LOC103694952

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative polyA XR_001842083.2 0.11 0.06 4.5e-11 0.1 0.08 0.09 0.1 3.3e-11 1.1e-09 8.9e-11 2.6e-11
2 Brain gene expression LOC103694952 0.03 0.02 1.4e-03 0 0.03 0.01 0.01 1.3e-01 2.0e-03 3.6e-02 5.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.90.9-0.7
Area under the delay curve3.73.94.81.8-2.2
BMI with tail6.420.722.4-4.44.7
BMI without tail5.110.410.6-3.23.3
Body weight6.225.828.1-4.85.3
Weight adjusted by age1.82.12.3-1.51.3
Bone surface1.12.02.81.7-1.1
Bone volume0.81.32.01.4-0.8
Breakpoint value in progressive ratio session0.00.10.1-0.30.2
Number of licking bursts1.72.02.51.6-1.2
Context. condit. distance diff. score0.00.00.00.1-0.1
Locomotion velocity, session 10.60.70.9-0.70.9
Locomotion distance, session 10.00.00.0-0.00.2
Locomotion velocity, session 20.60.70.9-0.70.9
Locomotion distance, session 20.60.91.11.0-0.8
Locomotion velocity, session 30.30.30.4-0.50.7
Locomotion distance, session 30.10.10.20.4-0.3
Stereotopy head waving bouts, day 32.22.62.61.6-1.6
Stereotopy head waving duration, day 30.00.00.1-0.0-0.2
Locomotion velocity, session 70.10.10.1-0.20.3
Locomotion distance, session 70.40.50.50.7-0.7
Stereotopy head waving bouts, day 70.80.91.2-1.10.7
Stereotopy head waving duration, day 70.20.30.4-0.60.4
Locomotion velocity, session 80.40.50.7-0.80.6
Locomotion distance, session 80.00.00.00.2-0.1
Degree of sensitization distance0.00.00.0-0.20.1
Degree of sensitization stereotypy0.40.50.7-0.80.5
Conditioned locomotion0.00.00.10.3-0.1
Cocaine response after cond. corrected0.70.80.9-0.81.0
Cocaine response after cond. not corrected0.00.00.00.00.1
Cocaine response before conditioning5.56.66.72.6-2.6
Saline control response0.91.21.31.1-1.1
Bone: connectivity density1.82.83.11.8-1.6
Bone: cortical apparent density0.91.21.31.0-1.2
Bone: cortical area3.85.76.42.5-2.2
Bone: cortical porosity1.01.11.1-1.01.1
Bone: cortical porosity0.70.80.8-0.90.9
Bone: cortical thickness3.04.95.12.3-2.1
Bone: cortical thickness0.60.60.70.9-0.7
Bone: cortical tissue density0.70.91.00.9-1.0
Condit. Reinf. active minus inactive responses2.02.22.31.4-1.5
Condit. Reinf. active-inactive response ratio1.31.41.61.1-1.3
Condit. Reinf. active responses2.02.42.91.7-1.4
Condit. Reinf. inactive responses1.31.52.21.5-0.9
Incentive salience index mean1.51.81.91.3-1.4
Condit. Reinf. lever presses1.01.31.41.1-1.2
Condit. Reinf. active minus inactive responses2.93.53.61.9-1.9
Condit. Reinf. active-inactive response ratio0.10.10.1-0.40.2
Condit. Reinf. active responses7.911.011.23.3-3.3
Condit. Reinf. inactive responses9.611.811.93.5-3.4
Condit. Reinf. lever presses2.43.33.61.9-1.7
Condit. Reinf. lever reinforcers received7.19.910.23.1-3.2
Conditioned reinforcement - actives0.10.10.2-0.40.1
Conditioned reinforcement - inactives0.10.10.10.4-0.3
Conditioned locomotion0.00.00.10.2-0.2
Patch foraging indifference point 0 sec2.43.84.11.9-2.0
Patch foraging indifference point AUC3.54.04.31.9-2.1
Delay disc. indifference point, 0s delay1.51.61.91.2-1.4
Delay disc. indifference point, 16s delay5.15.15.82.1-2.4
Delay disc. indifference point, 2s delay0.40.40.70.4-0.8
Delay disc. indifference point, 24s delay0.50.50.70.5-0.8
Delay disc. indifference point, 4s delay0.50.60.80.6-0.9
Delay disc. indifference point, 8s delay4.95.16.02.0-2.4
Indifference point function ln k8.111.311.9-3.33.5
Indifference point function log k8.111.311.9-3.33.5
Patch foraging total patch changes 0 sec2.43.94.01.9-2.0
Patch foraging total patch changes 12 sec11.014.214.53.8-3.7
Patch foraging total patch changes 18 sec5.77.37.32.7-2.7
Patch foraging total patch changes 24 sec4.15.05.22.3-2.2
Patch foraging total patch changes 6 sec4.76.97.02.6-2.6
Patch foraging time to switch 0 sec0.10.20.2-0.40.5
Patch foraging water rate 0 sec0.00.00.00.1-0.1
Patch foraging water rate 12 sec0.20.30.5-0.40.7
Patch foraging water rate 18 sec0.20.30.3-0.50.5
Patch foraging water rate 24 sec0.20.20.4-0.30.6
Patch foraging water rate 6 sec0.00.00.1-0.00.3
Seeking ratio, delayed vs. immediate footshock0.40.50.50.7-0.7
Distance traveled before self-admin0.10.10.2-0.5-0.2
Distance traveled after self-admin0.30.40.40.5-0.7
Extensor digitorum longus weight2.07.77.8-2.82.8
Bone: elastic displacement1.71.92.1-1.41.3
Bone: elastic work2.12.72.9-1.71.6
Bone: endosteal estimation0.71.52.11.4-1.0
Bone: endosteal perimeter0.10.30.40.6-0.4
Epididymis fat weight5.212.212.2-3.53.5
Delta time in closed arm before/after self-admin4.44.34.8-2.22.0
Delta time in open arm before/after self-admin1.51.51.71.3-1.1
Diff in mean of infusions in LGA sessions1.01.11.3-1.01.2
Delay discount exponential model param3.94.14.9-1.82.2
Extinction: sum of active levers before priming0.20.20.2-0.40.3
Active lever presses in extinction session 62.72.63.11.8-1.5
Bone: final force1.52.42.61.6-1.5
Bone: final moment0.81.41.51.2-1.1
Food consumed during 24 hour testing period0.81.01.2-0.91.1
Glucose7.811.711.8-3.43.4
Heart weight2.33.23.7-1.61.9
Delay discount hyperbolic model param3.53.74.5-1.72.1
Intermittent access intake day 1-15 change0.20.20.3-0.30.5
Intermittent access intake escalation0.00.00.10.00.2
Intermittent access intake escalation 20.10.10.1-0.20.4
Intermitt. access day 1 inactive lever presses0.10.10.10.30.1
Intermitt. access day 15 inactive lever presses0.00.00.00.20.2
Intermitt. access escalation Index1.11.01.3-0.81.2
Intermittent access day 1 total infusions0.10.20.20.4-0.4
Intermittent access day 15 total infusions0.10.20.30.5-0.2
Intermittent access terminal intake (last 3 days)0.10.10.10.4-0.2
Intermittent access total infusions0.00.00.0-0.10.2
Intermittent access day 1 locomotion0.00.00.0-0.10.2
Intermittent access day 15 total locomotion2.02.12.8-1.21.7
Intermittent access total locomotion1.21.31.5-1.11.2
Intermittent access standard deviation0.10.10.1-0.30.3
Left kidney weight0.10.30.4-0.50.6
Right kidney weight0.00.10.2-0.10.4
Cocaine induced anxiety0.20.20.2-0.40.5
Post-drug Anxiety0.40.40.60.7-0.5
Baseline Anxiety0.80.91.01.0-0.9
Tail length0.10.20.2-0.40.5
Length with tail0.62.32.3-1.51.5
Length without tail0.61.31.3-1.11.2
Times rat made contact with spout0.00.00.00.20.2
Lifetime Intake0.10.10.2-0.40.3
Liver weight, left0.00.00.0-0.10.2
Liver weight, right0.91.51.61.3-1.1
Locomotor activity0.10.10.10.3-0.4
Locomotor testing distance0.00.00.00.1-0.2
Locomotor testing rearing0.71.11.21.1-1.0
Locomotion in novel chamber0.10.10.1-0.40.3
Locomotion in novel chamber post-restriction0.00.00.00.1-0.0
Fecal boli incidents, locomotor time 10.20.20.2-0.50.3
Change in fecal boli incidents, locomotor task0.20.20.2-0.50.4
Time >=10cm from walls, locomotor time 10.50.50.6-0.60.8
Bouts of movement, locomotor time 11.61.72.11.5-1.2
Total resting periods, locomotor time 11.21.31.51.2-1.0
Rest time, locomotor task time 10.00.00.10.10.3
Distance moved, locomotor task time 10.10.10.10.2-0.3
Vertical activity count, locomotor time 10.20.20.3-0.60.3
Time >=10cm from walls, locomotor time 25.15.45.6-2.42.3
Bouts of movement, locomotor time 20.30.30.40.5-0.6
Total resting periods, locomotor time 20.10.10.10.2-0.3
Rest time, locomotor task time 21.51.71.9-1.41.3
Distance moved, locomotor task time 20.40.40.40.6-0.6
Vertical activity count, locomotor time 20.40.40.50.6-0.7
Light reinforcement 11.93.43.61.9-1.8
Light reinforcement 23.24.34.81.9-2.2
Bone: marrow area0.71.52.11.4-1.0
Bone: maximum diameter3.15.76.52.6-2.2
Bone: maximum force0.50.91.11.0-0.9
Bone: maximum moment0.20.30.40.6-0.5
Mean time between licks in bursts0.10.10.30.10.5
Mean num. licks in bursts1.72.02.2-1.51.4
Cd content in liver0.00.00.00.0-0.0
Co content in liver0.30.30.4-0.50.6
Cu content in liver4.04.85.42.1-2.3
Fe content in liver1.92.22.31.5-1.5
K content in liver0.20.20.20.4-0.4
Mg content in liver1.31.31.41.2-1.1
Mn content in liver0.30.40.5-0.40.7
Na content in liver0.00.00.0-0.1-0.1
Rb content in liver2.43.03.82.0-1.5
Se content in liver0.50.60.70.8-0.7
Sr content in liver0.60.50.80.5-0.9
Zn content in liver2.52.82.91.6-1.7
Bone: minimum diameter1.12.12.61.6-1.3
Time in familiar zone, hab. session 10.10.10.1-0.30.3
Time in novel zone, hab. session 11.01.01.10.9-1.1
Total zone transitions, hab. session 12.33.33.5-1.71.9
Total locomotion distance, hab. session 10.10.10.1-0.30.4
Locomotion velocity, hab. session 10.10.20.2-0.40.5
Time in familiar zone, hab. session 24.34.54.72.2-2.1
Time in novel zone, hab. session 23.93.94.2-2.11.9
Total zone transitions, hab. session 20.10.10.2-0.20.4
Total locomotion distance, hab. session 20.30.40.50.7-0.4
Locomotion velocity, hab. session 20.10.10.20.4-0.1
Novel to familiar place preference ratio2.32.43.3-1.81.2
Novelty place preference2.92.93.9-2.01.4
Time in novel zone, NPP test2.42.43.3-1.81.3
Total zone transitions, NPP test0.00.00.00.20.2
Total locomotion distance, NPP test0.30.50.60.8-0.5
Locomotion velocity, NPP test0.50.70.90.9-0.7
Intraocular pressure4.15.66.3-2.22.5
Delta distance traveled before/after self-admin1.71.82.41.6-1.1
Delta ambulatory time before/after self-admin1.71.92.51.6-1.2
Parametrial fat weight1.42.73.6-1.91.4
Pavlov. Cond. lever latency0.00.00.10.1-0.3
Pavlov. Cond. magazine entry latency0.30.30.40.5-0.6
Pavlov. Cond. change in total contacts0.00.00.10.1-0.3
Pavlov. Cond. index score0.00.00.0-0.1-0.0
Pavlov. Cond. latency score0.10.10.1-0.30.2
Pavlov. Cond. lever contacts0.00.00.00.1-0.2
Pavlov. Cond. magazine entry number0.10.20.2-0.40.5
Pavlov. Cond. intertrial magazine entries0.20.20.40.6-0.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.2-0.2
Pavlov. Cond. response bias0.10.20.20.4-0.4
Pavlov. Cond. lever latency1.01.31.4-1.11.2
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.2
Pavlov. Cond. change in total contacts1.42.02.31.3-1.5
Pavlov. Cond. index score0.50.60.60.8-0.8
Pavlov. Cond. latency score0.40.50.60.6-0.7
Pavlov. Cond. lever contacts1.21.61.81.3-1.2
Pavlov. Cond. magazine entry number0.91.11.2-1.01.1
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.50.60.70.8-0.8
Pavlov. Cond. response bias2.12.82.91.7-1.6
Time in closed arm before self-admin0.30.40.5-0.50.7
Time in closed arm after self-admin1.61.61.9-1.41.2
Time in open arm before self-admin0.00.00.0-0.10.1
Time in open arm after self-admin0.80.91.41.2-0.6
Bone: periosteal estimation2.04.14.92.2-1.8
Bone: periosteal perimeter1.01.72.01.4-1.2
Bone: post-yield work0.20.20.30.5-0.5
Progressive ratio test 1 active lever presses0.20.20.2-0.40.4
Progressive ratio test 1 breakpoint0.20.20.2-0.50.4
Progressive ratio test 1 inactive lever presses0.00.10.10.3-0.2
Progressive ratio test 2 active lever presses0.40.40.5-0.60.7
Progressive ratio test 2 breakpoint0.60.70.8-0.80.9
Progressive ratio test 2 inactive lever presses0.10.10.3-0.20.5
Incentive Sensitization - Responses0.10.10.1-0.20.4
Incentive Sensitization - Breakpoint0.10.10.1-0.30.4
Sum of active levers in priming session hrs 5-62.02.02.31.3-1.5
Progressive ratio0.10.10.1-0.40.1
Food seeking constrained by brief footshock0.10.20.20.3-0.4
Seeking ratio, punishment vs. effort0.20.20.30.6-0.3
Retroperitoneal fat weight4.314.014.6-3.83.7
Reaction time number correct0.91.21.8-0.91.3
Reaction time mean minus median0.20.30.30.4-0.6
Reaction time mean minus median AUC0.00.00.0-0.20.0
Reaction time num false alarms1.52.12.8-1.71.2
Reaction time num false alarms AUC2.43.44.3-2.11.6
Reaction time trials correct on left0.91.21.8-0.91.3
Reaction time trials on left0.91.31.8-0.91.4
Reaction time mean0.70.91.3-1.10.8
Reaction time mean AUC0.40.60.9-0.90.5
Median of all reaction times1.52.12.7-1.61.2
Reaction time omissions0.00.00.00.1-0.1
Reaction time false alarm rate1.01.32.1-1.40.8
Reaction time premature initiation rate4.05.46.82.6-2.0
Reaction time premature initiations1.92.73.92.0-1.3
Std. dev. reaction times0.20.20.3-0.50.4
Reaction time trials completed0.91.31.8-0.91.4
Reaction time trials AUC0.91.31.8-0.91.3
Run reversals in cocaine runway, females0.40.40.50.5-0.7
Run reversals in cocaine runway, males0.00.00.0-0.2-0.1
Latency to leave start box in cocaine runway2.12.32.41.6-1.5
Latency to leave start box in cocaine runway, F2.22.42.91.7-1.4
Latency to leave start box in cocaine runway, M0.20.20.3-0.60.1
Std. dev. time between licks in bursts0.10.10.10.3-0.2
Total sessions with >9 infusions1.61.82.1-1.51.2
Short access day 1 total inactive lever presses0.10.10.10.3-0.3
Short access day 10 total inactive lever presses0.60.71.11.0-0.6
Short access day 1 total infusions0.70.81.2-1.10.6
Short access day 10 total infusions0.00.00.0-0.0-0.1
Short access total infusions0.10.10.1-0.40.0
Short access day 1 locomotion2.22.32.5-1.61.5
Short access day 10 total locomotion2.02.22.2-1.51.5
Short access total locomotion1.21.31.5-1.21.1
One hour access (0.3 mA shock)0.40.50.6-0.80.6
Compulsive drug intake0.90.91.2-1.10.8
One hour access (shock baseline)0.00.00.00.0-0.0
Social response proportion1.01.11.2-1.11.0
Social responses0.20.30.50.3-0.7
Social time0.30.40.5-0.70.5
Soleus weight2.05.96.7-2.62.3
Bone: stiffness1.11.82.01.4-1.2
Tibialis anterior weight0.72.53.1-1.41.8
Time to tail flick, vehicle, before self-admin3.03.13.71.6-1.9
Time to tail flick, vehicle, after self-admin0.20.20.20.4-0.4
Time to tail flick, test, before self-admin0.20.20.2-0.50.3
Time to tail flick, test, after self-admin0.50.60.70.6-0.8
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.40.9
Delta time to tail flick, test, before/after SA0.00.00.10.1-0.3
Tibia length0.72.02.2-1.41.5
Ambulatory time before self-admin0.10.10.2-0.4-0.1
Ambulatory time after self-admin0.30.40.50.5-0.7
Bone: tissue strength0.00.00.0-0.10.1
Total heroin consumption0.40.50.8-0.90.4
Bone: trabecular number0.30.40.70.8-0.5
Bone: trabecular spacing0.00.00.10.2-0.2
Bone: trabecular thickness0.40.50.60.8-0.6
Bone: trabecular tissue density0.00.10.1-0.30.2
Water consumed over 24 hours0.20.30.50.7-0.3
Number of responses in last shaping day0.80.91.21.1-0.7