Hub : Genes

LOC103690230

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	isoform ratio	XM_039080463.1	0.75	0.11	5.8e-03	0.11	0	0.18	0.14	1.2e-03	2.6e-01	4.7e-05	3.4e-04
2	OFC	gene expression	LOC103690230	0.86	0.09	9.0e-04	-0.01	-0.01	-0.01	0.01	8.1e-01	6.4e-01	9.1e-01	1.5e-01
3	NAcc	gene expression	LOC103690230	0.33	0.16	3.7e-03	0.01	0	-0	0	2.8e-02	1.4e-01	4.8e-01	1.3e-01
4	Brain	isoform ratio	XM_039080463.1	0.09	0.07	7.1e-09	0.07	0.09	0.09	0.07	2.1e-07	1.5e-08	1.8e-08	2.3e-07
5	RMTg	isoform ratio	XM_039080463.1	0.14	0.14	4.2e-03	0.13	0.07	0.09	0.05	2.5e-04	5.9e-03	2.4e-03	1.8e-02
6	IL	gene expression	LOC103690230	0.54	0.23	8.3e-04	0	-0.01	-0.01	0.05	3.2e-01	7.1e-01	7.0e-01	2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.3	0.5	-0.5	0.4	-0.1	-0.3	-0.5
Area under the delay curve	0.7	0.7	2.3	-0.4	0.9	-0.7	0.8	-0.0	1.5
BMI with tail	0.1	0.2	0.5	0.4	-0.4	0.4	-0.5	0.7	-0.4
BMI without tail	0.2	0.5	1.6	-0.0	-0.2	0.2	-1.1	1.3	-0.0
Body weight	0.4	1.6	2.0	1.1	-1.3	1.2	-1.4	1.3	-1.3
Weight adjusted by age	0.3	0.3	0.7	-0.4	0.5	-0.5	0.8	-0.4	0.4
Bone surface	2.3	4.0	4.9	1.8	-2.1	2.0	-2.2	1.9	-2.0
Bone volume	1.2	2.1	3.0	1.3	-1.4	1.4	-1.7	1.4	-1.5
Breakpoint value in progressive ratio session	0.2	0.3	0.9	-0.3	0.4	-0.4	0.4	-1.0	0.3
Number of licking bursts	1.5	1.7	3.1	1.1	-1.1	1.1	-1.8	1.8	-0.7
Context. condit. distance diff. score	0.2	0.2	0.8	0.0	0.1	-0.1	0.9	-0.6	0.4
Locomotion velocity, session 1	0.3	0.3	0.4	-0.6	0.6	-0.6	-0.4	0.6	0.4
Locomotion distance, session 1	0.5	0.6	1.1	-1.1	0.9	-0.9	-0.6	0.4	0.7
Locomotion velocity, session 2	1.6	1.9	2.8	-1.6	1.7	-1.7	0.8	-0.7	1.4
Locomotion distance, session 2	1.2	1.7	3.5	-1.9	1.6	-1.6	-0.6	0.3	1.2
Locomotion velocity, session 3	1.5	1.7	3.0	0.9	-1.2	1.1	-1.7	1.6	-1.1
Locomotion distance, session 3	4.8	5.3	6.8	2.1	-2.3	2.2	-2.6	2.3	-2.3
Stereotopy head waving bouts, day 3	0.7	0.8	1.1	-1.0	1.0	-0.9	0.7	-0.5	1.1
Stereotopy head waving duration, day 3	4.0	4.8	5.5	-2.1	2.2	-2.1	2.3	-1.9	2.4
Locomotion velocity, session 7	1.8	2.0	2.9	-1.2	1.3	-1.3	1.7	-1.5	1.4
Locomotion distance, session 7	0.7	0.9	1.3	-0.9	0.9	-0.9	1.1	-1.0	0.9
Stereotopy head waving bouts, day 7	0.1	0.2	0.4	-0.0	0.2	-0.1	0.6	-0.7	0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.1	0.1	-0.0	0.7	-0.8	0.2
Locomotion velocity, session 8	1.1	1.3	1.5	-1.0	1.1	-1.1	1.2	-1.2	1.1
Locomotion distance, session 8	0.9	1.3	2.0	-1.4	1.3	-1.3	0.5	-0.5	1.3
Degree of sensitization distance	10.5	10.5	13.1	-3.0	3.3	-3.1	3.6	-3.2	3.2
Degree of sensitization stereotypy	0.1	0.1	0.2	0.2	-0.1	0.1	0.3	-0.4	-0.1
Conditioned locomotion	0.7	0.9	1.1	0.9	-1.0	0.9	-0.9	0.8	-1.0
Cocaine response after cond. corrected	2.8	3.2	4.0	-2.0	2.0	-2.0	1.3	-1.5	1.8
Cocaine response after cond. not corrected	2.7	3.0	3.9	-2.0	1.9	-1.9	1.2	-1.3	1.9
Cocaine response before conditioning	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.2	0.2	0.3
Saline control response	0.1	0.2	0.3	-0.6	0.5	-0.4	-0.0	0.1	0.6
Bone: connectivity density	0.2	0.3	0.4	0.6	-0.6	0.6	-0.4	0.2	-0.6
Bone: cortical apparent density	1.4	1.8	2.2	-1.4	1.5	-1.4	1.2	-1.0	1.5
Bone: cortical area	1.6	2.4	2.9	1.6	-1.7	1.6	-1.5	1.3	-1.7
Bone: cortical porosity	3.2	3.5	4.8	2.2	-2.2	2.1	-1.2	1.1	-2.1
Bone: cortical porosity	1.8	2.0	2.9	1.7	-1.7	1.6	-0.8	0.7	-1.6
Bone: cortical thickness	0.6	0.9	1.4	1.2	-1.1	1.1	-0.7	0.5	-1.1
Bone: cortical thickness	1.7	1.9	2.4	1.5	-1.5	1.5	-1.2	1.0	-1.6
Bone: cortical tissue density	1.4	1.8	2.2	-1.4	1.5	-1.4	1.2	-0.9	1.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.3	-0.3	0.3	0.0	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.6	0.5	0.1	-0.3	-0.5
Condit. Reinf. active responses	0.1	0.1	0.7	0.2	-0.1	0.0	0.4	-0.8	-0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	0.2	-0.2	0.0	-0.3	0.1
Incentive salience index mean	0.4	0.5	0.9	0.8	-0.8	0.7	-0.3	-0.3	-1.0
Condit. Reinf. lever presses	0.5	0.7	1.1	1.0	-0.9	0.9	-0.4	0.2	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.3	0.3	-0.5	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.6	-0.8	0.7	-0.7	0.4	-0.7	0.7
Condit. Reinf. active responses	0.3	0.4	0.5	0.6	-0.7	0.6	-0.7	0.5	-0.6
Condit. Reinf. inactive responses	0.7	0.9	1.2	1.1	-1.1	1.0	-0.7	0.7	-1.1
Condit. Reinf. lever presses	0.7	0.9	1.2	1.0	-1.1	1.1	-0.9	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.5	-0.5	0.5	-0.4	0.2	-0.5
Conditioned reinforcement - actives	0.5	0.5	1.1	0.4	0.3	-0.2	0.9	-1.0	0.8
Conditioned reinforcement - inactives	1.1	1.2	2.5	1.6	-1.1	1.1	-0.9	0.8	-0.9
Conditioned locomotion	0.3	0.3	0.8	0.9	-0.6	0.6	-0.2	0.2	-0.6
Patch foraging indifference point 0 sec	7.7	12.4	16.7	4.1	-3.9	3.9	-3.4	3.1	-2.5
Patch foraging indifference point AUC	0.3	0.3	0.8	-0.2	-0.2	0.1	-0.9	0.9	-0.6
Delay disc. indifference point, 0s delay	1.1	1.2	1.9	-1.3	1.2	-1.1	0.9	-0.4	1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.0	0.1	-0.1	0.1	0.5	0.6
Delay disc. indifference point, 2s delay	1.4	1.5	3.5	-1.1	1.3	-1.2	1.1	-0.4	1.9
Delay disc. indifference point, 24s delay	1.6	1.6	3.6	-0.8	1.2	-1.1	1.3	-0.9	1.9
Delay disc. indifference point, 4s delay	0.5	0.5	1.8	-0.0	0.6	-0.5	0.7	-0.1	1.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.0	0.3	-0.2	0.2	0.4	0.5
Indifference point function ln k	0.5	0.7	1.5	1.2	-1.0	1.0	-0.5	0.1	-0.7
Indifference point function log k	0.5	0.7	1.5	1.2	-1.0	1.0	-0.5	0.1	-0.7
Patch foraging total patch changes 0 sec	7.8	12.5	17.6	4.2	-3.9	4.0	-3.4	3.1	-2.4
Patch foraging total patch changes 12 sec	1.7	2.3	4.3	1.0	-1.3	1.3	-2.1	1.8	-1.3
Patch foraging total patch changes 18 sec	1.1	1.4	3.8	0.1	-0.6	0.5	-1.8	2.0	-0.8
Patch foraging total patch changes 24 sec	0.9	1.1	1.8	1.0	-1.0	1.2	-1.2	1.3	-0.2
Patch foraging total patch changes 6 sec	4.1	6.1	9.3	1.9	-2.3	2.2	-3.1	3.0	-2.2
Patch foraging time to switch 0 sec	0.0	0.1	0.3	-0.2	0.1	-0.1	0.1	-0.6	0.1
Patch foraging water rate 0 sec	0.7	1.1	1.5	1.2	-1.1	1.1	-1.0	1.2	-0.5
Patch foraging water rate 12 sec	0.9	1.4	4.0	2.0	-1.3	1.4	-0.3	0.6	-0.4
Patch foraging water rate 18 sec	0.2	0.3	1.1	-0.1	0.4	-0.3	0.3	-0.1	1.0
Patch foraging water rate 24 sec	0.2	0.3	0.8	-0.5	0.2	-0.3	-0.6	0.9	-0.2
Patch foraging water rate 6 sec	0.1	0.2	0.5	-0.2	-0.1	0.1	-0.7	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2	0.4	-0.2
Distance traveled before self-admin	1.4	1.5	3.6	-0.6	0.8	-0.7	1.5	-1.9	1.3
Distance traveled after self-admin	0.2	0.3	0.5	-0.6	0.7	-0.7	0.4	-0.3	0.3
Extensor digitorum longus weight	0.7	2.9	4.5	-1.3	1.6	-1.5	2.0	-2.1	1.5
Bone: elastic displacement	0.0	0.0	0.1	0.0	0.0	-0.0	0.2	-0.2	0.0
Bone: elastic work	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	-0.0	0.1
Bone: endosteal estimation	0.9	2.0	2.5	1.2	-1.4	1.3	-1.6	1.5	-1.4
Bone: endosteal perimeter	0.6	1.2	1.4	1.1	-1.1	1.1	-1.1	1.0	-1.2
Epididymis fat weight	1.0	2.3	4.7	0.9	-1.1	1.1	-2.0	2.2	-1.3
Delta time in closed arm before/after self-admin	1.4	1.3	1.6	-1.2	1.2	-1.1	1.0	-1.1	1.2
Delta time in open arm before/after self-admin	0.6	0.6	0.9	0.8	-0.8	0.7	-0.6	0.9	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	0.2	-0.1
Delay discount exponential model param	0.7	0.7	2.4	0.3	-0.8	0.7	-0.9	0.1	-1.5
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.3	-0.2	0.3	-0.3	0.2	0.0
Active lever presses in extinction session 6	0.8	0.8	1.9	-1.4	1.0	-1.0	0.0	-0.7	0.6
Bone: final force	1.9	3.1	4.2	1.5	-1.7	1.6	-2.0	1.8	-1.8
Bone: final moment	2.1	3.3	4.3	1.6	-1.8	1.7	-2.1	1.9	-1.9
Food consumed during 24 hour testing period	0.2	0.2	0.7	0.8	-0.4	0.5	0.1	-0.2	0.2
Glucose	1.3	2.0	3.4	-1.1	1.3	-1.3	1.5	-1.9	1.1
Heart weight	0.1	0.1	0.3	-0.3	0.4	-0.4	0.6	-0.1	0.3
Delay discount hyperbolic model param	0.6	0.7	2.2	0.3	-0.8	0.7	-0.8	0.0	-1.5
Intermittent access intake day 1-15 change	1.0	1.0	1.5	1.2	-1.1	1.1	-0.5	0.3	-1.2
Intermittent access intake escalation	1.7	1.7	2.7	1.5	-1.5	1.4	-0.8	0.6	-1.7
Intermittent access intake escalation 2	1.0	1.0	1.6	1.3	-1.2	1.2	-0.7	0.2	-1.0
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.6	-0.8	0.7	-0.7	0.5	0.1	0.1
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.6	0.9	-0.6	0.6	-0.7	1.3	-0.9
Intermitt. access escalation Index	0.2	0.2	0.4	-0.6	0.5	-0.5	0.3	0.1	0.4
Intermittent access day 1 total infusions	0.2	0.2	1.1	0.3	0.1	-0.1	-0.4	1.1	-0.2
Intermittent access day 15 total infusions	1.2	1.3	1.9	1.4	-1.0	0.9	-0.9	1.3	-1.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.7	0.1	-0.1	0.4	-0.0	0.2
Intermittent access total infusions	0.3	0.3	0.7	0.9	-0.3	0.3	-0.3	0.8	-0.5
Intermittent access day 1 locomotion	1.0	1.0	2.6	0.8	-0.7	0.6	-1.1	1.6	-1.0
Intermittent access day 15 total locomotion	2.3	2.5	3.5	1.7	-1.6	1.5	-1.4	1.3	-1.9
Intermittent access total locomotion	1.5	1.7	2.3	1.5	-1.2	1.2	-1.1	1.2	-1.5
Intermittent access standard deviation	0.0	0.0	0.2	0.2	0.1	-0.1	0.1	0.4	-0.0
Left kidney weight	0.2	0.5	1.3	-0.9	0.7	-0.7	0.3	-0.2	1.2
Right kidney weight	0.1	0.2	0.7	0.2	-0.5	0.5	-0.8	0.4	-0.0
Cocaine induced anxiety	0.1	0.1	0.3	0.2	0.0	0.1	0.1	0.1	0.5
Post-drug Anxiety	0.1	0.1	0.2	-0.3	0.3	-0.3	0.5	-0.1	0.5
Baseline Anxiety	0.2	0.2	0.9	0.2	-0.5	0.4	-0.2	0.0	-1.0
Tail length	0.4	1.3	2.6	0.6	-0.8	0.8	-1.6	1.6	-0.9
Length with tail	0.7	2.7	3.5	1.6	-1.7	1.6	-1.7	1.3	-1.9
Length without tail	0.7	1.5	2.4	1.5	-1.4	1.4	-0.4	-0.2	-1.5
Times rat made contact with spout	0.7	0.8	2.1	1.5	-0.8	0.9	0.5	-0.7	0.4
Lifetime Intake	0.1	0.1	0.4	0.6	0.2	-0.2	0.3	0.2	0.1
Liver weight, left	1.2	1.9	2.5	-1.5	1.6	-1.6	1.2	-0.9	1.3
Liver weight, right	0.0	0.1	0.2	0.1	-0.0	-0.1	-0.1	0.4	-0.5
Locomotor activity	6.1	9.7	19.5	4.4	-3.6	3.8	-2.3	2.0	-1.4
Locomotor testing distance	5.3	8.8	16.8	4.1	-3.4	3.6	-2.4	2.0	-1.3
Locomotor testing rearing	2.3	3.5	4.6	2.1	-1.9	2.0	-1.9	2.1	-0.9
Locomotion in novel chamber	0.1	0.1	0.2	-0.1	0.3	-0.3	0.4	0.1	0.3
Locomotion in novel chamber post-restriction	1.9	2.3	3.2	-1.7	1.8	-1.6	1.3	-1.0	1.6
Fecal boli incidents, locomotor time 1	0.6	0.6	1.2	1.1	-0.9	1.0	-0.7	0.3	-0.5
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	-0.8	0.7	-0.8	0.6	-0.6	0.3
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.7	1.2	-1.1	1.1	-0.9	0.8	-1.3
Bouts of movement, locomotor time 1	0.3	0.3	1.6	-0.1	0.3	-0.3	-0.2	1.2	0.1
Total resting periods, locomotor time 1	0.3	0.3	1.6	-0.1	0.2	-0.3	-0.3	1.3	0.0
Rest time, locomotor task time 1	3.4	3.7	4.3	2.0	-1.9	1.9	-1.9	2.1	-1.8
Distance moved, locomotor task time 1	1.9	2.0	3.8	-1.3	1.4	-1.4	1.5	-1.9	0.9
Vertical activity count, locomotor time 1	1.9	2.0	2.9	-1.1	1.4	-1.4	1.5	-1.7	1.1
Time >=10cm from walls, locomotor time 2	1.0	1.0	1.7	-0.6	1.0	-0.9	1.3	-1.2	1.0
Bouts of movement, locomotor time 2	4.5	4.8	8.0	-2.8	2.5	-2.5	1.6	-0.6	2.4
Total resting periods, locomotor time 2	3.7	3.9	6.9	-2.6	2.3	-2.2	1.4	-0.4	2.1
Rest time, locomotor task time 2	1.7	1.9	2.2	1.5	-1.4	1.4	-1.4	1.4	-1.1
Distance moved, locomotor task time 2	1.6	1.8	2.8	-1.3	1.3	-1.4	1.5	-1.7	0.7
Vertical activity count, locomotor time 2	0.9	1.0	1.3	-1.0	1.1	-1.1	1.1	-1.0	0.7
Light reinforcement 1	1.2	2.2	2.9	1.6	-1.7	1.7	-1.7	1.0	-1.0
Light reinforcement 2	0.4	0.5	0.9	1.0	-0.8	0.8	-0.6	0.4	-0.7
Bone: marrow area	0.9	1.9	2.4	1.2	-1.4	1.3	-1.5	1.5	-1.4
Bone: maximum diameter	0.7	1.3	1.4	1.1	-1.2	1.1	-1.1	1.0	-1.2
Bone: maximum force	2.7	4.6	5.9	1.9	-2.1	2.0	-2.4	2.3	-2.1
Bone: maximum moment	2.8	4.8	5.9	2.0	-2.2	2.1	-2.4	2.4	-2.2
Mean time between licks in bursts	0.5	0.7	2.2	1.5	-0.9	1.1	0.1	-0.2	0.1
Mean num. licks in bursts	1.1	1.3	3.1	-0.3	0.7	-0.6	1.7	-1.8	0.8
Cd content in liver	5.1	5.6	12.1	3.5	-3.1	2.9	-1.1	1.3	-1.0
Co content in liver	5.1	6.0	13.9	3.7	-3.2	3.0	-1.1	1.2	-0.5
Cu content in liver	1.8	2.2	3.8	2.0	-1.8	1.7	-1.1	1.2	-0.6
Fe content in liver	0.1	0.1	0.4	0.6	-0.5	0.4	-0.0	-0.0	0.0
K content in liver	6.9	6.8	9.1	2.9	-3.0	2.8	-2.6	2.3	-1.8
Mg content in liver	3.1	3.2	4.7	2.2	-2.2	2.0	-1.6	1.5	-1.0
Mn content in liver	0.4	0.4	1.1	-0.2	-0.1	0.1	-1.1	0.9	-0.7
Na content in liver	0.4	0.4	0.7	-0.8	0.7	-0.7	0.5	-0.8	0.1
Rb content in liver	0.5	0.6	1.6	1.3	-1.0	0.9	-0.1	0.0	0.1
Se content in liver	14.4	17.6	38.1	6.2	-5.3	5.1	-2.5	2.4	-1.1
Sr content in liver	2.6	2.4	2.6	1.4	-1.6	1.5	-1.6	1.6	-1.5
Zn content in liver	1.3	1.5	2.0	1.4	-1.4	1.3	-1.0	1.3	-0.8
Bone: minimum diameter	1.3	2.5	3.6	1.3	-1.5	1.4	-1.9	1.7	-1.6
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.2	-0.2	0.1	0.2	-0.5	-0.2
Time in novel zone, hab. session 1	1.4	1.3	1.8	-1.1	1.2	-1.1	1.2	-1.0	1.3
Total zone transitions, hab. session 1	0.3	0.4	1.3	-0.6	0.3	-0.3	-1.2	0.8	0.2
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.6	0.4	-0.5	-0.4	0.0	0.3
Locomotion velocity, hab. session 1	0.4	0.5	1.6	0.0	-0.2	0.2	-1.3	1.0	-0.4
Time in familiar zone, hab. session 2	1.1	1.1	1.9	-1.2	1.2	-1.1	0.6	-0.1	1.4
Time in novel zone, hab. session 2	0.7	0.7	1.2	1.0	-1.0	0.9	-0.4	0.1	-1.1
Total zone transitions, hab. session 2	0.6	0.8	1.6	-1.3	1.1	-1.1	-0.2	0.1	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.3	0.2	-0.2	-0.6	0.3	0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.4	0.2	-0.3	-0.6	0.3	0.1
Novel to familiar place preference ratio	0.0	0.0	0.1	0.3	-0.2	0.2	-0.2	0.1	-0.3
Novelty place preference	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.0
Time in novel zone, NPP test	0.2	0.2	0.3	-0.4	0.5	-0.5	0.4	-0.4	0.4
Total zone transitions, NPP test	0.7	1.0	1.9	-1.4	1.3	-1.3	0.0	-0.2	0.9
Total locomotion distance, NPP test	0.8	1.1	1.8	-1.3	1.3	-1.3	0.3	-0.6	1.0
Locomotion velocity, NPP test	0.2	0.2	0.5	-0.7	0.6	-0.6	-0.5	0.2	0.3
Intraocular pressure	0.2	0.3	0.5	-0.5	0.3	-0.3	0.6	-0.7	0.6
Delta distance traveled before/after self-admin	1.1	1.2	3.0	0.5	-0.6	0.5	-1.3	1.7	-1.2
Delta ambulatory time before/after self-admin	0.7	0.7	1.8	-0.0	-0.3	0.2	-1.2	1.3	-1.0
Parametrial fat weight	0.9	1.7	2.4	1.5	-1.5	1.5	-0.9	0.6	-1.5
Pavlov. Cond. lever latency	3.7	4.6	5.0	-2.0	2.2	-2.1	2.2	-2.2	2.2
Pavlov. Cond. magazine entry latency	0.9	1.1	1.5	1.2	-1.2	1.2	-0.7	0.9	-1.2
Pavlov. Cond. change in total contacts	0.6	0.6	0.9	0.9	-0.9	0.9	-0.5	0.4	-0.9
Pavlov. Cond. index score	2.0	2.6	3.1	1.7	-1.7	1.7	-1.3	1.4	-1.8
Pavlov. Cond. latency score	2.8	3.6	4.3	2.0	-2.0	1.9	-1.7	1.7	-2.1
Pavlov. Cond. lever contacts	3.2	3.8	4.3	1.8	-2.0	1.9	-2.1	2.0	-1.9
Pavlov. Cond. magazine entry number	1.8	2.3	2.6	-1.6	1.6	-1.6	1.2	-1.4	1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.2	0.3	-0.3	0.4	-0.6	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	2.9	1.7	-1.7	1.6	-1.1	1.3	-1.7
Pavlov. Cond. response bias	2.2	2.7	3.0	1.7	-1.7	1.7	-1.4	1.7	-1.7
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.7	0.7	-0.7	0.2	-0.1	0.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.6	-0.5	0.5	0.2	-0.0	-0.5
Pavlov. Cond. change in total contacts	0.5	0.7	1.4	1.2	-1.0	1.0	-0.0	-0.3	-1.0
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	-0.3	0.3	0.2	-0.2	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	-0.3	0.3	0.3	-0.3	-0.3
Pavlov. Cond. lever contacts	0.4	0.5	0.7	0.9	-0.9	0.8	-0.5	0.4	-0.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.3	0.1	-0.1	-0.7	0.7	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.5	0.4	-0.3	-0.2	0.2	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	-0.3	0.3	0.2	-0.2	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.5	-0.4	0.4	-0.0	-0.0	-0.4
Time in closed arm before self-admin	0.5	0.6	1.0	1.0	-0.8	0.8	-0.5	0.9	-0.5
Time in closed arm after self-admin	0.2	0.2	0.3	0.5	-0.6	0.6	-0.5	0.1	-0.4
Time in open arm before self-admin	0.5	0.5	1.4	-1.2	0.7	-0.8	0.1	-0.7	0.2
Time in open arm after self-admin	0.1	0.1	0.4	0.1	-0.2	0.1	-0.4	0.5	-0.6
Bone: periosteal estimation	1.6	3.3	3.6	1.7	-1.9	1.8	-1.9	1.7	-1.9
Bone: periosteal perimeter	0.7	1.2	1.4	1.0	-1.1	1.1	-1.2	1.0	-1.2
Bone: post-yield work	3.0	4.1	6.2	1.6	-1.9	1.8	-2.4	2.5	-1.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.1	0.0	-0.1	-0.3	0.5	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.3	0.5	-0.6	0.1	0.3	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	-0.3	0.6	-0.7	0.5	0.2	0.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.6	0.8	-0.5	0.5	-0.6	0.6	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.5	-0.3	0.3	-0.6	0.6	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	0.2	-0.2	0.3	0.3	-0.0
Incentive Sensitization - Responses	0.5	0.5	0.5	0.6	-0.7	0.7	-0.7	0.6	-0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.4	-0.5	0.5	-0.5	0.4	-0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	0.8	-0.7	0.8	-0.6	0.3	-0.4
Progressive ratio	1.0	1.1	1.8	-0.6	1.0	-0.9	1.2	-1.4	1.2
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1	-0.3	-0.1
Seeking ratio, punishment vs. effort	0.9	1.1	1.5	0.6	-1.1	0.9	-1.1	1.2	-1.2
Retroperitoneal fat weight	0.1	0.4	0.9	0.6	-0.6	0.5	-0.7	0.3	-0.9
Reaction time number correct	1.1	1.6	3.8	2.0	-1.6	1.7	-0.5	-0.2	-0.3
Reaction time mean minus median	1.9	2.6	3.2	-1.7	1.8	-1.8	1.6	-1.3	1.4
Reaction time mean minus median AUC	1.4	1.8	2.2	-1.3	1.5	-1.4	1.4	-1.0	1.5
Reaction time num false alarms	0.6	0.8	2.3	0.7	-0.6	0.7	-1.1	1.5	0.0
Reaction time num false alarms AUC	0.7	0.9	2.1	0.9	-0.7	0.9	-1.1	1.5	0.4
Reaction time trials correct on left	1.1	1.6	3.8	2.0	-1.6	1.7	-0.5	-0.2	-0.3
Reaction time trials on left	1.1	1.6	3.8	1.9	-1.6	1.7	-0.5	-0.2	-0.3
Reaction time mean	0.9	1.2	1.7	-1.1	1.1	-1.2	1.3	-1.0	0.8
Reaction time mean AUC	0.7	1.0	1.6	-1.0	1.0	-1.0	1.3	-0.9	0.7
Median of all reaction times	0.2	0.3	0.7	-0.5	0.5	-0.5	0.9	-0.6	0.3
Reaction time omissions	0.3	0.4	0.7	-0.8	0.7	-0.7	0.6	-0.4	0.7
Reaction time false alarm rate	0.3	0.4	1.6	-0.3	0.3	-0.3	-0.5	1.3	0.6
Reaction time premature initiation rate	1.1	1.4	1.7	1.3	-1.2	1.1	-1.3	1.1	-1.3
Reaction time premature initiations	2.0	2.8	4.3	2.1	-1.8	1.8	-1.6	1.1	-1.5
Std. dev. reaction times	0.1	0.1	0.4	0.3	0.0	0.1	0.5	-0.1	0.6
Reaction time trials completed	1.1	1.6	3.8	1.9	-1.6	1.7	-0.5	-0.2	-0.3
Reaction time trials AUC	1.0	1.4	3.4	1.8	-1.5	1.6	-0.4	-0.2	-0.3
Run reversals in cocaine runway, females	2.4	2.3	3.2	-1.2	1.6	-1.5	1.6	-1.2	1.8
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.7	0.6	-0.5	0.6	-0.3	0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.5	-0.3	0.2	-0.4	0.7	-0.1
Latency to leave start box in cocaine runway, F	0.5	0.6	0.8	-0.9	0.9	-0.9	0.5	-0.0	0.9
Latency to leave start box in cocaine runway, M	0.9	0.9	1.7	1.3	-1.1	0.9	-0.7	0.7	-0.8
Std. dev. time between licks in bursts	0.5	0.5	1.0	-1.0	0.8	-0.8	-0.4	0.6	0.7
Total sessions with >9 infusions	1.2	1.3	1.8	-0.9	1.3	-1.3	1.2	-0.7	1.2
Short access day 1 total inactive lever presses	0.1	0.1	0.4	0.2	0.2	-0.2	0.1	0.6	-0.2
Short access day 10 total inactive lever presses	1.6	1.7	2.9	1.3	-1.2	1.1	-1.2	1.7	-1.3
Short access day 1 total infusions	1.4	1.5	2.2	-0.5	1.4	-1.4	1.5	-1.0	1.3
Short access day 10 total infusions	0.1	0.1	0.3	0.3	0.1	-0.0	-0.1	0.5	0.2
Short access total infusions	0.6	0.7	1.2	-0.0	0.9	-0.8	1.1	-0.6	1.1
Short access day 1 locomotion	0.4	0.4	1.1	1.0	-0.5	0.5	-0.6	0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.4	-0.6	0.4	-0.4	0.4	-0.4	-0.0
Short access total locomotion	0.0	0.0	0.0	0.1	0.1	-0.1	0.0	0.1	-0.0
One hour access (0.3 mA shock)	0.3	0.3	0.7	0.6	-0.4	0.4	-0.5	0.7	-0.9
Compulsive drug intake	0.1	0.1	0.3	-0.6	0.2	-0.3	0.3	-0.3	-0.0
One hour access (shock baseline)	0.9	1.0	1.9	1.2	-0.8	0.7	-0.8	1.4	-1.1
Social response proportion	0.1	0.1	0.3	-0.4	-0.0	-0.1	-0.5	0.4	-0.5
Social responses	4.5	5.8	7.6	2.8	-2.6	2.7	-2.5	2.0	-1.7
Social time	0.3	0.4	0.8	0.5	-0.5	0.4	-0.6	0.8	-0.9
Soleus weight	0.0	0.1	0.2	0.0	-0.1	0.1	-0.5	0.4	-0.2
Bone: stiffness	2.3	3.7	5.6	1.5	-1.8	1.7	-2.4	2.2	-1.8
Tibialis anterior weight	0.2	0.5	1.8	0.0	0.2	-0.2	1.1	-1.3	0.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.6	-0.5	0.6	-0.4	0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.6	-0.0	0.2	-0.1	0.8	-0.7	0.6
Time to tail flick, test, before self-admin	0.6	0.6	1.6	-1.2	0.9	-1.0	0.1	-0.4	0.3
Time to tail flick, test, after self-admin	0.9	0.9	1.7	-0.8	0.8	-0.7	0.8	-1.3	1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.3	0.3	-0.3	0.7	-0.5	0.4
Delta time to tail flick, test, before/after SA	0.7	0.6	1.5	-0.4	0.5	-0.4	0.9	-1.2	1.0
Tibia length	0.5	1.5	1.7	1.1	-1.3	1.2	-1.3	1.0	-1.3
Ambulatory time before self-admin	1.1	1.2	2.3	-0.2	1.0	-0.9	1.2	-1.5	1.3
Ambulatory time after self-admin	0.2	0.2	0.4	-0.6	0.6	-0.6	0.2	-0.1	0.1
Bone: tissue strength	0.7	0.6	1.0	-1.0	1.0	-0.9	0.3	-0.1	1.0
Total heroin consumption	0.7	0.8	1.5	-0.9	0.6	-0.6	0.8	-1.2	1.1
Bone: trabecular number	0.1	0.1	0.4	0.3	-0.2	0.2	0.4	-0.6	-0.3
Bone: trabecular spacing	0.7	0.9	1.1	-1.0	1.0	-1.0	0.9	-0.7	1.0
Bone: trabecular thickness	1.2	1.4	2.0	1.0	-1.2	1.2	-1.4	1.1	-1.2
Bone: trabecular tissue density	0.3	0.4	0.8	-0.4	0.5	-0.4	0.9	-0.7	0.6
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	0.3	-0.3	0.1	0.0	0.4
Number of responses in last shaping day	0.4	0.4	1.1	1.1	-0.4	0.4	-0.4	0.9	-0.5