LOC108349035

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC108349035	0.25	0.11	2.3e-12	0.1	0.11	0.09	0.1	2.2e-11	1.6e-12	1.3e-10	6.0e-11
2	Adipose	alternative polyA	XR_010060762.1	0.12	0.06	5.5e-07	0.03	0.04	0.04	0.04	5.4e-04	2.6e-05	6.0e-05	4.7e-05
3	pVTA	gene expression	LOC108349035	0.15	0.08	3.6e-08	0.12	0.07	0.08	0.09	1.0e-09	4.0e-06	5.9e-07	5.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	1.0	1.9	2.9	-1.6	1.7	-0.4
Area under the delay curve	0.1	0.1	0.2	0.4	-0.4	0.3
BMI with tail	1.3	4.6	11.0	-1.5	0.8	3.3
BMI without tail	0.4	2.2	5.8	-0.8	0.3	2.4
Body weight	1.1	4.7	11.6	0.7	-1.5	3.4
Weight adjusted by age	0.4	1.3	1.6	1.3	-1.3	0.8
Bone surface	0.1	0.2	0.3	0.5	-0.6	-0.3
Bone volume	0.1	0.2	0.3	-0.5	0.5	0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.3	-0.5
Number of licking bursts	0.8	2.4	2.9	1.7	-1.7	-1.2
Context. condit. distance diff. score	3.4	4.1	6.2	1.9	-1.6	-2.5
Locomotion velocity, session 1	1.5	1.7	4.2	0.8	-0.5	-2.0
Locomotion distance, session 1	0.6	0.7	1.0	-0.9	1.0	-0.6
Locomotion velocity, session 2	0.4	0.4	0.7	0.5	-0.5	-0.8
Locomotion distance, session 2	0.0	0.1	0.1	-0.1	0.2	-0.3
Locomotion velocity, session 3	0.5	0.5	0.8	-0.9	0.9	0.1
Locomotion distance, session 3	0.6	0.7	0.9	-0.7	0.9	-0.9
Stereotopy head waving bouts, day 3	1.5	1.7	2.8	1.5	-1.7	-0.1
Stereotopy head waving duration, day 3	0.8	1.0	1.5	1.2	-1.2	-0.3
Locomotion velocity, session 7	0.5	0.6	0.8	-0.5	0.8	-0.9
Locomotion distance, session 7	1.3	1.6	2.8	-0.8	1.2	-1.7
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	0.2	-0.1	-0.9
Stereotopy head waving duration, day 7	0.0	0.1	0.1	0.2	-0.2	-0.3
Locomotion velocity, session 8	5.4	6.5	8.3	2.9	-2.7	-2.0
Locomotion distance, session 8	1.7	2.4	3.6	1.5	-1.2	-1.9
Degree of sensitization distance	0.9	1.0	1.4	1.2	-1.1	-0.6
Degree of sensitization stereotypy	0.5	0.6	1.5	-0.2	0.4	-1.2
Conditioned locomotion	0.8	0.9	1.2	0.8	-1.1	0.9
Cocaine response after cond. corrected	0.2	0.4	0.7	0.3	-0.5	0.9
Cocaine response after cond. not corrected	1.0	1.4	2.2	1.3	-1.5	0.5
Cocaine response before conditioning	1.2	1.5	2.4	1.4	-1.5	-0.2
Saline control response	2.4	3.4	4.1	-1.8	1.6	2.0
Bone: connectivity density	0.3	0.5	0.7	-0.8	0.9	-0.3
Bone: cortical apparent density	1.8	2.8	4.3	-1.6	1.3	2.1
Bone: cortical area	0.1	0.2	0.3	0.4	-0.5	0.2
Bone: cortical porosity	1.1	1.2	3.5	0.3	0.1	-1.9
Bone: cortical porosity	1.8	2.0	4.8	0.9	-0.5	-2.2
Bone: cortical thickness	1.4	2.3	3.1	-1.8	1.5	1.2
Bone: cortical thickness	2.8	3.5	4.1	-2.0	1.7	1.9
Bone: cortical tissue density	1.5	2.5	4.0	-1.5	1.1	2.0
Condit. Reinf. active minus inactive responses	0.6	0.7	1.8	-0.2	0.5	-1.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.7	0.7	-0.0
Condit. Reinf. active responses	0.4	0.6	0.7	-0.6	0.8	-0.8
Condit. Reinf. inactive responses	1.1	1.4	2.3	-1.4	1.5	-0.1
Incentive salience index mean	1.0	1.3	2.9	0.8	-0.5	-1.7
Condit. Reinf. lever presses	1.5	2.3	2.5	1.6	-1.4	-1.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.6	-0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.8	1.2	1.8	1.3	-1.3	-0.4
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	0.1	-0.2
Condit. Reinf. inactive responses	0.5	0.8	1.1	-1.1	1.0	0.6
Condit. Reinf. lever presses	0.5	0.7	1.5	-0.3	0.6	-1.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.1	-0.0	-0.5
Conditioned reinforcement - actives	0.1	0.3	0.4	-0.6	0.7	0.4
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.4	0.5	-0.0
Conditioned locomotion	0.0	0.0	0.1	0.2	0.0	-0.3
Patch foraging indifference point 0 sec	0.8	2.3	4.0	-1.3	1.1	2.0
Patch foraging indifference point AUC	0.1	0.2	0.4	0.4	-0.4	-0.6
Delay disc. indifference point, 0s delay	0.6	0.7	1.0	1.0	-1.0	0.1
Delay disc. indifference point, 16s delay	0.4	0.5	0.7	-0.8	0.8	0.5
Delay disc. indifference point, 2s delay	1.3	1.4	2.2	1.5	-1.4	-0.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	0.1	0.2
Delay disc. indifference point, 4s delay	0.6	0.6	0.8	0.6	-0.8	0.9
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.2	-0.1	0.0
Indifference point function ln k	0.3	0.8	0.9	0.9	-0.8	-1.0
Indifference point function log k	0.3	0.8	0.9	0.9	-0.8	-1.0
Patch foraging total patch changes 0 sec	0.8	2.5	3.9	-1.4	1.2	2.0
Patch foraging total patch changes 12 sec	1.0	1.4	2.3	-1.1	0.9	1.5
Patch foraging total patch changes 18 sec	2.2	5.2	5.8	-2.4	2.1	2.3
Patch foraging total patch changes 24 sec	1.1	3.9	5.3	-2.3	2.3	1.1
Patch foraging total patch changes 6 sec	1.4	2.4	2.8	-1.6	1.4	1.7
Patch foraging time to switch 0 sec	0.6	2.2	4.7	-1.1	0.8	2.2
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.3	-0.4	0.2
Patch foraging water rate 12 sec	0.2	0.8	1.3	-1.1	1.1	0.1
Patch foraging water rate 18 sec	0.2	0.5	1.0	-0.5	0.3	1.0
Patch foraging water rate 24 sec	0.4	0.5	0.6	-0.8	0.6	0.7
Patch foraging water rate 6 sec	0.3	0.4	0.6	-0.7	0.5	0.7
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.2	-0.4	-0.0	1.1
Distance traveled before self-admin	0.2	0.5	0.6	0.5	-0.8	0.8
Distance traveled after self-admin	0.4	0.6	0.8	0.5	-0.9	0.9
Extensor digitorum longus weight	0.3	1.1	1.7	1.3	-1.3	0.1
Bone: elastic displacement	0.6	0.7	1.2	-1.0	1.1	-0.2
Bone: elastic work	0.0	0.0	0.1	-0.2	0.2	0.3
Bone: endosteal estimation	3.5	8.7	13.4	3.6	-3.7	-0.0
Bone: endosteal perimeter	3.0	7.3	10.7	3.3	-3.3	-0.8
Epididymis fat weight	5.7	29.0	34.5	-5.5	4.7	5.9
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.5	-0.7	0.4
Delta time in open arm before/after self-admin	0.3	0.4	0.6	-0.7	0.8	0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.1	0.1	-0.6
Delay discount exponential model param	0.1	0.1	0.2	-0.4	0.4	-0.2
Extinction: sum of active levers before priming	0.6	0.9	1.1	1.0	-1.0	-0.8
Active lever presses in extinction session 6	0.4	0.4	0.7	-0.7	0.8	-0.1
Bone: final force	1.3	2.2	6.1	-0.6	0.1	2.5
Bone: final moment	1.0	1.5	4.3	-0.5	0.2	2.1
Food consumed during 24 hour testing period	0.6	1.3	1.8	1.1	-1.3	0.9
Glucose	6.9	10.9	14.0	3.7	-3.3	-2.7
Heart weight	0.4	0.7	1.1	1.0	-1.0	0.2
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.5	0.5	-0.2
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.0	0.0	0.0
Intermittent access intake escalation	0.1	0.5	0.8	-0.9	0.8	0.3
Intermittent access intake escalation 2	0.1	0.1	0.4	0.2	-0.2	-0.6
Intermitt. access day 1 inactive lever presses	0.2	2.5	4.1	1.8	-2.0	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.2	0.4	-0.5	0.3
Intermitt. access escalation Index	0.1	0.4	0.6	0.4	-0.6	-0.8
Intermittent access day 1 total infusions	0.3	0.8	1.4	-0.4	0.9	-1.2
Intermittent access day 15 total infusions	0.4	0.9	1.6	-1.0	1.3	-0.3
Intermittent access terminal intake (last 3 days)	0.3	0.5	1.0	-0.7	1.0	-0.4
Intermittent access total infusions	0.6	0.7	1.2	-0.7	1.1	-0.6
Intermittent access day 1 locomotion	0.2	0.4	0.8	-0.7	0.9	0.1
Intermittent access day 15 total locomotion	0.1	0.3	0.9	-0.2	0.1	0.9
Intermittent access total locomotion	0.5	0.6	0.8	-0.7	0.9	0.6
Intermittent access standard deviation	0.2	1.3	2.9	-0.8	0.6	1.7
Left kidney weight	0.5	4.0	11.6	-0.4	-0.3	3.4
Right kidney weight	0.6	4.2	12.3	-0.2	-0.5	3.5
Cocaine induced anxiety	0.1	0.4	0.8	0.6	-0.9	-0.0
Post-drug Anxiety	0.3	0.4	0.5	0.4	-0.7	0.7
Baseline Anxiety	0.1	0.1	0.4	0.0	0.0	0.6
Tail length	1.1	6.1	9.3	3.0	-3.0	-0.3
Length with tail	1.8	7.9	12.4	3.3	-3.5	0.8
Length without tail	1.1	6.0	7.1	2.1	-2.7	2.6
Times rat made contact with spout	2.4	2.7	4.3	-1.9	2.1	-0.1
Lifetime Intake	0.4	0.5	0.9	-0.6	0.9	-0.4
Liver weight, left	2.5	4.3	7.0	2.4	-2.6	0.4
Liver weight, right	3.3	5.8	9.0	2.9	-3.0	-0.2
Locomotor activity	0.6	0.9	1.6	1.1	-1.3	-0.1
Locomotor testing distance	0.3	0.8	1.4	1.0	-1.2	0.1
Locomotor testing rearing	0.3	1.1	1.6	1.0	-1.3	0.7
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	0.2	0.5
Locomotion in novel chamber post-restriction	0.2	0.7	2.0	-0.3	0.2	1.4
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.3	0.4	-0.3
Change in fecal boli incidents, locomotor task	2.0	2.1	3.4	1.7	-1.9	0.2
Time >=10cm from walls, locomotor time 1	2.3	2.9	3.9	1.4	-2.0	1.6
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.1	0.1	-0.4
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.1	-0.1	-0.6
Rest time, locomotor task time 1	0.4	0.6	1.0	0.7	-0.6	-1.0
Distance moved, locomotor task time 1	0.2	0.4	1.2	-0.2	0.1	1.1
Vertical activity count, locomotor time 1	0.2	1.5	3.9	-0.6	0.4	2.0
Time >=10cm from walls, locomotor time 2	0.8	2.2	2.8	1.7	-1.6	1.0
Bouts of movement, locomotor time 2	0.0	0.1	0.1	0.3	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.5	0.6	0.7	-0.6	-0.8
Rest time, locomotor task time 2	1.1	1.9	2.9	1.5	-1.7	-0.8
Distance moved, locomotor task time 2	1.0	1.3	2.2	-0.9	1.0	1.5
Vertical activity count, locomotor time 2	0.3	0.8	2.0	-0.4	0.5	1.4
Light reinforcement 1	0.3	1.2	3.6	-0.2	-0.2	1.9
Light reinforcement 2	0.4	0.9	1.8	0.5	-0.8	1.3
Bone: marrow area	3.4	8.5	13.1	3.5	-3.6	0.2
Bone: maximum diameter	2.1	4.3	5.8	2.4	-2.3	-1.3
Bone: maximum force	0.5	1.0	2.8	-0.1	-0.1	1.7
Bone: maximum moment	0.3	0.5	1.6	0.0	-0.2	1.3
Mean time between licks in bursts	0.8	4.8	5.5	2.3	-2.1	-2.1
Mean num. licks in bursts	1.8	4.7	6.5	-2.5	2.6	1.1
Cd content in liver	0.7	0.8	0.9	-0.8	0.9	1.0
Co content in liver	1.1	1.3	2.8	-0.8	0.6	1.7
Cu content in liver	2.4	2.9	4.3	-2.1	2.1	0.2
Fe content in liver	1.1	1.3	1.9	-1.1	1.0	1.4
K content in liver	0.2	0.2	0.5	-0.1	0.1	-0.7
Mg content in liver	2.0	2.2	2.4	1.5	-1.5	-1.5
Mn content in liver	3.9	4.4	6.2	2.5	-2.5	-0.9
Na content in liver	0.4	0.4	0.7	-0.8	0.8	0.1
Rb content in liver	0.0	0.0	0.0	0.1	-0.1	0.1
Se content in liver	3.9	4.6	5.1	2.3	-2.0	-2.1
Sr content in liver	0.4	0.3	0.6	0.8	-0.6	0.0
Zn content in liver	0.3	0.4	0.5	0.7	-0.7	-0.4
Bone: minimum diameter	2.4	4.7	7.1	2.6	-2.7	-0.5
Time in familiar zone, hab. session 1	3.8	4.1	6.8	-2.3	2.6	-0.3
Time in novel zone, hab. session 1	2.5	2.8	4.7	1.9	-2.2	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.4	0.1	-0.0	-0.7
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.1	0.1	-0.4
Locomotion velocity, hab. session 1	0.0	0.1	0.2	0.0	0.0	-0.4
Time in familiar zone, hab. session 2	1.0	1.2	1.8	-1.3	1.1	0.7
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.6	-0.4	-0.3
Total zone transitions, hab. session 2	0.1	0.2	0.4	-0.2	0.0	0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.4	0.2	0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.1	0.0	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.3	0.0	0.2	-0.5
Novelty place preference	0.1	0.1	0.4	0.2	-0.0	-0.6
Time in novel zone, NPP test	0.1	0.2	0.4	0.3	-0.1	-0.6
Total zone transitions, NPP test	0.2	0.2	0.7	-0.1	0.2	-0.8
Total locomotion distance, NPP test	0.1	0.2	0.2	-0.4	0.5	-0.2
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.5	0.6	-0.3
Intraocular pressure	0.8	1.3	2.0	-1.2	1.4	0.7
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.2	-0.2	0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.5	-0.5	-0.1
Parametrial fat weight	1.8	4.1	8.9	-1.6	1.0	3.0
Pavlov. Cond. lever latency	4.8	6.1	11.5	-2.1	1.6	3.4
Pavlov. Cond. magazine entry latency	2.6	3.3	6.7	1.4	-1.0	-2.6
Pavlov. Cond. change in total contacts	1.7	1.9	3.3	1.2	-1.0	-1.8
Pavlov. Cond. index score	4.2	5.3	9.4	2.0	-1.6	-3.1
Pavlov. Cond. latency score	4.5	5.8	9.9	2.1	-1.7	-3.1
Pavlov. Cond. lever contacts	4.2	5.1	7.4	2.2	-1.8	-2.7
Pavlov. Cond. magazine entry number	1.8	2.3	4.9	-1.2	0.8	2.2
Pavlov. Cond. intertrial magazine entries	2.5	3.0	3.5	-1.9	1.8	1.4
Pavlov. Cond. lever-magazine prob. diff.	4.0	5.0	9.1	1.9	-1.4	-3.0
Pavlov. Cond. response bias	2.9	3.6	6.3	1.7	-1.3	-2.5
Pavlov. Cond. lever latency	0.8	1.1	1.8	1.1	-1.3	0.4
Pavlov. Cond. magazine entry latency	0.3	0.5	0.9	0.6	-0.4	-0.9
Pavlov. Cond. change in total contacts	0.2	0.4	0.5	-0.5	0.7	-0.7
Pavlov. Cond. index score	0.2	0.3	0.7	-0.2	0.4	-0.8
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.2	0.4	-0.6
Pavlov. Cond. lever contacts	0.6	0.8	1.4	-1.0	1.2	-0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.0	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.2	0.9	-0.9	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	-0.2	0.4	-0.7
Pavlov. Cond. response bias	0.3	0.4	0.6	-0.4	0.6	-0.8
Time in closed arm before self-admin	0.1	0.2	0.4	0.6	-0.6	-0.2
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	-0.3	0.1
Time in open arm before self-admin	0.5	0.6	1.8	0.3	0.0	-1.3
Time in open arm after self-admin	0.2	0.2	0.6	-0.1	0.3	-0.7
Bone: periosteal estimation	1.7	4.0	6.4	2.4	-2.5	0.3
Bone: periosteal perimeter	1.4	2.9	4.2	2.0	-2.1	-0.5
Bone: post-yield work	1.5	2.6	3.9	2.0	-2.0	-0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.1	0.2	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.3	0.8	0.9	-0.9	0.8	0.9
Progressive ratio test 2 active lever presses	0.3	0.4	0.6	-0.6	0.8	-0.3
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	-0.8	0.9	-0.4
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.3	0.7	-0.5	-1.1
Incentive Sensitization - Responses	0.1	0.2	0.5	-0.3	0.3	-0.7
Incentive Sensitization - Breakpoint	0.1	0.3	0.4	-0.5	0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.6	-0.4	-0.9
Progressive ratio	1.1	3.2	8.7	-0.9	0.3	2.9
Food seeking constrained by brief footshock	0.3	0.3	0.5	-0.7	0.7	0.2
Seeking ratio, punishment vs. effort	1.1	2.4	6.6	0.8	-0.3	-2.6
Retroperitoneal fat weight	0.2	0.9	1.8	-0.8	0.5	1.3
Reaction time number correct	0.5	1.8	2.0	-1.4	1.2	1.3
Reaction time mean minus median	0.4	2.6	5.2	1.3	-1.0	-2.3
Reaction time mean minus median AUC	0.4	2.8	6.3	1.3	-0.8	-2.5
Reaction time num false alarms	0.5	0.8	1.2	1.0	-1.1	-0.4
Reaction time num false alarms AUC	0.5	1.0	1.6	1.2	-1.3	-0.4
Reaction time trials correct on left	0.5	1.8	2.0	-1.4	1.2	1.3
Reaction time trials on left	0.5	1.6	1.8	-1.4	1.2	1.3
Reaction time mean	1.5	3.3	3.6	1.9	-1.6	-1.9
Reaction time mean AUC	1.2	2.8	3.2	1.8	-1.5	-1.8
Median of all reaction times	1.4	2.2	2.8	1.7	-1.5	-1.3
Reaction time omissions	1.0	1.6	2.1	1.4	-1.2	-1.1
Reaction time false alarm rate	2.2	3.0	3.7	1.9	-1.9	-1.3
Reaction time premature initiation rate	0.0	0.1	0.1	0.2	-0.2	0.2
Reaction time premature initiations	0.2	0.6	1.4	-0.5	0.5	1.2
Std. dev. reaction times	1.4	4.5	6.5	2.0	-1.7	-2.6
Reaction time trials completed	0.5	1.6	1.8	-1.4	1.2	1.3
Reaction time trials AUC	0.5	1.6	1.8	-1.4	1.2	1.3
Run reversals in cocaine runway, females	0.8	0.9	1.1	-1.0	1.0	0.8
Run reversals in cocaine runway, males	0.6	0.7	0.9	0.9	-0.7	-0.9
Latency to leave start box in cocaine runway	0.9	1.2	1.3	1.1	-1.1	-1.0
Latency to leave start box in cocaine runway, F	0.5	0.6	0.7	0.8	-0.7	-0.9
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	0.7	-0.8	-0.1
Std. dev. time between licks in bursts	3.6	6.8	8.9	3.0	-2.9	-1.8
Total sessions with >9 infusions	0.1	0.2	0.4	-0.3	0.6	-0.2
Short access day 1 total inactive lever presses	0.5	1.1	1.3	1.1	-0.8	-1.1
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.3	-0.6	0.2
Short access day 1 total infusions	0.2	0.4	1.0	0.3	0.1	-1.0
Short access day 10 total infusions	0.3	0.5	0.9	-0.7	1.0	-0.1
Short access total infusions	0.2	0.2	0.4	-0.2	0.6	-0.6
Short access day 1 locomotion	0.1	0.1	0.3	0.3	-0.1	-0.5
Short access day 10 total locomotion	0.6	2.5	3.6	1.8	-1.9	0.9
Short access total locomotion	0.5	0.7	1.2	1.1	-1.0	0.2
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.4	0.4	-0.7
Compulsive drug intake	1.5	2.2	3.8	1.6	-2.0	-0.5
One hour access (shock baseline)	0.7	1.8	3.3	-1.5	1.8	-0.2
Social response proportion	0.9	1.2	1.9	1.2	-1.4	0.5
Social responses	0.5	0.7	1.2	0.8	-1.1	0.5
Social time	2.2	3.4	5.4	2.1	-2.3	-0.7
Soleus weight	4.3	12.6	18.7	4.3	-4.3	-1.0
Bone: stiffness	0.7	1.2	3.0	-0.7	0.4	1.7
Tibialis anterior weight	0.6	2.0	2.8	-1.4	1.1	1.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.6	0.1	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.5	0.7	-0.5	-0.7
Time to tail flick, test, before self-admin	0.4	0.4	0.7	-0.8	0.7	0.2
Time to tail flick, test, after self-admin	0.9	0.9	1.6	-0.7	0.8	-1.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.3	-0.2	0.7	-1.1
Delta time to tail flick, test, before/after SA	0.1	0.2	0.2	-0.4	0.5	-0.2
Tibia length	2.0	5.6	9.1	2.7	-3.0	0.7
Ambulatory time before self-admin	0.0	0.0	0.1	0.1	-0.2	0.3
Ambulatory time after self-admin	0.2	0.4	0.7	0.5	-0.8	0.4
Bone: tissue strength	0.1	0.1	0.2	0.0	0.0	0.5
Total heroin consumption	0.1	0.1	0.2	0.2	-0.4	-0.2
Bone: trabecular number	1.5	2.8	4.4	-2.0	2.1	-0.4
Bone: trabecular spacing	1.5	2.2	3.4	1.7	-1.8	0.6
Bone: trabecular thickness	1.1	1.6	2.5	-1.5	1.6	0.2
Bone: trabecular tissue density	0.2	0.3	0.8	0.4	-0.1	-0.9
Water consumed over 24 hours	0.3	0.5	0.8	0.8	-0.9	-0.3
Number of responses in last shaping day	2.6	3.4	4.8	2.2	-2.0	-1.2