Hub : Genes

LOC103692978

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC103692978	0.03	0.03	8.6e-04	0.01	0.01	0.01	0.01	7.3e-03	8.3e-03	4.3e-02	2.3e-02
2	PL	alternative polyA	XR_005487582.1	0.02	0.02	7.3e-03	0.01	0.01	0	0.01	7.4e-03	2.2e-02	1.5e-01	3.5e-02
3	PL	isoform ratio	XR_005487583.1	0.27	0.19	4.7e-04	0.03	0.01	0.02	0.03	6.7e-04	1.6e-02	4.1e-03	7.7e-04
4	NAcc	gene expression	LOC103692978	0.02	0.02	3.2e-03	0.02	0.01	0.02	0.01	4.1e-03	6.6e-03	3.2e-03	7.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	7.4	12.4	18.2	-4.3	4.1	-3.1	2.2
Area under the delay curve	0.7	0.8	1.3	-0.8	1.1	-1.0	-0.0
BMI with tail	3.1	10.2	15.3	-3.6	3.9	-3.4	1.0
BMI without tail	0.3	0.5	1.8	0.2	0.4	-0.4	-1.3
Body weight	4.8	20.0	29.6	-5.0	5.4	-5.1	-0.4
Weight adjusted by age	2.1	2.4	4.3	-1.5	1.6	-2.1	0.4
Bone surface	8.9	15.7	22.6	-4.7	4.5	-3.7	2.4
Bone volume	6.6	11.2	16.6	-4.1	3.8	-3.1	2.0
Breakpoint value in progressive ratio session	0.3	0.3	1.0	-0.2	0.3	-0.4	1.0
Number of licking bursts	0.8	0.9	2.6	0.9	-0.4	-0.4	-1.6
Context. condit. distance diff. score	0.5	0.5	1.3	-0.4	0.6	-0.6	-1.1
Locomotion velocity, session 1	1.0	1.1	1.8	1.0	-1.1	0.7	-1.3
Locomotion distance, session 1	2.4	3.1	5.2	1.8	-2.0	2.3	0.2
Locomotion velocity, session 2	0.3	0.3	0.6	0.4	-0.7	0.7	-0.1
Locomotion distance, session 2	2.0	2.7	4.5	1.6	-1.9	2.1	-0.1
Locomotion velocity, session 3	3.0	3.5	4.7	2.0	-2.1	2.2	-0.8
Locomotion distance, session 3	3.7	4.0	5.8	2.2	-2.4	2.4	-0.2
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	-1.3	1.1	-1.3	-0.3
Stereotopy head waving duration, day 3	0.4	0.5	0.7	-0.8	0.6	-0.8	-0.1
Locomotion velocity, session 7	0.4	0.4	1.4	0.4	-0.2	0.1	-1.2
Locomotion distance, session 7	1.1	1.4	2.0	1.4	-1.2	0.9	-1.2
Stereotopy head waving bouts, day 7	0.9	1.0	1.8	-1.1	0.9	-1.4	-0.1
Stereotopy head waving duration, day 7	1.0	1.3	2.3	-1.2	1.1	-1.5	0.0
Locomotion velocity, session 8	0.2	0.2	1.0	0.0	0.1	-0.1	-1.0
Locomotion distance, session 8	1.2	1.8	2.7	1.3	-1.4	1.6	-0.9
Degree of sensitization distance	0.6	0.6	1.0	-0.6	0.9	-1.0	-0.5
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.4	0.4	-0.9	-0.3
Conditioned locomotion	0.2	0.3	0.5	-0.3	0.1	-0.7	-0.7
Cocaine response after cond. corrected	0.3	0.4	0.9	0.1	0.1	0.8	0.9
Cocaine response after cond. not corrected	1.1	1.3	2.2	0.8	-0.8	1.5	1.2
Cocaine response before conditioning	2.8	3.4	6.0	2.0	-2.4	1.9	0.4
Saline control response	0.2	0.3	1.1	-0.4	0.0	-0.0	1.0
Bone: connectivity density	5.7	8.9	12.5	-3.5	3.3	-2.4	2.6
Bone: cortical apparent density	0.2	0.3	0.5	0.7	-0.7	0.3	-0.3
Bone: cortical area	7.8	11.8	16.2	-3.8	4.0	-3.6	2.0
Bone: cortical porosity	0.7	0.7	1.7	0.7	-1.3	0.9	0.0
Bone: cortical porosity	0.9	1.0	2.3	0.9	-1.5	1.0	-0.0
Bone: cortical thickness	3.2	5.3	7.8	-2.3	2.8	-2.4	1.6
Bone: cortical thickness	0.3	0.4	0.8	-0.3	0.6	-0.3	0.9
Bone: cortical tissue density	0.3	0.4	0.7	0.7	-0.8	0.5	-0.4
Condit. Reinf. active minus inactive responses	0.7	0.7	2.5	0.2	-0.2	0.6	1.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.7	-0.5	0.4	0.1	1.6
Condit. Reinf. active responses	0.8	1.0	1.6	0.8	-0.8	1.0	1.3
Condit. Reinf. inactive responses	1.9	2.3	3.4	1.9	-1.8	1.5	-0.3
Incentive salience index mean	0.2	0.2	0.8	-0.1	0.4	-0.0	0.9
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.4	0.8	-0.5	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.0	-0.3	-0.0	0.5
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.2	0.6	-0.6	0.5	1.1
Condit. Reinf. active responses	0.1	0.2	0.4	0.4	-0.6	0.3	0.2
Condit. Reinf. inactive responses	0.6	0.7	0.9	0.8	-1.0	0.6	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.0	-0.1	0.2	0.8
Condit. Reinf. lever reinforcers received	0.4	0.5	0.9	0.8	-0.9	0.7	0.2
Conditioned reinforcement - actives	1.0	1.0	1.5	1.1	-1.2	1.1	-0.1
Conditioned reinforcement - inactives	1.1	1.2	1.6	1.3	-1.3	1.2	-0.5
Conditioned locomotion	0.3	0.3	0.7	0.4	-0.6	0.2	-0.8
Patch foraging indifference point 0 sec	1.8	2.8	3.7	1.9	-1.9	1.7	-1.1
Patch foraging indifference point AUC	0.2	0.2	0.5	0.3	-0.7	0.3	0.4
Delay disc. indifference point, 0s delay	1.2	1.3	2.3	-1.2	1.2	-1.5	-0.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.8	-0.9	1.2	-1.3	-0.3
Delay disc. indifference point, 2s delay	0.8	0.9	1.3	-1.2	1.0	-1.1	-0.2
Delay disc. indifference point, 24s delay	1.2	1.1	1.7	-1.1	1.2	-1.3	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.4	0.5	-0.2	0.2
Delay disc. indifference point, 8s delay	1.9	2.0	3.2	-1.5	1.8	-1.6	0.4
Indifference point function ln k	2.7	3.8	5.5	-2.4	2.2	-2.1	0.4
Indifference point function log k	2.7	3.8	5.5	-2.4	2.2	-2.1	0.4
Patch foraging total patch changes 0 sec	1.7	2.8	3.6	1.9	-1.9	1.5	-1.2
Patch foraging total patch changes 12 sec	1.4	1.8	2.9	1.6	-1.7	1.2	-0.4
Patch foraging total patch changes 18 sec	3.0	3.8	6.5	2.2	-2.5	1.7	-1.0
Patch foraging total patch changes 24 sec	1.9	2.4	4.1	1.6	-1.5	0.7	-2.0
Patch foraging total patch changes 6 sec	1.7	2.6	3.7	1.8	-1.9	1.8	-0.3
Patch foraging time to switch 0 sec	1.9	2.9	4.1	2.0	-2.0	1.7	-0.8
Patch foraging water rate 0 sec	2.5	4.0	5.7	-2.2	2.4	-2.3	-0.0
Patch foraging water rate 12 sec	2.9	4.5	6.5	-2.6	2.5	-2.3	-0.2
Patch foraging water rate 18 sec	0.5	0.7	1.6	-0.4	0.8	-0.7	-1.2
Patch foraging water rate 24 sec	2.4	3.3	4.8	-2.0	2.1	-2.2	0.3
Patch foraging water rate 6 sec	2.9	4.3	6.0	-2.4	2.5	-2.3	0.3
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	3.9	-0.6	0.7	-0.0	2.0
Distance traveled before self-admin	1.3	1.3	2.4	1.2	-1.0	0.7	-1.6
Distance traveled after self-admin	0.3	0.3	0.7	0.4	-0.4	0.6	0.8
Extensor digitorum longus weight	3.4	13.2	19.7	-3.7	4.4	-4.4	-0.3
Bone: elastic displacement	3.7	4.2	5.7	2.4	-2.4	2.0	-1.1
Bone: elastic work	0.0	0.0	0.2	0.0	-0.2	0.1	-0.4
Bone: endosteal estimation	5.5	12.0	18.2	-4.3	3.8	-3.8	0.8
Bone: endosteal perimeter	5.4	11.1	14.2	-3.7	3.8	-3.6	1.8
Epididymis fat weight	0.3	0.7	0.9	-0.7	0.9	-0.8	-0.9
Delta time in closed arm before/after self-admin	0.6	0.6	1.9	-0.6	0.5	0.1	1.4
Delta time in open arm before/after self-admin	2.8	2.7	4.0	2.0	-1.9	1.7	-0.5
Diff in mean of infusions in LGA sessions	1.1	1.2	1.7	-1.3	1.3	-0.8	1.0
Delay discount exponential model param	0.6	0.6	1.1	0.8	-1.0	0.9	0.1
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.6	0.6	-0.7	0.4
Active lever presses in extinction session 6	1.1	1.1	3.6	-0.6	0.6	-0.3	1.9
Bone: final force	7.4	12.0	17.0	-4.1	4.1	-3.4	1.8
Bone: final moment	7.7	12.4	18.0	-4.2	4.1	-3.3	2.0
Food consumed during 24 hour testing period	2.9	3.5	9.8	-1.6	1.2	-0.6	3.1
Glucose	0.2	0.4	0.7	-0.1	0.6	-0.7	-0.8
Heart weight	0.5	0.8	2.9	-0.2	0.1	0.3	1.7
Delay discount hyperbolic model param	0.6	0.6	0.9	0.8	-1.0	0.9	0.1
Intermittent access intake day 1-15 change	0.9	0.9	1.3	1.2	-0.9	1.2	0.2
Intermittent access intake escalation	0.7	0.7	1.1	1.0	-0.7	1.0	0.3
Intermittent access intake escalation 2	1.0	1.0	1.5	1.2	-0.9	1.2	0.0
Intermitt. access day 1 inactive lever presses	2.7	2.9	4.0	1.8	-2.0	1.3	-1.6
Intermitt. access day 15 inactive lever presses	1.6	1.8	4.0	1.0	-1.3	0.7	-2.0
Intermitt. access escalation Index	0.8	0.7	1.8	0.8	-0.6	0.2	-1.3
Intermittent access day 1 total infusions	0.9	1.0	1.4	1.1	-1.2	1.2	0.3
Intermittent access day 15 total infusions	1.6	1.8	2.7	1.7	-1.5	1.5	-0.5
Intermittent access terminal intake (last 3 days)	1.8	1.9	2.7	1.7	-1.6	1.5	-0.3
Intermittent access total infusions	1.6	1.8	2.7	1.6	-1.5	1.5	-0.4
Intermittent access day 1 locomotion	1.0	1.0	2.2	1.0	-0.9	0.4	-1.5
Intermittent access day 15 total locomotion	1.6	1.7	4.4	1.2	-0.9	0.4	-2.1
Intermittent access total locomotion	2.8	3.1	5.5	1.9	-1.7	0.9	-2.4
Intermittent access standard deviation	0.6	0.6	0.9	0.8	-0.6	1.0	0.7
Left kidney weight	0.5	1.3	2.9	-1.1	1.2	-0.1	1.7
Right kidney weight	2.2	6.1	9.1	-2.9	3.0	-2.6	-0.3
Cocaine induced anxiety	0.9	1.0	1.4	-1.2	1.0	-1.2	-0.4
Post-drug Anxiety	3.3	3.6	5.8	-2.4	2.0	-2.2	0.1
Baseline Anxiety	0.7	0.7	1.1	-0.9	1.0	-1.0	-0.1
Tail length	0.2	0.7	2.6	0.4	-0.3	0.1	-1.6
Length with tail	1.5	5.6	7.8	-2.8	2.8	-2.6	-0.4
Length without tail	5.3	11.6	16.7	-4.1	4.0	-3.4	1.4
Times rat made contact with spout	0.4	0.5	1.5	0.5	-0.2	0.4	1.2
Lifetime Intake	1.4	1.6	2.7	1.6	-1.3	1.3	-0.5
Liver weight, left	1.5	2.3	3.8	-1.6	1.9	-1.7	-0.1
Liver weight, right	1.3	2.2	3.4	-1.4	1.8	-1.7	-0.7
Locomotor activity	0.5	0.8	1.5	1.2	-1.0	0.9	0.2
Locomotor testing distance	1.7	2.8	4.5	2.1	-1.9	1.7	-0.2
Locomotor testing rearing	1.6	2.4	3.8	1.9	-1.7	1.3	-1.2
Locomotion in novel chamber	0.5	0.7	1.1	-0.8	0.8	-1.1	-0.5
Locomotion in novel chamber post-restriction	0.7	0.8	2.4	-0.2	0.6	-0.8	-1.6
Fecal boli incidents, locomotor time 1	1.4	1.5	2.9	1.4	-1.0	1.7	0.2
Change in fecal boli incidents, locomotor task	1.0	0.9	1.7	-1.3	0.9	-1.1	-0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	-0.3	0.7	-0.5	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.0	0.5	-0.2	-0.7
Total resting periods, locomotor time 1	0.1	0.2	0.2	0.5	-0.0	0.4	-0.5
Rest time, locomotor task time 1	0.2	0.3	0.4	0.7	-0.3	0.4	-0.6
Distance moved, locomotor task time 1	0.1	0.1	0.4	-0.2	-0.3	0.2	0.6
Vertical activity count, locomotor time 1	1.3	1.4	2.2	-1.5	1.2	-0.7	1.2
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.6	0.7	-0.6	0.5	-0.6
Bouts of movement, locomotor time 2	2.7	3.0	4.0	-1.9	1.8	-2.0	-1.0
Total resting periods, locomotor time 2	3.0	3.3	4.3	-2.0	1.9	-2.1	-1.1
Rest time, locomotor task time 2	0.5	0.6	1.9	-0.0	0.5	-0.3	-1.4
Distance moved, locomotor task time 2	0.3	0.4	0.9	0.2	-0.6	0.5	1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.4	0.3	-0.4	0.1
Light reinforcement 1	2.1	3.7	5.2	2.2	-2.3	1.4	-1.8
Light reinforcement 2	0.8	1.1	2.0	1.0	-0.9	0.8	-1.4
Bone: marrow area	5.4	11.7	17.7	-4.2	3.8	-3.7	0.8
Bone: maximum diameter	3.2	6.0	8.2	-2.6	2.9	-2.7	1.2
Bone: maximum force	10.0	17.2	26.1	-5.1	4.8	-4.2	1.4
Bone: maximum moment	10.1	17.5	27.1	-5.2	4.8	-4.2	1.6
Mean time between licks in bursts	0.1	0.1	0.3	0.2	-0.5	0.5	-0.1
Mean num. licks in bursts	1.5	1.8	6.0	-0.2	-0.1	1.1	2.5
Cd content in liver	0.4	0.4	0.7	0.9	-0.6	0.6	-0.6
Co content in liver	0.4	0.4	0.8	0.9	-0.1	0.1	-0.9
Cu content in liver	0.8	1.0	1.5	-0.6	1.2	-1.0	-1.0
Fe content in liver	0.2	0.2	0.8	0.9	-0.3	0.3	-0.0
K content in liver	0.9	0.8	2.4	-0.4	0.7	-0.6	-1.5
Mg content in liver	0.2	0.2	0.6	-0.0	0.0	-0.0	-0.8
Mn content in liver	0.2	0.2	0.8	-0.3	0.1	-0.2	-0.9
Na content in liver	0.3	0.3	1.1	0.4	-0.0	-0.1	-1.0
Rb content in liver	0.6	0.7	2.3	0.8	-0.3	-0.0	-1.5
Se content in liver	0.4	0.5	0.8	0.9	-0.7	0.8	-0.3
Sr content in liver	0.5	0.5	0.9	-0.5	0.8	-1.0	-0.0
Zn content in liver	1.2	1.3	2.4	1.6	-1.1	0.6	-1.2
Bone: minimum diameter	7.0	13.1	16.9	-4.1	4.1	-4.0	1.8
Time in familiar zone, hab. session 1	0.6	0.6	0.9	0.6	-0.6	0.9	0.9
Time in novel zone, hab. session 1	1.0	1.0	2.2	-0.5	0.6	-1.1	-1.5
Total zone transitions, hab. session 1	1.0	1.4	4.6	0.7	-0.7	0.5	-2.1
Total locomotion distance, hab. session 1	0.1	0.2	0.6	-0.2	-0.1	0.2	-0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.3	-0.0	0.1	-0.8
Time in familiar zone, hab. session 2	0.4	0.5	1.3	-0.6	0.4	-0.0	1.1
Time in novel zone, hab. session 2	1.0	1.0	3.4	0.6	-0.5	-0.3	-1.8
Total zone transitions, hab. session 2	0.2	0.3	0.6	0.6	-0.5	0.8	-0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.2	-0.4	0.7	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.0	-0.2	0.5	-0.3
Novel to familiar place preference ratio	1.4	1.5	2.8	-1.2	1.3	-1.7	-0.2
Novelty place preference	1.1	1.1	2.2	-1.0	1.0	-1.5	-0.4
Time in novel zone, NPP test	1.0	1.0	2.1	-0.9	0.9	-1.5	-0.5
Total zone transitions, NPP test	0.9	1.3	2.3	1.3	-1.2	1.5	-0.0
Total locomotion distance, NPP test	1.4	1.9	3.1	1.4	-1.6	1.8	-0.3
Locomotion velocity, NPP test	0.8	1.1	2.0	1.0	-1.1	1.4	-0.1
Intraocular pressure	5.6	7.8	10.7	3.2	-3.3	2.9	-1.2
Delta distance traveled before/after self-admin	0.6	0.7	2.5	-0.4	0.2	0.2	1.6
Delta ambulatory time before/after self-admin	0.1	0.2	0.6	-0.2	0.1	0.1	0.8
Parametrial fat weight	1.6	3.0	4.7	2.2	-1.9	1.9	-0.5
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.3	-0.2	0.0	-0.5
Pavlov. Cond. magazine entry latency	0.5	0.7	2.5	-0.1	0.0	0.4	1.6
Pavlov. Cond. change in total contacts	0.3	0.4	1.3	-0.1	0.4	-0.2	1.1
Pavlov. Cond. index score	0.1	0.2	0.3	-0.1	0.6	-0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	0.5	-0.3	0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.8	-0.3	0.4	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	1.0	-0.2	-0.1	-0.2	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	0.6	-0.7	0.8	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.4	0.9	-0.6	0.5
Pavlov. Cond. response bias	0.4	0.5	1.6	0.3	-0.0	0.4	1.3
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.0	0.0	0.2
Pavlov. Cond. magazine entry latency	1.0	1.1	1.5	-1.2	0.9	-0.8	1.2
Pavlov. Cond. change in total contacts	1.1	1.6	2.3	-1.3	1.5	-1.1	1.0
Pavlov. Cond. index score	0.4	0.5	0.6	-0.7	0.8	-0.7	0.7
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.8	0.8	-0.7	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	-0.3	0.3	-0.0
Pavlov. Cond. magazine entry number	1.7	2.1	2.8	1.7	-1.6	1.6	-0.6
Pavlov. Cond. intertrial magazine entries	3.5	4.6	7.2	2.7	-2.4	2.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.0	-1.0	1.0	-1.0	0.8
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.1	0.1	0.2
Time in closed arm before self-admin	1.5	1.7	2.2	-1.4	1.0	-1.5	-1.2
Time in closed arm after self-admin	0.5	0.6	0.9	-1.0	0.6	-0.8	-0.6
Time in open arm before self-admin	1.1	1.2	1.9	-0.8	1.0	-1.2	-1.4
Time in open arm after self-admin	0.1	0.1	0.3	0.6	-0.4	0.4	0.1
Bone: periosteal estimation	9.1	18.8	25.5	-5.1	5.0	-4.6	1.9
Bone: periosteal perimeter	8.1	13.4	17.7	-4.1	4.2	-3.6	2.4
Bone: post-yield work	5.9	8.1	12.5	-3.5	3.1	-3.2	0.2
Progressive ratio test 1 active lever presses	3.1	3.2	5.3	2.3	-1.9	1.5	-1.3
Progressive ratio test 1 breakpoint	2.7	2.9	4.8	2.2	-1.8	1.3	-1.3
Progressive ratio test 1 inactive lever presses	2.7	2.9	4.4	2.1	-1.7	1.3	-1.6
Progressive ratio test 2 active lever presses	2.3	2.5	5.4	1.5	-1.3	0.9	-2.3
Progressive ratio test 2 breakpoint	2.7	3.1	5.6	1.7	-1.5	1.1	-2.4
Progressive ratio test 2 inactive lever presses	2.1	2.4	3.2	1.4	-1.7	1.3	-1.8
Incentive Sensitization - Responses	0.4	0.4	0.9	-0.6	0.4	-0.2	-1.0
Incentive Sensitization - Breakpoint	0.3	0.3	1.1	-0.4	0.2	-0.1	-1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	-0.4	0.3	-0.4
Progressive ratio	0.0	0.0	0.1	0.1	-0.2	0.2	-0.3
Food seeking constrained by brief footshock	0.9	1.1	3.7	0.7	-0.4	0.3	-1.9
Seeking ratio, punishment vs. effort	0.3	0.4	1.5	0.2	0.1	-0.2	-1.2
Retroperitoneal fat weight	0.3	1.0	1.8	1.3	-0.7	1.3	0.4
Reaction time number correct	1.1	1.6	3.0	-1.7	1.0	-0.9	1.3
Reaction time mean minus median	7.1	9.4	13.2	3.4	-3.3	3.6	1.4
Reaction time mean minus median AUC	5.1	6.7	9.7	2.9	-2.8	3.1	0.9
Reaction time num false alarms	1.6	2.2	3.1	1.5	-1.8	1.7	0.6
Reaction time num false alarms AUC	2.4	3.3	5.1	1.8	-2.1	2.3	0.7
Reaction time trials correct on left	1.1	1.6	3.0	-1.7	1.0	-0.9	1.3
Reaction time trials on left	0.9	1.3	2.4	-1.6	0.9	-0.7	1.3
Reaction time mean	0.4	0.6	0.9	0.9	-0.6	0.9	0.3
Reaction time mean AUC	0.3	0.4	0.6	0.7	-0.4	0.8	0.6
Median of all reaction times	0.1	0.1	0.2	-0.2	0.5	-0.2	-0.1
Reaction time omissions	7.1	9.7	12.9	3.6	-3.6	3.6	0.2
Reaction time false alarm rate	2.3	3.2	4.3	2.1	-2.0	2.1	0.1
Reaction time premature initiation rate	4.2	5.7	9.0	3.0	-2.9	2.1	-1.0
Reaction time premature initiations	2.0	2.9	5.0	2.0	-2.2	1.6	-0.2
Std. dev. reaction times	4.8	6.7	9.4	3.0	-2.8	3.1	0.8
Reaction time trials completed	0.9	1.3	2.4	-1.6	0.9	-0.7	1.3
Reaction time trials AUC	1.4	2.0	3.6	-1.9	1.2	-1.1	1.3
Run reversals in cocaine runway, females	0.2	0.1	0.6	0.1	-0.2	0.1	0.7
Run reversals in cocaine runway, males	1.0	1.0	1.5	1.2	-1.2	1.1	0.0
Latency to leave start box in cocaine runway	0.1	0.1	0.5	0.1	-0.1	-0.1	-0.7
Latency to leave start box in cocaine runway, F	1.4	1.5	1.9	1.3	-1.4	1.0	-1.2
Latency to leave start box in cocaine runway, M	1.6	1.5	1.9	-1.4	1.4	-1.1	0.9
Std. dev. time between licks in bursts	0.8	0.9	1.1	1.0	-1.0	0.6	-1.1
Total sessions with >9 infusions	0.4	0.4	0.9	0.9	-0.5	0.3	-0.8
Short access day 1 total inactive lever presses	1.4	1.6	3.0	1.3	-1.0	0.8	-1.7
Short access day 10 total inactive lever presses	0.5	0.6	1.3	0.6	-0.7	0.3	-1.2
Short access day 1 total infusions	0.3	0.3	1.1	0.2	0.2	-0.3	-1.1
Short access day 10 total infusions	0.5	0.5	1.1	1.1	-0.5	0.9	0.1
Short access total infusions	0.2	0.2	0.6	0.7	-0.3	0.3	-0.5
Short access day 1 locomotion	1.8	1.9	6.9	0.5	0.1	-0.6	-2.6
Short access day 10 total locomotion	1.0	1.1	3.9	0.5	-0.3	-0.4	-2.0
Short access total locomotion	1.4	1.5	5.2	0.7	-0.3	-0.3	-2.3
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.5	-0.3	0.6	0.3
Compulsive drug intake	0.5	0.5	0.8	-0.9	0.6	-0.5	0.7
One hour access (shock baseline)	0.1	0.1	0.2	0.2	0.1	0.1	-0.5
Social response proportion	0.3	0.3	0.5	0.4	-0.5	0.7	0.7
Social responses	6.0	7.7	11.0	3.3	-3.3	3.0	-0.3
Social time	0.6	0.8	2.5	0.1	-0.2	0.8	1.6
Soleus weight	0.5	1.4	2.0	-1.3	1.4	-1.4	-0.2
Bone: stiffness	12.2	19.3	28.5	-5.3	5.1	-4.5	1.5
Tibialis anterior weight	1.3	4.4	7.0	-1.3	2.5	-2.6	-1.6
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.0	1.1	-1.4	1.3	0.9
Time to tail flick, vehicle, after self-admin	0.9	1.0	2.8	-0.5	0.4	-0.8	-1.7
Time to tail flick, test, before self-admin	0.3	0.3	0.4	0.5	-0.6	0.6	-0.5
Time to tail flick, test, after self-admin	0.2	0.3	0.5	-0.5	0.5	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	-0.7	0.9	-0.8	-1.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.3	0.5	-0.5	-0.2
Tibia length	5.5	15.4	21.5	-4.6	4.6	-4.4	-0.2
Ambulatory time before self-admin	3.2	3.3	4.7	2.2	-1.9	1.5	-1.6
Ambulatory time after self-admin	1.1	1.2	1.9	1.4	-1.3	1.0	-0.4
Bone: tissue strength	0.6	0.6	1.2	-1.1	0.7	-0.8	-0.2
Total heroin consumption	2.3	2.7	4.6	-1.5	1.5	-2.1	-1.3
Bone: trabecular number	4.8	7.5	11.0	-3.3	2.9	-1.8	2.7
Bone: trabecular spacing	1.8	2.3	3.5	1.7	-1.6	0.7	-1.9
Bone: trabecular thickness	0.7	0.8	2.6	0.3	-0.3	0.7	1.6
Bone: trabecular tissue density	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1
Water consumed over 24 hours	0.3	0.4	1.5	-0.3	-0.1	0.1	1.2
Number of responses in last shaping day	1.2	1.3	4.1	-0.1	0.4	-0.9	-2.0