Hub : Genes

LOC108351554

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression LOC108351554 0.28 0.19 2.1e-03 0.14 0.18 0.23 0.2 3.5e-03 1.1e-03 1.8e-04 5.0e-04
2 Brain gene expression LOC108351554 0.07 0.04 2.8e-07 0.08 0.08 0.08 0.08 6.3e-08 3.7e-08 4.8e-08 5.7e-08
3 LHb gene expression LOC108351554 0.17 0.1 1.9e-03 0.04 0.07 0.06 0.09 3.9e-02 1.1e-02 1.4e-02 4.3e-03
4 Liver gene expression LOC108351554 0.05 0.03 7.9e-06 0.04 0.03 0.03 0.04 2.2e-05 1.1e-04 2.2e-04 6.3e-05
5 PL gene expression LOC108351554 0.11 0.08 9.6e-09 0.07 0.08 0.08 0.08 3.5e-08 4.4e-09 6.2e-09 7.6e-09
6 BLA gene expression LOC108351554 0.06 0.05 8.3e-03 0.02 0.02 0.02 0.03 4.4e-02 2.9e-02 2.8e-02 1.3e-02
7 PL mRNA stability LOC108351554 0.05 0.04 6.9e-05 0.03 0.04 0.05 0.04 4.6e-04 2.0e-05 3.1e-06 1.5e-05
8 NAcc mRNA stability LOC108351554 0.14 0.12 1.9e-09 0.08 0.09 0.08 0.08 4.1e-09 4.7e-10 9.2e-10 1.6e-09
9 Brain mRNA stability LOC108351554 0.1 0.06 5.5e-08 0.06 0.09 0.07 0.08 2.5e-06 1.6e-08 3.6e-07 3.6e-08
10 NAcc gene expression LOC108351554 0.47 0.17 0.0e+00 0.15 0.15 0.15 0.15 1.6e-17 1.1e-16 5.0e-17 3.6e-17
11 pVTA gene expression LOC108351554 0.18 0.11 1.3e-06 0.09 0.15 0.14 0.13 1.1e-04 3.4e-07 1.5e-06 3.7e-06
12 Adipose gene expression LOC108351554 0.04 0.03 1.5e-04 0 0.02 0.01 0.01 1.4e-01 1.1e-03 1.1e-02 1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density6.711.215.6-4.03.53.3-3.33.73.4-3.23.23.6-3.03.42.4
Area under the delay curve0.91.01.2-1.01.01.1-1.00.91.1-1.10.90.9-0.91.01.0
BMI with tail4.414.118.1-3.43.64.1-3.73.53.8-3.94.13.4-4.23.33.9
BMI without tail0.81.63.6-1.61.11.3-0.71.50.8-1.91.31.4-1.41.10.6
Body weight4.920.323.9-4.44.64.9-4.44.54.4-4.84.34.4-4.84.44.0
Weight adjusted by age0.20.21.10.40.10.4-0.4-0.20.50.10.7-0.2-0.5-0.21.1
Bone surface9.416.621.0-4.64.34.0-4.14.54.1-4.03.84.4-3.64.23.0
Bone volume8.514.418.3-4.34.03.8-3.84.13.9-3.73.74.0-3.43.92.9
Breakpoint value in progressive ratio session0.10.10.3-0.00.40.2-0.00.60.2-0.20.10.6-0.50.5-0.2
Number of licking bursts1.11.32.31.5-1.2-0.91.0-1.5-1.20.8-1.1-1.50.7-1.2-0.6
Context. condit. distance diff. score0.60.71.3-0.80.90.7-0.61.00.4-1.20.41.0-1.01.00.2
Locomotion velocity, session 14.24.55.32.0-2.2-2.22.2-2.1-2.12.1-2.3-2.02.3-2.0-1.9
Locomotion distance, session 13.34.36.02.1-2.1-2.11.9-2.2-1.92.4-1.9-2.12.2-2.1-1.5
Locomotion velocity, session 20.40.51.01.0-0.6-0.70.6-0.6-0.50.7-0.9-0.50.9-0.4-0.7
Locomotion distance, session 23.95.47.72.5-2.3-2.42.1-2.5-2.12.8-2.2-2.42.6-2.2-1.7
Locomotion velocity, session 34.24.97.11.9-2.1-2.42.3-2.0-2.32.0-2.7-1.92.4-1.8-2.5
Locomotion distance, session 32.12.35.70.5-1.3-1.91.7-0.8-1.81.2-1.7-0.81.8-1.0-2.4
Stereotopy head waving bouts, day 30.40.41.11.0-0.6-0.20.0-1.10.00.7-0.0-1.00.1-0.80.7
Stereotopy head waving duration, day 30.30.40.80.8-0.5-0.40.3-0.9-0.20.7-0.7-0.80.5-0.5-0.2
Locomotion velocity, session 72.52.75.31.1-1.6-2.01.9-1.1-1.81.3-1.8-1.11.8-1.4-2.3
Locomotion distance, session 73.44.37.81.5-1.9-2.32.3-1.5-2.31.7-2.6-1.52.2-1.5-2.8
Stereotopy head waving bouts, day 70.50.52.20.10.30.7-0.70.10.8-0.41.3-0.1-0.8-0.11.5
Stereotopy head waving duration, day 70.81.03.2-0.10.71.1-1.00.31.2-0.71.40.2-1.20.31.8
Locomotion velocity, session 80.50.60.91.0-0.8-0.70.9-0.8-0.70.9-0.7-0.80.7-0.8-0.6
Locomotion distance, session 80.91.32.21.1-1.1-1.31.2-1.0-1.31.1-1.5-0.91.2-0.8-1.3
Degree of sensitization distance0.10.10.30.5-0.20.10.0-0.40.00.2-0.2-0.4-0.1-0.20.4
Degree of sensitization stereotypy0.70.82.8-0.20.50.9-0.80.40.9-0.71.60.2-1.10.11.7
Conditioned locomotion0.00.00.20.1-0.1-0.30.0-0.1-0.20.1-0.40.00.20.1-0.4
Cocaine response after cond. corrected0.10.10.30.5-0.3-0.10.0-0.5-0.10.4-0.1-0.50.2-0.30.2
Cocaine response after cond. not corrected0.20.30.40.4-0.6-0.50.5-0.6-0.50.5-0.4-0.60.6-0.6-0.3
Cocaine response before conditioning1.11.33.10.3-1.0-1.31.5-0.6-1.40.8-1.4-0.61.4-0.8-1.8
Saline control response0.20.20.8-0.90.3-0.0-0.00.7-0.1-0.50.10.6-0.10.4-0.5
Bone: connectivity density3.65.68.4-2.92.52.2-2.32.72.4-2.22.02.7-2.02.61.5
Bone: cortical apparent density0.91.22.71.3-1.1-0.90.6-1.4-0.41.6-0.4-1.41.0-1.3-0.0
Bone: cortical area5.88.811.2-3.33.13.0-2.93.22.9-2.92.93.2-2.73.02.2
Bone: cortical porosity0.40.40.9-1.00.70.2-0.40.90.2-0.60.11.0-0.20.8-0.4
Bone: cortical porosity0.20.20.5-0.70.4-0.1-0.10.7-0.1-0.3-0.20.70.10.6-0.6
Bone: cortical thickness1.62.63.8-1.91.71.7-1.51.81.5-1.51.61.7-1.61.71.2
Bone: cortical thickness0.20.20.6-0.3-0.3-0.40.60.0-0.60.3-0.4-0.00.6-0.2-0.8
Bone: cortical tissue density1.11.43.11.5-1.2-1.10.8-1.5-0.51.8-0.6-1.51.1-1.4-0.2
Condit. Reinf. active minus inactive responses0.00.00.10.2-0.2-0.20.2-0.1-0.30.4-0.0-0.10.3-0.20.0
Condit. Reinf. active-inactive response ratio0.30.30.7-0.60.60.3-0.50.80.3-0.40.30.8-0.20.70.1
Condit. Reinf. active responses0.70.81.21.0-1.0-0.80.9-1.0-0.91.1-0.7-1.00.9-1.0-0.4
Condit. Reinf. inactive responses3.33.95.72.1-2.1-1.81.9-2.4-1.72.1-1.7-2.31.8-2.2-1.0
Incentive salience index mean0.10.10.30.00.10.2-0.10.10.10.00.50.0-0.3-0.00.6
Condit. Reinf. lever presses0.50.62.2-0.10.60.8-0.80.40.9-0.51.10.3-1.00.31.5
Condit. Reinf. active minus inactive responses1.11.31.9-1.11.11.2-1.21.01.2-1.11.30.9-1.30.91.4
Condit. Reinf. active-inactive response ratio0.91.01.2-1.11.01.1-1.00.91.1-1.01.00.9-1.00.91.1
Condit. Reinf. active responses0.20.20.7-0.40.40.4-0.40.40.4-0.40.80.3-0.70.20.7
Condit. Reinf. inactive responses0.60.81.20.9-1.0-1.01.0-0.8-1.01.0-0.4-0.90.7-1.1-0.6
Condit. Reinf. lever presses0.10.10.3-0.40.20.10.00.30.0-0.3-0.30.4-0.10.4-0.5
Condit. Reinf. lever reinforcers received0.00.00.1-0.20.00.1-0.00.1-0.0-0.10.30.1-0.3-0.00.2
Conditioned reinforcement - actives1.31.31.61.2-1.2-1.11.1-1.3-1.11.2-1.0-1.21.2-1.2-0.9
Conditioned reinforcement - inactives1.61.82.31.2-1.3-1.41.5-1.2-1.51.5-1.2-1.21.3-1.3-1.4
Conditioned locomotion0.10.20.70.4-0.3-0.40.4-0.4-0.30.2-0.8-0.20.5-0.1-0.6
Patch foraging indifference point 0 sec4.47.110.12.2-2.7-3.13.0-2.1-3.22.6-2.3-2.22.8-2.6-2.8
Patch foraging indifference point AUC0.40.51.21.1-0.7-0.50.5-0.9-0.40.8-0.2-0.90.6-0.90.1
Delay disc. indifference point, 0s delay1.61.82.2-1.31.41.4-1.51.31.5-1.31.31.3-1.11.31.2
Delay disc. indifference point, 16s delay0.90.91.4-1.11.01.0-0.91.00.9-1.20.81.0-0.91.00.7
Delay disc. indifference point, 2s delay1.61.75.0-0.91.01.4-1.50.61.4-1.12.00.5-1.40.52.2
Delay disc. indifference point, 24s delay0.60.51.1-0.80.70.8-0.60.50.8-1.10.60.6-0.80.70.8
Delay disc. indifference point, 4s delay1.01.01.3-1.11.01.1-1.10.91.1-1.01.00.9-0.90.91.0
Delay disc. indifference point, 8s delay1.51.52.2-1.51.41.3-1.11.31.2-1.40.81.4-1.11.50.7
Indifference point function ln k4.96.99.4-3.12.72.5-2.72.72.6-2.72.32.7-2.62.72.0
Indifference point function log k4.96.99.4-3.12.72.5-2.72.72.6-2.72.32.7-2.62.72.0
Patch foraging total patch changes 0 sec4.06.59.32.0-2.5-3.02.9-1.9-3.12.4-2.4-2.02.7-2.4-2.9
Patch foraging total patch changes 12 sec5.26.78.22.6-2.7-2.72.8-2.4-2.92.6-2.3-2.52.6-2.6-2.3
Patch foraging total patch changes 18 sec6.38.19.72.7-2.9-3.13.1-2.6-3.02.8-2.6-2.73.0-2.8-2.7
Patch foraging total patch changes 24 sec3.44.25.51.8-2.1-2.22.3-1.8-2.31.9-1.9-1.82.2-2.0-2.0
Patch foraging total patch changes 6 sec6.19.011.12.9-3.1-3.33.3-2.7-3.33.1-2.7-2.82.9-3.0-2.7
Patch foraging time to switch 0 sec2.03.14.41.8-2.0-1.82.0-1.8-2.01.6-1.3-1.91.5-2.1-1.4
Patch foraging water rate 0 sec3.45.46.8-2.62.52.4-2.32.42.3-2.51.82.5-2.12.61.7
Patch foraging water rate 12 sec2.53.85.6-2.42.11.9-2.02.11.9-1.91.42.2-1.72.21.3
Patch foraging water rate 18 sec0.30.40.9-0.80.70.6-0.90.60.8-0.30.30.6-0.40.80.5
Patch foraging water rate 24 sec3.75.16.8-2.32.42.3-2.62.22.6-2.02.02.2-2.12.32.0
Patch foraging water rate 6 sec5.88.412.4-3.53.12.9-2.93.02.9-3.02.33.0-2.73.12.1
Seeking ratio, delayed vs. immediate footshock0.70.81.0-0.90.90.9-1.00.80.9-0.91.00.8-0.90.81.0
Distance traveled before self-admin2.22.32.91.7-1.6-1.61.6-1.5-1.71.4-1.4-1.51.3-1.6-1.4
Distance traveled after self-admin0.60.61.60.6-0.7-0.90.7-0.6-0.80.6-1.3-0.50.8-0.4-1.2
Extensor digitorum longus weight4.115.930.1-3.23.54.4-4.13.04.3-3.45.42.7-4.52.65.5
Bone: elastic displacement7.38.313.02.8-2.7-3.12.9-2.6-2.73.0-3.6-2.43.1-2.2-3.2
Bone: elastic work0.20.31.40.1-0.0-0.40.2-0.1-0.00.5-1.20.10.70.4-0.9
Bone: endosteal estimation7.215.618.6-4.34.23.9-4.04.33.9-4.13.64.3-3.54.22.8
Bone: endosteal perimeter6.814.016.2-4.03.93.9-3.73.93.8-3.93.63.8-3.63.72.9
Epididymis fat weight0.30.81.9-0.80.90.5-0.01.3-0.0-1.0-0.61.4-0.31.4-1.0
Delta time in closed arm before/after self-admin0.10.10.2-0.30.40.3-0.40.50.2-0.40.20.5-0.30.50.1
Delta time in open arm before/after self-admin2.82.75.41.1-1.4-1.81.9-1.2-1.71.6-2.2-1.11.8-1.1-2.3
Diff in mean of infusions in LGA sessions1.61.72.8-0.91.21.3-1.21.21.3-1.41.71.1-1.61.01.5
Delay discount exponential model param0.90.91.11.0-1.0-1.11.0-0.8-1.01.0-0.9-0.80.9-0.9-1.0
Extinction: sum of active levers before priming1.11.12.3-0.90.91.1-0.90.90.6-1.11.30.8-1.50.81.3
Active lever presses in extinction session 60.00.00.1-0.20.30.2-0.10.30.1-0.00.00.3-0.10.3-0.0
Bone: final force10.617.122.3-4.74.54.1-4.14.64.0-4.13.64.6-3.64.52.9
Bone: final moment12.019.525.3-5.04.84.4-4.44.94.3-4.43.74.9-3.84.93.0
Food consumed during 24 hour testing period2.32.84.5-2.01.91.5-1.62.01.3-1.90.92.0-1.42.10.8
Glucose0.10.10.50.0-0.4-0.40.6-0.2-0.70.1-0.1-0.30.2-0.5-0.3
Heart weight0.20.31.1-1.00.50.3-0.40.80.4-0.60.40.7-0.30.6-0.0
Delay discount hyperbolic model param1.01.01.41.0-1.0-1.11.1-0.8-1.11.0-1.1-0.81.0-0.9-1.2
Intermittent access intake day 1-15 change0.20.21.00.1-0.1-0.40.40.1-0.40.4-0.70.10.50.1-1.0
Intermittent access intake escalation0.20.20.8-0.30.2-0.10.00.5-0.00.1-0.60.50.30.5-0.9
Intermittent access intake escalation 20.10.10.7-0.10.1-0.30.20.3-0.20.2-0.40.40.30.2-0.8
Intermitt. access day 1 inactive lever presses0.20.20.60.4-0.4-0.50.5-0.3-0.50.6-0.5-0.30.5-0.4-0.7
Intermitt. access day 15 inactive lever presses0.10.10.6-0.0-0.2-0.30.2-0.2-0.20.3-0.7-0.10.4-0.0-0.7
Intermitt. access escalation Index1.41.23.01.7-1.2-0.90.8-1.4-0.81.1-0.4-1.40.8-1.4-0.0
Intermittent access day 1 total infusions1.21.41.81.1-1.2-1.21.1-1.1-1.21.3-1.1-1.11.3-1.1-1.2
Intermittent access day 15 total infusions1.61.83.31.1-1.2-1.41.3-1.0-1.41.4-1.6-0.91.5-1.0-1.8
Intermittent access terminal intake (last 3 days)1.61.72.61.3-1.2-1.41.2-1.1-1.41.4-1.4-1.01.5-1.1-1.6
Intermittent access total infusions1.51.62.51.2-1.2-1.31.2-1.0-1.31.4-1.4-1.01.4-1.0-1.6
Intermittent access day 1 locomotion1.41.42.61.0-1.1-1.31.1-1.0-1.21.2-1.6-0.91.4-0.8-1.6
Intermittent access day 15 total locomotion0.80.93.00.4-0.7-0.91.0-0.4-1.00.6-1.4-0.31.1-0.3-1.7
Intermittent access total locomotion3.33.75.81.6-1.8-2.02.0-1.6-2.01.8-2.3-1.52.1-1.5-2.4
Intermittent access standard deviation0.20.20.7-0.30.3-0.1-0.10.60.10.2-0.40.60.20.6-0.9
Left kidney weight1.23.54.6-2.22.01.8-1.72.11.6-2.01.82.1-1.71.91.3
Right kidney weight2.36.47.6-2.62.52.6-2.42.62.3-2.72.82.5-2.62.32.4
Cocaine induced anxiety1.11.32.4-1.51.21.0-0.91.40.9-1.30.81.4-0.91.30.4
Post-drug Anxiety5.56.18.9-3.02.52.4-2.32.62.3-2.82.22.6-2.42.51.7
Baseline Anxiety0.70.70.9-0.80.80.8-0.90.70.9-0.90.80.7-0.90.80.9
Tail length0.10.40.9-1.00.40.20.10.8-0.1-0.9-0.10.7-0.00.6-0.9
Length with tail1.66.07.4-2.72.72.6-2.42.62.3-2.62.02.7-2.32.71.6
Length without tail3.88.29.7-2.73.03.1-3.12.73.0-2.62.72.7-2.92.92.8
Times rat made contact with spout0.10.10.5-0.70.20.20.10.5-0.1-0.60.00.4-0.20.3-0.2
Lifetime Intake2.12.44.11.4-1.4-1.61.6-1.2-1.71.6-1.9-1.11.7-1.1-2.0
Liver weight, left1.82.94.1-2.01.91.7-1.62.01.5-1.81.32.0-1.52.00.9
Liver weight, right1.93.14.8-2.22.01.6-1.62.21.4-1.81.22.2-1.52.10.8
Locomotor activity0.71.11.80.6-1.2-1.11.2-1.0-1.30.8-1.1-1.10.8-1.1-1.0
Locomotor testing distance2.13.55.21.3-2.0-2.02.2-1.7-2.31.7-1.9-1.71.7-1.9-2.0
Locomotor testing rearing1.11.73.20.4-1.4-1.51.8-0.8-1.80.9-1.1-0.91.3-1.3-1.8
Locomotion in novel chamber2.83.44.3-2.01.82.0-1.81.71.9-2.02.11.6-2.01.51.9
Locomotion in novel chamber post-restriction0.60.71.3-0.91.00.7-0.81.00.7-0.90.21.1-0.71.20.1
Fecal boli incidents, locomotor time 10.70.82.20.7-0.6-0.91.0-0.4-1.00.6-1.5-0.30.8-0.2-1.5
Change in fecal boli incidents, locomotor task0.10.10.7-0.10.10.4-0.4-0.10.40.10.6-0.2-0.1-0.10.8
Time >=10cm from walls, locomotor time 10.30.30.70.5-0.5-0.60.7-0.4-0.70.3-0.8-0.40.7-0.3-0.8
Bouts of movement, locomotor time 10.00.00.20.4-0.10.0-0.1-0.3-0.10.20.0-0.30.0-0.20.3
Total resting periods, locomotor time 10.60.61.21.1-0.8-0.70.6-1.0-0.81.0-0.7-0.90.8-0.8-0.3
Rest time, locomotor task time 10.70.81.10.9-0.9-0.90.8-0.9-1.01.0-0.8-0.90.9-0.9-0.7
Distance moved, locomotor task time 10.00.00.10.2-0.2-0.10.1-0.30.00.00.0-0.30.1-0.30.1
Vertical activity count, locomotor time 10.91.01.5-0.90.91.0-1.00.91.0-1.11.20.8-1.20.81.0
Time >=10cm from walls, locomotor time 20.40.40.70.5-0.5-0.70.7-0.5-0.60.7-0.7-0.40.8-0.4-0.8
Bouts of movement, locomotor time 22.93.13.8-1.71.91.9-1.81.71.7-1.91.71.7-1.61.81.6
Total resting periods, locomotor time 23.33.54.1-1.81.92.0-2.01.81.8-2.02.01.7-1.81.81.9
Rest time, locomotor task time 20.10.10.30.4-0.4-0.30.2-0.5-0.50.5-0.2-0.50.2-0.4-0.1
Distance moved, locomotor task time 20.10.10.20.5-0.4-0.40.3-0.4-0.10.4-0.2-0.40.3-0.4-0.2
Vertical activity count, locomotor time 20.10.10.1-0.20.30.2-0.30.30.4-0.30.30.3-0.40.20.3
Light reinforcement 10.91.73.41.8-1.3-1.11.1-1.5-1.11.4-1.2-1.41.1-1.3-0.7
Light reinforcement 20.00.00.10.30.00.2-0.2-0.20.2-0.10.2-0.1-0.2-0.10.4
Bone: marrow area6.814.717.8-4.24.13.8-3.94.23.8-4.03.54.2-3.44.12.7
Bone: maximum diameter1.73.24.0-2.01.81.8-1.61.91.7-1.91.91.9-1.71.71.3
Bone: maximum force12.521.524.7-4.95.04.7-4.94.94.8-4.54.24.9-4.24.93.7
Bone: maximum moment14.124.328.3-5.35.34.9-5.25.25.1-4.84.45.3-4.45.33.8
Mean time between licks in bursts0.40.61.51.2-0.5-0.60.2-1.0-0.21.0-1.2-0.70.8-0.3-0.4
Mean num. licks in bursts0.91.12.9-1.71.10.6-0.61.60.8-1.00.71.5-0.41.20.0
Cd content in liver0.40.50.80.8-0.6-0.70.7-0.6-0.70.7-0.9-0.60.7-0.5-0.8
Co content in liver0.10.20.6-0.0-0.4-0.10.8-0.0-0.8-0.2-0.1-0.2-0.0-0.4-0.4
Cu content in liver0.50.61.6-1.30.70.6-0.51.10.4-1.00.90.9-0.60.60.2
Fe content in liver0.91.11.31.1-1.1-0.91.2-1.0-1.10.9-1.0-1.00.9-1.1-1.1
K content in liver0.00.00.1-0.2-0.2-0.30.3-0.1-0.30.2-0.1-0.20.2-0.2-0.1
Mg content in liver0.20.20.30.3-0.5-0.50.4-0.5-0.50.5-0.6-0.50.4-0.4-0.2
Mn content in liver0.10.10.5-0.30.30.3-0.40.30.3-0.30.60.2-0.40.20.7
Na content in liver0.10.10.4-0.3-0.4-0.20.6-0.1-0.60.00.1-0.30.2-0.6-0.3
Rb content in liver1.51.83.00.8-1.4-1.51.6-1.0-1.71.3-1.3-1.11.4-1.2-1.6
Se content in liver1.82.23.11.8-1.6-1.41.7-1.5-1.61.3-1.3-1.51.3-1.5-1.1
Sr content in liver0.20.10.4-0.50.30.0-0.10.60.0-0.3-0.10.60.00.5-0.5
Zn content in liver2.32.53.61.7-1.5-1.61.6-1.5-1.81.5-1.9-1.41.5-1.3-1.6
Bone: minimum diameter7.313.615.4-3.73.93.8-3.93.83.9-3.73.43.8-3.43.83.0
Time in familiar zone, hab. session 10.00.00.1-0.10.00.2-0.1-0.20.1-0.1-0.1-0.1-0.10.10.3
Time in novel zone, hab. session 10.00.00.10.30.00.0-0.2-0.00.10.20.2-0.1-0.0-0.10.2
Total zone transitions, hab. session 10.40.61.51.0-0.8-0.30.2-1.2-0.20.90.2-1.20.3-1.10.8
Total locomotion distance, hab. session 10.60.81.50.9-1.0-0.90.6-1.2-0.71.2-0.8-1.11.0-1.0-0.3
Locomotion velocity, hab. session 10.40.51.00.6-0.8-0.70.5-1.0-0.61.0-0.6-0.90.8-0.8-0.1
Time in familiar zone, hab. session 21.71.82.3-1.51.41.3-1.31.41.3-1.51.01.4-1.51.51.0
Time in novel zone, hab. session 22.02.02.91.6-1.5-1.41.3-1.5-1.41.7-1.0-1.51.5-1.6-1.0
Total zone transitions, hab. session 20.40.50.90.9-0.7-0.60.5-0.8-0.50.9-0.6-0.80.8-0.7-0.3
Total locomotion distance, hab. session 20.70.91.71.0-0.9-0.90.7-1.0-0.81.3-1.0-0.91.3-0.8-0.7
Locomotion velocity, hab. session 20.40.51.10.7-0.6-0.60.5-0.7-0.61.0-0.8-0.61.0-0.5-0.6
Novel to familiar place preference ratio1.31.32.9-0.51.01.3-1.20.81.2-0.81.70.7-1.40.61.7
Novelty place preference0.80.82.0-0.20.71.0-1.00.60.9-0.61.40.4-1.10.41.4
Time in novel zone, NPP test0.50.51.7-0.10.50.8-0.80.30.7-0.41.30.2-0.90.21.3
Total zone transitions, NPP test3.14.35.62.1-2.2-2.01.9-2.4-1.92.3-1.8-2.32.2-2.2-1.3
Total locomotion distance, NPP test4.35.87.52.4-2.4-2.42.2-2.6-2.22.7-2.5-2.52.7-2.2-1.9
Locomotion velocity, NPP test2.94.05.42.1-2.0-2.01.8-2.1-1.82.3-2.2-2.02.3-1.8-1.7
Intraocular pressure4.05.67.12.0-2.3-2.72.5-2.0-2.52.7-2.6-1.92.5-2.0-2.6
Delta distance traveled before/after self-admin0.60.71.6-1.30.90.5-0.51.10.5-0.7-0.21.2-0.31.2-0.5
Delta ambulatory time before/after self-admin0.40.51.2-1.00.70.2-0.41.00.4-0.3-0.31.1-0.11.1-0.6
Parametrial fat weight0.81.64.90.9-1.0-1.21.5-0.9-1.40.8-2.2-0.71.2-0.5-2.0
Pavlov. Cond. lever latency0.30.41.30.3-0.4-0.70.5-0.3-0.50.4-1.1-0.20.9-0.1-1.1
Pavlov. Cond. magazine entry latency1.01.32.7-0.41.01.2-1.30.81.1-0.81.60.7-1.40.71.6
Pavlov. Cond. change in total contacts1.51.63.5-0.71.01.4-1.21.01.2-1.11.90.8-1.50.71.9
Pavlov. Cond. index score1.01.33.7-0.60.91.2-1.00.90.9-0.81.90.6-1.50.51.8
Pavlov. Cond. latency score0.91.13.4-0.60.81.1-0.90.80.8-0.81.80.6-1.40.41.6
Pavlov. Cond. lever contacts0.30.31.1-0.30.30.6-0.30.40.3-0.41.00.2-0.80.10.8
Pavlov. Cond. magazine entry number0.50.61.30.2-0.7-0.80.8-0.7-0.60.7-1.2-0.61.0-0.5-1.0
Pavlov. Cond. intertrial magazine entries4.95.97.02.1-2.4-2.62.5-2.3-2.52.6-2.6-2.22.6-2.2-2.3
Pavlov. Cond. lever-magazine prob. diff.1.31.63.9-0.71.01.4-1.21.01.1-1.02.00.8-1.60.71.9
Pavlov. Cond. response bias0.40.41.0-0.10.60.7-0.70.60.6-0.61.00.4-0.90.40.9
Pavlov. Cond. lever latency0.71.02.1-0.81.00.9-1.20.91.1-0.61.50.8-0.80.71.3
Pavlov. Cond. magazine entry latency0.30.31.70.6-0.3-0.20.4-0.5-0.30.3-1.3-0.30.40.1-0.9
Pavlov. Cond. change in total contacts0.50.71.8-0.30.61.1-0.80.40.7-0.91.10.4-1.30.41.3
Pavlov. Cond. index score0.40.61.60.9-0.7-0.50.8-0.8-0.70.4-1.3-0.60.5-0.4-1.0
Pavlov. Cond. latency score0.40.51.30.8-0.6-0.40.7-0.7-0.70.4-1.2-0.60.4-0.4-0.9
Pavlov. Cond. lever contacts0.70.92.40.8-0.8-0.81.1-0.9-1.00.6-1.5-0.70.8-0.6-1.4
Pavlov. Cond. magazine entry number0.00.10.4-0.20.0-0.1-0.10.20.00.10.60.00.0-0.20.4
Pavlov. Cond. intertrial magazine entries0.91.23.50.1-0.9-1.41.5-0.1-1.60.5-1.0-0.21.1-0.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.70.7-0.4-0.20.5-0.5-0.40.2-0.9-0.40.1-0.2-0.6
Pavlov. Cond. response bias0.40.62.20.7-0.5-0.50.8-0.6-0.70.4-1.5-0.40.6-0.2-1.2
Time in closed arm before self-admin0.70.81.7-0.50.80.9-0.90.61.2-0.71.20.5-1.00.51.3
Time in closed arm after self-admin0.30.41.20.00.40.6-0.60.20.8-0.40.90.2-0.70.21.1
Time in open arm before self-admin0.20.21.00.4-0.20.2-0.3-0.5-0.0-0.00.6-0.5-0.2-0.51.0
Time in open arm after self-admin0.30.40.50.7-0.6-0.60.5-0.7-0.60.7-0.6-0.70.6-0.6-0.4
Bone: periosteal estimation9.319.323.7-4.94.74.4-4.44.84.3-4.54.14.7-4.04.63.1
Bone: periosteal perimeter8.914.816.8-4.14.04.0-3.93.93.9-3.93.83.9-3.73.83.2
Bone: post-yield work7.410.011.8-3.23.43.2-3.43.43.3-3.02.93.4-2.83.42.4
Progressive ratio test 1 active lever presses7.88.110.22.8-2.7-3.03.0-2.5-3.03.0-3.1-2.43.0-2.4-3.2
Progressive ratio test 1 breakpoint6.66.98.32.6-2.5-2.82.7-2.3-2.82.8-2.8-2.22.8-2.3-2.9
Progressive ratio test 1 inactive lever presses2.12.32.91.6-1.5-1.51.5-1.4-1.61.7-1.6-1.31.5-1.4-1.6
Progressive ratio test 2 active lever presses1.51.73.01.0-1.2-1.31.4-1.0-1.51.2-1.5-0.91.4-1.0-1.7
Progressive ratio test 2 breakpoint1.61.83.01.1-1.3-1.41.5-1.0-1.61.2-1.5-1.01.5-1.1-1.7
Progressive ratio test 2 inactive lever presses1.01.12.70.8-0.9-1.11.1-0.6-1.11.1-1.3-0.61.2-0.7-1.6
Incentive Sensitization - Responses0.60.61.2-1.10.70.8-0.70.80.5-0.80.90.7-0.70.60.6
Incentive Sensitization - Breakpoint0.40.40.9-0.90.60.7-0.60.70.5-0.70.90.6-0.60.40.6
Sum of active levers in priming session hrs 5-60.70.71.01.0-0.8-0.80.7-0.9-0.71.0-0.8-0.90.8-0.8-0.6
Progressive ratio1.21.41.81.3-1.2-1.11.0-1.3-1.21.3-1.3-1.21.3-1.1-1.0
Food seeking constrained by brief footshock1.92.42.91.4-1.6-1.71.6-1.5-1.61.4-1.6-1.41.7-1.5-1.5
Seeking ratio, punishment vs. effort0.10.20.4-0.50.40.3-0.20.50.4-0.60.40.5-0.40.40.2
Retroperitoneal fat weight0.92.86.21.6-1.4-1.61.9-1.2-2.01.3-2.5-1.01.8-0.9-2.3
Reaction time number correct1.62.45.2-2.31.61.1-1.32.11.2-1.41.32.0-1.01.70.4
Reaction time mean minus median3.95.26.71.7-2.5-2.52.6-2.1-2.62.1-2.0-2.22.4-2.4-2.2
Reaction time mean minus median AUC3.03.95.01.6-2.2-2.12.2-1.9-2.11.9-1.5-2.02.0-2.2-1.6
Reaction time num false alarms1.72.33.41.8-1.5-1.61.3-1.8-1.21.6-1.5-1.71.4-1.5-0.9
Reaction time num false alarms AUC2.02.74.12.0-1.7-1.71.3-2.0-1.31.8-1.5-1.91.5-1.7-0.8
Reaction time trials correct on left1.62.45.2-2.31.61.1-1.32.11.2-1.41.32.0-1.01.70.4
Reaction time trials on left1.42.04.7-2.21.50.9-1.12.01.1-1.31.21.9-0.91.60.2
Reaction time mean0.40.51.10.2-0.7-0.80.9-0.5-0.80.5-0.8-0.60.8-0.7-1.0
Reaction time mean AUC0.20.30.7-0.1-0.5-0.50.7-0.3-0.60.3-0.5-0.30.5-0.4-0.8
Median of all reaction times0.00.00.2-0.50.10.00.10.2-0.0-0.2-0.10.2-0.00.2-0.4
Reaction time omissions6.69.111.42.5-3.1-3.23.2-2.7-3.13.2-2.9-2.73.4-2.9-3.1
Reaction time false alarm rate2.73.77.12.7-2.0-1.71.5-2.6-1.42.0-1.6-2.51.5-2.1-0.5
Reaction time premature initiation rate3.85.16.52.2-2.2-2.42.4-1.9-2.42.3-2.4-1.92.5-1.9-2.5
Reaction time premature initiations1.42.04.50.8-1.2-1.71.6-0.6-1.61.4-1.6-0.71.8-0.9-2.1
Std. dev. reaction times3.75.26.21.9-2.5-2.42.5-2.2-2.52.2-2.0-2.32.4-2.5-2.1
Reaction time trials completed1.42.04.7-2.21.50.9-1.12.01.1-1.31.21.9-0.91.60.2
Reaction time trials AUC2.02.96.1-2.51.81.3-1.52.31.4-1.61.52.2-1.31.80.6
Run reversals in cocaine runway, females0.60.61.6-1.30.80.5-0.70.90.7-0.80.30.9-0.40.90.0
Run reversals in cocaine runway, males0.90.92.01.3-1.1-0.90.8-1.1-0.90.8-0.1-1.20.7-1.4-0.1
Latency to leave start box in cocaine runway0.20.30.60.7-0.4-0.1-0.3-0.80.00.60.1-0.80.1-0.60.7
Latency to leave start box in cocaine runway, F2.52.74.52.1-1.8-1.51.1-2.1-1.31.8-1.1-2.11.4-2.0-0.4
Latency to leave start box in cocaine runway, M2.32.22.7-1.41.51.6-1.61.41.6-1.21.51.4-1.61.51.5
Std. dev. time between licks in bursts1.41.72.31.5-1.3-1.31.2-1.3-1.31.2-1.5-1.21.3-1.1-1.2
Total sessions with >9 infusions1.31.52.31.1-1.1-1.21.2-1.0-1.21.3-1.5-1.01.3-0.9-1.5
Short access day 1 total inactive lever presses1.11.31.71.2-1.1-1.21.2-1.0-1.31.1-1.3-0.91.0-0.9-1.2
Short access day 10 total inactive lever presses0.20.20.4-0.50.40.3-0.20.60.3-0.40.20.6-0.30.5-0.2
Short access day 1 total infusions0.50.51.20.6-0.6-0.70.7-0.5-0.90.7-0.8-0.40.8-0.5-1.1
Short access day 10 total infusions2.93.23.91.8-1.7-1.91.7-1.6-1.81.9-1.9-1.52.0-1.5-2.0
Short access total infusions1.61.83.41.2-1.2-1.41.4-1.0-1.51.4-1.6-0.91.5-0.9-1.8
Short access day 1 locomotion0.20.20.30.6-0.4-0.30.4-0.5-0.40.3-0.5-0.40.4-0.4-0.4
Short access day 10 total locomotion0.10.10.30.1-0.3-0.40.3-0.2-0.30.3-0.3-0.20.4-0.3-0.6
Short access total locomotion0.50.50.80.8-0.7-0.80.7-0.7-0.70.7-0.8-0.60.8-0.7-0.9
One hour access (0.3 mA shock)0.10.10.2-0.40.30.4-0.10.30.2-0.50.30.3-0.40.30.2
Compulsive drug intake1.91.92.9-1.21.31.5-1.31.01.4-1.71.31.0-1.61.11.6
One hour access (shock baseline)0.00.00.1-0.30.10.0-0.00.3-0.0-0.00.20.30.00.1-0.2
Social response proportion0.20.20.6-0.50.20.10.30.5-0.4-0.3-0.30.50.20.4-0.8
Social responses3.74.76.92.1-2.3-2.12.4-2.2-2.62.1-1.8-2.22.1-2.3-1.8
Social time0.50.72.0-1.40.90.7-0.71.00.5-0.90.31.1-0.41.1-0.1
Soleus weight1.03.03.9-2.01.81.8-1.71.81.7-1.91.51.8-1.71.81.4
Bone: stiffness16.325.728.9-5.25.35.3-5.45.15.2-5.04.95.1-4.85.14.4
Tibialis anterior weight2.910.025.2-1.82.43.6-3.11.93.3-2.74.61.5-3.91.55.0
Time to tail flick, vehicle, before self-admin0.70.81.41.2-0.9-0.90.9-0.9-1.10.9-0.5-0.90.6-1.0-0.4
Time to tail flick, vehicle, after self-admin0.50.50.9-0.40.70.8-0.60.60.8-0.61.00.6-0.90.50.9
Time to tail flick, test, before self-admin0.30.30.70.5-0.7-0.60.4-0.8-0.40.6-0.1-0.80.5-0.80.1
Time to tail flick, test, after self-admin0.80.81.3-0.91.00.8-0.81.10.9-1.10.91.1-0.91.00.6
Delta time to tail flick, vehicle, before/after SA1.01.01.4-1.11.11.0-0.81.21.0-1.00.71.2-0.81.10.5
Delta time to tail flick, test, before/after SA1.00.91.4-0.81.11.0-0.91.21.0-1.00.81.2-0.91.10.5
Tibia length4.913.718.5-4.34.03.7-3.44.23.4-4.12.84.2-3.54.22.0
Ambulatory time before self-admin3.73.84.52.1-2.0-2.02.1-1.9-2.11.8-2.0-1.91.7-1.9-1.8
Ambulatory time after self-admin1.41.53.60.9-1.0-1.41.3-0.8-1.31.0-1.8-0.71.3-0.7-1.9
Bone: tissue strength1.51.42.0-1.01.21.2-1.41.11.4-1.01.21.1-1.11.21.4
Total heroin consumption1.71.92.9-1.71.51.2-1.11.61.2-1.70.81.7-1.41.70.5
Bone: trabecular number3.96.09.6-3.12.62.3-2.42.92.4-2.42.02.8-2.12.71.4
Bone: trabecular spacing1.01.21.91.3-1.2-1.01.1-1.3-1.21.1-0.8-1.40.8-1.3-0.5
Bone: trabecular thickness0.40.51.1-0.70.60.7-0.80.60.9-0.41.00.5-0.50.40.9
Bone: trabecular tissue density0.50.83.40.50.30.9-1.1-0.41.20.11.0-0.3-0.70.01.9
Water consumed over 24 hours0.30.31.1-0.90.2-0.20.20.6-0.4-0.5-0.60.60.40.5-1.0
Number of responses in last shaping day0.20.20.5-0.10.50.4-0.70.40.7-0.40.40.4-0.40.50.5