Hub : Genes

LOC108352740

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative polyA XR_001841118.2 0.09 0.06 1.1e-04 0.03 0.04 0.03 0.02 7.8e-04 2.0e-04 2.1e-03 4.1e-03
2 Brain alternative polyA XR_005493220.1 0.09 0.07 8.7e-05 0.03 0.04 0.03 0.02 4.9e-04 1.9e-04 2.1e-03 3.5e-03
3 Adipose alternative polyA XR_001841118.2 0.02 0.01 3.4e-03 0.01 0.01 0 0.01 8.4e-03 9.3e-03 7.3e-02 2.5e-02
4 Adipose alternative polyA XR_005493220.1 0.02 0.01 3.9e-03 0.01 0.01 0 0.01 7.1e-03 1.1e-02 8.8e-02 3.0e-02
5 PL alternative polyA XR_001841118.2 0.02 0.02 5.7e-03 0.01 0 0.01 0.01 8.6e-03 2.7e-01 5.0e-02 1.8e-02
6 PL alternative TSS XR_005493220.1 0.06 0.04 5.9e-03 0.01 0.01 0.01 0.01 1.7e-02 6.2e-02 2.4e-02 2.3e-02
7 Brain gene expression LOC108352740 0.11 0.05 2.2e-13 0.14 0.12 0.14 0.12 5.3e-13 1.1e-11 1.1e-12 1.1e-11
8 Adipose gene expression LOC108352740 0.05 0.03 1.6e-07 0.06 0.05 0.06 0.05 4.2e-07 2.6e-06 8.1e-07 5.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.50.83.5-1.11.10.4-0.40.41.9-0.2-0.2
Area under the delay curve0.40.40.7-0.80.80.5-0.50.7-0.3-0.7-0.7
BMI with tail0.10.20.80.2-0.2-0.30.3-0.30.90.70.6
BMI without tail0.20.52.30.1-0.1-0.60.6-0.41.50.70.6
Body weight0.20.84.30.2-0.3-0.40.4-0.52.11.00.8
Weight adjusted by age0.70.81.60.3-0.3-1.31.3-1.3-0.51.00.4
Bone surface0.20.31.5-0.60.6-0.20.20.01.20.10.0
Bone volume0.20.31.6-0.30.3-0.30.3-0.21.30.40.3
Breakpoint value in progressive ratio session0.70.81.5-0.90.90.8-0.80.60.2-1.2-1.2
Number of licking bursts0.20.20.5-0.20.2-0.50.5-0.50.70.30.4
Context. condit. distance diff. score3.74.56.62.0-2.0-2.62.6-2.4-0.42.12.2
Locomotion velocity, session 10.40.51.00.5-0.5-1.01.0-0.7-0.50.60.5
Locomotion distance, session 10.60.81.50.9-0.9-1.21.2-0.9-0.60.40.4
Locomotion velocity, session 20.30.40.7-0.40.40.7-0.70.7-0.6-0.8-0.7
Locomotion distance, session 21.41.93.3-1.21.21.3-1.31.4-0.7-1.8-1.8
Locomotion velocity, session 31.21.52.31.2-1.3-1.51.5-1.30.51.01.1
Locomotion distance, session 31.81.92.71.6-1.6-1.51.5-1.5-0.31.21.2
Stereotopy head waving bouts, day 31.21.43.8-0.60.71.2-1.21.3-2.0-1.0-1.1
Stereotopy head waving duration, day 32.63.116.01.8-1.8-0.70.7-0.5-4.00.80.8
Locomotion velocity, session 72.83.04.31.6-1.6-2.02.0-1.9-0.21.92.1
Locomotion distance, session 74.35.58.52.9-2.9-2.12.1-2.1-2.02.12.2
Stereotopy head waving bouts, day 71.92.19.21.5-1.5-0.80.8-0.7-3.00.80.8
Stereotopy head waving duration, day 73.74.56.0-2.52.52.1-2.12.20.5-2.2-2.3
Locomotion velocity, session 80.30.40.7-0.90.90.4-0.40.50.3-0.7-0.6
Locomotion distance, session 81.42.02.91.5-1.5-1.71.7-1.6-1.01.01.1
Degree of sensitization distance1.41.42.21.5-1.5-0.80.8-0.9-1.11.31.4
Degree of sensitization stereotypy1.61.82.7-1.61.61.2-1.21.30.9-1.3-1.4
Conditioned locomotion0.60.71.2-0.70.71.0-1.00.8-1.1-0.7-0.7
Cocaine response after cond. corrected0.70.81.2-0.90.90.9-0.90.8-1.1-0.8-0.7
Cocaine response after cond. not corrected0.20.20.8-0.50.50.3-0.30.2-0.9-0.4-0.3
Cocaine response before conditioning0.40.51.10.4-0.4-1.11.1-0.80.20.60.4
Saline control response0.30.40.80.3-0.3-0.60.6-0.70.90.60.5
Bone: connectivity density2.74.26.0-2.42.42.1-2.12.11.4-1.8-1.9
Bone: cortical apparent density1.11.48.5-1.11.10.3-0.30.42.9-0.4-0.3
Bone: cortical area1.21.82.90.6-0.7-1.51.5-1.41.71.41.4
Bone: cortical porosity1.11.22.0-1.41.40.8-0.81.2-0.4-1.2-1.2
Bone: cortical porosity1.01.12.1-1.51.40.7-0.71.10.0-1.1-1.1
Bone: cortical thickness1.62.64.10.9-1.0-1.81.8-1.62.01.81.7
Bone: cortical thickness0.00.00.1-0.40.4-0.10.10.1-0.1-0.2-0.1
Bone: cortical tissue density1.01.37.9-1.11.00.4-0.40.42.8-0.4-0.3
Condit. Reinf. active minus inactive responses0.30.31.5-0.10.10.4-0.40.6-1.2-0.7-0.4
Condit. Reinf. active-inactive response ratio0.10.10.40.2-0.1-0.20.2-0.0-0.70.00.3
Condit. Reinf. active responses0.91.11.9-0.60.60.9-0.91.2-1.4-1.4-1.1
Condit. Reinf. inactive responses0.40.50.8-0.40.40.8-0.80.9-0.1-0.9-0.9
Incentive salience index mean0.70.91.8-1.01.00.7-0.70.9-0.5-1.3-1.1
Condit. Reinf. lever presses1.62.23.5-1.91.91.1-1.11.30.7-1.8-1.7
Condit. Reinf. active minus inactive responses0.10.10.20.1-0.1-0.40.4-0.3-0.10.30.2
Condit. Reinf. active-inactive response ratio0.00.00.1-0.30.30.0-0.00.0-0.1-0.1-0.1
Condit. Reinf. active responses0.60.91.60.8-0.8-1.31.3-1.10.30.90.8
Condit. Reinf. inactive responses1.92.33.11.6-1.6-1.71.7-1.60.51.41.4
Condit. Reinf. lever presses0.30.40.6-0.80.80.3-0.30.50.2-0.8-0.7
Condit. Reinf. lever reinforcers received0.30.40.80.5-0.5-0.90.9-0.70.40.50.4
Conditioned reinforcement - actives0.10.10.10.3-0.3-0.20.2-0.10.30.20.3
Conditioned reinforcement - inactives1.41.52.7-0.91.00.8-0.81.1-1.6-1.6-1.6
Conditioned locomotion1.01.22.90.3-0.4-1.71.7-1.70.50.20.3
Patch foraging indifference point 0 sec2.94.76.62.6-2.6-2.32.3-2.10.12.32.2
Patch foraging indifference point AUC1.92.23.11.7-1.7-1.71.7-1.7-0.31.11.4
Delay disc. indifference point, 0s delay0.20.31.0-0.50.50.1-0.10.2-1.0-0.6-0.6
Delay disc. indifference point, 16s delay1.21.22.0-1.41.41.1-1.11.00.7-1.1-1.0
Delay disc. indifference point, 2s delay0.00.00.1-0.20.2-0.00.00.1-0.3-0.0-0.0
Delay disc. indifference point, 24s delay0.60.61.8-0.80.70.6-0.60.71.3-0.6-0.6
Delay disc. indifference point, 4s delay0.60.61.2-1.11.10.0-0.00.2-1.0-0.8-0.7
Delay disc. indifference point, 8s delay0.20.20.3-0.40.40.4-0.40.5-0.4-0.5-0.4
Indifference point function ln k1.01.31.9-1.11.11.2-1.21.4-0.8-1.0-1.3
Indifference point function log k1.01.31.9-1.11.11.2-1.21.4-0.8-1.0-1.3
Patch foraging total patch changes 0 sec4.57.210.03.2-3.2-2.72.7-2.50.22.92.8
Patch foraging total patch changes 12 sec1.72.22.61.6-1.6-1.51.5-1.40.81.61.6
Patch foraging total patch changes 18 sec5.06.47.72.7-2.7-2.82.8-2.6-0.32.62.7
Patch foraging total patch changes 24 sec4.25.16.92.4-2.4-2.62.6-2.30.62.12.3
Patch foraging total patch changes 6 sec3.45.17.52.3-2.3-2.72.7-2.60.52.02.0
Patch foraging time to switch 0 sec1.32.14.1-1.81.81.2-1.21.02.0-1.0-1.0
Patch foraging water rate 0 sec0.50.74.20.8-0.8-0.30.3-0.1-2.10.30.4
Patch foraging water rate 12 sec0.60.96.70.2-0.1-0.10.10.1-2.6-0.2-0.1
Patch foraging water rate 18 sec1.21.62.7-1.11.11.3-1.31.2-0.7-1.5-1.6
Patch foraging water rate 24 sec0.40.50.7-0.50.50.8-0.80.7-0.8-0.8-0.8
Patch foraging water rate 6 sec0.60.84.9-0.20.20.7-0.70.5-2.2-0.7-0.5
Seeking ratio, delayed vs. immediate footshock1.82.13.1-1.31.31.5-1.51.5-1.0-1.6-1.8
Distance traveled before self-admin0.80.81.8-0.10.1-1.11.1-1.41.30.60.6
Distance traveled after self-admin0.10.10.40.0-0.00.0-0.0-0.20.60.60.5
Extensor digitorum longus weight1.56.011.1-3.33.32.1-2.12.02.0-2.2-2.2
Bone: elastic displacement0.10.10.60.2-0.1-0.30.3-0.3-0.80.10.1
Bone: elastic work0.10.10.30.0-0.0-0.50.5-0.50.10.30.2
Bone: endosteal estimation0.10.30.50.1-0.1-0.70.7-0.70.60.60.6
Bone: endosteal perimeter0.00.10.20.1-0.1-0.20.2-0.2-0.40.30.3
Epididymis fat weight1.02.33.71.9-1.9-1.51.5-1.40.41.71.5
Delta time in closed arm before/after self-admin0.90.91.31.0-1.0-1.11.1-0.90.50.60.9
Delta time in open arm before/after self-admin0.20.10.4-0.10.10.6-0.60.50.30.20.0
Diff in mean of infusions in LGA sessions0.70.81.7-0.80.90.8-0.80.8-0.3-1.3-1.0
Delay discount exponential model param0.20.20.40.7-0.7-0.30.3-0.40.10.50.4
Extinction: sum of active levers before priming0.20.20.60.6-0.5-0.10.1-0.2-0.8-0.3-0.1
Active lever presses in extinction session 60.10.10.40.7-0.7-0.00.0-0.1-0.10.40.3
Bone: final force0.40.61.9-1.21.2-0.10.10.11.40.1-0.1
Bone: final moment0.50.72.1-1.41.40.2-0.20.41.2-0.2-0.4
Food consumed during 24 hour testing period0.10.10.40.5-0.40.3-0.30.3-0.60.10.0
Glucose0.10.10.2-0.40.50.3-0.30.3-0.1-0.1-0.3
Heart weight0.10.20.4-0.20.20.3-0.30.6-0.7-0.4-0.4
Delay discount hyperbolic model param0.20.20.50.7-0.7-0.30.3-0.50.20.60.5
Intermittent access intake day 1-15 change2.42.44.4-1.31.32.1-2.12.10.5-1.1-1.3
Intermittent access intake escalation2.02.04.1-1.01.01.9-1.92.00.4-0.9-1.0
Intermittent access intake escalation 23.53.46.7-1.61.62.4-2.42.6-0.4-1.4-1.5
Intermitt. access day 1 inactive lever presses4.65.07.92.8-2.8-2.12.1-1.7-0.82.42.4
Intermitt. access day 15 inactive lever presses0.50.61.7-0.40.40.7-0.70.6-0.7-1.0-1.3
Intermitt. access escalation Index0.20.20.50.2-0.2-0.50.5-0.5-0.70.30.2
Intermittent access day 1 total infusions0.60.73.2-0.20.20.4-0.40.5-1.8-0.9-0.8
Intermittent access day 15 total infusions3.03.35.1-1.31.32.2-2.22.3-1.5-1.7-1.8
Intermittent access terminal intake (last 3 days)5.45.98.4-1.81.82.8-2.82.9-2.3-2.3-2.5
Intermittent access total infusions1.71.92.7-1.01.01.5-1.51.6-1.3-1.4-1.5
Intermittent access day 1 locomotion0.50.61.90.6-0.6-0.80.8-0.7-1.40.00.2
Intermittent access day 15 total locomotion1.11.11.6-0.50.61.2-1.21.2-1.0-1.3-1.3
Intermittent access total locomotion0.10.10.50.1-0.1-0.30.3-0.2-0.7-0.3-0.4
Intermittent access standard deviation0.50.51.1-0.20.21.1-1.11.00.7-0.0-0.1
Left kidney weight0.82.312.70.2-0.3-0.90.9-1.03.61.31.1
Right kidney weight0.71.93.01.1-1.1-1.41.4-1.51.71.31.4
Cocaine induced anxiety0.50.61.1-1.01.00.5-0.50.7-0.1-0.9-0.9
Post-drug Anxiety0.10.10.70.0-0.10.1-0.10.20.80.10.4
Baseline Anxiety0.10.10.20.2-0.20.4-0.40.20.5-0.00.1
Tail length0.31.03.20.5-0.5-1.01.0-0.81.80.80.9
Length with tail0.20.82.60.6-0.7-0.80.8-0.81.60.90.8
Length without tail0.30.71.00.7-0.8-0.80.8-1.00.90.90.8
Times rat made contact with spout0.10.10.2-0.10.1-0.40.4-0.4-0.00.20.2
Lifetime Intake1.41.62.6-0.90.91.5-1.51.6-0.7-1.3-1.3
Liver weight, left0.20.40.60.6-0.6-0.50.5-0.70.30.60.7
Liver weight, right0.20.42.7-0.20.20.2-0.20.21.7-0.2-0.2
Locomotor activity4.57.210.43.2-3.2-2.62.6-2.5-1.92.62.6
Locomotor testing distance4.16.89.53.1-3.1-2.52.5-2.3-1.72.72.7
Locomotor testing rearing2.53.85.52.3-2.3-1.91.9-1.9-0.02.12.0
Locomotion in novel chamber1.82.22.8-1.21.21.7-1.71.6-1.5-1.5-1.3
Locomotion in novel chamber post-restriction0.40.51.20.2-0.2-0.80.8-0.91.10.50.4
Fecal boli incidents, locomotor time 14.14.55.42.3-2.3-2.32.3-2.3-0.82.12.0
Change in fecal boli incidents, locomotor task1.71.62.0-1.41.41.3-1.31.3-0.1-1.4-1.1
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.1-0.10.1-0.10.3-0.00.2
Bouts of movement, locomotor time 10.00.00.0-0.00.1-0.10.1-0.1-0.20.20.2
Total resting periods, locomotor time 10.10.10.30.1-0.0-0.10.1-0.10.30.50.4
Rest time, locomotor task time 11.11.21.41.2-1.1-1.01.0-1.0-1.21.11.0
Distance moved, locomotor task time 11.71.92.5-1.41.41.6-1.61.60.1-1.3-1.3
Vertical activity count, locomotor time 14.34.55.4-2.32.32.3-2.32.3-0.4-2.3-2.2
Time >=10cm from walls, locomotor time 22.12.22.7-1.51.51.6-1.61.6-0.3-1.6-1.6
Bouts of movement, locomotor time 20.50.50.70.9-0.8-0.70.7-0.7-0.80.50.5
Total resting periods, locomotor time 21.01.11.51.2-1.2-1.01.0-1.0-1.10.80.8
Rest time, locomotor task time 24.14.75.52.4-2.3-2.02.0-2.0-2.32.12.1
Distance moved, locomotor task time 26.37.39.2-2.72.73.0-3.03.01.5-2.6-2.7
Vertical activity count, locomotor time 28.18.911.3-3.13.13.2-3.23.20.2-3.3-3.4
Light reinforcement 10.20.40.70.3-0.3-0.80.8-0.80.20.50.6
Light reinforcement 20.81.12.01.0-1.0-1.11.1-0.9-1.40.71.0
Bone: marrow area0.10.20.4-0.00.0-0.60.6-0.60.50.50.5
Bone: maximum diameter0.50.91.20.8-0.8-1.11.1-1.00.41.01.0
Bone: maximum force0.40.72.0-0.20.2-0.80.8-0.71.40.90.8
Bone: maximum moment0.20.41.5-0.50.5-0.50.5-0.41.20.60.4
Mean time between licks in bursts2.13.03.91.9-1.9-2.02.0-1.9-0.51.61.5
Mean num. licks in bursts0.20.21.50.2-0.20.2-0.20.3-1.2-0.2-0.3
Cd content in liver0.10.10.30.4-0.4-0.10.10.0-0.50.10.1
Co content in liver2.12.44.0-2.02.01.4-1.41.50.1-1.6-1.6
Cu content in liver0.00.00.10.3-0.3-0.20.2-0.1-0.20.00.1
Fe content in liver0.91.13.9-0.30.40.9-0.91.0-2.0-1.0-0.9
K content in liver4.14.15.01.7-1.7-2.22.2-2.11.72.22.2
Mg content in liver2.62.63.21.8-1.7-1.81.8-1.6-0.11.71.7
Mn content in liver5.56.28.0-2.82.82.7-2.72.71.1-2.4-2.4
Na content in liver0.70.81.1-0.80.81.0-1.01.1-0.2-0.9-0.9
Rb content in liver0.10.10.5-0.50.50.2-0.20.20.7-0.2-0.2
Se content in liver1.31.62.4-1.01.01.5-1.51.5-0.7-1.4-1.4
Sr content in liver0.20.21.4-0.20.2-0.20.2-0.21.20.20.2
Zn content in liver0.10.11.0-0.00.10.0-0.00.2-1.0-0.3-0.3
Bone: minimum diameter0.91.72.30.9-0.9-1.51.5-1.41.11.51.5
Time in familiar zone, hab. session 10.20.21.3-0.10.10.0-0.00.1-1.1-0.4-0.5
Time in novel zone, hab. session 10.10.10.40.4-0.3-0.10.1-0.10.60.50.5
Total zone transitions, hab. session 10.70.91.6-1.11.20.5-0.50.7-1.1-1.2-1.3
Total locomotion distance, hab. session 19.914.038.24.1-4.0-3.03.0-2.9-6.22.72.6
Locomotion velocity, hab. session 19.213.130.04.1-4.0-3.03.0-3.0-5.52.82.7
Time in familiar zone, hab. session 20.00.00.00.00.00.0-0.0-0.00.1-0.2-0.1
Time in novel zone, hab. session 20.20.20.3-0.30.30.5-0.50.6-0.3-0.2-0.2
Total zone transitions, hab. session 20.20.30.5-0.40.4-0.70.7-0.50.6-0.2-0.3
Total locomotion distance, hab. session 28.411.113.93.6-3.5-3.43.4-3.3-3.72.82.7
Locomotion velocity, hab. session 27.910.712.83.5-3.5-3.43.4-3.3-3.62.72.7
Novel to familiar place preference ratio0.60.63.0-0.00.00.8-0.80.8-1.7-0.4-0.4
Novelty place preference0.90.92.6-0.30.41.0-1.01.1-1.6-0.7-0.7
Time in novel zone, NPP test1.31.32.2-0.70.71.3-1.31.4-1.5-1.0-1.0
Total zone transitions, NPP test0.91.33.20.6-0.6-1.81.8-1.50.30.80.7
Total locomotion distance, NPP test12.116.621.44.6-4.6-4.14.1-3.9-4.03.63.5
Locomotion velocity, NPP test13.118.624.04.9-4.8-4.34.3-4.2-4.33.83.7
Intraocular pressure1.11.63.8-0.40.41.4-1.41.5-2.0-1.0-1.1
Delta distance traveled before/after self-admin0.20.30.50.7-0.70.3-0.30.3-0.10.70.7
Delta ambulatory time before/after self-admin0.20.30.80.5-0.50.4-0.40.3-0.90.40.3
Parametrial fat weight1.42.74.02.0-2.0-1.61.6-1.7-0.41.61.8
Pavlov. Cond. lever latency0.30.41.01.0-1.0-0.20.2-0.3-0.50.80.6
Pavlov. Cond. magazine entry latency0.10.10.40.1-0.10.1-0.10.1-0.6-0.3-0.2
Pavlov. Cond. change in total contacts0.90.91.4-0.90.91.0-1.01.20.1-1.1-1.1
Pavlov. Cond. index score0.20.30.6-0.60.60.4-0.40.4-0.2-0.8-0.7
Pavlov. Cond. latency score0.10.10.2-0.30.4-0.00.00.00.1-0.4-0.3
Pavlov. Cond. lever contacts0.70.81.6-1.21.20.4-0.40.50.5-1.1-1.0
Pavlov. Cond. magazine entry number0.70.92.30.4-0.5-0.90.9-0.81.51.00.9
Pavlov. Cond. intertrial magazine entries2.42.94.2-1.51.51.8-1.82.0-0.8-1.9-1.9
Pavlov. Cond. lever-magazine prob. diff.0.50.61.2-0.90.90.6-0.60.7-0.2-1.1-1.0
Pavlov. Cond. response bias0.70.91.4-1.01.00.9-0.90.9-0.3-1.2-1.1
Pavlov. Cond. lever latency0.20.30.80.3-0.3-0.40.4-0.60.60.90.7
Pavlov. Cond. magazine entry latency0.10.10.4-0.20.20.3-0.30.40.3-0.6-0.4
Pavlov. Cond. change in total contacts0.00.10.20.4-0.4-0.00.00.10.3-0.2-0.0
Pavlov. Cond. index score0.20.20.8-0.20.10.4-0.40.50.0-0.9-0.6
Pavlov. Cond. latency score0.20.20.7-0.10.10.3-0.30.5-0.1-0.8-0.6
Pavlov. Cond. lever contacts0.20.30.9-0.40.40.4-0.40.6-0.2-0.9-0.6
Pavlov. Cond. magazine entry number0.10.20.4-0.10.1-0.40.4-0.5-0.40.60.5
Pavlov. Cond. intertrial magazine entries1.62.13.11.3-1.3-1.71.7-1.70.31.61.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.1-0.20.1-0.10.20.4-0.6-0.3
Pavlov. Cond. response bias0.30.51.2-0.40.40.7-0.70.8-0.3-1.1-0.8
Time in closed arm before self-admin0.20.20.80.3-0.30.2-0.20.20.90.50.3
Time in closed arm after self-admin0.90.91.31.1-1.1-1.11.1-0.80.90.70.9
Time in open arm before self-admin2.22.33.71.4-1.3-1.71.7-1.8-1.91.11.2
Time in open arm after self-admin0.40.41.40.7-0.7-0.10.1-0.4-1.20.70.6
Bone: periosteal estimation0.71.52.10.5-0.6-1.41.4-1.31.41.31.3
Bone: periosteal perimeter0.40.70.90.8-0.8-0.90.9-0.8-0.10.90.9
Bone: post-yield work0.10.10.2-0.30.30.4-0.40.4-0.3-0.2-0.2
Progressive ratio test 1 active lever presses0.40.40.7-0.50.50.8-0.80.8-0.3-0.6-0.6
Progressive ratio test 1 breakpoint0.20.20.4-0.30.30.5-0.50.6-0.4-0.3-0.3
Progressive ratio test 1 inactive lever presses0.10.20.5-0.20.2-0.10.10.2-0.5-0.7-0.6
Progressive ratio test 2 active lever presses1.61.72.9-0.70.71.6-1.61.7-1.2-1.1-1.3
Progressive ratio test 2 breakpoint0.91.01.7-0.40.41.2-1.21.3-1.1-0.8-1.0
Progressive ratio test 2 inactive lever presses2.52.95.4-0.70.81.9-1.91.8-2.3-1.5-2.0
Incentive Sensitization - Responses2.82.84.2-1.41.42.0-2.02.0-0.4-1.6-2.0
Incentive Sensitization - Breakpoint2.72.74.0-1.41.42.0-2.02.0-0.5-1.5-1.9
Sum of active levers in priming session hrs 5-60.20.20.4-0.60.50.7-0.70.30.3-0.3-0.2
Progressive ratio4.75.56.92.6-2.6-2.32.3-2.40.42.62.6
Food seeking constrained by brief footshock2.43.04.41.6-1.6-1.91.9-1.90.42.02.1
Seeking ratio, punishment vs. effort0.50.61.2-1.11.10.7-0.70.80.0-0.7-0.7
Retroperitoneal fat weight0.62.12.71.5-1.5-1.41.4-1.50.91.61.6
Reaction time number correct0.20.21.5-0.10.1-0.20.2-0.11.20.40.3
Reaction time mean minus median1.72.22.5-1.51.51.5-1.51.51.6-1.4-1.4
Reaction time mean minus median AUC3.14.05.0-2.12.12.2-2.22.21.2-1.8-1.9
Reaction time num false alarms0.10.20.3-0.30.30.5-0.50.5-0.0-0.2-0.4
Reaction time num false alarms AUC0.10.20.2-0.40.40.4-0.40.40.0-0.2-0.5
Reaction time trials correct on left0.20.21.5-0.10.1-0.20.2-0.11.20.40.3
Reaction time trials on left0.20.31.7-0.20.2-0.10.1-0.01.30.30.3
Reaction time mean2.02.74.0-2.01.91.5-1.51.42.0-1.4-1.4
Reaction time mean AUC2.02.63.9-2.01.91.4-1.41.31.9-1.5-1.5
Median of all reaction times1.62.33.6-1.81.81.3-1.31.21.9-1.2-1.3
Reaction time omissions2.43.27.9-2.01.91.4-1.41.52.8-1.5-1.4
Reaction time false alarm rate0.20.30.8-0.30.30.6-0.60.6-0.9-0.5-0.6
Reaction time premature initiation rate5.57.49.1-3.03.02.8-2.82.81.3-2.9-2.7
Reaction time premature initiations4.05.67.3-2.72.72.3-2.32.32.2-2.2-2.2
Std. dev. reaction times1.41.93.1-1.71.61.1-1.11.11.8-1.2-1.2
Reaction time trials completed0.20.31.7-0.20.2-0.10.1-0.01.30.30.3
Reaction time trials AUC0.10.21.3-0.30.30.0-0.00.11.20.20.2
Run reversals in cocaine runway, females0.40.30.6-0.50.5-0.60.6-0.70.7-0.5-0.5
Run reversals in cocaine runway, males0.70.71.30.5-0.5-0.90.9-0.90.71.20.8
Latency to leave start box in cocaine runway3.63.95.32.0-2.0-2.12.1-2.30.71.92.2
Latency to leave start box in cocaine runway, F1.41.62.61.2-1.2-1.41.4-1.61.01.01.1
Latency to leave start box in cocaine runway, M2.72.64.21.9-1.9-1.51.5-1.7-0.51.52.1
Std. dev. time between licks in bursts0.20.21.4-0.10.10.2-0.20.2-1.2-0.4-0.4
Total sessions with >9 infusions0.20.20.40.1-0.10.6-0.60.6-0.2-0.3-0.4
Short access day 1 total inactive lever presses1.21.32.91.7-1.7-1.01.0-0.7-1.11.10.6
Short access day 10 total inactive lever presses2.93.24.71.9-1.9-2.22.2-1.8-0.51.81.6
Short access day 1 total infusions0.80.91.9-0.40.41.4-1.41.30.1-0.6-0.8
Short access day 10 total infusions1.21.32.0-0.90.91.2-1.21.4-0.5-1.4-1.3
Short access total infusions0.40.51.1-0.30.20.9-0.91.1-0.2-0.6-0.6
Short access day 1 locomotion0.30.30.70.4-0.4-0.80.8-0.8-0.20.40.3
Short access day 10 total locomotion0.50.51.11.1-1.1-0.60.6-0.6-0.10.50.8
Short access total locomotion0.70.71.11.0-1.0-1.01.0-0.9-0.20.60.8
One hour access (0.3 mA shock)1.41.62.8-1.11.11.1-1.11.2-1.5-1.7-1.2
Compulsive drug intake1.41.42.41.3-1.3-1.11.1-1.2-0.51.31.5
One hour access (shock baseline)2.73.14.7-2.02.01.6-1.61.7-0.2-2.2-2.0
Social response proportion0.70.75.9-0.20.1-0.10.1-0.12.4-0.00.1
Social responses2.22.83.91.3-1.4-1.81.8-1.92.01.51.5
Social time0.91.26.9-1.11.1-0.00.0-0.42.6-0.5-0.5
Soleus weight0.20.71.0-1.01.00.8-0.80.70.1-1.0-1.0
Bone: stiffness0.50.71.90.1-0.1-0.90.9-0.71.41.00.9
Tibialis anterior weight1.13.66.0-2.42.41.6-1.61.51.9-1.7-1.7
Time to tail flick, vehicle, before self-admin0.30.30.8-0.50.50.3-0.30.10.3-0.8-0.9
Time to tail flick, vehicle, after self-admin5.15.57.62.8-2.8-2.52.5-2.4-0.32.42.2
Time to tail flick, test, before self-admin0.20.21.10.4-0.4-0.10.10.0-1.00.20.1
Time to tail flick, test, after self-admin1.51.52.21.5-1.5-1.41.4-1.2-0.31.11.2
Delta time to tail flick, vehicle, before/after SA0.20.20.90.3-0.3-0.20.2-0.00.90.60.6
Delta time to tail flick, test, before/after SA0.10.10.10.4-0.4-0.30.3-0.30.30.10.2
Tibia length0.00.10.5-0.00.0-0.30.3-0.30.70.20.0
Ambulatory time before self-admin0.91.04.1-0.20.2-0.90.9-1.22.00.60.6
Ambulatory time after self-admin0.20.31.3-0.50.50.3-0.30.01.20.20.1
Bone: tissue strength1.81.72.41.1-1.1-1.51.5-1.50.91.51.3
Total heroin consumption0.00.00.10.1-0.10.3-0.30.2-0.0-0.3-0.2
Bone: trabecular number0.20.42.3-0.50.50.0-0.00.11.50.10.0
Bone: trabecular spacing0.10.10.70.3-0.2-0.20.2-0.2-0.80.00.0
Bone: trabecular thickness0.81.01.5-1.01.01.2-1.21.20.3-0.8-0.9
Bone: trabecular tissue density1.11.52.30.9-0.9-1.51.5-1.21.01.31.3
Water consumed over 24 hours1.51.82.2-1.41.51.5-1.51.5-0.4-1.3-1.4
Number of responses in last shaping day0.40.51.31.1-1.1-0.00.00.1-0.80.60.4