LOC108351553

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	LOC108351553	0.03	0.02	3.8e-04	0.01	0.02	0.01	0.01	1.0e-02	2.5e-03	9.9e-03	2.3e-02
2	pVTA	gene expression	LOC108351553	0.05	0.05	9.4e-03	0.02	0.02	0.03	0.02	3.1e-02	3.2e-02	2.2e-02	5.1e-02
3	PL	gene expression	LOC108351553	0.11	0.07	3.4e-15	0.15	0.15	0.16	0.16	4.0e-16	7.4e-16	1.1e-16	9.7e-17
4	NAcc	gene expression	LOC108351553	0.09	0.06	2.4e-12	0.09	0.11	0.1	0.1	1.7e-10	2.3e-12	2.4e-11	3.9e-11
5	Brain	mRNA stability	LOC108351553	0.04	0.04	4.9e-04	0.02	0.01	-0	0	1.0e-02	1.4e-02	6.6e-01	2.3e-01
6	Brain	gene expression	LOC108351553	0.09	0.07	7.1e-06	0.04	0.05	0.04	0.04	6.2e-05	3.6e-05	2.5e-04	9.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	7.2	12.0	14.9	3.9	-3.7	3.5	3.4	-3.4	2.9
Area under the delay curve	1.1	1.2	1.4	1.1	-1.2	1.2	1.1	-1.0	1.0
BMI with tail	4.3	13.9	16.0	3.9	-4.0	3.7	3.7	-3.7	3.3
BMI without tail	0.2	0.4	0.8	0.4	-0.6	0.6	0.7	-0.7	0.9
Body weight	4.7	19.9	23.7	4.9	-4.9	4.5	4.3	-4.3	3.8
Weight adjusted by age	0.3	0.3	0.7	0.8	-0.8	0.5	0.4	-0.4	0.2
Bone surface	9.7	17.1	20.2	4.5	-4.4	4.1	4.0	-4.1	3.6
Bone volume	8.9	15.1	16.8	4.1	-4.1	3.9	3.8	-3.9	3.5
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.3	-0.2	0.3	0.1	-0.0	0.0
Number of licking bursts	1.2	1.4	1.6	-1.2	1.2	-1.2	-1.2	1.2	-1.2
Context. condit. distance diff. score	0.1	0.2	0.3	0.5	-0.4	0.4	0.5	-0.4	0.4
Locomotion velocity, session 1	4.1	4.4	5.1	-1.9	2.0	-2.1	-2.2	2.1	-2.3
Locomotion distance, session 1	2.8	3.6	3.9	-2.0	2.0	-1.9	-1.9	1.9	-1.8
Locomotion velocity, session 2	0.3	0.3	0.4	-0.6	0.6	-0.5	-0.6	0.6	-0.5
Locomotion distance, session 2	3.1	4.3	4.8	-2.1	2.2	-2.1	-2.1	2.1	-2.0
Locomotion velocity, session 3	4.6	5.3	5.9	-2.4	2.3	-2.3	-2.3	2.3	-2.2
Locomotion distance, session 3	3.0	3.3	4.4	-2.1	2.0	-1.8	-1.7	1.8	-1.4
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	0.3	-0.3	0.1	-0.0	-0.1	-0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.1	-0.1	-0.1	-0.3	0.2	-0.5
Locomotion velocity, session 7	3.0	3.3	4.1	-1.6	1.7	-1.8	-1.9	1.8	-2.0
Locomotion distance, session 7	4.2	5.3	5.5	-2.2	2.3	-2.3	-2.3	2.3	-2.3
Stereotopy head waving bouts, day 7	0.6	0.6	0.7	0.8	-0.8	0.9	0.7	-0.9	0.7
Stereotopy head waving duration, day 7	1.2	1.4	1.6	1.2	-1.3	1.2	1.1	-1.2	1.0
Locomotion velocity, session 8	0.4	0.5	0.8	-0.5	0.6	-0.7	-0.8	0.7	-0.9
Locomotion distance, session 8	1.2	1.8	2.3	-1.3	1.5	-1.4	-1.3	1.3	-1.2
Degree of sensitization distance	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.0	0.0	-0.2
Degree of sensitization stereotypy	0.7	0.8	1.0	0.7	-0.8	0.9	0.9	-1.0	1.0
Conditioned locomotion	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.1	0.1	-0.2
Cocaine response after cond. corrected	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1	0.0
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.6	0.4	-0.5	-0.4	0.5	-0.3
Cocaine response before conditioning	1.9	2.3	3.1	-1.8	1.7	-1.5	-1.5	1.5	-1.2
Saline control response	0.0	0.0	0.0	0.1	0.0	-0.1	-0.1	0.1	-0.2
Bone: connectivity density	3.8	6.0	8.1	2.8	-2.7	2.4	2.3	-2.4	1.8
Bone: cortical apparent density	0.2	0.2	0.3	-0.6	0.3	-0.4	-0.5	0.4	-0.4
Bone: cortical area	5.7	8.6	11.0	3.3	-3.3	2.9	2.8	-2.8	2.4
Bone: cortical porosity	0.1	0.1	0.2	-0.1	-0.0	0.2	0.3	-0.2	0.5
Bone: cortical porosity	0.0	0.0	0.1	-0.3	0.3	-0.1	0.0	0.1	0.3
Bone: cortical thickness	1.5	2.5	3.4	1.8	-1.8	1.5	1.5	-1.5	1.2
Bone: cortical thickness	0.3	0.3	0.6	-0.4	0.5	-0.7	-0.6	0.6	-0.7
Bone: cortical tissue density	0.2	0.3	0.5	-0.7	0.5	-0.6	-0.6	0.5	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.3	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	-0.4	0.3	0.4	-0.3	0.3
Condit. Reinf. active responses	0.8	0.9	1.0	-1.0	1.0	-1.0	-1.0	1.0	-0.9
Condit. Reinf. inactive responses	2.8	3.3	3.8	-1.9	1.9	-1.8	-1.8	1.8	-1.6
Incentive salience index mean	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.0
Condit. Reinf. lever presses	0.4	0.6	0.8	0.7	-0.7	0.7	0.8	-0.8	0.9
Condit. Reinf. active minus inactive responses	1.0	1.2	1.9	0.8	-0.9	1.1	1.2	-1.2	1.4
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.8	0.5	-0.6	1.0	1.0	-1.1	1.3
Condit. Reinf. active responses	0.1	0.1	0.4	0.1	-0.2	0.4	0.4	-0.4	0.6
Condit. Reinf. inactive responses	0.8	1.0	1.1	-1.0	0.9	-1.0	-1.0	1.0	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	0.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.0	0.1	0.2
Conditioned reinforcement - actives	1.0	1.0	1.4	-1.2	1.2	-0.9	-1.0	1.0	-0.8
Conditioned reinforcement - inactives	1.8	2.1	2.6	-1.6	1.6	-1.3	-1.4	1.3	-1.3
Conditioned locomotion	0.1	0.1	0.3	-0.5	0.5	-0.2	-0.3	0.4	-0.2
Patch foraging indifference point 0 sec	6.2	10.0	11.1	-3.0	3.2	-3.3	-3.1	3.1	-3.2
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.6	0.5	-0.4	-0.4	0.3	-0.3
Delay disc. indifference point, 0s delay	2.1	2.3	2.6	1.5	-1.5	1.5	1.5	-1.6	1.5
Delay disc. indifference point, 16s delay	0.9	1.0	1.3	1.0	-0.9	1.2	1.0	-0.9	0.9
Delay disc. indifference point, 2s delay	1.9	2.1	2.4	1.5	-1.5	1.3	1.5	-1.4	1.4
Delay disc. indifference point, 24s delay	0.6	0.6	0.8	0.9	-0.9	0.7	0.7	-0.7	0.6
Delay disc. indifference point, 4s delay	1.2	1.3	1.7	1.0	-1.1	1.3	1.1	-1.1	1.2
Delay disc. indifference point, 8s delay	1.4	1.5	1.9	1.4	-1.4	1.3	1.2	-1.0	1.0
Indifference point function ln k	5.0	6.9	7.9	2.7	-2.8	2.6	2.6	-2.6	2.4
Indifference point function log k	5.0	6.9	7.9	2.7	-2.8	2.6	2.6	-2.6	2.4
Patch foraging total patch changes 0 sec	5.8	9.3	10.3	-2.9	3.1	-3.2	-3.0	3.0	-3.1
Patch foraging total patch changes 12 sec	6.1	7.9	8.5	-2.7	2.9	-2.9	-2.8	2.8	-2.8
Patch foraging total patch changes 18 sec	7.4	9.5	10.6	-3.1	3.3	-3.1	-3.1	3.0	-2.9
Patch foraging total patch changes 24 sec	4.6	5.6	6.0	-2.3	2.4	-2.4	-2.4	2.3	-2.3
Patch foraging total patch changes 6 sec	7.0	10.4	11.4	-3.1	3.2	-3.4	-3.2	3.2	-3.2
Patch foraging time to switch 0 sec	2.3	3.6	4.2	-2.0	2.0	-1.8	-1.9	1.9	-1.8
Patch foraging water rate 0 sec	3.1	5.0	5.4	2.3	-2.3	2.2	2.3	-2.2	2.1
Patch foraging water rate 12 sec	2.5	3.9	5.1	2.2	-2.2	1.9	2.0	-1.8	1.7
Patch foraging water rate 18 sec	0.4	0.5	0.6	0.8	-0.8	0.6	0.8	-0.7	0.7
Patch foraging water rate 24 sec	4.6	6.5	6.9	2.6	-2.6	2.6	2.6	-2.4	2.4
Patch foraging water rate 6 sec	5.3	7.8	8.2	2.9	-2.8	2.8	2.9	-2.7	2.7
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.9	0.8	-0.8	0.8	0.9	-0.9	0.9
Distance traveled before self-admin	2.6	2.8	3.0	-1.6	1.7	-1.7	-1.7	1.7	-1.6
Distance traveled after self-admin	0.6	0.7	1.0	-0.7	1.0	-0.9	-0.8	0.8	-0.8
Extensor digitorum longus weight	4.7	18.5	20.4	4.4	-4.5	4.4	4.2	-4.3	4.0
Bone: elastic displacement	6.5	7.3	7.7	-2.7	2.6	-2.8	-2.8	2.7	-2.7
Bone: elastic work	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1	-0.1
Bone: endosteal estimation	7.1	15.4	18.1	4.3	-4.1	3.9	3.9	-3.9	3.5
Bone: endosteal perimeter	6.7	13.9	15.5	3.9	-3.9	3.7	3.7	-3.7	3.4
Epididymis fat weight	0.0	0.0	0.1	0.3	-0.2	0.1	0.1	-0.1	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.4	-0.3	0.3	0.3	-0.3	0.2
Delta time in open arm before/after self-admin	3.6	3.5	4.1	-2.0	2.0	-1.9	-1.8	1.8	-1.6
Diff in mean of infusions in LGA sessions	1.3	1.4	1.9	1.3	-1.4	1.3	1.1	-1.1	0.9
Delay discount exponential model param	1.1	1.2	1.4	-1.1	1.2	-1.2	-1.1	0.9	-1.0
Extinction: sum of active levers before priming	0.6	0.6	0.7	0.9	-0.8	0.8	0.8	-0.8	0.7
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.2	0.3	0.2	-0.1	0.0
Bone: final force	10.4	16.7	19.1	4.4	-4.3	4.1	4.1	-4.0	3.7
Bone: final moment	11.9	19.2	21.5	4.6	-4.6	4.4	4.4	-4.3	4.0
Food consumed during 24 hour testing period	1.5	1.8	2.1	1.5	-1.4	1.3	1.4	-1.3	1.2
Glucose	0.3	0.5	0.8	-0.5	0.6	-0.7	-0.7	0.6	-0.9
Heart weight	0.1	0.1	0.2	0.3	-0.4	0.4	0.3	-0.3	0.3
Delay discount hyperbolic model param	1.2	1.3	1.5	-1.1	1.2	-1.2	-1.1	1.0	-1.1
Intermittent access intake day 1-15 change	0.2	0.2	0.5	-0.7	0.5	-0.2	-0.3	0.3	0.0
Intermittent access intake escalation	0.1	0.1	0.1	-0.4	0.2	0.1	0.1	-0.1	0.4
Intermittent access intake escalation 2	0.1	0.1	0.4	-0.6	0.4	-0.2	-0.2	0.2	0.2
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.7	-0.8	0.7	-0.5	-0.5	0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	-0.5	0.5	-0.1	-0.2	0.1	0.1
Intermitt. access escalation Index	0.9	0.8	1.0	-0.8	0.8	-1.0	-0.9	0.9	-0.9
Intermittent access day 1 total infusions	1.2	1.4	1.7	-1.2	1.3	-1.1	-1.2	1.2	-1.1
Intermittent access day 15 total infusions	1.6	1.8	2.6	-1.6	1.5	-1.2	-1.3	1.3	-1.0
Intermittent access terminal intake (last 3 days)	1.6	1.7	2.6	-1.6	1.5	-1.2	-1.3	1.3	-1.0
Intermittent access total infusions	1.5	1.7	2.5	-1.6	1.5	-1.1	-1.3	1.3	-1.0
Intermittent access day 1 locomotion	1.4	1.5	1.7	-1.2	1.3	-1.1	-1.2	1.2	-1.2
Intermittent access day 15 total locomotion	1.1	1.1	1.5	-1.2	1.2	-1.0	-1.0	1.0	-0.9
Intermittent access total locomotion	3.8	4.3	5.0	-2.2	2.2	-2.0	-2.1	2.0	-1.9
Intermittent access standard deviation	0.0	0.0	0.1	-0.2	0.2	0.2	0.1	-0.1	0.4
Left kidney weight	1.0	2.7	3.0	1.5	-1.7	1.7	1.6	-1.6	1.7
Right kidney weight	2.1	5.8	6.9	2.6	-2.6	2.5	2.3	-2.3	2.1
Cocaine induced anxiety	0.8	1.0	1.2	1.1	-1.0	1.1	0.9	-0.9	0.8
Post-drug Anxiety	5.0	5.6	6.4	2.5	-2.5	2.4	2.3	-2.3	2.1
Baseline Anxiety	0.8	0.8	1.1	1.0	-1.1	0.7	0.9	-0.9	0.8
Tail length	0.0	0.1	0.1	-0.3	0.2	-0.3	-0.2	0.2	-0.0
Length with tail	1.5	5.6	6.9	2.6	-2.6	2.3	2.3	-2.3	2.0
Length without tail	4.6	10.0	13.0	3.6	-3.5	3.2	3.0	-3.0	2.5
Times rat made contact with spout	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.1	0.1	-0.0
Lifetime Intake	2.3	2.6	3.3	-1.8	1.8	-1.4	-1.6	1.6	-1.4
Liver weight, left	1.5	2.4	2.9	1.7	-1.7	1.5	1.5	-1.5	1.3
Liver weight, right	1.3	2.2	2.7	1.6	-1.6	1.4	1.5	-1.4	1.4
Locomotor activity	1.2	1.9	2.1	-1.4	1.4	-1.4	-1.3	1.4	-1.2
Locomotor testing distance	3.2	5.3	5.9	-2.4	2.3	-2.3	-2.3	2.3	-2.1
Locomotor testing rearing	2.2	3.4	3.8	-2.0	1.9	-1.9	-1.8	1.8	-1.6
Locomotion in novel chamber	2.8	3.4	4.1	1.6	-1.7	1.9	1.9	-1.9	2.0
Locomotion in novel chamber post-restriction	0.4	0.5	0.8	0.6	-0.6	0.5	0.8	-0.8	0.9
Fecal boli incidents, locomotor time 1	1.1	1.2	1.7	-1.3	1.2	-1.0	-1.1	1.2	-0.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.8	-0.7	0.5	0.5	-0.4	0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.4	0.5	-0.5	-0.7	0.7	-0.9
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.0
Total resting periods, locomotor time 1	0.4	0.4	0.7	-0.6	0.6	-0.6	-0.6	0.8	-0.7
Rest time, locomotor task time 1	0.8	0.9	1.3	-0.9	0.9	-0.8	-0.9	1.1	-0.9
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.2	-0.1
Vertical activity count, locomotor time 1	1.0	1.1	1.2	1.1	-1.1	1.1	1.0	-1.1	0.8
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.6	-0.7	0.7	-0.3	-0.6	0.5	-0.5
Bouts of movement, locomotor time 2	3.2	3.4	3.9	1.9	-2.0	1.8	1.9	-1.8	1.7
Total resting periods, locomotor time 2	3.7	4.0	4.5	2.0	-2.1	1.9	2.0	-2.0	1.9
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.3	0.1	-0.5	-0.4	0.5	-0.4
Distance moved, locomotor task time 2	0.0	0.1	0.2	-0.2	0.4	-0.0	-0.2	0.1	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.2	-0.1	0.5	0.3	-0.5	0.4
Light reinforcement 1	0.8	1.5	2.5	-1.6	1.5	-1.2	-1.1	1.1	-0.7
Light reinforcement 2	0.1	0.1	0.3	-0.2	0.1	0.1	0.2	-0.2	0.5
Bone: marrow area	6.6	14.4	17.2	4.1	-3.9	3.8	3.8	-3.7	3.4
Bone: maximum diameter	1.5	2.8	3.8	2.0	-1.9	1.6	1.6	-1.6	1.3
Bone: maximum force	13.7	23.7	27.7	5.3	-5.2	4.8	4.8	-4.7	4.3
Bone: maximum moment	15.5	26.8	30.7	5.5	-5.5	5.1	5.1	-5.0	4.6
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	0.2	-0.1	-0.1	0.2	-0.1
Mean num. licks in bursts	0.5	0.6	0.7	0.7	-0.7	0.8	0.8	-0.8	0.9
Cd content in liver	0.5	0.5	0.7	-0.8	0.8	-0.7	-0.7	0.7	-0.5
Co content in liver	0.5	0.6	0.8	-0.9	0.8	-0.7	-0.8	0.7	-0.6
Cu content in liver	0.2	0.2	0.4	0.6	-0.6	0.3	0.4	-0.3	0.2
Fe content in liver	1.0	1.2	1.2	-1.0	1.0	-1.1	-1.1	1.1	-1.1
K content in liver	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.3	0.4	-0.5
Mg content in liver	0.3	0.3	0.3	-0.4	0.5	-0.6	-0.5	0.6	-0.5
Mn content in liver	0.1	0.1	0.1	0.4	-0.4	0.2	0.4	-0.3	0.3
Na content in liver	0.3	0.3	0.4	-0.5	0.5	-0.5	-0.6	0.6	-0.6
Rb content in liver	2.3	2.9	3.2	-1.5	1.6	-1.8	-1.7	1.8	-1.8
Se content in liver	2.1	2.5	2.7	-1.5	1.6	-1.6	-1.6	1.5	-1.6
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	0.0	-0.1	-0.0
Zn content in liver	3.0	3.3	3.7	-1.8	1.9	-1.8	-1.7	1.9	-1.7
Bone: minimum diameter	8.2	15.3	17.6	4.2	-4.2	3.9	3.9	-3.8	3.5
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	0.0	0.2	0.1	-0.2	0.3
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.2	-0.2	0.0	0.1	-0.0	-0.0
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.4	0.4	-0.3	-0.2	0.2	-0.1
Total locomotion distance, hab. session 1	0.3	0.5	0.8	-0.5	0.5	-0.7	-0.7	0.7	-0.9
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.3	0.3	-0.6	-0.5	0.6	-0.7
Time in familiar zone, hab. session 2	1.6	1.7	1.9	1.2	-1.2	1.4	1.3	-1.3	1.4
Time in novel zone, hab. session 2	1.8	1.8	2.2	-1.2	1.2	-1.4	-1.4	1.4	-1.5
Total zone transitions, hab. session 2	0.2	0.3	0.3	-0.6	0.6	-0.6	-0.5	0.6	-0.4
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.6	0.6	-0.8	-0.7	0.8	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.4	-0.5	0.4	-0.6	-0.5	0.6	-0.6
Novel to familiar place preference ratio	1.4	1.4	1.9	1.3	-1.4	1.1	1.2	-1.1	1.0
Novelty place preference	0.8	0.8	1.2	1.0	-1.1	0.8	0.9	-0.8	0.7
Time in novel zone, NPP test	0.5	0.6	0.9	0.9	-0.9	0.7	0.7	-0.7	0.5
Total zone transitions, NPP test	2.7	3.9	4.2	-1.9	2.0	-2.0	-2.0	2.0	-2.0
Total locomotion distance, NPP test	3.6	4.9	5.2	-2.1	2.2	-2.3	-2.2	2.3	-2.2
Locomotion velocity, NPP test	2.4	3.3	3.6	-1.7	1.8	-1.9	-1.8	1.9	-1.9
Intraocular pressure	5.0	6.9	8.7	-3.0	2.9	-2.7	-2.5	2.5	-2.1
Delta distance traveled before/after self-admin	0.2	0.2	0.2	0.4	-0.3	0.4	0.5	-0.5	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.2	-0.2	0.2	0.3	-0.3	0.4
Parametrial fat weight	1.3	2.5	3.3	-1.8	1.8	-1.5	-1.5	1.5	-1.2
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.1	0.3	-0.4	-0.5	0.4	-0.7
Pavlov. Cond. magazine entry latency	0.9	1.2	1.8	0.9	-0.9	1.1	1.2	-1.1	1.3
Pavlov. Cond. change in total contacts	1.3	1.4	2.1	0.9	-1.0	1.2	1.2	-1.2	1.5
Pavlov. Cond. index score	0.7	0.9	1.4	0.7	-0.8	0.9	1.0	-0.9	1.2
Pavlov. Cond. latency score	0.5	0.7	1.2	0.5	-0.7	0.8	0.9	-0.8	1.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.1	-0.1	0.3	0.3	-0.3	0.6
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.4	0.4	-0.6	-0.7	0.6	-0.9
Pavlov. Cond. intertrial magazine entries	4.9	5.9	7.9	-2.0	2.2	-2.5	-2.5	2.5	-2.8
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.8	0.9	-1.0	1.1	1.2	-1.1	1.3
Pavlov. Cond. response bias	0.3	0.3	0.6	0.3	-0.4	0.5	0.6	-0.6	0.8
Pavlov. Cond. lever latency	0.9	1.2	1.6	0.9	-1.0	1.1	1.1	-1.1	1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	0.1	0.1	-0.3	-0.4	0.3	-0.7
Pavlov. Cond. change in total contacts	0.4	0.6	0.9	0.9	-0.8	0.7	0.7	-0.7	0.5
Pavlov. Cond. index score	0.4	0.5	1.2	-0.3	0.5	-0.7	-0.8	0.7	-1.1
Pavlov. Cond. latency score	0.4	0.5	1.1	-0.3	0.5	-0.7	-0.7	0.7	-1.1
Pavlov. Cond. lever contacts	0.8	1.0	1.2	-0.9	1.0	-1.0	-1.1	1.0	-1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.5	0.2	0.0	0.1	-0.0	0.5
Pavlov. Cond. intertrial magazine entries	2.1	2.7	4.1	-2.0	1.9	-1.6	-1.5	1.6	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	0.0	0.2	-0.4	-0.5	0.4	-0.8
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.6	0.7	-0.7	-0.7	0.7	-0.8
Time in closed arm before self-admin	1.0	1.1	1.4	1.2	-1.1	1.0	1.0	-1.1	0.9
Time in closed arm after self-admin	0.4	0.4	0.6	0.8	-0.6	0.7	0.7	-0.7	0.6
Time in open arm before self-admin	0.1	0.1	0.2	0.4	-0.5	0.3	0.2	-0.1	0.0
Time in open arm after self-admin	0.3	0.3	0.4	-0.5	0.5	-0.6	-0.5	0.6	-0.5
Bone: periosteal estimation	9.1	18.7	22.6	4.8	-4.6	4.3	4.3	-4.2	3.8
Bone: periosteal perimeter	9.0	15.0	17.3	4.2	-4.1	3.8	3.8	-3.8	3.4
Bone: post-yield work	8.0	11.0	13.1	3.6	-3.4	3.3	3.3	-3.2	2.9
Progressive ratio test 1 active lever presses	8.3	8.7	9.3	-3.0	3.0	-2.9	-3.0	2.9	-2.9
Progressive ratio test 1 breakpoint	7.0	7.3	7.9	-2.8	2.8	-2.7	-2.7	2.7	-2.6
Progressive ratio test 1 inactive lever presses	2.1	2.3	3.0	-1.7	1.7	-1.4	-1.5	1.4	-1.2
Progressive ratio test 2 active lever presses	2.0	2.1	2.7	-1.6	1.6	-1.4	-1.4	1.4	-1.2
Progressive ratio test 2 breakpoint	2.2	2.5	3.2	-1.8	1.7	-1.6	-1.5	1.5	-1.3
Progressive ratio test 2 inactive lever presses	1.0	1.2	1.9	-1.4	1.3	-1.0	-1.0	1.0	-0.8
Incentive Sensitization - Responses	0.3	0.3	0.5	0.4	-0.5	0.5	0.6	-0.6	0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.3	-0.4	0.4	0.5	-0.5	0.6
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.6	-0.5	0.7	-0.6	-0.7	0.7	-0.8
Progressive ratio	1.0	1.2	1.4	-0.9	1.0	-1.2	-1.1	1.2	-1.2
Food seeking constrained by brief footshock	1.8	2.2	2.5	-1.3	1.4	-1.5	-1.5	1.5	-1.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.3	-0.3	0.4	0.3	-0.4	0.4
Retroperitoneal fat weight	1.1	3.6	4.1	-1.8	2.0	-1.9	-1.9	1.9	-1.9
Reaction time number correct	1.1	1.5	2.2	1.5	-1.3	1.2	1.2	-1.1	1.0
Reaction time mean minus median	5.5	7.3	9.4	-3.1	3.0	-2.7	-2.6	2.6	-2.2
Reaction time mean minus median AUC	4.0	5.2	6.6	-2.6	2.5	-2.2	-2.2	2.2	-1.8
Reaction time num false alarms	1.2	1.7	2.2	-1.5	1.4	-1.2	-1.3	1.2	-1.1
Reaction time num false alarms AUC	1.4	1.9	2.6	-1.6	1.5	-1.3	-1.4	1.3	-1.2
Reaction time trials correct on left	1.1	1.5	2.2	1.5	-1.3	1.2	1.2	-1.1	1.0
Reaction time trials on left	0.8	1.2	1.7	1.3	-1.1	1.1	1.1	-0.9	0.9
Reaction time mean	0.6	0.9	1.1	-1.0	1.0	-0.9	-0.9	0.9	-0.8
Reaction time mean AUC	0.4	0.5	0.6	-0.8	0.7	-0.6	-0.7	0.7	-0.6
Median of all reaction times	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	0.1	-0.1
Reaction time omissions	7.5	10.3	12.6	-3.5	3.5	-3.1	-3.2	3.1	-2.7
Reaction time false alarm rate	1.6	2.2	3.2	-1.8	1.6	-1.4	-1.5	1.3	-1.2
Reaction time premature initiation rate	4.4	5.9	7.5	-2.7	2.7	-2.4	-2.4	2.4	-2.0
Reaction time premature initiations	1.9	2.7	3.5	-1.8	1.9	-1.6	-1.5	1.7	-1.3
Std. dev. reaction times	4.8	6.8	8.2	-2.9	2.8	-2.6	-2.5	2.6	-2.2
Reaction time trials completed	0.8	1.2	1.7	1.3	-1.1	1.1	1.1	-0.9	0.9
Reaction time trials AUC	1.4	2.0	2.8	1.7	-1.5	1.4	1.4	-1.3	1.2
Run reversals in cocaine runway, females	0.5	0.5	0.7	0.6	-0.7	0.8	0.7	-0.7	0.9
Run reversals in cocaine runway, males	0.8	0.8	1.1	-1.0	1.0	-1.1	-0.8	0.8	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.0	0.1	-0.1	0.0	0.1	0.0
Latency to leave start box in cocaine runway, F	1.6	1.7	2.0	-1.4	1.4	-1.3	-1.3	1.3	-1.1
Latency to leave start box in cocaine runway, M	2.3	2.2	2.5	1.6	-1.6	1.5	1.5	-1.5	1.4
Std. dev. time between licks in bursts	1.4	1.7	2.2	-1.3	1.5	-1.3	-1.2	1.3	-1.1
Total sessions with >9 infusions	1.3	1.4	1.9	-1.4	1.3	-1.0	-1.2	1.2	-1.1
Short access day 1 total inactive lever presses	1.2	1.4	1.9	-1.3	1.4	-1.1	-1.1	1.1	-1.0
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.1	-0.1	0.2	0.3	-0.3	0.4
Short access day 1 total infusions	0.6	0.6	0.7	-0.7	0.8	-0.7	-0.8	0.8	-0.9
Short access day 10 total infusions	2.6	2.9	3.2	-1.7	1.8	-1.6	-1.7	1.7	-1.7
Short access total infusions	1.7	1.9	2.0	-1.4	1.4	-1.3	-1.4	1.4	-1.4
Short access day 1 locomotion	0.2	0.2	0.3	-0.5	0.5	-0.4	-0.5	0.5	-0.5
Short access day 10 total locomotion	0.1	0.2	0.2	-0.4	0.5	-0.3	-0.4	0.4	-0.4
Short access total locomotion	0.5	0.5	0.6	-0.8	0.8	-0.6	-0.7	0.7	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.1	-0.1	0.4	0.2	-0.3	0.5
Compulsive drug intake	1.9	1.9	2.2	1.4	-1.5	1.5	1.3	-1.4	1.3
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	0.2	0.1	0.1	-0.1	0.2
Social response proportion	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.3	0.3	-0.2
Social responses	5.3	6.9	8.6	-2.9	2.9	-2.7	-2.5	2.5	-2.1
Social time	0.3	0.4	0.4	0.5	-0.6	0.7	0.6	-0.6	0.7
Soleus weight	1.0	3.0	3.2	1.7	-1.8	1.8	1.7	-1.8	1.7
Bone: stiffness	17.9	28.2	31.6	5.6	-5.5	5.3	5.3	-5.2	4.9
Tibialis anterior weight	3.0	10.3	11.7	2.9	-3.1	3.3	3.2	-3.2	3.4
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.1	-0.9	1.0	-0.8	-0.9	0.9	-0.8
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.7	0.8	-0.7	0.8	0.8	-0.8	0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.3	0.4	-0.3
Time to tail flick, test, after self-admin	0.8	0.8	1.0	0.8	-0.9	1.0	0.9	-0.9	1.0
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.8	0.9	-0.9	0.9	0.9	-0.9	0.9
Delta time to tail flick, test, before/after SA	0.9	0.8	1.0	0.8	-0.8	0.8	0.9	-0.9	1.0
Tibia length	4.2	11.7	15.2	3.9	-3.7	3.3	3.3	-3.4	2.8
Ambulatory time before self-admin	4.3	4.5	5.0	-2.2	2.2	-2.1	-2.1	2.1	-2.0
Ambulatory time after self-admin	1.8	2.0	2.7	-1.5	1.6	-1.4	-1.4	1.4	-1.2
Bone: tissue strength	2.0	2.0	2.2	1.5	-1.5	1.4	1.4	-1.4	1.3
Total heroin consumption	1.1	1.2	1.7	1.3	-1.2	1.2	1.1	-1.0	0.9
Bone: trabecular number	3.9	6.1	8.0	2.8	-2.7	2.5	2.4	-2.4	2.0
Bone: trabecular spacing	1.2	1.6	2.2	-1.5	1.4	-1.3	-1.2	1.2	-0.9
Bone: trabecular thickness	0.6	0.7	1.3	0.5	-0.7	0.9	0.9	-0.8	1.1
Bone: trabecular tissue density	0.8	1.2	2.0	0.7	-1.0	1.1	1.1	-1.1	1.4
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	0.2	-0.4	-0.3	0.4	-0.4
Number of responses in last shaping day	0.4	0.5	0.7	0.5	-0.6	0.7	0.7	-0.7	0.8