Hub : Genes

LOC102553445

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr20_2949135_2950543	0.1	0.07	9.7e-07	0.05	0.05	0.05	0.05	3.7e-06	1.4e-06	1.8e-06	2.8e-06
2	Liver	gene expression	LOC102553445	0.46	0.14	0.0e+00	0.42	0.44	0.44	0.44	8.3e-50	7.1e-53	1.6e-53	1.9e-53
3	Brain	gene expression	LOC102553445	0.11	0.13	2.0e-04	0.06	0.04	0.04	0.05	5.8e-06	3.2e-04	8.0e-05	1.3e-05
4	Liver	intron excision ratio	chr20_2953905_2954061	0.23	0.15	8.3e-09	0.02	0.04	0.03	0.03	5.5e-03	3.3e-05	3.2e-04	2.1e-04
5	Liver	intron excision ratio	chr20_2949574_2950543	0.04	0.03	3.5e-03	0.03	0.02	0.02	0.03	1.9e-04	2.3e-03	1.4e-03	2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.5	2.6	3.0	-1.5	-1.7	1.6	1.5	1.6
Area under the delay curve	1.0	1.1	3.4	-0.1	1.8	-0.1	-1.1	-1.0
BMI with tail	0.5	1.6	6.8	-0.3	2.6	0.3	-0.9	0.6
BMI without tail	1.2	2.5	7.8	0.7	2.8	-0.3	-2.0	-0.3
Body weight	1.8	7.5	27.6	1.8	5.3	-0.5	-2.5	0.1
Weight adjusted by age	1.8	2.1	3.6	1.2	1.8	-1.3	-1.9	-0.7
Bone surface	0.2	0.4	1.1	0.7	0.2	-0.4	-1.0	-0.5
Bone volume	0.1	0.2	0.5	-0.3	0.1	0.6	-0.2	0.7
Breakpoint value in progressive ratio session	0.4	0.4	1.3	-0.0	-1.1	-0.7	-0.4	-0.4
Number of licking bursts	1.1	1.3	2.6	1.2	-0.4	-0.9	-1.3	-1.6
Context. condit. distance diff. score	2.9	3.5	8.4	1.7	-2.9	-1.8	0.8	-1.5
Locomotion velocity, session 1	0.1	0.1	0.3	0.6	-0.5	-0.1	0.1	-0.2
Locomotion distance, session 1	0.8	1.0	1.6	-1.3	-0.7	0.9	1.0	1.0
Locomotion velocity, session 2	0.3	0.3	0.9	0.6	-0.1	-1.0	-0.3	-0.5
Locomotion distance, session 2	0.3	0.4	0.7	-0.5	-0.8	0.2	0.8	0.6
Locomotion velocity, session 3	0.6	0.8	1.6	-0.9	0.2	1.3	0.5	1.0
Locomotion distance, session 3	0.9	1.0	2.2	-0.6	-1.5	0.5	1.3	0.8
Stereotopy head waving bouts, day 3	1.5	1.8	3.1	1.5	1.3	-0.4	-1.8	-1.2
Stereotopy head waving duration, day 3	1.0	1.2	2.3	1.1	1.2	-0.0	-1.5	-1.0
Locomotion velocity, session 7	1.6	1.7	5.9	-0.3	-2.4	0.1	1.6	0.3
Locomotion distance, session 7	1.4	1.8	6.0	-0.9	-2.5	-0.3	1.5	0.1
Stereotopy head waving bouts, day 7	0.7	0.8	2.5	0.3	1.6	0.8	-0.9	0.2
Stereotopy head waving duration, day 7	0.9	1.1	3.6	0.6	1.9	0.6	-1.2	0.1
Locomotion velocity, session 8	3.6	4.2	8.2	2.9	-0.5	-2.0	-1.7	-2.4
Locomotion distance, session 8	1.6	2.4	6.2	1.2	-2.5	-1.6	1.0	-0.8
Degree of sensitization distance	1.3	1.3	2.6	1.0	-0.5	-1.5	-0.7	-1.6
Degree of sensitization stereotypy	0.4	0.5	1.6	0.1	1.3	0.4	-0.7	0.4
Conditioned locomotion	0.5	0.5	0.7	0.8	0.7	-0.7	-0.9	-0.5
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.3	-0.6	-0.6	-0.1	-0.6
Cocaine response after cond. not corrected	1.3	1.5	2.4	1.1	0.4	-1.4	-1.3	-1.6
Cocaine response before conditioning	3.1	3.8	5.8	2.1	2.4	-1.0	-2.4	-1.4
Saline control response	1.9	2.5	4.0	-1.4	1.2	2.0	1.0	2.0
Bone: connectivity density	1.2	1.9	5.7	-0.7	-2.4	0.9	1.4	0.7
Bone: cortical apparent density	1.2	1.6	3.2	-1.8	0.8	1.4	0.6	1.4
Bone: cortical area	0.8	1.2	3.2	0.4	1.8	-0.4	-1.6	-0.0
Bone: cortical porosity	0.4	0.4	0.9	-0.4	0.9	-0.1	-0.9	-0.1
Bone: cortical porosity	0.9	0.9	2.2	0.6	0.9	-0.7	-1.5	-0.9
Bone: cortical thickness	1.9	3.1	5.3	-2.1	2.3	1.4	-0.5	1.9
Bone: cortical thickness	1.7	1.9	3.9	-2.0	0.9	1.3	0.6	1.7
Bone: cortical tissue density	1.0	1.3	2.6	-1.6	0.8	1.3	0.6	1.3
Condit. Reinf. active minus inactive responses	0.4	0.4	1.4	-0.1	-1.2	-0.3	0.8	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.5	0.0	-0.0	0.0	0.1
Condit. Reinf. active responses	0.8	1.0	2.5	-0.4	-1.4	-0.3	1.6	0.6
Condit. Reinf. inactive responses	2.1	2.5	5.9	-1.2	-1.7	0.5	2.4	1.5
Incentive salience index mean	1.1	1.3	2.7	1.0	-1.6	-1.4	0.5	-0.7
Condit. Reinf. lever presses	1.9	2.5	4.7	1.5	-2.1	-2.2	0.7	-0.9
Condit. Reinf. active minus inactive responses	0.9	1.1	2.2	0.7	1.4	-0.5	-1.5	-0.9
Condit. Reinf. active-inactive response ratio	2.2	2.3	4.2	1.3	1.8	-1.0	-2.0	-1.3
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.0	0.1	-0.2	-0.4
Condit. Reinf. inactive responses	1.3	1.6	3.2	-0.7	-1.5	0.9	1.8	0.9
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.2	-0.6	-0.4	0.3	-0.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.3	-0.2	-0.1	-0.3	-0.5
Conditioned reinforcement - actives	1.7	1.7	5.2	0.1	1.0	-1.1	-2.3	-1.1
Conditioned reinforcement - inactives	0.9	1.0	2.3	-0.6	1.5	0.1	-1.5	-0.2
Conditioned locomotion	0.5	0.6	1.7	0.4	0.2	-0.3	-1.3	-1.1
Patch foraging indifference point 0 sec	1.3	2.1	4.0	-1.7	0.8	2.0	0.5	1.7
Patch foraging indifference point AUC	1.2	1.4	3.3	0.6	1.7	0.1	-1.8	-0.6
Delay disc. indifference point, 0s delay	1.4	1.6	2.9	0.8	0.7	-1.0	-1.7	-1.6
Delay disc. indifference point, 16s delay	1.1	1.1	2.4	-1.6	1.5	0.7	-0.2	0.1
Delay disc. indifference point, 2s delay	2.5	2.8	5.4	1.0	1.9	-1.2	-2.3	-1.7
Delay disc. indifference point, 24s delay	0.4	0.4	1.1	-0.5	1.0	-0.5	-0.6	0.0
Delay disc. indifference point, 4s delay	1.9	2.0	4.0	1.1	2.0	-1.0	-1.2	-1.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	-0.2	0.7	0.2	-0.0	-0.3
Indifference point function ln k	0.5	0.7	1.5	0.7	-0.9	-1.2	0.3	-0.7
Indifference point function log k	0.5	0.7	1.5	0.7	-0.9	-1.2	0.3	-0.7
Patch foraging total patch changes 0 sec	1.5	2.5	4.2	-1.9	1.0	2.0	0.6	1.8
Patch foraging total patch changes 12 sec	1.1	1.4	2.5	-1.6	1.3	1.4	-0.0	1.0
Patch foraging total patch changes 18 sec	3.8	4.9	10.1	-2.7	0.5	3.2	0.9	2.4
Patch foraging total patch changes 24 sec	3.3	4.0	8.1	-2.8	-0.3	2.5	1.1	2.0
Patch foraging total patch changes 6 sec	1.9	2.9	5.2	-2.3	1.0	2.3	0.1	1.8
Patch foraging time to switch 0 sec	0.9	1.3	2.4	-1.6	-0.4	1.0	1.1	1.4
Patch foraging water rate 0 sec	0.1	0.2	0.5	-0.0	0.7	0.3	-0.2	-0.4
Patch foraging water rate 12 sec	0.6	0.9	1.7	-1.1	-0.4	0.6	1.3	1.1
Patch foraging water rate 18 sec	0.0	0.1	0.1	0.3	0.2	-0.3	-0.3	0.1
Patch foraging water rate 24 sec	0.4	0.6	2.3	-0.0	1.5	-0.8	0.1	-0.0
Patch foraging water rate 6 sec	0.5	0.8	1.3	-0.9	-0.2	1.1	1.0	0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	0.3	0.7	-0.6	-0.9	0.3
Distance traveled before self-admin	0.2	0.3	0.8	0.9	-0.3	-0.5	-0.1	-0.4
Distance traveled after self-admin	0.4	0.4	1.0	0.9	0.2	0.0	0.4	-1.0
Extensor digitorum longus weight	0.4	1.7	2.8	1.5	0.2	-1.7	-1.2	-1.4
Bone: elastic displacement	1.2	1.4	2.7	-1.1	0.3	1.7	0.9	1.5
Bone: elastic work	0.8	1.1	2.5	-0.3	1.6	1.1	-1.1	0.6
Bone: endosteal estimation	4.5	9.8	17.1	4.1	1.8	-3.0	-3.1	-3.1
Bone: endosteal perimeter	3.9	8.0	14.0	3.7	0.0	-3.4	-2.1	-3.2
Epididymis fat weight	5.3	12.5	26.3	-5.1	2.4	3.3	2.1	3.9
Delta time in closed arm before/after self-admin	0.7	0.6	1.5	0.2	0.6	-0.1	-1.1	-1.2
Delta time in open arm before/after self-admin	0.2	0.2	0.6	-0.3	-0.0	0.2	0.5	0.8
Diff in mean of infusions in LGA sessions	1.0	1.1	4.0	-1.0	-2.0	-0.2	0.7	0.3
Delay discount exponential model param	1.0	1.1	3.5	0.1	-1.9	0.2	1.0	1.0
Extinction: sum of active levers before priming	0.2	0.2	0.5	-0.4	-0.5	-0.4	-0.7	-0.3
Active lever presses in extinction session 6	0.6	0.6	1.3	-0.9	-0.1	1.1	0.9	0.0
Bone: final force	1.8	3.0	11.1	-0.5	3.3	0.3	-1.8	0.6
Bone: final moment	1.6	2.6	9.8	-0.4	3.1	0.3	-1.6	0.7
Food consumed during 24 hour testing period	0.4	0.5	1.6	1.3	0.7	-0.3	-0.5	-0.1
Glucose	6.4	9.7	17.1	3.7	-1.0	-4.1	-1.9	-3.7
Heart weight	0.6	0.8	1.8	0.5	0.5	-0.7	-1.1	-1.4
Delay discount hyperbolic model param	1.2	1.3	3.6	-0.1	-1.9	0.3	1.2	1.2
Intermittent access intake day 1-15 change	0.7	0.7	2.4	-0.1	0.7	1.5	0.3	0.8
Intermittent access intake escalation	0.3	0.3	1.3	0.5	0.2	1.1	0.2	0.2
Intermittent access intake escalation 2	0.9	0.9	3.6	1.9	-0.3	-0.2	-0.2	-0.8
Intermitt. access day 1 inactive lever presses	1.4	1.5	3.1	1.2	0.4	-1.2	-1.2	-1.8
Intermitt. access day 15 inactive lever presses	0.6	0.7	2.7	0.2	1.7	-0.1	-0.9	-0.1
Intermitt. access escalation Index	0.9	0.8	2.7	-0.2	-1.6	0.1	1.0	-0.2
Intermittent access day 1 total infusions	0.2	0.2	0.3	-0.6	-0.6	-0.1	-0.3	0.4
Intermittent access day 15 total infusions	0.2	0.2	0.5	-0.5	-0.3	0.7	0.0	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.3	0.3	0.1	-0.5	0.1
Intermittent access total infusions	0.1	0.1	0.2	-0.5	-0.1	0.1	-0.4	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.5	0.0
Intermittent access day 15 total locomotion	0.4	0.5	1.1	1.1	0.5	0.7	-0.7	-0.2
Intermittent access total locomotion	0.2	0.2	0.8	0.9	0.3	0.3	-0.4	0.4
Intermittent access standard deviation	0.8	0.8	3.0	-0.5	1.7	0.5	-0.5	0.5
Left kidney weight	1.0	2.9	12.1	0.7	3.5	-0.1	-1.3	0.3
Right kidney weight	1.0	2.8	8.8	1.7	3.0	-0.8	-1.3	-0.1
Cocaine induced anxiety	1.2	1.4	4.3	1.0	-2.1	-0.1	1.1	-0.5
Post-drug Anxiety	0.6	0.7	1.3	0.8	-1.1	-0.6	0.5	-1.0
Baseline Anxiety	0.6	0.7	1.0	-0.8	0.7	-1.0	-0.7	-0.8
Tail length	3.1	9.5	16.2	4.0	3.2	-1.7	-3.5	-2.3
Length with tail	1.9	6.9	14.1	3.3	3.8	-1.3	-2.5	-1.3
Length without tail	1.2	2.7	7.7	1.6	2.8	-1.0	-1.3	-0.7
Times rat made contact with spout	3.8	4.3	5.8	-2.1	-1.2	2.1	2.4	2.4
Lifetime Intake	0.2	0.3	1.0	-0.2	0.1	-0.4	-1.0	-0.3
Liver weight, left	0.5	0.7	2.7	1.7	0.5	-0.7	-0.4	-0.2
Liver weight, right	3.0	5.0	9.9	3.1	2.1	-1.6	-2.3	-1.7
Locomotor activity	1.5	2.4	6.7	2.6	0.9	-0.9	-1.5	-1.1
Locomotor testing distance	0.4	0.7	1.4	1.2	0.4	-0.7	-1.0	-0.6
Locomotor testing rearing	0.6	0.9	2.0	1.4	0.8	-0.2	-1.2	-0.5
Locomotion in novel chamber	0.3	0.3	0.9	0.2	1.0	0.5	0.7	0.0
Locomotion in novel chamber post-restriction	0.2	0.2	1.0	-0.3	1.0	0.2	0.2	0.3
Fecal boli incidents, locomotor time 1	0.4	0.4	1.3	-0.2	-1.1	-0.2	0.9	0.2
Change in fecal boli incidents, locomotor task	2.2	2.1	3.7	0.7	1.2	-1.6	-1.9	-1.6
Time >=10cm from walls, locomotor time 1	1.6	1.6	4.2	1.5	0.6	-0.6	-2.1	-1.0
Bouts of movement, locomotor time 1	0.8	0.9	2.1	0.6	-1.5	-0.2	1.3	0.1
Total resting periods, locomotor time 1	0.6	0.7	1.4	0.8	-1.1	-0.4	1.2	-0.1
Rest time, locomotor task time 1	0.5	0.5	1.8	1.4	-0.5	0.3	0.7	-0.1
Distance moved, locomotor task time 1	0.4	0.4	1.1	-0.6	1.1	-0.0	-0.7	0.1
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.7	0.7	0.5	-0.4	0.1
Time >=10cm from walls, locomotor time 2	1.4	1.5	4.2	1.0	0.3	-1.1	-2.0	-1.1
Bouts of movement, locomotor time 2	0.6	0.6	2.6	1.6	0.6	-0.1	-0.5	-0.2
Total resting periods, locomotor time 2	0.9	0.9	3.8	2.0	0.3	-0.4	-0.4	-0.6
Rest time, locomotor task time 2	1.6	1.8	5.9	2.4	-0.8	-1.0	0.6	-1.1
Distance moved, locomotor task time 2	0.8	0.9	2.2	-1.5	1.1	0.6	-0.8	0.5
Vertical activity count, locomotor time 2	0.2	0.3	1.0	-1.0	0.3	0.2	-0.4	0.1
Light reinforcement 1	0.4	0.8	1.3	-1.1	0.4	1.2	1.0	0.7
Light reinforcement 2	0.3	0.4	0.9	0.6	0.7	0.9	0.3	0.4
Bone: marrow area	4.4	9.6	16.7	4.1	1.8	-3.0	-3.0	-3.1
Bone: maximum diameter	2.3	4.2	6.7	2.6	0.6	-2.2	-2.2	-2.1
Bone: maximum force	1.5	2.6	9.3	-0.2	3.1	0.6	-1.7	0.7
Bone: maximum moment	1.4	2.3	8.3	0.0	2.9	0.4	-1.6	0.7
Mean time between licks in bursts	2.3	3.3	6.8	2.6	-0.4	-2.2	-1.0	-1.9
Mean num. licks in bursts	3.9	4.7	8.3	-2.1	-0.2	2.0	2.6	2.9
Cd content in liver	1.0	1.1	2.2	-1.1	0.6	1.2	0.7	1.5
Co content in liver	0.9	1.1	2.4	-1.2	1.6	0.9	-0.2	0.8
Cu content in liver	3.7	4.5	7.1	-2.3	-1.8	1.8	2.7	1.8
Fe content in liver	1.0	1.2	1.9	-1.1	0.8	1.4	0.8	1.3
K content in liver	0.4	0.4	0.8	0.1	-0.2	-0.7	-0.7	-0.9
Mg content in liver	2.7	2.8	4.8	1.5	-1.6	-1.8	-1.0	-2.2
Mn content in liver	5.5	6.2	9.4	3.0	-1.1	-3.0	-1.5	-3.1
Na content in liver	0.2	0.2	0.4	-0.4	0.3	-0.4	-0.6	-0.2
Rb content in liver	0.3	0.3	1.1	-0.3	-1.1	0.3	0.6	-0.0
Se content in liver	3.9	4.8	7.6	2.6	-1.1	-2.8	-1.3	-2.6
Sr content in liver	1.6	1.5	2.1	1.2	0.7	-1.2	-1.4	-1.3
Zn content in liver	0.6	0.6	1.3	0.5	0.1	-0.9	-0.8	-1.1
Bone: minimum diameter	3.1	5.8	9.1	3.0	0.7	-3.0	-2.2	-2.4
Time in familiar zone, hab. session 1	3.7	3.5	6.0	-2.2	-1.6	0.9	2.5	1.8
Time in novel zone, hab. session 1	2.2	2.1	3.7	1.9	1.1	-0.2	-1.9	-1.4
Total zone transitions, hab. session 1	0.3	0.5	0.9	-0.4	-1.0	-0.3	1.0	0.4
Total locomotion distance, hab. session 1	0.3	0.4	0.9	-0.5	-0.9	-0.3	0.7	0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.7	-0.5	-0.5	0.5	0.2
Time in familiar zone, hab. session 2	0.4	0.4	1.0	-0.8	-0.2	-0.2	1.0	0.5
Time in novel zone, hab. session 2	0.6	0.6	2.4	0.2	0.3	1.5	-0.3	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.6	0.0	-0.0	0.3	0.4
Total locomotion distance, hab. session 2	0.5	0.7	1.6	-0.8	-1.3	0.1	1.0	0.4
Locomotion velocity, hab. session 2	0.5	0.6	1.8	-0.7	-1.3	-0.2	0.9	0.2
Novel to familiar place preference ratio	0.3	0.3	1.1	-0.6	-0.0	1.0	-0.2	0.4
Novelty place preference	0.3	0.3	1.0	-0.3	0.2	1.0	-0.4	0.3
Time in novel zone, NPP test	0.3	0.3	1.0	-0.2	0.3	1.0	-0.5	0.2
Total zone transitions, NPP test	0.7	1.0	2.4	-0.5	-1.5	0.3	1.4	0.7
Total locomotion distance, NPP test	1.0	1.4	2.2	-1.1	-1.5	0.8	1.4	1.0
Locomotion velocity, NPP test	1.4	1.9	3.7	-1.3	-1.9	0.8	1.7	1.1
Intraocular pressure	1.7	2.4	5.2	-0.6	-1.6	0.7	2.3	1.9
Delta distance traveled before/after self-admin	0.3	0.4	1.3	0.1	1.1	0.6	0.1	-0.4
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	0.5	0.7	0.2	-0.2	-0.9
Parametrial fat weight	0.7	1.3	4.3	-0.3	2.1	1.1	-0.2	0.9
Pavlov. Cond. lever latency	3.1	4.0	9.0	-2.3	1.1	3.0	0.9	1.9
Pavlov. Cond. magazine entry latency	2.0	2.6	5.2	2.1	-1.3	-2.3	-0.1	-1.3
Pavlov. Cond. change in total contacts	3.0	3.2	8.5	1.9	0.5	-2.9	-1.1	-1.4
Pavlov. Cond. index score	3.8	4.8	11.6	2.5	-1.3	-3.4	-0.6	-1.9
Pavlov. Cond. latency score	3.8	4.8	11.2	2.6	-1.0	-3.4	-1.0	-2.0
Pavlov. Cond. lever contacts	3.9	4.5	11.6	2.4	-0.6	-3.4	-1.1	-2.0
Pavlov. Cond. magazine entry number	2.0	2.5	6.2	-1.6	1.6	2.5	-0.5	1.0
Pavlov. Cond. intertrial magazine entries	2.9	3.6	6.8	-2.1	-0.7	2.6	1.6	1.9
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.6	11.4	2.4	-1.5	-3.4	-0.4	-1.8
Pavlov. Cond. response bias	3.2	3.8	9.6	2.2	-1.5	-3.1	0.0	-1.6
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.5	0.5	-0.3	-0.7	-0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	0.8	0.7	0.9	-0.7	-0.8	-0.6
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	-0.6	0.6	0.5	0.2	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	0.1	-0.2	0.2	0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.1	0.4	-0.3	0.1	0.1
Pavlov. Cond. lever contacts	0.9	1.2	1.7	-1.1	-0.3	1.2	1.2	1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.1	-0.7	-0.1	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.2	1.4	-1.5	-1.2	-0.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	0.2	-0.2	0.3	0.2
Pavlov. Cond. response bias	0.3	0.5	0.7	-0.5	-0.3	0.7	0.9	0.8
Time in closed arm before self-admin	0.0	0.0	0.2	-0.1	-0.2	-0.4	0.1	0.1
Time in closed arm after self-admin	0.4	0.4	0.8	-0.6	0.9	0.6	-0.6	0.0
Time in open arm before self-admin	0.2	0.2	0.7	0.8	-0.5	0.5	-0.2	0.1
Time in open arm after self-admin	0.2	0.2	0.9	0.5	-0.9	0.1	0.1	-0.1
Bone: periosteal estimation	2.7	5.6	7.7	2.7	2.2	-2.1	-2.8	-1.9
Bone: periosteal perimeter	2.4	4.1	5.5	2.3	1.2	-2.3	-2.2	-1.9
Bone: post-yield work	0.7	0.9	3.0	1.7	-0.4	-0.8	-0.3	-0.8
Progressive ratio test 1 active lever presses	0.4	0.4	1.5	-0.2	-0.1	-0.4	-1.2	-0.5
Progressive ratio test 1 breakpoint	0.5	0.6	2.0	-0.2	-0.0	-0.6	-1.4	-0.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	1.0	-1.0	0.1	0.2	-0.7	0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.8	-0.7	-0.9	0.3	-0.1	0.3
Progressive ratio test 2 breakpoint	0.5	0.6	1.5	-0.9	-1.2	0.3	0.4	0.7
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.6	0.3	0.5	0.2	-1.3	0.1
Incentive Sensitization - Responses	0.5	0.5	1.0	-0.5	-1.0	0.3	1.0	0.5
Incentive Sensitization - Breakpoint	0.7	0.7	1.4	-0.5	-1.2	0.4	1.2	0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.2	-0.6	-0.3	-0.7	-0.6
Progressive ratio	1.6	1.8	6.7	-0.2	2.6	1.1	-1.0	0.4
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.1	0.0	0.1	-0.2	0.6
Seeking ratio, punishment vs. effort	1.2	1.5	5.7	0.1	-2.4	-1.1	0.7	-0.3
Retroperitoneal fat weight	0.1	0.4	1.6	-0.1	1.3	0.3	0.0	0.4
Reaction time number correct	0.6	0.9	2.4	-1.5	0.4	0.6	0.6	1.1
Reaction time mean minus median	1.4	1.9	8.1	2.8	-0.7	-0.8	0.3	-0.5
Reaction time mean minus median AUC	1.1	1.5	5.3	2.3	-0.8	-0.9	0.1	-0.7
Reaction time num false alarms	0.3	0.5	0.7	0.6	0.7	-0.8	-0.5	-0.8
Reaction time num false alarms AUC	0.7	1.0	1.4	0.8	1.0	-1.0	-1.1	-1.2
Reaction time trials correct on left	0.6	0.9	2.4	-1.5	0.4	0.6	0.6	1.1
Reaction time trials on left	0.5	0.8	2.1	-1.4	0.4	0.5	0.6	1.0
Reaction time mean	1.5	2.1	6.8	2.6	-1.2	-1.0	-0.0	-1.1
Reaction time mean AUC	1.5	2.0	6.8	2.6	-1.2	-1.0	0.1	-1.0
Median of all reaction times	1.1	1.5	4.1	2.0	-1.1	-1.0	-0.2	-1.1
Reaction time omissions	1.6	2.1	5.5	2.3	-0.8	-1.7	-0.4	-1.3
Reaction time false alarm rate	1.5	2.1	3.5	1.6	0.6	-1.3	-1.5	-1.9
Reaction time premature initiation rate	0.6	0.9	2.2	0.0	1.5	-0.6	-1.2	-0.5
Reaction time premature initiations	0.7	1.0	3.1	-0.7	1.8	-0.4	-1.0	-0.0
Std. dev. reaction times	1.7	2.4	9.3	3.1	-0.6	-1.1	-0.2	-1.1
Reaction time trials completed	0.5	0.8	2.1	-1.4	0.4	0.5	0.6	1.0
Reaction time trials AUC	0.6	0.8	2.2	-1.5	0.4	0.6	0.6	1.1
Run reversals in cocaine runway, females	0.8	0.7	1.7	-1.3	0.1	0.9	0.6	0.9
Run reversals in cocaine runway, males	1.2	1.2	4.1	2.0	0.4	-0.6	-1.1	-0.2
Latency to leave start box in cocaine runway	0.8	0.8	2.4	0.2	0.4	-0.9	-1.6	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	1.6	0.3	-0.4	-1.2	-1.3	-0.5
Latency to leave start box in cocaine runway, M	0.4	0.4	1.6	-0.4	1.3	0.4	-0.2	0.1
Std. dev. time between licks in bursts	4.2	5.0	7.5	2.7	0.1	-2.2	-2.3	-2.7
Total sessions with >9 infusions	0.8	0.8	2.1	0.1	0.4	-1.0	-1.4	-0.9
Short access day 1 total inactive lever presses	1.9	2.2	3.5	1.8	0.2	-1.9	-1.2	-1.6
Short access day 10 total inactive lever presses	0.2	0.2	0.7	0.8	-0.1	-0.3	-0.3	-0.6
Short access day 1 total infusions	0.9	1.0	2.2	0.2	-0.3	-1.5	-0.8	-1.4
Short access day 10 total infusions	0.5	0.5	1.7	-0.0	0.4	-0.8	-1.3	-0.4
Short access total infusions	1.2	1.3	3.4	0.1	0.4	-1.3	-1.8	-1.0
Short access day 1 locomotion	1.1	1.1	3.8	0.0	-1.9	-1.0	-0.0	-0.9
Short access day 10 total locomotion	3.0	3.3	5.5	1.7	0.1	-2.1	-1.8	-2.3
Short access total locomotion	1.5	1.6	2.9	0.7	-0.3	-1.4	-1.7	-1.6
One hour access (0.3 mA shock)	0.2	0.2	0.6	-0.1	-0.8	-0.1	-0.6	0.1
Compulsive drug intake	1.1	1.1	3.3	0.2	-1.8	-0.6	-0.6	-1.3
One hour access (shock baseline)	0.2	0.3	0.6	0.3	0.6	0.4	-0.1	0.8
Social response proportion	1.3	1.4	2.2	1.1	0.4	-1.5	-1.1	-1.5
Social responses	0.8	1.1	2.0	0.5	0.8	-1.4	-0.9	-1.3
Social time	3.4	4.4	7.6	2.8	0.2	-2.5	-1.6	-2.4
Soleus weight	3.8	11.1	16.6	4.1	0.4	-3.5	-3.5	-3.8
Bone: stiffness	0.4	0.6	2.0	-0.6	1.4	0.2	-0.4	0.8
Tibialis anterior weight	0.3	1.0	2.5	-1.6	0.1	1.1	0.6	1.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	-0.3	-0.3	0.0	0.6
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.4	1.2	-1.1	-0.4	0.5	0.1
Time to tail flick, test, before self-admin	0.5	0.5	1.0	-0.6	0.3	1.0	0.0	1.0
Time to tail flick, test, after self-admin	1.3	1.3	2.8	0.6	-1.5	0.9	1.7	0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.4	-0.1	-1.1	0.6	1.2	0.3
Delta time to tail flick, test, before/after SA	1.3	1.2	3.3	-0.2	-1.4	0.4	1.8	0.5
Tibia length	2.6	7.3	9.8	3.1	2.5	-2.6	-2.8	-2.3
Ambulatory time before self-admin	0.1	0.1	0.5	0.3	-0.0	0.7	-0.0	-0.2
Ambulatory time after self-admin	0.2	0.2	0.7	0.8	0.1	0.3	0.5	-0.5
Bone: tissue strength	1.6	1.6	4.6	-0.3	2.1	1.1	-1.4	0.4
Total heroin consumption	0.1	0.1	0.4	0.0	-0.2	0.7	-0.3	0.3
Bone: trabecular number	2.4	3.8	5.6	-1.8	-1.8	2.4	1.7	2.0
Bone: trabecular spacing	3.3	4.3	7.1	1.6	2.7	-1.8	-2.3	-1.8
Bone: trabecular thickness	1.7	2.1	2.7	-1.2	-1.4	1.2	1.6	1.6
Bone: trabecular tissue density	0.8	1.2	3.4	0.2	1.8	-0.6	-1.3	-0.6
Water consumed over 24 hours	0.2	0.3	0.5	0.6	0.1	-0.4	-0.7	-0.7
Number of responses in last shaping day	2.6	2.7	5.3	0.8	0.7	-1.9	-2.3	-1.9