Hub : Genes

LOC120093529

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120093529	0.04	0.03	7.4e-03	0.01	0.02	0.01	0.01	1.9e-02	6.3e-03	9.0e-02	2.1e-02
2	NAcc	gene expression	LOC120093529	0.04	0.03	3.4e-06	0.04	0.04	0.03	0.04	9.0e-07	9.6e-07	6.5e-06	1.1e-06
3	PL	gene expression	LOC120093529	0.03	0.02	7.6e-04	0.01	0.02	0.02	0.02	1.3e-02	1.0e-03	1.5e-03	3.2e-03
4	pVTA	gene expression	LOC120093529	0.08	0.05	1.8e-07	0.08	0.08	0.07	0.08	3.7e-07	3.4e-07	1.2e-06	4.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.6	1.2	2.3	-0.1	-0.5	1.5	1.5
Area under the delay curve	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.1
BMI with tail	7.2	25.1	32.7	-5.7	5.4	-4.4	-4.4
BMI without tail	1.2	6.4	7.7	-2.8	2.8	-2.2	-2.2
Body weight	1.5	6.6	8.2	-2.6	2.9	-2.4	-2.4
Weight adjusted by age	0.0	0.0	0.0	0.2	0.0	-0.0	-0.0
Bone surface	2.4	4.7	7.8	0.7	-1.6	2.8	2.8
Bone volume	1.9	3.8	6.6	0.4	-1.4	2.6	2.6
Breakpoint value in progressive ratio session	0.5	0.8	1.5	1.2	-1.0	0.7	0.7
Number of licking bursts	1.5	4.7	5.1	-2.1	2.3	-2.1	-2.1
Context. condit. distance diff. score	0.2	0.3	0.4	-0.6	0.5	-0.5	-0.5
Locomotion velocity, session 1	0.3	0.3	0.5	-0.5	-0.1	0.7	0.7
Locomotion distance, session 1	1.1	1.4	2.1	0.4	-1.0	1.5	1.5
Locomotion velocity, session 2	3.2	3.8	5.0	1.3	-1.9	2.2	2.2
Locomotion distance, session 2	3.8	5.3	6.6	1.8	-2.2	2.6	2.6
Locomotion velocity, session 3	3.7	4.3	5.9	2.4	-2.2	1.8	1.8
Locomotion distance, session 3	0.0	0.0	0.1	0.3	-0.2	0.0	0.0
Stereotopy head waving bouts, day 3	5.9	7.0	8.2	2.9	-2.7	2.5	2.5
Stereotopy head waving duration, day 3	4.4	5.5	6.6	2.6	-2.5	2.2	2.1
Locomotion velocity, session 7	0.2	0.2	0.3	0.2	-0.5	0.6	0.6
Locomotion distance, session 7	0.3	0.4	0.6	-0.3	0.4	-0.8	-0.8
Stereotopy head waving bouts, day 7	1.6	1.8	2.5	0.9	-1.3	1.6	1.6
Stereotopy head waving duration, day 7	1.7	2.1	3.0	0.8	-1.3	1.7	1.7
Locomotion velocity, session 8	2.4	2.9	4.2	1.0	-1.5	2.0	2.0
Locomotion distance, session 8	0.4	0.6	0.8	0.6	-0.8	0.9	0.9
Degree of sensitization distance	0.4	0.5	0.8	-0.9	0.7	-0.6	-0.6
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.4	-0.0	0.4	0.4
Conditioned locomotion	2.0	2.3	3.1	-1.1	1.4	-1.7	-1.7
Cocaine response after cond. corrected	2.5	3.7	4.3	-1.6	1.9	-2.1	-2.1
Cocaine response after cond. not corrected	2.8	4.1	4.9	-1.6	2.0	-2.2	-2.2
Cocaine response before conditioning	0.5	0.6	0.7	0.9	-0.8	0.7	0.7
Saline control response	1.0	1.3	1.6	-0.9	1.3	-1.2	-1.2
Bone: connectivity density	0.4	0.7	1.3	0.1	-0.4	1.1	1.1
Bone: cortical apparent density	0.6	1.0	1.5	-1.2	0.9	-0.8	-0.8
Bone: cortical area	0.2	0.3	0.6	-0.8	0.1	0.5	0.5
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.3	0.5	0.5
Bone: cortical porosity	0.2	0.2	0.4	-0.1	-0.2	0.6	0.6
Bone: cortical thickness	0.4	0.7	2.0	-1.4	0.8	-0.4	-0.4
Bone: cortical thickness	1.0	1.2	1.4	-1.0	1.0	-1.2	-1.2
Bone: cortical tissue density	0.4	0.7	1.1	-1.0	0.7	-0.7	-0.7
Condit. Reinf. active minus inactive responses	2.0	2.3	2.7	1.7	-1.7	1.4	1.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.7	-0.5	0.1	0.1
Condit. Reinf. active responses	3.6	4.6	5.0	2.0	-2.2	2.1	2.1
Condit. Reinf. inactive responses	2.3	2.9	3.6	1.3	-1.7	1.9	1.9
Incentive salience index mean	1.8	2.3	2.5	1.3	-1.6	1.6	1.6
Condit. Reinf. lever presses	1.0	1.4	2.4	0.4	-1.0	1.5	1.5
Condit. Reinf. active minus inactive responses	1.1	1.7	3.6	1.9	-1.4	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	0.8	-0.3	-0.5	-0.6
Condit. Reinf. active responses	1.6	2.3	3.4	1.8	-1.6	1.2	1.2
Condit. Reinf. inactive responses	0.7	1.0	1.3	0.9	-0.9	1.1	1.1
Condit. Reinf. lever presses	1.6	2.4	4.5	2.1	-1.7	1.1	1.1
Condit. Reinf. lever reinforcers received	1.0	1.4	2.6	1.6	-1.3	0.9	0.8
Conditioned reinforcement - actives	0.0	0.1	0.2	0.4	-0.5	0.2	0.2
Conditioned reinforcement - inactives	0.1	0.4	0.7	-0.1	0.3	-0.8	-0.8
Conditioned locomotion	3.3	4.9	6.5	2.3	-2.5	2.0	1.9
Patch foraging indifference point 0 sec	1.3	3.6	5.7	-2.4	2.1	-1.5	-1.5
Patch foraging indifference point AUC	0.2	0.5	0.9	0.9	-0.8	0.6	0.6
Delay disc. indifference point, 0s delay	0.7	0.8	2.4	-1.5	0.9	0.1	0.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.3	0.3	-0.5	0.4	0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.8	0.5	-0.0	0.0
Delay disc. indifference point, 24s delay	0.3	0.4	0.7	-0.9	0.7	-0.5	-0.5
Delay disc. indifference point, 4s delay	0.6	0.6	1.0	0.4	-0.6	1.0	1.0
Delay disc. indifference point, 8s delay	0.3	0.6	0.7	-0.6	0.8	-0.8	-0.8
Indifference point function ln k	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.2
Indifference point function log k	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.2
Patch foraging total patch changes 0 sec	1.1	3.2	5.0	-2.2	2.0	-1.4	-1.4
Patch foraging total patch changes 12 sec	2.0	2.6	3.3	-1.6	1.8	-1.5	-1.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.3	0.3	-0.0	-0.0
Patch foraging total patch changes 24 sec	0.1	0.4	0.8	-0.9	0.7	-0.3	-0.3
Patch foraging total patch changes 6 sec	0.9	1.4	2.5	-1.6	1.3	-0.9	-0.9
Patch foraging time to switch 0 sec	0.0	0.1	0.4	-0.6	0.3	0.2	0.2
Patch foraging water rate 0 sec	0.4	1.5	1.9	-0.8	1.2	-1.4	-1.4
Patch foraging water rate 12 sec	0.4	1.8	2.4	-1.0	1.2	-1.5	-1.5
Patch foraging water rate 18 sec	0.7	1.6	2.7	-0.0	0.9	-1.6	-1.7
Patch foraging water rate 24 sec	4.3	6.1	8.5	-1.4	2.3	-2.9	-2.9
Patch foraging water rate 6 sec	0.3	0.4	0.8	0.9	-0.2	-0.6	-0.7
Seeking ratio, delayed vs. immediate footshock	1.8	2.6	3.0	1.6	-1.7	1.6	1.5
Distance traveled before self-admin	0.6	1.4	1.9	1.4	-1.2	1.0	1.0
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.0
Extensor digitorum longus weight	5.6	22.3	24.6	-4.8	5.0	-4.6	-4.5
Bone: elastic displacement	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0
Bone: elastic work	0.4	0.5	1.2	-1.1	0.8	-0.3	-0.3
Bone: endosteal estimation	0.1	0.2	0.7	-0.8	0.5	-0.1	-0.1
Bone: endosteal perimeter	0.7	1.8	2.3	1.0	-1.2	1.5	1.5
Epididymis fat weight	0.0	0.2	0.3	0.3	0.1	-0.6	-0.6
Delta time in closed arm before/after self-admin	3.2	3.0	4.4	-0.9	1.6	-2.1	-2.1
Delta time in open arm before/after self-admin	1.1	1.2	1.7	-1.3	1.2	-1.0	-0.9
Diff in mean of infusions in LGA sessions	1.1	1.9	3.0	1.7	-1.5	1.1	1.1
Delay discount exponential model param	0.0	0.0	0.1	0.3	-0.3	0.1	0.1
Extinction: sum of active levers before priming	0.5	0.7	1.9	1.4	-0.9	0.4	0.4
Active lever presses in extinction session 6	0.3	0.3	0.3	0.5	-0.6	0.6	0.6
Bone: final force	0.9	1.5	4.0	-2.0	1.2	-0.4	-0.4
Bone: final moment	0.9	1.4	4.0	-2.0	1.2	-0.4	-0.4
Food consumed during 24 hour testing period	0.2	0.4	0.6	-0.7	0.7	-0.5	-0.5
Glucose	1.6	2.5	3.2	-1.8	1.7	-1.4	-1.4
Heart weight	0.1	0.2	0.5	0.7	-0.4	0.0	0.0
Delay discount hyperbolic model param	0.1	0.2	0.4	0.6	-0.5	0.1	0.1
Intermittent access intake day 1-15 change	0.1	0.5	1.4	1.2	-0.7	0.2	0.2
Intermittent access intake escalation	0.1	0.4	1.2	1.1	-0.6	0.1	0.1
Intermittent access intake escalation 2	0.3	0.5	1.3	1.1	-0.8	0.4	0.4
Intermitt. access day 1 inactive lever presses	0.0	0.3	0.6	0.8	-0.0	-0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.2	1.1	-0.7	0.5	0.5
Intermitt. access escalation Index	0.1	0.2	0.4	-0.1	-0.2	0.6	0.6
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.3	0.2	-0.3	-0.3
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	-0.5	0.3	0.2
Intermittent access terminal intake (last 3 days)	0.3	0.5	0.7	0.6	-0.8	0.7	0.7
Intermittent access total infusions	0.0	0.0	0.1	0.1	-0.2	0.1	0.1
Intermittent access day 1 locomotion	0.1	0.2	0.3	-0.1	0.3	-0.6	-0.6
Intermittent access day 15 total locomotion	0.1	0.4	1.0	1.0	-0.8	0.1	0.1
Intermittent access total locomotion	0.1	0.1	0.4	0.6	-0.5	0.1	0.1
Intermittent access standard deviation	0.4	2.2	2.8	1.5	-1.7	1.4	1.3
Left kidney weight	0.0	0.1	0.1	-0.2	0.3	-0.3	-0.3
Right kidney weight	0.0	0.2	0.4	0.6	-0.4	0.1	0.2
Cocaine induced anxiety	1.1	3.1	3.6	1.4	-1.7	1.9	1.9
Post-drug Anxiety	2.2	2.5	3.4	1.0	-1.5	1.8	1.8
Baseline Anxiety	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Tail length	1.8	9.7	15.1	3.9	-3.3	2.6	2.5
Length with tail	0.8	3.4	6.8	2.6	-1.9	1.3	1.3
Length without tail	0.2	1.1	1.3	-0.9	1.1	-1.1	-1.1
Times rat made contact with spout	1.7	1.9	2.3	-1.3	1.5	-1.4	-1.4
Lifetime Intake	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1
Liver weight, left	0.4	0.8	1.0	-1.0	0.9	-0.8	-0.8
Liver weight, right	0.0	0.0	0.0	0.2	0.1	-0.2	-0.2
Locomotor activity	3.4	5.3	5.9	2.2	-2.4	2.3	2.3
Locomotor testing distance	1.2	3.0	3.4	1.7	-1.9	1.7	1.7
Locomotor testing rearing	0.0	0.0	0.1	0.0	0.2	-0.2	-0.2
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.1
Locomotion in novel chamber post-restriction	1.5	4.5	6.1	2.5	-2.3	1.8	1.8
Fecal boli incidents, locomotor time 1	0.7	1.9	2.0	-1.1	1.4	-1.4	-1.4
Change in fecal boli incidents, locomotor task	1.6	1.6	2.2	0.8	-1.2	1.5	1.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	-0.7	0.3	0.3	0.3
Bouts of movement, locomotor time 1	0.4	0.6	0.9	1.0	-0.8	0.6	0.5
Total resting periods, locomotor time 1	1.1	1.3	1.8	1.4	-1.2	0.9	0.9
Rest time, locomotor task time 1	0.5	0.8	0.9	0.7	-0.8	0.9	0.9
Distance moved, locomotor task time 1	0.1	0.2	0.6	-0.8	0.2	0.3	0.3
Vertical activity count, locomotor time 1	0.1	0.9	1.1	-1.1	0.9	-0.9	-0.9
Time >=10cm from walls, locomotor time 2	0.5	1.4	1.5	-1.1	1.2	-1.2	-1.2
Bouts of movement, locomotor time 2	0.2	0.7	1.2	0.4	-0.7	1.1	1.1
Total resting periods, locomotor time 2	0.2	0.9	1.4	0.4	-0.7	1.2	1.2
Rest time, locomotor task time 2	0.2	0.4	0.6	0.2	-0.5	0.8	0.8
Distance moved, locomotor task time 2	0.1	0.2	0.4	-0.1	0.3	-0.6	-0.6
Vertical activity count, locomotor time 2	0.9	2.2	2.8	-1.1	1.4	-1.6	-1.7
Light reinforcement 1	1.5	6.8	8.3	2.9	-2.8	2.4	2.3
Light reinforcement 2	0.6	1.4	2.0	1.4	-1.2	1.1	1.0
Bone: marrow area	0.1	0.2	0.6	-0.7	0.4	-0.0	-0.0
Bone: maximum diameter	1.3	2.6	3.4	1.1	-1.6	1.8	1.8
Bone: maximum force	0.9	1.8	4.5	-2.1	1.4	-0.6	-0.6
Bone: maximum moment	1.0	1.8	4.5	-2.1	1.4	-0.7	-0.6
Mean time between licks in bursts	0.2	1.0	1.6	1.3	-1.2	0.8	0.8
Mean num. licks in bursts	0.3	0.8	0.9	0.9	-0.9	0.9	0.9
Cd content in liver	0.6	0.6	0.9	0.8	-1.0	0.7	0.7
Co content in liver	1.7	2.1	3.7	1.9	-1.6	1.0	1.0
Cu content in liver	0.1	0.2	0.3	-0.4	-0.2	0.5	0.5
Fe content in liver	0.2	0.2	0.3	-0.4	0.3	-0.6	-0.6
K content in liver	1.5	1.5	1.7	1.0	-1.2	1.3	1.3
Mg content in liver	1.4	1.6	1.7	1.2	-1.2	1.3	1.3
Mn content in liver	4.2	4.7	6.3	1.4	-2.1	2.5	2.5
Na content in liver	0.1	0.1	0.2	-0.4	0.1	0.2	0.2
Rb content in liver	0.3	0.3	0.6	-0.2	-0.3	0.8	0.8
Se content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	0.1
Sr content in liver	0.2	0.2	0.3	0.6	-0.5	-0.1	-0.1
Zn content in liver	1.0	1.2	3.5	1.9	-1.1	0.2	0.2
Bone: minimum diameter	0.1	0.2	0.4	-0.3	-0.2	0.6	0.6
Time in familiar zone, hab. session 1	2.4	2.7	4.8	2.2	-1.7	1.2	1.2
Time in novel zone, hab. session 1	1.1	1.3	3.3	-1.8	1.2	-0.4	-0.4
Total zone transitions, hab. session 1	1.0	1.4	2.2	0.6	-0.9	1.5	1.5
Total locomotion distance, hab. session 1	3.5	5.0	6.9	1.5	-2.0	2.6	2.6
Locomotion velocity, hab. session 1	3.1	4.4	5.7	1.6	-1.9	2.4	2.4
Time in familiar zone, hab. session 2	2.6	3.0	6.0	2.5	-1.9	1.1	1.1
Time in novel zone, hab. session 2	2.6	2.8	6.1	-2.5	1.9	-0.9	-0.9
Total zone transitions, hab. session 2	0.3	0.4	0.6	-0.8	0.0	0.7	0.7
Total locomotion distance, hab. session 2	0.8	1.0	1.6	0.5	-0.8	1.3	1.3
Locomotion velocity, hab. session 2	1.1	1.5	2.3	0.5	-1.0	1.5	1.5
Novel to familiar place preference ratio	0.9	1.2	3.2	-1.8	1.2	-0.3	-0.3
Novelty place preference	0.5	0.7	1.9	-1.4	0.9	-0.1	-0.1
Time in novel zone, NPP test	0.8	1.0	2.6	-1.6	1.1	-0.4	-0.3
Total zone transitions, NPP test	0.2	0.3	0.8	-0.9	0.6	0.1	0.1
Total locomotion distance, NPP test	0.2	0.3	0.5	-0.3	-0.0	0.7	0.7
Locomotion velocity, NPP test	0.3	0.4	0.8	0.0	-0.3	0.9	0.9
Intraocular pressure	0.3	0.4	0.7	0.3	0.5	-0.8	-0.8
Delta distance traveled before/after self-admin	0.7	0.7	0.9	-0.9	1.0	-0.8	-0.7
Delta ambulatory time before/after self-admin	0.2	0.4	0.9	-1.0	0.7	-0.4	-0.4
Parametrial fat weight	0.2	0.5	0.9	-1.0	0.9	-0.5	-0.5
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.2	0.7	-1.2	-1.2
Pavlov. Cond. magazine entry latency	1.2	1.6	2.1	1.4	-1.4	1.1	1.1
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2
Pavlov. Cond. index score	0.7	0.9	1.1	0.7	-1.0	1.0	1.1
Pavlov. Cond. latency score	1.1	1.4	1.8	0.8	-1.1	1.3	1.3
Pavlov. Cond. lever contacts	0.4	0.4	0.8	-0.1	-0.4	0.9	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.9	0.8	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.2	0.0	-0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.1	0.8	-1.0	1.1	1.1
Pavlov. Cond. response bias	0.4	0.5	0.6	0.8	-0.8	0.6	0.6
Pavlov. Cond. lever latency	1.2	1.7	2.5	-1.6	1.3	-1.2	-1.1
Pavlov. Cond. magazine entry latency	1.7	2.3	3.2	1.8	-1.5	1.4	1.4
Pavlov. Cond. change in total contacts	0.3	0.8	1.4	1.2	-0.9	0.7	0.7
Pavlov. Cond. index score	1.3	2.1	3.2	1.8	-1.5	1.2	1.2
Pavlov. Cond. latency score	1.5	2.4	3.3	1.8	-1.6	1.4	1.4
Pavlov. Cond. lever contacts	0.9	1.4	2.3	1.5	-1.2	0.9	0.9
Pavlov. Cond. magazine entry number	2.1	2.8	3.5	-1.9	1.7	-1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.7	1.6	1.9	-1.2	1.4	-1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.7	3.7	1.9	-1.7	1.4	1.4
Pavlov. Cond. response bias	1.6	2.1	3.8	1.9	-1.5	1.1	1.1
Time in closed arm before self-admin	0.1	0.2	0.3	-0.2	-0.2	0.5	0.5
Time in closed arm after self-admin	0.2	0.2	0.3	-0.3	0.3	-0.5	-0.6
Time in open arm before self-admin	0.0	0.1	0.1	0.4	-0.3	0.1	0.1
Time in open arm after self-admin	2.2	2.5	3.0	-1.6	1.7	-1.5	-1.5
Bone: periosteal estimation	0.1	0.3	0.9	-1.0	0.2	0.4	0.4
Bone: periosteal perimeter	0.5	1.0	1.6	0.3	-0.8	1.3	1.3
Bone: post-yield work	0.3	0.4	0.7	-0.8	0.8	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	-0.5	0.4	-0.4	-0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.2	-0.5	0.4	-0.5	-0.5
Progressive ratio test 1 inactive lever presses	0.2	0.5	0.7	0.8	-0.8	0.5	0.5
Progressive ratio test 2 active lever presses	0.1	0.2	0.2	0.5	-0.5	0.3	0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.3	0.6	-0.6	0.4	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.1	-0.3	0.4	0.4
Incentive Sensitization - Responses	0.1	0.3	0.5	0.7	-0.5	0.4	0.4
Incentive Sensitization - Breakpoint	0.2	0.5	0.7	0.8	-0.7	0.6	0.6
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	-0.2	0.1	0.1
Progressive ratio	0.5	1.5	1.6	-1.1	1.2	-1.3	-1.3
Food seeking constrained by brief footshock	0.8	1.0	1.5	1.2	-1.0	0.8	0.8
Seeking ratio, punishment vs. effort	0.9	2.1	2.7	1.6	-1.5	1.3	1.3
Retroperitoneal fat weight	2.5	11.3	12.6	-3.1	3.5	-3.4	-3.4
Reaction time number correct	0.7	2.4	2.7	-1.3	1.6	-1.6	-1.6
Reaction time mean minus median	0.2	1.5	1.8	1.3	-1.3	1.2	1.2
Reaction time mean minus median AUC	0.5	3.4	4.2	1.3	-1.8	2.0	2.1
Reaction time num false alarms	0.6	0.9	1.4	-0.9	1.2	-0.9	-0.9
Reaction time num false alarms AUC	0.5	1.2	1.7	-1.0	1.3	-1.1	-1.1
Reaction time trials correct on left	0.7	2.4	2.7	-1.3	1.6	-1.6	-1.6
Reaction time trials on left	0.7	2.2	2.5	-1.2	1.6	-1.6	-1.6
Reaction time mean	1.1	2.4	2.8	1.2	-1.6	1.7	1.7
Reaction time mean AUC	0.6	1.4	1.8	0.8	-1.2	1.3	1.4
Median of all reaction times	1.0	1.6	2.0	0.9	-1.3	1.4	1.4
Reaction time omissions	0.2	0.3	0.5	0.2	-0.6	0.7	0.7
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.1
Reaction time premature initiation rate	0.4	0.6	1.6	1.3	-0.8	0.3	0.3
Reaction time premature initiations	0.1	0.3	0.4	0.6	0.0	-0.6	-0.7
Std. dev. reaction times	0.5	1.6	1.8	1.1	-1.2	1.3	1.3
Reaction time trials completed	0.7	2.2	2.5	-1.2	1.6	-1.6	-1.6
Reaction time trials AUC	0.8	2.8	3.2	-1.3	1.8	-1.8	-1.8
Run reversals in cocaine runway, females	3.0	3.4	3.6	1.7	-1.9	1.9	1.9
Run reversals in cocaine runway, males	3.0	3.3	4.1	1.7	-2.0	1.8	1.8
Latency to leave start box in cocaine runway	0.3	0.4	0.7	-0.3	-0.1	0.8	0.9
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	-0.4	-0.2	1.1	1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.0	0.3	-0.3	-0.3
Std. dev. time between licks in bursts	1.1	2.1	2.6	1.1	-1.4	1.6	1.6
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0
Short access day 1 total inactive lever presses	0.1	0.2	0.7	0.8	-0.4	0.2	0.1
Short access day 10 total inactive lever presses	0.1	0.4	0.6	0.5	0.2	-0.8	-0.8
Short access day 1 total infusions	0.0	0.0	0.1	-0.0	-0.2	0.0	0.0
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1
Short access total infusions	0.0	0.0	0.1	-0.4	0.1	-0.1	-0.1
Short access day 1 locomotion	0.5	0.8	1.4	1.2	-1.1	0.6	0.6
Short access day 10 total locomotion	0.4	1.5	4.0	2.0	-1.3	0.5	0.4
Short access total locomotion	0.3	0.5	1.1	1.1	-0.9	0.4	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.2	0.4	-0.5	-0.6
Compulsive drug intake	0.0	0.0	0.0	0.1	-0.2	0.2	0.2
One hour access (shock baseline)	0.0	0.1	0.2	0.4	-0.3	0.1	0.1
Social response proportion	0.7	0.9	1.1	0.8	-1.0	1.0	1.0
Social responses	8.5	11.2	12.1	3.4	-3.5	3.2	3.2
Social time	1.3	2.0	2.2	-1.5	1.4	-1.4	-1.4
Soleus weight	5.3	15.7	20.9	-4.6	4.3	-3.4	-3.4
Bone: stiffness	1.6	2.8	6.0	-2.4	1.8	-1.1	-1.1
Tibialis anterior weight	1.2	4.2	5.6	-2.4	2.2	-1.8	-1.8
Time to tail flick, vehicle, before self-admin	1.5	1.8	2.2	1.2	-1.5	1.4	1.4
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.2	0.5	0.3	-0.5	-0.5
Time to tail flick, test, before self-admin	1.5	1.8	2.4	0.9	-1.2	1.5	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	-0.2	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	2.9	3.1	3.8	-1.4	1.9	-1.9	-1.9
Delta time to tail flick, test, before/after SA	0.5	0.7	1.1	-0.2	0.7	-1.0	-1.0
Tibia length	0.5	1.3	2.3	1.5	-1.2	0.9	0.9
Ambulatory time before self-admin	0.1	0.3	0.6	0.8	-0.6	0.5	0.5
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.0
Bone: tissue strength	2.9	3.1	5.4	-2.3	1.9	-1.3	-1.3
Total heroin consumption	2.0	2.4	2.6	1.6	-1.5	1.5	1.5
Bone: trabecular number	0.9	1.7	2.5	0.8	-1.0	1.6	1.6
Bone: trabecular spacing	1.4	2.1	3.5	-0.4	1.0	-1.9	-1.9
Bone: trabecular thickness	1.8	2.4	4.5	-0.1	-0.9	2.1	2.1
Bone: trabecular tissue density	3.9	6.8	7.7	-2.7	2.8	-2.5	-2.5
Water consumed over 24 hours	0.2	0.3	0.8	-0.9	0.6	-0.0	-0.0
Number of responses in last shaping day	1.8	2.3	4.2	2.1	-1.7	1.0	1.0