Hub : Genes

LOC102553493

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102553493	0.07	0.04	5.6e-07	0.04	0.05	0.05	0.05	7.9e-05	3.9e-06	2.1e-06	4.1e-06
2	Liver	intron excision ratio	chr15_38096688_38097670	0.03	0.02	8.1e-03	0.01	0.01	0.01	0.01	6.9e-02	8.3e-03	4.5e-02	2.9e-02
3	Adipose	gene expression	LOC102553493	0.07	0.04	8.9e-09	0.06	0.07	0.06	0.06	1.7e-07	3.2e-08	2.6e-07	1.7e-07
4	Brain	mRNA stability	LOC102553493	0.06	0.04	1.3e-03	0.02	0.01	0.01	0.01	4.4e-03	2.5e-02	8.4e-02	3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.5	2.5	3.9	1.1	-1.6	1.5	-2.0
Area under the delay curve	5.9	6.3	10.1	-3.2	3.2	-0.2	2.2
BMI with tail	1.1	3.6	7.5	-2.7	2.4	0.4	1.1
BMI without tail	0.1	0.3	0.6	0.6	-0.3	-0.8	-0.1
Body weight	0.9	3.9	8.0	-2.8	2.0	1.9	0.3
Weight adjusted by age	1.1	1.3	4.6	-0.2	-0.1	2.1	-0.7
Bone surface	0.9	1.6	2.4	0.8	-1.2	1.4	-1.6
Bone volume	0.4	0.7	1.3	0.3	-0.7	1.1	-1.0
Breakpoint value in progressive ratio session	0.6	0.7	1.1	-0.8	1.0	-0.7	0.7
Number of licking bursts	0.7	0.8	1.0	-1.0	1.0	-0.7	0.9
Context. condit. distance diff. score	1.4	1.7	4.4	0.5	0.3	-2.1	1.5
Locomotion velocity, session 1	0.3	0.3	0.7	-0.6	0.1	0.8	-0.4
Locomotion distance, session 1	0.5	0.7	1.3	0.1	-0.6	1.1	-1.1
Locomotion velocity, session 2	0.5	0.5	1.0	-1.0	0.4	1.0	-0.3
Locomotion distance, session 2	1.6	2.2	3.9	0.3	-1.3	1.8	-2.0
Locomotion velocity, session 3	0.6	0.7	1.2	-0.8	0.2	1.1	-0.9
Locomotion distance, session 3	0.3	0.3	0.7	-0.8	0.6	0.2	0.0
Stereotopy head waving bouts, day 3	0.6	0.7	1.2	1.0	-1.1	-0.0	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.2	-0.1	0.6	-0.7
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.3
Locomotion distance, session 7	0.9	1.1	1.7	1.3	-1.0	-1.3	-0.2
Stereotopy head waving bouts, day 7	1.0	1.1	2.0	-1.3	0.7	1.4	-0.4
Stereotopy head waving duration, day 7	1.1	1.3	2.1	-1.4	1.0	1.4	-0.0
Locomotion velocity, session 8	0.2	0.2	0.5	-0.7	0.5	0.2	0.3
Locomotion distance, session 8	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.2
Degree of sensitization distance	2.6	2.6	4.5	2.1	-1.6	-1.8	-0.2
Degree of sensitization stereotypy	1.1	1.2	2.2	-1.5	1.2	1.0	0.4
Conditioned locomotion	0.4	0.5	1.1	0.5	0.2	-0.9	1.0
Cocaine response after cond. corrected	4.0	4.5	7.6	-0.1	1.6	-2.8	2.8
Cocaine response after cond. not corrected	3.4	3.7	6.2	-0.2	1.5	-2.5	2.5
Cocaine response before conditioning	0.9	1.1	2.4	-0.3	-0.6	1.6	-1.2
Saline control response	0.2	0.2	0.6	0.2	-0.4	-0.0	-0.7
Bone: connectivity density	3.4	5.3	7.3	2.2	-2.7	1.5	-2.6
Bone: cortical apparent density	1.5	1.9	3.3	-0.2	1.1	-1.8	1.7
Bone: cortical area	1.4	2.1	3.3	-1.5	1.8	-0.5	1.5
Bone: cortical porosity	1.3	1.4	2.8	-1.7	1.2	1.2	0.1
Bone: cortical porosity	0.8	0.9	1.7	-1.3	1.1	0.8	0.2
Bone: cortical thickness	2.3	3.8	6.0	-2.2	2.5	-0.8	1.9
Bone: cortical thickness	3.9	4.5	5.7	-2.0	2.4	-1.7	2.4
Bone: cortical tissue density	1.4	1.9	3.4	-0.2	1.1	-1.8	1.7
Condit. Reinf. active minus inactive responses	1.1	1.2	2.9	-0.5	-0.3	1.7	-1.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.5	-0.5	0.1	-0.6
Condit. Reinf. active responses	0.9	1.1	2.7	-0.8	-0.0	1.7	-1.1
Condit. Reinf. inactive responses	0.3	0.3	0.9	-0.5	0.1	0.9	-0.4
Incentive salience index mean	2.0	2.4	5.3	-1.8	0.6	2.3	-0.8
Condit. Reinf. lever presses	2.3	3.0	5.6	-2.4	1.2	2.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.3	-0.3	-0.4	0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.3
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.3	-0.4	0.2
Condit. Reinf. inactive responses	0.4	0.5	1.1	1.1	-0.8	-0.6	-0.1
Condit. Reinf. lever presses	1.5	2.0	4.1	-0.1	-1.1	2.0	-1.7
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0
Conditioned reinforcement - actives	5.1	5.1	10.9	3.3	-2.4	-1.9	-0.3
Conditioned reinforcement - inactives	2.2	2.5	3.4	1.8	-1.8	-0.1	-1.8
Conditioned locomotion	2.6	3.1	7.9	1.4	-0.2	-2.8	1.6
Patch foraging indifference point 0 sec	0.5	0.7	1.9	0.1	-0.6	1.4	-0.8
Patch foraging indifference point AUC	1.3	1.4	4.2	0.1	0.7	-2.1	1.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.4	0.4	0.0	0.1
Delay disc. indifference point, 16s delay	5.2	5.3	8.3	-2.3	2.9	-1.0	2.6
Delay disc. indifference point, 2s delay	0.5	0.6	1.2	-1.1	0.9	0.1	0.4
Delay disc. indifference point, 24s delay	5.2	5.0	9.1	-2.6	3.0	-0.9	1.7
Delay disc. indifference point, 4s delay	4.0	4.2	7.7	-2.8	2.5	0.6	1.6
Delay disc. indifference point, 8s delay	6.4	6.6	10.7	-3.3	3.2	-0.0	2.3
Indifference point function ln k	0.7	1.0	3.1	-0.8	0.5	1.8	0.1
Indifference point function log k	0.7	1.0	3.1	-0.8	0.5	1.8	0.1
Patch foraging total patch changes 0 sec	0.3	0.5	1.9	-0.2	-0.1	1.4	-0.4
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.3	0.0	0.1	-0.3
Patch foraging total patch changes 18 sec	0.6	0.8	1.9	0.7	-0.0	-1.4	0.9
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.0	-0.0	-0.2	-0.1
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.1	-0.4	0.1	-0.5
Patch foraging water rate 0 sec	0.5	0.7	1.4	-0.8	1.2	0.6	0.8
Patch foraging water rate 12 sec	0.3	0.4	0.6	-0.6	0.8	0.6	0.6
Patch foraging water rate 18 sec	2.0	2.6	3.6	-1.9	1.9	1.0	1.5
Patch foraging water rate 24 sec	0.3	0.4	0.9	-0.4	0.6	0.0	0.9
Patch foraging water rate 6 sec	0.4	0.6	1.3	-0.5	1.1	0.3	0.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.2	0.0	0.5	0.5
Distance traveled before self-admin	0.1	0.1	0.4	0.6	-0.3	0.1	-0.1
Distance traveled after self-admin	0.2	0.2	0.4	0.3	0.2	-0.5	0.6
Extensor digitorum longus weight	4.5	17.8	30.4	-5.5	5.2	1.6	3.4
Bone: elastic displacement	0.3	0.3	0.4	0.6	-0.6	-0.2	-0.6
Bone: elastic work	0.2	0.3	0.6	-0.3	0.0	0.8	-0.6
Bone: endosteal estimation	0.2	0.4	0.7	0.4	-0.6	0.8	-0.7
Bone: endosteal perimeter	0.5	1.1	1.6	1.2	-1.3	0.8	-0.9
Epididymis fat weight	0.1	0.2	0.5	0.3	0.3	-0.7	0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	-0.3	0.4	0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.3	-0.2	-0.7	-0.5
Diff in mean of infusions in LGA sessions	1.2	1.3	2.8	-1.7	1.1	1.2	-0.1
Delay discount exponential model param	6.4	6.7	11.2	3.3	-3.3	0.1	-2.2
Extinction: sum of active levers before priming	0.2	0.2	0.7	0.3	-0.0	-0.8	0.3
Active lever presses in extinction session 6	0.2	0.2	0.4	0.5	-0.6	-0.3	-0.2
Bone: final force	1.1	1.8	2.9	-1.6	1.7	0.3	1.2
Bone: final moment	0.8	1.2	1.9	-1.4	1.4	0.7	0.8
Food consumed during 24 hour testing period	0.3	0.4	0.7	0.2	-0.4	0.8	-0.8
Glucose	0.1	0.2	0.5	-0.7	0.4	-0.4	0.2
Heart weight	0.2	0.3	0.8	0.9	-0.4	0.2	0.4
Delay discount hyperbolic model param	6.0	6.3	10.9	3.3	-3.2	-0.0	-2.1
Intermittent access intake day 1-15 change	1.3	1.3	2.1	1.2	-1.3	0.1	-1.5
Intermittent access intake escalation	1.1	1.0	1.4	1.2	-1.2	-0.3	-1.1
Intermittent access intake escalation 2	0.7	0.7	1.0	1.0	-0.9	-0.4	-1.0
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.0	1.2	-1.4	0.0	-1.2
Intermitt. access day 15 inactive lever presses	1.4	1.5	3.3	0.8	-1.0	1.1	-1.8
Intermitt. access escalation Index	0.2	0.2	0.5	0.2	-0.2	-0.7	0.1
Intermittent access day 1 total infusions	0.7	0.8	2.4	-0.0	0.3	-1.5	0.8
Intermittent access day 15 total infusions	1.1	1.3	2.4	1.2	-1.0	-1.6	-0.5
Intermittent access terminal intake (last 3 days)	0.9	1.0	2.4	0.9	-0.8	-1.5	-0.3
Intermittent access total infusions	1.1	1.2	3.8	0.6	-0.3	-2.0	0.7
Intermittent access day 1 locomotion	0.7	0.7	1.1	-0.7	0.8	-0.7	1.0
Intermittent access day 15 total locomotion	0.6	0.7	1.9	0.7	-0.4	-1.4	0.3
Intermittent access total locomotion	0.3	0.4	1.0	-0.3	0.3	-1.0	0.6
Intermittent access standard deviation	0.9	1.0	1.8	0.8	-1.2	0.0	-1.3
Left kidney weight	1.1	3.0	9.3	-1.2	0.3	3.0	-1.1
Right kidney weight	0.9	2.4	8.0	-1.1	0.5	2.8	-0.6
Cocaine induced anxiety	0.2	0.2	0.7	0.1	-0.2	0.8	-0.4
Post-drug Anxiety	2.0	2.2	4.7	0.1	-0.8	2.2	-1.8
Baseline Anxiety	0.4	0.4	0.9	-0.4	-0.0	0.8	-0.9
Tail length	0.8	2.5	4.1	2.0	-1.9	0.3	-1.5
Length with tail	0.4	1.3	3.8	-0.3	-0.3	1.9	-1.1
Length without tail	2.0	4.5	8.3	-2.9	1.9	2.4	0.4
Times rat made contact with spout	0.4	0.5	1.0	-0.3	-0.4	1.0	-0.8
Lifetime Intake	1.1	1.3	3.3	1.0	-0.6	-1.8	0.6
Liver weight, left	1.1	1.7	3.2	-1.8	1.5	1.0	0.6
Liver weight, right	0.8	1.3	2.4	-1.4	1.5	-0.2	0.7
Locomotor activity	1.6	2.5	7.1	-1.5	0.7	2.7	-0.5
Locomotor testing distance	1.5	2.5	5.5	0.4	-1.0	2.3	-1.8
Locomotor testing rearing	5.7	8.9	14.4	1.5	-2.8	3.3	-3.8
Locomotion in novel chamber	0.3	0.4	0.6	-0.8	0.6	0.7	-0.1
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	-0.7	0.2	0.5	-0.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	0.2	-0.7	0.9	-0.5
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.7	0.5	-1.3	1.6	-1.6
Bouts of movement, locomotor time 1	0.5	0.6	0.9	-0.9	0.3	0.9	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.8	-0.9	0.5	0.2	-0.3
Rest time, locomotor task time 1	0.6	0.6	1.5	-1.2	0.8	0.1	0.6
Distance moved, locomotor task time 1	0.7	0.7	1.9	1.4	-0.9	-0.4	-0.1
Vertical activity count, locomotor time 1	0.3	0.3	1.0	1.0	-0.3	-0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.4	0.7	-0.9	1.2	-1.0
Bouts of movement, locomotor time 2	2.1	2.3	4.1	-2.0	1.9	0.2	1.2
Total resting periods, locomotor time 2	2.8	3.0	5.8	-2.4	2.2	0.3	1.2
Rest time, locomotor task time 2	1.8	2.1	4.7	-2.2	1.7	-0.1	0.8
Distance moved, locomotor task time 2	0.6	0.7	2.0	1.4	-0.7	-0.4	-0.2
Vertical activity count, locomotor time 2	0.7	0.7	1.4	1.2	0.0	-1.1	0.6
Light reinforcement 1	0.1	0.3	0.7	-0.3	-0.1	0.9	-0.4
Light reinforcement 2	0.4	0.6	1.0	0.6	0.0	-1.0	1.0
Bone: marrow area	0.2	0.4	0.6	0.5	-0.6	0.8	-0.7
Bone: maximum diameter	0.7	1.2	1.8	-0.8	1.3	-0.9	1.3
Bone: maximum force	1.2	2.0	3.6	-1.8	1.9	0.2	1.2
Bone: maximum moment	0.8	1.4	2.4	-1.6	1.6	0.6	0.7
Mean time between licks in bursts	2.7	3.8	7.6	2.8	-2.4	-0.4	-1.2
Mean num. licks in bursts	1.0	1.2	1.4	0.9	-1.1	1.1	-1.2
Cd content in liver	0.8	0.9	1.2	0.9	-1.1	0.6	-1.1
Co content in liver	1.9	2.2	3.5	-1.3	1.8	-0.6	1.9
Cu content in liver	0.7	0.9	2.3	-0.9	0.1	1.5	-0.6
Fe content in liver	1.2	1.4	2.2	1.2	-1.5	0.6	-1.3
K content in liver	0.7	0.7	1.8	0.3	0.3	-1.4	0.9
Mg content in liver	0.6	0.6	1.3	0.9	-0.4	-1.2	0.3
Mn content in liver	0.6	0.7	1.6	0.9	-0.3	-1.3	0.6
Na content in liver	3.0	3.2	5.7	-2.3	1.2	2.4	-0.6
Rb content in liver	1.0	1.2	2.3	1.5	-1.3	-0.7	-0.5
Se content in liver	0.2	0.2	0.4	0.2	-0.5	0.7	-0.5
Sr content in liver	2.8	2.5	4.1	1.5	-2.0	0.6	-1.9
Zn content in liver	1.4	1.5	4.4	-1.1	0.4	2.1	-0.5
Bone: minimum diameter	0.3	0.5	0.8	-0.9	0.9	0.3	0.4
Time in familiar zone, hab. session 1	0.5	0.4	0.9	0.0	0.3	-0.8	1.0
Time in novel zone, hab. session 1	0.4	0.4	0.9	-1.0	0.7	0.2	-0.0
Total zone transitions, hab. session 1	0.4	0.6	0.9	-0.9	0.9	0.1	0.7
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.3	0.1	-0.1	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	0.0	0.5	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	1.0	0.5	0.1	-1.0	0.5
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.4	-0.3	0.8	-0.7
Total zone transitions, hab. session 2	0.5	0.6	1.5	-0.9	0.5	1.2	0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.7	-0.8	0.5	0.7	0.4
Locomotion velocity, hab. session 2	0.5	0.7	1.4	-1.2	0.7	0.9	0.4
Novel to familiar place preference ratio	0.4	0.4	0.9	0.2	-0.7	0.2	-0.9
Novelty place preference	0.7	0.7	1.5	0.2	-0.9	0.7	-1.2
Time in novel zone, NPP test	0.8	0.9	1.9	0.1	-0.9	0.8	-1.4
Total zone transitions, NPP test	0.2	0.3	1.1	-0.4	-0.0	1.1	-0.2
Total locomotion distance, NPP test	1.2	1.7	2.7	1.1	-1.6	0.9	-1.4
Locomotion velocity, NPP test	1.0	1.4	2.4	1.1	-1.6	0.8	-1.2
Intraocular pressure	4.1	5.7	8.2	2.6	-2.9	-0.2	-2.8
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.7	0.4	-0.2	0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	-0.4	0.3	-0.5	0.2
Parametrial fat weight	1.5	2.9	6.1	2.0	-1.1	-2.5	0.2
Pavlov. Cond. lever latency	1.0	1.3	2.3	1.5	-1.0	-1.3	-0.4
Pavlov. Cond. magazine entry latency	0.6	0.7	1.6	-1.0	0.5	1.3	-0.3
Pavlov. Cond. change in total contacts	2.2	2.3	4.5	-2.1	1.4	1.7	0.2
Pavlov. Cond. index score	2.4	3.0	5.2	-2.3	1.5	2.1	0.4
Pavlov. Cond. latency score	1.9	2.4	4.1	-2.0	1.2	2.0	0.2
Pavlov. Cond. lever contacts	1.7	2.0	3.8	-1.8	1.0	2.0	0.1
Pavlov. Cond. magazine entry number	1.3	1.6	2.8	1.7	-1.0	-1.6	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.2	-0.1	0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.4	6.2	-2.5	1.7	2.1	0.5
Pavlov. Cond. response bias	2.0	2.5	4.4	-2.1	1.5	1.7	0.6
Pavlov. Cond. lever latency	1.5	2.0	5.7	1.0	0.2	-2.4	1.1
Pavlov. Cond. magazine entry latency	1.3	1.5	2.8	-1.7	1.3	1.0	0.6
Pavlov. Cond. change in total contacts	1.1	1.5	2.7	-1.6	0.9	1.7	-0.2
Pavlov. Cond. index score	1.3	1.6	3.2	-1.6	0.8	1.8	-0.1
Pavlov. Cond. latency score	1.3	1.6	3.6	-1.5	0.6	1.9	-0.3
Pavlov. Cond. lever contacts	1.5	2.1	5.6	-0.8	-0.5	2.4	-1.4
Pavlov. Cond. magazine entry number	0.7	0.8	1.7	1.3	-1.0	-0.6	-0.5
Pavlov. Cond. intertrial magazine entries	5.8	7.5	12.2	3.5	-3.5	-0.2	-2.4
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.8	-1.7	0.9	1.6	0.1
Pavlov. Cond. response bias	1.2	1.7	4.1	-1.4	0.4	2.0	-0.7
Time in closed arm before self-admin	1.8	2.0	3.7	-1.9	1.5	1.3	0.7
Time in closed arm after self-admin	1.5	1.5	2.2	-1.3	1.1	1.5	1.0
Time in open arm before self-admin	1.2	1.3	2.0	1.4	-1.4	0.1	-1.0
Time in open arm after self-admin	1.5	1.6	2.2	1.4	-1.5	-0.3	-1.5
Bone: periosteal estimation	0.1	0.2	0.3	-0.4	0.6	0.0	0.4
Bone: periosteal perimeter	0.0	0.0	0.0	-0.1	0.2	0.2	0.1
Bone: post-yield work	2.9	4.0	6.3	-0.8	1.8	-2.5	2.4
Progressive ratio test 1 active lever presses	0.8	0.8	1.9	-0.4	0.5	-1.4	1.0
Progressive ratio test 1 breakpoint	0.9	0.9	2.0	-0.4	0.5	-1.4	1.1
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.6	1.3	-1.3	-0.7	-0.8
Progressive ratio test 2 active lever presses	1.7	1.8	2.3	1.5	-1.5	-1.3	-1.0
Progressive ratio test 2 breakpoint	1.3	1.5	2.2	1.3	-1.5	-0.8	-1.2
Progressive ratio test 2 inactive lever presses	1.9	2.2	3.2	1.6	-1.8	-0.5	-1.6
Incentive Sensitization - Responses	4.0	4.0	5.6	2.2	-2.4	-0.1	-2.4
Incentive Sensitization - Breakpoint	4.5	4.6	7.0	2.3	-2.5	0.1	-2.6
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.7	-0.4	-0.9	-0.1
Progressive ratio	0.0	0.1	0.1	-0.0	0.1	0.4	-0.3
Food seeking constrained by brief footshock	1.2	1.5	3.1	-0.1	0.8	-1.7	1.5
Seeking ratio, punishment vs. effort	0.7	0.8	1.5	-0.4	0.7	-1.1	1.2
Retroperitoneal fat weight	0.3	1.1	3.0	1.0	-0.3	-1.7	0.6
Reaction time number correct	0.6	0.9	1.3	1.1	-1.1	0.5	-1.0
Reaction time mean minus median	0.5	0.6	1.3	-0.3	-0.4	0.9	-1.1
Reaction time mean minus median AUC	0.5	0.7	1.5	0.0	-0.6	0.9	-1.2
Reaction time num false alarms	0.9	1.2	3.5	-0.7	-0.2	1.9	-1.0
Reaction time num false alarms AUC	0.7	0.9	2.6	-0.7	-0.0	1.6	-0.7
Reaction time trials correct on left	0.6	0.9	1.3	1.1	-1.1	0.5	-1.0
Reaction time trials on left	0.8	1.1	1.6	1.3	-1.2	0.5	-1.1
Reaction time mean	0.5	0.7	1.2	0.7	-0.9	0.3	-1.1
Reaction time mean AUC	0.5	0.6	1.2	0.6	-0.8	0.6	-1.1
Median of all reaction times	0.5	0.6	0.9	0.9	-0.9	0.1	-0.9
Reaction time omissions	3.0	4.2	6.8	2.5	-2.6	0.2	-1.9
Reaction time false alarm rate	0.6	0.9	1.8	-1.3	0.7	1.1	0.1
Reaction time premature initiation rate	0.3	0.4	0.9	-1.0	0.7	-0.0	0.2
Reaction time premature initiations	0.0	0.0	0.1	-0.3	0.1	0.1	-0.3
Std. dev. reaction times	0.3	0.5	1.1	0.4	-0.8	0.3	-1.0
Reaction time trials completed	0.8	1.1	1.6	1.3	-1.2	0.5	-1.1
Reaction time trials AUC	0.9	1.3	1.9	1.4	-1.3	0.5	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.4	-0.2	-0.1	-0.4
Run reversals in cocaine runway, males	1.9	1.8	4.1	-2.0	1.6	0.3	0.7
Latency to leave start box in cocaine runway	1.0	1.1	2.0	1.4	-1.3	0.0	-0.8
Latency to leave start box in cocaine runway, F	0.5	0.6	1.4	0.6	-0.7	0.3	-1.2
Latency to leave start box in cocaine runway, M	1.6	1.5	3.6	1.9	-1.5	-0.0	-0.5
Std. dev. time between licks in bursts	1.5	1.8	2.8	1.7	-1.7	0.2	-1.2
Total sessions with >9 infusions	0.9	1.0	1.9	1.4	-1.2	-0.9	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.3	-0.4	-0.5	-0.2
Short access day 10 total inactive lever presses	0.7	0.8	1.3	0.9	-0.9	-0.5	-1.1
Short access day 1 total infusions	1.5	1.6	2.5	1.6	-1.3	-1.5	0.3
Short access day 10 total infusions	1.0	1.2	1.9	-0.6	0.9	-1.3	1.4
Short access total infusions	0.6	0.6	1.3	0.5	-0.3	-1.1	0.9
Short access day 1 locomotion	0.5	0.5	1.0	1.0	-0.5	-0.3	0.7
Short access day 10 total locomotion	0.4	0.4	1.0	-1.0	0.5	0.6	0.0
Short access total locomotion	0.1	0.1	0.1	-0.2	-0.2	0.3	0.3
One hour access (0.3 mA shock)	0.7	0.8	2.8	0.5	-0.1	-1.7	0.1
Compulsive drug intake	0.2	0.2	0.4	-0.6	0.5	0.2	0.0
One hour access (shock baseline)	1.1	1.2	3.0	1.1	-0.8	-1.7	-0.1
Social response proportion	1.7	1.9	3.2	1.7	-1.8	-0.5	-1.1
Social responses	1.8	2.3	4.2	1.9	-2.1	-0.2	-1.2
Social time	2.9	3.8	5.8	0.7	-1.8	2.4	-2.4
Soleus weight	1.1	3.3	6.3	-1.1	2.0	-1.4	2.5
Bone: stiffness	0.9	1.5	2.3	-1.4	1.5	0.5	1.1
Tibialis anterior weight	4.3	14.6	26.6	-5.2	4.6	2.1	2.5
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.8	-1.7	1.0	1.0	-0.4
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.8	-1.3	1.0	0.2	0.3
Time to tail flick, test, before self-admin	0.8	0.7	1.9	0.2	-0.6	0.8	-1.4
Time to tail flick, test, after self-admin	2.9	3.0	5.3	2.3	-2.2	-0.5	-1.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.5	-0.4	-0.3	0.3
Delta time to tail flick, test, before/after SA	1.4	1.3	2.6	1.6	-1.3	-0.9	0.0
Tibia length	2.4	6.7	17.1	-1.2	-0.7	4.1	-2.8
Ambulatory time before self-admin	0.1	0.1	0.3	0.2	0.3	0.0	0.5
Ambulatory time after self-admin	0.6	0.7	1.4	-0.5	1.0	-0.4	1.2
Bone: tissue strength	1.1	1.1	1.7	1.1	-1.2	0.2	-1.3
Total heroin consumption	0.2	0.2	0.3	-0.5	0.5	-0.2	0.6
Bone: trabecular number	1.7	2.6	3.6	1.5	-1.8	1.1	-1.9
Bone: trabecular spacing	3.3	4.3	5.9	-1.8	2.4	-1.6	2.4
Bone: trabecular thickness	0.6	0.7	1.5	-1.0	0.5	1.2	-0.1
Bone: trabecular tissue density	1.8	2.6	4.3	-1.6	2.1	-0.5	1.7
Water consumed over 24 hours	0.6	0.8	1.5	-1.1	0.6	1.2	-0.2
Number of responses in last shaping day	0.2	0.2	0.4	0.4	-0.1	-0.7	0.4