Hub : Genes

LOC103691888

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC103691888	0.31	0.33	1.7e-16	0.13	0.14	0.14	0.14	2.3e-14	1.1e-15	1.4e-15	3.9e-15
2	pVTA	gene expression	LOC103691888	0.87	0.03	3.2e-08	0.14	-0.01	0.09	-0	1.6e-06	9.6e-01	7.3e-05	4.4e-01
3	BLA	gene expression	LOC103691888	0.34	0.2	1.0e-13	0.2	0.08	0.16	0.19	8.9e-11	7.1e-05	4.3e-09	3.0e-10
4	Brain	gene expression	LOC103691888	0.27	0.16	0.0e+00	0.26	0.26	0.26	0.26	1.1e-23	1.2e-23	4.8e-24	8.2e-24
5	Liver	gene expression	LOC103691888	0.12	0.12	4.9e-09	0.05	0.05	0.05	0.05	2.5e-06	2.4e-06	2.5e-06	2.0e-06
6	NAcc	gene expression	LOC103691888	0.19	0.1	0.0e+00	0.22	0.23	0.22	0.23	4.8e-25	3.3e-26	1.1e-25	5.7e-26
7	OFC	gene expression	LOC103691888	0.43	0.22	3.5e-08	0.29	0.32	0.32	0.31	1.1e-07	2.5e-08	2.7e-08	3.2e-08
8	IL	gene expression	LOC103691888	0.35	0.23	3.3e-05	0.06	0.07	0.07	0.04	1.8e-02	1.1e-02	7.7e-03	3.4e-02
9	Adipose	gene expression	LOC103691888	0.11	0.2	8.2e-05	0.01	0.03	0.03	0.03	1.8e-02	5.8e-04	6.1e-04	2.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.3	0.5	0.7	0.9	-0.8	-0.8	-0.8	0.8	0.8	0.7	-0.3	-0.3
Area under the delay curve	0.2	0.2	0.6	-0.5	0.4	0.8	0.5	-0.5	-0.5	-0.5	0.1	0.2
BMI with tail	1.3	4.3	5.7	2.0	-2.4	-2.2	-2.1	2.2	2.0	1.9	-2.1	1.7
BMI without tail	4.2	8.7	10.0	2.9	-3.2	-3.1	-3.1	3.1	2.9	2.9	-3.0	2.5
Body weight	6.2	25.8	30.4	5.2	-5.5	-5.3	-5.2	5.0	5.2	5.1	-4.8	4.2
Weight adjusted by age	3.3	3.7	4.6	2.1	-2.1	-2.1	-2.0	2.1	2.1	2.1	-1.6	0.8
Bone surface	0.6	1.0	1.4	1.2	-1.1	-1.1	-1.1	1.1	1.1	1.1	-0.7	0.2
Bone volume	0.5	0.9	1.3	1.1	-1.0	-1.1	-1.0	1.1	1.0	1.0	-0.6	0.1
Breakpoint value in progressive ratio session	3.4	3.7	4.6	1.8	-1.9	-1.9	-1.9	2.0	1.9	1.9	-2.1	2.1
Number of licking bursts	0.1	0.2	0.3	-0.5	0.5	0.4	0.5	-0.5	-0.4	-0.4	0.2	0.3
Context. condit. distance diff. score	0.1	0.1	0.4	0.2	-0.2	-0.2	-0.2	0.2	0.1	0.1	0.1	-0.6
Locomotion velocity, session 1	0.3	0.3	0.3	0.6	-0.5	-0.6	-0.6	0.6	0.6	0.6	-0.5	0.5
Locomotion distance, session 1	0.2	0.2	0.5	0.6	-0.5	-0.5	-0.5	0.6	0.4	0.4	-0.0	-0.7
Locomotion velocity, session 2	0.1	0.1	0.2	-0.3	0.4	0.4	0.3	-0.3	-0.3	-0.3	0.3	-0.5
Locomotion distance, session 2	0.9	1.3	1.7	1.3	-1.1	-1.3	-1.2	1.3	1.2	1.2	-0.8	-0.1
Locomotion velocity, session 3	1.3	1.6	1.9	1.3	-1.3	-1.1	-1.3	1.3	1.2	1.2	-1.4	1.1
Locomotion distance, session 3	6.9	7.5	8.7	2.8	-2.9	-2.7	-2.9	3.0	2.7	2.7	-2.8	2.2
Stereotopy head waving bouts, day 3	1.7	2.0	3.4	-1.1	1.5	1.4	1.4	-1.5	-1.2	-1.2	1.6	-1.8
Stereotopy head waving duration, day 3	1.0	1.2	1.6	-0.9	1.2	1.1	1.1	-1.2	-1.0	-0.9	1.2	-1.2
Locomotion velocity, session 7	0.7	0.8	1.0	1.0	-0.9	-0.9	-1.0	0.9	1.0	1.0	-0.9	0.6
Locomotion distance, session 7	0.4	0.6	0.8	0.8	-0.8	-0.8	-0.9	0.9	0.7	0.7	-0.7	0.1
Stereotopy head waving bouts, day 7	0.5	0.5	0.7	0.8	-0.6	-0.7	-0.7	0.6	0.8	0.8	-0.7	0.8
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.4	-0.3	-0.4	-0.3	0.3	0.5	0.5	-0.4	0.6
Locomotion velocity, session 8	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.6	0.5	0.6	0.5	-0.1	-0.6
Locomotion distance, session 8	1.5	2.2	3.0	1.7	-1.6	-1.7	-1.7	1.7	1.5	1.5	-1.0	-0.3
Degree of sensitization distance	2.5	2.5	2.7	-1.6	1.6	1.5	1.6	-1.6	-1.6	-1.6	1.7	-1.6
Degree of sensitization stereotypy	2.7	3.0	3.7	1.7	-1.6	-1.7	-1.7	1.6	1.7	1.8	-1.8	1.9
Conditioned locomotion	3.9	4.5	5.7	2.4	-2.3	-2.3	-2.2	2.3	2.3	2.2	-1.7	1.1
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.3	0.3	0.4	0.3	-0.2	-0.4	-0.4	0.4	-0.5
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.4	-0.5	-0.5	0.4	-0.5
Cocaine response before conditioning	0.2	0.2	0.5	-0.5	0.7	0.5	0.5	-0.6	-0.4	-0.4	0.4	-0.1
Saline control response	7.4	9.7	11.4	3.3	-3.4	-3.2	-3.2	3.2	3.2	3.2	-2.9	2.3
Bone: connectivity density	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.4	0.4	0.5	0.4	0.0	-0.5
Bone: cortical apparent density	0.9	1.1	2.5	0.9	-0.9	-0.9	-1.0	0.9	1.0	1.0	-1.3	1.6
Bone: cortical area	3.6	5.4	6.1	2.4	-2.5	-2.4	-2.5	2.4	2.3	2.3	-2.3	1.8
Bone: cortical porosity	0.4	0.5	1.8	0.3	-0.5	-0.4	-0.5	0.6	0.4	0.4	-1.0	1.3
Bone: cortical porosity	1.0	1.1	2.6	0.7	-0.9	-0.8	-0.9	1.0	0.8	0.8	-1.4	1.6
Bone: cortical thickness	1.7	2.8	3.1	1.7	-1.8	-1.7	-1.8	1.7	1.6	1.6	-1.8	1.5
Bone: cortical thickness	0.4	0.4	0.5	0.6	-0.6	-0.6	-0.7	0.6	0.6	0.6	-0.7	0.7
Bone: cortical tissue density	0.7	0.9	2.1	0.8	-0.8	-0.8	-0.9	0.8	0.9	0.9	-1.1	1.5
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	0.9	-1.0	-0.9	-1.0	1.0	0.9	0.9	-1.1	1.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.9	0.9	-0.9	-0.9	-0.9	0.9	0.9	0.9	-0.8	0.4
Condit. Reinf. active responses	0.7	0.9	1.2	0.8	-1.0	-0.9	-0.9	1.0	0.8	0.8	-1.1	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.1	-0.0	-0.0	-0.1	0.1
Incentive salience index mean	0.6	0.7	1.0	0.8	-0.9	-0.8	-0.9	1.0	0.7	0.7	-1.0	0.8
Condit. Reinf. lever presses	0.2	0.2	0.4	0.3	-0.5	-0.3	-0.5	0.6	0.3	0.3	-0.6	0.5
Condit. Reinf. active minus inactive responses	1.8	2.2	3.1	1.8	-1.5	-1.6	-1.5	1.4	1.7	1.7	-1.2	0.7
Condit. Reinf. active-inactive response ratio	2.0	2.0	2.7	1.6	-1.4	-1.5	-1.4	1.4	1.6	1.6	-1.2	0.9
Condit. Reinf. active responses	2.9	4.0	5.4	2.3	-1.9	-2.1	-2.1	1.9	2.3	2.3	-1.6	1.0
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.9	-0.8	-0.8	-0.8	0.8	0.9	0.9	-0.4	-0.0
Condit. Reinf. lever presses	1.3	1.7	2.3	1.4	-1.1	-1.3	-1.3	1.2	1.5	1.5	-1.2	1.1
Condit. Reinf. lever reinforcers received	2.1	3.0	4.2	2.1	-1.7	-1.8	-1.8	1.7	2.0	2.0	-1.3	0.7
Conditioned reinforcement - actives	0.0	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0	0.1	0.1	0.1	-0.2
Conditioned reinforcement - inactives	0.3	0.3	0.8	0.7	-0.5	-0.4	-0.4	0.4	0.6	0.6	0.2	-0.9
Conditioned locomotion	0.1	0.1	0.1	-0.3	0.3	0.2	0.3	-0.3	-0.3	-0.3	0.3	-0.3
Patch foraging indifference point 0 sec	0.1	0.2	1.0	0.4	0.0	-0.2	-0.1	-0.1	0.3	0.3	0.5	-1.0
Patch foraging indifference point AUC	0.6	0.7	0.9	0.9	-1.0	-0.9	-0.9	0.9	0.8	0.8	-0.8	0.7
Delay disc. indifference point, 0s delay	2.3	2.5	3.5	-1.9	1.7	1.6	1.7	-1.6	-1.7	-1.7	1.3	-0.6
Delay disc. indifference point, 16s delay	0.5	0.6	1.0	-0.8	0.6	1.0	0.8	-0.8	-0.9	-0.9	0.4	-0.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.2	-0.1	0.0	0.5	0.2	-0.1	-0.1	-0.1	0.0	0.0
Delay disc. indifference point, 24s delay	2.2	2.2	3.0	-1.6	1.4	1.7	1.6	-1.5	-1.6	-1.6	1.2	-0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.6	0.1	-0.2	-0.1	-0.2	0.2	0.1	0.2	-0.5	0.8
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	-0.6	0.6	0.8	0.5	-0.5	-0.5	-0.5	0.1	0.4
Indifference point function ln k	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	0.3	0.3	-0.2	-0.1
Indifference point function log k	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	0.3	0.3	-0.2	-0.1
Patch foraging total patch changes 0 sec	0.1	0.2	1.0	0.4	-0.1	-0.3	-0.2	0.0	0.3	0.3	0.5	-1.0
Patch foraging total patch changes 12 sec	0.4	0.5	0.8	0.8	-0.8	-0.9	-0.8	0.8	0.8	0.7	-0.5	0.3
Patch foraging total patch changes 18 sec	0.9	1.1	1.9	-0.9	1.0	0.7	0.9	-1.1	-0.9	-1.0	1.4	-1.4
Patch foraging total patch changes 24 sec	1.8	2.2	3.4	-1.3	1.5	1.3	1.4	-1.5	-1.3	-1.3	1.8	-1.8
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	0.9	-0.6	-0.8	-0.7	0.7	0.8	0.8	-0.0	-0.7
Patch foraging time to switch 0 sec	1.5	2.3	3.5	-1.9	1.6	1.5	1.6	-1.6	-1.8	-1.8	1.1	-0.4
Patch foraging water rate 0 sec	3.0	4.9	7.3	2.7	-2.2	-2.2	-2.3	2.3	2.6	2.6	-1.6	0.6
Patch foraging water rate 12 sec	0.1	0.1	0.7	0.3	-0.0	-0.0	-0.0	-0.1	0.2	0.2	0.4	-0.9
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.7	-0.6	-0.2	-0.5	0.7	0.7	0.7	-0.5	0.2
Patch foraging water rate 24 sec	0.4	0.6	0.8	0.8	-0.8	-0.6	-0.7	0.6	0.9	0.9	-0.8	0.9
Patch foraging water rate 6 sec	1.8	2.6	3.2	1.7	-1.6	-1.7	-1.7	1.4	1.8	1.8	-1.4	1.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.6	0.5	0.4	0.5	-0.5	-0.5	-0.5	0.3	0.1
Distance traveled before self-admin	4.7	5.0	6.9	2.4	-2.2	-2.6	-2.3	2.4	2.4	2.3	-1.9	1.3
Distance traveled after self-admin	2.8	3.1	4.9	1.8	-1.8	-2.2	-1.8	1.9	1.8	1.8	-1.4	0.8
Extensor digitorum longus weight	0.1	0.3	0.4	0.5	-0.5	-0.5	-0.5	0.4	0.5	0.5	-0.5	0.6
Bone: elastic displacement	0.1	0.1	0.6	-0.1	-0.1	-0.0	-0.0	0.0	0.0	0.0	-0.4	0.8
Bone: elastic work	0.1	0.1	0.4	0.1	-0.2	-0.3	-0.2	0.2	0.2	0.2	-0.4	0.6
Bone: endosteal estimation	0.5	1.0	1.2	1.1	-1.1	-1.1	-1.1	1.1	1.1	1.0	-0.9	0.7
Bone: endosteal perimeter	2.1	4.4	5.0	2.2	-2.2	-2.2	-2.2	2.2	2.2	2.2	-1.9	1.4
Epididymis fat weight	1.4	3.3	3.9	1.9	-1.9	-1.9	-1.9	2.0	1.8	1.8	-1.8	1.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	0.5	0.6	0.5	-0.5	-0.5	-0.5	0.4	-0.3
Delta time in open arm before/after self-admin	0.6	0.6	0.8	0.9	-0.7	-0.9	-0.8	0.8	0.8	0.8	-0.1	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.0	-0.0	-0.1	-0.1	-0.1	0.3
Delay discount exponential model param	0.2	0.2	0.5	0.5	-0.4	-0.7	-0.5	0.4	0.5	0.5	-0.1	-0.3
Extinction: sum of active levers before priming	0.6	0.6	0.8	0.8	-0.6	-0.7	-0.8	0.7	0.9	0.9	-0.8	0.7
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.4	0.3	0.1	0.4	-0.2	-0.3	-0.4	0.5	-0.6
Bone: final force	3.9	6.3	7.4	2.6	-2.7	-2.6	-2.6	2.6	2.5	2.5	-2.4	2.1
Bone: final moment	3.0	4.9	5.8	2.3	-2.4	-2.3	-2.3	2.3	2.2	2.2	-2.2	1.8
Food consumed during 24 hour testing period	0.9	1.1	1.7	-0.9	0.9	0.9	1.1	-1.1	-1.0	-1.0	1.3	-1.2
Glucose	0.3	0.4	0.7	0.8	-0.7	-0.8	-0.7	0.7	0.7	0.7	-0.3	0.0
Heart weight	2.8	4.0	5.4	2.3	-2.3	-2.0	-2.1	2.2	2.1	2.1	-1.7	0.8
Delay discount hyperbolic model param	0.2	0.2	0.5	0.4	-0.3	-0.7	-0.4	0.4	0.4	0.4	-0.1	-0.2
Intermittent access intake day 1-15 change	0.4	0.4	0.6	0.7	-0.7	-0.7	-0.7	0.7	0.7	0.7	-0.5	0.3
Intermittent access intake escalation	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.3	0.4	0.4	-0.2	0.1
Intermittent access intake escalation 2	0.2	0.2	0.2	-0.4	0.3	0.4	0.5	-0.4	-0.4	-0.5	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.7	0.7	2.3	-0.4	0.7	0.8	0.8	-0.8	-0.5	-0.5	1.1	-1.5
Intermitt. access day 15 inactive lever presses	0.2	0.2	1.5	-0.0	0.1	0.1	0.2	-0.2	-0.1	-0.1	0.6	-1.2
Intermitt. access escalation Index	0.1	0.1	0.4	-0.0	-0.0	-0.1	-0.1	0.1	-0.0	0.0	-0.3	0.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	0.1	0.0	0.1	-0.0	-0.3	-0.3	-0.0	0.2
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.1	0.1	-0.0	-0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.2	0.0	-0.1	-0.1	-0.0	0.1	-0.0	-0.0	0.1	-0.4
Intermittent access total infusions	0.0	0.0	0.1	-0.2	0.0	0.0	0.1	0.0	-0.2	-0.2	0.1	-0.3
Intermittent access day 1 locomotion	0.2	0.2	0.4	-0.4	0.5	0.4	0.4	-0.4	-0.3	-0.3	0.5	-0.6
Intermittent access day 15 total locomotion	0.3	0.3	1.7	-0.2	0.3	0.2	0.3	-0.2	-0.3	-0.3	0.7	-1.3
Intermittent access total locomotion	0.1	0.2	0.5	-0.3	0.3	0.2	0.3	-0.2	-0.3	-0.4	0.5	-0.7
Intermittent access standard deviation	0.1	0.1	0.3	0.2	-0.3	-0.2	-0.2	0.2	0.3	0.3	-0.4	0.5
Left kidney weight	1.0	2.7	3.9	1.7	-2.0	-1.7	-1.7	1.8	1.6	1.6	-1.4	0.8
Right kidney weight	0.8	2.2	3.6	1.6	-1.9	-1.7	-1.5	1.5	1.6	1.5	-1.1	0.5
Cocaine induced anxiety	6.2	7.1	8.3	-2.4	2.7	2.7	2.7	-2.7	-2.5	-2.5	2.9	-2.9
Post-drug Anxiety	2.0	2.3	2.6	-1.3	1.6	1.6	1.6	-1.6	-1.4	-1.3	1.6	-1.5
Baseline Anxiety	0.7	0.7	1.2	0.8	-0.8	-0.8	-0.8	0.8	0.8	0.8	-1.0	1.1
Tail length	5.2	15.7	16.4	3.9	-4.0	-4.1	-4.0	4.0	4.0	4.0	-4.0	3.7
Length with tail	4.6	16.7	18.8	4.3	-4.3	-4.2	-4.2	4.1	4.2	4.2	-3.8	3.2
Length without tail	1.2	2.6	3.5	1.8	-1.9	-1.6	-1.6	1.5	1.7	1.7	-1.4	1.2
Times rat made contact with spout	0.1	0.1	0.6	-0.0	0.2	0.0	0.2	-0.2	-0.1	-0.1	0.6	-0.8
Lifetime Intake	0.1	0.2	0.3	0.3	-0.4	-0.5	-0.4	0.6	0.3	0.3	-0.4	0.3
Liver weight, left	0.1	0.2	0.9	-0.2	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.7	-0.9
Liver weight, right	0.1	0.2	0.8	0.1	-0.4	-0.3	-0.3	0.4	0.2	0.2	-0.7	0.9
Locomotor activity	0.1	0.2	0.4	0.5	-0.4	-0.1	-0.4	0.3	0.5	0.5	-0.5	0.6
Locomotor testing distance	0.2	0.3	0.7	-0.4	0.7	0.8	0.6	-0.6	-0.4	-0.3	0.5	-0.6
Locomotor testing rearing	0.1	0.1	0.3	0.6	-0.2	-0.1	-0.3	0.2	0.5	0.5	-0.0	-0.4
Locomotion in novel chamber	0.1	0.1	0.4	-0.4	0.2	0.6	0.4	-0.4	-0.4	-0.3	0.1	0.1
Locomotion in novel chamber post-restriction	0.8	1.0	1.4	1.2	-0.9	-0.8	-1.0	0.9	1.1	1.2	-1.0	0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.3	0.3	0.3	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.3	0.3	0.3	-0.3	-0.3	-0.3	0.4	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.3	0.3	0.3	0.3	-0.4	0.4
Bouts of movement, locomotor time 1	1.7	1.9	2.5	-1.6	1.4	1.3	1.4	-1.4	-1.5	-1.5	1.2	-0.8
Total resting periods, locomotor time 1	1.3	1.5	2.1	-1.4	1.3	1.2	1.3	-1.3	-1.3	-1.3	1.0	-0.6
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.5	-0.5	-0.5	0.4	-0.2
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.2	0.1	0.1	-0.1	-0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.5	-0.6	-0.5	-0.5	0.5	0.3	0.3	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.1	0.1	-0.1	-0.1	-0.1	0.1
Bouts of movement, locomotor time 2	0.4	0.4	0.7	-0.8	0.6	0.8	0.7	-0.6	-0.7	-0.7	0.4	-0.1
Total resting periods, locomotor time 2	0.4	0.4	0.7	-0.8	0.7	0.8	0.8	-0.6	-0.7	-0.7	0.4	0.1
Rest time, locomotor task time 2	0.5	0.6	1.3	-0.8	1.2	1.0	0.9	-1.0	-0.6	-0.5	0.6	-0.1
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.1	-0.4	-0.2	-0.2	0.2	-0.1	-0.1	0.1	-0.6
Vertical activity count, locomotor time 2	0.3	0.3	0.8	0.6	-0.7	-0.6	-0.5	0.6	0.3	0.3	0.1	-0.9
Light reinforcement 1	0.8	1.5	1.8	1.2	-1.2	-1.2	-1.2	1.1	1.3	1.3	-1.2	1.2
Light reinforcement 2	0.6	0.8	0.9	0.9	-0.9	-0.8	-0.9	0.9	0.9	0.9	-0.9	0.7
Bone: marrow area	0.4	0.9	1.1	1.0	-1.0	-1.0	-1.0	1.0	1.0	1.0	-0.9	0.6
Bone: maximum diameter	4.5	8.2	9.4	3.0	-3.1	-3.0	-3.0	3.0	2.9	2.9	-2.6	2.0
Bone: maximum force	0.7	1.2	1.5	1.2	-1.2	-1.2	-1.2	1.1	1.1	1.1	-1.0	0.8
Bone: maximum moment	0.3	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.7	0.7	0.7	-0.6	0.5
Mean time between licks in bursts	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.2	0.0	-0.0	-0.3	0.4
Mean num. licks in bursts	0.1	0.2	0.5	0.5	-0.4	-0.4	-0.4	0.3	0.3	0.3	0.1	-0.7
Cd content in liver	0.1	0.1	0.3	-0.3	0.4	0.3	0.3	-0.2	-0.4	-0.4	0.3	-0.5
Co content in liver	0.7	0.8	0.9	1.0	-0.9	-1.0	-0.9	0.9	0.9	0.9	-0.8	0.5
Cu content in liver	1.8	2.2	2.6	1.6	-1.5	-1.6	-1.5	1.5	1.6	1.6	-1.3	0.9
Fe content in liver	0.0	0.1	0.4	-0.0	0.2	0.2	0.1	-0.1	-0.0	-0.0	0.3	-0.6
K content in liver	0.4	0.4	0.6	0.6	-0.8	-0.7	-0.6	0.6	0.5	0.5	-0.5	0.5
Mg content in liver	1.7	1.7	2.2	1.4	-1.5	-1.4	-1.4	1.3	1.3	1.3	-1.1	0.8
Mn content in liver	2.0	2.2	2.4	1.5	-1.5	-1.5	-1.5	1.5	1.5	1.5	-1.5	1.3
Na content in liver	0.0	0.0	0.0	-0.2	0.1	0.1	0.1	-0.1	-0.2	-0.2	0.1	-0.1
Rb content in liver	3.2	3.9	5.3	2.3	-2.2	-2.3	-2.1	2.2	2.1	2.1	-1.4	0.4
Se content in liver	0.6	0.7	1.0	1.0	-0.9	-0.8	-0.9	0.9	1.0	1.0	-0.7	0.3
Sr content in liver	0.6	0.5	0.7	0.7	-0.6	-0.7	-0.7	0.8	0.7	0.7	-0.8	0.8
Zn content in liver	0.2	0.3	0.3	0.5	-0.5	-0.6	-0.6	0.6	0.5	0.5	-0.4	0.2
Bone: minimum diameter	1.7	3.1	3.7	1.8	-1.9	-1.8	-1.9	1.9	1.8	1.7	-1.7	1.2
Time in familiar zone, hab. session 1	1.5	1.4	1.5	-1.2	1.2	1.2	1.2	-1.2	-1.2	-1.2	1.1	-1.0
Time in novel zone, hab. session 1	0.4	0.4	0.6	0.7	-0.7	-0.7	-0.7	0.8	0.7	0.7	-0.6	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.3	-0.4	-0.3	-0.4	0.5	0.3	0.2	-0.3	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.6	0.1	0.0	-0.0	-0.1	0.1	-0.0	-0.0	0.2	-0.8
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.2	0.3	0.2	0.1	0.0	-0.6
Time in familiar zone, hab. session 2	1.8	1.8	1.9	-1.3	1.3	1.4	1.4	-1.4	-1.4	-1.4	1.4	-1.3
Time in novel zone, hab. session 2	1.8	1.8	1.8	1.3	-1.3	-1.3	-1.3	1.4	1.4	1.4	-1.3	1.3
Total zone transitions, hab. session 2	2.5	3.2	4.0	1.8	-1.8	-1.8	-1.9	2.0	1.8	1.8	-1.9	1.4
Total locomotion distance, hab. session 2	0.4	0.6	0.9	0.9	-0.7	-0.8	-0.9	0.9	0.8	0.8	-0.6	-0.1
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.5	-0.4	-0.5	-0.5	0.6	0.5	0.4	-0.2	-0.5
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.4	0.4	0.3	0.4	-0.4	-0.4	-0.4	0.6	-0.6
Novelty place preference	0.4	0.4	0.6	-0.6	0.6	0.5	0.6	-0.6	-0.6	-0.6	0.8	-0.7
Time in novel zone, NPP test	0.2	0.2	0.3	-0.4	0.4	0.3	0.4	-0.4	-0.4	-0.5	0.6	-0.6
Total zone transitions, NPP test	0.2	0.2	0.5	0.4	-0.5	-0.4	-0.5	0.6	0.3	0.3	-0.7	0.6
Total locomotion distance, NPP test	0.1	0.1	0.3	0.4	-0.4	-0.4	-0.4	0.5	0.3	0.3	-0.2	-0.4
Locomotion velocity, NPP test	0.0	0.1	0.4	0.1	0.0	0.0	-0.0	0.1	-0.0	-0.0	0.2	-0.7
Intraocular pressure	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.1	-0.2	0.2	0.2	0.0	0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.4	-0.5	-0.6	-0.5	0.5	0.5	0.5	-0.5	0.4
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	-0.8	0.6	0.5	0.6	-0.6	-0.8	-0.8	0.4	-0.2
Parametrial fat weight	0.0	0.1	0.2	-0.3	-0.2	0.2	0.1	0.0	-0.4	-0.4	-0.0	0.0
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.5	-0.2	-0.4	-0.3	0.1	0.5	0.6	-0.3	0.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.3	0.2	0.2	-0.2	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.3	0.1	0.1	-0.3	0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.1	0.2	-0.1	-0.1	-0.1	-0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.3	0.1	0.2	0.2	-0.0	-0.3	-0.3	0.1	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.4	0.5	0.2	0.1	-0.3	-0.0
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	-0.8	0.9	0.9	0.9	-0.9	-0.9	-0.9	1.1	-1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.2	0.3	0.3	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0	0.1	-0.1	-0.1	-0.1	-0.0
Pavlov. Cond. response bias	0.5	0.6	0.7	0.7	-0.8	-0.7	-0.8	0.9	0.7	0.7	-0.8	0.7
Pavlov. Cond. lever latency	3.9	5.3	6.1	-2.4	2.1	2.3	2.4	-2.2	-2.4	-2.5	2.3	-2.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	-0.1	-0.3	-0.2	0.2	0.3	0.3	0.0	-0.4
Pavlov. Cond. change in total contacts	3.7	5.1	6.0	2.4	-2.1	-2.2	-2.3	2.2	2.4	2.4	-2.3	2.0
Pavlov. Cond. index score	3.1	4.0	4.7	2.1	-1.8	-2.1	-2.1	2.0	2.1	2.2	-2.0	1.6
Pavlov. Cond. latency score	2.4	2.9	3.5	1.8	-1.6	-1.8	-1.8	1.7	1.9	1.9	-1.7	1.2
Pavlov. Cond. lever contacts	3.7	5.1	6.0	2.4	-2.1	-2.4	-2.3	2.2	2.4	2.4	-2.1	1.9
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.9	0.6	0.8	0.8	-0.7	-0.9	-0.9	0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.5	-1.2	1.0	1.2	1.1	-1.1	-1.2	-1.2	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.5	4.1	2.0	-1.7	-1.9	-2.0	1.9	2.0	2.0	-1.8	1.4
Pavlov. Cond. response bias	3.8	5.2	6.4	2.5	-2.2	-2.4	-2.4	2.2	2.5	2.5	-2.1	1.7
Time in closed arm before self-admin	0.2	0.2	0.4	-0.5	0.3	0.6	0.5	-0.4	-0.5	-0.5	0.3	-0.1
Time in closed arm after self-admin	0.4	0.4	0.7	-0.8	0.5	0.8	0.7	-0.7	-0.8	-0.8	0.4	-0.1
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	0.5	0.4	0.4	-0.4	-0.4	-0.4	0.2	0.0
Time in open arm after self-admin	0.1	0.1	0.6	0.3	-0.1	-0.4	-0.2	0.2	0.3	0.3	0.3	-0.8
Bone: periosteal estimation	2.4	5.0	5.6	2.3	-2.4	-2.3	-2.4	2.3	2.3	2.3	-2.1	1.7
Bone: periosteal perimeter	3.3	5.5	6.3	2.5	-2.5	-2.5	-2.5	2.5	2.4	2.4	-2.1	1.5
Bone: post-yield work	0.7	0.9	1.1	-0.9	1.0	0.9	1.0	-1.1	-0.9	-0.9	1.1	-0.8
Progressive ratio test 1 active lever presses	3.0	3.1	3.7	1.7	-1.8	-1.8	-1.8	1.9	1.7	1.6	-1.8	1.6
Progressive ratio test 1 breakpoint	3.7	3.9	4.6	1.9	-2.0	-2.1	-2.0	2.2	1.9	1.9	-2.0	1.8
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4	0.4	0.5	0.5	-0.1	-0.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.4	-0.6	-0.7	-0.5	0.7	0.4	0.4	-0.3	-0.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.4	-0.6	-0.6	-0.5	0.7	0.4	0.3	-0.4	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	1.0	0.4	-0.2	-0.2	-0.2	0.3	0.3	0.3	0.3	-1.0
Incentive Sensitization - Responses	0.3	0.3	0.6	0.4	-0.8	-0.8	-0.6	0.7	0.4	0.3	-0.5	0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.3	0.2	-0.6	-0.6	-0.4	0.6	0.2	0.1	-0.3	0.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.2	1.1	-0.8	-1.0	-1.0	0.9	1.1	1.1	-0.8	0.5
Progressive ratio	2.6	3.1	3.9	-1.9	2.0	1.8	1.9	-1.9	-1.8	-1.8	1.5	-1.0
Food seeking constrained by brief footshock	0.1	0.2	0.4	0.7	-0.3	-0.2	-0.4	0.5	0.5	0.5	-0.1	-0.3
Seeking ratio, punishment vs. effort	2.5	3.0	4.1	2.0	-1.9	-1.7	-1.9	1.9	1.8	1.8	-1.4	0.6
Retroperitoneal fat weight	0.0	0.1	0.2	-0.0	-0.5	-0.1	-0.1	0.3	-0.1	-0.2	-0.3	0.3
Reaction time number correct	0.2	0.2	0.5	0.7	-0.3	-0.3	-0.4	0.3	0.6	0.7	-0.0	-0.5
Reaction time mean minus median	0.9	1.1	1.4	-1.1	1.2	1.1	1.1	-1.1	-1.0	-1.0	1.1	-1.0
Reaction time mean minus median AUC	0.7	0.9	1.2	-0.9	1.1	1.0	1.0	-0.9	-0.8	-0.8	0.9	-0.9
Reaction time num false alarms	1.8	2.4	3.3	1.7	-1.7	-1.5	-1.6	1.8	1.6	1.6	-1.5	0.9
Reaction time num false alarms AUC	2.0	2.8	3.6	1.7	-1.8	-1.5	-1.7	1.9	1.7	1.7	-1.7	1.3
Reaction time trials correct on left	0.2	0.2	0.5	0.7	-0.3	-0.3	-0.4	0.3	0.6	0.7	-0.0	-0.5
Reaction time trials on left	0.2	0.3	0.6	0.8	-0.3	-0.4	-0.5	0.4	0.7	0.7	-0.1	-0.4
Reaction time mean	0.0	0.0	0.1	-0.2	0.3	-0.0	0.1	-0.1	-0.1	-0.1	-0.0	0.3
Reaction time mean AUC	0.0	0.0	0.1	-0.2	0.3	0.1	0.2	-0.2	-0.2	-0.2	0.1	0.1
Median of all reaction times	0.0	0.1	0.2	0.1	-0.0	-0.3	-0.2	0.2	0.2	0.2	-0.3	0.5
Reaction time omissions	0.2	0.3	0.5	0.7	-0.4	-0.5	-0.5	0.6	0.7	0.7	-0.4	0.1
Reaction time false alarm rate	1.2	1.6	2.1	1.2	-1.4	-1.2	-1.3	1.5	1.2	1.1	-1.4	1.2
Reaction time premature initiation rate	0.2	0.3	0.6	-0.5	0.8	0.6	0.5	-0.5	-0.4	-0.4	0.3	-0.1
Reaction time premature initiations	0.1	0.2	0.5	-0.2	0.7	0.6	0.4	-0.4	-0.2	-0.2	0.4	-0.4
Std. dev. reaction times	0.1	0.2	0.6	0.3	-0.1	-0.3	-0.3	0.3	0.3	0.4	-0.5	0.8
Reaction time trials completed	0.2	0.3	0.6	0.8	-0.3	-0.4	-0.5	0.4	0.7	0.7	-0.1	-0.4
Reaction time trials AUC	0.2	0.3	0.6	0.8	-0.4	-0.4	-0.5	0.4	0.8	0.8	-0.1	-0.4
Run reversals in cocaine runway, females	0.1	0.1	0.6	0.1	0.3	0.2	0.2	-0.2	-0.0	-0.0	0.4	-0.8
Run reversals in cocaine runway, males	0.9	0.9	1.2	1.0	-1.1	-1.0	-1.0	0.9	0.9	0.9	-0.8	0.5
Latency to leave start box in cocaine runway	0.4	0.4	0.7	-0.8	0.6	0.7	0.6	-0.6	-0.8	-0.8	0.5	-0.2
Latency to leave start box in cocaine runway, F	1.1	1.2	1.6	-1.3	1.1	1.0	1.1	-1.0	-1.2	-1.3	1.0	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.3	0.3	0.3	-0.2	0.1
Std. dev. time between licks in bursts	0.5	0.6	0.8	0.8	-0.8	-0.8	-0.8	0.9	0.7	0.7	-0.8	0.5
Total sessions with >9 infusions	0.6	0.7	1.3	0.6	-0.7	-0.9	-0.8	0.9	0.7	0.7	-1.0	1.1
Short access day 1 total inactive lever presses	0.6	0.7	0.8	-0.9	0.9	0.9	0.9	-0.9	-0.9	-0.9	0.8	-0.6
Short access day 10 total inactive lever presses	4.6	5.1	9.0	-1.9	2.1	2.1	2.2	-2.1	-2.1	-2.1	2.6	-3.0
Short access day 1 total infusions	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.3	0.1	0.1	-0.3	0.3
Short access day 10 total infusions	0.1	0.1	0.4	-0.0	-0.2	-0.3	-0.2	0.3	0.1	0.1	-0.4	0.6
Short access total infusions	0.4	0.5	0.7	0.5	-0.7	-0.8	-0.7	0.8	0.6	0.6	-0.8	0.8
Short access day 1 locomotion	1.1	1.2	2.5	-1.0	1.0	0.9	1.0	-0.9	-1.0	-1.0	1.3	-1.6
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	-0.0	0.1	0.1	0.0	-0.0
Short access total locomotion	0.0	0.0	0.3	0.1	0.1	0.0	0.1	-0.1	0.1	0.0	0.3	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.4	-0.2	0.1	0.1	0.2	-0.1	-0.2	-0.2	0.4	-0.6
Compulsive drug intake	4.0	4.1	4.6	-2.1	2.1	2.1	2.1	-2.1	-2.1	-2.1	1.9	-1.4
One hour access (shock baseline)	0.3	0.4	0.5	0.7	-0.7	-0.7	-0.6	0.7	0.7	0.6	-0.4	0.0
Social response proportion	1.2	1.3	1.9	1.4	-1.3	-1.3	-1.2	1.0	1.3	1.3	-0.6	-0.1
Social responses	4.5	5.8	6.7	2.6	-2.5	-2.5	-2.5	2.4	2.6	2.6	-2.2	1.6
Social time	0.5	0.6	0.8	0.8	-0.7	-0.9	-0.8	0.6	0.8	0.8	-0.8	0.8
Soleus weight	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.2	0.2	0.2	0.1	-0.2
Bone: stiffness	1.9	3.1	3.6	1.8	-1.9	-1.8	-1.8	1.8	1.7	1.7	-1.7	1.4
Tibialis anterior weight	0.8	2.7	3.0	1.7	-1.7	-1.7	-1.7	1.7	1.7	1.7	-1.6	1.4
Time to tail flick, vehicle, before self-admin	2.3	2.4	3.1	-1.4	1.5	1.5	1.5	-1.5	-1.4	-1.4	1.7	-1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.0	-0.1	0.1	0.0	0.0	-0.0	0.0	-0.1	0.3
Time to tail flick, test, before self-admin	1.2	1.1	1.7	1.1	-1.0	-0.9	-1.0	0.9	1.0	1.1	-1.2	1.3
Time to tail flick, test, after self-admin	2.6	2.7	3.6	-1.5	1.5	1.6	1.6	-1.6	-1.6	-1.6	1.8	-1.9
Delta time to tail flick, vehicle, before/after SA	3.8	3.8	4.4	2.0	-2.1	-1.8	-1.9	2.0	1.9	1.9	-2.0	1.9
Delta time to tail flick, test, before/after SA	3.9	3.5	5.9	-1.6	1.8	1.7	1.8	-1.8	-1.6	-1.6	2.2	-2.4
Tibia length	4.7	13.4	14.1	3.7	-3.7	-3.8	-3.7	3.7	3.7	3.7	-3.6	3.4
Ambulatory time before self-admin	4.2	4.4	6.0	2.2	-2.0	-2.5	-2.2	2.3	2.2	2.1	-1.8	1.4
Ambulatory time after self-admin	3.7	4.1	6.2	2.0	-2.0	-2.5	-2.1	2.2	2.1	2.0	-1.8	1.2
Bone: tissue strength	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.4	0.3	0.4	0.4	-0.3	0.3
Total heroin consumption	3.4	4.0	4.5	2.1	-1.9	-2.1	-2.0	2.0	2.1	2.1	-2.0	1.7
Bone: trabecular number	0.6	0.9	1.2	1.1	-1.1	-1.1	-1.0	1.0	1.0	1.0	-0.7	0.4
Bone: trabecular spacing	0.1	0.1	0.2	-0.4	0.4	0.4	0.3	-0.4	-0.4	-0.3	0.2	-0.0
Bone: trabecular thickness	0.3	0.4	0.6	0.7	-0.7	-0.6	-0.7	0.7	0.7	0.7	-0.5	0.1
Bone: trabecular tissue density	1.5	2.1	2.6	1.5	-1.6	-1.5	-1.5	1.6	1.4	1.4	-1.3	0.9
Water consumed over 24 hours	0.1	0.1	0.3	-0.3	0.4	0.3	0.5	-0.5	-0.3	-0.3	0.5	-0.3
Number of responses in last shaping day	0.3	0.3	0.6	-0.4	0.5	0.6	0.5	-0.6	-0.5	-0.4	0.6	-0.8