Hub : Genes

LOC102556486

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression LOC102556486 0.18 0.12 4.2e-04 0.11 0.1 0.11 0.09 5.9e-04 1.2e-03 7.2e-04 2.2e-03
2 Adipose gene expression LOC102556486 0.02 0.02 2.7e-03 0.02 0.01 0.01 0.01 1.6e-03 7.1e-03 1.4e-02 6.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.50.91.00.91.0
Area under the delay curve0.00.00.00.20.1
BMI with tail8.226.428.1-5.3-5.0
BMI without tail1.73.43.8-1.7-2.0
Body weight1.14.75.2-2.0-2.3
Weight adjusted by age0.10.10.1-0.2-0.4
Bone surface1.62.93.31.61.8
Bone volume1.42.42.61.51.6
Breakpoint value in progressive ratio session1.41.61.61.21.3
Number of licking bursts4.85.76.2-2.5-2.3
Context. condit. distance diff. score0.30.30.3-0.5-0.6
Locomotion velocity, session 10.40.50.80.90.3
Locomotion distance, session 10.60.81.00.81.0
Locomotion velocity, session 23.03.54.32.11.7
Locomotion distance, session 24.15.76.32.32.5
Locomotion velocity, session 35.15.96.72.62.3
Locomotion distance, session 30.00.00.10.20.2
Stereotopy head waving bouts, day 36.17.17.42.62.7
Stereotopy head waving duration, day 33.84.54.52.12.1
Locomotion velocity, session 70.10.10.10.20.4
Locomotion distance, session 70.50.60.9-0.9-0.6
Stereotopy head waving bouts, day 71.61.91.91.41.4
Stereotopy head waving duration, day 71.82.22.51.61.4
Locomotion velocity, session 83.23.84.52.11.8
Locomotion distance, session 80.50.70.80.80.9
Degree of sensitization distance0.80.81.1-1.0-0.7
Degree of sensitization stereotypy0.00.00.00.20.2
Conditioned locomotion1.92.22.3-1.5-1.5
Cocaine response after cond. corrected3.53.94.4-1.8-2.1
Cocaine response after cond. not corrected3.94.34.7-2.0-2.2
Cocaine response before conditioning0.60.80.90.81.0
Saline control response0.40.50.7-0.6-0.8
Bone: connectivity density0.40.60.70.70.8
Bone: cortical apparent density1.11.52.0-1.0-1.4
Bone: cortical area0.20.30.4-0.6-0.4
Bone: cortical porosity0.00.00.10.00.3
Bone: cortical porosity0.00.00.0-0.10.1
Bone: cortical thickness0.91.51.7-1.3-1.1
Bone: cortical thickness1.01.21.3-1.1-1.1
Bone: cortical tissue density0.81.11.5-0.8-1.2
Condit. Reinf. active minus inactive responses1.72.02.11.41.4
Condit. Reinf. active-inactive response ratio0.00.00.10.10.2
Condit. Reinf. active responses3.44.14.42.02.1
Condit. Reinf. inactive responses2.42.93.11.61.8
Incentive salience index mean1.82.22.21.51.5
Condit. Reinf. lever presses1.31.82.01.41.2
Condit. Reinf. active minus inactive responses1.01.21.21.11.1
Condit. Reinf. active-inactive response ratio0.00.00.00.20.0
Condit. Reinf. active responses1.01.31.51.11.2
Condit. Reinf. inactive responses0.50.60.70.70.8
Condit. Reinf. lever presses1.72.22.41.51.5
Condit. Reinf. lever reinforcers received0.50.80.90.80.9
Conditioned reinforcement - actives0.10.10.10.30.3
Conditioned reinforcement - inactives2.02.22.7-1.3-1.7
Conditioned locomotion1.82.22.71.31.6
Patch foraging indifference point 0 sec3.55.76.4-2.5-2.2
Patch foraging indifference point AUC0.30.40.40.60.6
Delay disc. indifference point, 0s delay0.20.20.2-0.4-0.4
Delay disc. indifference point, 16s delay0.30.30.30.60.6
Delay disc. indifference point, 2s delay0.00.10.1-0.3-0.1
Delay disc. indifference point, 24s delay0.20.20.3-0.6-0.3
Delay disc. indifference point, 4s delay0.70.81.00.81.0
Delay disc. indifference point, 8s delay0.10.10.2-0.2-0.5
Indifference point function ln k0.20.20.3-0.4-0.5
Indifference point function log k0.20.20.3-0.4-0.5
Patch foraging total patch changes 0 sec3.76.06.9-2.6-2.3
Patch foraging total patch changes 12 sec3.14.04.5-2.1-1.9
Patch foraging total patch changes 18 sec0.00.10.1-0.3-0.2
Patch foraging total patch changes 24 sec0.40.50.5-0.7-0.6
Patch foraging total patch changes 6 sec2.23.33.8-1.9-1.7
Patch foraging time to switch 0 sec0.00.00.0-0.2-0.1
Patch foraging water rate 0 sec0.91.51.9-1.1-1.4
Patch foraging water rate 12 sec1.42.22.3-1.4-1.5
Patch foraging water rate 18 sec0.40.50.7-0.6-0.8
Patch foraging water rate 24 sec3.44.85.0-2.1-2.2
Patch foraging water rate 6 sec0.00.00.00.1-0.0
Seeking ratio, delayed vs. immediate footshock1.72.02.11.41.4
Distance traveled before self-admin0.80.81.40.51.2
Distance traveled after self-admin0.20.20.40.30.6
Extensor digitorum longus weight5.923.227.1-4.4-5.2
Bone: elastic displacement0.00.00.0-0.10.1
Bone: elastic work0.30.40.7-0.8-0.4
Bone: endosteal estimation0.40.81.0-1.0-0.8
Bone: endosteal perimeter0.30.60.80.60.9
Epididymis fat weight0.00.00.1-0.20.3
Delta time in closed arm before/after self-admin3.33.23.6-1.9-1.7
Delta time in open arm before/after self-admin0.50.50.7-0.6-0.8
Diff in mean of infusions in LGA sessions1.51.71.91.21.4
Delay discount exponential model param0.00.00.0-0.2-0.2
Extinction: sum of active levers before priming1.21.21.51.01.2
Active lever presses in extinction session 61.41.41.71.01.3
Bone: final force1.42.22.7-1.6-1.3
Bone: final moment1.42.22.7-1.6-1.3
Food consumed during 24 hour testing period0.60.81.1-1.1-0.7
Glucose1.82.72.7-1.6-1.7
Heart weight0.10.10.3-0.1-0.5
Delay discount hyperbolic model param0.00.00.00.0-0.0
Intermittent access intake day 1-15 change0.00.00.00.20.2
Intermittent access intake escalation0.20.10.2-0.4-0.4
Intermittent access intake escalation 20.00.00.00.20.1
Intermitt. access day 1 inactive lever presses0.20.20.3-0.4-0.5
Intermitt. access day 15 inactive lever presses0.30.30.50.70.4
Intermitt. access escalation Index0.50.40.50.70.6
Intermittent access day 1 total infusions0.10.20.2-0.3-0.5
Intermittent access day 15 total infusions0.30.30.4-0.5-0.6
Intermittent access terminal intake (last 3 days)0.10.10.1-0.1-0.3
Intermittent access total infusions0.40.40.5-0.6-0.7
Intermittent access day 1 locomotion0.00.00.00.1-0.1
Intermittent access day 15 total locomotion0.30.30.50.70.3
Intermittent access total locomotion0.40.40.60.80.5
Intermittent access standard deviation0.00.00.00.1-0.0
Left kidney weight0.10.20.30.50.2
Right kidney weight0.41.11.51.20.8
Cocaine induced anxiety2.73.13.11.81.8
Post-drug Anxiety1.41.51.51.21.2
Baseline Anxiety0.10.10.1-0.2-0.2
Tail length4.112.413.53.73.4
Length with tail2.07.48.32.92.6
Length without tail0.00.00.00.10.1
Times rat made contact with spout1.51.71.8-1.3-1.3
Lifetime Intake0.70.70.9-0.8-0.9
Liver weight, left2.43.83.9-2.0-1.9
Liver weight, right0.61.01.4-0.8-1.2
Locomotor activity5.38.49.03.02.8
Locomotor testing distance1.82.93.21.81.6
Locomotor testing rearing0.00.00.0-0.0-0.1
Locomotion in novel chamber0.50.60.6-0.8-0.7
Locomotion in novel chamber post-restriction2.63.13.71.61.9
Fecal boli incidents, locomotor time 11.21.31.4-1.2-1.1
Change in fecal boli incidents, locomotor task1.71.61.91.41.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.3-0.3
Bouts of movement, locomotor time 10.30.40.40.70.6
Total resting periods, locomotor time 11.11.31.41.21.1
Rest time, locomotor task time 10.91.01.21.10.9
Distance moved, locomotor task time 10.20.20.3-0.5-0.4
Vertical activity count, locomotor time 11.51.51.7-1.2-1.3
Time >=10cm from walls, locomotor time 21.92.02.2-1.5-1.3
Bouts of movement, locomotor time 20.91.01.21.10.9
Total resting periods, locomotor time 21.01.11.41.20.9
Rest time, locomotor task time 20.30.40.40.70.5
Distance moved, locomotor task time 20.30.40.5-0.7-0.5
Vertical activity count, locomotor time 22.42.62.8-1.5-1.7
Light reinforcement 13.76.76.92.62.6
Light reinforcement 20.81.11.60.81.3
Bone: marrow area0.30.70.9-0.9-0.8
Bone: maximum diameter0.81.51.51.21.2
Bone: maximum force1.72.93.4-1.8-1.5
Bone: maximum moment1.62.83.3-1.8-1.5
Mean time between licks in bursts0.30.40.50.50.7
Mean num. licks in bursts1.11.41.51.21.1
Cd content in liver0.91.01.4-1.2-0.7
Co content in liver0.91.01.41.20.8
Cu content in liver0.40.50.5-0.7-0.7
Fe content in liver1.11.31.4-1.2-1.1
K content in liver0.70.70.90.70.9
Mg content in liver0.60.60.80.70.9
Mn content in liver1.31.52.01.01.4
Na content in liver0.00.00.00.00.1
Rb content in liver0.20.20.2-0.4-0.4
Se content in liver0.00.00.10.20.2
Sr content in liver0.00.00.0-0.0-0.1
Zn content in liver0.60.60.80.90.7
Bone: minimum diameter0.00.00.0-0.2-0.2
Time in familiar zone, hab. session 13.33.04.01.42.0
Time in novel zone, hab. session 11.61.51.9-1.1-1.4
Total zone transitions, hab. session 11.01.41.61.11.3
Total locomotion distance, hab. session 13.34.64.92.12.2
Locomotion velocity, hab. session 13.24.54.52.12.1
Time in familiar zone, hab. session 23.03.13.21.71.8
Time in novel zone, hab. session 23.03.03.2-1.7-1.8
Total zone transitions, hab. session 20.00.00.00.1-0.0
Total locomotion distance, hab. session 21.11.51.81.31.1
Locomotion velocity, hab. session 21.41.92.21.51.2
Novel to familiar place preference ratio1.11.11.3-1.0-1.2
Novelty place preference0.70.70.8-0.7-0.9
Time in novel zone, NPP test1.11.21.3-1.0-1.2
Total zone transitions, NPP test0.00.00.1-0.3-0.1
Total locomotion distance, NPP test0.20.30.40.60.4
Locomotion velocity, NPP test0.50.60.80.90.7
Intraocular pressure0.10.10.10.30.2
Delta distance traveled before/after self-admin0.00.00.00.1-0.1
Delta ambulatory time before/after self-admin0.00.00.00.20.0
Parametrial fat weight0.00.10.2-0.40.2
Pavlov. Cond. lever latency0.60.71.0-1.0-0.6
Pavlov. Cond. magazine entry latency1.21.61.71.31.2
Pavlov. Cond. change in total contacts0.20.20.2-0.4-0.5
Pavlov. Cond. index score0.91.11.41.20.9
Pavlov. Cond. latency score1.21.61.91.41.1
Pavlov. Cond. lever contacts0.50.60.80.90.6
Pavlov. Cond. magazine entry number0.50.60.7-0.8-0.7
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.21.41.21.0
Pavlov. Cond. response bias0.70.80.90.90.9
Pavlov. Cond. lever latency1.62.12.3-1.4-1.5
Pavlov. Cond. magazine entry latency2.52.93.11.61.8
Pavlov. Cond. change in total contacts0.50.60.80.60.9
Pavlov. Cond. index score1.82.32.61.41.6
Pavlov. Cond. latency score2.22.73.11.51.7
Pavlov. Cond. lever contacts1.01.41.51.11.2
Pavlov. Cond. magazine entry number2.22.62.9-1.5-1.7
Pavlov. Cond. intertrial magazine entries0.81.01.7-0.6-1.3
Pavlov. Cond. lever-magazine prob. diff.2.02.52.81.51.7
Pavlov. Cond. response bias1.72.32.41.51.6
Time in closed arm before self-admin0.20.20.40.60.2
Time in closed arm after self-admin0.30.30.3-0.5-0.6
Time in open arm before self-admin0.10.10.1-0.30.1
Time in open arm after self-admin1.61.82.1-1.4-1.2
Bone: periosteal estimation0.30.60.7-0.8-0.7
Bone: periosteal perimeter0.10.20.30.20.5
Bone: post-yield work0.20.30.4-0.3-0.6
Progressive ratio test 1 active lever presses1.31.31.7-1.0-1.3
Progressive ratio test 1 breakpoint1.31.41.6-1.1-1.3
Progressive ratio test 1 inactive lever presses0.00.00.10.2-0.1
Progressive ratio test 2 active lever presses0.30.30.6-0.3-0.7
Progressive ratio test 2 breakpoint0.10.10.10.3-0.2
Progressive ratio test 2 inactive lever presses0.10.10.1-0.1-0.4
Incentive Sensitization - Responses0.20.20.30.60.3
Incentive Sensitization - Breakpoint0.30.30.50.70.4
Sum of active levers in priming session hrs 5-60.10.10.30.10.5
Progressive ratio1.21.41.6-1.1-1.3
Food seeking constrained by brief footshock1.31.62.01.11.4
Seeking ratio, punishment vs. effort2.02.42.81.41.7
Retroperitoneal fat weight2.58.18.7-2.7-3.0
Reaction time number correct2.23.14.2-2.0-1.4
Reaction time mean minus median2.73.64.62.11.6
Reaction time mean minus median AUC3.95.16.02.52.0
Reaction time num false alarms0.50.71.0-0.6-1.0
Reaction time num false alarms AUC0.71.01.4-0.8-1.2
Reaction time trials correct on left2.23.14.2-2.0-1.4
Reaction time trials on left2.13.04.0-2.0-1.4
Reaction time mean2.43.34.22.01.6
Reaction time mean AUC1.41.82.51.61.1
Median of all reaction times1.31.72.21.51.1
Reaction time omissions0.00.00.00.20.1
Reaction time false alarm rate0.10.10.10.3-0.3
Reaction time premature initiation rate0.91.21.61.30.9
Reaction time premature initiations0.00.00.00.10.1
Std. dev. reaction times1.82.53.31.81.3
Reaction time trials completed2.13.04.0-2.0-1.4
Reaction time trials AUC2.53.64.8-2.2-1.5
Run reversals in cocaine runway, females2.32.22.41.41.6
Run reversals in cocaine runway, males2.62.62.61.61.6
Latency to leave start box in cocaine runway0.30.30.30.50.5
Latency to leave start box in cocaine runway, F0.30.30.30.50.6
Latency to leave start box in cocaine runway, M0.00.00.1-0.2-0.2
Std. dev. time between licks in bursts0.70.81.00.81.0
Total sessions with >9 infusions0.00.00.0-0.20.0
Short access day 1 total inactive lever presses0.00.00.00.0-0.1
Short access day 10 total inactive lever presses0.10.20.3-0.2-0.5
Short access day 1 total infusions0.10.10.1-0.1-0.4
Short access day 10 total infusions0.60.70.8-0.8-0.9
Short access total infusions0.50.60.7-0.7-0.9
Short access day 1 locomotion0.20.30.40.60.4
Short access day 10 total locomotion0.70.80.90.90.8
Short access total locomotion0.20.20.30.50.4
One hour access (0.3 mA shock)0.30.40.4-0.6-0.6
Compulsive drug intake0.10.10.1-0.3-0.3
One hour access (shock baseline)0.50.50.6-0.8-0.6
Social response proportion1.51.61.71.31.2
Social responses11.514.814.93.83.9
Social time0.91.11.5-0.9-1.2
Soleus weight5.114.818.5-3.3-4.3
Bone: stiffness3.04.74.7-2.1-2.2
Tibialis anterior weight1.13.74.4-1.7-2.1
Time to tail flick, vehicle, before self-admin3.33.33.71.91.7
Time to tail flick, vehicle, after self-admin0.00.00.00.20.1
Time to tail flick, test, before self-admin2.62.53.41.81.3
Time to tail flick, test, after self-admin0.30.30.50.40.7
Delta time to tail flick, vehicle, before/after SA2.22.22.4-1.5-1.4
Delta time to tail flick, test, before/after SA0.20.20.3-0.60.0
Tibia length1.13.03.31.81.6
Ambulatory time before self-admin0.20.20.40.00.6
Ambulatory time after self-admin0.00.00.10.00.3
Bone: tissue strength4.03.94.6-2.1-1.8
Total heroin consumption2.22.63.51.31.9
Bone: trabecular number1.62.52.81.51.7
Bone: trabecular spacing1.62.12.3-1.4-1.5
Bone: trabecular thickness1.01.21.31.11.1
Bone: trabecular tissue density6.38.910.5-2.7-3.2
Water consumed over 24 hours0.30.30.4-0.6-0.5
Number of responses in last shaping day0.91.01.31.10.8