LOC102555928

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	intron excision ratio	chr1_144866427_144875844	0.1	0.07	2.5e-03	0.04	0.05	0.05	0.05	7.6e-03	3.3e-03	5.4e-03	5.2e-03
2	pVTA	intron excision ratio	chr1_144866427_144875844	0.06	0.04	4.7e-05	0.03	0.04	0.04	0.04	1.9e-03	2.4e-04	1.5e-04	4.0e-04
3	Brain	intron excision ratio	chr1_144866427_144875844	0.06	0.04	4.6e-04	0.01	0.01	0.01	0.01	1.4e-02	1.6e-02	2.2e-02	1.5e-02
4	Eye	intron excision ratio	chr1_144866427_144874803	0.51	0.21	8.0e-03	0.04	0.05	0.12	0.1	7.4e-02	5.8e-02	7.2e-03	1.3e-02
5	PL	mRNA stability	LOC102555928	0.1	0.13	2.3e-03	0.04	0.02	0.02	0.02	3.7e-05	3.6e-03	3.4e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.6	2.7	4.7	2.2	1.9	1.8	-1.3	-0.5
Area under the delay curve	0.5	0.6	1.9	-0.7	-0.2	-0.7	1.4	-0.1
BMI with tail	3.5	12.1	23.9	-4.9	-4.2	-3.1	0.2	3.1
BMI without tail	1.6	4.8	9.1	-3.0	-2.3	-2.4	1.7	0.8
Body weight	0.9	3.9	5.5	-2.4	-2.3	-2.1	0.8	1.9
Weight adjusted by age	0.9	1.4	3.0	1.4	1.7	1.1	-0.1	-1.1
Bone surface	2.0	3.7	6.4	2.4	2.5	1.6	-0.0	-1.9
Bone volume	1.5	2.7	4.9	2.1	2.2	1.4	-0.1	-1.4
Breakpoint value in progressive ratio session	0.6	0.7	1.6	-0.5	-0.6	-1.1	1.3	-0.4
Number of licking bursts	0.9	1.4	3.6	1.9	1.2	0.9	-0.5	-1.0
Context. condit. distance diff. score	0.5	0.6	1.1	1.1	1.0	0.4	-0.4	-0.6
Locomotion velocity, session 1	0.5	0.5	1.0	-0.6	-1.0	-1.0	0.3	0.0
Locomotion distance, session 1	0.1	0.2	0.5	-0.0	-0.2	-0.7	0.4	-0.4
Locomotion velocity, session 2	0.2	0.2	0.7	-0.1	-0.5	-0.8	0.4	0.3
Locomotion distance, session 2	0.1	0.1	0.2	0.3	0.2	-0.2	0.1	-0.5
Locomotion velocity, session 3	1.4	1.6	3.9	0.1	0.7	-0.7	1.7	-2.0
Locomotion distance, session 3	2.2	2.4	5.3	0.4	0.9	-1.0	2.2	-2.3
Stereotopy head waving bouts, day 3	3.9	4.5	6.5	2.5	2.1	2.6	-2.3	-0.1
Stereotopy head waving duration, day 3	0.3	0.3	1.0	0.2	0.5	0.6	0.0	-1.0
Locomotion velocity, session 7	2.3	2.6	4.7	-2.1	-1.2	-2.2	1.6	-0.3
Locomotion distance, session 7	0.6	0.8	1.5	-1.1	-0.3	-1.2	0.9	-0.7
Stereotopy head waving bouts, day 7	1.3	1.4	2.4	1.0	1.5	1.5	-0.4	-1.2
Stereotopy head waving duration, day 7	0.5	0.6	1.7	0.2	0.8	0.5	0.5	-1.3
Locomotion velocity, session 8	1.5	1.7	3.5	-1.6	-1.4	-1.9	0.8	-0.2
Locomotion distance, session 8	0.4	0.6	1.8	1.3	0.9	0.1	-0.3	-0.7
Degree of sensitization distance	0.6	0.6	1.3	-1.2	-0.8	0.1	-0.5	0.9
Degree of sensitization stereotypy	0.2	0.3	0.6	0.2	0.6	0.7	-0.2	-0.5
Conditioned locomotion	0.4	0.4	1.0	-0.1	0.2	0.7	-1.0	0.8
Cocaine response after cond. corrected	0.4	0.5	1.6	-0.6	-0.8	-0.0	-0.3	1.3
Cocaine response after cond. not corrected	0.4	0.5	1.1	-0.8	-0.8	-0.5	-0.1	1.0
Cocaine response before conditioning	0.5	0.6	1.1	1.0	1.0	0.0	0.1	-0.9
Saline control response	2.3	3.1	8.0	-0.9	-0.2	-2.2	2.8	-1.3
Bone: connectivity density	2.3	3.5	5.8	2.4	1.9	2.1	-2.0	-0.3
Bone: cortical apparent density	1.5	2.0	3.3	-1.5	-1.8	-1.1	-0.5	1.8
Bone: cortical area	1.9	2.9	5.8	2.3	2.4	1.0	0.8	-1.2
Bone: cortical porosity	0.5	0.5	1.2	0.3	0.8	1.1	-0.5	-0.5
Bone: cortical porosity	0.3	0.3	0.7	0.3	0.8	0.8	-0.3	-0.5
Bone: cortical thickness	0.1	0.2	0.5	0.6	0.7	0.3	0.5	0.1
Bone: cortical thickness	1.3	1.6	3.9	-0.1	-0.5	0.8	-2.0	1.7
Bone: cortical tissue density	1.5	2.1	3.6	-1.4	-1.8	-1.0	-0.6	1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.2	-0.1	-0.2	-0.1	0.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.4	1.2	1.6	0.8	0.3	-1.3
Condit. Reinf. active responses	0.3	0.4	1.4	-0.5	-0.4	-0.1	-0.4	1.2
Condit. Reinf. inactive responses	0.6	0.7	1.6	-1.0	-0.9	-0.4	-0.2	1.3
Incentive salience index mean	0.9	1.1	1.7	-0.9	-1.1	-1.3	0.6	1.1
Condit. Reinf. lever presses	3.9	5.5	8.5	-2.4	-2.7	-2.9	1.7	1.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	-0.6	-0.3	-0.2	0.6
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.6	-0.5	-0.5	0.5	-1.2	1.0
Condit. Reinf. active responses	0.4	0.6	1.3	-0.5	-0.4	-1.1	1.1	-0.1
Condit. Reinf. inactive responses	2.4	3.1	8.4	-0.4	-0.2	-2.3	2.9	-1.2
Condit. Reinf. lever presses	2.8	3.9	7.0	-1.6	-0.7	-2.5	2.6	-1.7
Condit. Reinf. lever reinforcers received	0.7	1.0	2.3	-0.7	-0.5	-1.5	1.3	-0.1
Conditioned reinforcement - actives	0.8	1.4	2.6	1.3	1.5	1.6	-0.7	-0.5
Conditioned reinforcement - inactives	1.6	2.3	3.8	1.9	2.0	1.6	-0.9	-1.0
Conditioned locomotion	0.5	0.6	1.8	0.3	0.4	1.0	-1.3	0.4
Patch foraging indifference point 0 sec	0.5	0.9	2.5	0.3	0.7	-0.6	1.6	-1.1
Patch foraging indifference point AUC	1.9	2.8	4.6	2.0	2.1	1.7	-1.1	-1.1
Delay disc. indifference point, 0s delay	0.2	0.3	0.4	0.4	0.5	0.6	-0.4	0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.4	0.3	-0.0	0.6	-0.2
Delay disc. indifference point, 2s delay	0.7	0.8	2.8	-0.4	-0.1	-0.6	1.7	-0.8
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.4	0.2	-0.0	0.2	-0.1
Delay disc. indifference point, 4s delay	2.1	2.2	6.2	-1.1	-0.8	-1.8	2.5	-0.2
Delay disc. indifference point, 8s delay	0.3	0.4	1.1	-1.0	-0.6	-0.4	0.5	0.3
Indifference point function ln k	1.8	3.2	6.2	-2.5	-1.9	-1.5	1.9	0.4
Indifference point function log k	1.8	3.2	6.2	-2.5	-1.9	-1.5	1.9	0.4
Patch foraging total patch changes 0 sec	0.6	1.2	2.7	0.4	0.9	-0.4	1.7	-1.4
Patch foraging total patch changes 12 sec	5.5	7.2	12.9	3.3	3.6	2.7	-1.6	-1.5
Patch foraging total patch changes 18 sec	2.0	3.0	6.1	2.2	2.5	1.4	-0.1	-1.4
Patch foraging total patch changes 24 sec	1.1	1.8	3.7	1.9	1.8	0.3	0.5	-1.4
Patch foraging total patch changes 6 sec	0.9	1.3	2.5	1.3	1.6	0.2	0.8	-1.3
Patch foraging time to switch 0 sec	0.6	1.2	2.2	1.3	1.5	0.9	-0.2	-1.1
Patch foraging water rate 0 sec	0.6	1.3	2.3	-1.5	-1.5	-0.8	-0.0	1.1
Patch foraging water rate 12 sec	5.1	10.6	18.3	-4.3	-4.1	-3.4	1.3	2.1
Patch foraging water rate 18 sec	2.9	4.6	7.7	-2.7	-2.8	-2.3	1.4	0.9
Patch foraging water rate 24 sec	2.0	2.8	4.8	-2.0	-2.2	-1.6	0.3	1.5
Patch foraging water rate 6 sec	4.9	7.1	11.1	-3.3	-3.3	-2.5	-0.2	2.6
Seeking ratio, delayed vs. immediate footshock	3.1	3.8	9.2	0.0	-0.1	1.3	-3.0	2.8
Distance traveled before self-admin	0.7	0.9	1.9	-0.4	-1.0	-1.4	1.2	0.0
Distance traveled after self-admin	1.3	1.6	4.3	2.1	1.1	0.5	0.4	-1.4
Extensor digitorum longus weight	0.3	1.3	2.1	-1.5	-1.4	-1.2	1.0	0.3
Bone: elastic displacement	3.4	4.0	10.6	-1.1	-1.9	-0.0	-2.1	3.3
Bone: elastic work	1.0	1.3	3.1	-1.2	-1.2	-0.6	-0.6	1.8
Bone: endosteal estimation	4.2	9.2	15.6	3.6	3.9	2.9	-0.7	-2.9
Bone: endosteal perimeter	2.8	6.0	10.3	3.2	3.2	2.4	-0.4	-1.9
Epididymis fat weight	1.4	4.6	8.6	-2.4	-2.6	-1.2	-0.5	2.9
Delta time in closed arm before/after self-admin	1.2	1.1	2.5	0.1	1.0	1.6	-1.5	-0.1
Delta time in open arm before/after self-admin	4.1	4.1	6.9	-1.7	-2.2	-2.6	2.2	0.6
Diff in mean of infusions in LGA sessions	0.4	0.5	1.6	0.3	0.1	-0.6	1.3	-0.7
Delay discount exponential model param	0.7	0.7	2.4	0.7	0.3	0.8	-1.6	0.2
Extinction: sum of active levers before priming	2.1	2.3	4.4	-1.5	-2.1	-0.9	-0.9	1.8
Active lever presses in extinction session 6	1.9	1.9	3.1	-1.3	-1.8	-1.0	-0.8	1.7
Bone: final force	2.0	3.1	6.2	2.5	2.4	1.4	-0.2	-1.4
Bone: final moment	1.7	2.8	5.4	2.3	2.2	1.4	-0.3	-1.2
Food consumed during 24 hour testing period	2.0	2.7	4.6	2.1	2.1	1.2	0.6	-1.8
Glucose	0.1	0.2	0.4	-0.5	-0.3	0.5	-0.2	0.7
Heart weight	2.3	3.6	5.6	-2.4	-2.3	-1.6	-0.0	2.2
Delay discount hyperbolic model param	0.7	0.8	2.6	0.7	0.3	0.9	-1.6	0.3
Intermittent access intake day 1-15 change	0.4	0.7	1.2	1.1	1.1	0.9	-0.1	-0.7
Intermittent access intake escalation	0.5	1.1	1.8	1.3	1.3	1.0	-0.0	-0.9
Intermittent access intake escalation 2	1.3	1.4	2.7	1.6	1.5	1.1	-0.3	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	-0.2	-0.6	-0.4	-0.6	0.7
Intermitt. access day 15 inactive lever presses	0.3	0.7	1.0	1.0	0.9	0.9	-0.7	-0.4
Intermitt. access escalation Index	0.4	0.5	2.0	-0.2	-0.3	-0.7	1.4	-0.3
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.1	0.2	0.4	-0.5	0.3
Intermittent access day 15 total infusions	0.2	0.3	0.5	0.6	0.6	0.7	-0.2	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.3	0.5	0.6	-0.3	0.2
Intermittent access total infusions	0.3	0.4	0.9	-0.1	0.0	0.6	-1.0	0.7
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.2	0.1	0.2	-0.5	0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.5	-0.6	-0.3	0.0	-0.2	0.7
Intermittent access total locomotion	0.5	0.6	1.3	0.7	0.9	1.1	-0.9	0.0
Intermittent access standard deviation	0.2	0.5	1.0	0.9	1.0	0.4	0.3	-0.7
Left kidney weight	0.5	2.1	6.1	1.1	0.3	1.1	-2.5	1.4
Right kidney weight	0.0	0.1	0.4	0.1	-0.1	0.0	-0.2	0.6
Cocaine induced anxiety	0.3	0.4	0.7	0.8	0.8	0.6	-0.5	-0.5
Post-drug Anxiety	0.3	0.3	0.8	0.6	0.4	0.3	-0.9	-0.1
Baseline Anxiety	3.4	3.9	6.4	-2.3	-2.5	-2.1	0.5	1.8
Tail length	0.4	1.5	2.5	1.5	1.2	0.1	1.6	-1.2
Length with tail	0.2	1.0	2.4	1.5	0.8	-0.3	1.3	-0.4
Length without tail	0.1	0.3	1.2	0.5	-0.3	-0.3	-0.3	1.1
Times rat made contact with spout	0.3	0.4	0.9	-0.1	-0.9	-0.3	-0.7	0.7
Lifetime Intake	0.2	0.3	0.7	-0.4	-0.2	0.3	-0.7	0.8
Liver weight, left	0.3	0.5	1.2	-0.7	-0.4	0.4	-1.1	0.8
Liver weight, right	0.2	0.4	0.7	0.1	0.0	0.8	-0.8	0.6
Locomotor activity	0.5	0.8	1.9	-0.8	0.1	-0.3	1.1	-1.4
Locomotor testing distance	0.8	1.5	2.7	-1.6	-1.0	-1.3	1.3	-0.7
Locomotor testing rearing	0.7	1.4	2.2	-1.3	-0.6	-1.4	1.5	-0.9
Locomotion in novel chamber	0.2	0.2	0.4	-0.2	0.2	-0.7	0.7	-0.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.6	-0.8	-0.4	-0.6	0.5	-0.3
Fecal boli incidents, locomotor time 1	0.8	1.1	2.3	1.2	0.1	1.0	-1.5	0.9
Change in fecal boli incidents, locomotor task	0.7	0.7	1.7	-1.3	-0.4	-0.7	1.1	-0.1
Time >=10cm from walls, locomotor time 1	2.4	2.5	3.7	-1.8	-1.8	-1.9	1.3	0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.1	-0.1	0.4	-0.5	0.7
Total resting periods, locomotor time 1	0.3	0.4	0.7	0.4	0.0	0.5	-0.8	0.8
Rest time, locomotor task time 1	2.2	2.7	5.1	2.3	1.7	1.9	-1.2	-0.7
Distance moved, locomotor task time 1	1.2	1.8	3.7	-1.9	-1.5	-1.5	0.8	0.8
Vertical activity count, locomotor time 1	0.3	0.7	1.1	-0.8	-0.7	-1.0	1.0	-0.1
Time >=10cm from walls, locomotor time 2	0.2	0.3	1.0	0.3	0.2	-0.2	1.0	-0.5
Bouts of movement, locomotor time 2	2.6	4.2	6.4	2.2	2.5	2.4	-0.6	-1.8
Total resting periods, locomotor time 2	3.1	5.5	8.0	2.6	2.8	2.8	-1.1	-1.8
Rest time, locomotor task time 2	3.0	3.8	5.8	2.4	1.6	2.3	-2.3	0.0
Distance moved, locomotor task time 2	0.4	0.5	1.7	-0.3	0.1	-0.5	1.3	-0.6
Vertical activity count, locomotor time 2	0.2	0.3	0.7	0.1	0.2	-0.3	0.8	-0.7
Light reinforcement 1	3.3	8.0	17.5	4.2	3.3	2.7	-1.2	-1.6
Light reinforcement 2	3.7	5.6	12.5	3.5	2.1	2.6	-2.0	-0.6
Bone: marrow area	4.3	9.5	15.8	3.7	4.0	3.0	-0.8	-2.9
Bone: maximum diameter	3.2	6.0	10.8	3.0	3.3	1.6	1.1	-2.6
Bone: maximum force	1.4	2.6	5.4	1.9	2.3	1.2	0.1	-1.5
Bone: maximum moment	1.1	2.0	4.4	1.6	2.1	1.2	0.1	-1.2
Mean time between licks in bursts	1.4	3.4	5.9	1.7	1.5	2.4	-2.4	0.7
Mean num. licks in bursts	1.7	2.7	4.8	-2.2	-2.1	-0.9	-0.3	1.8
Cd content in liver	0.5	0.6	1.2	-0.4	0.0	1.0	-1.1	0.9
Co content in liver	0.2	0.2	0.5	0.1	0.3	0.7	-0.7	0.2
Cu content in liver	0.6	0.7	2.5	0.0	-0.3	-0.9	1.6	-0.4
Fe content in liver	0.4	0.5	0.9	0.8	0.6	-0.2	0.9	-0.8
K content in liver	1.8	1.7	3.7	1.0	0.8	-0.8	1.9	-1.7
Mg content in liver	1.8	1.8	3.8	1.0	1.0	-0.5	1.7	-1.9
Mn content in liver	0.1	0.1	0.3	-0.0	0.0	-0.2	0.2	0.5
Na content in liver	3.9	4.2	8.7	1.5	1.1	-1.2	2.9	-2.8
Rb content in liver	0.4	0.5	1.7	0.0	0.5	0.3	0.5	-1.3
Se content in liver	0.2	0.2	0.8	0.9	0.4	0.1	0.1	-0.1
Sr content in liver	0.8	0.7	1.6	0.0	0.4	-0.1	1.3	-1.2
Zn content in liver	1.1	1.2	2.0	1.2	1.2	0.1	1.0	-1.4
Bone: minimum diameter	4.4	8.1	14.0	3.7	3.7	3.0	-1.1	-1.7
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.0	-0.2	-0.5	0.4	-0.4
Time in novel zone, hab. session 1	0.3	0.3	0.8	-0.4	-0.3	0.3	-0.6	0.9
Total zone transitions, hab. session 1	2.3	3.2	7.2	-1.1	-0.7	-2.3	2.7	-1.3
Total locomotion distance, hab. session 1	1.8	2.6	3.6	1.9	1.3	1.5	-1.7	1.6
Locomotion velocity, hab. session 1	1.6	2.3	3.1	1.8	1.2	1.3	-1.6	1.7
Time in familiar zone, hab. session 2	0.4	0.4	0.6	0.8	0.7	0.8	-0.3	-0.3
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	-0.6	-0.5	0.2	0.3
Total zone transitions, hab. session 2	2.5	3.2	8.5	-0.7	-0.4	-2.0	2.9	-1.6
Total locomotion distance, hab. session 2	2.4	3.1	6.4	2.5	1.9	1.8	-1.3	0.5
Locomotion velocity, hab. session 2	2.0	2.6	5.9	2.4	1.7	1.5	-1.2	0.7
Novel to familiar place preference ratio	0.6	0.6	1.4	0.2	0.8	0.3	1.0	-1.2
Novelty place preference	0.5	0.5	1.2	0.1	0.7	0.4	0.9	-1.1
Time in novel zone, NPP test	0.4	0.4	0.9	-0.4	0.3	0.1	1.0	-0.9
Total zone transitions, NPP test	0.8	1.2	2.7	-0.9	-1.1	-1.6	1.2	0.0
Total locomotion distance, NPP test	3.9	5.3	9.1	2.3	1.4	2.4	-3.0	2.1
Locomotion velocity, NPP test	4.4	6.2	9.6	2.8	1.7	2.6	-3.1	1.9
Intraocular pressure	0.4	0.6	1.7	-1.3	-0.3	-0.4	0.9	-0.4
Delta distance traveled before/after self-admin	4.1	4.3	6.3	2.5	2.5	2.2	-0.7	-1.9
Delta ambulatory time before/after self-admin	2.2	2.7	4.2	2.1	1.8	2.0	-1.2	-1.0
Parametrial fat weight	2.4	5.6	7.9	-2.8	-2.7	-2.6	0.9	2.4
Pavlov. Cond. lever latency	1.2	1.5	3.5	1.0	1.3	1.9	-0.8	-0.8
Pavlov. Cond. magazine entry latency	1.7	2.2	3.9	-1.2	-1.5	-2.0	0.9	1.6
Pavlov. Cond. change in total contacts	0.6	0.6	2.2	0.5	-0.2	-0.4	-0.7	1.5
Pavlov. Cond. index score	1.6	2.1	4.1	-1.1	-1.6	-2.0	0.9	1.3
Pavlov. Cond. latency score	1.8	2.3	5.0	-1.2	-1.6	-2.2	1.2	1.1
Pavlov. Cond. lever contacts	1.0	1.2	3.3	-0.7	-1.0	-1.8	0.9	0.7
Pavlov. Cond. magazine entry number	1.9	2.4	4.3	1.4	1.7	2.1	-1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	0.5	0.3	-0.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.6	1.9	3.8	-0.9	-1.6	-1.9	0.6	1.5
Pavlov. Cond. response bias	0.7	0.8	2.0	-0.5	-0.9	-1.0	0.1	1.4
Pavlov. Cond. lever latency	3.4	4.7	9.3	2.0	1.3	3.1	-2.8	0.7
Pavlov. Cond. magazine entry latency	3.1	3.7	7.2	-2.2	-1.9	-2.7	1.7	0.3
Pavlov. Cond. change in total contacts	3.1	5.0	10.2	-2.0	-1.7	-3.2	2.9	-0.1
Pavlov. Cond. index score	5.0	6.7	13.1	-2.6	-1.9	-3.6	3.1	-0.4
Pavlov. Cond. latency score	4.1	5.5	10.7	-2.3	-1.7	-3.3	2.9	-0.4
Pavlov. Cond. lever contacts	4.5	6.3	12.4	-2.2	-1.5	-3.5	3.3	-1.0
Pavlov. Cond. magazine entry number	2.9	3.6	6.7	2.2	1.6	2.6	-1.9	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.4	0.5	0.2	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.5	12.4	-2.6	-1.9	-3.5	3.1	-0.4
Pavlov. Cond. response bias	4.9	6.7	13.8	-2.5	-1.8	-3.7	3.2	-0.6
Time in closed arm before self-admin	0.3	0.4	0.6	0.8	0.7	-0.1	0.6	-0.6
Time in closed arm after self-admin	1.3	1.4	2.7	1.0	1.6	1.4	-0.8	-0.7
Time in open arm before self-admin	0.9	1.0	3.3	0.3	0.0	1.1	-1.8	0.6
Time in open arm after self-admin	3.3	3.6	5.8	-1.9	-2.4	-2.3	1.3	1.3
Bone: periosteal estimation	3.9	8.3	15.6	3.6	4.0	2.4	0.1	-2.7
Bone: periosteal perimeter	1.8	3.1	6.1	2.4	2.5	1.3	0.5	-1.4
Bone: post-yield work	1.3	1.9	4.6	0.9	1.7	0.4	1.2	-2.1
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	-0.0	0.5	0.7	-0.5	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	-0.0	0.5	0.7	-0.4	0.0
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.0	-0.8	-0.7	-0.6	-0.5	1.0
Progressive ratio test 2 active lever presses	0.6	0.7	1.3	0.6	1.0	1.1	-0.7	-0.4
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	0.6	1.1	1.2	-0.7	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.3	0.3	0.5	-0.7	0.2
Incentive Sensitization - Responses	0.2	0.3	0.6	0.5	0.7	0.6	-0.0	-0.5
Incentive Sensitization - Breakpoint	0.3	0.4	0.7	0.6	0.8	0.7	-0.1	-0.6
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.4	-0.6	-0.4	-0.2	-0.0	0.4
Progressive ratio	0.2	0.3	1.4	0.1	0.0	0.0	-1.2	0.4
Food seeking constrained by brief footshock	0.7	0.9	1.4	-0.8	-1.0	-1.2	1.0	0.7
Seeking ratio, punishment vs. effort	0.3	0.5	2.0	-0.0	-0.2	-0.5	1.4	0.2
Retroperitoneal fat weight	4.4	18.7	29.9	-5.0	-5.5	-4.3	0.8	4.5
Reaction time number correct	0.2	0.5	1.5	0.1	-0.4	0.7	-1.2	0.4
Reaction time mean minus median	0.4	0.9	3.0	-0.1	0.3	-0.8	1.7	-1.0
Reaction time mean minus median AUC	0.2	0.4	1.3	-0.3	0.1	-0.6	1.2	-0.5
Reaction time num false alarms	6.9	9.7	15.0	3.9	3.2	3.7	-3.1	-0.5
Reaction time num false alarms AUC	5.2	8.2	12.0	3.5	3.0	3.4	-2.8	-0.9
Reaction time trials correct on left	0.2	0.5	1.5	0.1	-0.4	0.7	-1.2	0.4
Reaction time trials on left	0.3	0.5	1.6	0.1	-0.3	0.8	-1.3	0.3
Reaction time mean	0.1	0.2	0.6	-0.3	-0.4	-0.8	0.4	0.2
Reaction time mean AUC	0.3	0.5	1.2	-0.5	-0.6	-1.1	0.7	0.3
Median of all reaction times	0.1	0.2	0.3	-0.2	-0.5	-0.5	-0.2	0.6
Reaction time omissions	0.2	0.2	0.7	0.5	0.5	0.0	0.0	-0.8
Reaction time false alarm rate	3.5	4.8	7.6	2.8	2.5	2.5	-1.9	-0.7
Reaction time premature initiation rate	0.5	0.6	1.4	-0.0	-0.2	-1.2	1.1	-0.7
Reaction time premature initiations	0.1	0.2	0.5	-0.2	-0.5	-0.7	0.2	-0.2
Std. dev. reaction times	0.8	1.4	3.8	-0.6	-0.1	-1.4	1.9	-1.0
Reaction time trials completed	0.3	0.5	1.6	0.1	-0.3	0.8	-1.3	0.3
Reaction time trials AUC	0.3	0.6	2.1	0.1	-0.4	0.8	-1.4	0.5
Run reversals in cocaine runway, females	1.9	1.9	3.6	1.7	1.9	1.2	-0.4	-1.2
Run reversals in cocaine runway, males	5.6	5.7	8.4	-2.9	-2.8	-2.4	0.7	2.5
Latency to leave start box in cocaine runway	3.8	4.4	8.6	2.9	2.4	1.7	0.7	-2.0
Latency to leave start box in cocaine runway, F	3.8	4.4	7.9	2.8	2.5	1.9	0.1	-2.0
Latency to leave start box in cocaine runway, M	1.0	0.9	1.8	1.4	1.0	0.6	0.7	-0.9
Std. dev. time between licks in bursts	2.5	3.4	5.8	2.3	2.4	1.5	0.1	-1.8
Total sessions with >9 infusions	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.2	0.6
Short access day 1 total inactive lever presses	0.7	1.0	1.7	-0.8	-1.0	-0.8	-0.8	1.3
Short access day 10 total inactive lever presses	0.6	1.5	2.4	-0.8	-1.5	-1.2	-0.9	1.5
Short access day 1 total infusions	0.1	0.2	0.6	-0.2	-0.3	0.1	-0.5	0.8
Short access day 10 total infusions	0.0	0.0	0.0	-0.2	0.1	0.1	0.2	0.2
Short access total infusions	0.2	0.2	0.5	-0.5	-0.4	-0.2	-0.1	0.7
Short access day 1 locomotion	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.1	0.6
Short access day 10 total locomotion	0.3	0.5	1.2	0.6	1.1	0.9	-0.1	-0.6
Short access total locomotion	0.4	0.4	1.0	0.7	1.0	0.6	0.1	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.5	-0.1	0.0	-0.0	0.5
Compulsive drug intake	0.8	0.9	1.8	-0.8	-1.3	-1.1	0.3	0.9
One hour access (shock baseline)	0.3	0.5	1.1	0.4	1.0	1.0	-0.4	-0.4
Social response proportion	0.6	0.6	1.4	-1.2	-1.0	-0.2	-0.3	0.8
Social responses	0.4	0.5	0.8	0.2	0.9	0.9	-0.2	-0.8
Social time	2.9	4.0	7.6	1.8	2.7	1.4	0.9	-2.5
Soleus weight	1.0	3.0	5.0	-1.6	-1.9	-2.2	1.4	1.4
Bone: stiffness	1.5	2.5	5.3	2.0	2.3	1.2	-0.2	-1.2
Tibialis anterior weight	0.6	1.9	3.2	-1.4	-1.8	-1.5	0.8	1.2
Time to tail flick, vehicle, before self-admin	0.9	1.0	2.2	-0.5	-0.9	-0.2	-1.5	1.2
Time to tail flick, vehicle, after self-admin	3.5	4.7	7.6	2.2	2.8	1.6	0.9	-2.7
Time to tail flick, test, before self-admin	2.7	2.8	6.3	0.9	1.4	0.3	2.5	-2.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	0.2	0.1	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	5.5	5.3	10.1	1.3	2.3	0.6	3.0	-3.2
Delta time to tail flick, test, before/after SA	1.5	1.6	4.6	-0.4	-0.6	0.2	-2.1	1.6
Tibia length	1.4	3.8	10.0	1.1	2.0	0.5	1.9	-3.2
Ambulatory time before self-admin	1.0	1.5	3.0	-1.1	-1.5	-1.7	0.8	0.7
Ambulatory time after self-admin	0.8	1.0	2.9	1.7	0.8	0.4	0.1	-1.0
Bone: tissue strength	1.0	1.0	2.1	-0.8	-0.1	-1.0	1.5	-1.2
Total heroin consumption	0.5	0.6	1.0	-0.5	-1.0	-0.7	1.0	0.6
Bone: trabecular number	3.5	5.8	8.9	3.0	2.8	2.8	-1.9	-1.1
Bone: trabecular spacing	2.7	3.6	5.4	-2.3	-2.0	-2.3	1.7	0.2
Bone: trabecular thickness	0.2	0.3	0.3	0.5	0.5	0.6	-0.4	0.6
Bone: trabecular tissue density	0.9	1.3	3.2	0.6	0.9	-0.4	1.8	-1.3
Water consumed over 24 hours	0.2	0.2	0.5	0.0	-0.7	-0.6	-0.3	0.3
Number of responses in last shaping day	0.4	0.4	1.4	0.2	-0.1	0.4	-1.2	0.5