LOC102555574

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability LOC102555574 0.02 0.02 2.4e-03 0.02 0.02 0.02 0.02 1.2e-03 1.8e-03 4.2e-03 2.4e-03
2 BLA mRNA stability LOC102555574 0.06 0.06 3.3e-03 0.04 0.03 0.03 0.03 2.7e-03 9.6e-03 1.2e-02 9.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density8.414.118.84.33.1
Area under the delay curve0.80.80.91.00.8
BMI with tail3.611.612.93.63.2
BMI without tail0.00.00.1-0.30.1
Body weight5.523.224.24.94.7
Weight adjusted by age3.03.44.81.42.2
Bone surface10.318.222.74.83.7
Bone volume7.612.916.84.13.0
Breakpoint value in progressive ratio session0.20.20.20.40.5
Number of licking bursts0.30.40.6-0.80.4
Context. condit. distance diff. score0.30.40.50.50.7
Locomotion velocity, session 10.80.91.1-1.1-0.8
Locomotion distance, session 13.44.45.3-1.9-2.3
Locomotion velocity, session 20.30.30.5-0.4-0.7
Locomotion distance, session 22.63.74.5-1.7-2.1
Locomotion velocity, session 33.94.54.8-2.1-2.2
Locomotion distance, session 34.95.46.0-2.2-2.4
Stereotopy head waving bouts, day 31.72.02.21.31.5
Stereotopy head waving duration, day 30.70.90.90.91.0
Locomotion velocity, session 70.10.10.1-0.4-0.2
Locomotion distance, session 71.21.51.9-1.4-1.1
Stereotopy head waving bouts, day 71.61.82.51.11.6
Stereotopy head waving duration, day 71.72.12.81.21.7
Locomotion velocity, session 80.00.00.0-0.00.0
Locomotion distance, session 81.42.12.6-1.3-1.6
Degree of sensitization distance0.70.70.90.70.9
Degree of sensitization stereotypy0.60.61.10.31.0
Conditioned locomotion0.30.40.70.20.8
Cocaine response after cond. corrected0.40.40.8-0.0-0.9
Cocaine response after cond. not corrected1.31.42.3-0.7-1.5
Cocaine response before conditioning2.83.44.1-2.0-1.7
Saline control response0.10.10.20.50.2
Bone: connectivity density5.89.112.83.62.3
Bone: cortical apparent density0.10.10.2-0.5-0.2
Bone: cortical area8.813.314.23.83.5
Bone: cortical porosity0.70.70.8-0.8-0.9
Bone: cortical porosity1.01.11.2-1.0-1.1
Bone: cortical thickness3.25.25.22.32.3
Bone: cortical thickness0.10.10.10.30.4
Bone: cortical tissue density0.20.20.3-0.6-0.3
Condit. Reinf. active minus inactive responses0.10.10.3-0.2-0.5
Condit. Reinf. active-inactive response ratio0.20.20.30.60.0
Condit. Reinf. active responses0.60.70.8-0.8-0.9
Condit. Reinf. inactive responses2.42.83.4-1.9-1.5
Incentive salience index mean0.00.00.00.10.1
Condit. Reinf. lever presses0.20.20.30.30.6
Condit. Reinf. active minus inactive responses0.00.00.0-0.1-0.0
Condit. Reinf. active-inactive response ratio0.30.30.4-0.6-0.5
Condit. Reinf. active responses0.10.10.2-0.4-0.4
Condit. Reinf. inactive responses0.40.40.6-0.8-0.5
Condit. Reinf. lever presses0.00.00.00.10.1
Condit. Reinf. lever reinforcers received0.40.50.6-0.8-0.7
Conditioned reinforcement - actives1.51.52.1-1.5-0.9
Conditioned reinforcement - inactives2.12.43.0-1.7-1.3
Conditioned locomotion0.30.40.8-0.9-0.2
Patch foraging indifference point 0 sec2.23.53.9-2.0-1.8
Patch foraging indifference point AUC0.20.20.3-0.5-0.2
Delay disc. indifference point, 0s delay1.31.41.51.11.2
Delay disc. indifference point, 16s delay0.90.91.20.81.1
Delay disc. indifference point, 2s delay1.51.61.81.41.2
Delay disc. indifference point, 24s delay1.41.31.61.11.2
Delay disc. indifference point, 4s delay0.20.20.40.60.1
Delay disc. indifference point, 8s delay2.12.22.41.51.4
Indifference point function ln k3.54.95.62.42.1
Indifference point function log k3.54.95.62.42.1
Patch foraging total patch changes 0 sec2.03.33.7-1.9-1.7
Patch foraging total patch changes 12 sec1.72.23.3-1.8-1.0
Patch foraging total patch changes 18 sec3.54.55.3-2.3-1.9
Patch foraging total patch changes 24 sec1.51.82.7-1.6-0.9
Patch foraging total patch changes 6 sec2.33.43.9-2.0-1.7
Patch foraging time to switch 0 sec1.92.93.3-1.8-1.6
Patch foraging water rate 0 sec2.84.54.62.12.1
Patch foraging water rate 12 sec3.65.46.22.52.2
Patch foraging water rate 18 sec0.30.40.50.50.7
Patch foraging water rate 24 sec3.85.35.92.22.4
Patch foraging water rate 6 sec3.85.65.72.42.4
Seeking ratio, delayed vs. immediate footshock0.10.10.30.50.0
Distance traveled before self-admin0.70.81.1-1.1-0.6
Distance traveled after self-admin0.20.30.4-0.4-0.6
Extensor digitorum longus weight4.116.118.93.64.3
Bone: elastic displacement4.04.54.7-2.2-2.1
Bone: elastic work0.00.00.00.2-0.1
Bone: endosteal estimation7.516.317.84.23.9
Bone: endosteal perimeter6.714.014.23.73.8
Epididymis fat weight0.10.30.50.70.2
Delta time in closed arm before/after self-admin0.10.10.30.5-0.1
Delta time in open arm before/after self-admin3.63.44.4-2.1-1.6
Diff in mean of infusions in LGA sessions1.21.31.71.31.0
Delay discount exponential model param0.70.70.8-0.9-0.8
Extinction: sum of active levers before priming0.40.40.40.70.6
Active lever presses in extinction session 60.30.30.40.60.5
Bone: final force8.714.016.74.13.4
Bone: final moment9.014.618.14.33.3
Food consumed during 24 hour testing period1.31.62.31.51.0
Glucose0.20.20.40.10.7
Heart weight0.00.00.00.2-0.2
Delay discount hyperbolic model param0.70.70.9-0.9-0.7
Intermittent access intake day 1-15 change1.41.41.6-1.3-1.1
Intermittent access intake escalation1.11.11.1-1.1-1.0
Intermittent access intake escalation 21.61.61.8-1.4-1.2
Intermitt. access day 1 inactive lever presses2.02.12.6-1.6-1.3
Intermitt. access day 15 inactive lever presses1.01.11.3-1.2-0.9
Intermitt. access escalation Index0.10.10.1-0.3-0.1
Intermittent access day 1 total infusions1.21.41.7-1.3-1.1
Intermittent access day 15 total infusions2.42.73.6-1.9-1.4
Intermittent access terminal intake (last 3 days)2.83.03.7-1.9-1.5
Intermittent access total infusions2.52.83.5-1.9-1.4
Intermittent access day 1 locomotion0.60.61.0-1.0-0.4
Intermittent access day 15 total locomotion1.31.42.5-1.6-0.5
Intermittent access total locomotion2.52.94.7-2.2-1.1
Intermittent access standard deviation0.50.60.7-0.8-0.7
Left kidney weight0.20.50.91.00.1
Right kidney weight2.36.56.82.62.5
Cocaine induced anxiety1.21.41.71.11.3
Post-drug Anxiety4.85.35.72.42.2
Baseline Anxiety0.70.81.01.00.8
Tail length0.10.20.3-0.6-0.3
Length with tail1.86.47.12.72.4
Length without tail6.414.116.64.13.4
Times rat made contact with spout0.10.10.2-0.4-0.4
Lifetime Intake2.42.73.6-1.9-1.3
Liver weight, left1.72.72.71.61.6
Liver weight, right1.42.42.41.61.5
Locomotor activity0.81.22.0-1.4-0.7
Locomotor testing distance2.33.85.0-2.2-1.6
Locomotor testing rearing1.62.43.7-1.9-1.1
Locomotion in novel chamber0.70.80.90.81.0
Locomotion in novel chamber post-restriction0.10.10.10.20.3
Fecal boli incidents, locomotor time 13.03.34.1-1.6-2.0
Change in fecal boli incidents, locomotor task1.61.51.61.21.2
Time >=10cm from walls, locomotor time 10.10.10.20.40.1
Bouts of movement, locomotor time 10.00.00.0-0.1-0.2
Total resting periods, locomotor time 10.40.40.5-0.6-0.7
Rest time, locomotor task time 10.50.50.5-0.7-0.7
Distance moved, locomotor task time 10.10.10.10.30.2
Vertical activity count, locomotor time 11.01.11.51.20.8
Time >=10cm from walls, locomotor time 20.50.50.7-0.8-0.6
Bouts of movement, locomotor time 22.72.93.41.61.9
Total resting periods, locomotor time 23.13.33.81.71.9
Rest time, locomotor task time 20.00.00.00.10.0
Distance moved, locomotor task time 20.00.10.1-0.2-0.2
Vertical activity count, locomotor time 20.00.00.10.10.3
Light reinforcement 11.93.55.2-2.3-1.4
Light reinforcement 20.70.91.4-1.2-0.7
Bone: marrow area7.416.117.34.23.9
Bone: maximum diameter3.76.97.42.52.7
Bone: maximum force12.922.226.45.14.3
Bone: maximum moment13.222.727.95.34.2
Mean time between licks in bursts0.10.10.1-0.1-0.4
Mean num. licks in bursts0.50.51.10.1-1.0
Cd content in liver0.50.60.8-0.9-0.5
Co content in liver0.50.61.2-1.1-0.1
Cu content in liver0.70.81.20.71.1
Fe content in liver0.30.40.6-0.8-0.3
K content in liver0.20.20.30.30.5
Mg content in liver0.00.00.0-0.1-0.1
Mn content in liver0.10.10.20.40.2
Na content in liver0.10.10.1-0.30.2
Rb content in liver0.30.30.6-0.8-0.2
Se content in liver0.60.70.7-0.9-0.9
Sr content in liver0.50.40.60.50.8
Zn content in liver1.41.52.5-1.6-0.8
Bone: minimum diameter9.117.117.24.14.1
Time in familiar zone, hab. session 10.50.50.7-0.5-0.9
Time in novel zone, hab. session 10.70.71.10.51.0
Total zone transitions, hab. session 10.30.40.5-0.7-0.5
Total locomotion distance, hab. session 10.00.00.10.2-0.2
Locomotion velocity, hab. session 10.00.10.10.3-0.0
Time in familiar zone, hab. session 20.20.20.30.6-0.0
Time in novel zone, hab. session 20.20.20.2-0.50.3
Total zone transitions, hab. session 20.40.60.7-0.6-0.9
Total locomotion distance, hab. session 20.20.30.5-0.1-0.7
Locomotion velocity, hab. session 20.10.20.30.1-0.6
Novel to familiar place preference ratio2.22.32.91.31.7
Novelty place preference1.71.82.31.11.5
Time in novel zone, NPP test1.51.62.21.01.5
Total zone transitions, NPP test1.52.22.5-1.4-1.6
Total locomotion distance, NPP test1.82.43.1-1.3-1.8
Locomotion velocity, NPP test1.01.52.0-1.0-1.4
Intraocular pressure6.89.410.7-3.3-2.9
Delta distance traveled before/after self-admin0.10.10.10.3-0.3
Delta ambulatory time before/after self-admin0.00.00.00.0-0.2
Parametrial fat weight2.24.44.5-2.1-2.1
Pavlov. Cond. lever latency0.10.10.20.4-0.0
Pavlov. Cond. magazine entry latency0.00.10.10.0-0.3
Pavlov. Cond. change in total contacts0.00.10.10.00.3
Pavlov. Cond. index score0.10.10.20.00.4
Pavlov. Cond. latency score0.00.10.1-0.00.3
Pavlov. Cond. lever contacts0.40.50.8-0.9-0.4
Pavlov. Cond. magazine entry number0.00.00.00.20.1
Pavlov. Cond. intertrial magazine entries0.50.60.9-0.6-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.40.30.6
Pavlov. Cond. response bias0.10.10.1-0.3-0.4
Pavlov. Cond. lever latency0.00.00.00.1-0.1
Pavlov. Cond. magazine entry latency1.01.11.31.11.0
Pavlov. Cond. change in total contacts1.31.81.91.31.4
Pavlov. Cond. index score0.50.60.70.80.8
Pavlov. Cond. latency score0.50.60.60.80.8
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3
Pavlov. Cond. magazine entry number2.32.83.1-1.6-1.8
Pavlov. Cond. intertrial magazine entries4.86.36.8-2.6-2.4
Pavlov. Cond. lever-magazine prob. diff.1.01.21.41.01.2
Pavlov. Cond. response bias0.00.00.0-0.10.1
Time in closed arm before self-admin1.92.12.71.21.7
Time in closed arm after self-admin0.60.60.70.90.7
Time in open arm before self-admin0.60.70.80.90.8
Time in open arm after self-admin0.20.20.3-0.6-0.3
Bone: periosteal estimation11.223.224.95.04.6
Bone: periosteal perimeter9.115.116.94.13.7
Bone: post-yield work8.411.512.33.53.3
Progressive ratio test 1 active lever presses3.84.05.6-2.4-1.5
Progressive ratio test 1 breakpoint3.53.65.3-2.3-1.4
Progressive ratio test 1 inactive lever presses3.23.54.7-2.2-1.5
Progressive ratio test 2 active lever presses1.92.03.2-1.8-0.9
Progressive ratio test 2 breakpoint2.42.74.1-2.0-1.2
Progressive ratio test 2 inactive lever presses2.32.63.6-1.9-1.3
Incentive Sensitization - Responses0.10.10.1-0.10.3
Incentive Sensitization - Breakpoint0.00.00.1-0.20.2
Sum of active levers in priming session hrs 5-60.10.10.2-0.2-0.4
Progressive ratio0.10.10.2-0.2-0.4
Food seeking constrained by brief footshock0.40.50.6-0.8-0.5
Seeking ratio, punishment vs. effort0.00.00.0-0.10.2
Retroperitoneal fat weight0.51.81.8-1.3-1.3
Reaction time number correct1.42.02.81.71.1
Reaction time mean minus median8.811.712.0-3.4-3.5
Reaction time mean minus median AUC6.38.28.6-2.8-2.9
Reaction time num false alarms1.72.42.8-1.4-1.7
Reaction time num false alarms AUC2.73.74.6-1.7-2.1
Reaction time trials correct on left1.42.02.81.71.1
Reaction time trials on left1.11.62.31.50.9
Reaction time mean0.60.81.0-1.0-0.8
Reaction time mean AUC0.40.50.6-0.7-0.6
Median of all reaction times0.00.00.10.10.2
Reaction time omissions9.813.413.7-3.7-3.6
Reaction time false alarm rate2.94.14.3-2.0-2.1
Reaction time premature initiation rate5.47.310.1-3.2-2.1
Reaction time premature initiations2.33.34.5-2.1-1.4
Std. dev. reaction times6.38.99.0-3.0-3.0
Reaction time trials completed1.11.62.31.50.9
Reaction time trials AUC1.82.63.51.91.3
Run reversals in cocaine runway, females0.00.00.0-0.10.1
Run reversals in cocaine runway, males1.31.31.5-1.2-1.0
Latency to leave start box in cocaine runway0.00.00.1-0.1-0.2
Latency to leave start box in cocaine runway, F1.51.61.8-1.3-1.2
Latency to leave start box in cocaine runway, M1.41.41.91.40.9
Std. dev. time between licks in bursts0.70.81.2-1.1-0.6
Total sessions with >9 infusions0.80.91.6-1.3-0.5
Short access day 1 total inactive lever presses1.31.42.0-1.4-0.9
Short access day 10 total inactive lever presses0.10.10.1-0.4-0.2
Short access day 1 total infusions0.10.10.2-0.40.1
Short access day 10 total infusions1.01.11.6-1.3-0.8
Short access total infusions0.50.61.1-1.0-0.3
Short access day 1 locomotion0.20.20.3-0.50.3
Short access day 10 total locomotion0.10.10.2-0.40.2
Short access total locomotion0.40.40.7-0.90.1
One hour access (0.3 mA shock)0.30.30.6-0.8-0.3
Compulsive drug intake0.90.91.31.20.6
One hour access (shock baseline)0.20.30.5-0.7-0.1
Social response proportion0.10.20.2-0.5-0.3
Social responses6.88.710.7-3.3-2.6
Social time0.20.30.5-0.2-0.7
Soleus weight0.61.81.91.31.4
Bone: stiffness15.524.528.45.34.5
Tibialis anterior weight1.34.46.91.42.6
Time to tail flick, vehicle, before self-admin1.21.21.5-0.9-1.2
Time to tail flick, vehicle, after self-admin0.50.60.90.51.0
Time to tail flick, test, before self-admin0.50.50.5-0.6-0.7
Time to tail flick, test, after self-admin0.10.10.20.40.2
Delta time to tail flick, vehicle, before/after SA0.60.60.80.60.9
Delta time to tail flick, test, before/after SA0.20.20.20.40.4
Tibia length7.119.920.44.54.4
Ambulatory time before self-admin3.13.24.1-2.0-1.5
Ambulatory time after self-admin1.41.52.0-1.4-1.0
Bone: tissue strength1.01.01.41.20.8
Total heroin consumption2.73.14.41.42.1
Bone: trabecular number4.77.411.93.41.7
Bone: trabecular spacing1.62.13.7-1.9-0.6
Bone: trabecular thickness0.20.20.4-0.3-0.6
Bone: trabecular tissue density0.00.00.0-0.20.2
Water consumed over 24 hours0.00.00.00.2-0.1
Number of responses in last shaping day0.30.30.60.00.8