Hub : Genes

LOC108350028

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC108350028 0.32 0.18 0.0e+00 0.23 0.22 0.23 0.23 2.4e-25 4.8e-24 4.0e-25 8.2e-25
2 NAcc intron excision ratio chr7_170595_192107 0.03 0.03 2.1e-03 0.02 0.02 0.02 0.01 3.6e-03 7.7e-04 4.1e-03 6.0e-03
3 BLA gene expression LOC108350028 0.1 0.08 6.7e-03 0.02 0.01 0.01 0.02 2.2e-02 4.8e-02 1.4e-01 3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.84.76.70.8-2.62.6
Area under the delay curve0.10.10.20.2-0.40.5
BMI with tail3.511.429.7-5.51.9-0.8
BMI without tail0.81.72.7-1.61.2-1.1
Body weight0.41.74.1-2.00.9-0.5
Weight adjusted by age0.30.40.6-0.00.7-0.8
Bone surface6.110.714.81.6-3.83.8
Bone volume6.210.614.81.6-3.83.8
Breakpoint value in progressive ratio session0.50.51.61.3-0.1-0.2
Number of licking bursts3.23.76.0-2.51.8-1.4
Context. condit. distance diff. score0.10.20.2-0.50.4-0.3
Locomotion velocity, session 11.51.62.30.8-1.31.5
Locomotion distance, session 11.92.43.40.8-1.81.8
Locomotion velocity, session 23.94.65.12.0-2.32.1
Locomotion distance, session 23.95.56.32.2-2.52.2
Locomotion velocity, session 32.02.46.32.5-0.80.3
Locomotion distance, session 30.00.00.10.20.1-0.0
Stereotopy head waving bouts, day 32.73.26.42.5-1.50.9
Stereotopy head waving duration, day 31.72.04.02.0-1.20.7
Locomotion velocity, session 70.20.30.40.1-0.70.6
Locomotion distance, session 70.60.80.9-1.00.9-0.9
Stereotopy head waving bouts, day 71.82.02.41.3-1.51.4
Stereotopy head waving duration, day 72.22.73.01.6-1.71.6
Locomotion velocity, session 83.64.35.12.0-2.32.0
Locomotion distance, session 80.40.60.70.8-0.80.7
Degree of sensitization distance0.40.41.0-1.00.2-0.2
Degree of sensitization stereotypy0.50.50.90.2-0.90.9
Conditioned locomotion2.32.73.2-1.51.8-1.6
Cocaine response after cond. corrected3.13.54.1-1.82.0-1.7
Cocaine response after cond. not corrected3.74.14.5-2.02.1-1.9
Cocaine response before conditioning0.30.40.60.7-0.70.5
Saline control response0.30.40.5-0.70.6-0.5
Bone: connectivity density1.72.73.80.7-1.91.9
Bone: cortical apparent density0.30.40.7-0.90.6-0.3
Bone: cortical area0.81.32.0-0.6-1.21.4
Bone: cortical porosity0.40.40.6-0.1-0.80.8
Bone: cortical porosity0.70.81.2-0.2-1.01.1
Bone: cortical thickness0.40.61.5-1.2-0.30.5
Bone: cortical thickness0.60.71.0-1.00.8-0.7
Bone: cortical tissue density0.20.30.4-0.60.6-0.3
Condit. Reinf. active minus inactive responses0.80.91.81.3-0.80.4
Condit. Reinf. active-inactive response ratio0.10.10.20.10.3-0.4
Condit. Reinf. active responses2.22.73.92.0-1.61.2
Condit. Reinf. inactive responses2.12.52.91.6-1.71.5
Incentive salience index mean1.51.82.31.5-1.41.1
Condit. Reinf. lever presses2.63.54.21.5-2.12.0
Condit. Reinf. active minus inactive responses0.60.71.31.10.4-0.8
Condit. Reinf. active-inactive response ratio1.31.42.30.21.4-1.5
Condit. Reinf. active responses0.30.41.21.1-0.30.0
Condit. Reinf. inactive responses0.50.60.80.6-0.90.8
Condit. Reinf. lever presses0.60.82.11.40.1-0.6
Condit. Reinf. lever reinforcers received0.20.30.70.80.0-0.3
Conditioned reinforcement - actives0.30.30.50.2-0.70.7
Conditioned reinforcement - inactives1.61.82.1-1.31.4-1.3
Conditioned locomotion0.81.01.71.3-0.90.6
Patch foraging indifference point 0 sec1.21.95.6-2.40.30.3
Patch foraging indifference point AUC0.20.20.50.7-0.1-0.1
Delay disc. indifference point, 0s delay1.41.62.7-0.5-1.31.6
Delay disc. indifference point, 16s delay0.20.20.40.6-0.30.2
Delay disc. indifference point, 2s delay0.40.40.7-0.4-0.70.9
Delay disc. indifference point, 24s delay0.10.10.3-0.6-0.00.1
Delay disc. indifference point, 4s delay1.11.21.50.8-1.21.2
Delay disc. indifference point, 8s delay0.30.30.5-0.20.7-0.7
Indifference point function ln k0.00.10.1-0.40.2-0.0
Indifference point function log k0.00.10.1-0.40.2-0.0
Patch foraging total patch changes 0 sec1.32.15.9-2.40.50.1
Patch foraging total patch changes 12 sec1.62.13.7-1.91.3-1.0
Patch foraging total patch changes 18 sec0.00.00.0-0.10.00.0
Patch foraging total patch changes 24 sec0.10.10.2-0.5-0.10.3
Patch foraging total patch changes 6 sec0.71.13.0-1.70.5-0.0
Patch foraging time to switch 0 sec0.20.30.6-0.2-0.50.7
Patch foraging water rate 0 sec0.81.31.6-1.01.3-1.2
Patch foraging water rate 12 sec1.21.92.1-1.41.4-1.3
Patch foraging water rate 18 sec2.43.35.1-0.62.1-2.3
Patch foraging water rate 24 sec5.07.08.8-2.13.0-2.8
Patch foraging water rate 6 sec0.81.22.10.11.2-1.5
Seeking ratio, delayed vs. immediate footshock1.71.92.41.5-1.31.3
Distance traveled before self-admin0.30.30.50.5-0.70.4
Distance traveled after self-admin0.20.20.30.4-0.50.5
Extensor digitorum longus weight2.811.119.2-4.43.1-2.1
Bone: elastic displacement0.10.10.1-0.2-0.20.4
Bone: elastic work0.40.50.8-0.9-0.50.7
Bone: endosteal estimation0.30.61.0-1.0-0.50.7
Bone: endosteal perimeter0.81.62.30.6-1.51.4
Epididymis fat weight0.00.10.1-0.20.2-0.4
Delta time in closed arm before/after self-admin5.04.95.8-1.82.4-2.3
Delta time in open arm before/after self-admin0.20.20.5-0.7-0.10.2
Diff in mean of infusions in LGA sessions0.50.61.61.2-0.3-0.0
Delay discount exponential model param0.10.10.2-0.20.4-0.4
Extinction: sum of active levers before priming0.70.71.20.80.6-1.1
Active lever presses in extinction session 60.60.61.01.0-0.80.5
Bone: final force0.81.32.4-1.6-0.61.1
Bone: final moment0.81.42.5-1.6-0.71.1
Food consumed during 24 hour testing period0.30.41.2-1.10.2-0.0
Glucose0.71.12.9-1.70.6-0.1
Heart weight0.20.30.4-0.30.6-0.6
Delay discount hyperbolic model param0.10.10.20.00.4-0.5
Intermittent access intake day 1-15 change0.10.10.10.10.2-0.3
Intermittent access intake escalation1.21.21.8-0.41.2-1.4
Intermittent access intake escalation 20.60.61.10.20.9-1.0
Intermitt. access day 1 inactive lever presses1.01.11.6-0.41.3-1.3
Intermitt. access day 15 inactive lever presses0.40.50.60.80.6-0.7
Intermitt. access escalation Index1.71.52.00.8-1.41.4
Intermittent access day 1 total infusions0.10.10.1-0.3-0.10.3
Intermittent access day 15 total infusions0.20.20.2-0.50.5-0.3
Intermittent access terminal intake (last 3 days)0.10.10.2-0.2-0.30.5
Intermittent access total infusions0.10.10.4-0.60.3-0.1
Intermittent access day 1 locomotion0.00.00.10.10.2-0.2
Intermittent access day 15 total locomotion0.20.20.50.70.1-0.3
Intermittent access total locomotion0.20.20.60.8-0.30.1
Intermittent access standard deviation0.10.10.20.10.4-0.5
Left kidney weight0.61.62.50.6-1.41.6
Right kidney weight0.41.21.81.4-1.00.9
Cocaine induced anxiety2.32.62.81.7-1.71.5
Post-drug Anxiety2.73.03.91.1-2.01.9
Baseline Anxiety0.20.20.3-0.20.4-0.5
Tail length1.85.415.63.9-0.6-0.5
Length with tail1.03.69.33.0-1.10.5
Length without tail0.30.71.20.0-0.91.1
Times rat made contact with spout1.01.21.8-1.31.0-0.8
Lifetime Intake0.20.30.7-0.8-0.10.3
Liver weight, left1.32.13.8-2.01.3-1.0
Liver weight, right0.10.20.5-0.70.4-0.2
Locomotor activity3.25.09.53.1-1.91.3
Locomotor testing distance1.11.93.31.8-1.20.9
Locomotor testing rearing0.10.10.2-0.00.4-0.5
Locomotion in novel chamber0.20.30.8-0.90.3-0.2
Locomotion in novel chamber post-restriction0.91.12.71.6-0.80.4
Fecal boli incidents, locomotor time 11.51.61.9-1.21.4-1.2
Change in fecal boli incidents, locomotor task2.32.22.51.3-1.61.5
Time >=10cm from walls, locomotor time 10.60.61.1-0.3-0.81.0
Bouts of movement, locomotor time 10.10.20.40.7-0.0-0.2
Total resting periods, locomotor time 10.50.51.41.2-0.40.1
Rest time, locomotor task time 10.60.61.21.1-0.70.5
Distance moved, locomotor task time 10.60.71.1-0.6-0.81.0
Vertical activity count, locomotor time 10.70.71.5-1.20.7-0.4
Time >=10cm from walls, locomotor time 21.21.32.3-1.51.0-0.7
Bouts of movement, locomotor time 21.21.31.61.0-1.31.2
Total resting periods, locomotor time 21.51.62.01.1-1.41.3
Rest time, locomotor task time 20.70.81.00.7-1.01.0
Distance moved, locomotor task time 20.70.80.9-0.81.0-1.0
Vertical activity count, locomotor time 22.32.52.8-1.61.7-1.5
Light reinforcement 11.63.06.22.5-1.40.8
Light reinforcement 20.20.30.40.6-0.60.4
Bone: marrow area0.20.50.9-1.0-0.40.7
Bone: maximum diameter1.52.73.61.2-1.91.7
Bone: maximum force0.81.43.3-1.8-0.40.9
Bone: maximum moment0.81.43.3-1.8-0.50.9
Mean time between licks in bursts0.10.20.30.40.3-0.6
Mean num. licks in bursts0.70.81.41.2-0.80.6
Cd content in liver0.30.41.0-1.00.30.0
Co content in liver0.50.61.51.20.3-0.4
Cu content in liver1.31.63.3-0.6-1.01.8
Fe content in liver0.80.91.1-1.11.0-0.9
K content in liver1.11.11.40.8-1.21.1
Mg content in liver1.41.42.00.8-1.41.3
Mn content in liver4.34.97.11.0-2.72.6
Na content in liver0.30.30.5-0.0-0.60.7
Rb content in liver0.81.01.9-0.3-1.01.4
Se content in liver0.10.20.30.1-0.40.6
Sr content in liver1.31.22.3-0.11.2-1.5
Zn content in liver1.71.93.10.81.3-1.8
Bone: minimum diameter0.40.81.4-0.2-1.01.2
Time in familiar zone, hab. session 10.80.82.21.5-0.3-0.3
Time in novel zone, hab. session 11.01.01.4-1.1-0.61.2
Total zone transitions, hab. session 11.72.43.11.1-1.71.8
Total locomotion distance, hab. session 14.46.27.52.1-2.72.6
Locomotion velocity, hab. session 13.44.85.52.1-2.32.1
Time in familiar zone, hab. session 21.11.22.91.70.2-0.7
Time in novel zone, hab. session 21.31.32.9-1.7-0.41.0
Total zone transitions, hab. session 21.52.03.40.2-1.61.8
Total locomotion distance, hab. session 21.62.12.41.4-1.51.4
Locomotion velocity, hab. session 22.33.03.61.6-1.91.8
Novel to familiar place preference ratio1.11.11.8-0.9-0.91.3
Novelty place preference1.01.01.6-0.8-0.91.3
Time in novel zone, NPP test0.91.01.3-1.0-0.71.2
Total zone transitions, NPP test0.40.50.8-0.2-0.80.9
Total locomotion distance, NPP test1.01.31.90.7-1.31.4
Locomotion velocity, NPP test1.11.51.81.0-1.31.3
Intraocular pressure0.50.71.10.21.0-1.0
Delta distance traveled before/after self-admin0.10.10.10.3-0.10.3
Delta ambulatory time before/after self-admin0.30.30.60.3-0.60.8
Parametrial fat weight0.10.20.5-0.30.4-0.7
Pavlov. Cond. lever latency1.21.61.7-1.21.3-1.3
Pavlov. Cond. magazine entry latency0.60.72.11.4-0.2-0.2
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.10.1
Pavlov. Cond. index score1.01.21.81.3-1.10.9
Pavlov. Cond. latency score1.51.92.41.6-1.41.2
Pavlov. Cond. lever contacts1.72.12.61.1-1.61.6
Pavlov. Cond. magazine entry number0.30.30.9-0.90.3-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.0-0.20.8-1.0
Pavlov. Cond. lever-magazine prob. diff.1.01.21.81.3-1.00.9
Pavlov. Cond. response bias0.40.51.11.1-0.50.3
Pavlov. Cond. lever latency0.60.81.8-1.30.6-0.3
Pavlov. Cond. magazine entry latency1.01.12.51.6-0.80.4
Pavlov. Cond. change in total contacts0.10.10.40.6-0.20.0
Pavlov. Cond. index score0.60.71.81.3-0.60.2
Pavlov. Cond. latency score0.81.02.11.5-0.80.4
Pavlov. Cond. lever contacts0.30.41.11.0-0.2-0.1
Pavlov. Cond. magazine entry number0.81.02.2-1.50.8-0.4
Pavlov. Cond. intertrial magazine entries0.60.81.1-0.71.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.01.4-0.70.3
Pavlov. Cond. response bias0.50.72.01.4-0.3-0.1
Time in closed arm before self-admin0.91.11.70.5-1.11.3
Time in closed arm after self-admin0.10.10.2-0.40.10.1
Time in open arm before self-admin0.20.20.4-0.20.5-0.6
Time in open arm after self-admin1.01.12.0-1.40.9-0.7
Bone: periosteal estimation0.71.52.4-0.8-1.21.5
Bone: periosteal perimeter1.11.92.90.3-1.61.7
Bone: post-yield work0.00.00.1-0.30.2-0.1
Progressive ratio test 1 active lever presses0.50.51.1-1.00.6-0.5
Progressive ratio test 1 breakpoint0.50.51.2-1.10.5-0.4
Progressive ratio test 1 inactive lever presses0.00.00.10.2-0.20.1
Progressive ratio test 2 active lever presses0.00.00.1-0.30.1-0.0
Progressive ratio test 2 breakpoint0.20.20.30.3-0.50.6
Progressive ratio test 2 inactive lever presses0.10.10.2-0.1-0.40.5
Incentive Sensitization - Responses0.10.10.30.5-0.20.1
Incentive Sensitization - Breakpoint0.30.30.50.7-0.40.4
Sum of active levers in priming session hrs 5-60.00.00.00.0-0.1-0.1
Progressive ratio0.50.61.0-1.00.8-0.5
Food seeking constrained by brief footshock0.50.71.71.3-0.50.2
Seeking ratio, punishment vs. effort0.70.92.21.5-0.70.2
Retroperitoneal fat weight1.13.57.5-2.71.5-0.8
Reaction time number correct1.82.64.2-2.01.5-1.3
Reaction time mean minus median1.41.94.82.2-0.80.5
Reaction time mean minus median AUC3.44.56.22.5-2.01.7
Reaction time num false alarms0.20.30.4-0.60.7-0.5
Reaction time num false alarms AUC0.60.81.1-0.81.0-0.9
Reaction time trials correct on left1.82.64.2-2.01.5-1.3
Reaction time trials on left1.72.44.0-2.01.4-1.2
Reaction time mean1.92.74.72.2-1.41.2
Reaction time mean AUC1.41.92.81.7-1.31.1
Median of all reaction times1.21.72.51.6-1.21.0
Reaction time omissions0.10.10.20.1-0.40.4
Reaction time false alarm rate0.00.00.10.3-0.00.1
Reaction time premature initiation rate0.81.01.91.40.5-0.9
Reaction time premature initiations1.11.62.70.21.4-1.7
Std. dev. reaction times1.41.93.81.9-1.10.9
Reaction time trials completed1.72.44.0-2.01.4-1.2
Reaction time trials AUC2.23.14.7-2.21.6-1.4
Run reversals in cocaine runway, females1.31.22.01.4-1.00.8
Run reversals in cocaine runway, males1.81.72.71.6-1.20.9
Latency to leave start box in cocaine runway1.71.82.90.5-1.51.7
Latency to leave start box in cocaine runway, F2.83.14.80.5-2.02.2
Latency to leave start box in cocaine runway, M0.40.40.8-0.10.9-0.6
Std. dev. time between licks in bursts1.11.31.70.7-1.31.3
Total sessions with >9 infusions1.21.42.3-0.2-1.31.5
Short access day 1 total inactive lever presses0.00.00.10.0-0.20.2
Short access day 10 total inactive lever presses0.50.60.9-0.10.9-1.0
Short access day 1 total infusions1.11.22.0-0.2-1.21.4
Short access day 10 total infusions0.20.20.7-0.80.10.2
Short access total infusions0.70.71.0-0.7-0.81.0
Short access day 1 locomotion0.40.50.50.6-0.70.7
Short access day 10 total locomotion0.40.51.01.00.3-0.5
Short access total locomotion0.20.20.30.5-0.40.3
One hour access (0.3 mA shock)0.10.10.3-0.60.20.0
Compulsive drug intake0.00.00.1-0.2-0.10.3
One hour access (shock baseline)0.50.60.8-0.90.8-0.7
Social response proportion0.80.91.41.2-0.90.7
Social responses5.77.415.03.9-2.21.4
Social time0.40.60.7-0.90.8-0.6
Soleus weight1.74.911.0-3.31.8-0.9
Bone: stiffness1.01.54.5-2.10.10.4
Tibialis anterior weight0.41.33.0-1.70.8-0.5
Time to tail flick, vehicle, before self-admin4.14.24.71.9-2.22.1
Time to tail flick, vehicle, after self-admin0.50.61.00.20.8-1.0
Time to tail flick, test, before self-admin2.62.52.91.7-1.61.4
Time to tail flick, test, after self-admin1.01.01.50.3-1.21.2
Delta time to tail flick, vehicle, before/after SA3.63.64.3-1.52.1-2.0
Delta time to tail flick, test, before/after SA0.50.40.5-0.60.6-0.7
Tibia length0.41.23.61.9-0.3-0.1
Ambulatory time before self-admin0.10.10.10.1-0.30.2
Ambulatory time after self-admin0.10.10.20.1-0.30.4
Bone: tissue strength1.81.75.0-2.20.30.2
Total heroin consumption0.91.01.41.2-1.10.7
Bone: trabecular number2.33.54.51.5-2.12.0
Bone: trabecular spacing4.25.57.3-1.42.7-2.7
Bone: trabecular thickness6.88.112.01.0-3.43.5
Bone: trabecular tissue density3.24.47.3-2.72.0-1.4
Water consumed over 24 hours0.70.81.3-0.6-0.81.1
Number of responses in last shaping day0.40.41.11.1-0.40.2