Hub : Genes

LOC108349043

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC108349043	0.18	0.09	2.2e-07	0.05	0.06	0.06	0.05	3.7e-06	3.2e-07	2.4e-07	8.1e-06
2	NAcc	gene expression	LOC108349043	0.06	0.04	1.9e-06	0.05	0.05	0.03	0.05	1.6e-06	1.2e-06	7.4e-05	1.5e-06
3	LHb	gene expression	LOC108349043	0.15	0.12	5.4e-03	0.05	0.04	0.03	0.05	2.1e-02	3.4e-02	5.3e-02	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.5	0.8	0.1	-0.9	0.8
Area under the delay curve	0.7	0.7	1.3	-0.4	1.1	-0.8
BMI with tail	1.2	3.9	6.3	-0.7	2.5	-2.2
BMI without tail	0.9	1.9	2.7	-0.8	1.6	-1.5
Body weight	5.2	21.6	27.0	-3.5	5.2	-5.0
Weight adjusted by age	0.6	0.7	1.2	0.3	0.9	-1.1
Bone surface	0.0	0.0	0.0	-0.1	-0.0	-0.1
Bone volume	0.1	0.1	0.2	-0.5	0.2	-0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.4	0.3	-0.6	0.5
Number of licking bursts	0.5	0.5	0.7	0.6	-0.8	0.7
Context. condit. distance diff. score	0.5	0.6	0.8	0.9	-0.6	0.7
Locomotion velocity, session 1	0.4	0.4	0.6	0.2	-0.8	0.8
Locomotion distance, session 1	3.0	3.8	4.5	1.6	-2.1	2.1
Locomotion velocity, session 2	0.2	0.2	0.3	0.4	-0.5	0.5
Locomotion distance, session 2	0.8	1.1	1.3	1.0	-1.1	1.1
Locomotion velocity, session 3	1.2	1.4	2.9	-1.7	0.8	-0.8
Locomotion distance, session 3	0.1	0.1	0.3	0.0	-0.4	0.5
Stereotopy head waving bouts, day 3	2.0	2.3	2.4	-1.5	1.5	-1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.1	0.3	-0.3
Locomotion velocity, session 7	0.1	0.1	0.3	-0.5	-0.1	0.1
Locomotion distance, session 7	0.6	0.7	1.0	0.5	-1.0	1.0
Stereotopy head waving bouts, day 7	0.8	0.9	1.5	-1.2	0.8	-0.8
Stereotopy head waving duration, day 7	1.8	2.2	2.9	-1.7	1.3	-1.4
Locomotion velocity, session 8	0.0	0.0	0.0	0.0	-0.0	0.1
Locomotion distance, session 8	0.9	1.3	1.4	1.1	-1.1	1.2
Degree of sensitization distance	0.1	0.1	0.3	0.5	-0.1	0.1
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.9	0.1	-0.2
Conditioned locomotion	3.1	3.7	4.1	-2.0	1.8	-1.9
Cocaine response after cond. corrected	0.4	0.5	0.6	0.6	0.8	-0.7
Cocaine response after cond. not corrected	0.4	0.4	0.7	0.4	0.8	-0.7
Cocaine response before conditioning	0.2	0.2	0.6	-0.8	0.1	-0.1
Saline control response	0.5	0.7	0.9	-0.8	0.9	-0.8
Bone: connectivity density	0.2	0.4	0.6	0.1	-0.8	0.7
Bone: cortical apparent density	0.1	0.2	0.6	-0.7	0.1	-0.1
Bone: cortical area	0.2	0.3	0.5	0.4	0.7	-0.4
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.0	0.0
Bone: cortical porosity	0.1	0.1	0.2	0.5	-0.1	0.1
Bone: cortical thickness	0.2	0.3	0.7	0.8	-0.3	0.5
Bone: cortical thickness	0.0	0.0	0.0	-0.2	0.1	-0.1
Bone: cortical tissue density	0.2	0.3	0.7	-0.8	0.2	-0.2
Condit. Reinf. active minus inactive responses	0.6	0.7	0.9	0.5	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	-0.2	0.3
Condit. Reinf. active responses	0.1	0.2	0.2	-0.5	-0.4	0.3
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.7	-0.4	0.3
Incentive salience index mean	0.2	0.2	0.4	0.1	-0.6	0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	0.3	-1.0	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.3	-0.6	0.5
Condit. Reinf. active responses	0.5	0.6	0.9	0.4	-0.9	1.0
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.6	0.3	-0.1
Condit. Reinf. lever presses	3.5	4.7	5.9	1.9	-2.2	2.4
Condit. Reinf. lever reinforcers received	1.1	1.6	2.1	0.9	-1.3	1.5
Conditioned reinforcement - actives	0.5	0.5	0.6	-0.7	0.7	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.1	-0.3	0.3
Conditioned locomotion	0.4	0.5	0.7	-0.4	0.8	-0.8
Patch foraging indifference point 0 sec	0.2	0.3	0.4	-0.4	0.7	-0.6
Patch foraging indifference point AUC	0.0	0.0	0.0	0.0	-0.1	0.2
Delay disc. indifference point, 0s delay	0.5	0.5	1.5	1.2	0.3	-0.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.8	0.6	-0.3
Delay disc. indifference point, 2s delay	0.4	0.4	0.9	0.9	-0.3	0.5
Delay disc. indifference point, 24s delay	2.1	2.0	3.0	-1.0	1.7	-1.4
Delay disc. indifference point, 4s delay	1.0	1.0	1.5	-0.6	1.2	-1.1
Delay disc. indifference point, 8s delay	1.8	1.9	2.4	-1.3	1.5	-1.3
Indifference point function ln k	0.2	0.3	0.5	0.7	-0.4	0.4
Indifference point function log k	0.2	0.3	0.5	0.7	-0.4	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.3	0.6	-0.5
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	0.4	-0.1	0.2
Patch foraging total patch changes 18 sec	0.6	0.8	0.9	-0.9	1.0	-0.7
Patch foraging total patch changes 24 sec	0.6	0.8	1.2	1.1	-0.7	0.8
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.0	0.2	-0.1
Patch foraging time to switch 0 sec	0.8	1.3	1.7	-0.8	1.3	-1.2
Patch foraging water rate 0 sec	0.5	0.8	1.5	1.2	-0.7	0.7
Patch foraging water rate 12 sec	0.1	0.1	0.2	0.3	-0.4	0.4
Patch foraging water rate 18 sec	0.3	0.4	0.6	0.1	-0.8	0.7
Patch foraging water rate 24 sec	0.4	0.5	0.6	0.8	-0.6	0.8
Patch foraging water rate 6 sec	0.3	0.4	0.5	0.7	-0.4	0.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.5	-1.2	0.2	-0.0
Distance traveled before self-admin	0.7	0.7	0.8	-0.7	0.9	-0.9
Distance traveled after self-admin	0.1	0.1	0.2	-0.5	0.2	-0.4
Extensor digitorum longus weight	0.2	0.6	0.8	0.6	-0.9	0.9
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.2	0.2
Bone: elastic work	0.0	0.0	0.1	0.3	0.1	-0.0
Bone: endosteal estimation	2.8	6.1	7.6	-1.9	2.8	-2.7
Bone: endosteal perimeter	1.3	2.7	3.8	-0.9	1.9	-1.9
Epididymis fat weight	1.0	2.4	3.4	-0.9	1.8	-1.7
Delta time in closed arm before/after self-admin	1.0	1.0	1.7	-0.2	1.1	-1.3
Delta time in open arm before/after self-admin	0.6	0.6	0.9	0.5	-0.8	1.0
Diff in mean of infusions in LGA sessions	1.0	1.1	1.1	1.1	-1.1	1.1
Delay discount exponential model param	0.6	0.6	1.1	0.5	-1.0	0.7
Extinction: sum of active levers before priming	0.3	0.3	0.5	0.7	-0.6	0.4
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	0.2	0.1
Bone: final force	3.6	5.8	7.3	-1.8	2.7	-2.6
Bone: final moment	2.8	4.5	6.3	-1.5	2.5	-2.3
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.1	0.7	-0.6
Glucose	0.3	0.5	1.4	1.2	0.0	0.1
Heart weight	2.6	3.7	4.4	2.1	-1.9	1.7
Delay discount hyperbolic model param	0.3	0.4	0.7	0.3	-0.8	0.5
Intermittent access intake day 1-15 change	2.6	2.6	5.5	-2.4	1.0	-1.1
Intermittent access intake escalation	3.5	3.4	6.8	-2.6	1.2	-1.4
Intermittent access intake escalation 2	0.7	0.7	2.2	-1.5	-0.1	-0.2
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.2	1.1	-0.4	0.3
Intermitt. access day 15 inactive lever presses	2.5	2.8	4.8	-2.2	1.2	-1.4
Intermitt. access escalation Index	0.4	0.4	0.4	0.6	-0.6	0.6
Intermittent access day 1 total infusions	0.2	0.2	0.3	0.3	-0.5	0.6
Intermittent access day 15 total infusions	0.4	0.5	1.2	-1.1	0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.6	-0.8	0.5	-0.6
Intermittent access total infusions	0.0	0.0	0.1	-0.3	-0.2	0.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	0.4	-0.4
Intermittent access day 15 total locomotion	7.3	7.8	11.6	-3.4	2.4	-2.5
Intermittent access total locomotion	3.0	3.4	5.4	-2.3	1.5	-1.6
Intermittent access standard deviation	0.8	0.9	1.1	-0.9	0.9	-1.0
Left kidney weight	2.9	8.1	9.4	-2.5	2.9	-3.1
Right kidney weight	3.9	11.0	12.0	-3.1	3.4	-3.5
Cocaine induced anxiety	0.1	0.2	0.4	-0.7	-0.2	0.1
Post-drug Anxiety	0.2	0.2	0.3	-0.1	-0.6	0.4
Baseline Anxiety	0.9	0.9	2.1	1.4	-0.6	0.6
Tail length	1.4	4.1	4.5	-2.1	1.9	-2.1
Length with tail	2.7	9.8	10.2	-3.2	3.0	-3.2
Length without tail	1.7	3.7	4.1	-1.8	2.0	-2.0
Times rat made contact with spout	2.0	2.3	3.2	0.8	-1.8	1.7
Lifetime Intake	0.1	0.1	0.1	-0.3	0.2	-0.3
Liver weight, left	6.4	10.3	12.4	-3.5	3.0	-3.0
Liver weight, right	2.8	4.6	4.6	-2.2	2.1	-2.2
Locomotor activity	0.1	0.1	0.2	-0.3	0.4	-0.2
Locomotor testing distance	0.1	0.1	0.4	0.6	-0.0	0.2
Locomotor testing rearing	0.8	1.2	1.6	-0.8	1.3	-1.1
Locomotion in novel chamber	1.4	1.7	3.6	1.9	-0.8	1.0
Locomotion in novel chamber post-restriction	2.0	2.4	2.5	-1.4	1.6	-1.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	-0.1
Change in fecal boli incidents, locomotor task	1.1	1.0	3.0	1.7	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.3	-0.4	1.1	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	-0.4	0.4
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.3	-0.1	0.1
Rest time, locomotor task time 1	0.1	0.1	0.1	0.2	0.3	-0.3
Distance moved, locomotor task time 1	0.3	0.3	0.5	-0.7	0.4	-0.4
Vertical activity count, locomotor time 1	0.8	0.8	1.0	-1.0	0.8	-0.9
Time >=10cm from walls, locomotor time 2	3.4	3.6	5.6	-0.4	2.4	-2.2
Bouts of movement, locomotor time 2	0.6	0.6	1.6	-1.3	0.4	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.5	-0.1	0.1
Rest time, locomotor task time 2	0.0	0.1	0.2	0.4	-0.0	-0.0
Distance moved, locomotor task time 2	2.4	2.8	3.3	-1.8	1.6	-1.6
Vertical activity count, locomotor time 2	1.6	1.7	2.2	-1.5	1.1	-1.3
Light reinforcement 1	2.0	3.7	4.4	-1.7	1.9	-2.1
Light reinforcement 2	2.6	3.5	3.9	-1.7	1.9	-2.0
Bone: marrow area	2.9	6.3	7.8	-2.0	2.8	-2.7
Bone: maximum diameter	0.2	0.4	0.8	0.2	0.9	-0.7
Bone: maximum force	1.3	2.3	3.0	-1.1	1.7	-1.6
Bone: maximum moment	0.9	1.5	2.2	-0.7	1.5	-1.3
Mean time between licks in bursts	0.4	0.6	0.8	0.5	-0.9	0.8
Mean num. licks in bursts	0.1	0.1	0.2	-0.0	-0.4	0.5
Cd content in liver	1.5	1.7	2.2	-1.5	1.2	-1.2
Co content in liver	2.0	2.4	2.9	-1.3	1.6	-1.7
Cu content in liver	3.2	3.9	4.4	1.8	-2.1	2.0
Fe content in liver	5.0	6.0	6.8	-2.6	2.3	-2.4
K content in liver	1.2	1.2	1.4	1.1	-1.2	1.0
Mg content in liver	3.4	3.4	4.5	2.1	-1.7	1.7
Mn content in liver	0.1	0.2	0.3	0.6	-0.3	0.3
Na content in liver	0.1	0.1	0.3	-0.6	-0.3	-0.0
Rb content in liver	0.1	0.1	0.1	0.1	0.4	-0.3
Se content in liver	2.8	3.5	3.8	1.8	-2.0	1.8
Sr content in liver	0.0	0.0	0.1	0.3	-0.2	0.2
Zn content in liver	0.9	1.0	2.0	1.4	0.8	-0.5
Bone: minimum diameter	0.7	1.4	2.3	0.0	1.5	-1.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.0	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.2	0.5	-0.6
Total zone transitions, hab. session 1	2.0	2.8	3.9	1.1	-2.0	1.8
Total locomotion distance, hab. session 1	1.5	2.2	2.8	1.1	-1.7	1.6
Locomotion velocity, hab. session 1	1.5	2.1	2.7	1.1	-1.6	1.6
Time in familiar zone, hab. session 2	1.3	1.4	1.6	1.1	-1.1	1.3
Time in novel zone, hab. session 2	1.9	1.9	2.3	-1.5	1.3	-1.3
Total zone transitions, hab. session 2	0.4	0.5	0.5	0.6	-0.7	0.7
Total locomotion distance, hab. session 2	2.3	3.0	3.3	1.6	-1.8	1.8
Locomotion velocity, hab. session 2	2.7	3.7	4.1	1.7	-2.0	2.0
Novel to familiar place preference ratio	0.2	0.2	0.3	0.0	0.5	-0.5
Novelty place preference	0.1	0.1	0.2	-0.0	0.5	-0.5
Time in novel zone, NPP test	0.2	0.2	0.3	-0.2	0.6	-0.6
Total zone transitions, NPP test	1.8	2.5	2.7	1.6	-1.5	1.6
Total locomotion distance, NPP test	1.6	2.2	2.5	1.6	-1.4	1.5
Locomotion velocity, NPP test	2.4	3.4	3.9	2.0	-1.8	1.8
Intraocular pressure	1.3	1.8	2.1	-1.3	1.4	-1.3
Delta distance traveled before/after self-admin	0.4	0.5	0.6	0.5	-0.8	0.7
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	0.3	-0.9	0.7
Parametrial fat weight	3.1	6.0	8.7	-2.9	2.1	-2.2
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	0.7	-0.6
Pavlov. Cond. magazine entry latency	0.7	1.0	1.5	1.2	-0.7	0.9
Pavlov. Cond. change in total contacts	0.6	0.6	0.7	-0.8	0.8	-0.7
Pavlov. Cond. index score	0.4	0.5	1.1	1.0	-0.4	0.6
Pavlov. Cond. latency score	0.4	0.5	1.2	1.1	-0.3	0.5
Pavlov. Cond. lever contacts	0.3	0.4	0.5	0.7	-0.6	0.6
Pavlov. Cond. magazine entry number	1.3	1.6	2.2	-1.5	1.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	-0.8	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.9	-0.4	0.5
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	-1.1	1.2
Pavlov. Cond. lever latency	1.8	2.4	3.4	-1.2	1.5	-1.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	-0.8	0.5	-0.4
Pavlov. Cond. change in total contacts	1.0	1.4	2.1	0.8	-1.3	1.4
Pavlov. Cond. index score	0.3	0.4	0.7	0.1	-0.7	0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	0.0	-0.5	0.6
Pavlov. Cond. lever contacts	1.0	1.4	2.3	0.6	-1.2	1.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.4	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.0	-0.4	0.6
Pavlov. Cond. response bias	0.5	0.7	1.3	0.2	-0.9	1.1
Time in closed arm before self-admin	0.9	1.0	1.8	1.3	-0.8	0.7
Time in closed arm after self-admin	0.2	0.2	0.6	0.8	0.1	-0.2
Time in open arm before self-admin	0.3	0.4	0.9	-0.9	-0.4	0.3
Time in open arm after self-admin	1.0	1.1	1.8	-0.1	-1.3	1.3
Bone: periosteal estimation	1.6	3.3	4.7	-1.1	2.2	-2.0
Bone: periosteal perimeter	0.5	0.8	1.5	-0.1	1.2	-1.0
Bone: post-yield work	0.2	0.3	0.3	-0.5	0.5	-0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	-0.1	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	0.7	-0.2	0.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.0	-1.0	1.0	-1.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.5	0.0	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.5	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.8	-0.9	-0.5	0.2
Incentive Sensitization - Responses	0.5	0.5	0.8	-0.0	-0.9	0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	-0.4	-0.6	0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.6	-0.7	0.4
Progressive ratio	5.1	5.9	9.2	-3.0	2.1	-2.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.4	-0.2	0.4
Seeking ratio, punishment vs. effort	4.1	5.1	8.8	3.0	-1.8	1.8
Retroperitoneal fat weight	1.0	3.2	4.2	-1.1	2.1	-2.0
Reaction time number correct	1.0	1.5	2.3	-1.5	1.1	-1.0
Reaction time mean minus median	1.3	1.7	4.2	-2.1	0.5	-0.7
Reaction time mean minus median AUC	0.9	1.1	2.7	-1.7	0.6	-0.6
Reaction time num false alarms	0.1	0.1	0.2	0.1	-0.4	0.3
Reaction time num false alarms AUC	0.6	0.8	1.0	0.8	-1.0	0.8
Reaction time trials correct on left	1.0	1.5	2.3	-1.5	1.1	-1.0
Reaction time trials on left	1.0	1.5	2.3	-1.5	1.0	-1.0
Reaction time mean	0.3	0.5	0.7	-0.9	0.6	-0.5
Reaction time mean AUC	0.8	1.1	1.8	-1.3	0.9	-0.9
Median of all reaction times	0.2	0.3	0.4	-0.4	0.6	-0.5
Reaction time omissions	0.4	0.6	1.6	-1.3	0.2	-0.3
Reaction time false alarm rate	1.6	2.3	2.7	1.6	-1.5	1.3
Reaction time premature initiation rate	0.2	0.3	0.4	0.6	-0.6	0.4
Reaction time premature initiations	0.1	0.1	0.1	-0.4	0.1	-0.3
Std. dev. reaction times	0.3	0.5	1.2	-1.1	0.2	-0.3
Reaction time trials completed	1.0	1.5	2.3	-1.5	1.0	-1.0
Reaction time trials AUC	1.0	1.5	2.4	-1.5	1.0	-1.0
Run reversals in cocaine runway, females	0.4	0.4	0.7	-0.9	0.6	-0.4
Run reversals in cocaine runway, males	3.4	3.3	9.1	-3.0	0.5	-0.7
Latency to leave start box in cocaine runway	2.1	2.2	5.0	2.2	-0.9	0.9
Latency to leave start box in cocaine runway, F	2.0	2.2	4.9	2.2	-0.9	0.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.6	-0.2	0.0
Std. dev. time between licks in bursts	0.7	0.8	2.2	1.5	0.4	-0.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	0.1	-0.0
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.3	0.1	-0.1
Short access day 1 total infusions	1.2	1.3	1.7	1.3	-1.0	1.0
Short access day 10 total infusions	0.0	0.0	0.0	0.0	-0.1	0.0
Short access total infusions	0.0	0.0	0.1	0.3	-0.0	-0.0
Short access day 1 locomotion	0.8	0.8	2.1	1.5	-0.3	0.4
Short access day 10 total locomotion	2.0	2.2	5.1	2.3	-0.9	0.8
Short access total locomotion	0.5	0.5	1.4	1.2	-0.1	0.0
One hour access (0.3 mA shock)	0.5	0.6	1.0	0.3	-1.0	0.9
Compulsive drug intake	4.4	4.4	6.8	2.6	-1.9	1.7
One hour access (shock baseline)	1.3	1.5	3.5	-1.9	0.7	-0.6
Social response proportion	0.3	0.4	1.1	1.1	0.0	0.0
Social responses	0.6	0.7	1.9	1.4	-0.3	0.4
Social time	0.1	0.1	0.2	0.2	-0.4	0.4
Soleus weight	0.2	0.5	0.7	0.3	0.8	-0.8
Bone: stiffness	1.1	1.7	2.3	-1.0	1.5	-1.3
Tibialis anterior weight	1.0	3.3	3.5	1.9	-1.8	1.8
Time to tail flick, vehicle, before self-admin	4.0	4.1	6.9	-2.6	1.7	-1.6
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.0	1.0	-0.4	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.0	-0.2	0.4
Time to tail flick, test, after self-admin	0.9	1.0	2.8	-1.7	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	2.6	2.6	4.6	2.1	-1.2	1.3
Delta time to tail flick, test, before/after SA	2.6	2.3	3.5	-1.9	1.3	-1.3
Tibia length	3.1	8.6	9.4	-3.1	2.8	-3.0
Ambulatory time before self-admin	0.3	0.3	0.4	-0.5	0.6	-0.6
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.1
Bone: tissue strength	0.0	0.0	0.0	0.0	-0.0	0.0
Total heroin consumption	0.3	0.4	0.6	-0.4	-0.8	0.6
Bone: trabecular number	0.7	1.0	1.5	0.5	-1.2	1.2
Bone: trabecular spacing	1.4	1.9	2.4	-0.9	1.5	-1.5
Bone: trabecular thickness	0.7	0.9	1.6	-1.3	0.7	-0.7
Bone: trabecular tissue density	0.2	0.3	0.8	-0.9	0.2	-0.3
Water consumed over 24 hours	1.7	2.1	2.6	1.6	-1.3	1.3
Number of responses in last shaping day	3.5	3.6	8.3	2.9	-1.2	1.0