LOC120093706

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120093706	0.05	0.03	6.2e-04	0	0.03	0.01	0.03	1.8e-01	9.5e-04	1.3e-02	2.0e-03
2	pVTA	gene expression	LOC120093706	0.06	0.04	6.7e-03	0.06	0.05	0.02	0.05	1.6e-03	3.3e-03	4.4e-02	2.5e-03
3	Adipose	gene expression	LOC120093706	0.11	0.05	2.2e-11	0.05	0.1	0.1	0.1	1.8e-06	1.8e-11	5.7e-11	3.2e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.5	0.8	1.9	0.6	-1.4	0.4
Area under the delay curve	1.4	1.5	2.3	1.3	-1.5	0.6
BMI with tail	1.1	3.6	7.8	0.6	2.8	1.6
BMI without tail	1.1	2.4	4.3	-1.4	2.1	-0.8
Body weight	0.7	2.8	5.3	-1.6	2.3	-0.6
Weight adjusted by age	0.3	0.3	0.8	-0.3	0.9	0.4
Bone surface	0.2	0.3	0.7	0.2	-0.9	0.2
Bone volume	0.1	0.2	0.7	0.1	-0.8	-0.0
Breakpoint value in progressive ratio session	0.9	1.0	1.7	1.3	-0.2	1.2
Number of licking bursts	0.8	1.0	1.3	-0.9	-0.9	-1.1
Context. condit. distance diff. score	1.0	1.2	3.0	-0.7	1.7	-0.3
Locomotion velocity, session 1	1.4	1.5	2.6	-1.6	0.8	-1.1
Locomotion distance, session 1	0.6	0.8	1.2	-1.0	-0.4	-1.1
Locomotion velocity, session 2	2.2	2.6	3.3	-1.7	1.8	-1.3
Locomotion distance, session 2	0.2	0.3	0.5	0.7	-0.2	0.6
Locomotion velocity, session 3	6.2	7.2	9.6	-3.1	2.0	-2.8
Locomotion distance, session 3	2.2	2.4	4.0	-1.8	0.2	-2.0
Stereotopy head waving bouts, day 3	0.9	1.1	2.8	-0.7	1.7	-0.2
Stereotopy head waving duration, day 3	1.6	1.9	5.0	-0.9	2.2	-0.2
Locomotion velocity, session 7	2.7	2.9	3.7	-1.7	1.9	-1.5
Locomotion distance, session 7	0.4	0.6	0.9	-0.8	0.3	-0.9
Stereotopy head waving bouts, day 7	1.7	2.0	3.2	-1.3	1.8	-1.0
Stereotopy head waving duration, day 7	0.8	0.9	1.3	-1.0	1.1	-0.8
Locomotion velocity, session 8	2.5	3.0	8.4	-0.7	2.9	-0.0
Locomotion distance, session 8	0.6	0.9	1.6	-0.8	1.3	-0.7
Degree of sensitization distance	1.0	1.0	1.6	0.9	0.7	1.2
Degree of sensitization stereotypy	0.7	0.8	1.2	-0.9	1.1	-0.7
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.3	-0.1
Cocaine response after cond. corrected	0.4	0.4	0.6	-0.6	-0.8	-0.5
Cocaine response after cond. not corrected	1.0	1.1	1.5	-1.1	-0.8	-1.2
Cocaine response before conditioning	0.3	0.4	0.8	-0.6	-0.3	-0.9
Saline control response	0.2	0.2	0.6	-0.2	-0.8	-0.2
Bone: connectivity density	0.2	0.3	1.0	-0.1	-1.0	-0.1
Bone: cortical apparent density	0.5	0.6	0.8	0.9	-0.8	0.6
Bone: cortical area	0.4	0.6	1.1	0.2	1.1	0.8
Bone: cortical porosity	0.4	0.4	0.7	0.4	0.6	0.9
Bone: cortical porosity	0.4	0.5	0.8	0.5	0.6	0.9
Bone: cortical thickness	0.6	1.0	1.6	1.1	-0.2	1.3
Bone: cortical thickness	1.4	1.6	2.7	0.9	1.2	1.6
Bone: cortical tissue density	0.4	0.5	0.7	0.8	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.4	0.4	1.0	0.3	-1.0	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.6	0.5	-1.3	0.3
Condit. Reinf. active responses	0.6	0.8	2.0	-0.2	-1.4	-0.6
Condit. Reinf. inactive responses	0.7	0.8	1.3	-0.9	-0.7	-1.1
Incentive salience index mean	0.4	0.5	0.5	-0.7	-0.7	-0.6
Condit. Reinf. lever presses	1.3	1.8	3.2	-1.8	0.0	-1.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.4	0.2	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	-0.4	0.4
Condit. Reinf. active responses	0.5	0.6	1.2	0.3	1.1	0.8
Condit. Reinf. inactive responses	1.1	1.4	3.7	-0.0	1.9	0.6
Condit. Reinf. lever presses	0.3	0.4	1.0	0.0	1.0	0.3
Condit. Reinf. lever reinforcers received	0.3	0.5	0.7	0.4	0.8	0.8
Conditioned reinforcement - actives	1.1	1.1	1.4	-1.1	-0.8	-1.2
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.5	-0.1	-0.4
Conditioned locomotion	0.6	0.7	1.3	-1.1	0.6	-0.7
Patch foraging indifference point 0 sec	0.2	0.3	0.7	0.3	-0.9	0.2
Patch foraging indifference point AUC	0.0	0.1	0.1	0.3	-0.3	-0.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.2	0.2	0.2
Delay disc. indifference point, 16s delay	1.8	1.8	3.4	1.3	-1.9	0.7
Delay disc. indifference point, 2s delay	0.4	0.5	0.9	0.9	-0.4	0.7
Delay disc. indifference point, 24s delay	0.8	0.8	1.2	1.1	-0.0	1.0
Delay disc. indifference point, 4s delay	1.5	1.6	2.5	1.6	-1.2	0.9
Delay disc. indifference point, 8s delay	1.4	1.4	2.1	1.3	-1.5	0.6
Indifference point function ln k	0.9	1.2	1.9	-1.4	1.1	-0.7
Indifference point function log k	0.9	1.2	1.9	-1.4	1.1	-0.7
Patch foraging total patch changes 0 sec	0.2	0.4	1.0	0.3	-1.0	0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	0.3	0.4
Patch foraging total patch changes 18 sec	0.4	0.5	1.4	0.0	-1.2	-0.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.2	-0.1	-0.4
Patch foraging total patch changes 6 sec	0.6	0.9	1.3	1.0	-1.1	0.6
Patch foraging time to switch 0 sec	0.2	0.3	0.4	0.6	0.7	0.5
Patch foraging water rate 0 sec	0.0	0.1	0.2	0.0	0.4	0.2
Patch foraging water rate 12 sec	0.6	0.9	1.2	-1.1	-0.7	-1.1
Patch foraging water rate 18 sec	0.2	0.3	0.6	-0.4	-0.8	-0.3
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.2	0.3	0.3
Patch foraging water rate 6 sec	0.7	1.1	1.7	-1.1	-0.6	-1.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	0.9	0.9	-0.9	0.5
Distance traveled before self-admin	0.6	0.7	0.9	-0.9	0.7	-0.8
Distance traveled after self-admin	0.2	0.2	0.7	-0.1	0.8	0.2
Extensor digitorum longus weight	0.1	0.4	0.6	-0.7	0.8	-0.3
Bone: elastic displacement	0.6	0.7	1.0	-1.0	-0.1	-1.0
Bone: elastic work	1.0	1.3	3.7	-0.3	1.9	0.3
Bone: endosteal estimation	1.0	2.1	5.3	-1.0	2.3	-0.4
Bone: endosteal perimeter	1.2	2.6	5.1	-1.5	2.3	-0.7
Epididymis fat weight	0.0	0.1	0.2	-0.5	-0.1	-0.3
Delta time in closed arm before/after self-admin	0.6	0.5	0.9	0.8	0.2	1.0
Delta time in open arm before/after self-admin	2.6	2.5	4.1	-1.8	0.0	-2.0
Diff in mean of infusions in LGA sessions	2.2	2.4	4.0	1.7	-0.5	2.0
Delay discount exponential model param	1.4	1.4	2.3	-1.3	1.5	-0.6
Extinction: sum of active levers before priming	1.2	1.2	1.7	1.3	-0.8	1.1
Active lever presses in extinction session 6	1.7	1.7	2.5	1.3	1.0	1.6
Bone: final force	1.8	2.9	4.8	1.6	1.1	2.2
Bone: final moment	2.2	3.5	5.9	1.8	1.2	2.4
Food consumed during 24 hour testing period	1.0	1.3	3.2	-0.7	1.8	0.4
Glucose	0.4	0.6	0.7	0.8	-0.7	0.9
Heart weight	0.4	0.6	1.0	0.9	0.0	1.0
Delay discount hyperbolic model param	1.2	1.2	1.9	-1.3	1.4	-0.6
Intermittent access intake day 1-15 change	0.2	0.2	0.4	-0.3	-0.6	-0.1
Intermittent access intake escalation	0.1	0.1	0.2	-0.5	-0.4	-0.2
Intermittent access intake escalation 2	0.5	0.5	0.5	0.6	-0.7	0.7
Intermitt. access day 1 inactive lever presses	1.5	1.6	1.7	1.3	1.2	1.3
Intermitt. access day 15 inactive lever presses	1.4	1.5	2.5	1.0	1.0	1.6
Intermitt. access escalation Index	0.1	0.1	0.1	-0.1	-0.3	0.2
Intermittent access day 1 total infusions	1.5	1.7	3.0	-1.7	0.7	-1.3
Intermittent access day 15 total infusions	1.0	1.1	2.2	-1.5	0.3	-1.0
Intermittent access terminal intake (last 3 days)	0.9	0.9	1.9	-1.4	0.7	-0.7
Intermittent access total infusions	1.0	1.1	2.2	-1.5	0.8	-0.8
Intermittent access day 1 locomotion	1.6	1.7	2.8	-1.7	-0.1	-1.5
Intermittent access day 15 total locomotion	2.4	2.5	4.3	-2.1	0.6	-1.7
Intermittent access total locomotion	1.0	1.1	1.8	-1.3	0.7	-1.0
Intermittent access standard deviation	0.3	0.3	0.4	0.4	0.7	0.6
Left kidney weight	4.9	13.7	37.8	-1.8	6.1	0.2
Right kidney weight	4.6	13.0	37.2	-1.1	6.1	0.8
Cocaine induced anxiety	2.5	2.9	3.5	1.4	1.9	1.8
Post-drug Anxiety	5.0	5.6	8.1	2.6	1.4	2.8
Baseline Anxiety	0.7	0.8	2.2	0.3	-1.5	0.2
Tail length	1.6	4.8	7.6	-2.6	-0.3	-2.8
Length with tail	0.8	3.1	5.2	-2.3	0.2	-2.0
Length without tail	0.1	0.1	0.3	0.2	0.2	0.6
Times rat made contact with spout	0.7	0.8	1.4	-1.2	0.5	-0.8
Lifetime Intake	1.6	1.8	3.0	-1.7	1.1	-1.1
Liver weight, left	0.2	0.4	0.6	0.3	0.8	0.6
Liver weight, right	1.9	3.1	4.6	-2.2	0.7	-2.0
Locomotor activity	1.8	2.8	3.7	-1.9	1.9	-1.1
Locomotor testing distance	0.4	0.6	1.3	-1.1	0.4	-0.6
Locomotor testing rearing	0.9	1.4	2.4	-1.5	1.0	-1.0
Locomotion in novel chamber	3.4	4.2	6.2	-2.4	-0.8	-2.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	0.0	0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	-0.1	0.6	-0.2
Change in fecal boli incidents, locomotor task	0.5	0.5	0.6	-0.7	-0.7	-0.8
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.1	0.3	1.0	0.6
Bouts of movement, locomotor time 1	0.4	0.4	0.5	0.4	0.7	0.7
Total resting periods, locomotor time 1	1.1	1.2	2.1	1.1	0.5	1.4
Rest time, locomotor task time 1	0.4	0.5	1.3	-0.0	1.1	0.2
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	0.4	-0.0
Vertical activity count, locomotor time 1	0.3	0.4	0.5	0.6	-0.4	0.7
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.3	0.8	-0.1	1.2
Bouts of movement, locomotor time 2	1.5	1.7	3.0	1.7	-0.1	1.4
Total resting periods, locomotor time 2	1.5	1.6	3.0	1.7	-0.1	1.4
Rest time, locomotor task time 2	1.5	1.7	2.5	-1.0	-1.3	-1.6
Distance moved, locomotor task time 2	0.9	1.0	2.8	-0.3	1.7	0.3
Vertical activity count, locomotor time 2	0.8	0.8	2.0	0.1	1.4	0.7
Light reinforcement 1	1.0	1.8	3.0	-1.7	0.4	-1.5
Light reinforcement 2	0.9	1.2	2.3	-1.0	1.5	-0.5
Bone: marrow area	0.9	2.1	5.2	-0.9	2.3	-0.3
Bone: maximum diameter	1.7	3.1	8.6	-0.8	2.9	0.3
Bone: maximum force	2.2	3.7	5.5	1.7	1.7	2.3
Bone: maximum moment	2.6	4.4	6.6	1.9	1.8	2.6
Mean time between licks in bursts	0.6	0.8	1.8	-0.4	-1.4	-0.6
Mean num. licks in bursts	0.7	0.8	1.8	0.3	1.3	0.8
Cd content in liver	0.5	0.5	0.6	0.8	-0.8	0.6
Co content in liver	0.5	0.6	1.0	-1.0	0.6	-0.7
Cu content in liver	2.6	3.2	7.2	1.5	-2.7	0.4
Fe content in liver	0.0	0.0	0.1	0.2	0.0	0.3
K content in liver	0.9	0.9	1.5	1.2	-0.3	1.0
Mg content in liver	1.4	1.5	2.3	1.5	-0.5	1.4
Mn content in liver	1.1	1.3	1.9	-1.4	0.7	-1.2
Na content in liver	1.5	1.6	2.5	1.3	-1.6	0.7
Rb content in liver	1.4	1.7	2.2	1.5	-1.0	1.4
Se content in liver	0.4	0.5	0.6	-0.6	-0.8	-0.8
Sr content in liver	1.5	1.4	2.4	-1.3	-0.4	-1.5
Zn content in liver	0.5	0.5	1.0	-0.4	-1.0	-0.7
Bone: minimum diameter	0.8	1.6	1.9	-1.4	1.4	-0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.4	0.9	0.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.2	-0.4	0.3
Total zone transitions, hab. session 1	0.6	0.9	2.2	0.6	-1.5	0.1
Total locomotion distance, hab. session 1	0.4	0.6	1.0	-0.8	-0.1	-1.0
Locomotion velocity, hab. session 1	0.6	0.8	1.4	-1.0	0.1	-1.2
Time in familiar zone, hab. session 2	0.7	0.8	1.0	-1.0	-0.6	-0.9
Time in novel zone, hab. session 2	0.4	0.4	0.7	0.9	-0.2	0.7
Total zone transitions, hab. session 2	0.4	0.6	0.9	0.8	0.3	1.0
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.0	0.3	0.0
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.0	0.3	-0.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.4	-0.1	-0.3
Novelty place preference	0.4	0.4	0.6	-0.8	0.2	-0.6
Time in novel zone, NPP test	0.4	0.4	0.7	-0.8	0.2	-0.7
Total zone transitions, NPP test	0.3	0.4	0.9	0.6	-0.9	0.1
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.0	-0.1	-0.5
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.1	-0.3	-0.6
Intraocular pressure	1.2	1.7	2.6	-1.6	0.1	-1.6
Delta distance traveled before/after self-admin	0.2	0.2	0.2	-0.4	0.5	-0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.0	0.0	0.1
Parametrial fat weight	0.4	0.9	1.6	-0.9	-0.3	-1.3
Pavlov. Cond. lever latency	0.7	0.9	1.5	1.2	0.4	1.0
Pavlov. Cond. magazine entry latency	0.5	0.6	1.4	0.5	-1.2	0.5
Pavlov. Cond. change in total contacts	0.6	0.6	0.9	0.5	-1.0	0.8
Pavlov. Cond. index score	0.2	0.2	0.6	-0.1	-0.8	0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.4	-0.5	-0.1
Pavlov. Cond. lever contacts	1.1	1.3	2.3	-1.5	-0.4	-1.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	-0.4	1.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.9	0.6	-1.7	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.2	-0.9	-0.1
Pavlov. Cond. response bias	0.4	0.5	1.1	-0.5	-1.0	-0.3
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.1	-0.5	-0.3
Pavlov. Cond. magazine entry latency	3.0	3.5	5.8	2.4	-0.8	2.0
Pavlov. Cond. change in total contacts	1.7	2.3	3.5	1.7	0.6	1.9
Pavlov. Cond. index score	1.0	1.3	2.0	1.4	-0.0	1.4
Pavlov. Cond. latency score	1.3	1.7	2.5	1.6	0.1	1.6
Pavlov. Cond. lever contacts	0.6	0.8	1.1	0.8	0.7	1.0
Pavlov. Cond. magazine entry number	1.1	1.4	2.3	-1.5	-0.0	-1.4
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.0	0.8	0.7	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	1.2	0.0	1.1
Pavlov. Cond. response bias	0.8	1.1	1.7	1.2	0.3	1.3
Time in closed arm before self-admin	1.1	1.3	1.8	1.1	-1.3	0.9
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	-0.3	0.3
Time in open arm before self-admin	0.8	0.9	1.3	-0.9	0.6	-1.2
Time in open arm after self-admin	0.5	0.6	1.0	-0.6	0.7	-1.0
Bone: periosteal estimation	0.8	1.7	4.7	-0.5	2.2	0.3
Bone: periosteal perimeter	1.3	2.2	3.9	-1.5	2.0	-0.7
Bone: post-yield work	1.5	2.1	3.2	1.7	-0.3	1.8
Progressive ratio test 1 active lever presses	1.9	2.0	3.5	-1.9	0.2	-1.6
Progressive ratio test 1 breakpoint	1.8	1.9	3.2	-1.8	0.1	-1.5
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.7	-0.9	0.6	-0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.2	0.4	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	0.5	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	0.0	0.6	0.2
Incentive Sensitization - Responses	0.9	0.9	1.2	1.1	0.7	1.0
Incentive Sensitization - Breakpoint	0.9	0.9	1.1	1.0	0.9	1.0
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.4	1.2	0.4	1.1
Progressive ratio	0.0	0.0	0.1	-0.1	-0.1	-0.3
Food seeking constrained by brief footshock	0.3	0.4	0.9	0.2	0.9	0.5
Seeking ratio, punishment vs. effort	1.0	1.2	2.0	1.1	0.7	1.4
Retroperitoneal fat weight	0.9	2.9	5.3	-1.6	2.3	-0.8
Reaction time number correct	0.2	0.2	0.5	-0.3	-0.4	-0.7
Reaction time mean minus median	0.1	0.1	0.4	-0.2	-0.2	-0.6
Reaction time mean minus median AUC	0.5	0.6	1.1	-0.6	0.6	-1.0
Reaction time num false alarms	1.3	1.8	2.5	-1.6	-0.5	-1.6
Reaction time num false alarms AUC	1.8	2.5	3.7	-1.9	-0.5	-1.9
Reaction time trials correct on left	0.2	0.2	0.5	-0.3	-0.4	-0.7
Reaction time trials on left	0.2	0.2	0.5	-0.3	-0.4	-0.7
Reaction time mean	1.2	1.7	2.8	1.7	-1.1	1.1
Reaction time mean AUC	1.1	1.5	2.4	1.5	-1.1	0.9
Median of all reaction times	2.2	3.1	4.7	2.2	-1.4	1.6
Reaction time omissions	0.7	1.0	1.3	1.1	-1.1	0.7
Reaction time false alarm rate	0.9	1.2	2.1	-1.4	-0.1	-1.3
Reaction time premature initiation rate	2.4	3.2	4.7	1.9	1.2	2.2
Reaction time premature initiations	1.3	1.9	2.5	1.5	0.8	1.6
Std. dev. reaction times	0.1	0.2	0.4	0.4	-0.6	-0.2
Reaction time trials completed	0.2	0.2	0.5	-0.3	-0.4	-0.7
Reaction time trials AUC	0.1	0.1	0.3	-0.3	-0.1	-0.6
Run reversals in cocaine runway, females	1.4	1.4	1.6	-1.3	-1.2	-1.1
Run reversals in cocaine runway, males	2.7	2.6	3.9	-2.0	0.6	-1.9
Latency to leave start box in cocaine runway	0.8	0.9	2.3	-0.6	1.5	-0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-0.5	1.0	-0.0
Latency to leave start box in cocaine runway, M	0.5	0.5	1.5	-0.3	1.2	0.1
Std. dev. time between licks in bursts	0.8	0.9	1.4	1.2	-0.3	1.1
Total sessions with >9 infusions	2.9	3.2	5.8	-2.4	0.9	-1.7
Short access day 1 total inactive lever presses	0.6	0.6	1.0	-0.9	1.0	-0.2
Short access day 10 total inactive lever presses	0.6	0.7	0.8	0.8	0.9	0.8
Short access day 1 total infusions	2.4	2.6	4.5	-2.1	1.1	-1.5
Short access day 10 total infusions	1.3	1.4	2.8	-1.7	0.7	-1.0
Short access total infusions	2.0	2.2	3.2	-1.8	1.6	-0.9
Short access day 1 locomotion	0.1	0.1	0.2	-0.4	0.2	-0.2
Short access day 10 total locomotion	2.2	2.5	4.2	-2.0	-0.2	-1.8
Short access total locomotion	0.6	0.6	1.2	-1.1	0.6	-0.6
One hour access (0.3 mA shock)	0.7	0.8	1.1	-1.1	0.5	-1.0
Compulsive drug intake	1.0	1.0	1.7	1.3	-0.3	1.1
One hour access (shock baseline)	1.5	1.8	3.1	-1.8	0.4	-1.4
Social response proportion	0.3	0.3	0.7	-0.5	0.8	0.1
Social responses	1.4	1.8	2.7	-1.7	1.1	-1.2
Social time	0.9	1.2	1.6	-1.0	-1.3	-0.9
Soleus weight	0.2	0.6	1.2	0.8	0.3	1.1
Bone: stiffness	4.4	6.9	10.7	3.1	0.6	3.3
Tibialis anterior weight	0.1	0.4	0.6	0.8	-0.3	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.5	-0.4	-0.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	-0.6	-0.2	-0.4
Time to tail flick, test, before self-admin	1.6	1.6	3.1	-1.8	0.5	-1.2
Time to tail flick, test, after self-admin	1.4	1.4	1.6	1.1	-1.3	1.2
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.9	0.7	0.8	1.0
Delta time to tail flick, test, before/after SA	3.9	3.5	4.5	2.1	-1.8	1.7
Tibia length	0.0	0.0	0.0	0.2	0.1	0.2
Ambulatory time before self-admin	0.7	0.8	1.0	-1.0	0.5	-1.0
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	-0.0	0.2
Bone: tissue strength	2.3	2.3	3.6	1.9	-0.4	1.7
Total heroin consumption	1.6	1.8	2.6	1.6	0.7	1.5
Bone: trabecular number	0.6	1.0	2.2	-0.5	-1.5	-0.7
Bone: trabecular spacing	1.8	2.3	6.7	-0.3	2.6	0.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	-0.4	-0.4
Bone: trabecular tissue density	0.8	1.2	2.2	1.5	-0.4	1.1
Water consumed over 24 hours	0.7	0.8	2.1	-0.6	1.4	0.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	-0.2	0.0