LOC108351525

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative polyA	XR_001838998.3	0.03	0.03	1.0e-02	-0	0.01	0	0	5.5e-01	1.5e-02	2.1e-01	1.8e-01
2	PL	alternative polyA	XR_010053907.1	0.03	0.03	9.2e-03	-0	0.01	0.01	0	4.3e-01	1.2e-02	1.3e-02	1.1e-01
3	PL	isoform ratio	XR_010053907.1	0.07	0.05	5.7e-03	0.02	0.02	0.02	0.02	1.3e-03	4.5e-03	3.0e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	1.1	1.8	2.6	1.6	-1.6	-0.6
Area under the delay curve	0.3	0.3	1.0	0.0	-0.0	1.0
BMI with tail	5.3	18.4	23.1	-4.8	4.8	3.0
BMI without tail	1.8	5.4	7.8	-2.8	2.8	0.8
Body weight	2.1	9.1	11.5	-3.4	3.4	2.1
Weight adjusted by age	3.4	5.2	5.8	-2.4	2.4	2.0
Bone surface	0.3	0.6	0.8	0.9	-0.9	0.6
Bone volume	0.7	1.2	1.8	1.3	-1.3	0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.1	-0.7	0.7	1.0
Number of licking bursts	0.2	0.3	0.5	0.7	-0.7	-0.4
Context. condit. distance diff. score	1.2	1.5	2.3	-1.5	1.5	-0.1
Locomotion velocity, session 1	0.1	0.1	0.4	-0.0	-0.0	0.6
Locomotion distance, session 1	1.7	2.2	3.3	1.8	-1.8	-0.2
Locomotion velocity, session 2	0.5	0.6	0.9	-0.7	0.6	1.0
Locomotion distance, session 2	0.9	1.3	1.9	1.3	-1.4	-0.3
Locomotion velocity, session 3	1.3	1.5	4.0	0.5	-0.4	-2.0
Locomotion distance, session 3	0.2	0.2	0.5	-0.0	0.0	-0.7
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	1.1	-1.1	-0.1
Stereotopy head waving duration, day 3	0.8	0.9	1.2	1.1	-1.1	-0.7
Locomotion velocity, session 7	0.5	0.6	0.8	-0.8	0.9	-0.6
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.4	-0.2
Stereotopy head waving bouts, day 7	1.1	1.2	1.3	1.2	-1.1	-1.0
Stereotopy head waving duration, day 7	1.7	2.1	2.5	1.4	-1.3	-1.6
Locomotion velocity, session 8	0.2	0.3	0.4	-0.6	0.6	-0.2
Locomotion distance, session 8	0.5	0.8	1.0	-1.0	1.0	0.5
Degree of sensitization distance	1.4	1.4	1.9	-1.1	1.1	1.4
Degree of sensitization stereotypy	0.9	1.0	1.7	0.8	-0.8	-1.3
Conditioned locomotion	0.5	0.6	0.9	-0.9	1.0	-0.1
Cocaine response after cond. corrected	0.4	0.4	0.6	-0.8	0.8	0.3
Cocaine response after cond. not corrected	1.0	1.1	1.7	-1.3	1.3	0.3
Cocaine response before conditioning	0.9	1.0	1.5	-1.2	1.2	0.4
Saline control response	2.2	2.9	3.0	-1.7	1.7	1.7
Bone: connectivity density	1.1	1.8	2.3	1.5	-1.5	-0.8
Bone: cortical apparent density	1.6	2.2	2.6	1.6	-1.6	-1.2
Bone: cortical area	2.6	4.0	5.3	-1.9	1.8	2.3
Bone: cortical porosity	0.9	1.0	2.2	-0.6	0.6	1.5
Bone: cortical porosity	1.7	1.8	3.5	-1.0	1.0	1.9
Bone: cortical thickness	0.4	0.6	1.0	-0.7	0.7	1.0
Bone: cortical thickness	0.8	1.0	1.4	-1.2	1.2	0.4
Bone: cortical tissue density	1.5	2.1	2.4	1.5	-1.5	-1.2
Condit. Reinf. active minus inactive responses	4.5	5.0	6.2	-2.5	2.5	1.6
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.4	-1.2	1.2	0.4
Condit. Reinf. active responses	4.5	5.5	6.8	-2.6	2.6	1.7
Condit. Reinf. inactive responses	2.0	2.5	2.8	-1.7	1.7	1.3
Incentive salience index mean	6.0	7.4	8.7	-2.9	3.0	2.2
Condit. Reinf. lever presses	3.7	5.1	5.9	-2.4	2.4	1.9
Condit. Reinf. active minus inactive responses	1.3	1.7	4.0	-0.7	0.7	2.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-0.5	0.5	1.0
Condit. Reinf. active responses	2.6	3.6	6.9	-1.4	1.4	2.6
Condit. Reinf. inactive responses	1.3	1.7	2.6	-1.2	1.1	1.6
Condit. Reinf. lever presses	3.8	5.2	5.9	-2.2	2.2	2.4
Condit. Reinf. lever reinforcers received	2.4	3.4	6.7	-1.3	1.3	2.6
Conditioned reinforcement - actives	0.5	0.9	1.4	-0.9	0.8	1.2
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	0.2	0.2
Conditioned locomotion	1.8	2.3	2.9	-1.7	1.7	1.1
Patch foraging indifference point 0 sec	0.7	1.4	1.8	-1.3	1.3	0.7
Patch foraging indifference point AUC	0.9	1.4	4.1	-0.2	0.1	2.0
Delay disc. indifference point, 0s delay	3.0	3.3	5.3	-1.5	1.5	2.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.8	-0.2	0.2	0.9
Delay disc. indifference point, 2s delay	1.5	1.6	4.3	0.5	-0.6	2.1
Delay disc. indifference point, 24s delay	0.9	1.1	1.5	-1.2	1.2	0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.3	-0.3	0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	-0.4	0.1
Indifference point function ln k	1.4	2.4	3.6	-1.9	1.9	0.1
Indifference point function log k	1.4	2.4	3.6	-1.9	1.9	0.1
Patch foraging total patch changes 0 sec	0.4	0.7	1.1	-1.0	1.0	0.4
Patch foraging total patch changes 12 sec	1.1	1.4	2.3	-0.9	0.9	1.5
Patch foraging total patch changes 18 sec	0.3	0.5	1.0	0.4	-0.4	1.0
Patch foraging total patch changes 24 sec	0.2	0.4	1.0	-0.2	0.2	1.0
Patch foraging total patch changes 6 sec	0.3	0.5	1.2	-0.4	0.4	1.1
Patch foraging time to switch 0 sec	0.8	1.7	2.1	1.4	-1.4	-1.0
Patch foraging water rate 0 sec	0.9	1.8	2.7	-1.6	1.6	0.5
Patch foraging water rate 12 sec	1.9	4.0	5.4	-2.3	2.3	1.2
Patch foraging water rate 18 sec	1.8	2.8	4.2	-2.0	2.1	0.2
Patch foraging water rate 24 sec	0.4	0.6	0.9	-0.9	0.9	-0.4
Patch foraging water rate 6 sec	0.6	0.8	1.2	-1.1	1.1	0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	1.3	1.1	-1.1	-1.1
Distance traveled before self-admin	0.9	1.2	1.6	1.3	-1.3	-0.7
Distance traveled after self-admin	0.6	0.7	1.1	0.7	-0.7	-1.1
Extensor digitorum longus weight	0.6	2.4	3.7	-1.9	1.9	0.2
Bone: elastic displacement	0.3	0.3	0.3	0.6	-0.6	-0.6
Bone: elastic work	0.4	0.5	0.6	-0.8	0.8	0.6
Bone: endosteal estimation	1.1	2.4	2.4	-1.6	1.6	1.5
Bone: endosteal perimeter	4.2	8.9	14.2	-2.5	2.5	3.8
Epididymis fat weight	3.0	10.3	10.7	-3.2	3.1	3.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.1	-0.1	0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.0	0.0
Diff in mean of infusions in LGA sessions	3.0	3.7	3.9	-1.9	1.9	2.0
Delay discount exponential model param	0.2	0.2	0.6	-0.1	0.1	-0.7
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.0	-0.0	0.6
Active lever presses in extinction session 6	1.4	1.4	2.0	-1.4	1.4	0.5
Bone: final force	0.1	0.2	0.5	-0.3	0.3	0.7
Bone: final moment	0.0	0.1	0.2	-0.0	-0.0	0.4
Food consumed during 24 hour testing period	2.7	3.7	5.4	-2.3	2.3	0.7
Glucose	0.1	0.2	0.5	-0.3	0.3	0.7
Heart weight	0.3	0.4	0.6	-0.8	0.8	-0.4
Delay discount hyperbolic model param	0.2	0.3	0.6	-0.3	0.3	-0.8
Intermittent access intake day 1-15 change	0.5	1.0	1.2	-1.1	1.1	0.8
Intermittent access intake escalation	0.5	1.1	1.3	-1.1	1.1	0.9
Intermittent access intake escalation 2	2.4	2.8	3.3	-1.6	1.6	1.8
Intermitt. access day 1 inactive lever presses	0.3	1.1	1.8	-0.9	0.9	1.4
Intermitt. access day 15 inactive lever presses	0.5	1.0	1.5	-1.2	1.2	-0.3
Intermitt. access escalation Index	0.6	0.8	0.9	0.9	-0.9	-0.9
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.2	-0.2	-0.4
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	0.2	0.1
Intermittent access terminal intake (last 3 days)	0.9	1.2	1.3	-1.2	1.1	1.1
Intermittent access total infusions	0.0	0.1	0.1	-0.2	0.1	0.3
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	0.2	0.3
Intermittent access day 15 total locomotion	0.9	1.6	1.7	-1.3	1.3	1.2
Intermittent access total locomotion	0.7	0.8	1.1	-1.1	1.1	0.5
Intermittent access standard deviation	0.0	0.1	0.3	-0.0	0.0	-0.5
Left kidney weight	3.8	17.6	22.1	-4.7	4.7	3.0
Right kidney weight	5.6	25.4	32.8	-5.7	5.7	3.3
Cocaine induced anxiety	0.3	0.5	0.7	-0.8	0.8	-0.2
Post-drug Anxiety	0.9	0.9	1.3	-1.1	1.1	-0.5
Baseline Anxiety	0.2	0.3	0.3	0.5	-0.5	-0.5
Tail length	0.6	2.4	3.1	1.8	-1.8	-1.0
Length with tail	0.0	0.1	0.2	0.1	-0.1	0.4
Length without tail	0.7	2.4	3.8	-1.3	1.3	1.9
Times rat made contact with spout	0.9	1.0	3.1	-0.1	0.2	-1.8
Lifetime Intake	0.0	0.0	0.0	-0.0	0.0	0.2
Liver weight, left	1.0	1.6	2.6	-1.1	1.0	1.6
Liver weight, right	0.1	0.1	0.3	0.0	-0.0	0.5
Locomotor activity	1.0	1.6	2.8	-1.0	1.0	1.7
Locomotor testing distance	0.3	0.5	0.7	0.8	-0.8	-0.5
Locomotor testing rearing	0.9	1.8	5.0	-0.5	0.5	2.2
Locomotion in novel chamber	0.6	0.7	2.1	-0.2	0.2	-1.4
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.2	-0.2	0.4
Fecal boli incidents, locomotor time 1	0.2	0.3	0.4	0.5	-0.5	-0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.3	-0.6	0.6	0.4
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.7	-0.8	0.7	0.8
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.3	0.3	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.8	0.1	-0.1	-0.9
Rest time, locomotor task time 1	1.6	1.9	2.6	1.3	-1.3	-1.6
Distance moved, locomotor task time 1	1.0	1.5	1.7	-1.2	1.2	1.3
Vertical activity count, locomotor time 1	1.5	3.7	4.1	-1.9	1.9	2.0
Time >=10cm from walls, locomotor time 2	1.9	2.8	3.0	-1.7	1.7	1.6
Bouts of movement, locomotor time 2	0.5	0.7	1.0	1.0	-1.0	-0.5
Total resting periods, locomotor time 2	0.4	0.6	0.8	0.9	-0.9	-0.4
Rest time, locomotor task time 2	2.2	2.8	2.8	1.7	-1.7	-1.7
Distance moved, locomotor task time 2	4.5	5.4	6.2	-2.5	2.5	1.9
Vertical activity count, locomotor time 2	4.2	5.8	6.7	-2.6	2.6	2.0
Light reinforcement 1	0.7	1.8	2.7	-1.2	1.2	1.6
Light reinforcement 2	3.8	5.9	7.6	-2.3	2.2	2.8
Bone: marrow area	0.9	2.0	2.0	-1.4	1.4	1.4
Bone: maximum diameter	3.5	6.6	6.9	-2.6	2.6	2.4
Bone: maximum force	0.1	0.2	0.4	-0.4	0.4	0.6
Bone: maximum moment	0.0	0.0	0.1	-0.1	0.1	0.3
Mean time between licks in bursts	1.9	4.6	5.1	2.3	-2.2	-1.9
Mean num. licks in bursts	0.2	0.4	0.5	-0.5	0.6	-0.7
Cd content in liver	0.1	0.1	0.1	0.2	-0.2	0.4
Co content in liver	0.4	0.4	1.2	-0.1	0.1	1.1
Cu content in liver	2.3	2.7	4.5	1.4	-1.3	-2.1
Fe content in liver	0.2	0.2	0.6	0.0	-0.1	0.8
K content in liver	0.3	0.2	0.3	0.6	-0.6	-0.2
Mg content in liver	0.6	0.7	1.0	1.0	-1.0	-0.0
Mn content in liver	0.2	0.2	0.2	0.4	-0.5	0.4
Na content in liver	1.2	1.3	1.9	1.4	-1.4	0.5
Rb content in liver	0.3	0.4	0.8	-0.4	0.4	0.9
Se content in liver	0.1	0.1	0.2	-0.1	0.1	-0.4
Sr content in liver	2.1	1.8	1.9	1.4	-1.4	-1.3
Zn content in liver	2.0	2.2	2.8	1.4	-1.4	-1.7
Bone: minimum diameter	1.6	2.9	3.9	-1.5	1.5	2.0
Time in familiar zone, hab. session 1	0.5	0.5	1.2	0.4	-0.4	-1.1
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.3	-0.3	0.7
Total zone transitions, hab. session 1	1.8	2.6	3.7	1.9	-1.9	-0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.3	-0.3	0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.2	-0.2	0.7
Time in familiar zone, hab. session 2	0.5	0.6	0.8	-0.9	0.9	-0.5
Time in novel zone, hab. session 2	0.9	0.9	1.3	1.1	-1.1	-0.3
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	0.1	-0.3
Total locomotion distance, hab. session 2	0.4	0.5	0.6	-0.8	0.8	0.6
Locomotion velocity, hab. session 2	0.5	0.6	0.7	-0.8	0.8	0.7
Novel to familiar place preference ratio	0.9	1.0	2.0	0.7	-0.7	-1.4
Novelty place preference	0.9	1.0	2.1	0.7	-0.6	-1.4
Time in novel zone, NPP test	1.3	1.4	3.0	0.8	-0.8	-1.7
Total zone transitions, NPP test	0.6	0.9	1.0	1.0	-1.0	-0.8
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.2	0.2	0.5
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.2	0.2	0.6
Intraocular pressure	1.2	1.7	2.6	-1.1	1.1	1.6
Delta distance traveled before/after self-admin	1.2	1.3	1.9	-1.4	1.4	-0.4
Delta ambulatory time before/after self-admin	1.0	1.3	1.8	-1.3	1.3	-0.5
Parametrial fat weight	0.5	1.1	1.8	-0.9	0.9	1.4
Pavlov. Cond. lever latency	2.2	2.8	2.9	1.7	-1.7	-1.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.5	0.5	0.3
Pavlov. Cond. change in total contacts	1.5	1.6	2.2	-1.2	1.1	1.5
Pavlov. Cond. index score	0.5	0.7	0.7	-0.8	0.8	0.8
Pavlov. Cond. latency score	0.9	1.1	1.1	-1.1	1.0	1.0
Pavlov. Cond. lever contacts	2.0	2.3	2.5	-1.6	1.6	1.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.6	-0.6	-0.5
Pavlov. Cond. intertrial magazine entries	2.0	2.4	2.6	-1.6	1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.7	0.7	0.8
Pavlov. Cond. response bias	0.9	1.1	1.4	-1.2	1.2	0.8
Pavlov. Cond. lever latency	1.8	2.5	3.0	1.7	-1.7	-1.1
Pavlov. Cond. magazine entry latency	1.9	2.3	3.0	-1.7	1.7	0.9
Pavlov. Cond. change in total contacts	1.3	2.1	3.2	-1.3	1.2	1.8
Pavlov. Cond. index score	1.9	2.6	3.0	-1.7	1.7	1.3
Pavlov. Cond. latency score	2.6	3.4	4.2	-2.1	2.1	1.3
Pavlov. Cond. lever contacts	2.1	2.8	3.5	-1.9	1.9	1.2
Pavlov. Cond. magazine entry number	2.5	3.1	3.9	1.9	-2.0	-1.3
Pavlov. Cond. intertrial magazine entries	1.0	1.5	1.6	1.3	-1.3	-1.1
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.7	3.2	-1.8	1.8	1.3
Pavlov. Cond. response bias	1.1	1.5	1.6	-1.3	1.3	1.1
Time in closed arm before self-admin	0.5	0.6	1.9	0.1	-0.1	1.4
Time in closed arm after self-admin	1.2	1.3	3.7	-0.4	0.4	1.9
Time in open arm before self-admin	0.4	0.5	1.2	0.3	-0.3	-1.1
Time in open arm after self-admin	0.1	0.1	0.2	-0.2	0.2	-0.4
Bone: periosteal estimation	2.2	4.7	5.6	-2.1	2.1	2.4
Bone: periosteal perimeter	4.5	7.7	10.6	-2.5	2.5	3.3
Bone: post-yield work	0.9	1.4	1.5	1.2	-1.2	-1.1
Progressive ratio test 1 active lever presses	0.5	0.7	1.5	0.5	-0.5	-1.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.4	0.6	-0.6	-1.2
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	-0.2	0.2	0.3
Progressive ratio test 2 active lever presses	0.3	0.3	0.5	-0.7	0.7	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.5	0.5	0.4
Progressive ratio test 2 inactive lever presses	0.6	0.9	1.0	-1.0	1.0	0.9
Incentive Sensitization - Responses	1.5	2.1	2.4	-1.4	1.4	1.6
Incentive Sensitization - Breakpoint	1.5	1.9	2.2	-1.3	1.3	1.5
Sum of active levers in priming session hrs 5-6	0.1	0.0	0.1	0.0	-0.0	0.4
Progressive ratio	0.1	0.1	0.3	-0.1	0.1	-0.5
Food seeking constrained by brief footshock	1.2	1.5	1.8	-1.4	1.3	0.9
Seeking ratio, punishment vs. effort	0.5	0.7	1.5	-0.5	0.5	1.2
Retroperitoneal fat weight	3.1	13.2	14.1	-3.8	3.7	3.4
Reaction time number correct	0.2	0.3	0.4	0.6	-0.6	-0.5
Reaction time mean minus median	0.2	0.5	0.6	-0.8	0.8	0.6
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.6	0.6	0.2
Reaction time num false alarms	0.0	0.0	0.1	0.2	-0.2	-0.0
Reaction time num false alarms AUC	0.0	0.1	0.2	0.1	-0.1	-0.4
Reaction time trials correct on left	0.2	0.3	0.4	0.6	-0.6	-0.5
Reaction time trials on left	0.2	0.4	0.4	0.6	-0.6	-0.5
Reaction time mean	0.5	0.8	1.6	0.6	-0.6	-1.3
Reaction time mean AUC	0.5	0.8	1.4	0.7	-0.7	-1.2
Median of all reaction times	1.2	1.7	3.6	0.9	-0.9	-1.9
Reaction time omissions	0.6	0.9	1.1	0.9	-0.9	-1.1
Reaction time false alarm rate	0.0	0.0	0.0	-0.2	0.1	0.0
Reaction time premature initiation rate	6.3	8.7	9.4	-2.9	2.9	3.1
Reaction time premature initiations	2.6	4.6	4.8	-2.1	2.1	2.2
Std. dev. reaction times	0.1	0.1	0.2	-0.4	0.5	-0.1
Reaction time trials completed	0.2	0.4	0.4	0.6	-0.6	-0.5
Reaction time trials AUC	0.1	0.2	0.2	0.4	-0.4	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.2	-0.2	-0.8
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.3	-0.3	0.6
Latency to leave start box in cocaine runway	0.7	0.7	1.1	-1.1	1.1	-0.0
Latency to leave start box in cocaine runway, F	1.1	1.2	1.4	-1.2	1.2	-0.9
Latency to leave start box in cocaine runway, M	0.7	0.6	1.8	-0.3	0.3	1.3
Std. dev. time between licks in bursts	1.1	1.5	3.2	-0.9	0.8	1.8
Total sessions with >9 infusions	0.1	0.1	0.2	0.2	-0.2	-0.4
Short access day 1 total inactive lever presses	2.3	3.1	4.6	-2.1	2.1	0.3
Short access day 10 total inactive lever presses	3.7	9.0	10.5	-3.2	3.2	2.5
Short access day 1 total infusions	0.1	0.1	0.1	-0.4	0.4	-0.3
Short access day 10 total infusions	0.1	0.2	0.2	-0.5	0.5	0.1
Short access total infusions	0.0	0.0	0.1	-0.3	0.3	0.0
Short access day 1 locomotion	0.1	0.1	0.1	-0.3	0.3	-0.3
Short access day 10 total locomotion	0.2	0.4	0.5	-0.7	0.7	0.4
Short access total locomotion	0.1	0.1	0.1	-0.3	0.3	0.2
One hour access (0.3 mA shock)	0.9	1.0	1.8	-0.8	0.7	1.4
Compulsive drug intake	0.1	0.2	0.2	-0.5	0.5	0.2
One hour access (shock baseline)	0.2	0.4	1.0	-0.2	0.2	1.0
Social response proportion	0.1	0.1	0.3	-0.0	0.0	0.5
Social responses	0.2	0.2	0.5	-0.3	0.3	0.7
Social time	0.3	0.4	1.1	-0.3	0.3	-1.0
Soleus weight	0.7	2.1	3.1	-1.8	1.8	0.5
Bone: stiffness	0.1	0.1	0.2	0.5	-0.5	-0.1
Tibialis anterior weight	0.1	0.2	0.3	-0.5	0.5	-0.1
Time to tail flick, vehicle, before self-admin	2.6	2.7	2.9	-1.7	1.7	1.5
Time to tail flick, vehicle, after self-admin	0.8	1.0	1.2	-1.1	1.1	0.9
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.3	0.3	0.5
Time to tail flick, test, after self-admin	1.2	1.2	1.8	-1.4	1.4	0.0
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.9	0.9	-0.9	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.4	0.4	-0.4
Tibia length	0.8	2.3	3.3	1.8	-1.8	-0.6
Ambulatory time before self-admin	0.7	1.0	1.1	1.0	-1.0	-1.0
Ambulatory time after self-admin	0.3	0.4	1.1	-0.1	0.1	-1.1
Bone: tissue strength	4.1	4.2	4.2	2.0	-2.0	-2.0
Total heroin consumption	0.4	0.5	0.8	-0.6	0.6	0.9
Bone: trabecular number	1.1	1.8	2.4	1.5	-1.5	-0.7
Bone: trabecular spacing	1.2	1.6	2.0	-1.4	1.4	0.8
Bone: trabecular thickness	0.4	0.5	1.4	0.0	-0.1	1.2
Bone: trabecular tissue density	0.9	1.4	2.1	1.4	-1.4	-0.2
Water consumed over 24 hours	0.1	0.2	0.3	-0.5	0.5	0.0
Number of responses in last shaping day	1.2	1.3	1.6	1.3	-1.3	-0.9