	25.7	-5.1	4.9
Bone: elastic displacement	4.3	4.9	5.5	2.3	-2.1
Bone: elastic work	0.0	0.0	0.0	0.2	-0.1
Bone: endosteal estimation	7.1	15.4	15.9	-4.0	3.9
Bone: endosteal perimeter	6.3	13.1	13.8	-3.7	3.5
Epididymis fat weight	0.9	2.1	2.5	-1.3	1.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.3	0.4
Delta time in open arm before/after self-admin	3.8	3.7	4.0	1.8	-2.0
Diff in mean of infusions in LGA sessions	1.1	1.2	1.2	-1.1	1.0
Delay discount exponential model param	1.0	1.0	1.3	1.2	-0.8
Extinction: sum of active levers before priming	0.5	0.5	0.7	-0.8	0.5
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.5	0.3
Bone: final force	10.2	16.4	16.6	-4.1	4.0
Bone: final moment	10.2	16.6	16.8	-4.1	4.1
Food consumed during 24 hour testing period	1.5	1.9	2.1	-1.3	1.5
Glucose	0.0	0.0	0.1	-0.3	0.2
Heart weight	0.0	0.0	0.0	-0.0	-0.2
Delay discount hyperbolic model param	0.9	0.9	1.2	1.1	-0.8
Intermittent access intake day 1-15 change	0.8	0.8	0.9	1.0	-0.8
Intermittent access intake escalation	0.5	0.5	0.6	0.7	-0.6
Intermittent access intake escalation 2	0.7	0.6	0.7	0.8	-0.8
Intermitt. access day 1 inactive lever presses	3.1	3.3	3.3	1.8	-1.8
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.7	1.1	-1.3
Intermitt. access escalation Index	0.2	0.2	0.2	0.4	-0.5
Intermittent access day 1 total infusions	1.5	1.7	1.9	1.3	-1.4
Intermittent access day 15 total infusions	2.7	3.0	3.3	1.6	-1.8
Intermittent access terminal intake (last 3 days)	2.5	2.8	2.9	1.6	-1.7
Intermittent access total infusions	2.2	2.5	2.5	1.6	-1.6
Intermittent access day 1 locomotion	1.2	1.2	1.3	1.2	-1.1
Intermittent access day 15 total locomotion	1.3	1.4	1.7	1.1	-1.3
Intermittent access total locomotion	2.1	2.4	2.6	1.6	-1.5
Intermittent access standard deviation	0.8	0.9	1.0	0.8	-1.0
Left kidney weight	0.5	1.4	1.5	-1.2	1.1
Right kidney weight	2.3	6.4	7.9	-2.8	2.2
Cocaine induced anxiety	1.7	2.0	2.6	-1.2	1.6
Post-drug Anxiety	5.4	6.1	6.9	-2.3	2.6
Baseline Anxiety	0.8	0.9	1.3	-1.1	0.7
Tail length	0.1	0.3	0.4	0.5	-0.6
Length with tail	1.8	6.5	7.4	-2.7	2.4
Length without tail	7.9	17.3	18.0	-4.2	4.1
Times rat made contact with spout	0.2	0.3	0.4	-0.4	0.7
Lifetime Intake	1.7	1.9	1.9	1.4	-1.4
Liver weight, left	2.4	3.8	4.1	-1.9	2.0
Liver weight, right	1.6	2.6	3.0	-1.7	1.5
Locomotor activity	1.0	1.6	1.8	1.2	-1.3
Locomotor testing distance	2.9	4.8	5.0	2.1	-2.2
Locomotor testing rearing	3.1	4.7	5.2	2.1	-2.3
Locomotion in novel chamber	0.5	0.6	0.9	-0.9	0.7
Locomotion in novel chamber post-restriction	1.0	1.2	1.6	-0.9	1.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.6	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.6	0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.0	-0.9	1.0
Bouts of movement, locomotor time 1	0.3	0.3	0.3	-0.5	0.6
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.1	0.0
Rest time, locomotor task time 1	0.2	0.2	0.4	0.2	-0.6
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.3	0.3
Vertical activity count, locomotor time 1	1.5	1.6	1.9	-1.2	1.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.4	-0.3
Bouts of movement, locomotor time 2	3.3	3.6	3.7	-1.9	1.9
Total resting periods, locomotor time 2	3.3	3.5	3.6	-1.9	1.9
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.4	0.0
Distance moved, locomotor task time 2	0.2	0.2	0.2	0.5	-0.4
Vertical activity count, locomotor time 2	0.3	0.3	0.3	-0.6	0.6
Light reinforcement 1	2.7	4.9	5.2	2.3	-2.1
Light reinforcement 2	1.3	1.7	2.0	1.2	-1.4
Bone: marrow area	7.2	15.6	16.0	-4.0	3.9
Bone: maximum diameter	4.4	8.1	8.5	-2.9	2.8
Bone: maximum force	12.2	21.1	21.8	-4.7	4.5
Bone: maximum moment	12.2	21.1	21.8	-4.7	4.5
Mean time between licks in bursts	0.4	0.6	0.8	0.9	-0.6
Mean num. licks in bursts	0.2	0.3	0.4	-0.4	0.6
Cd content in liver	0.5	0.5	0.7	0.6	-0.8
Co content in liver	0.2	0.2	0.2	0.5	-0.5
Cu content in liver	1.4	1.7	1.8	-1.3	1.3
Fe content in liver	0.1	0.1	0.1	0.4	-0.3
K content in liver	1.4	1.4	1.6	-1.3	1.1
Mg content in liver	0.0	0.0	0.0	-0.1	-0.1
Mn content in liver	0.1	0.1	0.2	-0.5	0.2
Na content in liver	0.1	0.1	0.2	-0.4	0.2
Rb content in liver	0.0	0.0	0.0	0.2	-0.1
Se content in liver	0.5	0.6	0.8	0.6	-0.9
Sr content in liver	1.0	0.9	0.9	-0.9	1.0
Zn content in liver	0.5	0.5	0.6	0.7	-0.8
Bone: minimum diameter	7.2	13.4	13.9	-3.7	3.6
Time in familiar zone, hab. session 1	0.3	0.2	0.3	0.4	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	0.5
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.6	-0.5
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.1	0.1
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.0
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	0.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	-0.4
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.5	-0.4
Locomotion velocity, hab. session 2	0.0	0.0	0.0	0.2	-0.2
Novel to familiar place preference ratio	0.7	0.7	0.8	-0.9	0.8
Novelty place preference	0.4	0.4	0.4	-0.6	0.6
Time in novel zone, NPP test	0.2	0.2	0.2	-0.5	0.5
Total zone transitions, NPP test	0.9	1.3	1.4	1.1	-1.2
Total locomotion distance, NPP test	2.5	3.4	3.5	1.9	-1.8
Locomotion velocity, NPP test	1.4	2.0	2.0	1.4	-1.4
Intraocular pressure	8.4	11.7	14.3	3.8	-3.0
Delta distance traveled before/after self-admin	0.6	0.6	0.9	-0.5	1.0
Delta ambulatory time before/after self-admin	0.5	0.6	1.0	-0.4	1.0
Parametrial fat weight	0.3	0.7	1.3	1.1	-0.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	-0.1
Pavlov. Cond. index score	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.6	-0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.0	-0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.7	0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.6	-0.8	0.8
Pavlov. Cond. response bias	0.0	0.0	0.0	0.2	-0.0
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.1	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	-0.5	0.3
Pavlov. Cond. change in total contacts	0.7	1.0	1.0	-1.0	1.0
Pavlov. Cond. index score	0.2	0.2	0.3	-0.4	0.5
Pavlov. Cond. latency score	0.2	0.3	0.3	-0.5	0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.5	-0.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	1.1	-0.9
Pavlov. Cond. intertrial magazine entries	1.3	1.7	2.7	1.6	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.6	0.7
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.2
Time in closed arm before self-admin	0.8	0.8	0.9	-0.9	1.0
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	0.4
Time in open arm before self-admin	0.5	0.6	0.7	-0.9	0.6
Time in open arm after self-admin	0.7	0.7	1.2	0.6	-1.1
Bone: periosteal estimation	11.4	23.6	24.1	-4.9	4.8
Bone: periosteal perimeter	10.4	17.2	18.3	-4.3	4.0
Bone: post-yield work	8.6	11.7	11.9	-3.4	3.4
Progressive ratio test 1 active lever presses	2.9	3.0	3.2	1.8	-1.7
Progressive ratio test 1 breakpoint	2.9	3.1	3.1	1.8	-1.7
Progressive ratio test 1 inactive lever presses	2.8	3.1	3.6	1.6	-1.9
Progressive ratio test 2 active lever presses	1.7	1.8	1.9	1.3	-1.4
Progressive ratio test 2 breakpoint	2.2	2.4	2.5	1.5	-1.6
Progressive ratio test 2 inactive lever presses	3.2	3.6	4.0	1.8	-2.0
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.0	-0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	-0.0
Progressive ratio	0.0	0.0	0.0	-0.1	-0.1
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.3	0.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	0.5
Retroperitoneal fat weight	0.0	0.0	0.0	0.1	-0.2
Reaction time number correct	1.0	1.4	2.1	-0.8	1.5
Reaction time mean minus median	8.7	11.5	11.7	3.4	-3.4
Reaction time mean minus median AUC	6.1	8.0	8.0	2.8	-2.8
Reaction time num false alarms	1.9	2.6	2.7	1.6	-1.6
Reaction time num false alarms AUC	3.1	4.3	4.4	2.1	-2.1
Reaction time trials correct on left	1.0	1.4	2.1	-0.8	1.5
Reaction time trials on left	0.7	1.0	1.6	-0.7	1.3
Reaction time mean	0.6	0.9	1.0	0.9	-1.0
Reaction time mean AUC	0.3	0.4	0.5	0.6	-0.7
Median of all reaction times	0.0	0.0	0.0	-0.1	-0.0
Reaction time omissions	9.0	12.3	13.0	3.4	-3.6
Reaction time false alarm rate	2.8	3.9	4.6	1.8	-2.1
Reaction time premature initiation rate	2.7	3.6	4.3	2.1	-1.7
Reaction time premature initiations	1.3	1.8	2.6	1.6	-1.0
Std. dev. reaction times	6.2	8.8	9.0	2.9	-3.0
Reaction time trials completed	0.7	1.0	1.6	-0.7	1.3
Reaction time trials AUC	1.3	1.8	2.6	-1.0	1.6
Run reversals in cocaine runway, females	0.7	0.7	0.9	0.7	-1.0
Run reversals in cocaine runway, males	1.1	1.0	1.1	1.0	-1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	-0.1
Latency to leave start box in cocaine runway, F	1.9	2.1	2.1	1.4	-1.5
Latency to leave start box in cocaine runway, M	2.6	2.4	2.6	-1.5	1.6
Std. dev. time between licks in bursts	0.6	0.7	1.0	1.0	-0.6
Total sessions with >9 infusions	0.6	0.7	0.9	0.7	-1.0
Short access day 1 total inactive lever presses	0.4	0.4	0.6	0.7	-0.5
Short access day 10 total inactive lever presses	0.2	0.2	0.2	0.5	-0.5
Short access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.3
Short access day 10 total infusions	0.6	0.6	0.7	0.8	-0.7
Short access total infusions	0.2	0.2	0.2	0.4	-0.4
Short access day 1 locomotion	0.2	0.2	0.4	0.2	-0.6
Short access day 10 total locomotion	0.2	0.2	0.2	0.5	-0.3
Short access total locomotion	0.2	0.2	0.2	0.5	-0.4
One hour access (0.3 mA shock)	0.3	0.4	0.6	0.4	-0.8
Compulsive drug intake	0.5	0.5	0.5	-0.7	0.7
One hour access (shock baseline)	0.1	0.1	0.2	0.1	-0.5
Social response proportion	1.3	1.4	2.1	0.9	-1.4
Social responses	9.8	12.6	13.8	3.4	-3.7
Social time	1.5	2.0	2.8	1.1	-1.7
Soleus weight	1.2	3.5	3.5	-1.9	1.9
Bone: stiffness	14.3	22.6	24.2	-4.9	4.6
Tibialis anterior weight	2.6	8.8	9.2	-3.0	2.9
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.0	0.9	-1.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	-0.2
Time to tail flick, test, before self-admin	1.4	1.4	1.9	0.9	-1.4
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.5	0.5	0.7	-0.5	0.8
Tibia length	5.9	16.7	16.8	-4.1	4.1
Ambulatory time before self-admin	3.6	3.8	4.1	2.0	-1.9
Ambulatory time after self-admin	0.4	0.5	0.9	0.9	-0.2
Bone: tissue strength	0.3	0.3	0.3	-0.6	0.6
Total heroin consumption	3.1	3.7	4.2	-1.8	2.1
Bone: trabecular number	4.0	6.2	6.7	-2.6	2.4
Bone: trabecular spacing	1.0	1.2	1.5	1.2	-1.0
Bone: trabecular thickness	0.5	0.6	0.8	0.7	-0.9
Bone: trabecular tissue density	0.1	0.1	0.2	0.4	-0.3
Water consumed over 24 hours	0.2	0.3	0.3	-0.5	0.6
Number of responses in last shaping day	0.2	0.2	0.2	-0.4	0.3