LOC108349027

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC108349027	0.31	0.21	0.0e+00	0.14	0.17	0.16	0.16	4.3e-15	4.1e-18	1.1e-16	2.2e-17
2	BLA	gene expression	LOC108349027	0.18	0.12	1.7e-05	0.06	0.08	0.06	0.06	2.7e-04	6.8e-05	3.1e-04	4.6e-04
3	Brain	gene expression	LOC108349027	0.2	0.1	6.8e-13	0.11	0.14	0.12	0.12	2.6e-10	4.3e-13	1.0e-11	3.6e-11
4	Liver	gene expression	LOC108349027	0.07	0.05	6.5e-05	0.03	0.03	0.02	0.02	5.2e-04	3.4e-04	6.4e-03	1.8e-03
5	pVTA	gene expression	LOC108349027	0.25	0.19	1.6e-05	0.11	0.09	0.1	0.11	1.9e-05	9.4e-05	6.7e-05	1.6e-05
6	NAcc	gene expression	LOC108349027	0.21	0.09	0.0e+00	0.14	0.2	0.2	0.2	3.1e-16	3.1e-22	3.0e-22	9.4e-23
7	RMTg	gene expression	LOC108349027	0.29	0.15	9.0e-06	0.16	0.16	0.16	0.16	3.9e-05	4.8e-05	3.6e-05	3.5e-05
8	OFC	gene expression	LOC108349027	0.24	0.15	1.0e-03	0.14	0.13	0.05	0.11	3.5e-04	5.9e-04	2.5e-02	1.8e-03
9	Adipose	gene expression	LOC108349027	0.41	0.15	0.0e+00	0.41	0.39	0.41	0.41	1.1e-48	1.1e-45	2.1e-48	1.8e-48

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.2	2.0	4.1	1.7	1.8	1.4	1.3	2.0	0.7	-0.7	-1.6	0.9
Area under the delay curve	1.0	1.0	3.0	0.2	-0.1	0.4	0.6	-0.4	0.9	1.7	1.4	-1.6
BMI with tail	0.8	2.7	7.0	-0.1	-0.3	0.6	0.8	-1.4	1.5	2.6	2.4	-2.5
BMI without tail	1.6	3.3	8.5	-1.2	-1.4	-0.5	-0.2	-2.2	0.7	2.6	2.9	-2.4
Body weight	3.2	13.5	32.7	-3.0	-3.4	-1.6	-1.2	-4.8	0.6	4.6	5.7	-4.5
Weight adjusted by age	1.8	2.1	4.1	-1.6	-1.5	-1.0	-0.8	-2.0	-0.1	1.4	1.9	-1.5
Bone surface	0.2	0.4	0.6	-0.7	-0.8	-0.7	-0.6	-0.8	-0.4	0.2	0.6	-0.1
Bone volume	0.1	0.1	0.3	0.3	0.2	0.3	0.4	0.1	0.5	0.5	0.3	-0.4
Breakpoint value in progressive ratio session	0.4	0.4	1.0	0.5	0.4	0.1	0.0	0.8	-0.4	-0.9	-0.8	1.0
Number of licking bursts	0.9	1.0	2.1	-1.0	-0.9	-1.1	-1.2	-0.6	-1.4	-1.1	-0.5	0.9
Context. condit. distance diff. score	4.8	5.8	12.6	-1.2	-1.0	-2.0	-2.3	0.1	-3.0	-3.5	-2.5	3.5
Locomotion velocity, session 1	0.3	0.4	0.6	-0.6	-0.5	-0.7	-0.7	-0.2	-0.8	-0.6	-0.3	0.7
Locomotion distance, session 1	0.9	1.1	1.9	1.3	1.4	1.2	1.2	1.3	1.0	-0.0	-0.8	0.0
Locomotion velocity, session 2	0.2	0.2	0.4	-0.5	-0.5	-0.6	-0.6	-0.4	-0.5	-0.2	0.2	0.3
Locomotion distance, session 2	0.2	0.3	0.5	0.5	0.6	0.4	0.3	0.7	0.1	-0.5	-0.7	0.5
Locomotion velocity, session 3	0.5	0.6	0.9	0.8	0.8	0.9	0.9	0.7	0.9	0.7	0.2	-0.7
Locomotion distance, session 3	0.7	0.8	1.6	0.8	0.8	0.4	0.3	1.3	-0.2	-1.1	-1.3	1.0
Stereotopy head waving bouts, day 3	1.7	2.0	3.7	-1.8	-1.8	-1.5	-1.4	-1.9	-0.8	0.7	1.5	-0.6
Stereotopy head waving duration, day 3	1.0	1.2	2.3	-1.3	-1.4	-1.0	-1.0	-1.5	-0.5	0.7	1.2	-0.6
Locomotion velocity, session 7	1.9	2.1	5.7	0.7	0.8	0.1	-0.1	1.4	-0.8	-2.2	-2.4	2.1
Locomotion distance, session 7	2.0	2.6	5.8	1.4	1.5	0.8	0.6	2.1	-0.1	-1.9	-2.4	1.9
Stereotopy head waving bouts, day 7	1.0	1.1	3.0	-0.7	-0.8	-0.3	-0.1	-1.2	0.3	1.4	1.7	-1.4
Stereotopy head waving duration, day 7	1.4	1.6	4.0	-1.1	-1.2	-0.6	-0.4	-1.6	0.1	1.6	2.0	-1.6
Locomotion velocity, session 8	4.6	5.5	8.9	-2.7	-2.7	-3.0	-3.0	-2.1	-2.9	-1.4	0.3	1.5
Locomotion distance, session 8	2.4	3.5	8.1	-0.8	-0.6	-1.5	-1.7	0.2	-2.2	-2.8	-2.1	2.8
Degree of sensitization distance	0.6	0.6	1.0	-0.6	-0.6	-0.8	-0.9	-0.3	-0.9	-1.0	-0.6	1.0
Degree of sensitization stereotypy	0.6	0.6	1.7	-0.4	-0.5	-0.1	0.0	-0.8	0.4	1.2	1.3	-1.2
Conditioned locomotion	0.6	0.7	1.4	-1.0	-1.1	-0.8	-0.7	-1.2	-0.4	0.6	0.9	-0.5
Cocaine response after cond. corrected	0.2	0.3	0.6	0.6	0.6	0.4	0.3	0.7	0.0	-0.4	-0.8	0.5
Cocaine response after cond. not corrected	0.5	0.6	0.9	-1.0	-1.0	-0.9	-0.9	-0.9	-0.8	0.0	0.4	0.2
Cocaine response before conditioning	3.8	4.5	8.8	-2.5	-2.6	-2.0	-1.8	-3.0	-0.9	1.5	2.6	-1.4
Saline control response	1.3	1.7	3.3	1.0	0.9	1.4	1.5	0.4	1.8	1.6	1.0	-1.7
Bone: connectivity density	1.1	1.8	4.2	1.0	1.1	0.4	0.3	1.7	-0.4	-1.7	-2.0	1.9
Bone: cortical apparent density	1.8	2.4	4.0	1.5	1.5	1.8	1.9	1.0	2.0	1.5	0.4	-1.6
Bone: cortical area	1.1	1.7	4.3	-0.7	-0.9	-0.2	-0.0	-1.4	0.6	2.0	2.1	-1.8
Bone: cortical porosity	0.4	0.4	1.0	0.3	0.3	0.6	0.7	0.0	0.8	1.0	0.7	-1.0
Bone: cortical porosity	0.4	0.4	0.8	-0.7	-0.8	-0.5	-0.4	-0.9	-0.2	0.6	0.9	-0.6
Bone: cortical thickness	3.6	5.9	11.9	1.6	1.4	2.3	2.5	0.3	3.1	3.4	2.2	-3.3
Bone: cortical thickness	2.7	3.1	5.0	1.8	1.7	2.1	2.2	1.2	2.2	1.8	0.6	-1.7
Bone: cortical tissue density	1.5	1.9	3.2	1.4	1.4	1.7	1.7	0.9	1.8	1.3	0.4	-1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	0.2	0.3	-0.1	-0.1	0.5	-0.3	-1.0	-1.0	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.5	0.5	0.6	0.6	0.5	0.7	0.3	0.1	-0.3
Condit. Reinf. active responses	0.6	0.7	2.2	0.5	0.7	0.2	0.1	1.0	-0.3	-1.2	-1.5	1.1
Condit. Reinf. inactive responses	1.4	1.6	3.4	1.4	1.5	1.0	0.9	1.7	0.3	-1.1	-1.9	1.1
Incentive salience index mean	1.4	1.7	3.6	-0.8	-0.6	-1.2	-1.3	-0.1	-1.6	-1.9	-1.4	1.8
Condit. Reinf. lever presses	2.6	3.5	7.1	-1.2	-1.0	-1.7	-1.9	-0.2	-2.4	-2.7	-1.9	2.5
Condit. Reinf. active minus inactive responses	0.6	0.7	1.5	-0.9	-0.9	-0.5	-0.4	-1.2	-0.0	0.9	1.2	-1.0
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.5	-1.5	-1.6	-1.0	-0.9	-1.9	-0.4	1.1	1.7	-1.2
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	0.1
Condit. Reinf. inactive responses	0.7	0.9	2.1	0.8	0.9	0.4	0.3	1.2	-0.1	-1.2	-1.4	1.2
Condit. Reinf. lever presses	0.2	0.3	1.1	0.3	0.4	0.2	0.1	0.6	-0.2	-0.9	-1.0	0.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.3	-0.1	-0.3	-0.4	-0.3	0.3
Conditioned reinforcement - actives	0.2	0.2	0.9	0.0	-0.1	0.2	0.2	-0.2	0.4	0.6	0.7	-0.9
Conditioned reinforcement - inactives	1.1	1.3	3.8	0.6	0.4	0.8	1.0	0.3	1.2	1.6	1.1	-2.0
Conditioned locomotion	0.1	0.1	0.3	-0.3	-0.4	-0.4	-0.3	-0.3	-0.2	-0.1	0.5	-0.2
Patch foraging indifference point 0 sec	1.5	2.4	4.3	1.5	1.4	1.8	1.8	1.2	2.1	1.4	0.5	-1.7
Patch foraging indifference point AUC	1.1	1.2	2.6	-0.9	-1.0	-0.4	-0.3	-1.4	0.2	1.5	1.6	-1.6
Delay disc. indifference point, 0s delay	0.4	0.4	1.0	-0.7	-0.8	-0.6	-0.5	-1.0	-0.4	0.5	0.8	-0.3
Delay disc. indifference point, 16s delay	2.8	2.8	4.5	1.7	1.3	1.9	2.0	1.0	2.1	1.9	0.6	-2.0
Delay disc. indifference point, 2s delay	1.2	1.3	3.3	-1.0	-1.1	-0.7	-0.5	-1.5	0.0	1.4	1.8	-1.0
Delay disc. indifference point, 24s delay	0.6	0.6	1.3	0.7	0.4	0.7	0.8	0.3	0.9	1.0	0.7	-1.1
Delay disc. indifference point, 4s delay	1.8	1.9	4.5	-1.1	-1.5	-1.0	-0.7	-1.8	-0.2	1.5	2.1	-1.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.2	0.0	0.2	0.3	-0.0	0.4	0.8	0.6	-0.7
Indifference point function ln k	0.5	0.6	1.5	-0.6	-0.5	-0.8	-0.9	-0.2	-0.9	-1.1	-0.6	1.2
Indifference point function log k	0.5	0.6	1.5	-0.6	-0.5	-0.8	-0.9	-0.2	-0.9	-1.1	-0.6	1.2
Patch foraging total patch changes 0 sec	2.0	3.2	5.9	1.7	1.6	2.0	2.1	1.3	2.4	1.7	0.6	-2.0
Patch foraging total patch changes 12 sec	1.9	2.5	4.3	1.4	1.3	1.7	1.9	1.0	2.1	1.7	0.6	-2.0
Patch foraging total patch changes 18 sec	3.7	4.8	7.6	2.6	2.4	2.7	2.8	2.0	2.7	1.5	-0.2	-1.5
Patch foraging total patch changes 24 sec	4.5	5.5	8.5	2.9	2.9	2.8	2.9	2.7	2.5	0.8	-0.9	-0.9
Patch foraging total patch changes 6 sec	2.8	4.2	7.2	2.1	2.0	2.4	2.5	1.6	2.7	1.8	0.4	-2.0
Patch foraging time to switch 0 sec	1.0	1.5	2.7	1.5	1.7	1.5	1.5	1.5	1.1	0.2	-0.6	-0.1
Patch foraging water rate 0 sec	0.2	0.3	0.7	-0.0	-0.1	0.2	0.2	-0.3	0.7	0.8	0.7	-0.7
Patch foraging water rate 12 sec	0.6	0.8	1.6	1.2	1.1	1.1	1.0	1.1	1.3	0.2	-0.4	-0.0
Patch foraging water rate 18 sec	0.2	0.2	0.3	-0.5	-0.5	-0.4	-0.3	-0.6	-0.1	0.4	0.6	-0.6
Patch foraging water rate 24 sec	0.7	1.0	2.3	-0.2	-0.4	0.2	0.3	-0.9	1.0	1.5	1.5	-1.4
Patch foraging water rate 6 sec	0.4	0.5	1.1	0.9	0.8	0.9	0.9	0.7	1.0	0.4	-0.0	0.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	-0.4	-0.5	-0.3	-0.2	-0.4	0.0	0.6	0.8	-0.5
Distance traveled before self-admin	0.6	0.7	1.1	-1.0	-0.9	-1.0	-1.0	-0.8	-1.0	-0.5	0.0	0.5
Distance traveled after self-admin	0.6	0.7	1.3	-1.1	-1.0	-1.0	-1.0	-1.1	-0.8	-0.1	0.2	0.4
Extensor digitorum longus weight	0.3	1.3	2.0	-1.4	-1.4	-1.4	-1.4	-1.3	-1.3	-0.4	0.5	0.3
Bone: elastic displacement	0.6	0.7	1.0	0.9	0.8	1.0	1.0	0.6	1.0	1.0	0.5	-0.7
Bone: elastic work	1.1	1.4	4.2	-0.0	-0.2	0.4	0.6	-0.6	1.0	2.1	1.8	-1.8
Bone: endosteal estimation	5.3	11.6	19.6	-4.3	-4.4	-4.0	-3.9	-4.3	-3.1	0.2	2.4	-0.1
Bone: endosteal perimeter	4.2	8.7	14.0	-3.5	-3.5	-3.7	-3.7	-3.0	-3.5	-1.5	0.5	1.5
Epididymis fat weight	8.8	20.6	35.3	4.7	4.5	5.5	5.7	3.2	5.9	4.1	1.0	-4.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.2	-0.0	0.0	-0.4	0.1	0.5	0.4	0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	0.2	0.2	0.2	0.3	0.3	0.2	0.1	-0.4
Diff in mean of infusions in LGA sessions	2.0	2.2	5.4	1.7	1.6	1.0	0.8	2.3	0.2	-1.5	-1.7	1.3
Delay discount exponential model param	1.0	1.0	2.9	-0.2	0.1	-0.4	-0.6	0.4	-0.9	-1.7	-1.5	1.5
Extinction: sum of active levers before priming	0.5	0.5	1.0	0.8	0.8	0.6	0.6	1.0	0.4	-0.4	-1.0	0.4
Active lever presses in extinction session 6	0.6	0.6	1.0	0.9	0.9	1.0	0.9	0.9	0.8	0.1	-0.6	-0.4
Bone: final force	3.1	4.9	13.1	-0.1	-0.3	0.8	1.1	-1.3	2.1	3.6	3.3	-3.5
Bone: final moment	2.7	4.4	11.7	-0.2	-0.4	0.7	0.9	-1.4	1.9	3.4	3.2	-3.3
Food consumed during 24 hour testing period	1.4	1.6	3.0	-1.6	-1.7	-1.4	-1.4	-1.7	-1.0	0.3	1.1	-0.3
Glucose	6.0	9.0	15.1	-3.3	-3.1	-3.7	-3.7	-2.4	-3.9	-2.5	-0.6	2.4
Heart weight	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	-0.5	-0.1	0.3	0.3	-0.2
Delay discount hyperbolic model param	0.9	1.0	2.8	0.1	0.4	-0.2	-0.3	0.7	-0.7	-1.7	-1.6	1.4
Intermittent access intake day 1-15 change	0.5	0.5	2.6	-0.1	-0.4	-0.1	0.0	-0.5	0.3	1.0	1.6	-0.8
Intermittent access intake escalation	0.6	0.6	1.7	-0.7	-1.0	-0.8	-0.7	-0.9	-0.6	0.3	1.3	-0.1
Intermittent access intake escalation 2	3.2	3.1	4.9	-2.0	-2.1	-2.2	-2.2	-1.8	-2.2	-0.9	0.8	0.8
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.1	-1.1	-1.1	-1.0	-1.0	-1.0	-0.8	-0.1	0.3	0.0
Intermitt. access day 15 inactive lever presses	0.9	1.0	3.0	-0.6	-0.6	-0.0	0.1	-0.9	0.7	1.6	1.2	-1.7
Intermitt. access escalation Index	1.3	1.1	3.1	0.6	0.7	0.1	-0.0	1.0	-0.6	-1.8	-1.7	1.4
Intermittent access day 1 total infusions	0.3	0.4	1.2	0.8	0.8	0.5	0.5	1.1	0.4	-0.3	-0.6	0.1
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.6	0.3	0.3	0.4	0.6	0.3	0.2	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	0.3	0.2	0.2	0.3	0.3	0.4	0.5	0.7	-0.6
Intermittent access total infusions	0.2	0.2	0.3	0.6	0.4	0.4	0.5	0.5	0.5	0.2	0.2	-0.3
Intermittent access day 1 locomotion	0.2	0.2	0.5	-0.3	-0.4	-0.7	-0.5	0.0	-0.7	-0.3	0.2	0.1
Intermittent access day 15 total locomotion	1.3	1.4	2.5	-1.3	-1.5	-1.3	-1.2	-1.4	-0.8	0.5	1.6	-0.5
Intermittent access total locomotion	1.0	1.1	2.2	-1.1	-1.3	-1.2	-1.0	-1.2	-0.7	0.4	1.5	-0.5
Intermittent access standard deviation	1.5	1.6	3.9	0.3	-0.0	0.6	0.8	-0.5	1.3	1.9	2.0	-1.9
Left kidney weight	1.9	5.4	13.9	-1.6	-1.7	-0.6	-0.3	-2.8	0.8	3.1	3.7	-3.2
Right kidney weight	2.1	6.0	12.4	-2.5	-2.6	-1.6	-1.4	-3.4	-0.3	2.3	3.5	-2.6
Cocaine induced anxiety	2.1	2.5	5.4	-0.9	-0.7	-1.4	-1.6	-0.1	-2.0	-2.3	-1.6	2.1
Post-drug Anxiety	1.1	1.2	2.3	-0.8	-0.5	-0.9	-1.0	-0.3	-1.3	-1.5	-1.3	1.4
Baseline Anxiety	0.8	0.8	1.5	1.1	1.0	1.2	1.2	0.6	1.2	0.6	-0.3	-0.5
Tail length	5.0	15.0	27.7	-4.8	-5.0	-4.0	-3.7	-5.3	-2.3	1.9	4.3	-1.8
Length with tail	3.6	13.2	25.1	-4.2	-4.4	-3.3	-3.0	-5.0	-1.5	2.6	4.6	-2.5
Length without tail	2.0	4.4	8.7	-2.2	-2.3	-1.5	-1.3	-2.9	-0.3	2.1	3.0	-2.2
Times rat made contact with spout	2.3	2.6	4.5	2.1	2.1	1.8	1.8	2.1	1.4	-0.2	-1.4	0.3
Lifetime Intake	0.1	0.1	0.2	0.4	0.3	0.3	0.4	0.4	0.4	0.2	0.2	-0.3
Liver weight, left	1.5	2.4	4.1	-2.0	-2.0	-1.9	-1.8	-1.9	-1.4	0.1	1.0	-0.2
Liver weight, right	4.9	8.2	15.1	-3.6	-3.7	-3.2	-3.0	-3.9	-2.2	0.7	2.6	-0.7
Locomotor activity	3.4	5.5	9.2	-3.0	-3.0	-2.8	-2.7	-2.9	-2.2	-0.1	1.6	0.0
Locomotor testing distance	0.6	1.0	1.9	-1.4	-1.3	-1.2	-1.2	-1.2	-1.0	-0.2	0.6	0.1
Locomotor testing rearing	1.1	1.7	3.0	-1.7	-1.7	-1.5	-1.5	-1.7	-1.1	0.1	1.0	-0.3
Locomotion in novel chamber	0.3	0.4	1.2	-0.3	-0.5	-0.3	-0.1	-0.5	0.1	0.8	1.1	-1.0
Locomotion in novel chamber post-restriction	0.3	0.3	0.9	0.2	0.1	0.4	0.5	-0.3	0.6	0.9	0.8	-0.7
Fecal boli incidents, locomotor time 1	0.4	0.4	1.3	0.2	0.5	0.1	0.0	0.6	-0.3	-1.0	-1.1	1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	-0.4	-0.6	-0.3	-0.3	-0.6	-0.0	0.7	1.0	-0.5
Time >=10cm from walls, locomotor time 1	1.5	1.5	2.8	-1.7	-1.5	-1.4	-1.4	-1.6	-1.1	-0.0	0.5	0.1
Bouts of movement, locomotor time 1	0.9	1.0	2.2	-0.5	-0.5	-0.9	-1.0	-0.1	-1.3	-1.5	-0.9	1.3
Total resting periods, locomotor time 1	0.8	0.9	1.7	-0.7	-0.8	-1.1	-1.1	-0.3	-1.3	-1.2	-0.5	0.9
Rest time, locomotor task time 1	1.5	1.7	2.8	-1.5	-1.5	-1.7	-1.7	-1.2	-1.5	-0.7	0.3	0.7
Distance moved, locomotor task time 1	0.6	0.6	1.1	0.5	0.5	0.9	0.9	0.1	1.0	1.0	0.4	-1.1
Vertical activity count, locomotor time 1	0.5	0.5	0.9	0.5	0.6	0.8	0.8	0.2	0.9	0.7	0.3	-0.9
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.2	-1.0	-0.9	-0.9	-0.9	-1.1	-0.9	-0.2	0.5	0.2
Bouts of movement, locomotor time 2	2.4	2.6	4.0	-1.9	-2.0	-1.9	-1.8	-1.9	-1.6	0.1	1.6	0.0
Total resting periods, locomotor time 2	3.1	3.3	5.2	-2.2	-2.3	-2.3	-2.2	-2.0	-2.0	-0.4	1.3	0.4
Rest time, locomotor task time 2	4.4	5.0	8.1	-2.5	-2.5	-2.8	-2.8	-2.0	-2.8	-1.6	0.2	1.5
Distance moved, locomotor task time 2	1.8	2.1	3.8	1.4	1.4	1.8	1.8	0.8	2.0	1.4	0.4	-1.5
Vertical activity count, locomotor time 2	0.9	0.9	1.5	1.2	1.1	1.2	1.2	0.9	1.2	0.5	0.0	-0.6
Light reinforcement 1	0.5	0.9	1.9	1.0	0.9	1.2	1.1	0.8	1.4	0.7	0.3	-0.6
Light reinforcement 2	0.5	0.7	1.3	-0.9	-1.1	-0.8	-0.7	-1.1	-0.5	0.5	1.2	-0.5
Bone: marrow area	5.2	11.3	19.2	-4.3	-4.4	-4.0	-3.9	-4.3	-3.0	0.2	2.5	-0.1
Bone: maximum diameter	2.3	4.2	6.8	-2.6	-2.6	-2.5	-2.4	-2.6	-2.1	-0.2	1.1	0.3
Bone: maximum force	2.4	4.2	11.0	-0.5	-0.7	0.4	0.7	-1.6	1.7	3.3	3.2	-3.2
Bone: maximum moment	2.2	3.8	9.9	-0.6	-0.9	0.2	0.4	-1.6	1.4	3.1	3.1	-3.0
Mean time between licks in bursts	3.3	4.7	7.6	-2.5	-2.4	-2.7	-2.8	-2.0	-2.6	-1.5	-0.0	1.5
Mean num. licks in bursts	2.0	2.4	4.0	1.9	1.8	1.9	1.9	1.6	2.0	0.9	-0.2	-0.7
Cd content in liver	0.8	0.9	1.5	0.8	0.7	1.0	1.1	0.4	1.2	1.2	0.6	-1.1
Co content in liver	1.7	1.9	3.5	1.0	1.0	1.5	1.6	0.3	1.9	1.8	0.9	-1.8
Cu content in liver	3.7	4.5	8.2	2.6	2.7	2.2	2.0	2.9	1.3	-1.0	-2.3	1.1
Fe content in liver	0.8	0.9	1.5	0.8	0.7	1.0	1.1	0.5	1.2	1.2	0.8	-1.1
K content in liver	0.1	0.1	0.5	0.2	0.2	0.1	0.0	0.2	-0.1	-0.4	-0.7	0.3
Mg content in liver	2.3	2.4	4.7	-0.9	-0.8	-1.5	-1.6	-0.4	-2.0	-2.2	-1.6	2.1
Mn content in liver	5.4	6.2	10.4	-2.6	-2.4	-3.0	-3.1	-1.7	-3.2	-2.4	-0.8	2.3
Na content in liver	0.2	0.2	0.4	0.4	0.4	0.5	0.6	0.2	0.6	0.5	0.1	-0.4
Rb content in liver	0.5	0.6	1.8	0.6	0.6	0.3	0.2	0.9	-0.3	-1.1	-1.3	1.0
Se content in liver	3.7	4.6	8.1	-2.2	-2.1	-2.6	-2.7	-1.6	-2.8	-1.8	-0.5	2.0
Sr content in liver	1.0	0.9	1.6	-1.3	-1.2	-1.1	-1.0	-1.1	-0.7	0.3	0.9	-0.3
Zn content in liver	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.3	-0.3	-0.3	-0.3	-0.1	0.2
Bone: minimum diameter	2.9	5.4	8.8	-2.9	-3.0	-2.9	-2.8	-2.8	-2.3	-0.3	1.3	0.4
Time in familiar zone, hab. session 1	3.8	3.6	6.6	2.4	2.5	2.0	1.9	2.6	1.2	-0.6	-1.9	0.7
Time in novel zone, hab. session 1	2.7	2.6	4.5	-2.1	-2.1	-1.8	-1.8	-2.1	-1.3	0.2	1.4	-0.3
Total zone transitions, hab. session 1	0.3	0.5	1.2	0.6	0.7	0.3	0.3	0.8	-0.1	-0.9	-1.1	0.7
Total locomotion distance, hab. session 1	0.3	0.5	0.9	0.8	0.8	0.5	0.5	1.0	0.2	-0.6	-0.9	0.5
Locomotion velocity, hab. session 1	0.3	0.5	0.8	0.9	0.9	0.7	0.7	0.9	0.5	-0.2	-0.6	0.1
Time in familiar zone, hab. session 2	0.5	0.5	0.9	0.8	0.9	0.8	0.8	0.8	0.6	-0.2	-0.9	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.9	-0.5	-0.5	-0.3	-0.3	-0.5	-0.1	0.4	0.9	-0.5
Total zone transitions, hab. session 2	0.2	0.3	0.5	0.6	0.6	0.6	0.7	0.5	0.6	0.3	-0.0	-0.3
Total locomotion distance, hab. session 2	0.6	0.8	1.7	1.1	1.1	0.7	0.7	1.3	0.3	-0.8	-1.1	0.8
Locomotion velocity, hab. session 2	0.6	0.8	1.7	1.0	1.1	0.6	0.6	1.3	0.2	-0.9	-1.2	0.9
Novel to familiar place preference ratio	0.2	0.2	0.4	0.5	0.5	0.6	0.6	0.5	0.6	0.3	-0.0	-0.3
Novelty place preference	0.1	0.1	0.2	0.3	0.2	0.4	0.4	0.2	0.5	0.4	0.2	-0.5
Time in novel zone, NPP test	0.1	0.1	0.3	0.1	0.0	0.2	0.2	-0.0	0.4	0.5	0.4	-0.5
Total zone transitions, NPP test	0.5	0.7	1.4	0.6	0.7	0.3	0.2	1.0	-0.2	-1.2	-1.2	1.1
Total locomotion distance, NPP test	0.8	1.1	2.3	1.3	1.3	0.9	0.9	1.5	0.4	-0.8	-1.2	0.8
Locomotion velocity, NPP test	1.3	1.8	3.6	1.5	1.6	1.1	1.0	1.9	0.4	-1.1	-1.6	1.1
Intraocular pressure	0.4	0.6	1.5	0.6	0.6	0.3	0.1	0.8	-0.2	-1.0	-1.2	1.2
Delta distance traveled before/after self-admin	0.4	0.5	1.2	-0.4	-0.4	-0.1	0.0	-0.6	0.4	1.0	1.0	-1.1
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	-0.7	-0.7	-0.6	-0.5	-0.7	-0.3	0.4	0.8	-0.5
Parametrial fat weight	1.0	2.0	5.4	-0.3	-0.4	0.3	0.5	-1.1	1.2	2.3	2.3	-2.1
Pavlov. Cond. lever latency	3.1	3.9	7.0	2.0	1.9	2.3	2.4	1.3	2.6	1.9	0.9	-1.8
Pavlov. Cond. magazine entry latency	3.0	3.8	6.8	-1.9	-1.8	-2.3	-2.4	-1.2	-2.6	-2.1	-0.8	2.0
Pavlov. Cond. change in total contacts	2.2	2.3	3.8	-2.0	-1.9	-1.9	-1.8	-1.8	-1.6	-0.2	0.7	0.2
Pavlov. Cond. index score	4.0	5.0	8.9	-2.2	-2.1	-2.6	-2.7	-1.4	-3.0	-2.2	-0.9	2.1
Pavlov. Cond. latency score	3.8	4.8	8.2	-2.3	-2.2	-2.7	-2.7	-1.6	-2.9	-2.0	-0.6	1.8
Pavlov. Cond. lever contacts	3.1	3.7	6.2	-2.2	-2.0	-2.4	-2.4	-1.6	-2.5	-1.5	-0.4	1.4
Pavlov. Cond. magazine entry number	2.2	2.7	5.0	1.2	1.1	1.7	1.8	0.5	2.2	2.1	1.2	-2.1
Pavlov. Cond. intertrial magazine entries	2.1	2.5	4.1	2.0	2.0	1.9	1.9	1.8	1.7	0.5	-0.7	-0.2
Pavlov. Cond. lever-magazine prob. diff.	3.8	4.8	8.7	-2.1	-2.0	-2.5	-2.6	-1.3	-2.9	-2.3	-1.0	2.2
Pavlov. Cond. response bias	3.5	4.3	7.9	-1.9	-1.7	-2.4	-2.4	-1.1	-2.8	-2.3	-1.1	2.2
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.5	-0.6	-0.4	-0.4	-0.6	-0.2	0.6	0.8	-0.3
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	-0.9	-0.9	-0.6	-0.6	-1.0	-0.3	0.3	0.7	-0.5
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.4	0.4	0.6	0.6	0.1	0.8	0.5	0.2	-0.7
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0	-0.1	0.0	-0.2	-0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.0	0.1	0.1	-0.1	0.2	0.1	0.0	-0.3
Pavlov. Cond. lever contacts	0.5	0.7	1.1	1.0	1.1	1.0	1.0	0.9	0.8	-0.1	-0.6	-0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.3	0.3	0.1	0.0	0.5	-0.2	-0.5	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	1.6	2.1	4.0	-1.0	-1.0	-1.6	-1.7	-0.4	-1.9	-1.7	-0.9	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0	-0.1	0.0	-0.2	-0.2	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.4	0.4	0.4	0.3	0.4	0.2	-0.3	-0.5	0.1
Time in closed arm before self-admin	0.0	0.0	0.1	0.1	0.2	0.2	0.1	0.1	0.0	-0.1	-0.3	0.2
Time in closed arm after self-admin	0.6	0.6	1.4	0.5	0.5	0.8	0.9	0.1	1.1	1.2	0.6	-1.0
Time in open arm before self-admin	0.6	0.7	1.3	-0.9	-0.9	-1.1	-1.1	-0.4	-1.1	-0.8	-0.2	0.2
Time in open arm after self-admin	0.5	0.5	1.2	-0.5	-0.4	-0.8	-0.8	0.2	-1.0	-1.1	-0.7	0.5
Bone: periosteal estimation	3.0	6.2	12.0	-3.0	-3.1	-2.5	-2.3	-3.5	-1.5	1.3	2.8	-1.2
Bone: periosteal perimeter	2.2	3.7	6.6	-2.4	-2.5	-2.2	-2.1	-2.6	-1.6	0.4	1.6	-0.3
Bone: post-yield work	1.7	2.3	3.8	-1.8	-1.8	-1.9	-1.9	-1.4	-1.8	-0.9	0.1	1.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	0.5	0.4	0.2	0.3	0.7	0.1	0.0	0.1	-0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	0.5	0.5	0.3	0.4	0.8	0.2	0.1	0.0	-0.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.5	1.2	1.1	1.2	1.2	1.1	1.1	0.4	-0.3	-0.5
Progressive ratio test 2 active lever presses	0.4	0.5	1.2	1.0	0.8	0.6	0.6	1.1	0.3	-0.3	-0.3	0.6
Progressive ratio test 2 breakpoint	0.7	0.8	1.8	1.2	1.1	0.7	0.7	1.4	0.4	-0.6	-0.6	0.9
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.6	-0.5	-0.5	-0.4	-0.3	-0.4	-0.0	0.6	0.8	-0.6
Incentive Sensitization - Responses	0.3	0.3	0.8	0.8	0.6	0.4	0.3	0.8	0.1	-0.4	-0.4	0.9
Incentive Sensitization - Breakpoint	0.4	0.4	1.1	0.7	0.6	0.3	0.2	0.8	0.0	-0.6	-0.5	1.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	0.6	0.5	0.3	0.3	0.8	0.1	-0.5	-0.7	0.6
Progressive ratio	2.4	2.8	8.0	-0.4	-0.7	0.2	0.4	-1.5	1.1	2.8	2.8	-2.3
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.0	0.1	0.0	0.0	-0.0	0.1	-0.1	-0.2	-0.2
Seeking ratio, punishment vs. effort	2.1	2.5	7.6	0.4	0.7	-0.1	-0.3	1.3	-0.9	-2.7	-2.7	2.1
Retroperitoneal fat weight	0.2	0.7	2.1	-0.2	-0.2	0.2	0.3	-0.5	0.7	1.3	1.2	-1.5
Reaction time number correct	1.3	1.9	3.5	1.6	1.5	1.7	1.7	1.2	1.9	0.9	-0.0	-0.9
Reaction time mean minus median	5.4	7.2	11.8	-3.1	-3.1	-3.4	-3.4	-2.5	-3.3	-1.7	0.3	1.4
Reaction time mean minus median AUC	3.6	4.7	7.8	-2.4	-2.4	-2.8	-2.8	-1.8	-2.8	-1.6	0.0	1.4
Reaction time num false alarms	0.2	0.3	0.6	-0.7	-0.7	-0.5	-0.4	-0.8	-0.1	0.4	0.7	-0.4
Reaction time num false alarms AUC	0.4	0.5	0.9	-0.8	-0.8	-0.5	-0.5	-0.9	-0.1	0.6	0.9	-0.7
Reaction time trials correct on left	1.3	1.9	3.5	1.6	1.5	1.7	1.7	1.2	1.9	0.9	-0.0	-0.9
Reaction time trials on left	1.2	1.7	3.1	1.5	1.4	1.6	1.6	1.1	1.8	0.8	0.0	-0.9
Reaction time mean	4.2	5.8	10.1	-2.7	-2.6	-3.0	-3.0	-1.9	-3.2	-1.9	-0.3	1.7
Reaction time mean AUC	4.4	6.0	10.3	-2.7	-2.6	-3.1	-3.1	-2.0	-3.2	-1.9	-0.2	1.7
Median of all reaction times	2.5	3.4	6.3	-2.0	-1.9	-2.3	-2.3	-1.4	-2.5	-1.5	-0.4	1.5
Reaction time omissions	3.2	4.3	7.0	-2.3	-2.3	-2.6	-2.6	-1.8	-2.6	-1.4	-0.1	1.6
Reaction time false alarm rate	1.0	1.4	2.5	-1.6	-1.6	-1.4	-1.4	-1.5	-1.2	-0.1	0.8	-0.1
Reaction time premature initiation rate	0.6	0.8	2.3	-0.2	-0.3	0.2	0.3	-0.7	0.7	1.4	1.5	-1.2
Reaction time premature initiations	1.2	1.7	3.7	0.6	0.5	1.1	1.2	-0.1	1.7	1.9	1.6	-1.7
Std. dev. reaction times	5.4	7.6	12.5	-3.3	-3.2	-3.5	-3.5	-2.6	-3.4	-1.6	0.4	1.4
Reaction time trials completed	1.2	1.7	3.1	1.5	1.4	1.6	1.6	1.1	1.8	0.8	0.0	-0.9
Reaction time trials AUC	1.2	1.7	3.2	1.5	1.4	1.6	1.6	1.2	1.8	0.8	-0.1	-0.8
Run reversals in cocaine runway, females	1.2	1.2	2.3	1.1	1.2	1.3	1.4	0.9	1.5	0.7	-0.2	-0.9
Run reversals in cocaine runway, males	3.7	3.6	6.4	-2.5	-2.4	-2.3	-2.3	-2.3	-1.8	-0.4	1.1	-0.1
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.0	0.0	0.1	0.1	0.1	0.1	0.3	0.1	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	-0.1	0.1	-0.1	-0.2	0.3	-0.4	-0.5	-0.7	0.4
Latency to leave start box in cocaine runway, M	0.9	0.8	2.0	0.3	0.2	0.7	0.8	-0.2	1.2	1.3	1.0	-1.4
Std. dev. time between licks in bursts	3.5	4.2	6.8	-2.5	-2.4	-2.6	-2.6	-2.1	-2.4	-1.3	0.1	1.0
Total sessions with >9 infusions	0.0	0.0	0.2	0.1	0.0	0.0	0.1	0.1	0.1	0.4	0.3	-0.4
Short access day 1 total inactive lever presses	1.8	2.0	3.4	-1.7	-1.8	-1.8	-1.8	-1.4	-1.6	-0.5	0.5	0.3
Short access day 10 total inactive lever presses	0.4	0.5	0.8	-0.8	-0.8	-0.9	-0.9	-0.8	-0.8	-0.4	-0.0	0.2
Short access day 1 total infusions	0.1	0.1	0.3	0.2	0.2	-0.1	-0.0	0.5	-0.2	-0.5	-0.5	0.2
Short access day 10 total infusions	0.1	0.1	0.2	0.1	0.1	0.2	0.2	0.1	0.4	0.3	0.3	-0.3
Short access total infusions	0.1	0.1	0.3	0.0	0.1	0.1	0.2	0.1	0.3	0.3	0.3	-0.6
Short access day 1 locomotion	1.4	1.5	3.7	0.6	0.7	-0.0	-0.1	1.2	-0.8	-1.8	-1.9	1.9
Short access day 10 total locomotion	1.4	1.6	2.5	-1.6	-1.5	-1.6	-1.5	-1.4	-1.4	-0.6	0.3	0.5
Short access total locomotion	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.6	-0.2	-0.6	-0.5	-0.3	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.6	0.3	0.3	-0.1	-0.0	0.7	-0.3	-0.8	-0.6	0.4
Compulsive drug intake	1.5	1.5	4.0	0.3	0.5	-0.2	-0.3	0.9	-1.0	-2.0	-2.0	1.8
One hour access (shock baseline)	0.4	0.5	1.1	-0.7	-0.8	-0.6	-0.5	-0.7	-0.1	0.6	1.1	-0.8
Social response proportion	0.5	0.6	1.0	-1.0	-0.9	-1.0	-0.9	-0.7	-0.8	-0.3	0.3	-0.0
Social responses	0.1	0.1	0.3	-0.4	-0.4	-0.3	-0.2	-0.3	-0.2	0.2	0.5	-0.5
Social time	3.8	5.0	8.1	-2.7	-2.6	-2.8	-2.8	-2.2	-2.8	-1.1	0.6	0.9
Soleus weight	3.4	9.9	15.6	-3.9	-3.9	-4.0	-3.9	-3.5	-3.5	-1.0	1.1	1.0
Bone: stiffness	0.8	1.2	3.1	0.3	0.2	0.7	0.9	-0.3	1.3	1.7	1.4	-1.7
Tibialis anterior weight	0.5	1.8	3.0	1.5	1.5	1.7	1.7	1.2	1.6	0.6	-0.1	-0.8
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.5	-0.5	-0.7	-0.7	-0.4	-0.8	-0.5	-0.1	0.7
Time to tail flick, vehicle, after self-admin	1.6	1.7	3.1	-1.1	-1.0	-1.4	-1.5	-0.6	-1.7	-1.5	-0.7	1.7
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.6	0.5	0.6	0.5	0.2	0.6	0.5	0.1	-0.3
Time to tail flick, test, after self-admin	1.0	1.0	2.0	-0.6	-0.8	-1.2	-1.2	-0.3	-1.4	-1.2	-0.4	1.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.3	0.1	0.2	-0.1	-0.2	0.3	-0.5	-0.9	-0.8	1.2
Delta time to tail flick, test, before/after SA	0.4	0.4	1.2	0.2	0.2	-0.2	-0.2	0.5	-0.5	-1.0	-0.7	1.1
Tibia length	2.9	8.1	15.5	-3.5	-3.6	-2.9	-2.7	-3.9	-1.8	1.4	3.1	-1.2
Ambulatory time before self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.2	-0.4	-0.2	-0.1	-0.3
Ambulatory time after self-admin	0.6	0.6	1.3	-1.1	-1.0	-0.9	-1.0	-1.0	-0.8	-0.2	0.0	0.2
Bone: tissue strength	2.1	2.0	5.1	-0.2	-0.4	0.4	0.5	-0.9	1.3	2.3	2.2	-2.2
Total heroin consumption	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.2	-0.1	-0.3	-0.1	-0.3
Bone: trabecular number	1.5	2.3	4.8	1.9	1.9	1.5	1.4	2.2	0.9	-0.6	-1.6	0.8
Bone: trabecular spacing	2.3	2.9	6.1	-1.9	-1.9	-1.2	-1.1	-2.5	-0.3	1.4	2.3	-1.7
Bone: trabecular thickness	0.9	1.1	2.4	1.3	1.3	1.0	0.9	1.5	0.5	-0.5	-1.2	0.7
Bone: trabecular tissue density	0.8	1.2	2.9	-0.4	-0.5	0.1	0.2	-1.0	0.7	1.7	1.7	-1.6
Water consumed over 24 hours	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.4	-0.6	-0.2	-0.0	0.2
Number of responses in last shaping day	0.2	0.2	0.5	-0.5	-0.6	-0.5	-0.4	-0.5	-0.2	0.4	0.7	-0.1