LOC102556302

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr7_130118788_130164148	0.05	0.04	2.7e-06	0.04	0.05	0.05	0.04	1.4e-05	2.7e-06	4.8e-06	6.5e-06
2	NAcc	gene expression	LOC102556302	0.06	0.06	4.6e-06	0.04	0.04	0.04	0.04	8.5e-06	7.2e-06	1.6e-05	1.2e-05
3	Adipose	alternative polyA	XR_001839040.2	0.07	0.06	3.3e-07	0.05	0.06	0.07	0.05	1.4e-06	5.0e-07	6.5e-08	1.3e-06
4	Adipose	alternative polyA	XR_593718.3	0.07	0.06	5.1e-07	0.05	0.06	0.06	0.05	2.0e-06	7.5e-07	1.4e-07	2.0e-06
5	Adipose	isoform ratio	XR_001839040.2	0.05	0.05	2.8e-05	0.04	0.04	0.06	0.03	5.0e-05	5.9e-05	4.9e-07	9.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	9.8	16.4	18.1	-4.3	4.2	4.0	-3.9	3.9
Area under the delay curve	1.0	1.0	1.1	-1.0	1.0	1.0	-1.0	1.0
BMI with tail	5.0	16.1	17.8	-3.7	3.9	4.2	-4.2	4.1
BMI without tail	0.1	0.2	0.4	0.2	-0.1	0.6	-0.7	0.5
Body weight	6.9	28.8	31.1	-5.0	5.2	5.5	-5.6	5.5
Weight adjusted by age	2.5	2.9	3.4	-1.5	1.6	1.8	-1.8	1.7
Bone surface	11.6	20.5	22.2	-4.7	4.7	4.4	-4.4	4.4
Bone volume	8.4	14.3	16.0	-4.0	4.0	3.7	-3.6	3.6
Breakpoint value in progressive ratio session	0.3	0.3	0.3	-0.5	0.5	0.6	-0.6	0.5
Number of licking bursts	0.2	0.2	0.6	0.8	-0.6	-0.1	-0.0	-0.1
Context. condit. distance diff. score	0.3	0.4	0.6	-0.5	0.6	0.7	-0.8	0.6
Locomotion velocity, session 1	1.4	1.5	1.8	1.0	-1.1	-1.3	1.3	-1.2
Locomotion distance, session 1	3.7	4.7	5.6	1.8	-1.9	-2.3	2.4	-2.3
Locomotion velocity, session 2	0.6	0.7	1.1	0.5	-0.5	-1.0	1.1	-0.9
Locomotion distance, session 2	3.1	4.3	5.2	1.8	-1.8	-2.3	2.3	-2.2
Locomotion velocity, session 3	4.3	5.0	5.3	2.2	-2.2	-2.3	2.3	-2.3
Locomotion distance, session 3	5.6	6.1	6.5	2.4	-2.4	-2.5	2.5	-2.6
Stereotopy head waving bouts, day 3	0.9	1.1	1.4	-1.2	1.2	0.9	-0.8	1.0
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.8	0.8	0.3	-0.3	0.6
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.5
Locomotion distance, session 7	1.4	1.8	2.3	1.5	-1.5	-1.2	1.2	-1.3
Stereotopy head waving bouts, day 7	0.9	1.0	1.3	-1.0	1.0	1.0	-0.9	1.1
Stereotopy head waving duration, day 7	1.2	1.4	1.7	-1.2	1.2	1.1	-1.1	1.3
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2	-0.1
Locomotion distance, session 8	1.3	1.9	2.2	1.3	-1.3	-1.4	1.4	-1.5
Degree of sensitization distance	0.7	0.7	0.9	-0.7	0.7	0.9	-1.0	0.9
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.4	0.4	0.5	-0.5	0.6
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.2	0.0	0.0	0.1
Cocaine response after cond. corrected	0.0	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2
Cocaine response after cond. not corrected	0.7	0.7	0.8	0.8	-0.8	-0.9	0.9	-0.9
Cocaine response before conditioning	3.4	4.1	4.4	2.1	-2.1	-2.0	2.0	-1.9
Saline control response	0.1	0.1	0.2	-0.4	0.4	0.4	-0.3	0.3
Bone: connectivity density	7.1	11.1	12.4	-3.5	3.5	3.2	-3.2	3.2
Bone: cortical apparent density	0.2	0.3	0.4	0.6	-0.7	-0.5	0.5	-0.6
Bone: cortical area	10.2	15.3	15.8	-3.8	3.9	4.0	-4.0	3.9
Bone: cortical porosity	1.1	1.3	1.6	0.8	-1.0	-1.2	1.3	-1.2
Bone: cortical porosity	1.7	1.8	2.2	1.1	-1.2	-1.4	1.5	-1.5
Bone: cortical thickness	3.8	6.3	6.8	-2.3	2.5	2.6	-2.6	2.6
Bone: cortical thickness	0.3	0.4	0.6	-0.3	0.4	0.7	-0.8	0.7
Bone: cortical tissue density	0.4	0.5	0.6	0.7	-0.8	-0.6	0.6	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.2	-0.2	-0.6	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.5	0.5	0.1	-0.1	0.2
Condit. Reinf. active responses	0.8	0.9	1.2	0.8	-0.8	-1.1	1.1	-1.0
Condit. Reinf. inactive responses	2.7	3.2	3.4	1.8	-1.8	-1.8	1.8	-1.7
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.2	0.0	-0.1	0.1
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.3	0.5	0.4	-0.5	0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.1	-0.2	-0.0	0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.6	-0.6	-0.5	0.5	-0.5
Condit. Reinf. active responses	0.1	0.2	0.3	0.5	-0.5	-0.3	0.3	-0.4
Condit. Reinf. inactive responses	0.5	0.6	0.8	0.9	-0.9	-0.7	0.7	-0.7
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.2	0.1
Condit. Reinf. lever reinforcers received	0.4	0.5	0.8	0.8	-0.9	-0.6	0.6	-0.7
Conditioned reinforcement - actives	1.4	1.4	1.8	1.3	-1.3	-1.1	1.0	-1.1
Conditioned reinforcement - inactives	1.9	2.1	2.6	1.6	-1.5	-1.4	1.4	-1.4
Conditioned locomotion	0.3	0.3	0.5	0.7	-0.7	-0.5	0.4	-0.5
Patch foraging indifference point 0 sec	2.0	3.2	3.7	1.9	-1.9	-1.8	1.7	-1.7
Patch foraging indifference point AUC	0.1	0.1	0.3	0.6	-0.5	-0.2	0.1	-0.2
Delay disc. indifference point, 0s delay	1.1	1.2	1.3	-1.1	1.2	1.0	-1.0	1.1
Delay disc. indifference point, 16s delay	1.1	1.1	1.3	-0.9	1.0	1.1	-1.1	1.1
Delay disc. indifference point, 2s delay	1.2	1.3	1.6	-1.3	1.3	1.0	-1.0	1.1
Delay disc. indifference point, 24s delay	1.7	1.6	1.8	-1.1	1.2	1.3	-1.3	1.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	0.5
Delay disc. indifference point, 8s delay	2.7	2.8	2.9	-1.6	1.7	1.7	-1.7	1.7
Indifference point function ln k	3.4	4.7	5.7	-2.4	2.4	2.0	-2.0	2.0
Indifference point function log k	3.4	4.7	5.7	-2.4	2.4	2.0	-2.0	2.0
Patch foraging total patch changes 0 sec	1.9	3.1	3.6	1.9	-1.9	-1.7	1.7	-1.6
Patch foraging total patch changes 12 sec	1.5	2.0	3.0	1.7	-1.6	-1.2	1.1	-1.2
Patch foraging total patch changes 18 sec	3.7	4.7	5.7	2.4	-2.4	-2.0	2.0	-2.0
Patch foraging total patch changes 24 sec	1.7	2.1	2.8	1.7	-1.6	-1.3	1.3	-1.3
Patch foraging total patch changes 6 sec	2.1	3.2	4.0	2.0	-2.0	-1.7	1.6	-1.6
Patch foraging time to switch 0 sec	2.2	3.5	3.6	1.9	-1.9	-1.8	1.8	-1.9
Patch foraging water rate 0 sec	2.9	4.6	4.8	-2.1	2.2	2.1	-2.1	2.2
Patch foraging water rate 12 sec	3.3	5.1	5.9	-2.4	2.4	2.2	-2.1	2.1
Patch foraging water rate 18 sec	0.3	0.4	0.5	-0.6	0.6	0.7	-0.7	0.6
Patch foraging water rate 24 sec	2.9	4.1	4.6	-2.1	2.1	2.0	-1.9	2.0
Patch foraging water rate 6 sec	3.3	4.9	5.5	-2.3	2.3	2.1	-2.1	2.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.4	-0.6	0.6	0.5	-0.5	0.6
Distance traveled before self-admin	1.1	1.2	1.2	1.1	-1.1	-1.1	1.1	-1.1
Distance traveled after self-admin	0.3	0.3	0.4	0.4	-0.4	-0.6	0.6	-0.5
Extensor digitorum longus weight	4.9	19.1	22.3	-3.9	4.1	4.6	-4.7	4.5
Bone: elastic displacement	5.2	5.9	6.9	2.2	-2.3	-2.6	2.6	-2.5
Bone: elastic work	0.1	0.1	0.2	-0.1	0.0	-0.4	0.5	-0.4
Bone: endosteal estimation	7.6	16.5	17.6	-4.2	4.1	4.0	-4.0	4.0
Bone: endosteal perimeter	7.5	15.5	16.7	-3.8	3.8	4.1	-4.1	3.9
Epididymis fat weight	0.1	0.3	0.4	-0.6	0.6	0.6	-0.5	0.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	0.5	0.4	-0.4	0.4
Delta time in open arm before/after self-admin	4.6	4.5	4.7	2.1	-2.0	-2.2	2.1	-2.1
Diff in mean of infusions in LGA sessions	1.3	1.5	1.8	-1.3	1.3	1.1	-1.1	1.2
Delay discount exponential model param	0.9	0.9	1.0	0.9	-1.0	-0.9	1.0	-1.0
Extinction: sum of active levers before priming	0.4	0.3	0.5	-0.7	0.7	0.5	-0.5	0.5
Active lever presses in extinction session 6	0.4	0.4	0.5	-0.7	0.7	0.6	-0.6	0.6
Bone: final force	9.7	15.7	17.2	-4.1	4.1	3.8	-3.8	3.9
Bone: final moment	9.9	16.0	18.3	-4.3	4.3	3.8	-3.8	3.8
Food consumed during 24 hour testing period	1.6	2.0	2.2	-1.5	1.5	1.4	-1.4	1.3
Glucose	0.2	0.3	0.6	-0.2	0.3	0.7	-0.8	0.6
Heart weight	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	0.1
Delay discount hyperbolic model param	0.8	0.9	0.9	0.9	-1.0	-0.9	0.9	-1.0
Intermittent access intake day 1-15 change	1.0	1.0	1.7	1.3	-1.2	-0.7	0.7	-0.9
Intermittent access intake escalation	0.7	0.7	1.2	1.1	-1.0	-0.5	0.5	-0.7
Intermittent access intake escalation 2	1.2	1.2	1.8	1.4	-1.3	-0.9	0.8	-1.0
Intermitt. access day 1 inactive lever presses	3.0	3.3	3.6	1.7	-1.7	-1.9	1.9	-1.9
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.5	1.2	-1.2	-1.2	1.2	-1.2
Intermitt. access escalation Index	0.2	0.2	0.2	0.4	-0.4	-0.3	0.3	-0.4
Intermittent access day 1 total infusions	1.1	1.3	1.4	1.2	-1.2	-1.1	1.1	-1.1
Intermittent access day 15 total infusions	2.0	2.3	3.4	1.8	-1.8	-1.2	1.1	-1.4
Intermittent access terminal intake (last 3 days)	2.5	2.7	3.5	1.9	-1.8	-1.4	1.4	-1.6
Intermittent access total infusions	2.2	2.5	3.3	1.8	-1.7	-1.4	1.3	-1.5
Intermittent access day 1 locomotion	0.8	0.8	1.0	1.0	-1.0	-0.8	0.8	-0.9
Intermittent access day 15 total locomotion	1.1	1.1	1.9	1.4	-1.3	-0.8	0.7	-1.0
Intermittent access total locomotion	2.6	2.9	4.0	2.0	-2.0	-1.5	1.4	-1.6
Intermittent access standard deviation	0.4	0.4	0.6	0.8	-0.7	-0.5	0.5	-0.6
Left kidney weight	0.3	0.7	1.1	-1.0	1.0	0.7	-0.7	0.8
Right kidney weight	2.8	7.8	8.2	-2.7	2.8	2.8	-2.8	2.9
Cocaine induced anxiety	1.3	1.6	2.0	-1.1	1.1	1.4	-1.4	1.2
Post-drug Anxiety	5.3	5.9	6.2	-2.4	2.4	2.5	-2.5	2.4
Baseline Anxiety	0.9	0.9	1.1	-1.0	1.1	0.9	-0.9	0.9
Tail length	0.1	0.2	0.4	0.6	-0.6	-0.2	0.2	-0.2
Length with tail	1.9	7.1	7.4	-2.7	2.7	2.7	-2.6	2.7
Length without tail	7.5	16.3	17.7	-4.1	4.2	4.0	-3.9	3.9
Times rat made contact with spout	0.0	0.0	0.1	0.3	-0.2	-0.2	0.1	-0.2
Lifetime Intake	1.9	2.2	3.3	1.8	-1.7	-1.2	1.1	-1.4
Liver weight, left	2.3	3.7	4.4	-1.7	1.8	2.1	-2.1	1.9
Liver weight, right	1.7	2.8	3.3	-1.6	1.6	1.8	-1.8	1.6
Locomotor activity	1.0	1.6	2.0	1.4	-1.4	-1.2	1.1	-1.2
Locomotor testing distance	2.8	4.6	5.3	2.3	-2.3	-2.1	2.0	-2.1
Locomotor testing rearing	1.9	2.9	3.9	2.0	-1.9	-1.5	1.5	-1.5
Locomotion in novel chamber	0.6	0.7	0.8	-0.8	0.8	0.8	-0.8	0.9
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1
Fecal boli incidents, locomotor time 1	2.1	2.3	2.4	1.6	-1.5	-1.6	1.5	-1.5
Change in fecal boli incidents, locomotor task	1.0	1.0	1.5	-1.2	1.2	0.8	-0.7	0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	0.1	-0.3	0.3	-0.2
Total resting periods, locomotor time 1	0.4	0.4	0.7	0.4	-0.4	-0.8	0.8	-0.7
Rest time, locomotor task time 1	0.4	0.5	0.6	0.6	-0.6	-0.8	0.8	-0.7
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.2	0.1	0.4	-0.3	0.3
Vertical activity count, locomotor time 1	1.5	1.6	1.8	-1.2	1.2	1.3	-1.3	1.2
Time >=10cm from walls, locomotor time 2	0.8	0.8	0.9	0.9	-0.8	-1.0	0.9	-0.9
Bouts of movement, locomotor time 2	2.5	2.7	2.9	-1.7	1.7	1.6	-1.6	1.7
Total resting periods, locomotor time 2	2.9	3.1	3.3	-1.8	1.8	1.7	-1.7	1.8
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.1	0.2	0.3	-0.3	0.3
Distance moved, locomotor task time 2	0.1	0.2	0.2	0.2	-0.3	-0.5	0.5	-0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.1	0.1	0.3	-0.4	0.3
Light reinforcement 1	2.4	4.4	5.6	2.3	-2.4	-1.9	1.9	-2.0
Light reinforcement 2	0.8	1.0	1.3	1.2	-1.1	-0.9	0.9	-0.9
Bone: marrow area	7.5	16.2	17.2	-4.2	4.1	4.0	-3.9	3.9
Bone: maximum diameter	4.4	8.2	9.3	-2.5	2.7	3.0	-3.0	3.0
Bone: maximum force	13.7	23.7	26.4	-5.1	5.1	4.7	-4.7	4.7
Bone: maximum moment	13.8	23.8	27.7	-5.3	5.1	4.7	-4.6	4.6
Mean time between licks in bursts	0.3	0.4	0.7	0.2	-0.3	-0.8	0.8	-0.7
Mean num. licks in bursts	0.1	0.2	0.3	-0.2	0.1	-0.5	0.5	-0.5
Cd content in liver	0.5	0.5	0.8	0.9	-0.8	-0.6	0.5	-0.7
Co content in liver	0.3	0.3	0.9	0.9	-0.7	-0.3	0.1	-0.2
Cu content in liver	0.6	0.8	1.0	-0.9	1.0	0.9	-0.9	0.7
Fe content in liver	0.1	0.2	0.5	0.7	-0.6	-0.1	-0.0	-0.2
K content in liver	0.3	0.3	0.4	-0.4	0.5	0.6	-0.6	0.6
Mg content in liver	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.1
Mn content in liver	0.0	0.0	0.1	-0.3	0.2	-0.1	0.2	0.0
Na content in liver	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.0	-0.1
Rb content in liver	0.2	0.3	0.5	0.7	-0.6	-0.4	0.3	-0.4
Se content in liver	0.6	0.7	0.9	0.9	-0.9	-0.8	0.8	-0.7
Sr content in liver	0.5	0.5	0.8	-0.5	0.6	0.8	-0.9	0.7
Zn content in liver	1.4	1.6	2.4	1.5	-1.4	-1.1	1.1	-1.1
Bone: minimum diameter	9.3	17.5	17.9	-4.2	4.2	4.2	-4.2	4.1
Time in familiar zone, hab. session 1	0.6	0.6	0.8	0.5	-0.5	-0.9	0.9	-0.8
Time in novel zone, hab. session 1	0.5	0.5	0.7	-0.5	0.5	0.8	-0.8	0.8
Total zone transitions, hab. session 1	0.4	0.6	0.7	0.7	-0.7	-0.8	0.8	-0.8
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.1	0.1	-0.3	0.3	-0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.2	0.1	-0.1	0.2	-0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.6	0.6	0.2	-0.2	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	-0.5	-0.2	0.2	-0.3
Total zone transitions, hab. session 2	0.5	0.6	0.9	0.6	-0.6	-0.9	0.9	-0.9
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.3	-0.3	-0.8	0.8	-0.7
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.1	-0.2	-0.6	0.6	-0.5
Novel to familiar place preference ratio	2.4	2.4	2.9	-1.4	1.4	1.7	-1.7	1.6
Novelty place preference	1.8	1.8	2.3	-1.2	1.2	1.5	-1.5	1.4
Time in novel zone, NPP test	1.5	1.6	2.0	-1.1	1.0	1.4	-1.4	1.3
Total zone transitions, NPP test	1.6	2.3	2.8	1.4	-1.3	-1.7	1.6	-1.6
Total locomotion distance, NPP test	2.2	3.1	3.7	1.5	-1.5	-1.9	1.9	-1.9
Locomotion velocity, NPP test	1.3	1.8	2.3	1.1	-1.1	-1.5	1.5	-1.5
Intraocular pressure	7.6	10.6	11.1	3.3	-3.3	-3.2	3.2	-3.2
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	0.2
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	0.1
Parametrial fat weight	2.1	4.1	4.3	2.1	-2.0	-2.0	2.0	-2.0
Pavlov. Cond. lever latency	0.0	0.1	0.2	-0.4	0.3	-0.0	0.2	-0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.0	0.2	0.4	-0.5	0.3
Pavlov. Cond. index score	0.1	0.2	0.4	0.0	0.1	0.5	-0.6	0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	0.1	0.4	-0.5	0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.9	-0.7	-0.3	0.2	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.1	-0.1	0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	0.6	-0.6	-1.2	1.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.3	0.5	0.8	-0.9	0.7
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	-0.3	-0.0	-0.0	-0.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry latency	1.1	1.3	1.3	-1.2	1.1	1.1	-1.1	1.1
Pavlov. Cond. change in total contacts	1.9	2.7	3.4	-1.3	1.4	1.8	-1.9	1.7
Pavlov. Cond. index score	0.6	0.8	1.0	-0.8	0.8	1.0	-1.0	0.9
Pavlov. Cond. latency score	0.7	0.8	1.0	-0.8	0.9	1.0	-1.0	0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	-0.4	-0.1	0.1	-0.2
Pavlov. Cond. magazine entry number	2.5	3.1	3.4	1.7	-1.7	-1.8	1.8	-1.7
Pavlov. Cond. intertrial magazine entries	5.5	7.1	7.4	2.7	-2.6	-2.7	2.7	-2.6
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.7	-1.1	1.1	1.3	-1.3	1.2
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.0	0.2	-0.2	0.1
Time in closed arm before self-admin	1.8	2.1	2.5	-1.3	1.3	1.6	-1.6	1.5
Time in closed arm after self-admin	0.8	0.8	0.8	-0.9	0.8	0.9	-0.9	0.9
Time in open arm before self-admin	0.7	0.8	0.9	-0.9	0.8	1.0	-0.9	0.9
Time in open arm after self-admin	0.3	0.4	0.5	0.5	-0.5	-0.7	0.7	-0.6
Bone: periosteal estimation	12.3	25.4	26.0	-5.0	5.0	5.1	-5.1	5.0
Bone: periosteal perimeter	10.7	17.8	18.4	-4.1	4.2	4.3	-4.3	4.2
Bone: post-yield work	8.3	11.3	12.4	-3.5	3.4	3.3	-3.2	3.3
Progressive ratio test 1 active lever presses	4.0	4.1	5.2	2.3	-2.2	-1.9	1.8	-2.0
Progressive ratio test 1 breakpoint	3.5	3.7	4.8	2.2	-2.1	-1.7	1.7	-1.8
Progressive ratio test 1 inactive lever presses	3.3	3.6	4.2	2.1	-2.0	-1.8	1.8	-1.8
Progressive ratio test 2 active lever presses	1.9	2.0	2.9	1.7	-1.7	-1.2	1.1	-1.3
Progressive ratio test 2 breakpoint	2.4	2.7	3.8	2.0	-1.9	-1.4	1.4	-1.5
Progressive ratio test 2 inactive lever presses	2.2	2.5	3.2	1.8	-1.8	-1.4	1.4	-1.5
Incentive Sensitization - Responses	0.1	0.1	0.1	0.0	0.0	0.3	-0.4	0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3
Progressive ratio	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.1
Food seeking constrained by brief footshock	0.3	0.3	0.5	0.7	-0.6	-0.5	0.5	-0.6
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.2
Retroperitoneal fat weight	0.4	1.3	1.7	1.3	-1.2	-1.0	0.9	-1.1
Reaction time number correct	0.9	1.4	2.5	-1.6	1.4	0.9	-0.8	0.9
Reaction time mean minus median	7.8	10.3	11.3	3.4	-3.3	-3.1	3.1	-3.1
Reaction time mean minus median AUC	5.7	7.4	8.0	2.8	-2.8	-2.7	2.7	-2.7
Reaction time num false alarms	1.7	2.4	2.5	1.5	-1.5	-1.6	1.6	-1.5
Reaction time num false alarms AUC	2.5	3.4	3.5	1.8	-1.9	-1.9	1.9	-1.8
Reaction time trials correct on left	0.9	1.4	2.5	-1.6	1.4	0.9	-0.8	0.9
Reaction time trials on left	0.7	1.0	1.9	-1.4	1.2	0.7	-0.6	0.8
Reaction time mean	0.5	0.7	1.0	1.0	-0.9	-0.7	0.7	-0.7
Reaction time mean AUC	0.3	0.3	0.5	0.7	-0.7	-0.5	0.5	-0.5
Median of all reaction times	0.0	0.1	0.1	-0.1	0.1	0.3	-0.4	0.3
Reaction time omissions	10.3	14.0	14.2	3.7	-3.8	-3.7	3.7	-3.8
Reaction time false alarm rate	2.4	3.3	4.0	2.0	-2.0	-1.7	1.7	-1.7
Reaction time premature initiation rate	5.1	6.8	9.6	3.1	-3.0	-2.3	2.2	-2.4
Reaction time premature initiations	2.5	3.6	4.5	2.1	-2.1	-1.7	1.7	-1.8
Std. dev. reaction times	5.8	8.1	8.8	3.0	-3.0	-2.8	2.7	-2.8
Reaction time trials completed	0.7	1.0	1.9	-1.4	1.2	0.7	-0.6	0.8
Reaction time trials AUC	1.2	1.7	3.1	-1.8	1.6	1.0	-0.9	1.1
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1
Run reversals in cocaine runway, males	1.6	1.5	1.6	1.2	-1.2	-1.3	1.2	-1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1
Latency to leave start box in cocaine runway, F	1.6	1.8	2.1	1.4	-1.4	-1.3	1.2	-1.3
Latency to leave start box in cocaine runway, M	2.2	2.1	2.3	-1.4	1.4	1.5	-1.5	1.5
Std. dev. time between licks in bursts	0.8	1.0	1.4	1.2	-1.2	-0.9	0.8	-0.9
Total sessions with >9 infusions	0.6	0.6	1.3	1.1	-1.0	-0.5	0.4	-0.6
Short access day 1 total inactive lever presses	1.0	1.1	1.8	1.4	-1.3	-0.8	0.8	-1.0
Short access day 10 total inactive lever presses	0.2	0.3	0.3	0.4	-0.5	-0.5	0.6	-0.5
Short access day 1 total infusions	0.0	0.0	0.1	0.3	-0.2	0.1	-0.1	-0.0
Short access day 10 total infusions	0.6	0.7	1.3	1.1	-1.0	-0.6	0.6	-0.7
Short access total infusions	0.3	0.3	0.8	0.9	-0.7	-0.2	0.1	-0.3
Short access day 1 locomotion	0.1	0.1	0.2	0.4	-0.3	0.0	-0.1	-0.0
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.4
Short access total locomotion	0.3	0.3	0.5	0.7	-0.7	-0.3	0.3	-0.4
One hour access (0.3 mA shock)	0.1	0.2	0.4	0.7	-0.6	-0.1	0.0	-0.3
Compulsive drug intake	0.7	0.7	1.1	-1.1	1.0	0.6	-0.5	0.8
One hour access (shock baseline)	0.1	0.1	0.3	0.6	-0.5	0.1	-0.3	-0.1
Social response proportion	0.1	0.1	0.2	0.4	-0.3	-0.2	0.2	-0.2
Social responses	6.5	8.4	10.7	3.3	-3.2	-2.6	2.6	-2.7
Social time	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.2
Soleus weight	0.7	2.0	2.2	-1.3	1.3	1.5	-1.5	1.4
Bone: stiffness	16.9	26.7	27.9	-5.3	5.2	5.2	-5.1	5.1
Tibialis anterior weight	1.7	5.8	8.7	-1.6	1.8	2.8	-3.0	2.6
Time to tail flick, vehicle, before self-admin	1.2	1.3	1.6	0.9	-1.0	-1.2	1.3	-1.1
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.3	-0.5	0.5	0.5	-0.5	0.5
Time to tail flick, test, before self-admin	0.6	0.6	0.8	0.5	-0.6	-0.9	0.9	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.2	-0.5	0.4	0.5	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.7	-0.6	0.7	0.8	-0.8	0.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.4	0.4	0.6	-0.6	0.6
Tibia length	8.1	22.9	24.2	-4.5	4.6	4.9	-4.9	4.9
Ambulatory time before self-admin	4.0	4.2	4.2	2.0	-2.0	-2.1	2.0	-2.0
Ambulatory time after self-admin	1.8	1.9	2.1	1.4	-1.4	-1.4	1.4	-1.3
Bone: tissue strength	0.8	0.8	1.4	-1.2	1.0	0.7	-0.6	0.7
Total heroin consumption	2.2	2.6	2.9	-1.5	1.5	1.7	-1.7	1.6
Bone: trabecular number	5.7	8.9	10.9	-3.3	3.2	2.8	-2.7	2.8
Bone: trabecular spacing	2.1	2.7	3.4	1.8	-1.8	-1.6	1.5	-1.5
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.4	-0.3	0.3	-0.4
Bone: trabecular tissue density	0.1	0.1	0.1	0.3	-0.3	-0.3	0.4	-0.3
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1	-0.1
Number of responses in last shaping day	0.3	0.3	0.6	-0.1	0.1	0.7	-0.8	0.5