LOC108351305

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression LOC108351305 0.15 0.11 1.4e-03 0.13 0.09 0.14 0.14 5.0e-04 4.3e-03 3.0e-04 4.1e-04
2 Brain gene expression LOC108351305 0.34 0.13 0.0e+00 0.42 0.42 0.42 0.42 2.0e-41 2.5e-42 1.0e-41 1.2e-42
3 OFC gene expression LOC108351305 0.17 0.11 4.2e-04 0.15 0.14 0.13 0.13 2.1e-04 4.3e-04 6.7e-04 6.5e-04
4 BLA gene expression LOC108351305 0.25 0.14 9.4e-13 0.22 0.25 0.24 0.24 3.1e-12 1.2e-13 4.7e-13 2.8e-13
5 NAcc gene expression LOC108351305 0.52 0.19 0.0e+00 0.47 0.47 0.47 0.47 2.8e-61 4.2e-60 6.9e-61 2.6e-60
6 PL gene expression LOC108351305 0.2 0.1 0.0e+00 0.24 0.25 0.25 0.25 1.5e-26 2.5e-27 6.0e-27 4.8e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.00.2-0.2-0.10.4-0.00.2-0.2
Area under the delay curve0.10.10.10.2-0.30.3-0.30.1-0.1
BMI with tail2.37.48.42.7-2.92.5-2.82.6-2.8
BMI without tail0.51.01.51.0-1.20.3-1.01.1-1.0
Body weight0.62.43.7-1.91.5-1.41.6-1.61.2
Weight adjusted by age0.30.40.5-0.70.6-0.10.7-0.70.6
Bone surface0.00.10.20.3-0.30.4-0.20.2-0.1
Bone volume0.00.00.10.1-0.20.2-0.10.2-0.1
Breakpoint value in progressive ratio session0.30.30.50.7-0.50.2-0.70.7-0.7
Number of licking bursts0.10.10.30.5-0.30.1-0.30.3-0.0
Context. condit. distance diff. score3.74.55.1-2.12.3-1.82.2-2.22.1
Locomotion velocity, session 10.10.20.2-0.40.4-0.30.4-0.40.4
Locomotion distance, session 10.60.70.90.7-0.80.9-0.90.8-1.0
Locomotion velocity, session 20.00.00.10.2-0.1-0.3-0.0-0.10.1
Locomotion distance, session 20.20.30.50.6-0.70.6-0.60.5-0.5
Locomotion velocity, session 30.10.10.20.2-0.30.4-0.30.3-0.4
Locomotion distance, session 30.00.00.0-0.00.00.00.1-0.10.1
Stereotopy head waving bouts, day 30.10.10.2-0.20.2-0.40.2-0.10.2
Stereotopy head waving duration, day 30.20.20.5-0.40.4-0.70.3-0.30.4
Locomotion velocity, session 70.20.30.50.3-0.40.7-0.50.4-0.6
Locomotion distance, session 70.70.81.01.0-0.91.0-0.90.8-0.9
Stereotopy head waving bouts, day 71.41.62.6-1.61.2-1.01.3-1.21.1
Stereotopy head waving duration, day 70.50.61.2-1.10.8-0.60.8-0.70.6
Locomotion velocity, session 80.91.11.6-1.31.1-0.71.1-1.10.9
Locomotion distance, session 80.30.40.7-0.70.7-0.20.7-0.80.5
Degree of sensitization distance0.20.20.30.5-0.40.5-0.50.5-0.4
Degree of sensitization stereotypy0.30.30.8-0.90.5-0.20.6-0.60.4
Conditioned locomotion1.31.61.7-1.31.2-1.21.3-1.31.2
Cocaine response after cond. corrected0.91.01.50.8-1.00.7-1.11.2-1.2
Cocaine response after cond. not corrected2.32.63.31.4-1.61.4-1.61.7-1.8
Cocaine response before conditioning1.82.23.01.5-1.51.7-1.41.4-1.3
Saline control response0.00.00.2-0.2-0.10.40.10.1-0.2
Bone: connectivity density0.30.40.5-0.70.7-0.10.7-0.70.6
Bone: cortical apparent density6.78.810.5-2.82.9-3.22.9-2.93.0
Bone: cortical area0.30.41.4-0.60.5-1.20.5-0.40.6
Bone: cortical porosity0.30.40.5-0.60.6-0.10.7-0.70.6
Bone: cortical porosity0.10.10.2-0.30.20.40.3-0.20.1
Bone: cortical thickness0.20.30.9-0.70.4-1.00.4-0.30.3
Bone: cortical thickness0.80.91.3-1.10.9-0.91.0-0.80.9
Bone: cortical tissue density6.99.110.8-2.93.0-3.32.9-2.93.1
Condit. Reinf. active minus inactive responses0.60.71.00.7-0.80.6-0.90.9-1.0
Condit. Reinf. active-inactive response ratio2.62.93.11.7-1.71.6-1.71.6-1.8
Condit. Reinf. active responses0.10.20.40.2-0.40.1-0.40.5-0.6
Condit. Reinf. inactive responses1.51.82.7-1.51.4-1.61.3-1.21.1
Incentive salience index mean0.50.71.10.5-0.80.7-0.80.9-1.1
Condit. Reinf. lever presses0.10.20.40.1-0.40.4-0.50.5-0.6
Condit. Reinf. active minus inactive responses1.01.21.3-1.01.1-1.01.2-1.11.1
Condit. Reinf. active-inactive response ratio0.90.91.2-0.71.0-1.11.0-1.01.0
Condit. Reinf. active responses0.10.10.2-0.40.3-0.40.4-0.30.4
Condit. Reinf. inactive responses0.40.50.60.4-0.70.7-0.70.8-0.8
Condit. Reinf. lever presses0.70.91.41.2-0.91.0-0.80.9-0.8
Condit. Reinf. lever reinforcers received0.20.30.3-0.50.5-0.40.6-0.50.5
Conditioned reinforcement - actives2.12.13.0-1.31.5-1.71.4-1.41.5
Conditioned reinforcement - inactives0.50.60.8-0.90.7-0.80.7-0.80.7
Conditioned locomotion0.20.30.40.3-0.50.6-0.50.5-0.7
Patch foraging indifference point 0 sec3.96.37.2-2.72.6-2.52.5-2.42.3
Patch foraging indifference point AUC1.72.02.9-1.51.5-1.71.3-1.21.1
Delay disc. indifference point, 0s delay0.30.30.7-0.90.5-0.40.5-0.50.4
Delay disc. indifference point, 16s delay0.10.10.30.6-0.3-0.2-0.40.3-0.1
Delay disc. indifference point, 2s delay0.40.50.90.6-0.90.6-0.80.7-0.4
Delay disc. indifference point, 24s delay0.30.30.50.4-0.60.7-0.60.5-0.4
Delay disc. indifference point, 4s delay0.30.30.5-0.60.4-0.30.5-0.60.7
Delay disc. indifference point, 8s delay0.00.00.10.2-0.20.3-0.2-0.0-0.1
Indifference point function ln k1.31.82.2-1.41.4-0.81.5-1.51.5
Indifference point function log k1.31.82.2-1.41.4-0.81.5-1.51.5
Patch foraging total patch changes 0 sec4.67.38.5-2.92.8-2.62.8-2.62.5
Patch foraging total patch changes 12 sec3.44.44.9-2.02.0-2.12.1-2.22.1
Patch foraging total patch changes 18 sec1.01.31.8-1.31.1-1.31.1-1.01.0
Patch foraging total patch changes 24 sec0.20.30.5-0.70.5-0.60.5-0.40.4
Patch foraging total patch changes 6 sec1.92.84.7-1.71.7-2.21.5-1.51.3
Patch foraging time to switch 0 sec10.215.719.04.0-4.14.4-3.93.6-3.8
Patch foraging water rate 0 sec17.227.533.1-5.35.3-5.85.1-4.95.1
Patch foraging water rate 12 sec10.916.618.8-3.94.0-4.34.0-4.04.2
Patch foraging water rate 18 sec5.37.28.0-2.82.6-2.52.7-2.72.7
Patch foraging water rate 24 sec4.36.06.4-2.42.4-2.52.5-2.42.5
Patch foraging water rate 6 sec4.97.29.0-2.72.6-3.02.6-2.52.6
Seeking ratio, delayed vs. immediate footshock0.30.40.7-0.80.5-0.40.6-0.80.6
Distance traveled before self-admin0.50.50.80.7-0.80.1-0.80.9-0.6
Distance traveled after self-admin0.60.70.9-0.90.6-1.00.8-0.80.8
Extensor digitorum longus weight7.429.333.4-5.85.6-5.15.5-5.45.1
Bone: elastic displacement0.40.50.7-0.70.6-0.60.7-0.70.9
Bone: elastic work0.00.00.20.10.0-0.20.2-0.20.4
Bone: endosteal estimation0.10.10.40.7-0.40.4-0.20.10.0
Bone: endosteal perimeter0.00.10.10.4-0.2-0.3-0.20.1-0.1
Epididymis fat weight3.78.59.42.8-3.03.1-2.92.7-3.0
Delta time in closed arm before/after self-admin0.10.10.3-0.50.1-0.00.1-0.20.1
Delta time in open arm before/after self-admin0.30.30.6-0.80.5-0.50.5-0.40.4
Diff in mean of infusions in LGA sessions0.10.10.20.3-0.2-0.0-0.40.4-0.5
Delay discount exponential model param0.00.00.1-0.10.2-0.20.2-0.0-0.0
Extinction: sum of active levers before priming0.10.10.30.2-0.20.1-0.40.5-0.4
Active lever presses in extinction session 61.71.72.2-1.21.5-1.31.3-1.21.3
Bone: final force0.20.40.6-0.20.5-0.70.6-0.60.8
Bone: final moment0.30.50.7-0.40.6-0.70.7-0.70.9
Food consumed during 24 hour testing period0.50.61.1-1.00.7-0.60.8-0.80.6
Glucose0.30.51.0-0.60.5-1.00.5-0.50.7
Heart weight0.00.00.00.10.1-0.10.1-0.10.2
Delay discount hyperbolic model param0.10.10.1-0.20.3-0.40.3-0.10.1
Intermittent access intake day 1-15 change1.61.61.81.3-1.31.0-1.31.3-1.3
Intermittent access intake escalation1.61.61.71.3-1.31.1-1.31.3-1.3
Intermittent access intake escalation 20.40.40.50.6-0.60.3-0.70.7-0.7
Intermitt. access day 1 inactive lever presses3.03.23.9-1.62.0-1.71.9-1.81.8
Intermitt. access day 15 inactive lever presses1.11.21.4-0.91.1-1.21.1-1.11.2
Intermitt. access escalation Index0.30.20.3-0.50.4-0.50.5-0.50.6
Intermittent access day 1 total infusions0.10.10.30.3-0.30.3-0.30.3-0.5
Intermittent access day 15 total infusions1.51.72.01.3-1.31.1-1.31.3-1.4
Intermittent access terminal intake (last 3 days)1.92.12.51.5-1.51.2-1.51.4-1.6
Intermittent access total infusions0.40.50.70.7-0.70.5-0.70.6-0.8
Intermittent access day 1 locomotion0.40.40.50.6-0.60.6-0.60.5-0.7
Intermittent access day 15 total locomotion0.00.10.10.3-0.30.1-0.20.2-0.3
Intermittent access total locomotion0.10.20.30.4-0.40.3-0.40.3-0.6
Intermittent access standard deviation3.33.44.61.7-1.81.6-1.91.9-2.1
Left kidney weight1.85.26.1-2.52.3-1.72.5-2.42.1
Right kidney weight1.23.44.1-2.01.9-1.32.0-2.01.8
Cocaine induced anxiety1.72.03.2-1.11.4-1.81.3-1.21.5
Post-drug Anxiety1.21.32.8-0.81.2-1.71.0-0.91.2
Baseline Anxiety1.51.61.91.1-1.31.3-1.31.2-1.4
Tail length4.513.716.3-4.03.7-3.83.7-3.53.4
Length with tail6.523.929.2-5.45.0-4.55.0-4.84.5
Length without tail3.16.77.9-2.82.8-2.02.7-2.82.4
Times rat made contact with spout0.10.10.4-0.30.2-0.60.2-0.20.2
Lifetime Intake0.10.10.20.4-0.40.1-0.40.3-0.4
Liver weight, left2.23.55.2-1.81.8-2.31.8-1.71.8
Liver weight, right0.00.00.1-0.30.1-0.20.1-0.1-0.1
Locomotor activity0.20.30.4-0.60.4-0.30.6-0.70.6
Locomotor testing distance0.30.50.8-0.60.6-0.60.7-0.90.9
Locomotor testing rearing1.72.73.61.9-1.71.5-1.71.5-1.5
Locomotion in novel chamber6.27.68.4-2.42.8-2.82.8-2.72.9
Locomotion in novel chamber post-restriction0.00.00.00.20.0-0.00.10.00.1
Fecal boli incidents, locomotor time 12.62.84.11.2-1.52.0-1.61.8-1.8
Change in fecal boli incidents, locomotor task3.02.83.4-1.51.7-1.81.8-1.71.6
Time >=10cm from walls, locomotor time 10.10.10.40.10.00.3-0.20.3-0.7
Bouts of movement, locomotor time 12.32.54.31.2-1.72.1-1.51.3-1.5
Total resting periods, locomotor time 12.02.23.91.2-1.62.0-1.41.2-1.4
Rest time, locomotor task time 10.00.00.1-0.0-0.30.0-0.20.1-0.0
Distance moved, locomotor task time 10.20.20.70.9-0.20.1-0.40.3-0.2
Vertical activity count, locomotor time 10.30.30.60.10.5-0.70.5-0.60.7
Time >=10cm from walls, locomotor time 20.30.30.5-0.60.7-0.30.6-0.50.4
Bouts of movement, locomotor time 21.81.92.5-1.51.1-1.21.3-1.51.6
Total resting periods, locomotor time 21.41.51.9-1.31.0-1.11.2-1.41.4
Rest time, locomotor task time 20.20.20.6-0.40.3-0.80.3-0.40.4
Distance moved, locomotor task time 20.40.40.91.0-0.60.8-0.60.5-0.5
Vertical activity count, locomotor time 20.10.10.10.10.2-0.00.2-0.30.3
Light reinforcement 10.00.00.0-0.10.1-0.00.1-0.10.1
Light reinforcement 21.92.62.91.7-1.61.4-1.71.6-1.7
Bone: marrow area0.10.10.40.6-0.30.3-0.20.10.1
Bone: maximum diameter0.20.30.40.5-0.6-0.2-0.60.7-0.5
Bone: maximum force0.20.30.5-0.30.4-0.70.5-0.50.7
Bone: maximum moment0.20.30.4-0.40.4-0.60.5-0.50.6
Mean time between licks in bursts0.40.50.70.8-0.70.7-0.70.7-0.7
Mean num. licks in bursts0.20.20.5-0.70.4-0.40.4-0.40.1
Cd content in liver2.22.53.2-1.51.6-1.01.7-1.81.7
Co content in liver1.51.71.9-1.31.4-1.21.3-1.41.3
Cu content in liver1.92.43.21.8-1.61.1-1.61.6-1.5
Fe content in liver0.50.61.11.0-0.90.7-0.80.7-0.6
K content in liver0.10.10.2-0.50.3-0.40.3-0.20.1
Mg content in liver0.20.20.5-0.40.4-0.70.4-0.40.4
Mn content in liver0.50.60.8-0.70.8-0.60.9-0.90.8
Na content in liver0.50.50.70.6-0.70.5-0.80.8-0.8
Rb content in liver1.11.41.6-1.11.1-1.11.2-1.31.3
Se content in liver0.00.00.10.1-0.20.3-0.10.1-0.2
Sr content in liver0.50.40.6-0.50.6-0.60.7-0.70.8
Zn content in liver0.10.10.4-0.40.2-0.60.3-0.30.4
Bone: minimum diameter0.91.72.1-1.21.2-1.51.3-1.31.3
Time in familiar zone, hab. session 10.10.10.40.1-0.00.6-0.10.0-0.1
Time in novel zone, hab. session 10.30.30.50.5-0.70.4-0.60.6-0.5
Total zone transitions, hab. session 10.10.20.60.5-0.40.8-0.20.2-0.2
Total locomotion distance, hab. session 10.50.81.2-0.70.8-0.51.0-1.11.0
Locomotion velocity, hab. session 11.11.51.9-1.11.2-1.11.3-1.41.3
Time in familiar zone, hab. session 20.10.10.40.1-0.20.7-0.30.3-0.5
Time in novel zone, hab. session 20.10.10.20.4-0.40.0-0.30.4-0.2
Total zone transitions, hab. session 20.70.91.10.7-0.91.0-0.91.0-1.1
Total locomotion distance, hab. session 20.30.40.6-0.80.5-0.70.7-0.60.6
Locomotion velocity, hab. session 20.50.60.9-0.90.7-0.90.8-0.70.7
Novel to familiar place preference ratio0.60.70.80.7-0.80.9-0.80.9-0.8
Novelty place preference0.40.40.50.6-0.70.7-0.60.7-0.6
Time in novel zone, NPP test0.20.20.40.4-0.50.6-0.50.5-0.5
Total zone transitions, NPP test0.10.20.5-0.70.40.30.5-0.40.2
Total locomotion distance, NPP test0.30.40.6-0.80.6-0.20.7-0.80.6
Locomotion velocity, NPP test0.30.40.6-0.80.6-0.40.7-0.80.6
Intraocular pressure0.00.10.2-0.1-0.20.5-0.10.2-0.1
Delta distance traveled before/after self-admin0.50.60.9-0.90.6-0.30.8-1.00.7
Delta ambulatory time before/after self-admin1.81.92.5-1.61.3-0.91.5-1.61.4
Parametrial fat weight0.00.10.10.3-0.30.0-0.30.3-0.2
Pavlov. Cond. lever latency0.70.91.3-0.80.9-0.91.0-1.01.1
Pavlov. Cond. magazine entry latency0.50.71.40.7-0.71.2-0.80.7-0.8
Pavlov. Cond. change in total contacts0.30.30.40.4-0.50.6-0.50.6-0.7
Pavlov. Cond. index score1.11.31.90.9-1.11.4-1.11.1-1.3
Pavlov. Cond. latency score0.81.01.30.8-0.91.1-1.01.0-1.1
Pavlov. Cond. lever contacts1.31.61.91.1-1.21.2-1.31.3-1.4
Pavlov. Cond. magazine entry number0.81.01.5-0.70.9-1.20.9-0.91.1
Pavlov. Cond. intertrial magazine entries6.47.79.2-3.02.9-2.92.7-2.62.5
Pavlov. Cond. lever-magazine prob. diff.0.91.11.50.8-1.01.2-1.01.0-1.2
Pavlov. Cond. response bias1.01.21.70.8-1.01.3-1.11.1-1.3
Pavlov. Cond. lever latency1.21.72.3-1.51.3-1.31.2-1.31.1
Pavlov. Cond. magazine entry latency3.64.14.52.0-2.12.1-1.92.1-2.0
Pavlov. Cond. change in total contacts3.65.06.42.5-2.32.1-2.22.2-2.1
Pavlov. Cond. index score3.24.14.72.2-2.02.1-1.92.0-1.9
Pavlov. Cond. latency score3.44.24.82.2-2.02.1-2.02.0-2.0
Pavlov. Cond. lever contacts1.92.63.21.8-1.71.6-1.51.6-1.5
Pavlov. Cond. magazine entry number2.63.23.4-1.81.9-1.81.7-1.81.8
Pavlov. Cond. intertrial magazine entries5.26.87.3-2.72.6-2.72.6-2.52.6
Pavlov. Cond. lever-magazine prob. diff.3.74.85.62.4-2.22.2-2.12.2-2.1
Pavlov. Cond. response bias2.23.03.21.8-1.81.8-1.61.7-1.6
Time in closed arm before self-admin4.55.18.32.9-2.32.1-2.22.1-1.9
Time in closed arm after self-admin1.31.31.81.3-1.31.3-1.10.9-0.8
Time in open arm before self-admin6.87.48.8-2.82.7-3.02.6-2.62.6
Time in open arm after self-admin4.24.66.5-2.52.3-2.22.1-1.91.8
Bone: periosteal estimation0.00.10.30.00.1-0.60.2-0.20.4
Bone: periosteal perimeter0.00.10.30.1-0.2-0.5-0.10.1-0.1
Bone: post-yield work2.02.73.2-1.51.8-1.21.7-1.81.7
Progressive ratio test 1 active lever presses0.00.00.0-0.0-0.1-0.1-0.0-0.1-0.0
Progressive ratio test 1 breakpoint0.00.00.10.1-0.30.0-0.30.0-0.2
Progressive ratio test 1 inactive lever presses3.23.54.2-2.01.8-1.71.8-1.91.9
Progressive ratio test 2 active lever presses0.00.00.10.1-0.0-0.2-0.0-0.10.0
Progressive ratio test 2 breakpoint0.00.00.1-0.10.1-0.30.1-0.20.1
Progressive ratio test 2 inactive lever presses0.80.91.4-0.71.0-1.20.9-0.91.1
Incentive Sensitization - Responses0.00.00.00.1-0.0-0.00.0-0.10.1
Incentive Sensitization - Breakpoint0.00.00.1-0.00.1-0.20.2-0.20.2
Sum of active levers in priming session hrs 5-60.70.71.10.7-0.80.3-1.01.0-1.0
Progressive ratio0.40.51.6-0.40.5-1.20.4-0.50.8
Food seeking constrained by brief footshock0.60.70.9-0.90.7-0.90.7-0.90.9
Seeking ratio, punishment vs. effort0.00.10.2-0.20.10.40.2-0.2-0.0
Retroperitoneal fat weight0.20.71.00.6-0.90.9-0.90.9-1.0
Reaction time number correct3.24.75.6-2.42.3-2.02.2-2.02.1
Reaction time mean minus median0.10.10.60.0-0.30.8-0.20.1-0.3
Reaction time mean minus median AUC0.10.10.5-0.2-0.10.7-0.0-0.1-0.1
Reaction time num false alarms1.11.52.4-1.51.2-1.31.2-1.11.0
Reaction time num false alarms AUC1.52.12.9-1.71.4-1.51.4-1.31.3
Reaction time trials correct on left3.24.75.6-2.42.3-2.02.2-2.02.1
Reaction time trials on left3.34.75.8-2.42.3-2.02.2-2.12.1
Reaction time mean0.70.91.81.0-1.01.3-0.90.7-0.8
Reaction time mean AUC0.30.51.20.6-0.71.1-0.60.4-0.5
Median of all reaction times0.30.40.70.8-0.70.9-0.50.3-0.4
Reaction time omissions1.41.93.3-1.81.3-0.71.5-1.41.4
Reaction time false alarm rate0.10.10.3-0.50.3-0.50.3-0.30.3
Reaction time premature initiation rate0.70.91.6-0.61.0-1.30.9-0.91.0
Reaction time premature initiations2.53.54.3-1.72.0-2.11.8-1.71.8
Std. dev. reaction times0.30.41.10.5-0.71.1-0.60.4-0.5
Reaction time trials completed3.34.75.8-2.42.3-2.02.2-2.12.1
Reaction time trials AUC3.55.05.8-2.42.4-2.12.2-2.12.1
Run reversals in cocaine runway, females1.71.72.61.3-1.21.6-1.21.3-1.1
Run reversals in cocaine runway, males0.20.20.5-0.10.3-0.70.3-0.40.6
Latency to leave start box in cocaine runway0.30.30.50.2-0.60.2-0.70.7-0.5
Latency to leave start box in cocaine runway, F0.50.61.00.4-0.80.5-0.91.0-0.8
Latency to leave start box in cocaine runway, M0.20.20.30.2-0.50.0-0.60.5-0.5
Std. dev. time between licks in bursts0.00.10.2-0.20.00.50.2-0.1-0.1
Total sessions with >9 infusions0.00.00.10.1-0.0-0.3-0.1-0.0-0.0
Short access day 1 total inactive lever presses0.10.10.1-0.30.4-0.20.3-0.30.3
Short access day 10 total inactive lever presses0.91.01.2-1.10.9-0.61.0-1.11.1
Short access day 1 total infusions0.40.51.0-0.50.7-1.00.6-0.60.7
Short access day 10 total infusions0.20.20.30.5-0.50.1-0.50.4-0.5
Short access total infusions0.10.10.20.4-0.4-0.1-0.40.2-0.2
Short access day 1 locomotion0.20.20.30.4-0.50.3-0.50.5-0.5
Short access day 10 total locomotion0.40.50.70.7-0.70.6-0.70.6-0.8
Short access total locomotion0.00.00.00.1-0.2-0.1-0.10.0-0.1
One hour access (0.3 mA shock)0.10.20.5-0.40.4-0.70.3-0.30.2
Compulsive drug intake0.00.00.1-0.30.20.40.10.0-0.0
One hour access (shock baseline)0.00.00.10.3-0.1-0.2-0.20.1-0.2
Social response proportion0.40.40.8-0.00.4-0.90.5-0.70.9
Social responses0.00.00.10.2-0.20.0-0.10.00.0
Social time1.82.43.3-1.41.5-1.31.6-1.61.8
Soleus weight0.20.51.6-1.30.8-0.10.7-0.60.1
Bone: stiffness1.42.22.8-1.31.5-1.71.5-1.51.5
Tibialis anterior weight0.41.31.7-1.31.2-1.21.1-1.20.9
Time to tail flick, vehicle, before self-admin0.60.71.0-1.00.9-0.70.8-0.80.6
Time to tail flick, vehicle, after self-admin0.10.10.1-0.40.30.40.2-0.2-0.1
Time to tail flick, test, before self-admin0.10.10.1-0.3-0.0-0.40.1-0.20.2
Time to tail flick, test, after self-admin1.71.82.3-1.21.5-1.21.4-1.41.2
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.10.00.30.1-0.0-0.1
Delta time to tail flick, test, before/after SA1.61.42.0-1.31.4-0.91.3-1.21.0
Tibia length0.10.20.4-0.40.4-0.70.4-0.30.5
Ambulatory time before self-admin0.91.01.41.0-1.00.4-1.11.2-0.9
Ambulatory time after self-admin0.00.00.1-0.2-0.2-0.1-0.10.1-0.0
Bone: tissue strength0.00.00.10.2-0.30.1-0.20.2-0.0
Total heroin consumption0.50.61.2-1.10.8-1.10.5-0.40.3
Bone: trabecular number0.20.30.5-0.70.6-0.20.6-0.50.5
Bone: trabecular spacing0.10.10.10.3-0.30.1-0.30.3-0.4
Bone: trabecular thickness0.00.00.1-0.30.2-0.20.2-0.10.2
Bone: trabecular tissue density0.00.00.10.1-0.1-0.3-0.20.1-0.0
Water consumed over 24 hours2.83.44.7-1.71.7-2.21.8-1.81.9
Number of responses in last shaping day0.40.40.60.8-0.70.5-0.70.5-0.6