Hub : Genes

LOC108352129

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC108352129	0.04	0.03	2.7e-05	0.03	0.04	0.02	0.02	5.2e-04	3.9e-05	1.8e-03	7.0e-04
2	PL	gene expression	LOC108352129	0.06	0.04	1.8e-06	0.06	0.05	0.06	0.06	9.2e-07	1.4e-06	1.1e-06	8.2e-07
3	BLA	gene expression	LOC108352129	0.39	0.24	1.5e-03	0.04	0.04	0.07	0.04	2.7e-03	2.1e-03	1.0e-04	2.8e-03
4	Brain	gene expression	LOC108352129	0.05	0.04	4.9e-03	0	0.02	0.02	0.01	1.0e-01	4.7e-03	4.8e-03	7.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.3	4.3	-2.1	-1.7	1.3	-0.7
Area under the delay curve	0.1	0.2	0.4	-0.6	-0.3	-0.3	-0.2
BMI with tail	2.2	7.1	9.9	2.8	3.2	-1.0	3.1
BMI without tail	0.1	0.2	0.3	0.4	0.3	-0.3	0.5
Body weight	4.3	18.2	27.6	5.1	5.2	-1.7	4.0
Weight adjusted by age	0.7	0.8	1.1	0.5	0.9	-1.1	1.0
Bone surface	0.1	0.3	0.6	-0.1	0.3	0.6	0.8
Bone volume	0.3	0.5	0.9	-0.5	0.1	0.8	0.9
Breakpoint value in progressive ratio session	0.4	0.4	0.8	0.3	0.3	0.9	-0.9
Number of licking bursts	0.2	0.3	0.7	-0.5	0.3	-0.0	0.8
Context. condit. distance diff. score	0.9	1.1	2.6	1.2	0.6	-1.6	-0.1
Locomotion velocity, session 1	0.4	0.5	0.8	0.8	0.8	-0.0	0.9
Locomotion distance, session 1	2.2	2.9	4.6	1.9	2.1	0.1	1.8
Locomotion velocity, session 2	0.1	0.1	0.3	0.5	0.2	0.1	-0.2
Locomotion distance, session 2	0.7	0.9	1.7	0.6	1.0	1.3	0.9
Locomotion velocity, session 3	0.4	0.5	1.1	0.0	-0.4	0.7	-1.1
Locomotion distance, session 3	0.1	0.1	0.4	0.6	0.4	0.2	0.1
Stereotopy head waving bouts, day 3	2.1	2.5	4.0	-1.9	-2.0	0.7	-1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.5	-0.4	0.1	-0.1
Locomotion velocity, session 7	1.4	1.5	2.2	1.1	1.5	-0.8	1.3
Locomotion distance, session 7	0.4	0.5	0.7	0.7	0.8	-0.6	0.8
Stereotopy head waving bouts, day 7	0.2	0.2	0.7	-0.8	-0.5	-0.0	-0.0
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.6	-0.4	0.2	-0.2
Locomotion velocity, session 8	5.2	6.2	10.2	3.2	2.9	-1.8	1.7
Locomotion distance, session 8	1.0	1.5	2.3	1.5	1.5	-0.7	1.0
Degree of sensitization distance	1.0	1.0	1.3	1.0	1.0	-1.2	0.9
Degree of sensitization stereotypy	0.4	0.4	1.2	-1.1	-0.6	-0.1	0.1
Conditioned locomotion	0.2	0.3	0.5	-0.4	-0.7	-0.2	-0.7
Cocaine response after cond. corrected	0.6	0.7	1.3	-1.1	-0.2	0.0	1.1
Cocaine response after cond. not corrected	0.8	0.9	1.8	-1.4	-0.2	-0.3	1.2
Cocaine response before conditioning	0.2	0.2	0.3	-0.5	-0.4	-0.5	-0.2
Saline control response	0.7	0.9	2.2	0.2	0.9	-0.7	1.5
Bone: connectivity density	2.2	3.4	5.6	-2.4	-2.2	1.3	-1.3
Bone: cortical apparent density	6.3	8.3	11.8	-3.1	-3.4	2.0	-2.8
Bone: cortical area	0.0	0.0	0.1	-0.4	-0.0	-0.0	0.1
Bone: cortical porosity	0.2	0.3	0.7	-0.4	0.2	0.2	0.9
Bone: cortical porosity	0.4	0.5	1.6	-0.4	0.4	-0.0	1.3
Bone: cortical thickness	0.8	1.3	2.1	-1.5	-1.3	0.3	-1.1
Bone: cortical thickness	4.7	5.4	7.2	-2.6	-2.7	1.6	-2.3
Bone: cortical tissue density	6.3	8.3	11.9	-3.1	-3.4	2.0	-2.8
Condit. Reinf. active minus inactive responses	1.4	1.6	2.6	-1.0	-1.4	0.9	-1.6
Condit. Reinf. active-inactive response ratio	1.9	2.1	4.1	-1.1	-1.7	0.2	-2.0
Condit. Reinf. active responses	1.1	1.3	1.8	-1.1	-1.3	0.8	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.5	0.1	0.2	0.5
Incentive salience index mean	2.2	2.7	3.2	-1.6	-1.8	1.6	-1.6
Condit. Reinf. lever presses	1.0	1.3	2.3	-1.3	-1.0	1.5	-0.5
Condit. Reinf. active minus inactive responses	0.9	1.1	1.5	-1.1	-0.9	1.2	-0.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.0	-0.9	-0.6	1.4	-0.3
Condit. Reinf. active responses	1.3	1.9	3.3	-1.5	-1.2	1.8	-0.7
Condit. Reinf. inactive responses	1.3	1.6	2.6	-1.6	-1.2	1.4	-0.4
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.3	-0.4	0.4	-0.6
Condit. Reinf. lever reinforcers received	1.6	2.2	3.7	-1.6	-1.3	1.9	-1.0
Conditioned reinforcement - actives	0.5	0.5	0.9	-1.0	-0.7	0.4	-0.6
Conditioned reinforcement - inactives	2.7	3.0	3.5	-1.5	-1.9	1.9	-1.7
Conditioned locomotion	0.3	0.3	0.8	-0.9	-0.5	-0.5	-0.0
Patch foraging indifference point 0 sec	2.2	3.5	5.2	-1.8	-2.3	1.4	-2.0
Patch foraging indifference point AUC	0.1	0.1	0.2	0.2	0.2	-0.4	0.4
Delay disc. indifference point, 0s delay	0.6	0.7	1.4	-1.2	-0.8	0.4	-0.6
Delay disc. indifference point, 16s delay	0.7	0.7	1.2	-0.7	-1.1	0.2	-1.0
Delay disc. indifference point, 2s delay	0.4	0.5	1.7	-1.3	-0.3	0.3	0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.0	-0.3	-0.8	-0.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	-1.0	-0.3	0.0	-0.4
Delay disc. indifference point, 8s delay	0.3	0.3	1.0	-0.4	-0.2	-1.0	0.0
Indifference point function ln k	0.1	0.2	0.5	0.0	-0.4	-0.2	-0.7
Indifference point function log k	0.1	0.2	0.5	0.0	-0.4	-0.2	-0.7
Patch foraging total patch changes 0 sec	1.6	2.6	4.1	-1.5	-2.0	1.1	-1.7
Patch foraging total patch changes 12 sec	3.7	4.8	7.8	-2.8	-2.4	1.9	-1.4
Patch foraging total patch changes 18 sec	0.5	0.6	1.0	-0.9	-1.0	0.5	-0.6
Patch foraging total patch changes 24 sec	0.9	1.1	2.3	-1.5	-1.2	-0.6	-0.6
Patch foraging total patch changes 6 sec	2.4	3.5	4.6	-1.9	-2.1	2.0	-1.4
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.3	-0.3	0.6	-0.1
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.2	-0.4	0.8	-0.6
Patch foraging water rate 12 sec	0.1	0.2	0.2	0.3	0.3	-0.5	-0.5
Patch foraging water rate 18 sec	0.2	0.3	0.7	-0.8	-0.4	0.5	-0.1
Patch foraging water rate 24 sec	1.1	1.5	3.9	-0.9	-0.9	2.0	-0.8
Patch foraging water rate 6 sec	1.4	2.0	2.3	-1.5	-1.4	1.5	-1.3
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	3.3	-0.5	-0.9	1.6	-1.8
Distance traveled before self-admin	0.3	0.3	1.0	0.2	-0.1	1.0	0.3
Distance traveled after self-admin	0.8	0.9	1.9	1.4	0.8	-0.5	0.8
Extensor digitorum longus weight	7.1	27.9	40.3	6.4	5.8	-5.0	3.6
Bone: elastic displacement	0.0	0.0	0.1	-0.0	-0.0	0.3	-0.1
Bone: elastic work	0.2	0.2	0.8	-0.2	0.1	0.9	0.0
Bone: endosteal estimation	2.2	4.8	6.9	2.3	2.4	-1.1	2.6
Bone: endosteal perimeter	1.1	2.2	3.3	1.8	1.7	-0.8	1.4
Epididymis fat weight	0.2	0.4	0.8	0.6	0.6	0.9	0.2
Delta time in closed arm before/after self-admin	3.3	3.2	5.4	2.1	2.3	-1.0	1.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	-0.2	0.6	0.0
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	0.3	0.6	-0.6	-0.4
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.1	0.3	0.1
Extinction: sum of active levers before priming	2.6	2.5	3.5	1.3	1.5	-1.9	1.6
Active lever presses in extinction session 6	0.7	0.7	1.1	-1.0	-0.5	1.1	0.5
Bone: final force	0.3	0.5	1.1	-1.0	-0.2	0.2	1.0
Bone: final moment	0.3	0.5	1.3	-0.8	0.0	0.1	1.2
Food consumed during 24 hour testing period	0.8	0.9	1.4	1.0	1.2	-0.8	0.8
Glucose	0.2	0.2	0.6	-0.5	-0.0	0.3	0.7
Heart weight	2.0	2.8	5.3	2.3	1.9	0.3	1.4
Delay discount hyperbolic model param	0.1	0.1	0.3	0.6	0.2	0.2	0.1
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.6	-0.2	0.5	-1.0
Intermittent access intake escalation	0.5	0.4	1.0	-0.6	-0.2	0.6	-1.0
Intermittent access intake escalation 2	0.1	0.1	0.2	0.0	0.5	-0.1	-0.2
Intermitt. access day 1 inactive lever presses	2.8	3.0	6.3	-1.3	-1.4	2.5	-1.5
Intermitt. access day 15 inactive lever presses	4.5	4.9	5.3	-2.3	-2.2	2.3	-2.0
Intermitt. access escalation Index	4.3	3.8	9.0	1.4	1.5	-3.0	1.4
Intermittent access day 1 total infusions	0.4	0.4	1.1	-0.5	-0.7	1.0	-0.2
Intermittent access day 15 total infusions	0.8	0.9	1.4	-0.8	-0.7	1.2	-1.0
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.3	-0.9	-0.8	1.2	-0.9
Intermittent access total infusions	0.6	0.7	1.9	-0.4	-0.5	1.4	-0.7
Intermittent access day 1 locomotion	0.6	0.6	1.2	-0.6	-0.9	1.1	-0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.7	-0.6	0.5	-0.2
Intermittent access total locomotion	0.9	1.0	1.1	-1.0	-1.1	1.0	-0.9
Intermittent access standard deviation	2.6	2.8	4.8	-1.3	-1.3	1.7	-2.2
Left kidney weight	0.5	1.3	4.3	2.1	1.0	-0.3	0.0
Right kidney weight	0.1	0.3	0.7	0.8	0.6	0.0	0.6
Cocaine induced anxiety	2.8	3.2	3.8	1.7	2.0	-1.7	1.9
Post-drug Anxiety	0.4	0.5	0.9	0.4	0.6	-0.7	1.0
Baseline Anxiety	1.6	1.7	2.4	-1.5	-1.5	0.8	-1.1
Tail length	0.1	0.4	1.0	1.0	0.5	-0.2	-0.6
Length with tail	1.7	6.1	13.0	3.6	3.1	-1.0	1.1
Length without tail	2.9	6.3	10.4	3.2	3.2	-0.6	2.1
Times rat made contact with spout	0.8	1.0	2.1	-1.1	-0.7	1.5	-0.0
Lifetime Intake	0.9	1.0	2.6	-0.5	-0.6	1.6	-0.9
Liver weight, left	0.1	0.1	0.2	-0.0	0.0	0.4	-0.4
Liver weight, right	0.5	0.9	1.3	-0.7	-1.0	1.1	-0.9
Locomotor activity	0.2	0.4	0.9	-0.9	-0.2	0.7	0.4
Locomotor testing distance	1.2	2.0	4.1	-2.0	-1.6	0.9	-0.8
Locomotor testing rearing	6.1	9.4	14.9	-3.2	-3.9	2.0	-2.8
Locomotion in novel chamber	4.5	5.6	8.8	-3.0	-2.5	2.5	-1.2
Locomotion in novel chamber post-restriction	0.4	0.4	1.2	-1.1	-0.4	0.5	0.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	0.5	0.4	0.1	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	-0.0	0.3	-0.8	0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	-0.6	-0.6	-0.4	-0.6
Bouts of movement, locomotor time 1	0.4	0.4	0.9	0.9	0.5	-0.7	0.5
Total resting periods, locomotor time 1	0.9	1.0	1.6	1.3	0.9	-0.8	1.1
Rest time, locomotor task time 1	0.1	0.1	0.2	0.0	-0.4	0.4	0.4
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.4	0.2	0.1	-0.1
Vertical activity count, locomotor time 1	0.4	0.4	1.5	0.2	1.2	-0.2	0.4
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.8	-1.3	-0.7	-0.5	-0.2
Bouts of movement, locomotor time 2	0.6	0.7	1.4	-0.3	-1.2	0.2	-1.1
Total resting periods, locomotor time 2	0.6	0.7	1.4	-0.1	-1.1	0.2	-1.2
Rest time, locomotor task time 2	0.5	0.6	1.2	1.1	0.8	-0.3	0.6
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.1	0.6	-0.2	0.8
Vertical activity count, locomotor time 2	0.5	0.5	1.2	0.4	1.1	-0.4	0.6
Light reinforcement 1	2.7	4.9	5.5	-2.3	-2.3	2.3	-1.8
Light reinforcement 2	0.8	1.1	3.1	-0.9	-0.4	1.8	0.4
Bone: marrow area	2.1	4.5	6.5	2.2	2.3	-1.0	2.6
Bone: maximum diameter	0.0	0.0	0.1	-0.2	0.0	0.1	0.2
Bone: maximum force	0.3	0.5	1.6	0.1	0.6	-0.2	1.2
Bone: maximum moment	0.4	0.6	1.8	0.2	0.8	-0.3	1.4
Mean time between licks in bursts	1.0	1.4	1.9	1.4	1.3	-0.9	1.0
Mean num. licks in bursts	0.5	0.6	1.2	-0.3	-0.7	1.1	-0.8
Cd content in liver	0.1	0.1	0.1	-0.3	-0.4	0.3	-0.3
Co content in liver	0.2	0.3	0.9	0.9	0.4	0.0	-0.2
Cu content in liver	0.4	0.5	1.4	0.2	-0.5	0.5	-1.2
Fe content in liver	0.9	1.1	1.8	1.2	1.3	-0.3	1.0
K content in liver	1.1	1.1	1.5	-1.1	-1.2	0.7	-1.0
Mg content in liver	1.9	2.0	4.1	-1.1	-1.6	0.0	-2.0
Mn content in liver	2.8	3.1	4.7	-1.6	-2.1	1.0	-2.2
Na content in liver	0.2	0.2	0.6	-0.5	0.0	0.2	0.8
Rb content in liver	1.4	1.7	2.6	-1.4	-1.6	0.9	-1.1
Se content in liver	5.9	7.2	8.9	-2.6	-3.0	2.5	-2.6
Sr content in liver	0.6	0.6	1.6	-0.1	-0.7	0.3	-1.3
Zn content in liver	3.3	3.6	4.1	-1.9	-2.0	2.0	-1.6
Bone: minimum diameter	0.5	1.0	1.4	1.0	1.2	-0.4	1.1
Time in familiar zone, hab. session 1	1.2	1.2	2.8	-0.5	0.2	1.7	1.2
Time in novel zone, hab. session 1	1.3	1.3	2.8	-0.8	-1.3	-0.1	-1.7
Total zone transitions, hab. session 1	1.0	1.4	2.8	1.7	1.3	-0.7	0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.1	0.0	0.4	-0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.7	0.5	-0.5	-0.2
Time in familiar zone, hab. session 2	0.6	0.6	1.7	-0.8	-0.3	1.3	0.1
Time in novel zone, hab. session 2	0.4	0.4	0.9	-0.4	-0.8	-0.1	-0.9
Total zone transitions, hab. session 2	0.8	1.1	1.6	1.1	1.3	-0.4	1.1
Total locomotion distance, hab. session 2	0.4	0.5	1.0	0.5	1.0	0.4	0.9
Locomotion velocity, hab. session 2	0.6	0.8	1.5	0.8	1.2	0.0	1.0
Novel to familiar place preference ratio	1.1	1.1	3.0	1.1	0.6	-1.7	-0.2
Novelty place preference	1.2	1.2	3.7	1.0	0.4	-1.9	-0.4
Time in novel zone, NPP test	0.8	0.8	2.9	0.5	0.0	-1.7	-0.5
Total zone transitions, NPP test	0.9	1.3	2.9	0.8	1.3	-0.2	1.7
Total locomotion distance, NPP test	0.3	0.4	1.1	0.0	0.5	0.4	1.0
Locomotion velocity, NPP test	0.5	0.7	1.4	0.7	1.0	0.0	1.2
Intraocular pressure	1.9	2.7	3.6	1.9	1.7	-1.4	1.5
Delta distance traveled before/after self-admin	1.4	1.5	2.9	1.3	1.0	-1.7	0.6
Delta ambulatory time before/after self-admin	2.0	2.1	5.0	1.2	1.0	-2.2	1.1
Parametrial fat weight	1.1	2.2	3.1	-1.6	-1.4	1.8	-1.1
Pavlov. Cond. lever latency	2.1	2.6	5.1	2.0	1.2	-2.3	0.0
Pavlov. Cond. magazine entry latency	7.0	9.0	14.5	-3.8	-3.2	2.9	-1.5
Pavlov. Cond. change in total contacts	8.7	9.3	11.6	-3.3	-3.4	2.9	-2.5
Pavlov. Cond. index score	5.7	7.2	11.7	-3.4	-2.7	3.0	-0.9
Pavlov. Cond. latency score	4.1	5.3	8.8	-3.0	-2.2	2.7	-0.5
Pavlov. Cond. lever contacts	1.7	2.1	4.2	-1.7	-1.0	2.1	0.2
Pavlov. Cond. magazine entry number	9.3	11.6	17.7	4.2	3.7	-3.4	1.9
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.9	1.4	0.9	-1.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	6.5	8.0	12.9	-3.6	-2.9	3.0	-1.2
Pavlov. Cond. response bias	7.1	8.6	12.8	-3.6	-3.2	3.0	-1.7
Pavlov. Cond. lever latency	0.4	0.5	1.1	0.7	0.4	-1.1	0.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.2	0.8	-0.1	0.5
Pavlov. Cond. change in total contacts	0.8	1.1	1.1	-1.1	-1.1	1.0	-1.0
Pavlov. Cond. index score	0.2	0.2	0.6	-0.5	0.0	0.8	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.1	0.5	0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.7	-1.1	-0.5	1.3	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.2	-0.3	-0.5	-0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.4	2.9	1.4	0.5	-1.7	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.4	0.2	0.8	0.2
Pavlov. Cond. response bias	0.9	1.2	2.6	-1.3	-0.7	1.6	-0.3
Time in closed arm before self-admin	1.9	2.2	4.4	-1.1	-2.1	0.9	-1.5
Time in closed arm after self-admin	0.3	0.3	0.6	0.8	0.0	-0.4	-0.7
Time in open arm before self-admin	1.9	2.1	3.9	1.6	2.0	-1.1	0.9
Time in open arm after self-admin	0.4	0.4	0.9	0.7	0.9	0.2	0.5
Bone: periosteal estimation	0.4	0.9	2.0	0.7	1.0	-0.3	1.4
Bone: periosteal perimeter	0.9	1.5	2.4	1.1	1.5	-0.4	1.5
Bone: post-yield work	1.3	1.8	2.3	1.5	1.5	-1.0	1.2
Progressive ratio test 1 active lever presses	0.8	0.8	1.6	-0.9	-1.3	0.9	-0.4
Progressive ratio test 1 breakpoint	0.7	0.7	1.4	-0.8	-1.2	0.8	-0.3
Progressive ratio test 1 inactive lever presses	2.5	2.7	4.1	-1.3	-1.7	2.0	-1.5
Progressive ratio test 2 active lever presses	1.6	1.7	2.0	-1.3	-1.4	1.4	-1.1
Progressive ratio test 2 breakpoint	1.1	1.3	1.6	-1.2	-1.3	1.1	-0.9
Progressive ratio test 2 inactive lever presses	1.1	1.2	2.3	-0.8	-1.0	1.5	-1.0
Incentive Sensitization - Responses	1.5	1.5	2.0	-1.4	-1.2	1.4	-0.9
Incentive Sensitization - Breakpoint	1.3	1.4	1.8	-1.3	-1.2	1.3	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	-0.5	0.4	0.1
Progressive ratio	0.4	0.5	1.9	-0.3	0.2	1.4	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.5	-0.4	0.0	0.1
Seeking ratio, punishment vs. effort	0.6	0.8	2.9	-0.1	-0.3	-1.7	0.1
Retroperitoneal fat weight	0.2	0.5	1.7	0.4	0.1	1.3	0.3
Reaction time number correct	0.8	1.2	2.6	1.0	1.6	-0.5	1.0
Reaction time mean minus median	0.4	0.6	1.1	0.6	0.8	-1.0	0.4
Reaction time mean minus median AUC	0.2	0.3	0.8	-0.0	0.4	-0.9	0.4
Reaction time num false alarms	0.3	0.5	0.8	-0.9	-0.0	0.9	0.5
Reaction time num false alarms AUC	0.2	0.3	0.6	-0.8	0.2	0.7	0.6
Reaction time trials correct on left	0.8	1.2	2.6	1.0	1.6	-0.5	1.0
Reaction time trials on left	0.8	1.2	2.5	1.0	1.6	-0.5	1.0
Reaction time mean	0.5	0.6	1.8	-0.4	-0.8	-0.2	-1.3
Reaction time mean AUC	0.5	0.7	1.9	-0.4	-0.8	-0.0	-1.4
Median of all reaction times	1.3	1.8	3.4	-1.1	-1.5	0.5	-1.8
Reaction time omissions	0.6	0.9	1.6	-1.3	-1.0	0.7	-0.7
Reaction time false alarm rate	0.4	0.6	1.3	-1.1	-0.6	0.9	-0.0
Reaction time premature initiation rate	0.2	0.2	0.4	-0.6	-0.2	0.3	-0.5
Reaction time premature initiations	0.1	0.2	0.7	0.2	0.8	-0.2	0.1
Std. dev. reaction times	0.1	0.1	0.3	0.0	0.2	-0.6	-0.1
Reaction time trials completed	0.8	1.2	2.5	1.0	1.6	-0.5	1.0
Reaction time trials AUC	0.7	1.0	2.2	0.9	1.5	-0.6	0.9
Run reversals in cocaine runway, females	1.6	1.6	2.6	1.6	1.3	-1.5	-0.1
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.8	-0.6	0.1	-0.2
Latency to leave start box in cocaine runway	1.0	1.0	2.0	1.4	1.2	0.8	0.4
Latency to leave start box in cocaine runway, F	1.0	1.1	1.9	1.4	1.4	0.2	0.8
Latency to leave start box in cocaine runway, M	1.8	1.7	4.4	-0.2	-0.9	2.1	-1.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.3	0.4	-0.2	0.4
Total sessions with >9 infusions	0.9	1.0	1.1	-0.9	-1.1	1.0	-1.0
Short access day 1 total inactive lever presses	3.1	3.5	6.3	-1.6	-1.6	2.5	-1.5
Short access day 10 total inactive lever presses	0.2	0.2	0.4	0.4	0.7	0.0	-0.3
Short access day 1 total infusions	2.3	2.5	5.6	-0.8	-1.3	2.4	-1.4
Short access day 10 total infusions	0.6	0.7	1.7	-0.7	-0.7	1.3	-0.3
Short access total infusions	1.3	1.4	3.3	-0.5	-0.8	1.8	-1.2
Short access day 1 locomotion	4.1	4.4	5.7	-2.1	-2.1	2.4	-1.8
Short access day 10 total locomotion	1.0	1.1	2.0	-1.4	-1.4	0.4	-0.5
Short access total locomotion	1.0	1.0	1.4	-0.7	-1.0	1.2	-1.1
One hour access (0.3 mA shock)	0.1	0.1	0.4	-0.1	-0.1	0.6	-0.4
Compulsive drug intake	0.3	0.4	0.7	0.5	0.4	-0.8	-0.5
One hour access (shock baseline)	0.6	0.7	2.1	-0.6	-0.5	1.4	-0.2
Social response proportion	0.3	0.3	0.7	0.5	0.4	0.3	0.9
Social responses	0.6	0.8	2.7	-0.2	0.0	1.6	0.7
Social time	0.5	0.7	2.2	0.2	0.7	-0.1	1.5
Soleus weight	0.6	1.9	5.5	-0.2	0.9	-1.1	2.3
Bone: stiffness	0.2	0.3	0.7	-0.0	0.3	-0.6	0.8
Tibialis anterior weight	1.4	5.0	6.4	2.4	2.5	-1.7	2.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.2	0.2	0.1	0.5
Time to tail flick, test, before self-admin	2.5	2.4	4.6	1.3	1.6	-2.1	0.9
Time to tail flick, test, after self-admin	1.0	1.0	3.3	-0.4	-0.4	1.8	0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	-0.4	0.2	-0.1	0.8
Delta time to tail flick, test, before/after SA	4.4	4.0	9.1	-1.7	-1.9	3.0	-0.5
Tibia length	2.1	6.0	9.5	2.1	2.9	-1.2	3.1
Ambulatory time before self-admin	0.1	0.1	0.4	0.3	-0.1	0.6	-0.1
Ambulatory time after self-admin	1.7	1.9	3.3	1.8	1.2	-1.0	1.3
Bone: tissue strength	0.8	0.8	1.2	1.0	1.1	-0.6	0.8
Total heroin consumption	1.0	1.2	2.0	-1.4	-1.0	1.3	-0.3
Bone: trabecular number	3.1	4.9	9.1	-3.0	-2.4	1.9	-0.9
Bone: trabecular spacing	2.1	2.8	4.2	1.4	1.9	-1.2	2.1
Bone: trabecular thickness	0.2	0.2	0.7	-0.4	-0.3	0.8	-0.2
Bone: trabecular tissue density	0.5	0.8	1.8	-0.0	-0.9	-0.7	-1.3
Water consumed over 24 hours	0.1	0.2	0.3	0.2	0.6	0.1	0.5
Number of responses in last shaping day	1.8	1.9	3.7	-0.6	-1.0	1.9	-1.6