LOC108352411

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC108352411	0.07	0.04	2.2e-07	0.09	0.08	0.07	0.07	2.1e-08	4.5e-08	3.0e-07	1.8e-07
2	Brain	isoform ratio	XR_005491694.1	0.04	0.03	9.1e-03	0.01	0.01	0.01	0.01	2.6e-02	2.5e-02	3.7e-02	1.8e-02
3	Brain	alternative polyA	XR_001840619.2	0.05	0.04	3.5e-03	0.02	0.02	0.02	0.01	5.1e-03	7.8e-03	9.8e-03	1.4e-02
4	Brain	alternative polyA	XR_005491694.1	0.05	0.04	3.5e-03	0.02	0.02	0.02	0.01	7.0e-03	7.3e-03	9.5e-03	1.4e-02
5	PL	isoform ratio	XR_005491694.1	0.04	0.02	1.4e-04	0.02	0.03	0.02	0.02	6.8e-03	7.2e-04	2.7e-03	3.2e-03
6	PL	gene expression	LOC108352411	0.06	0.04	9.2e-08	0.05	0.06	0.06	0.06	1.8e-06	2.3e-07	3.0e-07	2.5e-07
7	NAcc	gene expression	LOC108352411	0.02	0.01	2.4e-03	0.01	0.01	0.01	0.01	6.7e-03	7.9e-03	5.8e-02	4.6e-02
8	IL	gene expression	LOC108352411	0.14	0.1	3.8e-03	0.06	0.08	0.04	0.03	1.5e-02	6.4e-03	3.6e-02	5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	5.8	9.7	16.9	4.1	4.0	3.5	-3.5	3.3	-2.1	1.9	-1.0
Area under the delay curve	0.8	0.8	1.4	-1.0	-1.1	-1.2	1.2	-0.9	0.6	-0.7	0.2
BMI with tail	2.1	6.7	11.8	3.4	2.5	2.9	-2.9	3.0	-2.1	1.9	-1.2
BMI without tail	0.3	0.7	2.2	-0.1	-0.4	-0.3	0.3	-0.4	1.1	-1.3	1.5
Body weight	6.9	29.1	55.8	7.5	7.1	6.3	-6.3	5.7	-3.0	2.4	-0.1
Weight adjusted by age	1.1	1.2	3.0	1.3	1.7	0.4	-0.4	-0.1	1.0	-1.1	1.6
Bone surface	5.0	8.9	16.1	4.0	4.0	3.6	-3.6	3.0	-1.6	1.4	-0.4
Bone volume	6.2	10.5	17.4	4.2	3.8	3.6	-3.6	3.5	-2.4	2.2	-1.5
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.7	-0.6	-0.6	0.6	-0.6	0.4	-0.5	0.2
Number of licking bursts	0.6	0.8	2.6	1.1	1.1	0.4	-0.4	0.2	0.5	-0.6	1.6
Context. condit. distance diff. score	1.7	2.0	3.1	1.4	1.5	1.8	-1.8	1.6	-1.2	1.0	-1.0
Locomotion velocity, session 1	0.9	1.0	1.4	-1.2	-0.6	-0.7	0.7	-1.2	1.2	-1.1	1.1
Locomotion distance, session 1	1.5	2.0	3.4	-1.0	-0.7	-1.2	1.2	-1.7	1.8	-1.8	1.4
Locomotion velocity, session 2	1.0	1.2	3.5	-0.7	-0.1	-0.2	0.2	-1.2	1.4	-1.4	1.9
Locomotion distance, session 2	2.3	3.2	6.9	-0.8	-0.4	-1.0	1.0	-2.0	2.4	-2.4	2.6
Locomotion velocity, session 3	0.7	0.9	1.3	1.1	1.0	0.8	-0.8	1.0	-0.9	0.9	-0.7
Locomotion distance, session 3	0.1	0.1	0.3	0.1	0.2	-0.4	0.4	-0.3	0.4	-0.5	0.2
Stereotopy head waving bouts, day 3	0.7	0.8	2.1	-0.4	0.0	-0.2	0.2	-0.7	1.4	-1.2	1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.2	-0.4	0.5	-0.3	0.2
Locomotion velocity, session 7	0.1	0.1	0.4	-0.0	0.1	-0.7	0.7	-0.1	-0.1	0.1	-0.4
Locomotion distance, session 7	0.0	0.0	0.1	-0.1	-0.0	-0.4	0.4	-0.2	0.2	-0.0	-0.2
Stereotopy head waving bouts, day 7	2.8	3.2	4.4	-2.0	-1.9	-1.9	1.9	-2.1	1.7	-1.6	1.0
Stereotopy head waving duration, day 7	1.1	1.4	2.0	-1.4	-1.2	-1.2	1.2	-1.4	1.1	-1.2	0.8
Locomotion velocity, session 8	0.8	0.9	2.0	-0.9	-0.3	-0.4	0.4	-1.2	1.2	-1.4	1.2
Locomotion distance, session 8	0.5	0.7	1.4	0.7	1.2	1.0	-1.0	0.1	0.6	-0.8	0.9
Degree of sensitization distance	0.3	0.3	0.8	-0.9	-0.8	-0.5	0.5	-0.7	0.4	-0.3	0.3
Degree of sensitization stereotypy	1.0	1.1	1.9	-1.4	-1.3	-1.1	1.1	-1.3	0.7	-0.8	0.3
Conditioned locomotion	0.1	0.1	0.5	-0.0	-0.3	-0.3	0.3	-0.4	0.7	-0.4	0.3
Cocaine response after cond. corrected	0.5	0.5	1.5	-0.5	-0.9	-0.5	0.5	0.1	-0.6	0.9	-1.2
Cocaine response after cond. not corrected	0.7	0.7	2.4	-0.5	-1.0	-0.5	0.5	0.2	-0.7	1.1	-1.5
Cocaine response before conditioning	0.2	0.3	0.3	0.5	0.4	0.5	-0.5	0.5	-0.5	0.5	-0.5
Saline control response	2.2	2.9	8.2	-0.4	0.1	-0.5	0.5	-1.4	2.3	-2.6	2.9
Bone: connectivity density	4.5	7.1	15.6	3.6	3.9	3.2	-3.2	2.5	-1.0	0.8	0.4
Bone: cortical apparent density	0.3	0.4	0.8	0.4	0.4	0.3	-0.3	0.6	-0.8	0.9	-0.7
Bone: cortical area	2.1	3.2	5.8	2.4	2.1	2.0	-2.0	2.0	-1.2	1.0	-0.6
Bone: cortical porosity	1.7	1.9	2.7	-1.6	-1.4	-1.2	1.2	-1.6	1.4	-1.2	1.0
Bone: cortical porosity	1.8	2.0	2.9	-1.7	-1.5	-1.2	1.2	-1.7	1.5	-1.3	1.0
Bone: cortical thickness	1.6	2.6	4.7	2.2	1.9	1.8	-1.8	1.8	-1.2	1.0	-0.6
Bone: cortical thickness	0.4	0.5	0.9	0.2	-0.2	-0.8	0.8	-0.6	0.9	-0.9	0.9
Bone: cortical tissue density	0.2	0.3	0.7	0.3	0.3	0.2	-0.2	0.5	-0.8	0.9	-0.8
Condit. Reinf. active minus inactive responses	1.2	1.4	2.5	1.6	1.4	1.2	-1.2	1.3	-1.0	0.7	-0.6
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.3	1.4	1.1	1.1	-1.1	1.5	-1.4	1.1	-1.2
Condit. Reinf. active responses	0.1	0.2	0.6	0.8	0.7	0.2	-0.2	0.5	-0.3	0.1	-0.1
Condit. Reinf. inactive responses	0.7	0.8	1.4	-0.9	-0.8	-1.2	1.2	-1.0	0.8	-0.6	0.6
Incentive salience index mean	0.3	0.3	0.6	0.8	0.7	0.3	-0.3	0.7	-0.5	0.5	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.4	-0.5	-0.9	0.9	-0.3	0.1	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.7	0.9	1.9	-0.5	-0.3	-0.9	0.9	-0.8	1.1	-1.1	1.4
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.5	-0.9	-0.7	-1.4	1.4	-1.2	1.5	-1.5	1.6
Condit. Reinf. active responses	0.3	0.4	1.4	0.0	0.3	-0.2	0.2	-0.4	0.9	-0.8	1.2
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.7	0.8	0.9	-0.9	0.4	-0.2	0.3	0.0
Condit. Reinf. lever presses	0.4	0.5	1.2	1.1	0.9	0.5	-0.5	0.9	-0.4	0.5	-0.4
Condit. Reinf. lever reinforcers received	0.2	0.3	1.3	0.2	0.4	-0.2	0.2	-0.3	0.8	-0.7	1.1
Conditioned reinforcement - actives	0.5	0.5	1.2	0.2	0.9	1.1	-1.1	0.1	0.2	-0.2	0.9
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.2	0.0	-0.3	0.3	-0.0	-0.2	0.6	-0.2
Conditioned locomotion	0.1	0.2	0.8	-0.5	-0.2	0.2	-0.2	-0.1	0.3	-0.3	0.9
Patch foraging indifference point 0 sec	1.6	2.6	4.8	2.2	1.7	1.6	-1.6	1.8	-1.3	1.5	-1.0
Patch foraging indifference point AUC	0.1	0.1	0.4	0.3	0.2	0.1	-0.1	0.1	0.4	-0.3	0.6
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.9	0.7	0.6	-0.6	0.4	-0.4	0.2	-0.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	-0.8	-0.9	-0.8	0.8	-0.1	-0.2	0.0	-0.6
Delay disc. indifference point, 2s delay	0.6	0.7	1.2	-0.9	-1.0	-0.9	0.9	-1.1	0.6	-0.3	-0.1
Delay disc. indifference point, 24s delay	0.4	0.4	0.9	-0.7	-0.9	-0.9	0.9	-0.5	0.2	-0.5	-0.0
Delay disc. indifference point, 4s delay	0.7	0.8	1.5	-1.0	-1.2	-1.2	1.2	-0.6	0.4	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.4	0.4	0.7	-0.5	-0.6	-0.8	0.8	-0.6	0.6	-0.7	0.3
Indifference point function ln k	0.3	0.4	1.2	0.7	1.1	0.9	-0.9	0.4	-0.3	0.1	0.2
Indifference point function log k	0.3	0.4	1.2	0.7	1.1	0.9	-0.9	0.4	-0.3	0.1	0.2
Patch foraging total patch changes 0 sec	1.4	2.3	4.5	2.1	1.6	1.4	-1.4	1.7	-1.2	1.4	-1.0
Patch foraging total patch changes 12 sec	2.2	2.8	3.8	1.9	1.4	1.7	-1.7	2.0	-1.5	1.8	-1.3
Patch foraging total patch changes 18 sec	0.3	0.3	0.7	0.6	0.2	0.3	-0.3	0.8	-0.6	0.9	-0.6
Patch foraging total patch changes 24 sec	0.3	0.3	1.1	1.1	0.4	0.0	-0.0	0.7	-0.3	0.8	-0.5
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	0.9	0.5	0.4	-0.4	0.8	-0.3	0.7	-0.4
Patch foraging time to switch 0 sec	0.8	1.2	2.1	-1.3	-1.4	-1.0	1.0	-0.4	-0.5	1.0	-1.5
Patch foraging water rate 0 sec	1.1	1.8	3.7	1.9	1.9	1.5	-1.5	1.3	-0.3	-0.0	0.8
Patch foraging water rate 12 sec	0.5	0.8	1.6	1.2	1.3	0.7	-0.7	0.4	0.2	-0.7	1.2
Patch foraging water rate 18 sec	0.7	1.0	1.6	-0.7	-0.7	-0.9	0.9	-0.9	1.1	-1.3	1.2
Patch foraging water rate 24 sec	1.0	1.3	4.8	0.3	0.5	0.2	-0.2	-0.5	1.4	-1.8	2.2
Patch foraging water rate 6 sec	1.0	1.5	2.8	1.5	1.7	1.4	-1.4	1.4	-1.0	0.6	-0.1
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.7	-1.2	-1.7	-0.9	0.9	-0.6	-0.0	0.3	-0.6
Distance traveled before self-admin	0.5	0.6	1.6	0.0	-0.4	0.0	-0.0	0.6	-1.1	1.2	-1.2
Distance traveled after self-admin	0.1	0.1	0.7	0.8	0.6	-0.1	0.1	0.1	0.1	-0.3	0.2
Extensor digitorum longus weight	1.2	4.8	8.8	3.0	2.9	2.5	-2.5	2.3	-1.4	1.1	-0.3
Bone: elastic displacement	1.5	1.7	2.2	-1.3	-1.1	-1.2	1.2	-1.3	1.4	-1.5	1.4
Bone: elastic work	0.7	0.9	1.8	1.1	1.3	0.9	-0.9	0.5	0.5	-0.7	1.3
Bone: endosteal estimation	0.3	0.7	1.5	0.8	1.2	0.5	-0.5	0.2	0.6	-0.9	1.2
Bone: endosteal perimeter	0.4	0.9	2.5	1.6	1.6	0.8	-0.8	1.0	-0.2	0.0	0.2
Epididymis fat weight	3.3	7.7	9.3	2.9	2.2	2.9	-2.9	3.1	-3.0	2.8	-2.3
Delta time in closed arm before/after self-admin	0.4	0.4	1.3	0.1	0.3	1.1	-1.1	0.5	-0.5	0.2	0.1
Delta time in open arm before/after self-admin	2.6	2.5	5.4	-1.4	-2.1	-2.3	2.3	-1.5	0.7	-0.1	-0.6
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.5	-0.6	-0.7	0.7	-0.0	-0.2	-0.1	-0.5
Delay discount exponential model param	1.0	1.0	1.8	1.2	1.3	1.4	-1.4	0.9	-0.6	0.7	-0.1
Extinction: sum of active levers before priming	1.3	1.3	1.5	1.2	1.0	1.1	-1.1	1.2	-1.2	1.0	-1.2
Active lever presses in extinction session 6	3.5	3.4	5.0	2.2	2.1	2.0	-2.0	1.9	-1.7	1.6	-1.1
Bone: final force	0.6	1.0	2.6	1.5	1.6	1.0	-1.0	0.8	0.1	-0.3	0.8
Bone: final moment	0.6	0.9	2.3	1.5	1.5	0.8	-0.8	0.7	0.1	-0.4	0.8
Food consumed during 24 hour testing period	1.9	2.3	2.8	-1.7	-1.6	-1.6	1.6	-1.5	1.5	-1.4	1.0
Glucose	0.3	0.5	1.0	0.7	0.5	0.6	-0.6	0.7	-1.0	0.7	-0.7
Heart weight	0.5	0.7	2.2	0.1	0.5	-0.1	0.1	-0.4	0.9	-1.5	1.4
Delay discount hyperbolic model param	1.0	1.1	1.9	1.2	1.3	1.4	-1.4	1.0	-0.7	0.7	-0.1
Intermittent access intake day 1-15 change	0.3	0.3	1.2	0.2	0.2	-0.1	0.1	-0.6	0.9	-0.4	1.1
Intermittent access intake escalation	0.4	0.4	1.4	0.2	0.3	-0.2	0.2	-0.6	1.0	-0.4	1.2
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.1	-0.2	-0.3	0.3	-0.6	0.9	-0.7	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.5	0.2	0.7	-0.1	0.1	0.4	-0.4	0.2	0.1
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.9	-0.3	-0.7	-0.5	0.5	0.0	-0.7	1.1	-1.4
Intermitt. access escalation Index	0.2	0.1	0.4	0.1	0.6	0.5	-0.5	0.2	-0.1	-0.4	0.2
Intermittent access day 1 total infusions	2.2	2.6	5.3	-2.3	-1.9	-1.6	1.6	-2.0	1.4	-0.8	0.4
Intermittent access day 15 total infusions	2.3	2.5	4.3	-1.7	-1.3	-1.4	1.4	-2.1	2.0	-1.2	1.5
Intermittent access terminal intake (last 3 days)	1.9	2.1	3.7	-1.9	-1.6	-1.3	1.3	-1.9	1.6	-0.7	0.8
Intermittent access total infusions	3.3	3.6	6.2	-2.5	-2.1	-1.9	1.9	-2.4	1.9	-1.1	0.9
Intermittent access day 1 locomotion	1.6	1.7	4.4	-2.1	-1.8	-1.1	1.1	-1.6	0.9	-0.2	0.2
Intermittent access day 15 total locomotion	2.0	2.1	3.3	-1.6	-1.3	-1.4	1.4	-1.8	1.7	-1.0	1.4
Intermittent access total locomotion	2.3	2.6	4.7	-2.2	-1.9	-1.6	1.6	-2.1	1.5	-0.7	0.9
Intermittent access standard deviation	0.1	0.1	0.2	-0.0	-0.1	-0.1	0.1	-0.3	0.4	-0.3	0.4
Left kidney weight	4.3	12.1	23.7	4.5	4.9	4.1	-4.1	3.7	-1.9	1.0	0.4
Right kidney weight	5.7	16.0	28.8	5.1	5.4	4.8	-4.8	4.2	-2.5	1.7	0.1
Cocaine induced anxiety	0.1	0.2	0.6	-0.1	-0.4	0.4	-0.4	0.1	-0.4	0.2	-0.8
Post-drug Anxiety	2.4	2.7	6.0	-2.4	-2.4	-1.6	1.6	-1.7	0.7	-0.8	-0.3
Baseline Anxiety	0.9	1.0	2.1	-1.5	-1.4	-1.1	1.1	-0.7	-0.2	0.4	-0.7
Tail length	0.9	2.6	9.3	0.4	0.9	-0.3	0.3	-0.8	2.1	-2.2	3.0
Length with tail	3.8	13.9	33.5	5.3	5.8	4.2	-4.2	3.4	-0.9	0.4	1.6
Length without tail	13.1	28.7	46.8	6.8	6.8	6.0	-6.0	5.7	-4.0	3.4	-1.8
Times rat made contact with spout	0.9	1.0	3.4	0.2	0.6	-0.2	0.2	-0.7	1.1	-1.5	1.8
Lifetime Intake	2.2	2.5	4.9	-2.2	-1.9	-1.6	1.6	-2.1	1.4	-0.6	0.3
Liver weight, left	3.1	5.0	9.9	3.1	3.2	2.4	-2.4	2.3	-1.4	1.2	-0.6
Liver weight, right	3.8	6.4	13.3	3.3	3.6	3.1	-3.1	2.4	-0.9	0.5	0.7
Locomotor activity	0.2	0.3	0.9	0.6	0.8	0.4	-0.4	0.4	0.1	-0.5	1.0
Locomotor testing distance	0.1	0.2	0.5	0.7	0.6	0.1	-0.1	0.6	-0.3	-0.0	0.4
Locomotor testing rearing	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	-0.0	0.1	-0.1	0.1
Locomotion in novel chamber	3.3	4.1	6.6	-1.6	-1.4	-1.4	1.4	-2.2	2.4	-2.6	2.6
Locomotion in novel chamber post-restriction	2.4	2.9	7.1	-0.8	-0.6	-1.0	1.0	-1.4	2.2	-2.5	2.7
Fecal boli incidents, locomotor time 1	0.8	0.8	1.8	0.8	1.2	1.3	-1.3	0.9	-0.5	0.2	0.4
Change in fecal boli incidents, locomotor task	0.4	0.4	1.1	-0.8	-1.0	-0.7	0.7	-0.4	-0.1	-0.0	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.9	0.2	0.1	0.1	-0.1	0.0	-0.3	0.3	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	0.0	-0.4	0.4	0.3	0.1	-0.1	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.1	0.0	-0.4	0.4	0.4	-0.0	0.0	0.2
Rest time, locomotor task time 1	0.8	0.9	1.2	-1.0	-0.7	-1.1	1.1	-0.8	0.9	-0.8	0.9
Distance moved, locomotor task time 1	0.4	0.4	0.9	0.7	0.9	0.9	-0.9	0.4	-0.3	-0.0	-0.0
Vertical activity count, locomotor time 1	1.0	1.1	1.8	1.2	1.3	1.3	-1.3	1.1	-0.7	0.3	-0.1
Time >=10cm from walls, locomotor time 2	0.9	1.0	2.4	1.5	1.5	0.9	-0.9	0.9	-0.6	0.5	-0.4
Bouts of movement, locomotor time 2	2.0	2.2	4.8	2.2	2.2	1.6	-1.6	1.4	-0.6	0.8	0.2
Total resting periods, locomotor time 2	2.2	2.4	4.8	2.2	2.1	1.6	-1.6	1.5	-0.9	1.1	-0.2
Rest time, locomotor task time 2	0.3	0.4	1.0	-0.7	-1.0	-0.7	0.7	-0.5	0.2	-0.1	-0.4
Distance moved, locomotor task time 2	0.4	0.5	1.4	0.8	1.2	0.5	-0.5	0.3	0.3	-0.4	1.1
Vertical activity count, locomotor time 2	1.1	1.2	3.0	1.3	1.7	1.1	-1.1	1.2	-0.4	0.0	0.8
Light reinforcement 1	0.3	0.5	1.1	-0.8	-1.0	-0.9	0.9	-0.7	0.1	0.1	-0.4
Light reinforcement 2	0.2	0.2	0.4	-0.5	-0.6	-0.5	0.5	0.0	-0.4	0.6	-0.6
Bone: marrow area	0.3	0.6	1.5	0.8	1.2	0.4	-0.4	0.1	0.6	-0.9	1.2
Bone: maximum diameter	1.0	1.8	3.9	2.0	1.8	1.5	-1.5	1.4	-0.6	0.4	-0.1
Bone: maximum force	1.1	1.9	4.7	2.1	2.2	1.5	-1.5	1.2	-0.2	0.0	0.3
Bone: maximum moment	1.0	1.7	4.3	2.0	2.1	1.4	-1.4	1.2	-0.2	-0.0	0.3
Mean time between licks in bursts	0.7	1.0	1.8	-1.4	-1.3	-1.2	1.2	-1.0	0.7	-0.3	0.3
Mean num. licks in bursts	0.5	0.6	1.1	-1.1	-0.8	-0.8	0.8	-0.9	0.6	-0.7	-0.0
Cd content in liver	0.7	0.8	1.6	-1.3	-1.2	-0.9	0.9	-0.8	0.5	-0.7	0.6
Co content in liver	2.5	3.0	3.7	-1.8	-1.9	-1.9	1.9	-1.9	1.7	-1.5	1.1
Cu content in liver	2.3	2.8	3.8	2.0	1.8	1.8	-1.8	1.9	-1.6	1.2	-0.8
Fe content in liver	10.7	12.9	17.4	4.2	3.9	3.7	-3.7	4.1	-3.4	3.2	-2.1
K content in liver	0.7	0.7	1.0	-0.8	-0.8	-1.0	1.0	-0.9	0.8	-0.7	0.4
Mg content in liver	0.7	0.7	0.9	-0.8	-1.0	-1.0	1.0	-0.9	0.8	-0.6	0.6
Mn content in liver	0.1	0.1	0.3	-0.2	0.2	-0.1	0.1	-0.5	0.5	-0.5	0.6
Na content in liver	0.1	0.1	0.3	0.2	0.6	0.3	-0.3	0.0	0.1	0.0	0.1
Rb content in liver	0.7	0.8	2.7	-0.6	-1.0	-0.2	0.2	0.3	-1.0	1.1	-1.6
Se content in liver	2.1	2.6	4.3	1.3	1.1	1.2	-1.2	1.8	-1.9	2.1	-2.0
Sr content in liver	0.3	0.3	1.0	0.1	0.3	-0.1	0.1	-0.3	0.7	-0.8	1.0
Zn content in liver	2.8	3.0	5.2	2.2	2.2	2.3	-2.3	1.7	-1.0	0.7	0.2
Bone: minimum diameter	0.0	0.0	0.1	0.2	-0.1	0.1	-0.1	0.1	-0.0	-0.3	0.0
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.6	0.8	0.7	-0.7	0.5	-0.4	0.4	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.7	0.5	0.5	-0.5	0.5	-0.3	0.2	0.2
Total zone transitions, hab. session 1	3.0	4.3	6.7	-1.9	-1.1	-1.8	1.8	-2.4	2.6	-2.4	2.2
Total locomotion distance, hab. session 1	0.9	1.3	1.8	-1.0	-1.0	-1.4	1.4	-1.4	1.3	-1.0	0.6
Locomotion velocity, hab. session 1	1.9	2.8	4.1	-1.8	-1.8	-2.0	2.0	-1.9	1.5	-1.1	0.4
Time in familiar zone, hab. session 2	2.6	2.7	3.3	1.7	1.5	1.8	-1.8	1.7	-1.8	1.5	-1.3
Time in novel zone, hab. session 2	1.8	1.8	2.6	-1.6	-1.5	-1.5	1.5	-1.4	1.3	-0.9	0.7
Total zone transitions, hab. session 2	3.3	4.2	7.1	-1.5	-0.8	-1.5	1.5	-2.2	2.6	-2.7	2.7
Total locomotion distance, hab. session 2	2.9	3.8	5.1	-1.8	-1.6	-2.0	2.0	-2.2	2.2	-2.1	1.5
Locomotion velocity, hab. session 2	3.1	4.1	5.4	-1.8	-1.7	-2.2	2.2	-2.3	2.3	-2.1	1.6
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.7	-0.6	-0.4	0.4	-0.6	0.3	-0.3	0.4
Novelty place preference	0.1	0.1	0.2	-0.5	-0.4	-0.1	0.1	-0.4	-0.0	-0.1	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2	-0.2	-0.1	-0.1	0.2
Total zone transitions, NPP test	1.2	1.7	3.6	-0.7	-0.2	-0.7	0.7	-1.4	1.8	-1.8	1.9
Total locomotion distance, NPP test	1.6	2.2	2.8	-1.4	-1.5	-1.7	1.7	-1.7	1.6	-1.3	0.8
Locomotion velocity, NPP test	2.4	3.4	4.3	-1.7	-1.8	-2.1	2.1	-2.1	2.0	-1.7	1.2
Intraocular pressure	0.4	0.6	0.8	0.6	0.5	0.7	-0.7	0.9	-0.9	0.8	-0.7
Delta distance traveled before/after self-admin	1.2	1.3	3.4	0.3	0.4	-0.5	0.5	-0.9	1.6	-1.9	1.7
Delta ambulatory time before/after self-admin	0.7	0.8	2.1	0.5	0.6	-0.4	0.4	-0.7	1.2	-1.4	1.2
Parametrial fat weight	0.1	0.2	0.4	0.6	0.7	0.4	-0.4	0.6	-0.4	0.3	0.1
Pavlov. Cond. lever latency	4.3	5.4	7.5	2.7	2.7	2.7	-2.7	2.6	-2.1	1.6	-0.7
Pavlov. Cond. magazine entry latency	2.5	3.2	4.2	-1.5	-1.3	-1.9	1.9	-1.9	2.1	-2.0	1.7
Pavlov. Cond. change in total contacts	0.6	0.7	1.4	-0.9	-0.8	-1.2	1.2	-0.8	0.6	-0.3	0.1
Pavlov. Cond. index score	2.3	3.0	4.2	-1.8	-1.7	-2.1	2.1	-1.9	1.7	-1.4	0.9
Pavlov. Cond. latency score	3.1	4.0	5.6	-2.0	-2.0	-2.4	2.4	-2.2	2.0	-1.7	1.1
Pavlov. Cond. lever contacts	4.0	4.6	7.4	-2.5	-2.6	-2.7	2.7	-2.3	1.7	-1.1	0.4
Pavlov. Cond. magazine entry number	1.2	1.5	2.0	1.1	0.9	1.2	-1.2	1.3	-1.4	1.4	-1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.7	0.6	0.2	-0.2	0.5	-0.5	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.6	-1.7	-1.6	-1.9	1.9	-1.7	1.5	-1.2	0.7
Pavlov. Cond. response bias	2.0	2.4	3.2	-1.7	-1.6	-1.8	1.8	-1.6	1.5	-1.3	0.9
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.2	0.3	-0.3	0.2	-0.3	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	-0.9	-0.5	-0.6	0.6	-0.3	-0.1	0.3	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.3	0.5	0.4	-0.4	0.2	0.0	0.0	0.3
Pavlov. Cond. index score	0.1	0.1	0.3	-0.5	-0.3	-0.5	0.5	-0.3	0.3	-0.0	0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	-0.2	-0.4	0.4	-0.2	0.2	0.1	-0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.0	-0.5	-0.4	0.4	0.1	-0.2	0.5	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.5	0.5	0.4	-0.4	0.1	0.3	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.3	0.1	0.0	-0.4	0.4	-0.5	0.9	-0.9	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.4	-0.2	-0.5	0.5	-0.3	0.3	-0.1	0.1
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.4	-0.8	-0.6	0.6	-0.1	-0.2	0.6	-0.7
Time in closed arm before self-admin	0.4	0.5	1.2	0.3	0.8	0.9	-0.9	0.2	0.3	-0.4	1.1
Time in closed arm after self-admin	1.9	1.9	4.9	0.8	1.4	2.2	-2.2	0.6	0.0	-0.4	1.5
Time in open arm before self-admin	0.5	0.5	0.9	1.0	1.0	1.0	-1.0	0.6	-0.3	-0.2	0.0
Time in open arm after self-admin	0.9	1.0	2.6	-0.7	-1.2	-1.6	1.6	-0.7	0.2	0.0	-0.6
Bone: periosteal estimation	0.8	1.6	3.8	1.8	2.0	1.4	-1.4	1.1	-0.2	-0.2	0.5
Bone: periosteal perimeter	1.5	2.5	5.2	2.3	2.1	1.6	-1.6	1.8	-1.1	0.9	-0.6
Bone: post-yield work	0.2	0.2	0.6	0.7	0.6	0.4	-0.4	0.5	-0.2	0.2	-0.5
Progressive ratio test 1 active lever presses	0.3	0.4	0.8	-0.6	-0.2	-0.2	0.2	-0.8	0.9	-0.4	0.9
Progressive ratio test 1 breakpoint	0.8	0.8	1.6	-0.8	-0.5	-0.6	0.6	-1.2	1.3	-0.8	1.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	-0.1	0.2	-0.2	0.2	-0.4	0.4	-0.3	0.7
Progressive ratio test 2 active lever presses	1.3	1.4	2.6	-1.3	-0.7	-0.7	0.7	-1.4	1.5	-1.3	1.6
Progressive ratio test 2 breakpoint	2.2	2.5	3.4	-1.6	-1.2	-1.2	1.2	-1.8	1.9	-1.6	1.8
Progressive ratio test 2 inactive lever presses	0.3	0.3	1.4	-0.4	-0.1	-0.2	0.2	-0.4	0.7	-0.6	1.2
Incentive Sensitization - Responses	1.5	1.5	2.2	-1.5	-1.3	-1.2	1.2	-1.3	1.2	-1.2	0.9
Incentive Sensitization - Breakpoint	1.4	1.5	2.0	-1.4	-1.3	-1.2	1.2	-1.3	1.2	-1.2	0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	0.5	0.4	0.0	-0.0	0.1	-0.0	0.2	-0.5
Progressive ratio	0.4	0.4	0.9	-0.6	-0.7	-0.8	0.8	-0.9	0.5	-0.3	-0.0
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.1	0.1	0.7	-0.7	0.3	-0.2	0.3	-0.1
Seeking ratio, punishment vs. effort	0.5	0.6	1.6	0.5	0.8	1.2	-1.2	0.8	-0.2	0.1	0.5
Retroperitoneal fat weight	3.2	10.4	14.1	3.3	2.4	2.6	-2.6	3.5	-3.8	3.7	-3.6
Reaction time number correct	0.5	0.8	1.8	1.2	1.3	0.8	-0.8	0.4	0.3	-0.6	0.9
Reaction time mean minus median	2.1	2.8	4.9	-2.2	-1.6	-1.7	1.7	-2.0	1.6	-1.4	1.0
Reaction time mean minus median AUC	2.0	2.6	4.5	-2.1	-1.8	-1.7	1.7	-1.9	1.3	-1.1	0.7
Reaction time num false alarms	0.4	0.5	1.9	-1.4	-0.7	-0.3	0.3	-0.7	0.5	-0.7	0.4
Reaction time num false alarms AUC	0.1	0.1	0.6	-0.8	-0.3	0.1	-0.1	-0.1	-0.1	-0.1	-0.1
Reaction time trials correct on left	0.5	0.8	1.8	1.2	1.3	0.8	-0.8	0.4	0.3	-0.6	0.9
Reaction time trials on left	0.5	0.7	1.7	1.2	1.3	0.8	-0.8	0.3	0.3	-0.7	0.9
Reaction time mean	2.4	3.4	8.5	-2.9	-2.6	-2.0	2.0	-1.7	0.5	-0.3	-0.5
Reaction time mean AUC	2.3	3.2	8.3	-2.9	-2.6	-1.9	1.9	-1.6	0.4	-0.2	-0.6
Median of all reaction times	2.0	2.8	6.9	-2.6	-2.5	-1.8	1.8	-1.2	-0.0	0.2	-1.1
Reaction time omissions	0.9	1.2	2.7	-1.6	-1.6	-0.9	0.9	-1.3	0.6	-0.5	0.1
Reaction time false alarm rate	0.2	0.3	1.3	-1.1	-0.7	-0.2	0.2	-0.1	-0.3	0.3	-0.5
Reaction time premature initiation rate	5.0	6.8	9.3	-2.8	-2.6	-2.7	2.7	-3.1	2.7	-2.4	1.6
Reaction time premature initiations	3.7	5.3	7.6	-2.0	-1.8	-2.1	2.1	-2.7	2.8	-2.7	2.0
Std. dev. reaction times	1.9	2.7	6.2	-2.5	-2.1	-1.7	1.7	-1.8	1.0	-0.9	0.4
Reaction time trials completed	0.5	0.7	1.7	1.2	1.3	0.8	-0.8	0.3	0.3	-0.7	0.9
Reaction time trials AUC	0.6	0.8	1.9	1.3	1.4	1.0	-1.0	0.5	0.1	-0.5	0.7
Run reversals in cocaine runway, females	0.9	0.8	1.8	-0.9	-1.4	-1.1	1.1	-1.0	0.6	-0.5	0.0
Run reversals in cocaine runway, males	1.0	1.0	1.6	1.2	1.1	1.3	-1.3	0.9	-0.6	0.7	-0.2
Latency to leave start box in cocaine runway	2.6	2.9	4.8	1.4	1.1	1.4	-1.4	1.7	-2.2	2.2	-1.9
Latency to leave start box in cocaine runway, F	3.8	4.2	7.5	1.4	1.1	1.8	-1.8	2.2	-2.6	2.7	-2.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	0.4	0.2	-0.3	0.3	-0.5	0.6	-0.8	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.1	-0.0	0.0	0.2	0.1
Total sessions with >9 infusions	0.1	0.1	0.3	-0.4	-0.2	0.1	-0.1	-0.5	0.4	0.3	-0.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.2	-0.4	0.3	-0.2	0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.9	-0.3	-0.3	-0.7	0.7	-0.1	0.4	-1.0	0.6
Short access day 1 total infusions	0.2	0.2	0.7	-0.3	-0.4	-0.5	0.5	-0.7	0.1	0.3	-0.8
Short access day 10 total infusions	1.2	1.3	3.3	-1.5	-1.2	-0.9	0.9	-1.8	1.2	-0.6	0.1
Short access total infusions	0.8	0.9	1.9	-1.4	-1.3	-0.9	0.9	-1.4	0.8	-0.1	-0.3
Short access day 1 locomotion	0.7	0.7	1.4	-1.2	-1.1	-0.8	0.8	-1.2	0.6	-0.1	0.1
Short access day 10 total locomotion	0.3	0.3	0.9	0.0	0.2	0.9	-0.9	0.1	-0.4	0.7	-0.4
Short access total locomotion	0.6	0.6	1.4	-1.1	-1.0	-0.5	0.5	-1.2	0.7	-0.0	0.1
One hour access (0.3 mA shock)	3.5	4.1	7.0	-2.6	-2.3	-2.0	2.0	-2.2	1.9	-1.5	1.4
Compulsive drug intake	0.8	0.8	1.9	-1.2	-1.4	-1.1	1.1	-0.8	0.2	-0.5	-0.2
One hour access (shock baseline)	0.8	1.0	1.6	-1.0	-0.7	-0.7	0.7	-1.1	1.3	-0.9	1.3
Social response proportion	0.8	0.9	3.0	0.1	0.1	0.0	-0.0	-0.5	1.1	-1.5	1.7
Social responses	0.9	1.2	2.4	-0.4	-0.5	-0.7	0.7	-1.1	1.4	-1.6	1.5
Social time	0.3	0.4	1.6	-0.6	-1.2	-0.8	0.8	-0.4	-0.1	-0.0	-0.3
Soleus weight	1.0	2.9	6.6	2.1	2.6	1.8	-1.8	1.7	-1.1	1.0	-0.6
Bone: stiffness	0.5	0.7	1.7	1.2	1.3	1.0	-1.0	0.8	-0.3	0.3	-0.0
Tibialis anterior weight	1.3	4.3	10.7	2.6	3.3	2.5	-2.5	1.8	-0.4	0.1	0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.5	-0.4	-0.2	0.2	0.1	-0.3	0.5	-0.2
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.2	0.9	1.1	0.9	-0.9	0.6	-0.4	0.1	-0.2
Time to tail flick, test, before self-admin	1.2	1.2	2.4	1.4	1.4	1.5	-1.5	0.9	-0.4	0.5	0.0
Time to tail flick, test, after self-admin	0.7	0.8	1.5	0.7	0.7	1.2	-1.2	0.7	-0.7	0.7	-0.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.5	1.2	1.0	0.9	-0.9	0.8	-0.8	0.5	-0.9
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.5	-0.6	-0.6	0.6	-0.4	0.2	-0.3	-0.2
Tibia length	2.0	5.7	11.8	3.2	3.4	2.8	-2.8	2.4	-1.2	0.8	0.5
Ambulatory time before self-admin	0.2	0.2	0.6	-0.0	-0.5	-0.1	0.1	0.2	-0.5	0.7	-0.7
Ambulatory time after self-admin	0.1	0.1	0.3	0.6	0.4	-0.0	0.0	-0.1	0.2	-0.3	0.2
Bone: tissue strength	1.0	1.0	2.0	0.8	1.3	1.4	-1.4	0.9	-0.6	0.2	-0.1
Total heroin consumption	1.2	1.4	2.7	-1.3	-1.5	-1.6	1.6	-0.9	-0.1	0.2	-0.9
Bone: trabecular number	4.4	7.0	13.0	3.6	3.6	3.1	-3.1	2.7	-1.4	1.3	-0.3
Bone: trabecular spacing	0.4	0.5	1.2	-1.0	-1.1	-0.6	0.6	-0.5	-0.3	0.4	-0.8
Bone: trabecular thickness	4.4	5.3	8.3	2.9	2.7	2.7	-2.7	2.5	-1.7	1.5	-0.9
Bone: trabecular tissue density	1.1	1.6	2.8	0.8	0.7	1.1	-1.1	1.2	-1.6	1.7	-1.4
Water consumed over 24 hours	0.7	0.8	2.6	0.4	0.8	-0.1	0.1	-0.3	1.0	-1.3	1.6
Number of responses in last shaping day	0.0	0.0	0.1	0.2	0.1	0.2	-0.2	-0.1	0.2	-0.2	0.3