LOC120093690

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120093690	0.06	0.03	2.8e-05	0.02	0.03	0.03	0.04	7.1e-03	1.4e-03	9.0e-04	1.1e-04
2	NAcc	gene expression	LOC120093690	0.03	0.02	8.7e-05	0.03	0.03	0.02	0.03	6.9e-05	1.5e-04	2.6e-03	1.6e-04
3	Adipose	gene expression	LOC120093690	0.08	0.04	3.2e-09	0.09	0.07	0.06	0.08	9.9e-10	2.7e-08	1.1e-07	6.3e-09
4	IL	gene expression	LOC120093690	0.21	0.1	1.7e-03	0.02	0.06	0.04	0.05	1.2e-01	1.3e-02	3.5e-02	2.4e-02
5	PL	gene expression	LOC120093690	0.04	0.02	6.8e-05	0.03	0.02	0.01	0.02	7.0e-04	1.1e-03	3.4e-02	3.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.1	0.2	0.4	-0.2	0.2	-0.2	-0.1
Area under the delay curve	4.4	4.7	6.4	2.3	-2.5	-2.5	2.4	-0.2
BMI with tail	0.0	0.1	0.4	-0.7	0.3	0.5	0.0	-0.1
BMI without tail	0.1	0.2	0.5	0.7	-0.4	-0.0	0.2	0.6
Body weight	1.4	6.0	8.9	-2.8	3.0	2.8	-2.2	-0.8
Weight adjusted by age	0.4	0.5	0.9	-0.3	0.9	0.9	-0.5	0.6
Bone surface	0.1	0.2	0.5	0.4	-0.3	-0.1	0.7	-0.3
Bone volume	0.0	0.0	0.1	0.2	-0.2	0.2	0.1	0.0
Breakpoint value in progressive ratio session	0.2	0.2	0.7	0.5	-0.8	-0.3	0.1	-0.1
Number of licking bursts	0.6	0.7	1.0	0.9	-1.0	-0.9	0.7	0.1
Context. condit. distance diff. score	6.7	8.0	11.6	-3.4	3.1	3.2	-2.8	0.9
Locomotion velocity, session 1	0.6	0.6	1.4	0.4	-0.3	-0.6	1.2	-1.0
Locomotion distance, session 1	4.9	6.3	9.4	2.8	-2.6	-2.7	3.1	-0.1
Locomotion velocity, session 2	0.4	0.4	2.0	-0.1	-0.3	-0.2	1.4	-0.2
Locomotion distance, session 2	6.0	8.4	10.8	3.3	-3.1	-3.2	3.2	-1.0
Locomotion velocity, session 3	2.4	2.8	4.3	-1.3	1.9	2.1	-1.3	1.6
Locomotion distance, session 3	0.9	1.0	4.4	0.6	-0.2	0.2	0.1	2.1
Stereotopy head waving bouts, day 3	0.5	0.6	1.5	-0.8	0.5	0.5	-0.3	-1.2
Stereotopy head waving duration, day 3	1.9	2.3	4.0	-2.0	1.6	1.6	-0.9	-1.3
Locomotion velocity, session 7	0.6	0.7	2.4	-1.5	0.7	0.7	-0.5	0.0
Locomotion distance, session 7	0.2	0.3	0.7	-0.3	-0.4	-0.7	-0.1	-0.8
Stereotopy head waving bouts, day 7	3.6	4.0	7.2	-2.7	2.3	2.5	-1.1	0.5
Stereotopy head waving duration, day 7	3.4	4.1	6.2	-2.5	2.3	2.5	-1.2	1.2
Locomotion velocity, session 8	1.0	1.2	3.1	-1.8	1.1	1.1	-0.2	-0.7
Locomotion distance, session 8	0.3	0.5	0.8	-0.6	0.9	0.8	-0.5	0.5
Degree of sensitization distance	1.8	1.8	5.6	-1.5	0.6	0.1	-1.0	-2.4
Degree of sensitization stereotypy	2.6	2.8	4.4	-2.0	1.9	2.1	-0.6	1.2
Conditioned locomotion	0.2	0.2	0.4	-0.7	0.5	0.6	-0.4	-0.2
Cocaine response after cond. corrected	0.5	0.5	1.8	0.1	-0.3	-0.2	0.9	-1.3
Cocaine response after cond. not corrected	0.2	0.3	0.8	0.1	-0.2	-0.0	0.7	-0.9
Cocaine response before conditioning	0.2	0.2	1.0	0.0	0.0	0.1	-0.4	1.0
Saline control response	1.0	1.3	2.1	-0.7	1.4	1.1	-1.4	0.9
Bone: connectivity density	0.1	0.1	0.2	0.0	0.3	0.4	-0.4	-0.2
Bone: cortical apparent density	0.7	0.9	3.3	0.1	0.6	0.5	-0.9	1.8
Bone: cortical area	0.2	0.2	0.7	-0.6	0.0	-0.1	0.4	-0.8
Bone: cortical porosity	0.9	1.0	3.1	-1.2	0.3	0.4	0.2	-1.7
Bone: cortical porosity	1.3	1.5	4.9	-1.4	0.3	0.3	0.4	-2.2
Bone: cortical thickness	0.4	0.7	1.5	0.6	-1.0	-1.2	0.8	-0.3
Bone: cortical thickness	1.7	2.0	3.7	1.4	-1.4	-1.9	1.4	-0.7
Bone: cortical tissue density	0.7	0.9	3.0	-0.0	0.7	0.5	-0.9	1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.5	-0.0	-0.2	-0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.1	-0.4	0.7	0.5	-1.1	0.6
Condit. Reinf. active responses	0.5	0.6	1.6	1.1	-0.1	-0.2	-1.2	0.5
Condit. Reinf. inactive responses	0.7	0.8	1.8	1.3	-0.1	-0.1	-1.3	0.9
Incentive salience index mean	0.2	0.3	0.7	0.9	-0.2	-0.4	-0.7	-0.0
Condit. Reinf. lever presses	0.2	0.3	0.8	0.9	-0.2	-0.4	-0.8	-0.1
Condit. Reinf. active minus inactive responses	1.1	1.4	1.8	0.8	-1.1	-1.3	1.2	-1.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.8	0.3	-0.5	-0.8	0.7	-1.4
Condit. Reinf. active responses	0.7	1.0	2.2	0.1	-0.8	-0.8	1.3	-1.5
Condit. Reinf. inactive responses	0.3	0.4	1.1	-0.4	-0.7	-0.4	1.0	-0.5
Condit. Reinf. lever presses	0.5	0.6	1.2	1.1	-1.0	-1.0	0.4	-0.3
Condit. Reinf. lever reinforcers received	0.7	1.0	2.5	0.2	-0.7	-0.8	1.1	-1.6
Conditioned reinforcement - actives	1.7	1.7	2.8	1.1	-1.6	-1.4	1.7	-0.5
Conditioned reinforcement - inactives	1.3	1.5	2.6	1.4	-1.6	-1.4	0.7	-0.7
Conditioned locomotion	0.9	1.1	1.8	0.6	-0.8	-1.3	1.1	-1.2
Patch foraging indifference point 0 sec	0.2	0.4	1.1	0.5	0.3	-0.2	-1.1	-0.5
Patch foraging indifference point AUC	2.1	2.4	3.9	1.3	-1.8	-2.0	1.6	-0.8
Delay disc. indifference point, 0s delay	0.1	0.2	0.6	0.0	-0.1	-0.4	0.1	-0.8
Delay disc. indifference point, 16s delay	5.7	5.8	8.0	2.6	-2.8	-2.7	2.7	-0.5
Delay disc. indifference point, 2s delay	5.7	6.3	10.8	2.3	-2.9	-2.7	3.3	-0.0
Delay disc. indifference point, 24s delay	0.9	0.8	1.5	0.7	-1.0	-0.9	1.2	-0.5
Delay disc. indifference point, 4s delay	2.9	3.1	4.4	1.9	-1.7	-2.1	2.0	-0.5
Delay disc. indifference point, 8s delay	2.8	2.9	4.4	2.0	-2.1	-2.1	1.4	-0.1
Indifference point function ln k	2.9	4.0	6.5	-2.1	2.4	2.5	-1.8	0.8
Indifference point function log k	2.9	4.0	6.5	-2.1	2.4	2.5	-1.8	0.8
Patch foraging total patch changes 0 sec	0.2	0.4	0.9	1.0	-0.0	-0.5	-0.8	-0.3
Patch foraging total patch changes 12 sec	0.8	1.1	2.0	0.6	-0.7	-1.4	0.7	-1.4
Patch foraging total patch changes 18 sec	1.3	1.7	3.4	1.0	-1.4	-1.3	0.7	-1.8
Patch foraging total patch changes 24 sec	0.6	0.7	1.8	0.8	-1.1	-1.3	0.1	-0.2
Patch foraging total patch changes 6 sec	1.0	1.5	2.8	1.2	-1.2	-1.7	0.7	-1.1
Patch foraging time to switch 0 sec	0.3	0.4	1.0	-0.3	-0.5	-0.3	1.0	-0.9
Patch foraging water rate 0 sec	0.5	0.9	3.3	0.4	0.8	0.5	-1.8	-0.0
Patch foraging water rate 12 sec	0.6	0.9	1.6	-0.0	1.0	0.7	-1.3	1.2
Patch foraging water rate 18 sec	0.4	0.5	1.4	0.4	0.8	0.5	-1.2	0.1
Patch foraging water rate 24 sec	2.4	3.3	5.4	-1.4	2.3	2.1	-2.2	0.2
Patch foraging water rate 6 sec	0.9	1.4	3.3	0.1	1.1	1.2	-1.8	1.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	0.8	-0.6	-0.5	0.6	0.6
Distance traveled before self-admin	2.7	2.9	4.3	1.4	-1.9	-2.1	2.1	-0.7
Distance traveled after self-admin	1.2	1.4	5.0	0.6	-0.9	-0.7	0.5	-2.2
Extensor digitorum longus weight	0.5	2.0	4.4	2.1	-1.4	-1.2	1.2	0.8
Bone: elastic displacement	0.2	0.3	0.4	-0.5	0.6	0.6	-0.3	-0.5
Bone: elastic work	0.9	1.2	4.7	-0.8	0.5	0.5	0.2	-2.2
Bone: endosteal estimation	0.6	1.3	2.3	-1.4	0.8	1.2	0.0	-1.5
Bone: endosteal perimeter	0.8	1.6	3.7	-1.9	1.1	1.3	-0.0	-1.0
Epididymis fat weight	2.6	6.2	11.4	-3.4	2.9	2.7	-1.9	0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	-0.2	-0.3	-0.8	0.4	-0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.5	0.7	-0.3	0.0	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	0.5	-0.6	-0.7	0.2	-0.2
Delay discount exponential model param	4.5	4.7	6.3	-2.3	2.5	2.5	-2.4	0.1
Extinction: sum of active levers before priming	2.5	2.5	4.2	1.2	-2.0	-1.6	2.0	-0.0
Active lever presses in extinction session 6	0.1	0.1	0.2	0.0	-0.4	-0.3	0.4	-0.5
Bone: final force	0.6	1.0	3.2	-0.4	-0.5	-0.3	1.1	-1.8
Bone: final moment	0.6	0.9	3.5	-0.4	-0.4	-0.2	1.0	-1.9
Food consumed during 24 hour testing period	0.5	0.6	2.0	-0.8	-0.0	0.2	0.3	-1.4
Glucose	0.3	0.5	1.5	-0.3	0.4	0.6	-1.2	-0.6
Heart weight	2.7	3.9	6.7	-2.1	2.3	1.7	-2.6	0.2
Delay discount hyperbolic model param	4.9	5.2	6.8	-2.4	2.6	2.6	-2.5	0.2
Intermittent access intake day 1-15 change	0.2	0.2	0.6	0.8	-0.3	0.0	0.0	0.3
Intermittent access intake escalation	0.2	0.2	0.6	0.8	-0.4	-0.0	0.1	0.4
Intermittent access intake escalation 2	0.1	0.1	0.3	0.6	-0.1	0.1	-0.3	0.3
Intermitt. access day 1 inactive lever presses	0.4	0.5	2.0	0.3	-0.4	-0.2	-0.1	-1.4
Intermitt. access day 15 inactive lever presses	0.3	0.3	1.1	0.1	-0.4	-0.4	0.3	-1.0
Intermitt. access escalation Index	0.3	0.2	0.3	0.0	-0.5	-0.6	0.5	0.5
Intermittent access day 1 total infusions	1.3	1.5	3.1	0.3	-1.1	-0.9	1.5	-1.8
Intermittent access day 15 total infusions	1.3	1.4	2.0	1.1	-1.2	-0.9	1.3	-1.4
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.3	0.8	-1.0	-0.6	1.2	-0.9
Intermittent access total infusions	2.1	2.4	3.7	0.8	-1.6	-1.2	1.9	-1.8
Intermittent access day 1 locomotion	0.7	0.7	1.9	0.2	-0.7	-0.8	0.7	-1.4
Intermittent access day 15 total locomotion	0.1	0.1	0.3	-0.5	-0.2	0.0	0.1	-0.5
Intermittent access total locomotion	0.6	0.7	2.9	-0.7	-0.2	-0.0	-0.0	-1.7
Intermittent access standard deviation	1.1	1.2	4.6	0.6	-0.8	-0.4	0.5	-2.1
Left kidney weight	4.6	13.1	28.5	-5.3	4.0	3.7	-2.3	-1.3
Right kidney weight	5.7	16.1	27.8	-5.3	4.5	3.8	-3.3	-2.5
Cocaine induced anxiety	0.9	1.0	2.1	-1.4	0.8	1.4	-0.7	0.2
Post-drug Anxiety	2.1	2.4	3.6	-1.5	1.7	1.9	-1.7	0.1
Baseline Anxiety	0.3	0.3	1.0	0.3	0.5	-0.0	-1.0	0.6
Tail length	0.6	1.7	3.6	-0.7	1.4	1.5	-1.9	0.4
Length with tail	2.1	7.7	11.5	-2.8	3.4	3.1	-3.0	-0.7
Length without tail	2.5	5.5	8.2	-2.9	2.8	2.4	-2.1	-1.2
Times rat made contact with spout	0.2	0.2	0.4	0.4	-0.2	-0.2	-0.6	-0.5
Lifetime Intake	2.4	2.8	5.1	0.6	-1.7	-1.3	2.0	-2.3
Liver weight, left	1.0	1.7	3.5	-1.6	1.9	1.4	-0.5	-0.0
Liver weight, right	4.2	7.0	10.3	-3.2	3.0	3.2	-2.2	1.0
Locomotor activity	1.4	2.2	3.4	-1.8	1.9	1.5	-1.2	-0.6
Locomotor testing distance	0.2	0.3	0.5	-0.3	0.7	0.4	-0.7	0.5
Locomotor testing rearing	0.4	0.7	1.7	-1.3	1.0	0.6	-0.5	-0.3
Locomotion in novel chamber	1.6	2.0	8.1	1.1	0.2	0.2	-0.9	2.8
Locomotion in novel chamber post-restriction	1.0	1.2	1.6	1.3	-1.1	-1.1	1.2	0.9
Fecal boli incidents, locomotor time 1	1.5	1.7	3.7	0.8	-1.2	-1.4	0.9	-1.9
Change in fecal boli incidents, locomotor task	1.2	1.1	1.5	-1.2	1.2	1.1	-0.6	1.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	2.0	-0.4	0.2	0.4	0.0	-1.4
Bouts of movement, locomotor time 1	0.3	0.3	1.2	-1.1	0.3	0.5	-0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.6	-0.0	-0.0	0.1	-0.5
Rest time, locomotor task time 1	0.4	0.4	1.4	-0.7	-0.5	0.0	-0.0	-1.2
Distance moved, locomotor task time 1	1.1	1.2	2.7	-0.6	1.6	0.9	-0.9	1.1
Vertical activity count, locomotor time 1	2.0	2.1	4.7	-0.9	1.8	1.3	-2.2	0.5
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.7	-0.4	0.2	0.7	-0.4	-0.8
Bouts of movement, locomotor time 2	0.4	0.4	0.8	-0.5	-0.7	-0.0	0.9	0.8
Total resting periods, locomotor time 2	0.6	0.7	1.8	-0.1	-1.1	-0.4	1.3	0.3
Rest time, locomotor task time 2	0.5	0.5	1.0	0.5	-1.0	-0.6	0.8	-0.7
Distance moved, locomotor task time 2	1.2	1.4	2.5	-1.0	1.6	1.2	-1.3	0.5
Vertical activity count, locomotor time 2	1.9	2.1	3.1	-1.5	1.5	1.6	-1.8	-0.2
Light reinforcement 1	0.0	0.1	0.1	0.4	0.1	-0.3	0.3	-0.2
Light reinforcement 2	0.4	0.6	1.0	-1.0	0.9	0.9	-0.3	0.4
Bone: marrow area	0.6	1.4	2.5	-1.4	0.9	1.2	0.0	-1.6
Bone: maximum diameter	1.0	1.8	3.6	-1.9	1.2	1.1	-0.1	-1.6
Bone: maximum force	0.8	1.4	5.0	-0.7	-0.4	-0.3	1.1	-2.2
Bone: maximum moment	0.8	1.4	5.3	-0.7	-0.4	-0.2	1.0	-2.3
Mean time between licks in bursts	0.9	1.3	2.2	1.4	-1.0	-1.2	1.5	0.2
Mean num. licks in bursts	0.8	0.9	1.6	-0.9	1.1	0.9	-1.3	-0.1
Cd content in liver	0.6	0.7	2.0	-0.1	0.8	0.8	-0.1	1.4
Co content in liver	0.1	0.1	0.3	0.5	0.2	-0.1	0.1	-0.2
Cu content in liver	2.4	2.9	6.6	2.6	-1.5	-1.7	1.1	1.3
Fe content in liver	2.1	2.5	4.9	-1.2	2.0	2.2	-1.5	-0.4
K content in liver	0.8	0.8	1.2	0.8	-1.0	-0.8	1.1	-0.6
Mg content in liver	0.5	0.5	0.6	0.7	-0.8	-0.7	0.8	-0.6
Mn content in liver	0.1	0.2	0.3	-0.1	-0.6	-0.3	0.5	0.4
Na content in liver	0.3	0.3	1.1	1.0	-0.3	-0.4	-0.0	0.3
Rb content in liver	0.2	0.3	0.4	0.5	-0.4	-0.6	0.2	-0.6
Se content in liver	1.1	1.3	5.0	0.9	0.5	0.7	-0.2	2.2
Sr content in liver	2.0	1.8	3.6	1.9	-1.3	-1.1	0.6	1.4
Zn content in liver	0.5	0.5	1.4	1.2	-0.5	-0.5	0.8	0.4
Bone: minimum diameter	0.3	0.5	1.6	-1.0	0.2	0.3	0.2	-1.3
Time in familiar zone, hab. session 1	0.5	0.4	1.1	0.4	-0.6	-0.6	1.1	-0.2
Time in novel zone, hab. session 1	1.4	1.3	2.0	-1.1	1.4	1.4	-1.2	-0.1
Total zone transitions, hab. session 1	1.5	2.1	4.5	2.1	-0.9	-1.0	0.8	1.9
Total locomotion distance, hab. session 1	0.5	0.7	2.8	0.8	0.2	-0.0	-0.2	1.7
Locomotion velocity, hab. session 1	0.6	0.9	2.2	1.3	-0.3	-0.5	0.1	1.5
Time in familiar zone, hab. session 2	0.7	0.8	3.0	-0.3	0.4	0.6	-0.3	1.7
Time in novel zone, hab. session 2	0.7	0.7	2.9	0.2	-0.4	-0.5	0.1	-1.7
Total zone transitions, hab. session 2	2.0	2.6	4.4	2.1	-1.7	-1.7	1.4	-0.8
Total locomotion distance, hab. session 2	1.7	2.3	3.0	1.7	-1.6	-1.7	1.4	-1.2
Locomotion velocity, hab. session 2	2.1	2.9	4.3	2.1	-1.8	-1.9	1.4	-1.2
Novel to familiar place preference ratio	2.5	2.6	4.9	-1.3	2.2	1.9	-1.5	0.6
Novelty place preference	3.5	3.6	6.4	-1.6	2.5	2.3	-1.7	0.8
Time in novel zone, NPP test	4.1	4.3	7.4	-1.7	2.7	2.5	-1.9	0.9
Total zone transitions, NPP test	2.2	3.2	7.1	2.7	-1.5	-1.8	1.5	1.0
Total locomotion distance, NPP test	1.1	1.5	3.1	1.8	-1.0	-1.5	1.1	0.1
Locomotion velocity, NPP test	1.6	2.2	4.0	2.0	-1.3	-1.8	1.4	0.3
Intraocular pressure	0.3	0.5	1.5	-1.2	0.4	0.6	0.1	-0.6
Delta distance traveled before/after self-admin	2.3	2.5	3.3	-1.4	1.6	1.8	-1.8	-1.3
Delta ambulatory time before/after self-admin	1.7	1.9	2.9	-0.9	1.3	1.4	-1.4	-1.7
Parametrial fat weight	0.8	1.5	3.0	-1.1	1.2	0.9	-1.7	1.1
Pavlov. Cond. lever latency	0.2	0.2	0.7	-0.8	0.4	0.5	-0.1	-0.2
Pavlov. Cond. magazine entry latency	2.2	2.9	3.6	1.7	-1.9	-1.7	1.9	-1.2
Pavlov. Cond. change in total contacts	3.3	3.6	4.7	1.9	-2.2	-2.1	1.9	-1.2
Pavlov. Cond. index score	0.9	1.2	1.3	1.0	-1.1	-1.1	1.0	-1.1
Pavlov. Cond. latency score	0.5	0.7	0.8	0.8	-0.8	-0.8	0.7	-0.9
Pavlov. Cond. lever contacts	0.6	0.7	1.1	1.1	-0.9	-1.0	0.5	-0.5
Pavlov. Cond. magazine entry number	1.4	1.8	2.4	-1.3	1.5	1.4	-1.5	0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.0	1.0	0.1	-0.3	-0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.4	1.1	-1.2	-1.2	1.1	-0.8
Pavlov. Cond. response bias	1.7	2.0	2.6	1.4	-1.6	-1.6	1.4	-1.1
Pavlov. Cond. lever latency	0.2	0.2	0.6	-0.8	-0.0	0.1	0.6	0.2
Pavlov. Cond. magazine entry latency	1.9	2.2	5.2	2.3	-1.6	-1.4	0.6	-0.9
Pavlov. Cond. change in total contacts	0.7	0.9	4.2	0.5	-0.2	-0.2	-0.0	-2.0
Pavlov. Cond. index score	0.7	0.9	2.6	1.6	-0.8	-0.8	-0.0	-0.7
Pavlov. Cond. latency score	0.9	1.1	3.2	1.8	-1.0	-1.0	-0.0	-0.8
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.8	0.1	-0.1	-0.7	-0.0
Pavlov. Cond. magazine entry number	0.5	0.6	1.9	-1.4	0.7	0.6	0.0	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.5	-1.2	-0.0	-0.1	-0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.4	1.6	-0.7	-0.7	-0.0	-0.5
Pavlov. Cond. response bias	0.4	0.6	1.4	1.2	-0.7	-0.7	0.1	-0.6
Time in closed arm before self-admin	1.3	1.5	3.2	1.8	-1.4	-1.4	0.4	-0.7
Time in closed arm after self-admin	0.3	0.3	0.8	-0.5	0.4	-0.1	-0.9	-0.6
Time in open arm before self-admin	0.6	0.7	0.8	-0.9	0.8	0.8	-0.7	0.8
Time in open arm after self-admin	0.4	0.4	1.4	0.0	0.2	0.7	-0.5	1.2
Bone: periosteal estimation	0.5	1.0	2.3	-1.3	0.6	0.7	0.3	-1.5
Bone: periosteal perimeter	1.1	1.9	4.3	-2.1	1.2	1.2	-0.2	-1.4
Bone: post-yield work	0.9	1.2	2.5	0.7	-1.0	-1.2	1.6	-0.8
Progressive ratio test 1 active lever presses	2.1	2.2	2.7	0.7	-1.5	-1.6	1.6	-1.7
Progressive ratio test 1 breakpoint	1.2	1.3	1.7	0.6	-1.2	-1.3	1.2	-1.2
Progressive ratio test 1 inactive lever presses	1.8	2.0	3.1	1.1	-1.8	-1.5	1.5	-1.0
Progressive ratio test 2 active lever presses	0.9	1.0	2.2	0.1	-1.5	-0.9	1.0	-0.9
Progressive ratio test 2 breakpoint	1.1	1.2	2.3	0.2	-1.5	-0.9	1.2	-1.2
Progressive ratio test 2 inactive lever presses	2.1	2.5	5.0	1.2	-2.2	-1.5	1.7	-0.7
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.5	-0.3	0.3	-0.2	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.6	-0.3	0.4	-0.2	0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.7	-0.7	-0.3	0.4	-0.6
Progressive ratio	0.2	0.2	0.5	0.7	-0.3	-0.5	0.2	-0.6
Food seeking constrained by brief footshock	0.1	0.2	0.6	0.0	-0.2	-0.3	0.8	-0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.6	-0.0
Retroperitoneal fat weight	3.8	12.3	23.7	-4.9	4.1	3.5	-2.9	-0.2
Reaction time number correct	0.5	0.7	3.4	0.1	-0.0	0.4	0.3	1.8
Reaction time mean minus median	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.2	-0.2
Reaction time mean minus median AUC	0.3	0.4	0.7	-0.8	0.6	0.7	-0.9	-0.1
Reaction time num false alarms	0.2	0.2	0.5	-0.1	0.7	0.2	-0.7	0.0
Reaction time num false alarms AUC	0.1	0.2	0.4	0.1	0.6	0.1	-0.6	0.2
Reaction time trials correct on left	0.5	0.7	3.4	0.1	-0.0	0.4	0.3	1.8
Reaction time trials on left	0.5	0.8	3.5	0.2	-0.1	0.4	0.4	1.9
Reaction time mean	0.1	0.1	0.3	-0.3	0.3	0.5	-0.5	-0.0
Reaction time mean AUC	0.1	0.1	0.2	-0.2	0.2	0.4	-0.4	0.1
Median of all reaction times	0.0	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0
Reaction time omissions	1.5	2.0	4.5	1.1	-1.7	-1.2	2.1	-0.2
Reaction time false alarm rate	0.2	0.2	0.5	-0.0	0.6	-0.1	-0.7	-0.4
Reaction time premature initiation rate	0.4	0.6	2.7	-0.0	-0.4	-0.1	-0.0	-1.6
Reaction time premature initiations	0.1	0.1	0.5	-0.2	-0.3	0.2	-0.1	-0.7
Std. dev. reaction times	0.5	0.7	1.1	-1.0	0.6	1.1	-0.9	-0.4
Reaction time trials completed	0.5	0.8	3.5	0.2	-0.1	0.4	0.4	1.9
Reaction time trials AUC	0.4	0.6	2.8	-0.1	0.0	0.5	0.2	1.7
Run reversals in cocaine runway, females	1.4	1.3	2.9	-0.7	1.0	1.0	-1.0	1.7
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.5	0.2	-0.4	0.2	-0.4
Latency to leave start box in cocaine runway	0.4	0.4	0.8	-0.9	0.5	0.8	0.4	0.4
Latency to leave start box in cocaine runway, F	0.5	0.6	2.0	0.7	-0.3	-0.5	1.4	0.3
Latency to leave start box in cocaine runway, M	2.2	2.1	4.8	-2.2	1.0	2.0	-0.8	0.2
Std. dev. time between licks in bursts	0.5	0.6	1.3	1.1	-0.5	-0.8	0.4	-0.9
Total sessions with >9 infusions	0.6	0.7	2.6	-0.5	-0.4	-0.5	0.5	-1.6
Short access day 1 total inactive lever presses	2.0	2.2	5.9	1.2	-0.9	-1.4	1.0	-2.4
Short access day 10 total inactive lever presses	1.4	1.5	3.0	-0.9	1.3	1.3	-1.7	-0.8
Short access day 1 total infusions	0.6	0.7	2.6	-0.1	-0.6	-0.3	0.5	-1.6
Short access day 10 total infusions	1.5	1.6	4.5	0.1	-0.9	-0.9	1.4	-2.1
Short access total infusions	1.7	2.0	6.2	-0.2	-1.0	-0.9	1.3	-2.5
Short access day 1 locomotion	1.0	1.1	2.2	0.6	-1.0	-1.0	0.8	-1.5
Short access day 10 total locomotion	0.7	0.8	1.8	0.6	-1.1	-0.8	-0.2	-1.4
Short access total locomotion	1.0	1.0	4.2	0.0	-0.5	-0.9	0.1	-2.0
One hour access (0.3 mA shock)	4.0	4.7	7.8	1.9	-2.8	-2.2	2.5	-0.7
Compulsive drug intake	0.4	0.4	0.7	0.7	-0.8	-0.3	-0.3	0.9
One hour access (shock baseline)	0.8	0.9	1.9	0.6	-1.1	-0.9	1.4	-0.7
Social response proportion	0.6	0.7	1.4	0.8	-0.4	-0.5	1.2	-1.0
Social responses	1.2	1.6	2.5	1.2	-1.1	-1.6	1.5	-0.8
Social time	3.3	4.4	6.9	2.6	-2.2	-2.5	1.8	-0.9
Soleus weight	0.3	0.9	1.3	0.9	-1.1	-1.0	-0.3	-1.1
Bone: stiffness	0.6	0.9	3.7	-0.7	-0.0	0.1	0.3	-1.9
Tibialis anterior weight	2.0	6.7	11.0	3.3	-3.0	-3.1	2.1	0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	0.2	0.4	-0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.3	0.2	0.8	0.5	-1.1	0.8
Time to tail flick, test, before self-admin	0.7	0.7	1.5	0.6	-0.7	-1.2	0.8	0.6
Time to tail flick, test, after self-admin	0.5	0.5	1.3	0.9	-0.2	-0.5	-0.0	1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.8	0.9	-0.3	-0.4	0.0	-0.1
Delta time to tail flick, test, before/after SA	0.8	0.7	2.2	0.6	0.5	0.5	-0.8	1.5
Tibia length	0.1	0.4	0.9	-0.8	0.4	0.3	0.4	-0.9
Ambulatory time before self-admin	1.8	1.8	2.9	1.3	-1.6	-1.7	1.4	-0.1
Ambulatory time after self-admin	0.9	1.0	2.5	1.2	-0.8	-0.6	0.4	-1.6
Bone: tissue strength	0.3	0.3	0.6	-0.6	0.4	0.8	-0.3	-0.4
Total heroin consumption	0.6	0.7	1.4	0.6	-0.9	-1.0	1.2	-0.2
Bone: trabecular number	0.3	0.5	1.0	-0.6	0.7	1.0	-0.6	0.6
Bone: trabecular spacing	0.6	0.8	2.3	-0.3	-0.4	-0.9	0.9	-1.5
Bone: trabecular thickness	0.4	0.5	1.1	-0.2	0.1	0.7	-1.0	0.8
Bone: trabecular tissue density	0.4	0.6	1.3	1.1	0.4	0.0	-1.0	0.5
Water consumed over 24 hours	0.2	0.2	0.8	0.2	-0.1	-0.1	-0.3	-0.9
Number of responses in last shaping day	5.8	6.1	8.7	2.1	-2.8	-2.5	2.9	-1.6