Hub : Genes

LOC108351921

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC108351921	0.04	0.02	3.4e-03	0.02	0.02	0.01	0.02	3.6e-03	6.6e-03	4.1e-02	1.9e-03
2	Brain	gene expression	LOC108351921	0.06	0.04	7.9e-04	0.01	0.03	0.04	0.03	1.4e-02	3.6e-04	5.0e-05	6.0e-04
3	NAcc	gene expression	LOC108351921	0.08	0.05	3.3e-06	0.04	0.04	0.04	0.04	8.1e-06	2.5e-05	4.1e-05	1.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.8	3.1	4.4	-2.1	0.8	2.1
Area under the delay curve	0.2	0.3	0.3	-0.6	0.3	-0.6
BMI with tail	1.5	4.9	6.1	2.2	-2.0	-2.5
BMI without tail	0.1	0.2	0.6	-0.2	0.7	0.0
Body weight	0.4	1.6	3.2	0.9	-1.8	-0.9
Weight adjusted by age	4.2	4.8	5.6	2.4	-2.1	-2.1
Bone surface	0.3	0.6	1.0	-0.8	-0.4	1.0
Bone volume	1.0	1.7	2.9	-1.5	0.2	1.7
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.3	0.6	0.3
Number of licking bursts	0.6	0.7	0.9	-0.9	0.9	0.7
Context. condit. distance diff. score	0.4	0.4	0.7	-0.8	0.8	0.2
Locomotion velocity, session 1	0.1	0.1	0.3	-0.1	-0.0	-0.6
Locomotion distance, session 1	2.4	3.1	4.5	1.8	-1.2	-2.1
Locomotion velocity, session 2	3.5	4.1	4.9	2.2	-1.8	-2.0
Locomotion distance, session 2	1.9	2.7	3.2	1.8	-1.4	-1.7
Locomotion velocity, session 3	0.2	0.2	0.3	0.3	-0.5	-0.5
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	0.2	0.4
Stereotopy head waving bouts, day 3	0.2	0.3	0.4	-0.6	0.5	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.5	0.4	-0.0
Locomotion velocity, session 7	3.4	3.7	4.2	1.9	-1.8	-2.0
Locomotion distance, session 7	1.2	1.5	1.9	1.0	-1.3	-1.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.0	0.2	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.9	0.5	-0.2	-0.9
Locomotion velocity, session 8	1.7	2.0	2.2	1.3	-1.5	-1.5
Locomotion distance, session 8	1.4	2.0	2.5	1.4	-1.2	-1.6
Degree of sensitization distance	1.4	1.4	2.5	0.8	-1.1	-1.6
Degree of sensitization stereotypy	0.2	0.2	0.5	0.3	-0.1	-0.7
Conditioned locomotion	0.7	0.9	1.5	-1.2	0.5	1.0
Cocaine response after cond. corrected	0.3	0.4	1.0	-0.4	1.0	-0.1
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.1	0.7	-0.5
Cocaine response before conditioning	1.4	1.7	2.0	1.4	-1.1	-1.4
Saline control response	0.8	1.0	1.2	0.9	-1.1	-1.0
Bone: connectivity density	0.7	1.1	1.7	-1.2	0.4	1.3
Bone: cortical apparent density	5.5	7.3	9.9	3.1	-2.7	-2.2
Bone: cortical area	0.5	0.8	2.2	0.2	-1.5	-0.4
Bone: cortical porosity	0.8	0.9	1.7	-0.9	0.2	1.3
Bone: cortical porosity	0.5	0.6	1.1	-0.8	-0.1	1.0
Bone: cortical thickness	0.6	0.9	2.3	0.4	-1.5	-0.5
Bone: cortical thickness	0.2	0.2	0.5	0.2	-0.7	-0.5
Bone: cortical tissue density	5.4	7.1	9.9	3.1	-2.6	-2.1
Condit. Reinf. active minus inactive responses	0.8	0.9	1.6	-0.6	0.9	-1.2
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.5	-0.9	0.9	-1.2
Condit. Reinf. active responses	0.6	0.7	1.9	-0.1	0.5	-1.4
Condit. Reinf. inactive responses	0.8	0.9	1.3	1.1	-0.5	-1.1
Incentive salience index mean	0.4	0.5	0.8	-0.4	0.6	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	-0.2	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.5	-1.2	1.0	-0.1
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.9	-1.7	1.4	0.7
Condit. Reinf. active responses	0.2	0.3	0.4	-0.5	0.6	-0.6
Condit. Reinf. inactive responses	0.9	1.2	1.5	1.2	-0.8	-1.1
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.5	0.6	-0.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	-0.4	0.8	-0.7
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.7	0.1	-0.4
Conditioned reinforcement - inactives	0.2	0.3	0.5	0.1	-0.6	-0.7
Conditioned locomotion	0.4	0.4	0.9	0.5	-0.5	-0.9
Patch foraging indifference point 0 sec	0.6	1.0	1.7	1.1	-1.3	-0.4
Patch foraging indifference point AUC	0.2	0.3	0.6	0.1	-0.8	-0.4
Delay disc. indifference point, 0s delay	2.2	2.5	2.5	1.6	-1.6	-1.6
Delay disc. indifference point, 16s delay	1.3	1.3	2.1	-1.3	1.4	0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.1	-0.5	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.3	-0.3
Delay disc. indifference point, 4s delay	1.0	1.0	1.4	0.6	-1.2	-1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.4	-0.3
Indifference point function ln k	0.1	0.1	0.3	0.6	0.0	-0.3
Indifference point function log k	0.1	0.1	0.3	0.6	0.0	-0.3
Patch foraging total patch changes 0 sec	0.4	0.7	1.0	0.9	-1.0	-0.4
Patch foraging total patch changes 12 sec	0.6	0.7	1.4	0.9	-1.2	-0.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.0	-0.2	0.0
Patch foraging total patch changes 24 sec	1.1	1.3	3.1	0.9	-1.8	-0.3
Patch foraging total patch changes 6 sec	0.3	0.4	1.2	0.2	-1.1	0.1
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.0	0.4	0.7
Patch foraging water rate 0 sec	0.1	0.2	0.3	-0.3	0.5	-0.6
Patch foraging water rate 12 sec	0.3	0.4	0.6	-0.5	0.8	0.6
Patch foraging water rate 18 sec	0.2	0.2	0.6	0.3	0.8	-0.1
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.3	0.6	-0.2
Patch foraging water rate 6 sec	0.2	0.2	0.3	-0.4	0.5	0.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.6	-0.8	0.5	0.4
Distance traveled before self-admin	0.3	0.3	0.8	-0.3	0.3	0.9
Distance traveled after self-admin	0.4	0.4	1.2	-0.1	0.3	1.1
Extensor digitorum longus weight	5.4	21.4	27.2	5.2	-4.3	-4.3
Bone: elastic displacement	1.3	1.5	2.1	-1.3	0.9	1.4
Bone: elastic work	0.6	0.8	1.3	-1.1	0.1	1.0
Bone: endosteal estimation	0.1	0.2	0.4	-0.6	0.3	0.4
Bone: endosteal perimeter	0.1	0.1	0.3	-0.5	-0.2	0.2
Epididymis fat weight	0.1	0.1	0.2	0.4	-0.5	-0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.6	0.1	-0.2
Delta time in open arm before/after self-admin	1.8	1.7	2.9	-1.7	0.7	1.3
Diff in mean of infusions in LGA sessions	1.3	1.4	1.8	-1.0	1.3	1.2
Delay discount exponential model param	0.3	0.3	0.5	0.7	-0.4	0.4
Extinction: sum of active levers before priming	2.7	2.7	3.5	-1.8	1.1	1.9
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.5	-0.3	0.0
Bone: final force	0.7	1.2	2.2	0.8	-1.5	-0.9
Bone: final moment	0.6	1.0	1.7	0.8	-1.3	-0.9
Food consumed during 24 hour testing period	0.6	0.7	1.1	0.6	-0.8	-1.1
Glucose	0.9	1.4	1.4	-1.1	1.2	1.2
Heart weight	0.8	1.1	1.4	1.0	-1.2	-0.9
Delay discount hyperbolic model param	0.2	0.2	0.4	0.4	-0.0	0.6
Intermittent access intake day 1-15 change	0.1	0.0	0.1	0.1	-0.2	-0.3
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.2	-0.3
Intermittent access intake escalation 2	0.5	0.5	0.8	-0.9	0.8	0.3
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.8	-0.1	0.8	0.9
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.3	0.0	-0.0
Intermitt. access escalation Index	0.3	0.3	0.6	0.2	-0.5	-0.8
Intermittent access day 1 total infusions	0.3	0.3	0.5	-0.6	0.7	-0.3
Intermittent access day 15 total infusions	0.4	0.5	0.7	-0.8	0.8	-0.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	-0.3	0.7	-0.6
Intermittent access total infusions	0.3	0.3	0.5	-0.7	0.7	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.2	-0.3	-0.4
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.0	-0.4	-0.5
Intermittent access total locomotion	0.2	0.2	0.5	0.3	-0.4	-0.7
Intermittent access standard deviation	2.4	2.6	3.1	-1.8	1.6	1.5
Left kidney weight	0.8	2.4	4.5	1.5	-2.1	-0.6
Right kidney weight	2.2	6.1	11.5	2.3	-3.4	-1.1
Cocaine induced anxiety	4.1	4.7	6.2	2.5	-2.0	-1.9
Post-drug Anxiety	1.8	2.0	3.5	1.3	-0.8	-1.9
Baseline Anxiety	1.9	2.1	3.6	-1.9	1.4	0.7
Tail length	0.6	1.8	2.5	-1.6	1.1	1.3
Length with tail	0.1	0.3	0.7	-0.3	-0.8	0.5
Length without tail	2.5	5.5	10.2	2.0	-3.2	-1.5
Times rat made contact with spout	2.5	2.9	3.7	-1.9	1.6	1.6
Lifetime Intake	0.3	0.3	0.5	-0.4	0.7	-0.5
Liver weight, left	0.2	0.3	0.7	-0.1	-0.3	0.8
Liver weight, right	0.4	0.7	1.2	-0.6	-1.1	0.7
Locomotor activity	0.6	1.0	2.0	-0.7	1.4	0.7
Locomotor testing distance	1.4	2.4	3.4	-1.3	1.8	1.4
Locomotor testing rearing	1.0	1.5	2.4	-1.0	1.5	1.1
Locomotion in novel chamber	3.6	4.4	5.4	2.3	-1.6	-2.3
Locomotion in novel chamber post-restriction	0.5	0.6	0.9	0.9	-0.4	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.5	-0.1	0.7	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.0	-0.5	0.4
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.1	1.3	-1.8	-1.1
Bouts of movement, locomotor time 1	0.7	0.7	1.5	-0.3	0.8	-1.2
Total resting periods, locomotor time 1	0.8	0.9	2.0	-0.0	0.8	-1.4
Rest time, locomotor task time 1	2.2	2.4	4.6	-1.6	2.2	0.3
Distance moved, locomotor task time 1	1.7	1.9	2.6	1.4	-1.6	-1.0
Vertical activity count, locomotor time 1	0.5	0.5	1.0	0.7	-1.0	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.4	0.2	0.2
Bouts of movement, locomotor time 2	0.7	0.8	2.0	0.4	0.2	-1.4
Total resting periods, locomotor time 2	0.6	0.7	1.8	0.5	0.1	-1.3
Rest time, locomotor task time 2	1.0	1.2	1.4	-1.1	1.2	0.9
Distance moved, locomotor task time 2	0.8	0.9	1.3	0.8	-1.0	-1.2
Vertical activity count, locomotor time 2	0.9	1.0	1.8	0.6	-0.9	-1.3
Light reinforcement 1	3.4	6.1	8.0	2.8	-2.6	-1.9
Light reinforcement 2	1.9	2.5	4.3	1.6	-2.1	-0.8
Bone: marrow area	0.1	0.2	0.3	-0.5	0.3	0.3
Bone: maximum diameter	0.1	0.3	0.5	-0.5	-0.2	0.7
Bone: maximum force	0.6	1.0	2.2	0.5	-1.5	-0.7
Bone: maximum moment	0.5	0.9	1.8	0.5	-1.3	-0.8
Mean time between licks in bursts	1.9	2.6	4.0	2.0	-1.8	-0.6
Mean num. licks in bursts	0.0	0.1	0.1	0.2	-0.3	-0.2
Cd content in liver	0.0	0.1	0.1	0.2	0.2	-0.2
Co content in liver	0.2	0.3	0.5	-0.5	0.7	-0.3
Cu content in liver	0.3	0.4	0.7	-0.9	0.5	-0.3
Fe content in liver	1.8	2.1	2.8	-1.5	1.1	1.7
K content in liver	1.5	1.5	3.6	0.9	-1.9	-0.1
Mg content in liver	0.6	0.6	1.6	0.5	-1.3	0.2
Mn content in liver	0.4	0.4	0.8	0.9	-0.6	-0.3
Na content in liver	0.6	0.6	1.5	-0.4	-0.5	1.2
Rb content in liver	1.1	1.4	3.0	1.1	-0.4	-1.7
Se content in liver	0.2	0.2	0.3	0.5	-0.6	-0.4
Sr content in liver	0.3	0.3	0.6	-0.4	0.4	0.8
Zn content in liver	0.4	0.4	0.6	0.4	-0.8	-0.8
Bone: minimum diameter	0.5	1.0	1.9	0.6	-1.4	-0.8
Time in familiar zone, hab. session 1	2.5	2.4	3.3	-1.6	1.8	1.2
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.1	0.4
Total zone transitions, hab. session 1	1.6	2.2	2.9	1.7	-1.3	-1.4
Total locomotion distance, hab. session 1	1.8	2.6	3.3	1.6	-1.5	-1.8
Locomotion velocity, hab. session 1	2.1	3.0	3.2	1.8	-1.8	-1.6
Time in familiar zone, hab. session 2	1.0	1.0	1.5	-0.6	1.2	1.0
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.1	-0.7	-0.5
Total zone transitions, hab. session 2	0.5	0.6	0.9	0.6	-1.0	-0.7
Total locomotion distance, hab. session 2	1.0	1.3	2.1	0.9	-1.1	-1.4
Locomotion velocity, hab. session 2	1.2	1.6	2.1	1.1	-1.3	-1.5
Novel to familiar place preference ratio	1.5	1.6	2.8	-1.7	0.8	1.1
Novelty place preference	1.5	1.5	2.9	-1.7	0.8	1.1
Time in novel zone, NPP test	2.1	2.1	3.7	-1.9	1.0	1.3
Total zone transitions, NPP test	1.7	2.4	2.8	1.4	-1.5	-1.7
Total locomotion distance, NPP test	1.5	2.0	2.4	1.2	-1.5	-1.5
Locomotion velocity, NPP test	2.4	3.4	4.1	1.7	-2.0	-1.8
Intraocular pressure	0.4	0.6	1.0	0.9	0.0	-1.0
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.6	-0.6	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.6	-0.6	-0.1
Parametrial fat weight	0.1	0.1	0.3	-0.1	0.2	0.5
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.0	0.3	0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.4	0.6	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	0.3	-0.5
Pavlov. Cond. index score	0.3	0.4	0.6	-0.8	0.7	0.4
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.7	0.6	0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	-0.2	-0.1
Pavlov. Cond. magazine entry number	1.1	1.4	2.2	1.2	-1.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.7	0.4	0.2
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	0.4	0.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.2	-0.5	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.8	-0.5	-0.5
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	-0.8	0.7	0.3
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.2	0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	0.1	-0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.5	0.7	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.0	0.0
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.6	1.1	-0.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	0.1	-0.1
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.1	0.2	0.3
Time in closed arm before self-admin	2.0	2.2	3.5	-1.9	1.5	1.0
Time in closed arm after self-admin	0.1	0.1	0.3	-0.3	0.5	0.2
Time in open arm before self-admin	1.7	1.8	3.3	1.8	-0.8	-1.3
Time in open arm after self-admin	0.3	0.4	0.6	-0.7	0.2	0.8
Bone: periosteal estimation	0.1	0.2	0.2	-0.4	-0.5	0.2
Bone: periosteal perimeter	0.1	0.2	0.4	-0.6	-0.4	0.3
Bone: post-yield work	0.2	0.3	0.4	0.5	-0.6	-0.4
Progressive ratio test 1 active lever presses	1.0	1.1	2.1	0.8	-0.7	-1.5
Progressive ratio test 1 breakpoint	1.0	1.0	1.9	0.8	-0.6	-1.4
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.0	0.8	-1.0	-0.6
Progressive ratio test 2 active lever presses	0.7	0.8	1.4	0.7	-0.7	-1.2
Progressive ratio test 2 breakpoint	1.4	1.6	2.5	1.0	-1.1	-1.6
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.5	0.7	-0.5	-0.7
Incentive Sensitization - Responses	0.4	0.4	0.5	0.7	-0.7	-0.6
Incentive Sensitization - Breakpoint	0.7	0.7	0.9	0.9	-0.9	-0.8
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.1	-1.1	1.0	1.5
Progressive ratio	0.2	0.2	0.4	-0.5	0.7	-0.2
Food seeking constrained by brief footshock	0.5	0.6	1.4	0.4	-1.2	-0.4
Seeking ratio, punishment vs. effort	0.5	0.6	1.3	0.6	-1.2	0.1
Retroperitoneal fat weight	1.0	3.2	3.9	1.7	-2.0	-1.7
Reaction time number correct	0.8	1.1	1.9	1.2	-0.2	-1.4
Reaction time mean minus median	1.3	1.8	2.7	-1.2	1.1	1.6
Reaction time mean minus median AUC	0.6	0.8	1.1	-0.8	0.8	1.1
Reaction time num false alarms	0.9	1.3	1.7	1.1	-1.0	-1.3
Reaction time num false alarms AUC	1.3	1.7	1.9	1.4	-1.2	-1.4
Reaction time trials correct on left	0.8	1.1	1.9	1.2	-0.2	-1.4
Reaction time trials on left	0.7	1.0	1.7	1.1	-0.1	-1.3
Reaction time mean	2.9	4.0	4.1	-2.0	2.0	2.0
Reaction time mean AUC	2.6	3.4	4.1	-1.8	2.0	1.7
Median of all reaction times	2.8	3.9	4.5	-2.0	2.1	1.8
Reaction time omissions	0.7	1.0	1.5	-0.7	0.9	1.2
Reaction time false alarm rate	0.4	0.6	1.0	0.7	-1.0	-0.5
Reaction time premature initiation rate	0.1	0.1	0.1	-0.3	-0.3	-0.1
Reaction time premature initiations	0.2	0.3	0.6	0.3	-0.4	-0.7
Std. dev. reaction times	2.2	3.1	4.4	-1.6	1.5	2.1
Reaction time trials completed	0.7	1.0	1.7	1.1	-0.1	-1.3
Reaction time trials AUC	0.6	0.9	1.5	1.1	-0.0	-1.2
Run reversals in cocaine runway, females	0.4	0.3	0.5	0.5	-0.7	-0.6
Run reversals in cocaine runway, males	0.6	0.5	1.0	0.8	-0.0	-1.0
Latency to leave start box in cocaine runway	3.0	3.3	3.4	1.9	-1.8	-1.8
Latency to leave start box in cocaine runway, F	1.2	1.4	1.9	1.3	-1.4	-0.6
Latency to leave start box in cocaine runway, M	2.2	2.1	3.7	1.3	-0.9	-1.9
Std. dev. time between licks in bursts	0.2	0.2	0.4	0.3	-0.7	0.3
Total sessions with >9 infusions	1.3	1.4	3.0	0.9	-0.6	-1.7
Short access day 1 total inactive lever presses	0.6	0.7	1.1	1.1	-0.7	-0.6
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	0.3	0.1
Short access day 1 total infusions	1.0	1.0	1.6	1.1	-0.6	-1.3
Short access day 10 total infusions	0.7	0.8	0.9	-0.8	0.9	-0.9
Short access total infusions	0.5	0.6	1.6	0.1	0.2	-1.3
Short access day 1 locomotion	0.1	0.1	0.2	0.4	-0.2	-0.5
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.3	0.2
Short access total locomotion	0.4	0.4	0.5	0.6	-0.6	-0.7
One hour access (0.3 mA shock)	3.7	4.3	6.0	-2.4	2.2	1.4
Compulsive drug intake	0.8	0.8	1.8	-0.8	0.2	1.3
One hour access (shock baseline)	1.2	1.4	2.2	-1.4	1.5	0.2
Social response proportion	0.5	0.6	1.1	-0.5	1.0	0.7
Social responses	1.1	1.4	3.1	-0.7	1.8	0.8
Social time	3.6	4.7	7.9	-1.8	2.8	1.8
Soleus weight	1.9	5.5	9.8	2.3	-3.1	-1.2
Bone: stiffness	0.9	1.4	1.8	1.1	-1.3	-1.1
Tibialis anterior weight	3.2	11.1	13.5	3.7	-3.3	-2.9
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.1	-0.9	0.8	1.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.7	0.5	0.1
Time to tail flick, test, before self-admin	0.6	0.6	1.2	0.7	-0.1	-1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.1	-0.4	-0.5
Delta time to tail flick, test, before/after SA	1.3	1.2	1.4	-1.2	1.2	0.9
Tibia length	0.1	0.3	0.4	-0.4	-0.6	0.6
Ambulatory time before self-admin	0.2	0.2	0.5	-0.3	0.2	0.7
Ambulatory time after self-admin	0.6	0.6	1.1	1.0	-0.9	0.0
Bone: tissue strength	0.6	0.5	0.9	0.5	-0.7	-0.9
Total heroin consumption	0.8	1.0	1.1	-1.0	1.0	0.9
Bone: trabecular number	1.5	2.3	3.3	-1.8	0.8	1.7
Bone: trabecular spacing	1.6	2.1	3.1	1.4	-1.1	-1.8
Bone: trabecular thickness	2.5	3.0	4.3	-2.1	1.0	1.9
Bone: trabecular tissue density	0.4	0.5	0.8	0.9	-0.8	-0.3
Water consumed over 24 hours	0.2	0.2	0.5	-0.1	-0.1	-0.7
Number of responses in last shaping day	0.1	0.1	0.3	0.2	0.5	0.1