Hub : Genes

LOC108350745

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC108350745	0.06	0.04	4.0e-05	0.05	0.05	0.04	0.05	1.7e-05	9.5e-06	1.8e-04	3.4e-05
2	NAcc	gene expression	LOC108350745	0.03	0.02	1.7e-04	0.03	0.03	0.03	0.03	5.3e-04	1.3e-04	1.4e-04	2.7e-04
3	PL	gene expression	LOC108350745	0.04	0.02	4.7e-05	0.02	0.03	0.02	0.02	1.6e-03	7.3e-04	1.3e-03	2.7e-03
4	IL	gene expression	LOC108350745	0.4	0.18	9.5e-04	0.16	0.13	0.11	0.11	1.3e-04	5.6e-04	1.1e-03	1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.0	3.4	8.7	-1.1	-1.2	-1.5	3.0
Area under the delay curve	0.0	0.0	0.2	-0.1	0.4	0.1	0.1
BMI with tail	0.8	2.5	3.4	-1.6	-1.9	-1.7	1.1
BMI without tail	0.1	0.1	0.2	-0.0	0.0	-0.5	0.5
Body weight	0.8	3.5	4.0	-1.7	-1.9	-2.0	1.9
Weight adjusted by age	0.0	0.0	0.1	-0.0	0.3	0.2	-0.1
Bone surface	0.6	1.0	3.0	-0.4	-0.5	-0.7	1.7
Bone volume	1.5	2.5	6.0	-1.0	-1.1	-1.3	2.5
Breakpoint value in progressive ratio session	8.3	9.1	10.3	-3.0	-2.7	-3.1	3.2
Number of licking bursts	0.5	0.6	1.1	0.7	0.8	0.1	1.1
Context. condit. distance diff. score	2.9	3.4	5.2	-2.1	-2.3	-2.1	0.3
Locomotion velocity, session 1	0.1	0.1	0.2	0.1	0.3	0.4	-0.1
Locomotion distance, session 1	0.4	0.5	0.7	0.8	0.9	0.7	-0.1
Locomotion velocity, session 2	0.9	1.0	1.6	0.8	1.3	1.2	-0.6
Locomotion distance, session 2	0.9	1.3	2.0	1.3	1.4	1.1	-0.2
Locomotion velocity, session 3	0.5	0.6	0.7	0.8	0.8	0.8	-0.6
Locomotion distance, session 3	0.2	0.2	0.3	0.6	0.5	0.4	-0.3
Stereotopy head waving bouts, day 3	1.8	2.1	3.5	1.0	1.9	1.5	-1.3
Stereotopy head waving duration, day 3	2.0	2.4	4.0	0.8	1.5	1.6	-2.0
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	-0.1	0.2	-0.3
Locomotion distance, session 7	1.1	1.3	2.9	-0.9	-1.7	-1.2	0.5
Stereotopy head waving bouts, day 7	1.7	1.9	3.0	1.0	1.7	1.5	-1.3
Stereotopy head waving duration, day 7	2.1	2.5	3.9	1.0	2.0	1.7	-1.6
Locomotion velocity, session 8	0.2	0.3	0.9	-0.2	-0.0	-0.4	1.0
Locomotion distance, session 8	0.9	1.3	1.9	-1.1	-1.3	-1.4	0.6
Degree of sensitization distance	1.2	1.2	2.9	-0.9	-1.7	-1.0	0.0
Degree of sensitization stereotypy	0.4	0.4	1.0	0.3	1.0	0.6	-0.5
Conditioned locomotion	1.4	1.7	4.2	-0.3	-0.9	-1.3	2.0
Cocaine response after cond. corrected	4.8	5.4	7.3	2.7	2.1	2.3	-2.1
Cocaine response after cond. not corrected	8.8	9.7	12.1	3.5	2.7	3.2	-3.0
Cocaine response before conditioning	1.1	1.4	2.2	0.9	0.9	1.3	-1.5
Saline control response	1.8	2.3	4.2	2.1	1.2	1.5	-1.1
Bone: connectivity density	1.1	1.7	3.7	-0.9	-0.9	-1.1	1.9
Bone: cortical apparent density	0.1	0.1	0.2	-0.0	0.3	0.3	-0.4
Bone: cortical area	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.2
Bone: cortical porosity	0.1	0.2	0.2	-0.4	0.3	0.4	-0.5
Bone: cortical porosity	0.1	0.1	0.4	-0.7	0.1	0.1	-0.2
Bone: cortical thickness	0.1	0.1	0.3	-0.2	0.2	0.3	-0.5
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.3	0.4	0.4
Bone: cortical tissue density	0.1	0.1	0.1	-0.0	0.3	0.3	-0.4
Condit. Reinf. active minus inactive responses	3.0	3.4	4.8	2.2	1.2	2.0	-1.8
Condit. Reinf. active-inactive response ratio	5.2	5.6	7.8	2.8	1.9	2.6	-2.2
Condit. Reinf. active responses	0.6	0.7	1.0	1.0	0.3	1.0	-0.9
Condit. Reinf. inactive responses	1.4	1.7	2.0	-1.3	-1.1	-1.4	1.3
Incentive salience index mean	3.3	3.9	4.8	2.2	1.5	2.2	-2.0
Condit. Reinf. lever presses	1.9	2.6	3.0	1.6	1.5	1.7	-1.6
Condit. Reinf. active minus inactive responses	1.1	1.3	2.0	1.0	0.8	1.3	-1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	0.3	0.1	0.7	-1.0
Condit. Reinf. active responses	0.8	1.1	1.4	1.1	0.7	1.2	-1.1
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.9	0.4	0.3	0.1
Condit. Reinf. lever presses	0.5	0.6	1.4	1.2	0.6	0.7	-0.5
Condit. Reinf. lever reinforcers received	1.3	1.9	2.2	1.5	1.0	1.5	-1.4
Conditioned reinforcement - actives	2.3	2.3	4.4	-1.8	-2.1	-1.3	0.2
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.4	-0.6	-0.1	-0.3
Conditioned locomotion	1.0	1.2	3.0	-1.1	-1.7	-0.8	0.2
Patch foraging indifference point 0 sec	0.3	0.4	1.2	-0.4	-1.1	-0.6	0.3
Patch foraging indifference point AUC	3.4	3.9	5.2	2.3	1.9	2.0	-1.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.6	-0.4	-0.3	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.3	-0.0	0.2	-0.5
Delay disc. indifference point, 2s delay	1.2	1.4	2.0	-1.4	-0.9	-1.2	1.0
Delay disc. indifference point, 24s delay	1.0	1.0	1.8	1.0	1.4	1.0	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.1	0.4	0.0	0.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	0.3	0.9	0.5	-0.1
Indifference point function ln k	2.9	4.0	5.1	-2.3	-2.0	-2.1	1.6
Indifference point function log k	2.9	4.0	5.1	-2.3	-2.0	-2.1	1.6
Patch foraging total patch changes 0 sec	0.4	0.6	1.5	-0.6	-1.2	-0.6	0.2
Patch foraging total patch changes 12 sec	1.0	1.3	2.0	1.4	0.4	1.1	-1.4
Patch foraging total patch changes 18 sec	1.5	1.9	3.2	1.8	0.9	1.4	-1.4
Patch foraging total patch changes 24 sec	0.3	0.4	0.9	0.5	0.0	0.5	-0.9
Patch foraging total patch changes 6 sec	0.6	0.9	1.9	-0.7	-1.4	-0.9	0.5
Patch foraging time to switch 0 sec	1.3	2.0	3.0	-1.5	-0.9	-1.4	1.7
Patch foraging water rate 0 sec	0.7	1.1	2.6	0.6	0.2	1.1	-1.6
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.0	-0.4	-0.2	0.0
Patch foraging water rate 18 sec	0.3	0.4	0.9	-0.9	-0.7	-0.3	0.0
Patch foraging water rate 24 sec	0.6	0.8	2.1	0.7	-0.3	0.8	-1.5
Patch foraging water rate 6 sec	0.3	0.4	1.1	0.4	-0.0	0.5	-1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.9	-0.7	-0.9	-0.8	0.2
Distance traveled before self-admin	1.2	1.3	2.1	1.2	1.4	1.2	-0.6
Distance traveled after self-admin	1.4	1.6	2.3	1.1	0.8	1.5	-1.5
Extensor digitorum longus weight	5.9	23.2	27.7	-5.3	-4.7	-5.2	4.0
Bone: elastic displacement	0.6	0.7	2.4	0.1	-0.1	-0.6	1.5
Bone: elastic work	1.0	1.3	3.4	-0.5	-0.6	-1.1	1.8
Bone: endosteal estimation	0.4	0.9	1.7	-0.7	-0.8	-0.9	1.3
Bone: endosteal perimeter	0.1	0.3	0.5	0.7	0.1	-0.1	0.7
Epididymis fat weight	0.1	0.3	0.8	-0.1	-0.2	-0.5	0.9
Delta time in closed arm before/after self-admin	0.7	0.6	1.7	-1.3	-0.7	-0.6	-0.1
Delta time in open arm before/after self-admin	0.4	0.4	0.8	0.7	0.9	0.4	0.5
Diff in mean of infusions in LGA sessions	0.9	1.0	2.3	-0.1	-0.9	-0.9	1.5
Delay discount exponential model param	0.1	0.1	0.2	0.1	-0.5	-0.1	-0.1
Extinction: sum of active levers before priming	0.4	0.4	0.7	-0.8	-0.6	-0.7	0.3
Active lever presses in extinction session 6	5.2	5.0	7.4	-2.7	-2.3	-2.3	1.4
Bone: final force	0.5	0.8	1.6	-1.3	-1.0	-0.7	0.1
Bone: final moment	0.7	1.1	1.9	-1.4	-1.3	-0.9	0.3
Food consumed during 24 hour testing period	0.2	0.3	0.8	0.9	0.4	0.5	-0.0
Glucose	2.4	3.5	4.7	-1.2	-2.2	-2.0	2.0
Heart weight	0.2	0.3	0.4	-0.5	-0.5	-0.6	0.6
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	-0.3	0.1	-0.2
Intermittent access intake day 1-15 change	2.1	2.1	3.3	-1.7	-1.8	-1.4	0.2
Intermittent access intake escalation	1.4	1.3	2.2	-1.5	-1.4	-1.0	-0.2
Intermittent access intake escalation 2	2.2	2.1	4.0	-2.0	-1.4	-1.5	0.5
Intermitt. access day 1 inactive lever presses	1.5	1.6	1.9	1.3	1.2	1.3	-1.4
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.9	1.0	0.7	0.9	-0.7
Intermitt. access escalation Index	0.6	0.5	1.6	0.4	0.6	-0.2	1.3
Intermittent access day 1 total infusions	0.8	0.9	1.9	-0.9	-1.4	-0.9	0.4
Intermittent access day 15 total infusions	3.3	3.8	6.8	-2.2	-2.6	-1.8	0.5
Intermittent access terminal intake (last 3 days)	4.5	5.0	8.5	-2.5	-2.9	-2.2	0.8
Intermittent access total infusions	2.4	2.6	5.1	-1.5	-2.3	-1.6	0.8
Intermittent access day 1 locomotion	1.7	1.8	3.0	-1.4	-1.7	-1.3	0.8
Intermittent access day 15 total locomotion	3.1	3.3	5.6	-2.2	-2.4	-1.6	0.3
Intermittent access total locomotion	2.7	3.0	6.3	-1.9	-2.5	-1.5	0.3
Intermittent access standard deviation	0.6	0.7	1.3	-1.2	-1.0	-0.4	-0.4
Left kidney weight	2.3	6.6	7.7	2.7	2.8	2.7	-2.0
Right kidney weight	2.2	6.1	8.5	2.7	2.9	2.6	-1.3
Cocaine induced anxiety	0.4	0.5	0.8	0.9	0.6	0.8	-0.3
Post-drug Anxiety	3.4	3.8	4.4	1.9	2.0	2.1	-1.7
Baseline Anxiety	1.1	1.2	1.6	0.9	1.3	1.0	-1.2
Tail length	0.2	0.6	1.0	1.0	1.0	0.4	0.3
Length with tail	0.1	0.3	1.2	0.1	0.1	-0.3	1.1
Length without tail	0.0	0.0	0.1	0.1	-0.1	0.3	0.0
Times rat made contact with spout	0.1	0.1	0.2	0.4	0.3	0.1	-0.1
Lifetime Intake	2.2	2.4	4.6	-1.5	-2.1	-1.5	0.8
Liver weight, left	0.2	0.3	0.9	1.0	0.3	0.4	0.1
Liver weight, right	0.9	1.5	1.9	1.3	1.4	1.3	-0.8
Locomotor activity	0.6	1.0	2.4	1.6	0.9	0.8	-0.1
Locomotor testing distance	1.3	2.2	3.5	1.9	0.9	1.4	-1.6
Locomotor testing rearing	1.9	2.9	4.9	2.2	1.5	1.6	-1.4
Locomotion in novel chamber	0.2	0.2	0.5	0.7	0.5	0.4	-0.0
Locomotion in novel chamber post-restriction	1.0	1.2	1.5	0.9	1.2	1.2	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.7	0.9	0.6	0.3	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.0	0.1	0.1
Time >=10cm from walls, locomotor time 1	4.7	4.8	6.4	2.3	2.5	2.3	-1.5
Bouts of movement, locomotor time 1	0.7	0.8	1.1	-0.8	-1.0	-0.9	0.8
Total resting periods, locomotor time 1	1.4	1.6	2.1	-1.2	-1.5	-1.3	1.0
Rest time, locomotor task time 1	6.6	7.3	8.8	-2.6	-2.6	-3.0	2.7
Distance moved, locomotor task time 1	5.2	5.6	7.3	2.0	2.1	2.6	-2.7
Vertical activity count, locomotor time 1	1.8	1.9	2.6	1.1	1.4	1.6	-1.3
Time >=10cm from walls, locomotor time 2	2.0	2.1	3.0	1.7	1.7	1.4	-0.5
Bouts of movement, locomotor time 2	1.1	1.2	1.3	1.1	1.0	1.1	-1.1
Total resting periods, locomotor time 2	1.4	1.4	1.6	1.2	1.2	1.2	-1.2
Rest time, locomotor task time 2	0.7	0.8	1.0	-1.0	-0.5	-1.0	0.9
Distance moved, locomotor task time 2	0.9	1.0	1.6	0.8	0.7	1.1	-1.3
Vertical activity count, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.1
Light reinforcement 1	0.2	0.4	0.5	0.6	0.5	0.6	-0.7
Light reinforcement 2	0.6	0.8	2.3	-0.9	-0.2	-0.6	1.5
Bone: marrow area	0.4	0.8	1.6	-0.6	-0.7	-0.9	1.2
Bone: maximum diameter	0.2	0.4	0.7	0.8	0.8	0.4	0.6
Bone: maximum force	1.4	2.4	4.0	-2.0	-1.6	-1.5	0.9
Bone: maximum moment	1.6	2.7	4.1	-2.0	-1.7	-1.6	1.1
Mean time between licks in bursts	1.1	1.5	2.5	-1.0	-0.8	-1.3	1.6
Mean num. licks in bursts	0.7	0.8	2.9	-0.1	-0.3	0.5	-1.7
Cd content in liver	1.2	1.3	2.5	-1.1	-1.6	-1.2	0.1
Co content in liver	3.0	3.5	4.8	-1.7	-1.8	-2.2	1.7
Cu content in liver	1.3	1.6	2.8	-1.7	-1.2	-1.3	0.7
Fe content in liver	0.5	0.6	0.9	-0.9	-1.0	-0.6	0.4
K content in liver	1.4	1.4	3.4	0.5	1.8	1.1	-0.7
Mg content in liver	0.8	0.9	1.4	0.3	1.2	1.0	-1.0
Mn content in liver	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.2
Na content in liver	1.3	1.3	2.1	0.9	1.4	1.3	-0.8
Rb content in liver	0.1	0.1	0.2	-0.1	-0.0	0.3	-0.5
Se content in liver	0.9	1.1	2.7	-1.6	-1.1	-0.8	-0.1
Sr content in liver	0.4	0.3	0.6	0.8	0.7	0.4	0.2
Zn content in liver	0.2	0.2	0.5	0.4	0.4	0.4	-0.7
Bone: minimum diameter	0.8	1.4	1.9	-1.4	-1.4	-1.3	0.7
Time in familiar zone, hab. session 1	0.4	0.4	0.9	0.6	-0.2	0.4	-1.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	0.4	0.2	0.1
Total zone transitions, hab. session 1	1.2	1.7	4.0	2.0	1.1	1.1	-0.6
Total locomotion distance, hab. session 1	0.2	0.3	0.9	0.9	0.5	0.4	-0.3
Locomotion velocity, hab. session 1	0.4	0.5	1.1	1.0	0.8	0.5	-0.2
Time in familiar zone, hab. session 2	0.0	0.1	0.2	-0.1	-0.1	-0.2	0.4
Time in novel zone, hab. session 2	0.5	0.5	1.6	0.2	0.1	0.6	-1.3
Total zone transitions, hab. session 2	0.8	1.0	1.8	1.3	1.2	0.9	-0.2
Total locomotion distance, hab. session 2	1.0	1.3	2.0	1.4	1.4	1.1	-0.4
Locomotion velocity, hab. session 2	0.9	1.2	2.0	1.3	1.4	1.0	-0.3
Novel to familiar place preference ratio	0.0	0.0	0.1	0.1	0.2	0.1	-0.2
Novelty place preference	0.1	0.1	0.2	-0.1	0.2	0.1	-0.5
Time in novel zone, NPP test	0.1	0.1	0.3	-0.1	-0.1	0.0	-0.6
Total zone transitions, NPP test	0.6	0.9	1.6	0.8	0.8	0.9	-1.3
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.0	0.5	0.1	-0.2
Intraocular pressure	0.1	0.2	0.3	0.4	-0.4	-0.2	0.6
Delta distance traveled before/after self-admin	0.3	0.4	1.3	-0.2	-1.1	-0.1	-0.4
Delta ambulatory time before/after self-admin	0.4	0.4	1.4	-0.2	-1.2	-0.2	-0.3
Parametrial fat weight	0.3	0.6	1.4	-0.2	-1.2	-0.7	0.7
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.6	0.1	-0.3	0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	2.1	1.3	0.6	1.0	-1.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	0.2	0.4	-0.3
Pavlov. Cond. index score	0.4	0.5	0.9	0.9	0.1	0.5	-0.9
Pavlov. Cond. latency score	0.6	0.7	1.3	1.1	0.2	0.7	-1.2
Pavlov. Cond. lever contacts	0.3	0.3	0.6	0.6	-0.2	0.4	-0.8
Pavlov. Cond. magazine entry number	0.8	1.0	1.7	-1.1	-0.6	-0.9	1.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	-0.9	-0.9	-0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.8	0.1	0.5	-0.8
Pavlov. Cond. response bias	0.6	0.7	1.2	1.0	0.4	0.8	-1.1
Pavlov. Cond. lever latency	0.3	0.3	1.1	-1.1	-0.0	-0.4	0.3
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	1.1	0.7	0.8	-0.8
Pavlov. Cond. change in total contacts	1.7	2.4	3.4	1.9	1.0	1.5	-1.7
Pavlov. Cond. index score	0.8	1.1	2.0	1.4	0.4	1.0	-1.1
Pavlov. Cond. latency score	0.8	1.0	1.7	1.3	0.5	1.0	-1.1
Pavlov. Cond. lever contacts	0.3	0.4	1.1	1.1	-0.0	0.4	-0.5
Pavlov. Cond. magazine entry number	1.6	2.0	3.2	-1.4	-0.8	-1.4	1.8
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.6	0.2	-0.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.9	1.4	0.4	1.0	-1.2
Pavlov. Cond. response bias	0.2	0.3	0.8	0.9	-0.1	0.3	-0.5
Time in closed arm before self-admin	0.0	0.0	0.1	0.1	0.3	0.2	-0.0
Time in closed arm after self-admin	0.4	0.4	1.1	-1.0	-0.5	-0.5	-0.1
Time in open arm before self-admin	0.6	0.6	1.1	-0.7	-1.1	-0.9	0.5
Time in open arm after self-admin	0.4	0.5	1.4	0.2	-0.1	-0.6	1.2
Bone: periosteal estimation	0.3	0.5	1.2	-0.5	-0.5	-0.7	1.1
Bone: periosteal perimeter	0.3	0.5	1.3	1.1	0.7	0.7	-0.1
Bone: post-yield work	0.1	0.1	0.2	-0.3	-0.4	-0.5	0.1
Progressive ratio test 1 active lever presses	0.3	0.3	1.1	-0.2	-1.1	-0.4	0.2
Progressive ratio test 1 breakpoint	0.6	0.6	1.7	-0.5	-1.3	-0.6	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.2	-0.1
Progressive ratio test 2 active lever presses	1.6	1.7	3.2	-1.4	-1.8	-1.3	0.6
Progressive ratio test 2 breakpoint	1.4	1.6	2.8	-1.3	-1.7	-1.2	0.6
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	-0.6	-0.7	-0.3	-0.2
Incentive Sensitization - Responses	0.9	0.9	1.8	-1.0	-1.3	-0.9	0.4
Incentive Sensitization - Breakpoint	1.1	1.1	2.0	-1.0	-1.4	-1.1	0.5
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.4	-1.0	-1.6	-0.9	0.6
Progressive ratio	0.8	0.9	1.7	-0.6	-0.5	-1.2	1.3
Food seeking constrained by brief footshock	5.7	7.0	7.8	-2.3	-2.7	-2.8	2.8
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.7	-0.8	-0.2	-0.1
Retroperitoneal fat weight	0.1	0.2	0.7	-0.3	0.3	0.1	0.8
Reaction time number correct	1.0	1.5	1.9	-1.4	-1.2	-1.2	0.9
Reaction time mean minus median	0.6	0.8	1.9	0.5	0.6	0.9	-1.4
Reaction time mean minus median AUC	0.5	0.7	2.0	0.2	0.3	0.8	-1.4
Reaction time num false alarms	0.3	0.4	0.7	-0.8	-0.6	-0.7	-0.1
Reaction time num false alarms AUC	0.1	0.2	0.2	-0.5	-0.5	-0.5	-0.2
Reaction time trials correct on left	1.0	1.5	1.9	-1.4	-1.2	-1.2	0.9
Reaction time trials on left	0.9	1.2	1.7	-1.3	-1.1	-1.1	0.9
Reaction time mean	1.4	2.0	3.0	1.1	1.1	1.6	-1.7
Reaction time mean AUC	1.0	1.4	2.3	0.8	0.9	1.3	-1.5
Median of all reaction times	1.0	1.4	2.0	1.0	0.9	1.4	-1.4
Reaction time omissions	2.0	2.7	3.2	1.5	1.5	1.8	-1.7
Reaction time false alarm rate	0.3	0.4	1.0	0.5	0.4	0.5	-1.0
Reaction time premature initiation rate	2.1	2.7	4.0	1.5	1.4	1.7	-2.0
Reaction time premature initiations	0.9	1.3	1.9	1.0	1.0	1.2	-1.4
Std. dev. reaction times	2.2	3.1	5.7	1.2	1.3	1.9	-2.4
Reaction time trials completed	0.9	1.2	1.7	-1.3	-1.1	-1.1	0.9
Reaction time trials AUC	0.9	1.3	1.9	-1.4	-1.2	-1.1	0.8
Run reversals in cocaine runway, females	1.8	1.7	2.7	1.7	1.6	1.3	-0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.0	0.6	0.5	-0.3
Latency to leave start box in cocaine runway	4.2	4.6	5.3	2.2	2.2	2.3	-1.8
Latency to leave start box in cocaine runway, F	3.3	3.7	4.3	1.9	1.6	2.0	-2.1
Latency to leave start box in cocaine runway, M	0.9	0.9	1.6	1.0	1.3	0.7	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.1	0.1	0.1	-0.6
Total sessions with >9 infusions	0.1	0.1	0.3	0.5	-0.2	0.3	0.1
Short access day 1 total inactive lever presses	0.5	0.6	1.0	1.0	0.7	0.8	-0.5
Short access day 10 total inactive lever presses	1.1	1.3	1.6	0.9	1.3	1.0	-1.2
Short access day 1 total infusions	0.5	0.5	1.0	-0.6	-1.0	-0.6	0.5
Short access day 10 total infusions	1.3	1.4	2.7	-1.3	-1.6	-1.0	0.4
Short access total infusions	0.7	0.7	1.7	-0.8	-1.3	-0.7	0.5
Short access day 1 locomotion	4.4	4.7	7.0	-2.3	-2.6	-2.1	1.4
Short access day 10 total locomotion	0.1	0.1	0.5	-0.1	-0.0	0.2	-0.7
Short access total locomotion	0.2	0.2	0.5	-0.6	-0.7	-0.2	-0.1
One hour access (0.3 mA shock)	2.4	2.7	4.8	-2.1	-2.2	-1.3	0.2
Compulsive drug intake	2.8	2.8	4.6	1.2	1.3	1.9	-2.1
One hour access (shock baseline)	6.2	7.2	10.0	-2.8	-3.2	-2.8	1.8
Social response proportion	2.8	3.0	5.1	2.3	1.9	1.7	-0.6
Social responses	2.9	3.8	4.0	2.0	1.9	2.0	-1.9
Social time	0.8	1.1	1.2	1.0	1.1	1.1	-1.0
Soleus weight	1.0	2.9	3.8	-1.8	-1.9	-1.7	1.4
Bone: stiffness	1.4	2.3	3.6	-1.9	-1.4	-1.4	1.2
Tibialis anterior weight	0.8	2.9	5.4	-1.3	-1.2	-1.7	2.3
Time to tail flick, vehicle, before self-admin	1.8	1.9	3.1	1.4	1.8	1.5	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.0	-0.1	-0.2	0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.2
Time to tail flick, test, after self-admin	0.2	0.3	0.7	0.2	0.9	0.4	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.1	-0.2	0.0	-0.5
Delta time to tail flick, test, before/after SA	0.7	0.6	1.5	0.7	1.2	0.7	0.1
Tibia length	0.4	1.0	1.3	1.0	0.8	1.1	-1.2
Ambulatory time before self-admin	0.8	0.9	1.4	0.8	1.2	0.9	-0.7
Ambulatory time after self-admin	0.4	0.4	1.0	0.2	0.1	0.7	-1.0
Bone: tissue strength	0.2	0.2	0.7	-0.0	0.1	-0.3	0.8
Total heroin consumption	1.1	1.2	2.0	-1.2	-0.8	-1.0	1.4
Bone: trabecular number	0.7	1.1	3.6	-0.3	-0.4	-0.7	1.9
Bone: trabecular spacing	0.1	0.1	0.4	0.1	0.0	0.2	-0.6
Bone: trabecular thickness	2.2	2.6	6.4	-0.8	-1.3	-1.4	2.5
Bone: trabecular tissue density	1.4	1.9	2.3	1.4	1.3	1.5	-1.2
Water consumed over 24 hours	0.1	0.1	0.4	-0.3	0.0	-0.2	0.6
Number of responses in last shaping day	6.6	6.9	10.4	-2.9	-3.2	-2.7	1.3