LOC120093556

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC120093556 0.05 0.03 5.7e-04 0.01 0.03 0.01 0.02 1.4e-02 1.4e-03 6.6e-02 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.10.10.10.3
Area under the delay curve0.50.50.5-0.7
BMI with tail1.03.43.4-1.8
BMI without tail2.96.06.0-2.4
Body weight8.535.535.5-6.0
Weight adjusted by age1.21.31.3-1.2
Bone surface0.10.10.1-0.4
Bone volume0.10.10.1-0.3
Breakpoint value in progressive ratio session0.50.60.60.8
Number of licking bursts0.00.00.00.0
Context. condit. distance diff. score1.72.12.1-1.4
Locomotion velocity, session 10.20.20.20.4
Locomotion distance, session 10.30.30.3-0.6
Locomotion velocity, session 20.50.60.60.7
Locomotion distance, session 20.40.50.5-0.7
Locomotion velocity, session 30.10.10.1-0.3
Locomotion distance, session 31.21.31.3-1.1
Stereotopy head waving bouts, day 31.51.81.81.3
Stereotopy head waving duration, day 30.91.01.01.0
Locomotion velocity, session 70.40.50.5-0.7
Locomotion distance, session 70.20.30.3-0.5
Stereotopy head waving bouts, day 70.60.60.60.8
Stereotopy head waving duration, day 70.70.90.90.9
Locomotion velocity, session 80.80.90.9-1.0
Locomotion distance, session 86.08.88.8-3.0
Degree of sensitization distance0.40.40.40.6
Degree of sensitization stereotypy1.11.21.21.1
Conditioned locomotion0.00.00.00.2
Cocaine response after cond. corrected0.00.00.00.1
Cocaine response after cond. not corrected0.10.10.1-0.4
Cocaine response before conditioning0.80.90.9-1.0
Saline control response0.00.10.10.2
Bone: connectivity density0.60.90.91.0
Bone: cortical apparent density1.11.41.4-1.2
Bone: cortical area1.52.32.3-1.5
Bone: cortical porosity0.70.80.80.9
Bone: cortical porosity0.10.10.10.4
Bone: cortical thickness0.30.50.5-0.7
Bone: cortical thickness1.21.41.41.2
Bone: cortical tissue density1.11.51.5-1.2
Condit. Reinf. active minus inactive responses0.10.20.20.4
Condit. Reinf. active-inactive response ratio0.40.40.40.7
Condit. Reinf. active responses1.62.02.01.4
Condit. Reinf. inactive responses2.52.92.91.7
Incentive salience index mean0.00.00.0-0.2
Condit. Reinf. lever presses0.40.60.6-0.8
Condit. Reinf. active minus inactive responses0.10.10.10.3
Condit. Reinf. active-inactive response ratio0.00.00.00.2
Condit. Reinf. active responses0.00.00.00.2
Condit. Reinf. inactive responses0.00.00.00.2
Condit. Reinf. lever presses0.20.20.20.5
Condit. Reinf. lever reinforcers received0.00.00.0-0.1
Conditioned reinforcement - actives0.40.40.4-0.7
Conditioned reinforcement - inactives0.10.10.1-0.3
Conditioned locomotion1.11.31.3-1.1
Patch foraging indifference point 0 sec0.20.30.30.5
Patch foraging indifference point AUC0.20.20.20.5
Delay disc. indifference point, 0s delay0.00.00.00.1
Delay disc. indifference point, 16s delay0.60.60.6-0.8
Delay disc. indifference point, 2s delay2.12.42.4-1.5
Delay disc. indifference point, 24s delay3.63.53.5-1.9
Delay disc. indifference point, 4s delay0.00.00.00.2
Delay disc. indifference point, 8s delay0.00.00.00.2
Indifference point function ln k0.40.50.5-0.7
Indifference point function log k0.40.50.5-0.7
Patch foraging total patch changes 0 sec0.30.40.40.7
Patch foraging total patch changes 12 sec0.00.00.00.1
Patch foraging total patch changes 18 sec0.10.10.10.3
Patch foraging total patch changes 24 sec0.00.00.0-0.1
Patch foraging total patch changes 6 sec0.40.60.60.8
Patch foraging time to switch 0 sec0.20.30.30.6
Patch foraging water rate 0 sec3.25.25.2-2.3
Patch foraging water rate 12 sec0.91.41.4-1.2
Patch foraging water rate 18 sec0.00.00.0-0.0
Patch foraging water rate 24 sec8.812.312.3-3.5
Patch foraging water rate 6 sec7.210.510.5-3.2
Seeking ratio, delayed vs. immediate footshock0.20.30.30.5
Distance traveled before self-admin0.91.01.0-1.0
Distance traveled after self-admin0.80.90.9-1.0
Extensor digitorum longus weight0.00.10.10.3
Bone: elastic displacement2.93.33.31.8
Bone: elastic work1.72.32.31.5
Bone: endosteal estimation0.00.00.0-0.0
Bone: endosteal perimeter2.55.25.2-2.3
Epididymis fat weight3.06.96.9-2.6
Delta time in closed arm before/after self-admin0.00.00.0-0.2
Delta time in open arm before/after self-admin2.12.02.01.4
Diff in mean of infusions in LGA sessions2.22.42.41.6
Delay discount exponential model param0.60.60.60.8
Extinction: sum of active levers before priming0.10.10.10.3
Active lever presses in extinction session 60.00.00.0-0.1
Bone: final force0.10.10.1-0.3
Bone: final moment0.10.10.1-0.3
Food consumed during 24 hour testing period0.10.20.2-0.4
Glucose0.00.10.10.2
Heart weight0.00.00.0-0.0
Delay discount hyperbolic model param0.60.70.70.8
Intermittent access intake day 1-15 change0.00.00.0-0.1
Intermittent access intake escalation0.00.00.0-0.0
Intermittent access intake escalation 20.00.00.00.1
Intermitt. access day 1 inactive lever presses5.15.55.52.3
Intermitt. access day 15 inactive lever presses0.20.20.20.5
Intermitt. access escalation Index0.50.40.40.7
Intermittent access day 1 total infusions3.74.34.3-2.1
Intermittent access day 15 total infusions3.23.53.5-1.9
Intermittent access terminal intake (last 3 days)4.65.05.0-2.2
Intermittent access total infusions4.75.35.3-2.3
Intermittent access day 1 locomotion1.01.11.1-1.0
Intermittent access day 15 total locomotion2.22.32.3-1.5
Intermittent access total locomotion1.92.22.2-1.5
Intermittent access standard deviation1.51.61.6-1.3
Left kidney weight2.98.08.0-2.8
Right kidney weight1.23.53.5-1.9
Cocaine induced anxiety0.60.70.70.9
Post-drug Anxiety0.70.70.70.9
Baseline Anxiety0.00.00.0-0.2
Tail length6.920.820.8-4.6
Length with tail11.441.641.6-6.4
Length without tail5.912.912.9-3.6
Times rat made contact with spout1.51.71.7-1.3
Lifetime Intake5.46.26.2-2.5
Liver weight, left1.32.02.0-1.4
Liver weight, right0.71.21.2-1.1
Locomotor activity4.47.07.0-2.6
Locomotor testing distance2.94.84.8-2.2
Locomotor testing rearing0.91.31.3-1.2
Locomotion in novel chamber1.21.51.5-1.2
Locomotion in novel chamber post-restriction0.00.00.0-0.1
Fecal boli incidents, locomotor time 10.00.00.00.1
Change in fecal boli incidents, locomotor task0.00.00.00.1
Time >=10cm from walls, locomotor time 10.50.60.60.7
Bouts of movement, locomotor time 10.80.80.80.9
Total resting periods, locomotor time 10.70.70.70.9
Rest time, locomotor task time 12.12.32.31.5
Distance moved, locomotor task time 11.11.21.2-1.1
Vertical activity count, locomotor time 14.95.25.2-2.3
Time >=10cm from walls, locomotor time 20.10.10.10.4
Bouts of movement, locomotor time 20.20.20.2-0.5
Total resting periods, locomotor time 20.10.10.1-0.4
Rest time, locomotor task time 20.80.90.90.9
Distance moved, locomotor task time 20.10.10.1-0.3
Vertical activity count, locomotor time 21.61.81.8-1.3
Light reinforcement 10.61.01.0-1.0
Light reinforcement 21.31.71.71.3
Bone: marrow area0.00.00.0-0.1
Bone: maximum diameter2.54.64.6-2.1
Bone: maximum force0.00.00.0-0.2
Bone: maximum moment0.00.00.0-0.2
Mean time between licks in bursts1.21.71.7-1.3
Mean num. licks in bursts0.10.20.2-0.4
Cd content in liver0.20.20.2-0.5
Co content in liver2.93.43.4-1.8
Cu content in liver0.10.10.10.3
Fe content in liver0.50.50.5-0.7
K content in liver2.22.22.21.5
Mg content in liver1.41.51.51.2
Mn content in liver0.20.30.30.5
Na content in liver0.10.10.10.3
Rb content in liver2.32.92.91.7
Se content in liver0.10.10.1-0.4
Sr content in liver0.00.00.0-0.0
Zn content in liver0.00.00.0-0.2
Bone: minimum diameter4.89.09.0-3.0
Time in familiar zone, hab. session 10.00.00.00.1
Time in novel zone, hab. session 10.80.80.80.9
Total zone transitions, hab. session 15.27.37.3-2.7
Total locomotion distance, hab. session 15.68.08.0-2.8
Locomotion velocity, hab. session 18.211.611.6-3.4
Time in familiar zone, hab. session 20.00.00.00.2
Time in novel zone, hab. session 20.10.10.10.3
Total zone transitions, hab. session 22.22.82.8-1.7
Total locomotion distance, hab. session 22.02.72.7-1.6
Locomotion velocity, hab. session 22.73.63.6-1.9
Novel to familiar place preference ratio0.10.10.1-0.4
Novelty place preference0.00.00.0-0.1
Time in novel zone, NPP test0.00.00.0-0.1
Total zone transitions, NPP test1.92.62.6-1.6
Total locomotion distance, NPP test2.12.82.8-1.7
Locomotion velocity, NPP test1.62.32.3-1.5
Intraocular pressure0.40.50.50.7
Delta distance traveled before/after self-admin0.10.10.10.2
Delta ambulatory time before/after self-admin0.70.70.70.9
Parametrial fat weight0.10.10.10.4
Pavlov. Cond. lever latency0.50.70.7-0.8
Pavlov. Cond. magazine entry latency0.10.20.2-0.4
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.00.00.00.2
Pavlov. Cond. latency score0.10.10.10.3
Pavlov. Cond. lever contacts0.00.00.00.1
Pavlov. Cond. magazine entry number0.10.20.20.4
Pavlov. Cond. intertrial magazine entries0.00.00.00.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.0
Pavlov. Cond. response bias0.00.00.0-0.2
Pavlov. Cond. lever latency0.10.10.10.4
Pavlov. Cond. magazine entry latency1.21.41.4-1.2
Pavlov. Cond. change in total contacts4.36.06.0-2.4
Pavlov. Cond. index score1.92.52.5-1.6
Pavlov. Cond. latency score1.41.81.8-1.3
Pavlov. Cond. lever contacts0.20.30.3-0.5
Pavlov. Cond. magazine entry number2.63.23.21.8
Pavlov. Cond. intertrial magazine entries0.20.20.20.5
Pavlov. Cond. lever-magazine prob. diff.2.22.82.8-1.7
Pavlov. Cond. response bias0.91.21.2-1.1
Time in closed arm before self-admin0.91.01.0-1.0
Time in closed arm after self-admin0.20.20.2-0.5
Time in open arm before self-admin0.00.00.0-0.1
Time in open arm after self-admin0.50.60.60.8
Bone: periosteal estimation0.71.41.4-1.2
Bone: periosteal perimeter1.72.92.9-1.7
Bone: post-yield work0.00.00.00.1
Progressive ratio test 1 active lever presses5.25.45.4-2.3
Progressive ratio test 1 breakpoint5.35.55.5-2.3
Progressive ratio test 1 inactive lever presses0.10.10.1-0.3
Progressive ratio test 2 active lever presses3.23.43.4-1.8
Progressive ratio test 2 breakpoint3.53.93.9-2.0
Progressive ratio test 2 inactive lever presses0.20.30.3-0.5
Incentive Sensitization - Responses1.51.51.5-1.2
Incentive Sensitization - Breakpoint1.11.11.1-1.1
Sum of active levers in priming session hrs 5-60.10.10.1-0.2
Progressive ratio0.00.00.00.1
Food seeking constrained by brief footshock0.10.10.1-0.3
Seeking ratio, punishment vs. effort0.00.00.00.0
Retroperitoneal fat weight4.314.214.2-3.8
Reaction time number correct0.10.10.1-0.3
Reaction time mean minus median0.50.70.70.8
Reaction time mean minus median AUC0.70.90.91.0
Reaction time num false alarms2.73.63.61.9
Reaction time num false alarms AUC3.14.34.32.1
Reaction time trials correct on left0.10.10.1-0.3
Reaction time trials on left0.00.10.1-0.2
Reaction time mean0.00.10.1-0.2
Reaction time mean AUC0.00.10.1-0.2
Median of all reaction times0.30.40.4-0.6
Reaction time omissions1.82.52.51.6
Reaction time false alarm rate2.83.93.92.0
Reaction time premature initiation rate0.50.60.6-0.8
Reaction time premature initiations0.60.80.8-0.9
Std. dev. reaction times0.60.80.80.9
Reaction time trials completed0.00.10.1-0.2
Reaction time trials AUC0.00.10.1-0.3
Run reversals in cocaine runway, females1.31.31.3-1.1
Run reversals in cocaine runway, males0.10.10.10.3
Latency to leave start box in cocaine runway0.50.50.5-0.7
Latency to leave start box in cocaine runway, F0.00.00.00.2
Latency to leave start box in cocaine runway, M1.71.71.7-1.3
Std. dev. time between licks in bursts0.20.30.3-0.5
Total sessions with >9 infusions3.03.33.3-1.8
Short access day 1 total inactive lever presses0.10.10.10.3
Short access day 10 total inactive lever presses2.02.22.21.5
Short access day 1 total infusions3.73.93.9-2.0
Short access day 10 total infusions5.05.65.6-2.4
Short access total infusions6.27.07.0-2.6
Short access day 1 locomotion1.81.91.9-1.4
Short access day 10 total locomotion0.10.10.10.4
Short access total locomotion0.50.50.5-0.7
One hour access (0.3 mA shock)6.07.07.0-2.6
Compulsive drug intake0.10.10.10.3
One hour access (shock baseline)4.65.35.3-2.3
Social response proportion0.91.01.0-1.0
Social responses2.33.03.0-1.7
Social time0.10.10.10.4
Soleus weight0.00.00.0-0.1
Bone: stiffness0.40.60.6-0.8
Tibialis anterior weight0.31.21.21.1
Time to tail flick, vehicle, before self-admin4.64.84.8-2.2
Time to tail flick, vehicle, after self-admin3.74.04.02.0
Time to tail flick, test, before self-admin0.00.00.00.1
Time to tail flick, test, after self-admin0.10.10.1-0.2
Delta time to tail flick, vehicle, before/after SA8.58.48.42.9
Delta time to tail flick, test, before/after SA0.00.00.0-0.1
Tibia length12.334.734.7-5.9
Ambulatory time before self-admin0.50.50.5-0.7
Ambulatory time after self-admin1.71.81.8-1.3
Bone: tissue strength0.10.10.10.4
Total heroin consumption0.10.10.1-0.4
Bone: trabecular number0.50.80.80.9
Bone: trabecular spacing0.30.30.3-0.6
Bone: trabecular thickness0.00.00.00.1
Bone: trabecular tissue density0.10.10.1-0.3
Water consumed over 24 hours0.00.00.00.1
Number of responses in last shaping day0.50.50.5-0.7