Hub : Genes

LOC108352151

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression LOC108352151 0.23 0.09 0.0e+00 0.29 0.29 0.28 0.29 4.7e-32 1.9e-31 1.2e-30 2.2e-32
2 IL gene expression LOC108352151 0.24 0.12 1.6e-04 0.14 0.15 0.11 0.12 3.6e-04 2.3e-04 1.3e-03 6.9e-04
3 IC gene expression LOC108352151 0.16 0.08 6.6e-06 0.09 0.06 0.07 0.07 1.9e-04 1.4e-03 9.4e-04 4.8e-04
4 Brain gene expression LOC108352151 0.04 0.02 7.2e-06 0.04 0.06 0.04 0.05 1.9e-04 4.6e-06 5.1e-05 3.6e-05
5 BLA gene expression LOC108352151 0.39 0.14 3.5e-13 0.19 0.14 0.18 0.2 3.5e-10 4.4e-08 5.7e-10 9.3e-11
6 NAcc intron excision ratio chr10_93282648_93283659 0.03 0.01 2.5e-06 0.03 0.04 0.03 0.03 5.1e-05 2.5e-06 7.5e-05 1.0e-05
7 PL intron excision ratio chr10_93282648_93283659 0.02 0.01 4.9e-03 0.04 0.02 0.02 0.02 9.5e-05 4.1e-03 2.2e-03 1.2e-03
8 PL intron excision ratio chr10_93282893_93283659 0.03 0.02 1.6e-03 0.02 0.02 0.02 0.02 2.5e-03 2.3e-03 3.3e-03 3.5e-03
9 NAcc intron excision ratio chr10_93282893_93283659 0.01 0.01 4.0e-03 0.01 0.01 0.01 0.01 2.7e-03 1.9e-03 8.1e-03 5.1e-03
10 pVTA gene expression LOC108352151 0.04 0.02 1.9e-04 0.04 0.05 0.03 0.04 2.1e-04 9.3e-05 1.1e-03 5.5e-04
11 BLA intron excision ratio chr10_93263670_93282683 0.07 0.05 7.9e-04 0.05 0.04 0.04 0.05 9.8e-04 2.0e-03 5.4e-03 1.8e-03
12 BLA intron excision ratio chr10_93282648_93283659 0.08 0.06 7.6e-03 -0 0.01 -0 -0 8.3e-01 1.1e-01 6.0e-01 8.2e-01
13 BLA intron excision ratio chr10_93282893_93283659 0.08 0.06 7.4e-03 -0 0.01 -0 -0 8.3e-01 1.1e-01 6.0e-01 8.1e-01
14 NAcc gene expression LOC108352151 0.09 0.05 5.5e-15 0.09 0.1 0.1 0.1 4.4e-14 1.1e-14 1.5e-15 6.8e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.51.1-0.5-0.20.4-0.8-0.5-0.70.80.40.9-0.7-0.7-1.01.01.0
Area under the delay curve0.30.41.10.71.1-1.00.30.80.50.4-0.6-0.10.40.1-0.70.7-0.4
BMI with tail0.41.46.9-0.40.10.50.1-0.4-1.60.82.60.7-1.2-0.3-0.40.4-2.6
BMI without tail0.73.513.5-1.4-0.71.6-0.8-1.5-2.61.83.71.6-2.2-1.5-1.11.1-2.3
Body weight1.98.218.3-2.6-1.92.4-2.3-2.6-3.53.04.33.1-3.3-2.8-3.13.0-1.0
Weight adjusted by age1.02.94.91.71.8-2.21.62.01.8-1.5-1.6-1.61.92.01.1-1.1-1.6
Bone surface3.06.08.6-2.7-2.52.6-2.9-2.5-2.42.51.92.7-2.3-2.1-2.32.32.4
Bone volume2.04.05.6-2.0-1.71.9-2.4-1.9-2.02.21.62.3-1.9-1.7-2.32.31.8
Breakpoint value in progressive ratio session1.32.44.61.31.0-1.11.51.31.5-1.1-1.3-1.91.71.72.1-2.1-1.3
Number of licking bursts0.00.10.4-0.5-0.50.6-0.3-0.6-0.10.10.10.2-0.2-0.2-0.10.10.2
Context. condit. distance diff. score0.10.11.00.40.3-0.30.20.20.2-0.1-0.1-0.10.2-0.3-0.10.1-1.0
Locomotion velocity, session 10.20.20.6-0.5-0.50.8-0.5-0.6-0.40.40.30.4-0.3-0.1-0.10.1-0.1
Locomotion distance, session 10.10.10.9-0.1-0.00.2-0.1-0.1-0.0-0.00.0-0.00.10.40.2-0.2-0.9
Locomotion velocity, session 20.50.62.4-1.1-1.51.3-0.8-1.0-0.50.10.40.1-0.3-0.10.8-0.80.3
Locomotion distance, session 20.20.20.9-0.3-0.40.30.0-0.10.1-0.2-0.1-0.50.30.50.9-0.9-0.7
Locomotion velocity, session 32.22.64.91.51.4-1.61.61.61.5-1.7-1.4-1.71.61.31.6-1.6-2.2
Locomotion distance, session 30.30.30.70.50.4-0.60.30.50.7-0.8-0.9-0.50.70.30.3-0.3-0.6
Stereotopy head waving bouts, day 32.32.74.02.02.0-1.81.71.81.6-1.5-1.6-1.51.61.71.3-1.3-1.3
Stereotopy head waving duration, day 32.02.53.71.91.9-1.81.61.81.6-1.3-1.7-1.41.61.71.0-1.0-1.4
Locomotion velocity, session 70.50.51.30.70.5-0.40.70.50.5-0.7-0.4-0.80.70.71.1-1.1-0.6
Locomotion distance, session 70.10.10.2-0.2-0.20.2-0.2-0.3-0.20.20.20.3-0.3-0.5-0.40.4-0.3
Stereotopy head waving bouts, day 72.83.24.11.71.4-1.91.71.81.9-1.9-1.8-2.01.91.52.0-2.0-1.4
Stereotopy head waving duration, day 74.04.96.62.01.6-2.32.12.22.4-2.4-2.4-2.52.42.12.6-2.6-1.1
Locomotion velocity, session 80.10.10.4-0.4-0.60.6-0.4-0.4-0.2-0.00.10.2-0.1-0.00.2-0.20.6
Locomotion distance, session 80.10.10.4-0.4-0.60.5-0.4-0.6-0.30.40.30.1-0.2-0.40.2-0.2-0.4
Degree of sensitization distance0.50.50.8-0.6-0.60.7-0.6-0.7-0.80.90.90.8-0.9-0.7-0.70.70.1
Degree of sensitization stereotypy2.22.54.81.20.8-1.51.51.41.6-1.7-1.4-1.91.61.22.2-2.2-1.4
Conditioned locomotion0.00.00.2-0.1-0.00.0-0.1-0.0-0.20.10.20.2-0.10.4-0.00.00.2
Cocaine response after cond. corrected0.10.20.50.50.3-0.60.20.60.6-0.5-0.7-0.30.4-0.2-0.10.1-0.0
Cocaine response after cond. not corrected0.30.41.30.5-0.1-0.60.30.61.0-0.9-1.1-0.70.80.10.6-0.60.2
Cocaine response before conditioning0.30.30.90.1-0.3-0.00.10.20.6-0.6-0.8-0.60.70.40.9-0.9-0.2
Saline control response0.50.62.7-0.7-0.70.7-0.2-0.7-1.10.81.70.4-0.9-0.7-0.00.0-0.9
Bone: connectivity density0.61.02.2-1.0-0.80.9-1.1-1.0-1.01.10.61.1-0.9-0.7-0.90.91.5
Bone: cortical apparent density2.94.69.82.83.1-2.62.62.41.9-1.8-1.4-1.91.71.51.2-1.1-2.5
Bone: cortical area0.71.22.5-1.0-0.90.8-1.0-0.8-1.41.41.61.2-1.3-1.1-1.01.0-0.4
Bone: cortical porosity3.23.57.8-2.5-2.82.4-2.2-2.2-1.81.71.51.6-1.6-1.3-0.70.71.8
Bone: cortical porosity2.32.64.9-2.1-2.21.9-1.9-1.8-1.61.71.51.5-1.5-1.2-1.01.00.9
Bone: cortical thickness4.57.617.73.13.2-3.23.33.12.1-2.3-1.3-2.82.21.92.4-2.4-4.2
Bone: cortical thickness1.31.66.31.21.2-1.21.61.20.6-0.8-0.1-1.20.70.91.4-1.4-2.5
Bone: cortical tissue density2.84.59.52.83.1-2.62.62.41.8-1.8-1.4-1.91.71.61.2-1.2-2.5
Condit. Reinf. active minus inactive responses2.93.35.1-2.1-2.31.9-2.2-2.0-1.52.11.41.8-1.6-1.9-1.81.70.1
Condit. Reinf. active-inactive response ratio0.91.01.6-1.1-1.21.1-1.3-1.0-0.71.30.41.0-0.8-0.9-1.01.00.2
Condit. Reinf. active responses3.03.96.1-2.2-2.52.0-2.4-2.1-1.82.21.72.0-1.8-2.1-1.81.80.3
Condit. Reinf. inactive responses0.91.11.7-1.1-1.20.8-1.3-1.1-1.11.01.21.1-1.1-1.2-1.01.00.2
Incentive salience index mean1.62.13.8-1.7-2.01.6-1.7-1.6-1.31.71.31.3-1.3-1.4-1.11.10.2
Condit. Reinf. lever presses0.10.10.4-0.3-0.60.1-0.1-0.2-0.20.10.4-0.20.0-0.20.6-0.7-0.2
Condit. Reinf. active minus inactive responses4.26.410.0-3.0-3.22.7-3.0-2.9-2.32.62.02.5-2.4-2.9-2.22.10.8
Condit. Reinf. active-inactive response ratio2.23.56.1-2.3-2.52.1-2.2-2.1-1.61.91.31.7-1.7-2.2-1.51.51.0
Condit. Reinf. active responses6.28.912.9-3.4-3.63.3-3.4-3.3-2.93.12.62.9-2.9-3.3-2.52.51.3
Condit. Reinf. inactive responses2.02.93.8-1.8-1.82.0-1.8-1.8-1.91.81.91.7-1.8-1.7-1.31.30.6
Condit. Reinf. lever presses4.26.19.2-2.9-3.02.7-2.6-2.8-2.52.72.52.2-2.5-2.8-1.71.70.8
Condit. Reinf. lever reinforcers received6.38.812.4-3.3-3.53.2-3.4-3.3-2.93.22.62.9-2.9-3.4-2.52.51.5
Conditioned reinforcement - actives0.31.12.3-1.3-1.11.5-0.9-1.4-1.11.11.00.9-1.2-0.9-0.60.60.3
Conditioned reinforcement - inactives0.30.81.5-0.9-0.91.2-0.8-1.2-1.00.81.10.9-0.9-0.8-0.70.7-0.3
Conditioned locomotion2.33.44.7-1.9-1.62.1-1.7-2.1-2.21.32.12.0-2.1-1.9-1.71.70.4
Patch foraging indifference point 0 sec3.710.414.4-3.1-2.73.0-3.2-3.2-3.53.33.63.4-3.5-3.8-3.53.50.5
Patch foraging indifference point AUC0.30.82.2-0.8-0.81.0-0.8-1.0-0.91.50.90.8-0.9-1.0-0.60.60.4
Delay disc. indifference point, 0s delay0.91.01.91.21.2-1.41.01.21.2-0.6-1.2-0.91.11.10.5-0.50.1
Delay disc. indifference point, 16s delay0.20.31.30.20.6-0.50.10.1-0.01.10.10.3-0.2-0.4-0.91.0-0.3
Delay disc. indifference point, 2s delay0.40.52.1-0.00.30.2-0.7-0.0-0.30.60.10.9-0.4-0.3-1.41.50.6
Delay disc. indifference point, 24s delay0.71.22.9-0.50.00.7-0.7-0.7-1.11.51.21.2-1.2-1.1-1.71.7-0.3
Delay disc. indifference point, 4s delay1.01.12.11.00.9-1.40.91.31.3-0.6-1.4-1.01.21.10.7-0.7-0.5
Delay disc. indifference point, 8s delay0.71.23.21.51.8-1.61.11.51.1-0.5-1.0-0.71.00.7-0.10.1-0.9
Indifference point function ln k0.20.72.40.80.7-1.00.60.90.6-1.0-0.6-0.60.70.60.5-0.5-1.6
Indifference point function log k0.20.72.40.80.7-1.00.60.90.6-1.0-0.6-0.60.70.60.5-0.5-1.6
Patch foraging total patch changes 0 sec3.410.014.1-3.0-2.73.0-3.1-3.2-3.43.33.53.3-3.5-3.8-3.43.40.8
Patch foraging total patch changes 12 sec6.58.711.4-2.9-2.63.0-3.0-3.1-3.03.43.03.1-3.1-3.2-3.03.01.5
Patch foraging total patch changes 18 sec1.02.43.9-1.5-1.51.4-1.4-1.5-1.82.01.91.5-1.7-1.9-1.21.2-0.2
Patch foraging total patch changes 24 sec1.34.57.8-1.8-1.62.1-2.0-2.2-2.32.82.32.2-2.2-2.7-2.12.10.2
Patch foraging total patch changes 6 sec5.28.813.2-2.9-2.72.9-2.9-3.2-3.13.03.23.0-3.1-3.6-3.03.01.0
Patch foraging time to switch 0 sec0.10.40.70.70.7-0.80.80.70.7-0.8-0.7-0.70.70.50.5-0.5-0.4
Patch foraging water rate 0 sec0.93.55.1-1.8-1.61.9-1.9-2.0-2.21.62.32.0-2.1-1.9-1.81.80.6
Patch foraging water rate 12 sec0.00.10.60.20.3-0.10.30.20.1-0.20.0-0.30.20.30.3-0.3-0.8
Patch foraging water rate 18 sec0.00.10.5-0.10.10.2-0.1-0.1-0.2-0.20.40.1-0.20.0-0.20.2-0.7
Patch foraging water rate 24 sec0.30.41.10.70.7-0.40.40.60.7-1.0-0.8-0.50.80.90.4-0.4-0.5
Patch foraging water rate 6 sec0.20.31.10.60.6-0.80.50.70.2-0.3-0.0-0.40.30.30.3-0.3-1.1
Seeking ratio, delayed vs. immediate footshock0.10.21.20.40.6-0.50.40.40.1-0.40.0-0.10.10.3-0.10.1-1.1
Distance traveled before self-admin0.61.42.90.90.8-1.00.90.91.4-1.6-1.7-1.21.41.31.1-1.1-0.5
Distance traveled after self-admin0.10.10.4-0.6-0.60.3-0.4-0.50.2-0.4-0.4-0.10.1-0.20.2-0.30.3
Extensor digitorum longus weight1.24.97.82.52.8-2.62.82.61.7-2.2-1.1-2.12.02.72.0-2.0-0.8
Bone: elastic displacement1.41.82.71.31.0-1.21.31.21.3-1.4-1.2-1.51.31.11.5-1.5-1.6
Bone: elastic work0.10.10.60.20.2-0.10.20.1-0.4-0.30.70.0-0.2-0.10.2-0.2-0.8
Bone: endosteal estimation14.635.846.9-6.7-6.86.5-6.8-6.3-5.96.15.06.3-5.7-5.1-5.35.35.5
Bone: endosteal perimeter11.929.339.4-5.9-5.85.7-6.3-5.6-5.25.54.45.9-5.1-4.6-5.35.35.0
Epididymis fat weight0.10.62.8-0.5-0.10.5-0.2-0.4-1.10.71.70.7-1.0-0.4-0.90.9-0.7
Delta time in closed arm before/after self-admin0.20.20.50.60.4-0.60.20.60.4-0.7-0.5-0.20.30.50.1-0.10.5
Delta time in open arm before/after self-admin0.40.50.90.81.0-0.90.80.90.8-0.5-0.8-0.70.70.60.4-0.4-0.8
Diff in mean of infusions in LGA sessions1.22.23.51.31.4-1.41.81.41.3-1.1-0.9-1.71.41.61.9-1.9-1.3
Delay discount exponential model param0.20.30.9-0.5-0.80.7-0.0-0.5-0.3-0.60.3-0.2-0.10.20.9-0.90.1
Extinction: sum of active levers before priming0.50.71.31.10.9-1.10.91.00.7-0.3-0.5-0.80.80.80.9-0.9-0.7
Active lever presses in extinction session 61.01.02.0-1.1-0.91.4-0.9-1.3-1.01.31.00.9-1.0-0.8-0.60.60.8
Bone: final force1.32.12.9-1.3-1.11.3-1.5-1.3-1.61.61.51.6-1.5-1.7-1.71.60.5
Bone: final moment1.42.33.2-1.4-1.21.3-1.6-1.3-1.61.71.61.7-1.6-1.8-1.71.70.6
Food consumed during 24 hour testing period0.61.34.2-1.0-0.80.9-0.6-1.0-1.71.42.11.0-1.5-1.0-0.60.6-0.2
Glucose2.23.56.11.71.7-1.41.91.82.0-1.9-1.9-2.02.12.51.9-1.9-1.3
Heart weight0.30.51.40.70.8-1.20.80.80.7-0.2-0.6-0.60.60.40.2-0.2-1.0
Delay discount hyperbolic model param0.20.30.7-0.6-0.80.7-0.1-0.6-0.3-0.40.4-0.1-0.20.00.8-0.90.2
Intermittent access intake day 1-15 change0.10.51.3-0.8-1.00.8-0.6-0.7-0.50.70.50.5-0.5-0.7-0.20.21.1
Intermittent access intake escalation0.10.71.3-0.9-1.11.0-0.8-0.9-0.70.80.70.7-0.7-0.9-0.50.50.9
Intermittent access intake escalation 20.91.62.8-1.4-1.71.5-1.2-1.4-1.21.01.11.1-1.2-1.5-0.60.61.6
Intermitt. access day 1 inactive lever presses0.10.81.6-1.0-1.31.0-0.9-1.1-1.01.01.30.7-0.8-1.1-0.30.3-0.3
Intermitt. access day 15 inactive lever presses0.10.61.7-0.6-0.70.8-0.5-0.8-1.01.01.30.7-0.9-0.8-0.30.30.3
Intermitt. access escalation Index0.20.71.50.40.3-0.70.80.61.1-0.5-1.2-1.11.00.71.1-1.10.5
Intermittent access day 1 total infusions0.20.61.4-0.8-0.80.8-0.8-0.9-0.80.80.80.7-0.7-0.7-0.60.6-1.2
Intermittent access day 15 total infusions0.92.33.5-1.5-1.61.5-1.5-1.7-1.51.91.61.5-1.5-1.7-1.41.4-0.0
Intermittent access terminal intake (last 3 days)2.95.17.1-2.3-2.32.2-2.3-2.4-2.32.72.22.3-2.3-2.6-2.22.11.1
Intermittent access total infusions3.13.74.9-1.9-1.91.9-2.0-2.0-2.02.21.92.0-2.0-2.2-2.02.0-0.2
Intermittent access day 1 locomotion1.73.25.1-1.8-1.71.9-1.7-2.0-2.01.72.31.8-1.9-1.7-1.61.6-0.9
Intermittent access day 15 total locomotion1.86.99.3-2.7-2.62.8-2.6-2.8-2.92.83.12.7-2.8-2.7-2.42.40.0
Intermittent access total locomotion8.29.814.4-3.1-3.03.3-3.1-3.3-3.63.33.83.3-3.4-3.2-2.92.9-0.3
Intermittent access standard deviation0.20.91.3-0.8-0.91.1-1.0-0.9-0.90.70.91.1-0.9-1.1-1.11.10.6
Left kidney weight0.00.22.0-0.00.00.10.2-0.1-0.00.00.3-0.20.10.10.1-0.1-1.4
Right kidney weight0.00.21.50.20.3-0.40.30.30.00.30.3-0.20.10.0-0.10.1-1.2
Cocaine induced anxiety0.00.10.4-0.00.00.30.00.00.4-0.2-0.6-0.20.40.60.3-0.30.2
Post-drug Anxiety0.80.92.11.01.1-0.30.80.71.0-1.2-1.1-0.91.11.50.8-0.8-0.2
Baseline Anxiety0.40.71.91.11.4-0.71.20.60.6-1.1-0.4-0.80.50.70.7-0.7-0.4
Tail length1.68.811.5-3.0-2.83.2-2.9-3.2-3.33.23.43.0-3.2-3.2-2.62.61.2
Length with tail1.77.710.6-2.8-2.52.5-3.0-2.7-2.72.82.63.1-2.8-3.0-3.33.31.5
Length without tail0.10.72.7-0.5-0.3-0.1-0.8-0.3-0.60.80.51.0-0.8-1.1-1.61.60.3
Times rat made contact with spout0.70.71.7-1.1-1.31.0-0.9-1.0-0.90.91.00.7-0.9-0.8-0.20.2-0.3
Lifetime Intake2.53.14.0-1.7-1.61.7-1.7-1.8-1.91.92.01.8-1.8-2.0-1.71.7-0.8
Liver weight, left2.03.56.3-2.4-2.52.3-2.3-2.2-1.91.71.71.8-1.7-1.6-1.21.21.1
Liver weight, right0.40.83.70.30.3-0.50.90.40.5-0.7-0.2-1.00.60.71.2-1.3-1.9
Locomotor activity1.52.44.2-1.9-1.81.8-1.3-1.8-1.72.01.91.1-1.5-1.6-0.60.6-0.9
Locomotor testing distance0.51.22.1-1.4-1.41.3-0.9-1.3-1.21.31.40.6-1.0-1.0-0.00.0-1.1
Locomotor testing rearing0.31.13.4-1.3-1.81.3-0.7-1.1-1.01.11.30.1-0.6-0.51.0-1.00.1
Locomotion in novel chamber0.60.81.41.10.8-1.00.61.11.2-0.4-1.2-0.81.21.20.5-0.50.1
Locomotion in novel chamber post-restriction0.41.13.5-0.7-0.60.7-1.4-0.9-0.8-0.10.61.4-0.9-0.6-1.91.90.9
Fecal boli incidents, locomotor time 10.10.31.00.50.6-0.50.30.70.60.4-0.7-0.20.51.0-0.20.20.3
Change in fecal boli incidents, locomotor task0.60.71.8-0.5-0.40.6-0.7-0.7-0.80.80.60.9-1.0-1.3-1.01.00.3
Time >=10cm from walls, locomotor time 11.11.42.41.00.6-0.90.91.01.4-1.6-1.5-1.31.41.01.2-1.2-1.1
Bouts of movement, locomotor time 10.10.20.50.60.7-0.70.60.50.1-0.30.3-0.30.20.30.1-0.1-0.3
Total resting periods, locomotor time 10.20.20.70.70.8-0.80.60.70.2-0.30.1-0.30.20.50.1-0.1-0.1
Rest time, locomotor task time 10.81.32.51.21.1-1.61.01.51.1-1.1-1.1-0.91.21.40.8-0.8-0.1
Distance moved, locomotor task time 10.10.20.6-0.4-0.20.7-0.1-0.6-0.6-0.10.80.3-0.5-0.4-0.10.1-0.4
Vertical activity count, locomotor time 10.00.20.6-0.3-0.20.5-0.2-0.7-0.4-0.30.50.3-0.4-0.8-0.20.2-0.6
Time >=10cm from walls, locomotor time 20.51.44.30.70.3-0.91.11.00.9-1.1-0.6-1.51.21.32.1-2.1-0.4
Bouts of movement, locomotor time 20.30.92.01.11.3-1.31.41.00.6-0.3-0.0-1.00.70.70.9-0.9-1.0
Total resting periods, locomotor time 20.31.22.21.31.4-1.51.51.20.9-0.6-0.4-1.20.90.80.9-0.9-1.2
Rest time, locomotor task time 24.37.310.83.12.9-3.12.63.03.1-2.4-3.3-2.52.92.61.8-1.8-1.9
Distance moved, locomotor task time 20.40.61.7-0.9-0.91.0-0.2-0.7-0.90.31.30.0-0.60.10.9-0.90.6
Vertical activity count, locomotor time 21.22.86.2-2.1-2.11.9-1.4-2.1-2.11.32.51.3-1.9-1.6-0.40.30.6
Light reinforcement 10.20.85.80.91.2-0.80.90.5-0.0-0.40.6-0.40.0-0.30.0-0.0-2.4
Light reinforcement 20.61.47.21.61.9-1.31.01.00.8-1.0-0.5-0.50.70.3-0.30.3-2.7
Bone: marrow area14.134.545.3-6.6-6.76.4-6.7-6.2-5.85.94.96.2-5.6-5.0-5.25.15.5
Bone: maximum diameter3.97.911.3-2.9-2.82.8-3.4-2.7-2.72.92.23.2-2.7-2.3-3.13.12.3
Bone: maximum force1.83.55.3-1.7-1.41.7-2.0-1.6-2.12.02.02.2-2.0-1.9-2.32.30.2
Bone: maximum moment2.13.95.6-1.8-1.51.7-2.1-1.7-2.22.12.12.3-2.1-2.1-2.42.40.3
Mean time between licks in bursts0.00.20.80.10.30.4-0.1-0.1-0.40.50.50.6-0.4-0.2-0.90.9-0.2
Mean num. licks in bursts0.00.10.60.10.1-0.2-0.00.2-0.30.30.40.2-0.3-0.2-0.10.1-0.8
Cd content in liver0.91.02.11.10.9-1.00.81.11.2-1.4-1.4-0.81.10.90.6-0.60.9
Co content in liver1.41.72.31.51.5-1.51.31.41.5-1.4-1.4-1.21.41.20.8-0.8-1.1
Cu content in liver0.20.20.6-0.4-0.50.4-0.5-0.5-0.30.30.30.4-0.4-0.8-0.40.40.8
Fe content in liver0.20.31.1-0.7-1.00.7-0.8-0.7-0.20.20.10.3-0.2-0.8-0.00.00.2
K content in liver0.10.10.40.30.2-0.3-0.30.10.20.0-0.40.20.0-0.6-0.60.7-0.3
Mg content in liver0.20.20.50.60.6-0.70.30.50.5-0.5-0.7-0.30.3-0.2-0.10.10.1
Mn content in liver0.10.10.3-0.2-0.10.1-0.5-0.2-0.10.5-0.30.4-0.2-0.3-0.60.60.5
Na content in liver0.20.30.90.60.5-0.60.30.50.8-0.4-0.9-0.50.70.30.1-0.1-0.7
Rb content in liver0.40.41.60.60.5-0.60.40.61.0-0.5-1.3-0.60.80.40.3-0.30.1
Se content in liver1.92.24.71.71.7-1.61.31.51.8-1.2-1.8-1.41.61.20.7-0.7-2.2
Sr content in liver0.10.10.3-0.2-0.00.3-0.0-0.2-0.40.30.50.2-0.30.1-0.00.0-0.4
Zn content in liver0.50.61.70.80.5-0.80.60.71.2-0.8-1.3-0.91.00.20.6-0.6-0.4
Bone: minimum diameter11.622.226.9-4.9-4.64.5-5.1-4.6-4.95.04.55.2-4.8-4.4-4.84.83.7
Time in familiar zone, hab. session 11.71.84.1-1.2-1.11.1-1.3-1.2-1.21.61.11.4-1.3-1.3-1.41.42.0
Time in novel zone, hab. session 10.70.81.90.60.6-0.61.00.60.7-1.0-0.5-1.10.70.81.2-1.2-1.4
Total zone transitions, hab. session 10.20.31.0-0.6-0.30.7-0.3-0.6-0.80.71.00.4-0.5-0.10.0-0.0-0.5
Total locomotion distance, hab. session 10.81.12.6-1.1-0.91.3-0.8-1.2-1.41.31.60.9-1.1-0.7-0.40.4-0.7
Locomotion velocity, hab. session 10.60.82.0-0.9-0.81.1-0.8-1.0-1.21.21.40.8-0.9-0.5-0.40.4-0.7
Time in familiar zone, hab. session 21.21.32.4-1.3-1.61.4-1.3-1.3-1.01.01.01.0-1.0-1.4-0.60.61.2
Time in novel zone, hab. session 20.50.61.40.81.2-0.90.80.90.7-0.6-0.7-0.60.61.00.2-0.2-0.7
Total zone transitions, hab. session 20.20.20.9-0.1-0.00.20.4-0.1-0.1-0.10.5-0.40.10.50.9-0.9-0.6
Total locomotion distance, hab. session 20.30.41.5-0.5-0.20.6-0.2-0.6-0.90.91.20.4-0.6-0.20.0-0.0-0.5
Locomotion velocity, hab. session 20.10.20.9-0.30.00.40.0-0.3-0.60.61.00.1-0.40.00.2-0.2-0.5
Novel to familiar place preference ratio1.82.33.1-1.5-1.21.5-1.5-1.6-1.61.41.51.7-1.5-1.6-1.81.70.9
Novelty place preference1.11.41.8-1.2-1.01.2-1.2-1.3-1.21.01.11.3-1.2-1.2-1.31.30.7
Time in novel zone, NPP test1.01.31.7-1.2-1.11.2-1.2-1.3-1.20.91.11.2-1.1-1.3-1.11.10.5
Total zone transitions, NPP test0.20.22.30.10.2-0.00.30.1-0.1-0.10.3-0.30.10.40.5-0.5-1.5
Total locomotion distance, NPP test0.50.71.7-0.9-0.90.9-0.7-1.1-1.11.01.30.6-0.9-0.9-0.20.2-0.5
Locomotion velocity, NPP test0.20.31.0-0.3-0.10.3-0.2-0.5-0.70.51.00.3-0.5-0.5-0.20.2-1.0
Intraocular pressure0.10.21.7-0.3-0.10.30.1-0.3-0.10.30.1-0.1-0.1-0.20.1-0.1-1.3
Delta distance traveled before/after self-admin0.60.71.1-1.1-1.10.8-0.6-1.0-0.91.01.00.6-0.9-1.1-0.20.20.2
Delta ambulatory time before/after self-admin1.12.03.5-1.6-1.51.3-1.3-1.6-1.51.91.41.3-1.5-1.6-1.01.01.0
Parametrial fat weight0.30.74.2-0.3-0.20.3-0.7-0.4-0.40.30.10.9-0.6-0.8-1.21.22.0
Pavlov. Cond. lever latency0.40.41.80.70.9-0.40.30.60.6-0.5-0.9-0.10.40.8-0.40.41.3
Pavlov. Cond. magazine entry latency1.82.44.4-1.6-1.71.5-1.7-1.5-1.51.71.51.5-1.5-2.1-1.41.4-0.6
Pavlov. Cond. change in total contacts1.41.52.8-1.4-1.71.2-1.2-1.3-1.21.31.40.9-1.1-1.6-0.50.5-0.9
Pavlov. Cond. index score1.21.53.3-1.3-1.41.1-1.2-1.2-1.21.41.31.0-1.1-1.8-0.80.8-1.1
Pavlov. Cond. latency score0.81.02.4-1.0-1.20.8-0.9-0.9-0.91.01.10.7-0.9-1.6-0.50.5-1.3
Pavlov. Cond. lever contacts0.30.41.3-0.6-0.80.5-0.3-0.5-0.60.40.90.1-0.3-0.80.4-0.4-1.1
Pavlov. Cond. magazine entry number1.31.63.41.31.3-1.01.41.21.1-1.4-1.0-1.21.21.81.4-1.30.8
Pavlov. Cond. intertrial magazine entries1.82.24.4-1.2-0.91.3-1.5-1.4-1.51.51.41.8-1.5-1.3-2.12.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.11.42.8-1.2-1.41.0-1.2-1.1-1.11.31.21.0-1.1-1.7-0.80.8-1.1
Pavlov. Cond. response bias1.62.03.2-1.5-1.61.4-1.6-1.4-1.41.71.41.3-1.3-1.8-1.11.1-0.7
Pavlov. Cond. lever latency0.91.22.21.31.5-1.11.31.21.0-1.3-0.8-1.01.11.50.8-0.8-0.2
Pavlov. Cond. magazine entry latency1.52.23.41.51.2-1.81.41.61.8-1.5-1.8-1.61.61.21.2-1.2-1.0
Pavlov. Cond. change in total contacts0.20.51.6-0.9-1.30.6-1.0-0.7-0.40.60.20.5-0.5-1.0-0.30.30.4
Pavlov. Cond. index score0.10.20.8-0.6-0.90.3-0.5-0.5-0.10.4-0.10.2-0.2-0.7-0.10.1-0.0
Pavlov. Cond. latency score0.10.10.6-0.4-0.70.1-0.3-0.20.20.2-0.4-0.10.1-0.50.1-0.1-0.2
Pavlov. Cond. lever contacts0.60.91.8-1.1-1.30.9-1.0-1.1-0.91.20.80.8-1.0-1.3-0.60.6-0.0
Pavlov. Cond. magazine entry number2.53.34.9-1.8-1.42.0-1.7-1.9-2.21.92.22.0-2.0-1.4-1.61.61.4
Pavlov. Cond. intertrial magazine entries5.010.814.4-3.2-2.73.4-3.1-3.4-3.83.43.83.5-3.6-3.2-2.92.92.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.5-0.80.2-0.4-0.30.10.3-0.30.1-0.0-0.6-0.00.0-0.1
Pavlov. Cond. response bias0.30.40.9-0.7-0.90.5-0.7-0.6-0.50.70.30.5-0.5-1.0-0.40.4-0.2
Time in closed arm before self-admin0.50.82.1-1.2-1.10.9-0.5-1.0-0.81.51.00.3-0.8-1.2-0.00.00.2
Time in closed arm after self-admin0.10.10.4-0.3-0.50.1-0.0-0.1-0.00.20.2-0.2-0.0-0.10.5-0.50.7
Time in open arm before self-admin1.11.31.81.21.0-1.01.21.11.3-1.1-1.2-1.21.31.41.0-1.0-1.1
Time in open arm after self-admin0.80.91.81.01.1-1.10.81.01.0-1.0-1.1-0.61.00.80.2-0.2-1.3
Bone: periosteal estimation9.121.727.3-5.1-5.04.8-5.2-4.7-4.85.04.35.0-4.7-4.1-4.34.33.3
Bone: periosteal perimeter3.16.28.9-2.6-2.62.4-3.0-2.4-2.42.62.02.8-2.3-2.2-2.72.71.7
Bone: post-yield work1.42.53.2-1.7-1.51.5-1.8-1.4-1.71.61.51.8-1.6-1.0-1.71.71.4
Progressive ratio test 1 active lever presses2.34.06.8-2.1-1.92.0-1.8-2.0-2.32.62.51.9-2.2-1.9-1.61.6-0.4
Progressive ratio test 1 breakpoint2.64.57.6-2.3-2.02.0-1.9-2.2-2.52.82.72.1-2.4-2.0-1.81.8-0.2
Progressive ratio test 1 inactive lever presses1.94.97.6-2.4-2.32.4-2.2-2.5-2.52.42.72.1-2.4-2.2-1.71.7-0.0
Progressive ratio test 2 active lever presses1.41.92.9-1.4-1.31.1-1.6-1.3-1.41.21.41.5-1.4-1.3-1.71.7-0.9
Progressive ratio test 2 breakpoint1.72.23.2-1.5-1.41.2-1.7-1.4-1.51.31.51.7-1.5-1.4-1.81.8-0.8
Progressive ratio test 2 inactive lever presses0.61.83.0-0.9-0.60.9-1.2-1.1-1.51.51.71.5-1.4-1.2-1.71.7-1.1
Incentive Sensitization - Responses0.10.21.80.20.1-0.2-0.30.20.1-0.5-0.30.20.20.4-0.40.4-1.3
Incentive Sensitization - Breakpoint0.10.21.50.1-0.0-0.1-0.40.20.1-0.5-0.30.20.20.4-0.40.4-1.2
Sum of active levers in priming session hrs 5-60.60.51.50.40.4-0.30.80.30.7-0.0-0.7-1.00.80.71.2-1.2-0.4
Progressive ratio0.20.71.51.11.1-1.00.41.01.0-0.5-1.2-0.31.00.9-0.40.4-0.5
Food seeking constrained by brief footshock2.93.66.9-2.5-2.62.6-2.0-2.3-1.91.81.61.7-1.8-1.3-0.70.71.9
Seeking ratio, punishment vs. effort1.32.85.3-2.2-2.32.2-1.5-2.0-1.91.42.01.3-1.8-1.4-0.20.21.1
Retroperitoneal fat weight0.21.04.5-0.6-0.41.1-0.4-0.8-1.40.52.10.9-1.3-0.7-0.80.7-0.4
Reaction time number correct0.30.91.71.01.1-1.30.71.21.0-1.0-1.2-0.70.91.10.1-0.1-1.0
Reaction time mean minus median0.00.21.40.10.4-0.30.40.40.10.1-0.2-0.10.20.50.2-0.21.2
Reaction time mean minus median AUC0.00.10.9-0.00.3-0.20.10.20.10.5-0.30.2-0.00.2-0.40.41.0
Reaction time num false alarms1.01.72.8-1.7-1.71.3-1.7-1.2-1.31.01.31.3-1.2-0.9-1.21.2-0.8
Reaction time num false alarms AUC1.12.64.1-2.0-1.91.7-2.0-1.6-1.71.31.61.7-1.6-1.3-1.61.6-0.3
Reaction time trials correct on left0.30.91.71.01.1-1.30.71.21.0-1.0-1.2-0.70.91.10.1-0.1-1.0
Reaction time trials on left0.20.81.51.01.1-1.20.61.11.0-0.9-1.1-0.60.91.00.0-0.0-1.0
Reaction time mean0.00.10.40.0-0.00.0-0.00.10.40.2-0.7-0.10.30.2-0.00.00.6
Reaction time mean AUC0.00.10.40.0-0.00.10.10.20.50.1-0.7-0.30.30.40.3-0.30.6
Median of all reaction times0.00.10.4-0.0-0.20.2-0.10.00.40.2-0.7-0.10.20.2-0.00.00.3
Reaction time omissions0.81.32.0-1.0-0.71.2-1.0-1.2-1.11.21.11.2-1.2-1.0-1.41.41.1
Reaction time false alarm rate1.92.64.7-2.1-2.22.0-1.9-1.8-1.71.21.81.5-1.6-1.3-1.11.10.1
Reaction time premature initiation rate0.40.61.3-0.6-0.50.8-0.6-0.8-0.90.81.10.7-0.8-1.2-0.70.7-0.0
Reaction time premature initiations0.10.20.4-0.10.00.1-0.3-0.2-0.40.30.50.4-0.4-0.6-0.60.6-0.3
Std. dev. reaction times0.10.32.8-0.4-0.30.4-0.3-0.2-0.00.4-0.20.2-0.1-0.0-0.20.21.7
Reaction time trials completed0.20.81.51.01.1-1.20.61.11.0-0.9-1.1-0.60.91.00.0-0.0-1.0
Reaction time trials AUC0.20.71.40.91.0-1.20.61.10.9-0.9-1.1-0.50.81.00.0-0.0-0.8
Run reversals in cocaine runway, females1.71.93.31.71.8-1.61.81.70.9-1.1-0.2-1.41.11.31.3-1.3-0.8
Run reversals in cocaine runway, males0.40.40.90.80.9-0.80.40.80.7-1.0-0.8-0.30.70.8-0.10.10.1
Latency to leave start box in cocaine runway0.81.12.80.60.4-0.61.00.80.8-0.9-0.5-1.21.01.41.7-1.7-1.2
Latency to leave start box in cocaine runway, F2.22.84.71.10.9-1.31.51.51.5-1.5-1.3-1.91.72.02.2-2.2-2.1
Latency to leave start box in cocaine runway, M0.20.20.7-0.5-0.50.5-0.1-0.5-0.50.40.60.1-0.4-0.30.4-0.40.9
Std. dev. time between licks in bursts0.20.31.00.91.0-0.60.80.70.3-0.4-0.0-0.50.30.30.3-0.3-0.3
Total sessions with >9 infusions0.40.45.50.10.20.00.3-0.0-0.20.20.5-0.1-0.2-0.10.1-0.1-2.3
Short access day 1 total inactive lever presses0.30.61.7-0.5-0.40.4-0.7-0.7-1.00.41.10.9-0.8-0.6-0.80.8-1.3
Short access day 10 total inactive lever presses0.00.10.30.20.50.1-0.00.0-0.4-0.10.50.4-0.10.5-0.40.40.1
Short access day 1 total infusions0.40.910.10.50.7-0.10.50.20.1-1.00.1-0.30.20.30.1-0.1-3.2
Short access day 10 total infusions2.84.68.0-2.0-1.91.8-1.8-2.2-2.52.72.82.1-2.5-2.4-1.91.9-0.1
Short access total infusions0.91.22.1-1.0-1.01.1-0.9-1.1-1.31.11.41.0-1.2-1.2-0.90.8-1.4
Short access day 1 locomotion0.71.25.9-0.40.30.3-0.3-0.7-1.30.21.80.9-1.1-0.8-1.21.2-2.4
Short access day 10 total locomotion1.66.411.0-2.5-2.33.3-2.4-3.0-3.02.63.12.6-2.8-2.2-2.02.00.4
Short access total locomotion1.32.04.9-1.0-0.71.4-0.9-1.4-1.81.32.21.4-1.6-1.2-1.31.3-1.7
One hour access (0.3 mA shock)1.21.42.8-1.5-1.61.7-1.3-1.6-1.10.81.01.1-1.2-1.3-0.90.9-0.1
Compulsive drug intake0.20.31.3-0.6-0.70.5-0.4-0.50.00.2-0.50.2-0.2-0.5-0.20.21.2
One hour access (shock baseline)0.30.71.3-0.7-0.60.7-0.7-0.7-0.91.01.10.8-0.8-0.9-0.80.8-0.6
Social response proportion0.30.40.8-0.6-0.80.5-0.6-0.7-0.5-0.30.50.5-0.7-0.9-0.60.60.3
Social responses1.72.33.7-1.8-1.91.4-1.4-1.6-1.71.41.81.3-1.7-1.8-1.11.10.5
Social time0.10.10.50.2-0.2-0.40.10.10.6-0.4-0.7-0.40.4-0.00.2-0.20.4
Soleus weight0.10.31.70.30.3-0.20.30.40.4-0.5-0.4-0.30.60.50.2-0.2-1.3
Bone: stiffness1.12.03.0-1.4-1.21.3-1.5-1.3-1.51.31.41.6-1.5-1.5-1.71.70.7
Tibialis anterior weight0.10.21.7-0.10.30.10.40.1-0.80.11.30.2-0.50.40.2-0.2-0.4
Time to tail flick, vehicle, before self-admin0.30.31.3-0.3-0.30.1-0.5-0.20.51.1-1.00.20.3-0.0-0.50.51.2
Time to tail flick, vehicle, after self-admin0.10.21.10.00.4-0.2-0.30.20.10.0-0.40.5-0.00.1-1.01.10.7
Time to tail flick, test, before self-admin0.91.12.3-1.3-1.31.3-1.1-1.2-0.91.30.60.9-0.9-0.4-0.50.51.5
Time to tail flick, test, after self-admin1.31.42.2-1.4-1.41.1-1.2-1.1-1.11.50.91.2-1.2-1.1-1.11.00.9
Delta time to tail flick, vehicle, before/after SA1.11.21.7-1.1-0.71.2-1.0-1.0-1.30.21.21.3-1.3-0.8-1.21.21.1
Delta time to tail flick, test, before/after SA0.10.10.30.20.0-0.4-0.30.30.3-0.4-0.40.10.2-0.3-0.50.5-0.1
Tibia length0.10.21.3-0.00.0-0.2-0.20.10.10.2-0.20.2-0.0-0.3-0.70.7-1.2
Ambulatory time before self-admin0.51.64.11.00.9-1.01.01.01.4-2.0-1.6-1.31.51.41.2-1.2-0.6
Ambulatory time after self-admin0.10.10.3-0.5-0.50.3-0.3-0.5-0.1-0.4-0.00.0-0.1-0.30.2-0.20.0
Bone: tissue strength1.31.31.91.21.2-1.21.01.31.3-1.3-1.4-1.21.30.80.9-0.9-1.0
Total heroin consumption0.10.10.5-0.5-0.70.3-0.4-0.50.20.3-0.4-0.20.2-0.00.3-0.3-0.1
Bone: trabecular number0.30.61.3-0.6-0.40.6-1.0-0.7-0.70.90.41.0-0.7-0.8-1.11.10.8
Bone: trabecular spacing0.20.20.70.3-0.1-0.40.50.40.4-0.4-0.2-0.70.40.30.8-0.8-0.2
Bone: trabecular thickness0.81.12.7-0.7-0.30.7-0.9-0.7-1.01.20.91.3-1.1-0.9-1.61.60.7
Bone: trabecular tissue density0.50.92.41.31.5-1.21.11.10.9-0.9-0.7-0.70.70.4-0.10.1-1.2
Water consumed over 24 hours0.10.21.2-0.2-0.10.30.1-0.4-0.60.30.80.1-0.4-0.30.3-0.3-1.1
Number of responses in last shaping day0.50.62.60.91.0-0.90.70.90.5-0.2-0.2-0.40.71.00.2-0.1-1.6